id: gomodel:678073a900003175
title: homoserine biosynthetic process (GO:0009090), threonine biosynthetic process
  (GO:0009088), glycine biosynthetic process (GO:0006545)
taxon: NCBITaxon:4896
status: production
date_modified: '2025-08-31'
activities:
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    term: PomBase:SPAC23H3.09c
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    term: GO:0005829
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  molecular_function:
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    term: GO:0071266
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    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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    evidence:
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    term: CHEBI:16288
objects:
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  label: cytosol
  type: gocam:Object
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  label: curator inference used in manual assertion
  type: gocam:Object
- id: CHEBI:29991
  label: L-aspartate(1-)
  type: gocam:Object
- id: GO:0015195
  label: L-threonine transmembrane transporter activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: GO:0170036
  label: import into the mitochondrion
  type: gocam:Object
- id: GO:0031966
  label: mitochondrial membrane
  type: gocam:Object
- id: CHEBI:16857
  label: L-threonine
  type: gocam:Object
- id: GO:0005759
  label: mitochondrial matrix
  type: gocam:Object
- id: GO:0008732
  label: L-allo-threonine aldolase activity
  type: gocam:Object
- id: PomBase:SPAC23H3.09c
  label: gly1 Spom
  type: gocam:Object
- id: GO:0006545
  label: glycine biosynthetic process
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:57305
  label: glycine zwitterion
  type: gocam:Object
- id: GO:0015187
  label: glycine transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC4G9.20c
  label: ymc1 Spom
  type: gocam:Object
- id: GO:1904983
  label: glycine import into mitochondrion
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC823.10c
  label: hem25 Spom
  type: gocam:Object
- id: GO:0004820
  label: glycine-tRNA ligase activity
  type: gocam:Object
- id: PomBase:SPAC3F10.03
  label: grs1 Spom
  type: gocam:Object
- id: GO:0070150
  label: mitochondrial glycyl-tRNA aminoacylation
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:29156
  label: Gly-tRNA(Gly)
  type: gocam:Object
- id: PomBase:SPMITTRNAGLY.01
  label: SPMITTRNAGLY.01 Spom
  type: gocam:Object
- id: GO:0004072
  label: aspartate kinase activity
  type: gocam:Object
- id: PomBase:SPBC19F5.04
  label: hom3 Spom
  type: gocam:Object
- id: GO:0009090
  label: L-homoserine biosynthetic process
  type: gocam:Object
- id: CHEBI:57535
  label: 4-phosphonato-L-aspartic acid(2-)
  type: gocam:Object
- id: GO:0004073
  label: aspartate-semialdehyde dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPCC1827.06c
  label: hom2 Spom
  type: gocam:Object
- id: CHEBI:13086
  label: L-aspartate 4-semialdehyde
  type: gocam:Object
- id: GO:0004412
  label: homoserine dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPBC776.03
  label: hom6 Spom
  type: gocam:Object
- id: CHEBI:15699
  label: L-homoserine
  type: gocam:Object
- id: GO:0004414
  label: homoserine O-acetyltransferase activity
  type: gocam:Object
- id: PomBase:SPBC56F2.11
  label: met6 Spom
  type: gocam:Object
- id: GO:0071266
  label: '''de novo'' L-methionine biosynthetic process'
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:15351
  label: acetyl-CoA
  type: gocam:Object
- id: CHEBI:16288
  label: O-acetyl-L-homoserine
  type: gocam:Object
- id: GO:0004413
  label: homoserine kinase activity
  type: gocam:Object
- id: PomBase:SPBC4C3.03
  label: thr1 Spom
  type: gocam:Object
- id: GO:0009088
  label: L-threonine biosynthetic process
  type: gocam:Object
- id: CHEBI:15961
  label: O-phospho-L-homoserine
  type: gocam:Object
- id: GO:0004795
  label: threonine synthase activity
  type: gocam:Object
- id: PomBase:SPAC9E9.06c
  label: SPAC9E9.06c Spom
  type: gocam:Object
- id: GO:0004829
  label: threonine-tRNA ligase activity
  type: gocam:Object
- id: PomBase:SPAC24C9.09
  label: SPAC24C9.09 Spom
  type: gocam:Object
- id: GO:0006435
  label: threonyl-tRNA aminoacylation
  type: gocam:Object
- id: PomBase:SPMITTRNATHR.01
  label: SPMITTRNATHR.01 Spom
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  - https://orcid.org/0009-0003-9059-1333
  date: '2025-08-31'
  provided_by:
  - http://www.pombase.org
