ID SPCC962 standard; DNA; FUN; 16137 BP. XX AC AL031323; XX SV AL031323.1 XX DT 21-AUG-1998 (Rel. 56, Created) DT 16-FEB-2000 (Rel. 62, Last updated, Version 2) XX DE S.pombe chromosome III cosmid c962. XX KW 40s ribosomal protein s12; Armadillo/beta-catenin-like repeats; KW C2 domain family protein; human splicing factor SF1 homologue; KW human transcription factor ZFM1 homologue; KW importin alpha subunit, serine rich RNA polymerase I supressor; KW Inhibitor of Apoptosis domain containing protein; rps12-1. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-16137 RA Harris D., Wood V., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (20-AUG-1998) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; O14062; O14062. DR GOA; O14063; O14063. DR GOA; O14064; O14064. DR GOA; O14065; O14065. DR GOA; O74555; O74555. DR SPTREMBL; O74555; O74555. DR SWISS-PROT; O14061; YC35_SCHPO. DR SWISS-PROT; O14062; R12A_SCHPO. DR SWISS-PROT; O14063; IMA1_SCHPO. DR SWISS-PROT; O14064; BIR1_SCHPO. DR SWISS-PROT; O14065; YC31_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 80% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c962 is overlapped by cosmids c2C6 and cosmid c1672. XX FH Key Location/Qualifiers FH FT source 1..16137 FT /chromosome="III" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c962" FT /map="IIIL" FT CDS 1..1545 FT /codon_start=1 FT /db_xref="GOA:O14065" FT /db_xref="SWISS-PROT:O14065" FT /label=SPCC962.01 FT /note="SPCC962.01, len:514aa, similarity: YML072C, YMH2_YE FT AST, hypothetical 171.1 kd protein, (1545aa), fasta scores, FT opt:435, E():1.9e-06, (25.6% identity in 539 aa overlap)" FT /partial FT /gene="SPCC962.01" FT /product="C2 domain family protein" FT /gene="SPCP31B10.09" FT /protein_id="CAA20433.1" FT /translation="DPTTPAKDNSTSNAETSSITSVISVNEALQYPSGFALISIVSADL FT QDVGVDLRVFTDNAAFPFITTPIAKTKTPRWSSFGISMVRELQFSETTFQLTDGAKKDP FT KVVCEHSVKTLDLVSEALGRPYSVEIPGSNGQLNHVRLSITYMPVPMTLNPMESYINSG FT SLHFMLQDGQNLPIGDIRSSDPFVVLKLNGESAFKSKVIKKNLNPVWNEEADIVVQNRV FT LDVLELVCYDWDMGEKPDVLGTSNIDLLSLEPNVESQQSIKLDSKTGTINASLRFVPGW FT HRRKAVLDVTLADNFLHAANKGAKLVVGGVGAAGGLALAGVTTIGSVGSKAVTGVADGV FT TGTGKHIISGAKGISKMGMFRRSLEKNPSRSDLTTTQEASSSASVPPAIAPESANAALT FT STIDKTTGAPELAQKKYKVYVGQGKNMPHKTIKIIVTDNQDHSFKTKSRKGPSPSWNEE FT IPVKWSLGDELRISAVTSNLLGHTKLGEAVFQEDAIGTFRVVIGGSSSVEIKVEAE" FT misc_feature 1..2109 FT /note="nominal overlap with plasmid SPAP31B10, EM:AL121859 FT S. pombe chromosome 3" FT misc_feature 307 FT /note="left end of c2C6 (which originally had a chromosome FT I allocation) the right hand end of c2C6 is in cosmid c1672 FT " FT misc_feature 493..738 FT /note="Pfam match to entry PF00168 C2, C2 domain" FT misc_feature 514..729 FT /note="Match to PF00168 C2, C2 domain Score 60.20" FT CDS join(complement(4821..4949),complement(1909..4773)) FT /db_xref="GOA:O14064" FT /db_xref="SWISS-PROT:O14064" FT /label=cut17 FT /note="SPCC962.02c, len:997aa" FT /gene="SPCC962.02c" FT /gene="cut17" FT /gene="SPCP31B10.10c" FT /product="cut17p" FT /protein_id="CAA20434.1" FT /translation="MKPITSSSKRRWNRFRREMCNYSKRLDTFQKKKWPRAKPTPETLA FT TVGFYYNPISESNSEERLDNVTCYMCTKSFYDWEDDDDPLKEHITHSPSCPWAYILSSK FT NNPNQNPQAAALTKCREQTFVDKVWPYTNRPDYHCEPSVMAASGFVYNPTADAKDAAHC FT LYCDINLHDWEPDDDPYTEHKRRRADCVFFTWKDPNSLSPTKLSFLSTSNIDPEDLTED FT NSILPVSPTRDSTKSHKTLNFSPSRKNNLNARPLTMSLYTNTSEEKDSQPTRAPQSPTK FT PVLLTAPRRKNKSPKKSKPAVFKPVKPIFSDEDEDDDDLTASQPFSKGICNDSMQVAKK FT