id: gomodel:689e7a5d00000253
title: mitochondrial tRNA modification (GO:0070900 ) (valine)
taxon: NCBITaxon:4896
status: production
date_modified: '2025-12-01'
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    term: GO:0103016
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:1990799
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000002191
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    term: GO:1990799
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000051
      with_objects:
      - SGD:S000002191
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    provenances:
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      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:689e7a5d00000253/689e7a5d00000561
- id: gomodel:689e7a5d00000253/689e7a5d00000254
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:20106903
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000236067
      - UniProtKB:P07118
      - PomBase:SPAC4A8.08c
      - RGD:3950
      - PomBase:SPBC1709.02c
      - UniProtKB:Q5ST30
      - SGD:S000003326
      - UniProtKB:P26640
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    provenances:
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      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC4A8.08c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004832
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0004832,GO:0005739
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000236067
      - SGD:S000003326
      - UniProtKB:P07118
      provenances:
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        date: '2025-08-18'
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    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    term: GO:0006438
  has_input:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57762
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:20106903
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000236067
      - UniProtKB:P07118
      - PomBase:SPAC4A8.08c
      - RGD:3950
      - PomBase:SPBC1709.02c
      - UniProtKB:Q5ST30
      - SGD:S000003326
      - UniProtKB:P26640
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:20106903
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000236067
      - UniProtKB:P07118
      - PomBase:SPAC4A8.08c
      - RGD:3950
      - PomBase:SPBC1709.02c
      - UniProtKB:Q5ST30
      - SGD:S000003326
      - UniProtKB:P26640
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57762
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:20106903
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000236067
      - UniProtKB:P07118
      - PomBase:SPAC4A8.08c
      - RGD:3950
      - PomBase:SPBC1709.02c
      - UniProtKB:Q5ST30
      - SGD:S000003326
      - UniProtKB:P26640
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:689e7a5d00000253/689e7a5d00000282
  - type: CausalAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:20106903
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000236067
      - UniProtKB:P07118
      - PomBase:SPAC4A8.08c
      - RGD:3950
      - PomBase:SPBC1709.02c
      - UniProtKB:Q5ST30
      - SGD:S000003326
      - UniProtKB:P26640
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:689e7a5d00000253/689e7a5d00000282
  - type: CausalAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:20106903
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000236067
      - UniProtKB:P07118
      - PomBase:SPAC4A8.08c
      - RGD:3950
      - PomBase:SPBC1709.02c
      - UniProtKB:Q5ST30
      - SGD:S000003326
      - UniProtKB:P26640
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:689e7a5d00000253/689e7a5d00000267
- id: gomodel:689e7a5d00000253/689e7a5d00000447
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000501
      reference: GO_REF:0000116
      with_objects:
      - RHEA:36407
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPCC895.03c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0061710
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0061710
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000304
      reference: PMID:25038083
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    term: GO:0072670
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000501
      reference: GO_REF:0000116
      with_objects:
      - RHEA:36407
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000501
      reference: GO_REF:0000116
      with_objects:
      - RHEA:36407
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-08-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:689e7a5d00000253/689e7a5d00000433
  - type: CausalAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-08-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:689e7a5d00000253/689e7a5d00000433
objects:
- id: GO:0004832
  label: valine-tRNA ligase activity
  type: gocam:Object
- id: PomBase:SPAC4A8.08c
  label: vrs2 Spom
  type: gocam:Object
- id: GO:0006438
  label: valyl-tRNA aminoacylation
  type: gocam:Object
- id: GO:0005759
  label: mitochondrial matrix
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:57762
  label: L-valine zwitterion
  type: gocam:Object
- id: GO:0030674
  label: protein-macromolecule adaptor activity
  type: gocam:Object
- id: PomBase:SPBC9B6.04c
  label: tuf1 Spom
  type: gocam:Object
- id: GO:0070125
  label: mitochondrial translational elongation
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:2651
  label: alpha-aminoacyl-tRNA
  type: gocam:Object
- id: GO:0005763
  label: mitochondrial small ribosomal subunit
  type: gocam:Object
- id: GO:0033451
  label: GUA codon-amino acid adaptor activity
  type: gocam:Object
- id: PomBase:SPMITTRNAVAL.01
  label: SPMITTRNAVAL.01 Spom
  type: gocam:Object
- id: ECO:0000255
  label: match to sequence model evidence used in manual assertion
  type: gocam:Object
- id: GO:0052929
  label: ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity
  type: gocam:Object
- id: PomBase:SPCC645.10
  label: cca2 Spom
  type: gocam:Object
- id: GO:1990180
  label: mitochondrial tRNA 3'-end processing
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: GO:0061711
  label: tRNA N(6)-L-threonylcarbamoyladenine synthase activity
  type: gocam:Object
- id: PomBase:SPCC1259.10
  label: pgp1 Spom
  type: gocam:Object
- id: GO:0072670
  label: mitochondrial tRNA threonylcarbamoyladenosine modification
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: GO:0061710
  label: L-threonylcarbamoyladenylate synthase activity
  type: gocam:Object
- id: PomBase:SPCC895.03c
  label: sua5 Spom
  type: gocam:Object
- id: ECO:0000501
  label: evidence used in automatic assertion
  type: gocam:Object
- id: ECO:0000304
  label: author statement supported by traceable reference used in manual assertion
  type: gocam:Object
- id: GO:0003924
  label: GTPase activity
  type: gocam:Object
- id: PomBase:SPAC222.05c
  label: mss1 Spom
  type: gocam:Object
- id: GO:0070899
  label: mitochondrial tRNA wobble uridine modification
  type: gocam:Object
- id: GO:0160236
  label: tRNA 5-taurinomethyluridine synthase activity
  type: gocam:Object
- id: PomBase:SPBC30B4.06c
  label: ips1 Spom
  type: gocam:Object
- id: GO:0031071
  label: cysteine desulfurase activity
  type: gocam:Object
- id: PomBase:SPBC21D10.11c
  label: nfs1 Spom
  type: gocam:Object
- id: GO:1990799
  label: mitochondrial tRNA wobble position uridine thiolation
  type: gocam:Object
- id: GO:0103016
  label: tRNA-uridine 2-sulfurtransferase activity
  type: gocam:Object
- id: PomBase:SPAC23H4.04
  label: slm3 Spom
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  - https://orcid.org/0009-0003-9059-1333
  date: '2025-12-01'
  provided_by:
  - http://www.pombase.org
