id: gomodel:682fbcd000005519
title: mitochondrial fission  (GO:0000266), mitochondrial fusion (GO:0008053)
taxon: NCBITaxon:4896
status: production
activities:
- id: gomodel:682fbcd000005519/682fbcd000005520
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000304
      reference: PMID:37590302
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-06'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-06'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC11G11.01
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0043495
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000304
      reference: PMID:37590302
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-06'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-06'
      provided_by:
      - http://www.pombase.org
    term: GO:0032473
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000250
      reference: GO_REF:0000024
      with_objects:
      - UniProtKB:P40515
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-06'
        provided_by:
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    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-06'
      provided_by:
      - http://www.pombase.org
    term: GO:0090149
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000304
      reference: PMID:37590302
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-06'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-06'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:682fbcd000005519/682fbcd000005527
- id: gomodel:682fbcd000005519/682fbcd000005535
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000304
      reference: PMID:19373772
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-06'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-06'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC12C2.08
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:1990606
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000003924
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-06'
        provided_by:
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    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-06'
      provided_by:
      - http://www.pombase.org
    term: GO:0005741
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:19373772
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-06'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000315
      reference: PMID:19373772
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-06'
        provided_by:
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    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-06'
      provided_by:
      - http://www.pombase.org
    term: GO:0090149
- id: gomodel:682fbcd000005519/682fbcd000005873
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN002514495
      - UniProtKB:Q8N2K1
      - UniProtKB:Q16763
      - WB:WBGene00002344
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      - UniProtKB:P68036
      - UniProtKB:P61088
      - WB:WBGene00006713
      - MGI:MGI:2388672
      - MGI:MGI:1917343
      - MGI:MGI:104632
      - UniProtKB:Q9Y385
      - UniProtKB:A1L167
      - UniProtKB:P61077
      - UniProtKB:O00762
      - MGI:MGI:107411
      - UniProtKB:Q9NPD8
      - FB:FBgn0026316
      - UniProtKB:Q969T4
      - UniProtKB:Q96LR5
      - UniProtKB:Q96B02
      - PomBase:SPAC11E3.04c
      - FB:FBgn0000173
      - MGI:MGI:107412
      - UniProtKB:Q9Y2X8
      - PomBase:SPBC119.02
      - MGI:MGI:109240
      - PomBase:SPCC1259.15c
      - FB:FBgn0264848
      - UniProtKB:P51668
      - PomBase:SPCC338.05c
      - MGI:MGI:2384911
      - FB:FBgn0011217
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      - MGI:MGI:1914049
      - UniProtKB:P61085
      provenances:
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        date: '2025-06-09'
        provided_by:
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    provenances:
    - contributor:
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      date: '2025-06-09'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC211.07c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0061631
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000000738
      provenances:
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        date: '2025-06-09'
        provided_by:
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    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-09'
      provided_by:
      - http://www.pombase.org
    term: GO:0005737
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:35075549
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-09'
        provided_by:
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    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-09'
      provided_by:
      - http://www.pombase.org
    term: GO:0010637
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - UniProtKB:Q8N2K1
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      - WB:WBGene00002344
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      - UniProtKB:P61088
      - WB:WBGene00006713
      - MGI:MGI:2388672
      - MGI:MGI:1917343
      - MGI:MGI:104632
      - UniProtKB:Q9Y385
      - UniProtKB:A1L167
      - UniProtKB:P61077
      - UniProtKB:O00762
      - MGI:MGI:107411
      - UniProtKB:Q9NPD8
      - FB:FBgn0026316
      - UniProtKB:Q969T4
      - UniProtKB:Q96LR5
      - UniProtKB:Q96B02
      - PomBase:SPAC11E3.04c
      - FB:FBgn0000173
      - MGI:MGI:107412
      - UniProtKB:Q9Y2X8
      - PomBase:SPBC119.02
      - MGI:MGI:109240
      - PomBase:SPCC1259.15c
      - FB:FBgn0264848
      - UniProtKB:P51668
      - PomBase:SPCC338.05c
      - MGI:MGI:2384911
      - FB:FBgn0011217
      - UniProtKB:P62837
      - MGI:MGI:1914049
      - UniProtKB:P61085
      provenances:
      - contributor:
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        date: '2025-06-09'
        provided_by:
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    provenances:
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      date: '2025-06-09'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002409
    downstream_activity: gomodel:682fbcd000005519/682fbcd000005834
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - UniProtKB:Q8N2K1
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      - WB:WBGene00002344
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      - UniProtKB:P61088
      - WB:WBGene00006713
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      - MGI:MGI:1917343
      - MGI:MGI:104632
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      - UniProtKB:A1L167
      - UniProtKB:P61077
      - UniProtKB:O00762
      - MGI:MGI:107411
      - UniProtKB:Q9NPD8
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      - UniProtKB:Q96B02
      - PomBase:SPAC11E3.04c
      - FB:FBgn0000173
      - MGI:MGI:107412
      - UniProtKB:Q9Y2X8
      - PomBase:SPBC119.02
      - MGI:MGI:109240
      - PomBase:SPCC1259.15c
      - FB:FBgn0264848
      - UniProtKB:P51668
      - PomBase:SPCC338.05c
      - MGI:MGI:2384911
      - FB:FBgn0011217
      - UniProtKB:P62837
      - MGI:MGI:1914049
      - UniProtKB:P61085
      provenances:
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        date: '2025-06-09'
        provided_by:
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    provenances:
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      date: '2025-06-09'