NFTEEIPLKEDEKDNELEHLVSPATSVHTTVSDITGHQSVTDESDEQNNCMSTPPKIEI FT ESKIEEEISVVSKSKEISSSVSSVGKEQNHTEKQVAIETPEQQKVEKEDEHLNLQGSFI FT EESTKQPISSKPSTSSPDMTDAATGGRVSSSSFRDKILQTNFSPRSTIDSFSNISKKRN FT SEEANDENDETNLKIPIPEKKRKFQEVLQSKNILVSSTEDSHEPVKVTEDSQTAIHVSK FT FEDLENKSMESEQSLQLLSESENDDKPLIDLIPLLAIKRKDNLVSGVLEKGKSTSTSKT FT KFDTSIVDFIEKPKTEISEVLPEEKRKAICDESQTVRVSIDRGVTKTRDVSSPVSDEKS FT ENVNHEEANSGHTVMNVHSSLDPQPIVQPNELESGSYLKDLPDRNVGNSEKVTFQEDDI FT NSPKLQSKNNQTVEAVNTETSDKLQEKEANHELENIEKIEEKLTEVDKVSLSDAFPDQE FT IKNSRTSVQNGTRSVSKNTPEKETKVDKIDNVSKKDVETSPGSCETSSAFAKTYAEKEV FT TSINLPSVRKPLDESYYDHSISPFDPLCQSSFLAPQTPVKSKHALPLVEANAPPWEPID FT FSSLLESPVPNPVEPNKLSEKELDMTVEQWIKFMYAKCAKEFEEACEEKIEWLLEEGKR FT AEEYIQNL" FT misc_feature complement(3016..3039) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature complement(4324..4545) FT /note="Match to PF00653 BIR, Inhibitor of Apoptosis domain FT Score 121.52" FT misc_feature join(complement(4821..4877),complement(4606..4773)) FT /note="Match to PF00653 BIR, Inhibitor of Apoptosis domain FT Score 83.05" FT misc_feature complement(4774..4788) FT /note="ctaacaagaaaatag, splice branch and acceptor" FT misc_feature complement(4815..4820) FT /note="gtatgt, splice donor sequence" FT CDS complement(6274..7902) FT /db_xref="GOA:O14063" FT /db_xref="SWISS-PROT:O14063" FT /label=cut15 FT /note="SPCC962.03c, len:542aa" FT /gene="cut15" FT /gene="SPCC962.03c" FT /product="importin alpha subunit, serine rich RNA polymera FT se I supressor" FT /protein_id="CAA20435.1" FT /translation="MSASSRFIPEHRRQNYKGKGTFQADELRRRRETQQIEIRKQKREE FT NLNKRRNLVDVQEPAEETIPLEQDKENDLELELQLPDLLKALYSDDIEAQIQATAKFRK FT ALSKETNPPIQKVIDAGVVPRFVEFLSHENNLLKFEASWALTNVASGSSNQTHVVVEAN FT AVPVFVSLLSSSEQDVREQAVWALGNIAGDSPMCRDHVLQCGVLEPLLNIIESNRRLSM FT LRNSTWTLSNMCRGKNPQPDWNSISQVIPVLSKLIYTLDEDVLVDALWAISYLSDGANE FT KIQAIIDAGIPRRLVELLMHPSAQVQTPALRSVGNIVTGDDVQTQVIINCGALSALLSL FT LSSPRDGVRKEACWTISNITAGNSSQIQYVIEANIIPPLIHLLTTADFKIQKEACWAIS FT NATSGGARRPDQIRYLVEQGAIKPLCNLLACQDNKIIQVALDGIENILRVGELDRANNP FT DKINLYAVYVEDAGGMDLIHECQNSSNSEIYQKAYNIIEKFFGEEDEIEELEPETVGDT FT FTFGTTQEPAGDFQFSATNAEDMAM" FT misc_feature complement(6559..6681) FT /note="Match to PF00514 Armadillo_seg, FT Armadillo/beta-catenin-like repeats Score 40.76" FT misc_feature complement(6694..6816) FT /note="Match to PF00514 Armadillo_seg, FT Armadillo/beta-catenin-like repeats Score 71.36" FT misc_feature complement(6820..6933) FT /note="Match to PF00514 Armadillo_seg, FT Armadillo/beta-catenin-like repeats Score 60.11" FT misc_feature complement(6946..7065) FT /note="Match to PF00514 Armadillo_seg, FT Armadillo/beta-catenin-like repeats Score 38.08" FT misc_feature complement(7072..7158) FT /note="Match to PF00514 Armadillo_seg, FT Armadillo/beta-catenin-like repeats Score 27.45" FT misc_feature complement(7198..7323) FT /note="Match to PF00514 Armadillo_seg, FT Armadillo/beta-catenin-like repeats Score 32.67" FT misc_feature complement(7327..7443) FT /note="Match to PF00514 Armadillo_seg, FT Armadillo/beta-catenin-like repeats Score 56.84" FT misc_feature complement(7453..7575) FT /note="Match to PF00514 Armadillo_seg, FT Armadillo/beta-catenin-like repeats Score 41.93" FT misc_feature complement(7600..7893) FT /note="Match to PF01749 IBB, Importin beta binding domain FT Score 152.78" FT LTR complement(8626..8764) FT /note="LTR fragment" FT CDS join(8986..9366,9449..9505) FT /db_xref="GOA:O14062" FT /db_xref="SWISS-PROT:O14062" FT /label=rps12-1 FT /note="SPCC962.04, len:145aa" FT /gene="rps12-1" FT /gene="SPCC962.04" FT /product="40s ribosomal protein s12" FT /protein_id="CAA20436.1" FT /translation="MSEQGDQIEQVDVVEEVEVEAAAPETVSVEDALKEVLKRALVHDG FT LARGIREASKALDRRQAHLCVLCESCDQEAYVKLVEALCAESETPLIKVADPKVLGEWA FT GLCVLDRDGNARKVVGCSCVAVTDYGEDSAALQKLLESFSA" FT misc_feature join(9040..9366,9449..9499) FT /note="Match to PF01164 Ribosomal_S12e, Ribosomal protein FT S12e Score 235.29" FT misc_feature 9079..9123 FT /note="PS01189 Ribosomal protein S12e signature" FT misc_feature 9367..9372 FT /note="gtaagt, splice donor sequence" FT intron 9367..9448 FT /note="confirmed intron" FT misc_feature 9433..9448 FT /note="ctaacatgtaatttag, splice branch and acceptor" FT CDS join(10322..10523,10593..12001) FT /db_xref="SWISS-PROT:O14061" FT /label=SPCC962.05 FT /note="SPCC962.05, len:536aa" FT /gene="SPCC962.05" FT /product="hypothetical protein" FT /protein_id="CAA20437.1" FT /translation="MGVPRLGRFLEPFGKPVYFSSYPEVPLNCSLVIDGPSFAFWLWFS FT QGIVCSDFQGYQKAVLDFHHLLTPLVVCIMDYHNDLFLTYSLSNAYREYIFDGGLPFSK FT HQVRVNRYQQKINDLRSAYINLCVPIAQHVLMGLAKAKVIVCNEEADKYCAFQAKKLDA FT VILSQDSDFLLYDIDTPHYGYIPLQSLDVTSNGISGRKYRFDEIQKDFHFDLHILAAYL FT GVEGHPLDLVIDYHNTFEHICKILENSVKDKFIEKLVSKEELTRVHAFYSLNDLKLETS FT TINTFMWGRVQELLNSQLQPAEIWLPQLLELPSKHCSWLESAPLRLQAYANFSKQMPEF FT GTEVLEYFRLSDRLSKRLISVDYDYATVCETLDSKFSNWNLPHRLVLWTLRCMKNLNNI FT TATSFLLMHVSLFLGSPMNLQPVEPTQEDIASVSRFIATIYSICMLIFSEDKEQSSISF FT QEFVSFSPLSSTLNFALFHQAASKLKTGKSPLSIVTDKTTASLTYKMYKDLTNDYSDIY FT MIMDIWKPKRKRKTKKDQS" FT misc_feature 10524..10529 FT /note="gtaggt, splice donor sequence" FT misc_feature 10583..10592 FT /note="ttaattgaag, splice branch and acceptor" FT CDS join(complement(13976..14006),complement(12197..13929)) FT /db_xref="GOA:O74555" FT /db_xref="SPTREMBL:O74555" FT /label=bpb1 FT /note="SPCC962.06c, len:587aa, similarity: H. sapiens, Q927 FT 45, Mammalian splicing factor SF1, (639aa), fasta scores, o FT pt:1053, E():1.3e-30, (36.8% identity in 532 aa overlap)" FT /gene="SPCC962.06c" FT /product="putative transcription or splicing factor" FT /gene="bpb1" FT /gene="sf1" FT /protein_id="CAA20438.1" FT /translation="MLNSRSVGSTGSNNTPLGRRRFDEKPDSLPPLPDANGMSNGYRDS FT YKSNSRMDHRPDGYHDGRGRRAYRKHYWGHPTPIEEMLPSQMELETAVKSCMTMEQLEL FT YSLNVRLEEITQKLRTGDVVPHHRERSPSPPPQYDNHGRRLNTREIRYKKKLEDERHRI FT IERAMKMVPGFRAPSDYRRPAKTQEKVYVPVKDYPEINFIGLLIGPRGHTLKDMEAKSG FT AKIAIRGKGSVKEGKGRSDPSVRGNMEEDLHCLVTADSEDKINHAIKLIDNVIQTAASV FT PEGQNDLKRNQLRQLATLNGTLRDDENQVCQNCGNVGHRRFDCPERINHTMNIVCRHCG FT SIGHIARDCPVRDQQPPMADSTADREYQSLMQELGGGSAISNGNGEPQKSIEFSESGAA FT SPQAGHPPPWAAASTSVSSSTSSPAPWAKPASSAAPSNPAPWQQPAAPQSAPALSMNPS FT SLPPWQQPTQQSAVQPSNLVPSQNAPFIPGTSAPLPPTTFAPPGVPLPPIPGAPGMPNL FT NMSQPPMVPPGMALPPGMPAPFPGYPAVPAMPGIPGATAPPGAPGSYNTSESSNLNAPP FT GVSMPNGYSNR" FT misc_feature complement(12911..12961) FT /note="Match to PF00098 zf-CCHC, Zinc finger, CCHC class FT Score 29.72" FT misc_feature complement(13029..13082) FT /note="Pfam match to entry PF00098 zf-CCHC, Zinc finger, FT CCHC class, score 15.80, E-value 0.061" FT misc_feature complement(13256..13360) FT /note="Match to PF00013 KH-domain, KH domain Score 21.92" FT misc_feature complement(13930..13942) FT /note="ttaatatttttag, splice branch and acceptor" FT intron complement(13930..13975) FT /note="confirmed intron" FT misc_feature complement(13970..13975) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(14231..14240) FT /note="discrepancy: in cosmid c2C2 this has only 9 A's" FT misc_feature 14290..16137 FT /note="nominal overlap with cosmid SPCC1672, EM:AL031324 S. FT pombe chromosome 3" FT misc_feature join(15868..15899,16016..16137) FT /label=SPCC962.07 FT /note="SPCC962.07, for complete CDS see SPCC1672.01 cosmid FT c1672" XX SQ Sequence 16137 BP; 4885 A; 2937 C; 3151 G; 5164 T; 0 other; gatccgacta cccccgcgaa ggacaatagt acatccaacg ctgagacgtc tagcattact 60 tccgttatca gtgtcaacga agcacttcaa tatccctctg gatttgcact gatatcaatc 120 gtttctgctg atctgcaaga tgtcggtgtt gatttgcgtg tttttacaga taatgcggct 180 tttcctttta ttacaacacc aattgctaaa accaaaactc ctcgttggtc atcatttggt 240 atttctatgg ttcgagagtt acaattttcg gaaactactt ttcagttgac tgacggtgcc 300 aaaaaggatc ccaaagtagt gtgtgagcat agtgtaaaaa ctctcgatct tgtctctgaa 360 gcgctaggtc ggccatattc tgttgagata ccgggtagca atggtcaact taatcacgta 420 agattatcga ttacttacat gccagtacca atgacactga atcctatgga aagctatatc 480 aacagcggtt ctcttcactt tatgttgcag gatggacaaa acctaccaat tggcgacatc 540 cgatcatctg atccttttgt tgtgttgaag ttgaatggtg aaagtgcatt taaaagcaaa 600 gtgattaaga agaacttaaa tcctgtctgg aatgaagagg ctgacattgt agtgcaaaat 660 cgagttttgg atgttttgga attggtttgt tatgattggg acatgggtga aaaaccagat 720 gttttgggaa cgagtaatat tgatttgtta tcgcttgaac cgaacgttga gtctcagcaa 780 tcgattaagt tggactcaaa gactggtaca atcaatgcat ctttgcgctt tgtacctgga 840 tggcatcgtc gcaaagcagt actggatgtc acactagcag ataatttctt acacgctgct 900 aataagggag ctaaattagt agttggcggc gtaggagctg ctggaggttt agctctcgca 960 ggtgttacta ctattggctc ggtaggtagt aaagctgtaa cgggggttgc tgatggagtc 1020 actggaactg gtaaacatat aatttcgggc gcaaaaggaa tttccaaaat gggcatgttt 1080 aggcgttcct tggaaaagaa tccatctcgc tctgatctca cgacaaccca ggaagcttct 1140 tcttctgctt ctgtgccacc ggctattgca cctgagtctg caaacgctgc cttaactagc 1200 actattgaca agactacggg agcacctgaa ttggcacaga aaaagtataa agtatacgtt 1260 ggtcaaggta aaaatatgcc tcataagact ataaagatta tcgttacaga caatcaagac 1320 cacagcttta aaaccaaatc tcggaaaggc ccgtctccct catggaacga agagattccg 1380 gtcaaatgga gtttgggtga cgaacttcga atttcagccg ttacttccaa cttgcttgga 1440 catactaaac tgggtgaagc ggtatttcaa gaagatgcta ttggtacatt tagggttgta 1500 attggtggtt catcttctgt tgaaattaag gtcgaagctg agtagtatgg gtaatgcttc 1560 cggttctttt caacgttcgt tatactttac tttcactatc ttgttgttta attcattcta 1620 ttcatattga ctcaaatata gtaccatatt tgtatattgt gctgccaaaa aaataaatac 1680 tataagaaga attattaaga ctacatcacc agattagcgt agtgttgata taaatacaga 1740 taataagagg atccgattaa caaaacaaga aacataaaag aaaaagaaag aaaaggacgc 1800 tgacagtgca ttcagacaaa tttagttcac attactttaa aatgtagccc gccaacattt 1860 tcgcttaaag cgagacggtc cataaataca gaaacacaat atgtaaaatt ataagttttg 1920 tatgtattct tccgcccgct taccttcttc cagtaaccat tctatttttt cttcacaggc 1980 ttcttcaaac tcttttgcac atttagcata cataaattta atccactgct caacggtcat 2040 atccagttct ttttcactta gtttgtttgg ctctacagga ttcggtactg gagattctaa 2100 tagactcgag aaatctatgg gttcccatgg tggtgcattt gcttcaacta agggcaaagc 2160 atgttttgat ttgacaggag tttgaggagc caaaaatgaa gattggcaca atggatcaaa 2220 tggactgatc gaatggtcat agtaggattc atctaaaggc ttccggacac ttggcaaatt 2280 tatactcgtt acttctttct cagcgtaagt tttagcgaaa gctgaagagg tttcacaaga 2340 accaggtgaa gtttcaacat cctttttact tacattatcg attttatcta ccttcgtttc 2400 cttctcaggt gtatttttcg acactgatct agtaccattc tgtacagaag tcctagaatt 2460 tttgatttct tgatcaggaa aagcatcact taacgagact ttgtctacct cagtcaattt 2520 ttcttcaatc ttttcaatat