+
|
abolished protein phosphorylation
|
|
cdc10-S720A,S732A(aa)
|
|
ark1-K147R(aa)
affecting
bir1
|
|
bpb1-2A(S131A,S133A aa)
affecting
bpb1
modified residue
S131,S133
|
|
bpb1-P132G,P134G(aa)
affecting
bpb1
modified residue
S131,S133
|
|
bpb1-R128E,R130E(aa)
affecting
bpb1
modified residue
S131,S133
|
|
cdc17-K42(E298K aa)
affecting
cdc2
modified residue
T14
|
|
cdc4-S2A,S6A(aa)
affecting
cdc4
|
|
cdr1-K41A(aa)
affecting
wee1
|
|
dis1-6A(T279A,S293A,S300A,S551A,S556A,S590A aa)
affecting
dis1
modified residue
S551
|
|
dis1Δ
affecting
dis1
modified residue
S551
|
|
gad8-K259R(aa)
affecting
tor1
modified residue
T1972
|
|
gad8Δ
affecting
tor1
modified residue
T1972
|
|
kin1-TA(T299A aa)
affecting
kin1
|
|
ksg1-208(G159E aa)
affecting
gad8
modified residue
T387
|
|
mal3-Q89R,S147A,T149A,S151A(aa)
affecting
mal3
|
|
mph1-kd(D459A aa)
affecting
spc7
|
|
pds5Δ
affecting
rad21
|
|
pef1Δ
affecting
rad21
modified residue
T262
|
|
psl1Δ
affecting
rad21
|
|
rad21-T262A(aa)
affecting
rad21
modified residue
T262
|
|
sin1-(1-290)(291-665 Δaa)
affecting
gad8
|
|
sin1-(247-380)(1-246,381-665 Δaa)[Overexpression]
affecting
gad8
|
|
sin1-A319D(aa)
affecting
gad8
|
|
sin1-Δ291-390(aa)
affecting
gad8
|
|
sin1-L310H(aa)
affecting
gad8
|
|
sin1-L348S(aa)
affecting
gad8
|
|
sin1-L364S(aa)
affecting
gad8
|
|
sin1-polyNQ(E352Q,D353N,D354N,E356Q,D358N,E359Q,D360N aa)
affecting
gad8
|
|
sin1-Y327D(aa)
affecting
gad8
|
|
spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
affecting
spc7
|
|
ssp1-KD(K164A aa)
affecting
cdr2
modified residue
T166
|
|
ssp1Δ
affecting
cdr2
modified residue
T166
|
|
ssp1Δ
affecting
kin1
|
|
ste11-T173D,S218D(aa)
affecting activity of
pat1
affecting substrate
ste11
|
|
tor2-L2048S(aa)
affecting
psk1
,
rps602
|
|
wat1-17(C233Y aa)
affecting
psk1
,
rps602
|
|
wat1Δ
affecting
psk1
,
rps602
|
|
wis1-DD(S469D,T473D aa)[Overexpression]
affecting
sty1
modified residue
Y173,T171
|
|
wis1ΔN300(1-300 Δaa)[Overexpression]
affecting
sty1
modified residue
Y173,T171
|
|
wpl1Δ
affecting
rad21
|
|
xlf1.AA(T180A,S192A aa)
affecting activity of
cdc2
affecting substrate
xlf1
|
+
|
abolished protein phosphorylation during cellular response to hydroxyurea
|
|
cdc21-M68(unknown)
affecting
mcm4
|
|
cdc45-3A(S275A,S322A,S397A aa)
affecting
cdc45
|
|
cds1-FHA(S78A,H81A aa)
affecting
cds1
|
|
cds1-H81A(aa)
affecting
cds1
|
|
cds1-N107A(aa)
affecting
cds1
|
|
cds1-R64A(aa)
affecting
cds1
|
|
cds1-S78A(aa)
affecting
cds1
|
|
cds1-T11A(aa)
affecting
cds1
|
|
cds1Δ
affecting
hsk1
|
|
hsk1-1312(S314I aa)
affecting
hsk1
|
|
hsk1-89(L339P,E403K,L416P aa)
affecting
cds1
,
mrc1
|
|
mrc1-6A(S599A,S604A,S614A,T634A,S637A,T645A aa)
affecting
mrc1
|
|
mrc1-TQ(T645A,T653A aa)
affecting
cds1
|
|
mrc1Δ
affecting
cds1
|
|
rad26Δ
affecting
cds1
modified residue
T11
|
|
rad26Δ
affecting
mrc1
modified residue
T645
|
|
rad3-D2249E(aa)
affecting
mrc1
modified residue
T645
|
|
rad3-D2249E(aa)
affecting
rad26
|
|
rad3-D2249E(aa)
affecting
rad9
modified residue
T412
|
|
rad3Δ
affecting
cds1
,
chk1
,
rad26
|
|
rad3Δ
affecting
cds1
modified residue
T11
|
|
rad3Δ
affecting
mrc1
modified residue
T645
|
|
rad9-T412A,S423A(aa)
affecting
rad9
|
+
|
abolished protein phosphorylation during vegetative growth
|
|
dma1-6A(S4A,T18A,S20A,S166A,S251A,S266A aa)
,
pir1-S12A(S215A,S233A,S237A,S248A,S265A,S285A,S299A,S303A,S325A,S334A,S434A,S503A aa)
,
plo1-as8(C55V,L117G,M170F aa)
|
|
act1-R183A,D184A(aa)
affecting
sty1
|
|
arf6Δ
affecting
wee1
|
|
bub1-KD(K762R,D900N aa)
affecting activity of
bub1
affecting substrate
hta1
and
hta2
|
|
