id: gomodel:678073a900002636
title: coenzyme A biosynthetic process (GO:0015937) and acetyl-CoA biosynthetic process
  from acetate (GO:0019427)
taxon: NCBITaxon:4896
status: production
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      - https://orcid.org/0009-0003-9059-1333
      date: '2025-01-22'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:29032
  causal_associations:
  - type: CausalAssociation
    evidence: []
    provenances:
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      date: '2025-01-22'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:678073a900002636/678073a900002749
  - type: CausalAssociation
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      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000957942
      - FB:FBgn0011205
      - TAIR:locus:2116490
      - UniProtKB:Q8ILP4
      - UniProtKB:G5EAY3
      - UniProtKB:Q9BZ23
      - MGI:MGI:1921700
      - MGI:MGI:2387464
      - SGD:S000002939
      - UniProtKB:Q9H999
      - UniProtKB:Q8IL92
      - MGI:MGI:1922985
      - UniProtKB:Q8TE04
      - TAIR:locus:2195638
      provenances:
      - contributor:
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        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - FB:FBgn0011205
      - TAIR:locus:2116490
      - UniProtKB:Q8ILP4
      - UniProtKB:G5EAY3
      - UniProtKB:Q9BZ23
      - MGI:MGI:1921700
      - MGI:MGI:2387464
      - SGD:S000002939
      - UniProtKB:Q9H999
      - UniProtKB:Q8IL92
      - MGI:MGI:1922985
      - UniProtKB:Q8TE04
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      provenances:
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        date: '2025-01-22'
        provided_by:
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      date: '2025-01-22'
      provided_by:
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    predicate: RO:0002413
    downstream_activity: gomodel:678073a900002636/678073a900002749
- id: gomodel:678073a900002636/678073a900002699
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - SGD:S000004143
      - UniProtKB:P27550
      - SGD:S000000050
      - UniProtKB:Q9NUB1
      - RGD:1305489
      - MGI:MGI:1890410
      - UniProtKB:Q8ZKF6
      - CGD:CAL0000197968
      - MGI:MGI:1915988
      - RGD:1306246
      - TAIR:locus:2149104
      - UniProtKB:C6KTB4
      - UniProtKB:Q9NR19
      provenances:
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        date: '2025-01-22'
        provided_by:
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    provenances:
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      date: '2025-01-22'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPCC191.02c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0003987
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
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      - contributor:
        - https://orcid.org/0009-0003-9059-1333
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        provided_by:
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    provenances:
    - contributor:
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      date: '2025-01-22'
      provided_by:
      - http://www.pombase.org
    term: GO:0005739
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000501
      reference: GO_REF:0000002
      with_objects:
      - InterPro:IPR011904
      provenances:
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        - https://orcid.org/0009-0003-9059-1333
        date: '2025-01-22'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-01-22'
      provided_by:
      - http://www.pombase.org
    term: GO:0019427
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  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000644161
      - SGD:S000004143
      - UniProtKB:P27550
      - SGD:S000000050
      - UniProtKB:Q9NUB1
      - RGD:1305489
      - MGI:MGI:1890410
      - UniProtKB:Q8ZKF6
      - CGD:CAL0000197968
      - MGI:MGI:1915988
      - RGD:1306246
      - TAIR:locus:2149104
      - UniProtKB:C6KTB4
      - UniProtKB:Q9NR19
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-01-22'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-01-22'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:30089
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000644161
      - SGD:S000004143
      - UniProtKB:P27550
      - SGD:S000000050
      - UniProtKB:Q9NUB1
      - RGD:1305489
      - MGI:MGI:1890410
      - UniProtKB:Q8ZKF6
      - CGD:CAL0000197968
      - MGI:MGI:1915988
      - RGD:1306246
      - TAIR:locus:2149104
      - UniProtKB:C6KTB4
      - UniProtKB:Q9NR19
      provenances:
      - contributor:
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        date: '2025-06-05'
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    provenances:
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      date: '2025-06-05'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57287