tttctaattc atggttggcc tccttttctt gcaatttatc 2580 agaagtttct gtattaacag cttcaacggt ttgattgttc ttgctctgta gcttaggaga 2640 attaatgtca tcttcttgaa atgtcacttt ttcggagttt ccgacgtttc tgtcaggaag 2700 atcctttaag taacttcctg attcaagttc attgggttgt acgatcggct ggggatccag 2760 gcttgaatga acattcatga cagtatgacc agaattagct tcctcatgat taacattttc 2820 acttttttca tcggaaacag gacttgatac gtctctcgtc ttggtcactc ctctatctat 2880 agaaactcta accgtttggg actcatcgca aatggccttt cttttttcct caggaagcac 2940 ttcgctaatt tcagtttttg gtttttctat aaagtccact attgatgtat caaactttgt 3000 ttttgatgtt gaggtacttt ttcccttctc taaaactccg cttacaagat tatccttcct 3060 tttaattgct aagagaggaa ttagatcaat taaaggtttg tcatcatttt cagattcaga 3120 aagcaattgt agtgactgtt cagactccat actcttattc tcaagatcct caaatttact 3180 aacgtgaatg gcagtttggc tgtcctctgt aacttttact ggttcatgtg aatcctcagt 3240 agacgaaact aaaatgtttt tagattgtaa aacttcttga aattttctct tcttttcagg 3300 aattggtatt ttcaaattgg tctcgtcatt ttcatcattt gcttcttccg agtttctctt 3360 ttttgaaatg ttgctaaacg aatctattgt actccttggt gaaaaattgg tttgtaatat 3420 tttatctctg aagcttgaag aagacactct acctcctgtt gcagcatcag tcatatcggg 3480 agatgaagtt gatggctttg aagagattgg ttgttttgtg gactcctcta tgaacgaacc 3540 ttgaagattt aaatgctcat cttctttttc aaccttctgc tgttccggag tttcgatagc 3600 aacttgtttt tctgtatgat tttgctcttt accaacagaa gaaacagaag acgaaatttc 3660 ctttgatttg gaaaccacag atatttcttc ttcaattttt gattcgattt caattttcgg 3720 cggcgtagac atacaattat tttgctcatc actttcatca gttacagatt gatgtccagt 3780 tatgtcagaa acagttgtgt ggacggatgt agctggtgat acaagatgtt ccagctcatt 3840 atctttttca tcttctttaa gtggaatttc ttctgtaaaa ttctttttgg ctacttgcat 3900 agagtcatta catatccctt tagagaaggg ttgagaggcg gtcaagtcgt cgtcatcttc 3960 gtcttcatca gaaaaaattg gcttaacagg tttaaagact gctggctttg atttttttgg 4020 agatttattt tttcgccttg gagccgtaag taaaacgggc ttcgttggac tttgtggtgc 4080 acgggtgggt tgtgagtctt tctcctcaga ggtattagta taaagggaca ttgttaaagg 4140 acgtgcatta agattattct ttctactagg ggagaaattt aaagttttat gagattttgt 4200 tgaatctcgg gtgggagaaa cgggaagaat ggaattatcc tcggtcaagt cttcagggtc 4260 aatgttcgac gtagataaaa aagacagttt agtaggagat aagctatttg ggtctttcca 4320 tgtaaaaaac acacagtccg cacgacggcg tttgtgctcg gtgtaagggt catcatccgg 4380 ttcccaatca tgaagattaa tatcacaata taagcaatga gctgcatctt tagcatcagc 4440 agttggattg tatacaaaac cagaagcagc cattacactc ggctcacagt gataatcagg 4500 gcgattggta tacggccata ctttatcaac aaaagtttgt tctcgacatt ttgtgagagc 4560 tgcagcttgg gggttctggt ttggattgtt ttttgaggat aaaatatatg cccatggaca 4620 gctggggcta tgagtaatat gctctttcaa tggatcatca tcatcctccc agtcataaaa 4680 tgacttggta cacatatagc atgtaacatt atcaagtctt tcttcagaat tagattcaga 4740 gattggattg taatagaaac cgacagtagc aagctatttt cttgttagca acacagatga 4800 aaactctatc gtcaacatac agtttctggc gtcggtttgg ctcgcggcca tttttttttc 4860 tggaaagtgt caagtcgttt agagtaatta cacatttccc ttcgaaaccg attccatcgg 4920 cgtttagaag aagacgttat cggtttcatt ctgagcaagc ttcaacaagt gaaatttaga 4980 taccaaattt cgacttccga tccttaaaac tataaaatta atttttttaa aacttctggt 5040 tattgtcttt agacaatatc agatacttcc aaatgcatag gatagggaag gtcgcctcgc 5100 aaggcgtata tgggtaatgt ttactttttg tagattgcta gggcacacga gtttactgta 5160 attgaacaat gtcgttatat tgcgtaaaat gtcgttaagt agtatagcag actttaataa 5220 atggaaggtt cactggttac aaatttttcg agatgactag gtttagatat tatattgagt 5280 aaggaagatt caattattgt ctttaatgtc agccttatga tctttgttaa taaattcaaa 5340 atttaactag aagatttttg ctagcacaaa gtaatgtatc atagtttggt actaatattg 5400 ttacatataa taatattaaa