      provided_by:
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    predicate: RO:0002409
    downstream_activity: gomodel:682fbcd000005519/682fbcd000005834
- id: gomodel:682fbcd000005519/682fbcd000005851
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000303
      reference: GO_REF:0000051
      provenances:
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        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-09'
        provided_by:
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    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-09'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC1B2.02c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0060090
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000002878
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-09'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-09'
      provided_by:
      - http://www.pombase.org
    term: GO:0005741
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN008605439
      - SGD:S000002878
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-09'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-09'
      provided_by:
      - http://www.pombase.org
    term: GO:0008053
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000303
      reference: GO_REF:0000051
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-09'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000303
      reference: GO_REF:0000051
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-09'
        provided_by:
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    provenances:
    - contributor:
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      date: '2025-06-09'
      provided_by:
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    predicate: RO:0012009
    downstream_activity: gomodel:682fbcd000005519/682fbcd000005841
  - type: CausalAssociation
    evidence:
    - term: ECO:0000303
      reference: GO_REF:0000051
      provenances:
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        date: '2025-06-09'
        provided_by:
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    provenances:
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    predicate: RO:0012009
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  - type: CausalAssociation
    evidence: []
    provenances:
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      date: '2025-06-09'
      provided_by:
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    predicate: RO:0012009
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  - type: CausalAssociation
    evidence:
    - term: ECO:0000303
      reference: GO_REF:0000051
      provenances:
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        date: '2025-06-09'
        provided_by:
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    provenances:
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      date: '2025-06-09'
      provided_by:
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    predicate: RO:0012009
    downstream_activity: gomodel:682fbcd000005519/682fbcd000005834
- id: gomodel:682fbcd000005519/682fbcd000005590
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - UniProtKB:Q9NX47
      provenances:
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        date: '2025-06-06'
        provided_by:
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      date: '2025-06-06'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC32F12.07c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0061630
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
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      date: '2025-06-06'
      provided_by:
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    term: GO:0005741
  part_of:
    type: BiologicalProcessAssociation
    evidence: []
    provenances:
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      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-06'
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    term: GO:0090141
  causal_associations:
  - type: CausalAssociation
    evidence: []
    provenances:
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    predicate: RO:0002629
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  - type: CausalAssociation
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  - type: CausalAssociation
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    downstream_activity: gomodel:682fbcd000005519/682fbcd000005520
- id: gomodel:682fbcd000005519/682fbcd000005545
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    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
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      provided_by:
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    term: PomBase:SPAC823.13c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0003674
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    evidence:
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      reference: GO_REF:0000033
      with_objects:
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    term: GO:0005743
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    term: GO:0007007
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    term: PomBase:SPAC30C2.06c
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    - term: ECO:0000250
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    term: GO:0005741
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      provided_by:
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    term: GO:0008053
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    predicate: RO:0002304
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      reference: PMID:9928955
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        provided_by:
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    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - UniProtKB:P27594
      - WB:WBGene00001130
      - TAIR:locus:2165805
      - UniProtKB:O00429
      - RGD:727949
      - UniProtKB:Q05193
      - dictyBase:DDB_G0277849
      - TAIR:locus:2134198
      - MGI:MGI:1921393
      - UniProtKB:O60313
      - SGD:S000005737
      - MGI:MGI:107384
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      - SGD:S000003924
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      - SGD:S000001709
      - RGD:2513
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      provided_by:
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    term: PomBase:SPBC1718.06
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      reference: PMID:19567474
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      provided_by:
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    term: GO:0005743
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      reference: PMID:19567474
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    term: GO:1990627
- id: gomodel:682fbcd000005519/682fbcd000005556
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    - term: ECO:0000315
      reference: PMID:37590302
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    term: PomBase:SPCC24B10.10c
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      with_objects:
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      - SGD:S000003260
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      - UniProtKB:Q8NBU5
