Last updated: 2025-03-13 429297 annotations 4738 curated publications
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Ontology term: decreased chromatin binding (FYPO:0002577)
Definition Parents
A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene, and may normally bind DNA, protein, or both in chromatin.
External links: BioPortal
Single locus phenotype annotations for FYPO:0002577 and its descendants
Cell
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+ decreased chromatin binding
seb1-F445A(aa) ,   seb1-S22D,K25E,K124E(aa) ,   seb1-Y64K(aa)
bub1-KD(K762R,D900N aa) affecting sgo1
cdc10-C4(R707*) affecting yox1
cdc18+[Knockdown] affecting rad3
cdc22-M45(unknown) affecting rad17
cdk9-T120G(aa) affecting spt5
dcr1Δ affecting telomere , mating_type_region affecting swi6
dis2Δ affecting spt5
fkh2Δ affecting mei4
lem2Δ affecting clr1
mis18-I31A(aa) affecting mis18
mis18-Y114A(aa) affecting mis18
pfs2-11(unknown) affecting spt5
rad17-K118E(aa) affecting rad17
rad17Δ affecting rad9
seb1-CIDmut(Y64A,D67A,R71A aa) affecting seb1
seb1-RRMmut(R442A,H443A,F445A,K447A aa) affecting seb1
tti2+[Knockdown] affecting spt7 , tra1 , tra2
+ decreased chromatin binding at centromere central core
chp2-H5A+CSD2A(K271A,R272A,R273A,R274A,R276A,K321A,K322A aa)
hrp1Δ affecting cnp1
+ decreased chromatin binding at centromere outer repeat
chp2-H5A+CSD3A(K271A,R272A,R273A,R274A,R276A,Q320A,K321A,K322A aa) ,   tas3-I471E(aa) ,   tas3-L479E(aa) ,   tas3-L502E(aa) ,   tas3ΔTAM(422-549 Δaa)
mit1-K587A(aa) affecting chp2
mit1ΔPHD(unknown) affecting chp2
+ decreased chromatin binding at cohesin associated regions
mis4-367(G1487D aa) affecting rad21
pph3Δ affecting mis4 , rad21
+ decreased chromatin binding at heat-shock-inducible genes during cellular response to heat shock
cut14-208(S861P aa) affecting cut14
+ decreased chromatin binding at histone promoter
ams2-MZF(C375A,C378A aa) affecting ams2
teb1-1(R184C aa) affecting ams2 , teb1
+ decreased chromatin binding at mating-type region replication fork barrier
lsd1-E918(E918*) affecting lsd1
swi1Δ affecting lsd1
+ decreased chromatin binding at mitotically up-regulated genes
sep1Δ affecting cut14
+ decreased chromatin binding at promoter element during glucose starvation
php5Δ affecting STREP_motif affecting atf1
php5Δ affecting STREP_motif affecting rst2
rst2Δ affecting CRE , STREP_motif affecting atf1
rst2Δ affecting CRE affecting php2
+ decreased chromatin binding at rDNA replication fork barrier
lsd1-E918(E918*) affecting swi1
+ decreased chromatin binding at replication origin
nda4-108(R50C aa) affecting cdc45
+ decreased chromatin binding during cellular response to methyl methanesulfonate
rad17-K118E(aa) affecting kpa1
+ decreased chromatin binding during cellular response to nitrogen starvation
rpb1-CTD-S2A(aa) affecting rpb3
+ decreased nucleosome binding
ani1-F301C,W314C,Y337K(aa) ,   hrp3-Δchromo(192-340 Δaa) ,   hrp3-Δcoupling_region(927-935 Δaa) ,   hrp3-ΔSANT(994-1049 Δaa) ,   hrp3-ΔSLIDE(1103-1205 Δaa) ,   pdp1-F94A(aa)[Endogenous] ,   pdp1-W66A(aa)[Endogenous]
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