gctccaactc taaagtatgg agcatcgtga aagaagaata 5460 aggctacatt ttcatggcta ttcaaaggaa actatgcata tcaacaagac aaatctgatt 5520 tcattttcct ctttcgatgc gatggtcaaa gttatgaata caatgatgaa tcagctgtct 5580 cattagaaaa aagttgaaaa gaggatgaca aatgcggtgg aaatattgaa cttcctaaaa 5640 cctcaaataa aagttaagca atagaggaag tacaatcatg aagacaatgt aaaataaatt 5700 aattgaatta gtcccatgtt gtttcaaagg tacaaaacct gtatctagta gtggagcagc 5760 caaaagctac aactaaatcg acaacaaaga ccaaaactgt tgaatgattc ctgtgtttcg 5820 tcaataaaac aaataataaa ctcacaaaat aaccacgatc tataaaccat tcgttggtta 5880 gaaagtgaat gaaaaaaagt aaacaaaagt tcgtttcgac acgcacactc aggacggact 5940 tgagaaataa tttaacaagt acaagatgtt caactttcca gcacaatcat taaacaacaa 6000 tataacaaaa tgagaagagt gacaactgcg gaatgtatgt ctaggtaaac ctcctaaaat 6060 gtaataatct cgtctaataa caatcgcgcc atacacgtaa aggtaaatga aaaaatcggc 6120 atcctcaatt gctcaatgaa ataatttaac gatattataa accacaggac cacagccaaa 6180 atcatgaagc cacttcgatg tttatgaaaa tgaacaatct aaaaaagaac gaaacctaaa 6240 caagcataaa tgaataatgt atgtgaagta tcattacata gccatatctt cggcattagt 6300 cgccgaaaat tgaaaatcgc cggcaggctc ttgtgtagtt ccaaatgtaa acgtatcacc 6360 gacggtttct ggttcaagct cttcgatttc gtcttcttca ccgaaaaact tttcgataat 6420 attgtaagct ttttggtaaa tttccgaatt agatgagttc tgacattcgt ggatcaaatc 6480 cataccacca gcatcctcaa cgtagacggc gtataaattg attttatcag ggttattcgc 6540 gcgatcaagt tcacccactc gcaaaatatt ttcaatacca tctaaagcaa cctggataat 6600 cttgttatct tgacaagcca gcaaattaca taaaggtttg attgcgcctt gctctacaag 6660 gtagcgaatt tggtcgggac gacgagcgcc accggatgtg gcattggaaa tggcccagca 6720 ggcttccttt tggattttaa agtcagcggt cgtaaggaga tgaattaaag gaggaataat 6780 gttagcttca ataacatatt gaatttgaga agaattaccg gccgttatat tactaattgt 6840 ccaacaggct tccttacgaa cgccatcgcg tggactgctt aacaaagaaa gtaaagcact 6900 taaagcacca caattaatga tgacctgggt ctgaacgtca tctcctgtaa caatatttcc 6960 tacggatcgg agagcaggag tctgtacttg agcgctagga tgcattaaaa gttcaacaag 7020 cctacgagga atccctgcat caatgatggc ttggatcttc tcattagcgc catcagataa 7080 ataggaaatg gcccaaaggg catcaactaa aacatcttcg tctaaggtat aaattaattt 7140 cgacagaaca gggataactt gcgaaatgct gttccaatcg ggttgtggat ttttgcctcg 7200 gcacatatta gacagggtcc aagtactatt gcggagcata ctaagacgcc tgttagattc 7260 gattatgtta agcaaaggct ccaaaactcc acattgcaaa acatgatcac gacacatggg 7320 tgaatcacca gcaatgttac ctaatgccca aactgcttgc tcgcgtacat cttgttcaga 7380 agaagataaa aggcttacaa aaacaggaac agcatttgct tctacaacca cgtgtgtttg 7440 attggaagat ccgctagcca cattagtgag agcccaagaa gcctcaaatt ttaataaatt 7500 gttctcatga gataaaaatt cgacgaagcg ggggacaacg cctgcatcaa taactttttg 7560 aattggtggg tttgtctcct tagacaaagc ctttcgaaac ttggcagtag cttgaatttg 7620 tgcctctatg tcatccgaat acaacgcctt caataaatca ggtaattgaa gctccaactc 7680 taaatcattt tccttatctt gttctaatgg aatagtttct tcggcaggct cttgaacatc 7740 aaccagatta cgacgcttgt tcaaattttc ctcacgtttt tgtttacgga tttcgatttg 7800 ctgggtttca cgtctgcggc gtaactcatc agcctgaaat gtacctttac ctttgtaatt 7860 ctgtcttctg tgttcaggaa taaagcgaga agatgcactc atgttcaatt cctttagtta 7920 ctcgttctct aaacgtatgg cgaaggatac gtctacactt ggctgatttc ctgtcatgga 7980 ccagttcatc aatcgttcgt aatgattata gcgaatactc cagataattc ataaaaaact 8040 attatatatc ttcttattaa aataaatctc ctttatgtat aaatattttt atatatgtat 8100 atatttcatt tttatactct tccatttaga gagctcgtga acattctctt aaaaatagtt 8160 aatgcttcca gtgtttattt cagtatatct ttgaagcttg cgggtatttg gcaattttgt 8220 gtagaaaaga aactaatata cagcttaaca gaattctcta gccataaaat acattttaaa 8280 gactgcaact cttctttatg