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      provided_by:
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    term: GO:0005741
  part_of:
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    - term: ECO:0000269
      reference: PMID:37590302
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    term: GO:0090258
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    predicate: RO:0002630
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  - type: CausalAssociation
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    - term: ECO:0000315
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      reference: PMID:37590302
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    predicate: RO:0002630
    downstream_activity: gomodel:682fbcd000005519/682fbcd000005535
- id: gomodel:682fbcd000005519/682fbcd000005527
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    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
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        - https://orcid.org/0000-0001-6330-7526
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    - contributor:
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      date: '2025-06-06'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC664.15
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0060090
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000003648
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
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        provided_by:
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    - contributor:
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      - http://www.pombase.org
    term: GO:0032473
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN002336496
      - SGD:S000001744
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      provided_by:
      - http://www.pombase.org
    term: GO:0000266
  causal_associations:
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      reference: GO_REF:0000015
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    - term: ECO:0000307
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    predicate: RO:0012009
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  - type: CausalAssociation
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    predicate: RO:0012009
    downstream_activity: gomodel:682fbcd000005519/682fbcd000005535
- id: gomodel:682fbcd000005519/682fbcd000005834
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000255
      reference: GO_REF:0000050
      with_objects:
      - InterPro:IPR001401
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        - https://orcid.org/0000-0001-6330-7526
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    - contributor:
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      date: '2025-06-09'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC1706.03
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0061791
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN002573358
      - UniProtKB:Q8IWA4
      - SGD:S000000383
      - FB:FBgn0029870
      - RGD:621460
      - RGD:628843
      provenances:
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    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-09'
      provided_by:
      - http://www.pombase.org
    term: GO:0005741
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:33125111
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
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      - https://orcid.org/0000-0001-6330-7526
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      provided_by:
      - http://www.pombase.org
    term: GO:1990626
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000255
      reference: GO_REF:0000050
      with_objects:
      - InterPro:IPR001401
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
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    predicate: RO:0012009
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  - type: CausalAssociation
    evidence:
    - term: ECO:0000255
      reference: GO_REF:0000050
      with_objects:
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      provenances:
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      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:682fbcd000005519/682fbcd000005841
objects:
- id: GO:0043495
  label: protein-membrane adaptor activity
  type: gocam:Object
- id: PomBase:SPBC11G11.01
  label: fis1 Spom
  type: gocam:Object
- id: GO:0090149
  label: mitochondrial membrane fission
  type: gocam:Object
- id: GO:0032473
  label: cytoplasmic side of mitochondrial outer membrane
  type: gocam:Object
- id: ECO:0000304
  label: author statement supported by traceable reference used in manual assertion
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: GO:0060090
  label: molecular adaptor activity
  type: gocam:Object
- id: PomBase:SPAC664.15
  label: mdv1 Spom
  type: gocam:Object
- id: GO:0000266
  label: mitochondrial fission
  type: gocam:Object
- id: ECO:0000307
  label: no evidence data found used in manual assertion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: GO:1990606
  label: membrane scission GTPase motor activity
  type: gocam:Object
- id: PomBase:SPBC12C2.08
  label: dnm1 Spom
  type: gocam:Object
- id: GO:0005741
  label: mitochondrial outer membrane
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: GO:0003674
  label: molecular_function
  type: gocam:Object
- id: PomBase:SPAC823.13c
  label: she9 Spom
  type: gocam:Object
- id: GO:0007007
  label: inner mitochondrial membrane organization
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: GO:0140567
  label: membrane protein dislocase activity
  type: gocam:Object
- id: PomBase:SPCC24B10.10c
  label: yta4 Spom
  type: gocam:Object
- id: GO:0090258
  label: negative regulation of mitochondrial fission
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: GO:0061630
  label: ubiquitin protein ligase activity
  type: gocam:Object
- id: PomBase:SPBC32F12.07c
  label: SPBC32F12.07c Spom
  type: gocam:Object
- id: GO:0090141
  label: positive regulation of mitochondrial fission
  type: gocam:Object
- id: GO:0061791
  label: GTPase motor activity
  type: gocam:Object
- id: PomBase:SPBC1706.03
  label: fzo1 Spom
  type: gocam:Object
- id: GO:1990626
  label: mitochondrial outer membrane fusion
  type: gocam:Object
- id: ECO:0000255
  label: match to sequence model evidence used in manual assertion
  type: gocam:Object
- id: GO:0003924
  label: GTPase activity
  type: gocam:Object
- id: PomBase:SPBC1718.06
  label: msp1 Spom
  type: gocam:Object
- id: GO:1990627
  label: mitochondrial inner membrane fusion
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC1B2.02c
  label: ugo1 Spom
  type: gocam:Object
- id: GO:0008053
  label: mitochondrial fusion
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC30C2.06c
  label: dml1 Spom
  type: gocam:Object
- id: GO:0061631
  label: ubiquitin conjugating enzyme activity
  type: gocam:Object
- id: PomBase:SPBC211.07c
  label: ubc8 Spom
  type: gocam:Object
- id: GO:0010637
  label: negative regulation of mitochondrial fusion
  type: gocam:Object
- id: GO:0005737
  label: cytoplasm
  type: gocam:Object
- id: GO:0042149
  label: cellular response to glucose starvation
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2025-06-09'
  provided_by:
  - http://www.pombase.org
