id: gomodel:66c7d41500002088
title: ergosterol biosynthetic process (GO:0006696), intracellular sterol transport
  (GO:0032366)
taxon: NCBITaxon:4896
status: production
comments:
- note that squalene synthase is a 2-step reaction with intermediate presqualene
activities:
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    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
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      date: '2025-04-15'
      provided_by:
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    term: PomBase:SPBPB2B2.02
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0034084
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
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      reference: GO_REF:0000051
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    term: GO:0098553
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    term: GO:0008204
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  enabled_by:
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      date: '2024-09-10'
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    term: PomBase:SPAC1687.16c
  molecular_function:
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    term: GO:0000248
  occurs_in:
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    evidence:
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      reference: GO_REF:0000024
      with_objects:
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    term: GO:0005789
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:18310029
      with_objects:
      - PomBase:SPBC27B12.03c
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    - term: ECO:0000316
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      date: '2024-09-10'
      provided_by:
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    term: GO:0006696
  causal_associations:
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- id: gomodel:66c7d41500002088/66c7d41500002138
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    term: PomBase:SPBC16E9.05
  molecular_function:
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  occurs_in:
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      - http://www.pombase.org
    term: PomBase:SPAC25B8.01
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      - http://www.pombase.org
    term: GO:0005789
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objects:
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  label: 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity
  type: gocam:Object
- id: PomBase:SPBC3F6.02c
  label: erg26 Spom
  type: gocam:Object
- id: GO:0006696
  label: ergosterol biosynthetic process
  type: gocam:Object
- id: GO:0005783
  label: endoplasmic reticulum
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0004506
  label: squalene monooxygenase activity
  type: gocam:Object
- id: PomBase:SPBC713.12
  label: erg1 Spom
  type: gocam:Object
- id: GO:0005789
  label: endoplasmic reticulum membrane
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: GO:0000250
  label: lanosterol synthase activity
  type: gocam:Object
- id: PomBase:SPAC13G7.01c
  label: erg7 Spom
  type: gocam:Object
- id: GO:0003838
  label: sterol 24-C-methyltransferase activity
  type: gocam:Object
- id: PomBase:SPBC16E9.05
  label: erg6 Spom
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: GO:0008398
  label: sterol 14-demethylase activity
  type: gocam:Object
- id: PomBase:SPAC13A11.02c
  label: erg11 Spom
  type: gocam:Object
- id: GO:0000253
  label: 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity
  type: gocam:Object
- id: PomBase:SPBC1709.07
  label: erg27 Spom
  type: gocam:Object
- id: GO:0000247
  label: C-8 sterol isomerase activity
  type: gocam:Object
- id: PomBase:SPAC20G8.07c
  label: erg2 Spom
  type: gocam:Object
- id: GO:0000248
  label: C-5 sterol desaturase activity
  type: gocam:Object
- id: PomBase:SPAC1687.16c
  label: erg31 Spom
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: GO:0000249
  label: C-22 sterol desaturase (NADPH) activity
  type: gocam:Object
- id: PomBase:SPAC19A8.04
  label: erg5 Spom
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: GO:0000246
  label: Delta24(24-1) sterol reductase activity
  type: gocam:Object
- id: PomBase:SPAC20G4.07c
  label: erg4 Spom
  type: gocam:Object
- id: GO:0050613
  label: Delta14-sterol reductase activity
  type: gocam:Object
- id: PomBase:SPBC16G5.18
  label: erg24 Spom
  type: gocam:Object
- id: CHEBI:17813
  label: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
  type: gocam:Object
- id: GO:0000254
  label: C-4 methylsterol oxidase activity
  type: gocam:Object
- id: PomBase:SPAC630.08c
  label: erg25 Spom
  type: gocam:Object
- id: CHEBI:18364
  label: 14-demethyllanosterol
  type: gocam:Object
- id: GO:0051996
  label: squalene synthase [NAD(P)H] activity
  type: gocam:Object
- id: PomBase:SPBC646.05c
  label: erg9 Spom
  type: gocam:Object
- id: GO:0098554
  label: cytoplasmic side of endoplasmic reticulum membrane
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:16933
  label: ergosterol
  type: gocam:Object
- id: GO:0045337
  label: farnesyl diphosphate biosynthetic process
  type: gocam:Object
- id: GO:0030674
  label: protein-macromolecule adaptor activity
  type: gocam:Object
- id: PomBase:SPBC337.09
  label: erg28 Spom
  type: gocam:Object
- id: PomBase:SPBC27B12.03c
  label: erg32 Spom
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: GO:0034737
  label: ergosterol O-acyltransferase activity
  type: gocam:Object
- id: PomBase:SPAC13G7.05
  label: are1 Spom
  type: gocam:Object
- id: GO:0008204
  label: ergosterol metabolic process
  type: gocam:Object
- id: PomBase:SPCP1E11.05c
  label: are2 Spom
  type: gocam:Object
- id: GO:0003958
  label: NADPH-hemoprotein reductase activity
  type: gocam:Object
- id: PomBase:SPBC29A10.01
  label: ccr1 Spom
  type: gocam:Object
- id: CHEBI:16521
  label: lanosterol
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: CHEBI:175763
  label: 2-trans,6-trans-farnesyl diphosphate(3-)
  type: gocam:Object
- id: CHEBI:15440
  label: squalene
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: GO:0120015
  label: sterol transfer activity
  type: gocam:Object
- id: PomBase:SPBC20F10.07
  label: ltc1 Spom
  type: gocam:Object
- id: GO:0120011
  label: intermembrane sterol transfer
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: GO:0055092
  label: sterol homeostasis
  type: gocam:Object
- id: GO:0005741
  label: mitochondrial outer membrane
  type: gocam:Object
- id: GO:0140268
  label: endoplasmic reticulum-plasma membrane contact site
  type: gocam:Object
- id: GO:0005886
  label: plasma membrane
  type: gocam:Object
- id: CHEBI:52320
  label: ergosteryl ester
  type: gocam:Object
- id: GO:0034084
  label: steryl deacetylase activity
  type: gocam:Object
- id: PomBase:SPBPB2B2.02
  label: say1 Spom
  type: gocam:Object
- id: GO:0098553
  label: lumenal side of endoplasmic reticulum membrane
  type: gocam:Object
- id: GO:0008047
  label: enzyme activator activity
  type: gocam:Object
- id: PomBase:SPAC25B8.01
  label: dap1 Spom
  type: gocam:Object
- id: GO:0009055
  label: electron transfer activity
  type: gocam:Object
- id: PomBase:SPCC16A11.10c
  label: oca8 Spom
  type: gocam:Object
- id: GO:0004128
  label: cytochrome-b5 reductase activity, acting on NAD(P)H
  type: gocam:Object
- id: PomBase:SPCC970.03
  label: cbr1 Spom
  type: gocam:Object
- id: PomBase:SPBC29A10.16c
  label: cyb502 Spom
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2025-04-30'
  provided_by:
  - http://www.pombase.org