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000644161
      - SGD:S000004143
      - UniProtKB:P27550
      - SGD:S000000050
      - UniProtKB:Q9NUB1
      - RGD:1305489
      - MGI:MGI:1890410
      - UniProtKB:Q8ZKF6
      - CGD:CAL0000197968
      - MGI:MGI:1915988
      - RGD:1306246
      - TAIR:locus:2149104
      - UniProtKB:C6KTB4
      - UniProtKB:Q9NR19
      provenances:
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        - https://orcid.org/0009-0003-9059-1333
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        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-01-22'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57288
- id: gomodel:678073a900002636/678073a900002725
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000075336
      - UniProtKB:Q13057
      - UniProtKB:Q8WVC6
      - UniProtKB:Q8MIR4
      - MGI:MGI:1918993
      - UniProtKB:P9WPA3
      - UniProtKB:P0A6I9
      - UniProtKB:Q8IL34
      - TAIR:locus:2038663
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-01-22'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-01-22'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPCC14G10.01
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004140
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-01-22'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-01-22'
      provided_by:
      - http://www.pombase.org
    term: GO:0005737
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000075336
      - SGD:S000003509
      - SGD:S000002604
      - TAIR:locus:2062165
      - UniProtKB:Q13057
      - UniProtKB:P9WPA3
      - TAIR:locus:2038663
      - UniProtKB:P0A6I9
      - UniProtKB:Q8IL34
      - MGI:MGI:1918993
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-01-22'
        provided_by:
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    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-01-22'
      provided_by:
      - http://www.pombase.org
    term: GO:0015937
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000075336
      - UniProtKB:Q13057
      - UniProtKB:Q8WVC6
      - UniProtKB:Q8MIR4
      - MGI:MGI:1918993
      - UniProtKB:P9WPA3
      - UniProtKB:P0A6I9
      - UniProtKB:Q8IL34
      - TAIR:locus:2038663
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-01-22'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-01-22'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57287
objects:
- id: GO:0003987
  label: acetate-CoA ligase activity
  type: gocam:Object
- id: PomBase:SPCC191.02c
  label: acs1 Spom
  type: gocam:Object
- id: GO:0019427
  label: acetyl-CoA biosynthetic process from acetate
  type: gocam:Object
- id: GO:0005739
  label: mitochondrion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000501
  label: evidence used in automatic assertion
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:58342
  label: acyl-CoA(4-)
  type: gocam:Object
- id: GO:0008775
  label: acetate CoA-transferase activity
  type: gocam:Object
- id: PomBase:SPAC1952.09c
  label: ach1 Spom
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0004140
  label: dephospho-CoA kinase activity
  type: gocam:Object
- id: PomBase:SPCC14G10.01
  label: cab5 Spom
  type: gocam:Object
- id: GO:0015937
  label: coenzyme A biosynthetic process
  type: gocam:Object
- id: GO:0005737
  label: cytoplasm
  type: gocam:Object
- id: GO:0004595
  label: pantetheine-phosphate adenylyltransferase activity
  type: gocam:Object
- id: PomBase:SPAC1F12.08
  label: cab4 Spom
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: GO:0004633
  label: phosphopantothenoylcysteine decarboxylase activity
  type: gocam:Object
- id: PomBase:SPAC15E1.04
  label: hal3 Spom
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: GO:0004632
  label: phosphopantothenate--cysteine ligase activity
  type: gocam:Object
- id: PomBase:SPCC4B3.18
  label: ppc1 Spom
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: GO:0004594
  label: pantothenate kinase activity
  type: gocam:Object
- id: PomBase:SPBC4B4.01c
  label: ptk1 Spom
  type: gocam:Object
- id: CHEBI:29032
  label: (R)-pantothenate
  type: gocam:Object
- id: PomBase:SPAC4A8.11c
  label: fas2 Spom
  type: gocam:Object
- id: CHEBI:57287
  label: coenzyme A(4-)
  type: gocam:Object
- id: CHEBI:30089
  label: acetate
  type: gocam:Object
- id: CHEBI:57288
  label: acetyl-CoA(4-)
  type: gocam:Object
- id: GO:0015228
  label: coenzyme A transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC17H9.08
  label: leu5 Spom
  type: gocam:Object
- id: GO:1990559
  label: mitochondrial coenzyme A transmembrane transport
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: CHEBI:35235
  label: L-cysteine zwitterion
  type: gocam:Object
- id: CHEBI:29067
  label: carboxylic acid anion
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0009-0003-9059-1333
  date: '2025-06-09'
  provided_by:
  - http://www.pombase.org
