id: gomodel:671ae02600003478
title: 'cell integrity MAPK cascade (GO:0000196)

  '
taxon: NCBITaxon:4896
status: production
date_modified: '2025-03-17'
comments:
- pathway hole inferred from genetics https://github.com/pombase/curation/issues/3773#issuecomment-2724485082
activities:
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        Ext: part of : positive regulation of cell integrity MAPK cascade


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        Ext: part of : positive regulation of cell integrity MAPK cascade


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        Ext: part of : positive regulation of cell integrity MAPK cascade


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      - http://www.pombase.org
    predicate: RO:0002629
    downstream_activity: gomodel:671ae02600003478/671ae02600003510
objects:
- id: GO:0043539
  label: protein serine/threonine kinase activator activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: GO:0097575
  label: lateral cell cortex
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: GO:0005938
  label: cell cortex
  type: gocam:Object
- id: GO:0004709
  label: MAP kinase kinase kinase activity
  type: gocam:Object
- id: PomBase:SPAC1F3.02c
  label: mkh1 Spom
  type: gocam:Object
- id: GO:0000196
  label: cell integrity MAPK cascade
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0004708
  label: MAP kinase kinase activity
  type: gocam:Object
- id: PomBase:SPBC543.07
  label: pek1 Spom
  type: gocam:Object
- id: GO:0004707
  label: MAP kinase activity
  type: gocam:Object
- id: PomBase:SPBC119.08
  label: pmk1 Spom
  type: gocam:Object
- id: PomBase:SPAC16.01
  label: rho2 Spom
  type: gocam:Object
- id: GO:1903139
  label: positive regulation of cell integrity MAPK cascade
  type: gocam:Object
- id: GO:0005886
  label: plasma membrane
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: GO:0004674
  label: protein serine/threonine kinase activity
  type: gocam:Object
- id: PomBase:SPAC17G8.14c
  label: pck1 Spom
  type: gocam:Object
- id: PomBase:SPBC12D12.04c
  label: pck2 Spom
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC1F7.04
  label: rho1 Spom
  type: gocam:Object
- id: GO:0017017
  label: MAP kinase tyrosine/serine/threonine phosphatase activity
  type: gocam:Object
- id: PomBase:SPBC1685.01
  label: pmp1 Spom
  type: gocam:Object
- id: GO:1903138
  label: negative regulation of cell integrity MAPK cascade
  type: gocam:Object
- id: GO:0005096
  label: GTPase activator activity
  type: gocam:Object
- id: PomBase:SPBC28E12.03
  label: rga4 Spom
  type: gocam:Object
- id: ECO:0000353
  label: physical interaction evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPBC23G7.08c
  label: rga7 Spom
  type: gocam:Object
- id: PomBase:SPAC2F7.03c
  label: pom1 Spom
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2025-03-17'
  provided_by:
  - http://www.pombase.org