bun107Δ
affecting
ubp9
|
|
bun62Δ
affecting
ubp9
|
|
byr4-7A(S248A,S326A,T412A,T429A,S499A,T502A,S533A aa)
affecting
byr4
|
|
cdc13-R9(unknown)
affecting
srw1
|
|
cdc13Δ
affecting
orc2
|
|
cdc2-33(A177T aa)
affecting
srw1
|
|
cdc2-as(F84G aa)
affecting
mde4
|
|
cdc2-T14A(aa)
affecting
cdc2
modified residue
T14
|
|
cdc2-Y15F(aa)
affecting
cdc2
modified residue
Y15
|
|
cdc25-13A(S3A,S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,S332A,S334A,T351A,T379A aa)
affecting
cdc25
|
|
cdr2-1-330(ΔC-KA1)(331-775 Δaa)
affecting
wee1
|
|
cdr2-S755A(aa)
affecting
cdr2
modified residue
S755
|
|
cdr2Δ
affecting
wee1
|
|
csk1Δ
affecting
mcs6
|
|
fin1-3A(S377A,S526A,S698A aa)
affecting
cut12
modified residue
T75,T78
|
|
fin1-as3(M82G,G168A aa)
affecting
cut12
modified residue
T75,T78
|
|
fkh2-S2A(S322A,S375A aa)
affecting
fkh2
modified residue
S375
modified residue
S322
|
|
fkh2-S2E(S322E,S375E aa)
affecting
fkh2
modified residue
S375
modified residue
S322
|
|
fkh2-S321A(aa)
affecting activity of
gad8
affecting substrate
fkh2
|
|
gad8-K259D(aa)
affecting
fkh2
|
|
gad8-K259R(aa)
affecting
tor2
modified residue
S1975
|
|
gcn2-K585R(aa)
affecting
tif211
|
|
gcn2-T818A,T823A(aa)
affecting
tif211
|
|
git3Δ
affecting
fkh2
|
|
git3Δ
affecting
gad8
modified residue
S546
|
|
git5Δ
affecting
fkh2
|
|
git5Δ
affecting
gad8
modified residue
S546
|
|
gpa2Δ
affecting
fkh2
|
|
gpa2Δ
affecting
gad8
modified residue
S546
|
|
gsk3-K61A(aa)
affecting
gsk3
modified residue
Y192
|
|
gsk3-Y192E(aa)
affecting
gsk3
modified residue
Y192
|
|
gsk3-Y192F(aa)
affecting
gsk3
modified residue
Y192
|
|
hcn1-S48A(aa)
affecting
hcn1
|
|
isp7Δ
affecting
rps602
|
|
mkh1Δ
affecting
pmk1
|
|
nak1-5A(S479A,S491A,S501A,S533A,S561A aa)
affecting
nak1
modified residue
S561A
modified residue
S533A
modified residue
S501A
modified residue
S491A
modified residue
S479A
|
|
orp2-T4A(T8A,T21A,T26A,T29A aa)
affecting
orc2
|
|
pek1-A(T238A aa)
affecting
rnc1
modified residue
T50
|
|
pek1Δ
affecting
pmk1
|
|
pka1Δ
affecting
fkh2
|
|
pka1Δ
affecting
gad8
modified residue
S546
|
|
plo1-24c(unknown)
affecting
pcp1
|
|
pmk1-K52R(aa)
affecting
rnc1
modified residue
T50
|
|
pmk1Δ
affecting
nrd1
|
|
pmk1Δ
affecting
rnc1
modified residue
T50
|
|
pom1-KD(K728R aa)
affecting
cdr2
modified residue
T166
|
|
psk1-K120A(aa)
affecting activity of
psk1
affecting substrate
rps602
modified residue
S236
modified residue
S235
|
|
psk1-S248A(aa)
affecting
rps601
and
rps602
modified residue
S236
modified residue
S235
|
|
psk1-TTAA(T392A,T415A aa)
affecting
rps601
and
rps602
modified residue
S236
modified residue
S235
|
|
ran1-K47R(aa)
affecting
ste11
|
|
rgp1Δ
affecting
fkh2
|
|
rgp1Δ
affecting
gad8
modified residue
S546
|
|
rnc1-T50A(aa)
affecting
rnc1
|
|
rpb1-CTD-S2A(aa)
affecting
rpb1
|
|
rpb1-CTD-S5A(aa)
affecting
rpb1
|
|
rps601-S235A,S236A(aa)
affecting
rps601
|
|
rps602-S235A,S236A(aa)
affecting
rps602
|
|
rum1-T58A,T62A(aa)
affecting
rum1
modified residue
A58 A62
|
|
sck2Δ
affecting
rps601
and
rps602
modified residue
S236
modified residue
S235
|
|
sid2-as4(M285A,T348A aa)
affecting
cut12
modified residue
T75,T78
|
|
sin1Δ
affecting
gad8
|
|
sld3-9A(S140A,T201A,T228A,S499A,T636A,T650A,S673A,T690A,S698A aa)
affecting
sld3
|
|
ste20Δ
affecting
gad8
|
|
sty1Δ
affecting
srk1
|
|
syt22Δ
affecting
wee1
|
|
tor1Δ
affecting
fkh2
,
gad8
|
|
tor1Δ
affecting
gad8
modified residue
S546
|
|
tor1ΔC(1987-2335 Δnt)
affecting
gad8
|
|
tor1ΔFATC(2303-2335 Δnt)
affecting
gad8
|
|
wat1-17(C233Y aa)
affecting
gad8
|
|
wat1Δ
affecting
gad8
|
|
wis1-K349R(aa)
affecting
sty1
|