tattcgcaaa gtgtctgcaa attgcatgtg taaacgaatt 8340 tggtaatgtc aacaactatg cttgttgtgt agcgctaaac acttccagtg aagaatgaaa 8400 tgatcttttt cttatctaaa aattaatttt gcactagatg atttcgtttc ttattccaaa 8460 aaaaataagc aatttgtttg ggcaatgtta aagcttttac tatactagat aacggcctgc 8520 atcctagtcg aggtcgcatt tacagagcac ggttaacttt tcaagaataa tcctttgaat 8580 aaattgaaat taaaaaacac catatacttc atcagccatc actcgttctg ctattattca 8640 ataaattgag attaattggt actccatgta gtgtatttta atgcgtaacg taatgtttat 8700 tagcagtgtt ggtgtagctc actatctaac aactagtgtt gcatagcttt caaagtatga 8760 taaacgaacc aaggcatcgt tattatagcg tatttggacg ctataaaaaa ttaaataagg 8820 aatagcgata actagtgtgt ggcatagtga cacgaagaaa acttaaagat ttaatgttct 8880 tttaccgaat tgtgattttg taccctattt atttgtgact gttttttggg taagaagagc 8940 gtaggaaatg agtgcgcgaa atcctgaaat ttacaagtta ccaccatgtc ggaacaagga 9000 gaccaaattg aacaagttga cgtcgtcgaa gaagttgaag ttgaggctgc cgctcctgaa 9060 actgtctccg ttgaggatgc tttgaaggaa gttttgaagc gtgcccttgt tcacgacggt 9120 cttgcccgtg gtattcgcga ggcttccaag gctcttgacc gccgtcaagc tcacctttgc 9180 gttctttgcg agtcctgtga ccaagaagct tatgttaaat tggttgaggc tctttgcgct 9240 gaatctgaga ctcctttgat caaggttgcc gaccccaagg ttttgggtga atgggctggc 9300 ctttgtgtcc ttgaccgtga cggtaatgcc cgtaaggttg ttggatgctc ttgtgttgct 9360 gttaccgtaa gtttaaattt agcctggcgc aggtgaaagg ctttgttcct tgttgatttt 9420 gcatatgatt aactaacatg taatttagga ctatggtgag gattccgctg ctcttcaaaa 9480 gcttttggaa agcttctctg cctaaactat ctagtggtaa acgaagcaat atgaaaggat 9540 ttaaaaaaaa tttattttct acttcagaat tcgtgtgtaa ataggttttt gtaaagtgaa 9600 gtcagagagt tgagtgtagt tttgagtagc acaaaataaa tcgaaagcat tctggctatt 9660 caacacctta taaaaggatg gttgtcgcct tattcctgtg tcagaaaaga aatcagtttt 9720 ttttctgaca ccttgcgtat tgatgataga gaaaaaagca tatattgttc aactgctgct 9780 aagacttgaa tattatgctt acttttttaa aatgataaaa aacgctaatg taaacaaact 9840 tacacttgag gcttataaaa aaaccatatc cattagcttt tgacaaagct ttttcttgtc 9900 cgatcacttc agcatgtatg aatttgatga gttgttcgat ttttgcattt gagctaatga 9960 aggatacaat gtaatttgaa attgaacggc caaccatttc ctcaatataa atcatcaaat 10020 ccaactagat aaacttgtgt tagtaactct aattctataa agtgaaacct acaagttttg 10080 gttagctagc agtcattaaa ggcagttttc acattttcca tttaccaatc tactcaattt 10140 ttaaaacgct gcgagagata ctgcatcaaa tgttatagtt catgtataaa tccttacttt 10200 gaatatttaa aattatcgtt aataaaaaaa cacgataaat gaaatactct cctcttcaag 10260 aaataatttg attattactc ctcgagtgtt ggatttaaga gcactgttcg tactaatagt 10320 catgggagta cctcgattgg gaaggttttt ggagccattt ggaaaaccag tatatttttc 10380 ttcataccca gaggtacctc taaattgcag tctcgttatc gatggacctt cttttgcttt 10440 ttggctttgg ttttcccaag gaatagtttg ctccgatttt caaggatatc agaaagcagt 10500 attggatttc caccacttgc ttagtaggtt gagattcaaa gaaatgtacg aataaatgaa 10560 gagtttttaa tttatacctc aattaattga agctcctctt gtggtttgca ttatggacta 10620 tcataatgac ctttttttga cttattcact ttctaacgca tacagagaat acatatttga 10680 tggtggactt cccttttcca aacaccaggt tagagtcaat agatatcagc aaaagattaa 10740 tgatctacgt tctgcttata taaatctttg tgtgccaatt gctcaacatg tgcttatggg 10800 acttgctaaa gccaaggtaa ttgtatgtaa cgaagaagca gataaatatt gtgcatttca 10860 agctaaaaag cttgatgctg ttattttaag tcaagactcg gatttcttgc tttatgatat 10920 agacacacca cactatggat acatcccctt gcagtcttta gatgttactt ccaacggcat 10980 tagtggaaga aaatacaggt ttgatgaaat acaaaaagat ttccatttcg atttgcatat 11040 tcttgctgcc tatttgggtg tagaagggca tcctctcgac ctagtaattg attatcacaa 11100 cacctttgag catatttgca aaatcttaga gaactctgta aaagataaat ttatcgaaaa 11160 