id: gomodel:6690711d00002904
title: L-histidine biosynthetic process (GO:0000105)
taxon: NCBITaxon:4896
status: production
date_modified: '2025-08-27'
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      - SGD:S000005728
      - UniProtKB:O23346
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      - http://www.pombase.org
    term: PomBase:SPBC21H7.07c
  molecular_function:
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    term: GO:0004424
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    type: CellularAnatomicalEntityAssociation
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    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
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    provenances:
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      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
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      with_objects:
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      - CGD:CAL0000187142
      - UniProtKB:Q5AYU4
      - TAIR:locus:1005716545
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      - SGD:S000005728
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      date: '2024-07-25'
      provided_by:
      - http://www.pombase.org
    term: GO:0000105
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    evidence: []
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      provided_by:
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    predicate: RO:0002413
    downstream_activity: gomodel:6690711d00002904/6690711d00002999
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - TAIR:locus:1005716545
      - SGD:S000005728
      - UniProtKB:O23346
      - CGD:CAL0000187142
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      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-07-25'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - UniProtKB:O23346
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      - UniProtKB:Q5AYU4
      provenances:
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    predicate: RO:0002413
    downstream_activity: gomodel:6690711d00002904/6690711d00002999
- id: gomodel:6690711d00002904/6690711d00002928
  enabled_by:
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    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
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      - SGD:S000001282
      - UniProtKB:P10371
      - TAIR:locus:2049470
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    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-07-25'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC3F10.09
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0003949
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    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
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        - https://orcid.org/0000-0001-6330-7526
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    - contributor:
      - https://orcid.org/0000-0001-6330-7526
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      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000478036
      - TAIR:locus:2049470
      - SGD:S000001282
      - UniProtKB:P10371
      - UniProtKB:P9WMM5
      provenances:
      - contributor:
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        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-07-25'
      provided_by:
      - http://www.pombase.org
    term: GO:0000105
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000478036
      - SGD:S000001282
      - UniProtKB:P10371
      - TAIR:locus:2049470
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
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        provided_by:
        - http://www.pombase.org
    provenances:
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      - https://orcid.org/0000-0001-6330-7526
      date: '2024-07-25'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:6690711d00002904/6690711d00002944
- id: gomodel:6690711d00002904/67c10cc400007262
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-21'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:36080
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0005290
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-21'
      provided_by:
      - http://www.pombase.org
    term: GO:0031966
  part_of:
    type: BiologicalProcessAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-21'
      provided_by:
      - http://www.pombase.org
    term: GO:0089709
  has_input:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-21'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57595
  has_output:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-21'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57595
objects:
- id: CHEBI:73183
  label: 1-(5-phospho-beta-D-ribosyl)-ATP(6-)
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: GO:0003879
  label: ATP phosphoribosyltransferase activity
  type: gocam:Object
- id: PomBase:SPAC25G10.05c
  label: his1 Spom
  type: gocam:Object
- id: GO:0000105
  label: L-histidine biosynthetic process
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0004636
  label: phosphoribosyl-ATP diphosphatase activity
  type: gocam:Object
- id: PomBase:SPBC29A3.02c
  label: his7 Spom
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: GO:0004635
  label: phosphoribosyl-AMP cyclohydrolase activity
  type: gocam:Object
- id: GO:0003949
  label: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide
    isomerase activity
  type: gocam:Object
- id: PomBase:SPAC3F10.09
  label: his6 Spom
  type: gocam:Object
- id: GO:0004424
  label: imidazoleglycerol-phosphate dehydratase activity
  type: gocam:Object
- id: PomBase:SPBC21H7.07c
  label: his5 Spom
  type: gocam:Object
- id: GO:0000107
  label: imidazoleglycerol-phosphate synthase activity
  type: gocam:Object
- id: PomBase:SPBC418.01c
  label: his4 Spom
  type: gocam:Object
- id: GO:0004399
  label: histidinol dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPBC1711.13
  label: his2 Spom
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPBC11B10.02c
  label: his3 Spom
  type: gocam:Object
- id: CHEBI:57595
  label: L-histidine zwitterion
  type: gocam:Object
- id: GO:0004400
  label: histidinol-phosphate transaminase activity
  type: gocam:Object
- id: ECO:0000304
  label: author statement supported by traceable reference used in manual assertion
  type: gocam:Object
- id: GO:0004401
  label: histidinol-phosphatase activity
  type: gocam:Object
- id: PomBase:SPCC1672.01
  label: SPCC1672.01 Spom
  type: gocam:Object
- id: GO:0005290
  label: L-histidine transmembrane transporter activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: GO:0089709
  label: L-histidine transmembrane transport
  type: gocam:Object
- id: GO:0031966
  label: mitochondrial membrane
  type: gocam:Object
- id: GO:0005759
  label: mitochondrial matrix
  type: gocam:Object
- id: GO:0004821
  label: histidine-tRNA ligase activity
  type: gocam:Object
- id: PomBase:SPBC2G2.12
  label: hrs1 Spom
  type: gocam:Object
- id: GO:0006427
  label: histidyl-tRNA aminoacylation
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: PomBase:SPMITTRNAHIS.01
  label: SPMITTRNAHIS.01 Spom
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2025-08-27'
  provided_by:
  - http://www.pombase.org
