id: gomodel:663d668500001911
title: '''de novo'' IMP biosynthetic process (GO:0006189)'
taxon: NCBITaxon:4896
status: production
activities:
- id: gomodel:663d668500001911/663d668500001954
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:8346915
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2024-05-22'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2024-05-22'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC409.10
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004639
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000176702
      - CGD:CAL0000196632
      - SGD:S000000070
      provenances:
      - contributor:
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        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: GO:0006189
  has_input:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:8346915
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:29991
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:8346915
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2024-05-22'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2024-05-22'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:663d668500001911/663d668500001960
- id: gomodel:663d668500001911/663d668500001966
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:9802209
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2024-05-22'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:24186301
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2024-05-22'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2024-05-22'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPCPB16A4.03c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004643
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000190296
      - SGD:S000004018
      - UniProtKB:P15639
      - SGD:S000004727
      - UniProtKB:P31939
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
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    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:24186301
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000190296
      - MGI:MGI:1351352
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      - UniProtKB:P31939
      - RGD:70879
      - SGD:S000004018
      - SGD:S000004727
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: GO:0006189
  has_input:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000055290
      - TAIR:locus:2029554
      - SGD:S000002816
      - UniProtKB:P08179
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:195366
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:9802209
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-07-18'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:24186301
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-07-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-07-18'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:58475
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:9802209
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:24186301
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57453
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:9802209
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-07-21'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:24186301
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-07-21'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-07-21'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:58467
- id: gomodel:663d668500001911/663d668500001960
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:8346915
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2024-05-22'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2024-05-22'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC14F5.09c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0070626
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000154581
      - UniProtKB:P30566
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004351
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: GO:0006189
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:8346915
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:29806
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:8346915
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-07-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-07-18'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:58475
- id: gomodel:663d668500001911/663d668500001933
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN008493809
      - SGD:S000003293
      - FB:FBgn0000052
      - UniProtKB:O15067
      - UniProtKB:P15254
      provenances:
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        - https://orcid.org/0009-0003-9059-1333
        date: '2024-05-22'
        provided_by:
        - http://www.pombase.org
    provenances:
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      - https://orcid.org/0009-0003-9059-1333
      date: '2024-05-22'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC6F12.10c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004642
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:10759889
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - PomBase:SPAC6F12.10c
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      provenances:
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        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: GO:0005737
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000269
      reference: PMID:17248775
      provenances:
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        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
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      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: GO:0006189
  has_input:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN008493809
      - SGD:S000003293
      - FB:FBgn0000052
      - UniProtKB:O15067
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      provenances:
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        date: '2025-07-21'
        provided_by:
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    provenances:
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      date: '2025-07-21'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:147286
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:4371850
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
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    provenances:
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      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:58359
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN008493809
      - SGD:S000003293
      - FB:FBgn0000052
      - UniProtKB:O15067
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      provenances:
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        date: '2025-04-28'
        provided_by:
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    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:29985
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN008493809
      - SGD:S000003293
      - FB:FBgn0000052
      - UniProtKB:O15067
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      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2024-05-22'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
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      date: '2024-05-22'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:663d668500001911/663d668500001940
- id: gomodel:663d668500001911/663d668500001940
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:3502942
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2024-05-22'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:967158
      provenances:
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        date: '2024-05-22'
        provided_by:
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    provenances:
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      date: '2024-05-22'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC405.01
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004641
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      provenances:
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      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:3502942
      provenances:
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      provided_by:
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    term: GO:0006189
  causal_associations:
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    - term: ECO:0000314
      reference: PMID:967158
      provenances:
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    predicate: RO:0002413
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- id: gomodel:663d668500001911/680ad14200000971
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    evidence:
    - term: ECO:0000318
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      with_objects:
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    provenances:
    - contributor:
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      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC2G2.08
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004477
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - SGD:S000001788
      provenances:
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    provenances:
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      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000250
      reference: GO_REF:0000024
      with_objects:
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      provenances:
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      provided_by:
      - http://www.pombase.org
    term: GO:0009257
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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objects:
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  type: gocam:Object
- id: PomBase:SPBC2G2.08
  label: ade9 Spom
  type: gocam:Object
- id: GO:0009257
  label: 10-formyltetrahydrofolate biosynthetic process
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:57453
  label: (6S)-5,6,7,8-tetrahydrofolate(2-)
  type: gocam:Object
- id: CHEBI:29991
  label: L-aspartate(1-)
  type: gocam:Object
- id: CHEBI:29806
  label: fumarate(2-)
  type: gocam:Object
- id: CHEBI:195366
  label: (6R)-10-formyltetrahydrofolate(2-)
  type: gocam:Object
- id: GO:0031012
  label: extracellular matrix
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:143788
  label: N(1)-(5-phospho-beta-D-ribosyl)glycinamide(1-)
  type: gocam:Object
- id: CHEBI:58475
  label: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
  type: gocam:Object
- id: CHEBI:147286
  label: N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide(2-)
  type: gocam:Object
- id: CHEBI:58467
  label: 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0009-0003-9059-1333
  date: '2025-07-21'
  provided_by:
  - http://www.pombase.org