gttagtttcc aaagaagaat tgactcgcgt tcacgcattc tactcgctta atgacctcaa 11220 gctagaaaca tctactataa atacattcat gtggggaaga gtccaggagc tcttaaattc 11280 acagctacag ccagcagaga tatggttacc tcagttattg gaattgccta gcaaacactg 11340 tagttggctt gaaagtgctc cacttcgtct tcaagcgtat gccaactttt ccaagcaaat 11400 gccagagttt ggaacagagg tattagaata ttttcgtttg agtgaccggt tatcgaagag 11460 attgatttct gtagattatg attatgctac agtctgcgaa acgttggata gcaaattttc 11520 taactggaat ttaccgcaca ggctagtact atggacttta cggtgtatga aaaatttaaa 11580 caatattaca gctaccagtt tcctcttaat gcatgtaagt ctattcttag gtagtcctat 11640 gaacttgcag ccggtggaac ctacgcaaga ggacattgcc agcgtttctc gttttatagc 11700 gacaatatat tcgatatgta tgttgatatt cagtgaagac aaggaacagt cttctattag 11760 ttttcaggaa tttgtttcat tcagccctct atcaagcact ttaaactttg ctttatttca 11820 ccaagcagca agtaagctga agacaggtaa aagcccacta agcattgtta cagataaaac 11880 tactgcctca ttaacctata aaatgtacaa agacctcacg aacgattact ctgatattta 11940 catgataatg gatatttgga aaccaaaaag gaaacgcaag actaaaaaag atcaatcata 12000 gatatacatt tttgtcacat gaattacaat caaacaaaat tttttgggaa acacgttata 12060 aaattaatga attaaattca aaacatatat cgaatacttt taaaccgtaa aaattaaaag 12120 aagcaattgg cttgcataaa cctttttttt caacctcatt ataatatgcg acaaactatt 12180 aacaaataca tatattctat cgattggaat atccgtttgg cattgaaaca ccgggtgggg 12240 catttaaatt agaggactcc gacgtattgt atgagcctgg tgcaccaggg ggagctgttg 12300 caccaggtat accaggcata gcaggaacag cgggatatcc aggaaatggt gcgggcatgc 12360 caggaggcaa agccattcca ggtggaacca tgggtggttg agacatattc aggttcggca 12420 taccaggcgc cccaggaatt ggtggcagag gcacaccagg aggagcgaat gtagtaggtg 12480 gaaggggagc agaagtacca gggatgaatg gcgcattttg tgaaggtact aaattagaag 12540 gctgtacagc ggactgttga gttggctgct gccaaggagg tagtgaactt ggattcatag 12600 aaagggcagg ggcagattgt ggagcagcag gttgctgcca aggggctgga tttgaagggg 12660 cggctgatga agctggtttg gcccaaggag caggactaga agtgctgcta gataccgaag 12720 tagacgcagc agcccaaggt ggagggtgac ctgcttgagg actagcagct ccactttcgg 12780 aaaattcaat agatttttgg ggttcaccat taccattgga aatagccgat cccccaccaa 12840 gctcttgcat aagactttga tattcccgat cagcagtaga atcagccatt ggaggttgtt 12900 gatctctaac aggacagtcg cgagcaatat ggccaatact tccgcaatgc ctacaaacaa 12960 tgttcattgt gtgattgata cgttcaggac aatcgaaacg acgatgaccc acgttaccgc 13020 aattttggca aacctgattt tcatcgtctc gtaaagtacc attaagagta gcaagctgac 13080 gaagttgatt tctttttaag tcgttttggc cttctggaac agaagcggcc gtttggataa 13140 cattatcaat tagttttatg gcatggttaa ttttatcttc agagtctgcg gtaacaaggc 13200 agtgtaaatc ttcttccata ttacctcgga cagatggatc gcttcttcct tttccttctt 13260 taacacttcc tttaccacga atagcaattt tggctccaga ttttgcttcc atatccttca 13320 aagtgtggcc acgaggaccg atcaggaggc cgatgaaatt aatctctgga taatccttaa 13380 cgggaacgta aaccttctct tgtgtttttg caggtcttct ataatcactg ggagcacgaa 13440 agcctggcac cattttcatt gcgcgctcaa taatccggtg acgctcatcc tctagctttt 13500 tcttgtaacg gatttctcga gtattcaatc ggcgaccatg gttatcgtat tgcggaggag 13560 gagaagggga ccgttcacgg tgatgaggaa caacatcacc ggttctaagc ttttgcgtaa 13620 tttcttccaa tcgaacattc aaagagtata attctaattg ctccatagtc atacaggatt 13680 taacggcagt ttccagctcc atttggcttg gtaacatttc ctcaatcggg gttggatgac 13740 cccaataatg ttttctataa gctcgacgac ctcgaccatc gtgatagcca tccggtctat 13800 gatccattct ggaattgctt ttataagaat cgcgataacc attactcatt ccatttgcat 13860 caggcaatgg tggtaaagaa tctggttttt cgtcaaaccg cctccttcct aagggagtat 13920 tattcgaacc taaaaatatt aataatttgc actaataatc tcttaaaaca cttaccagta 13980 gaccctactg accttgaatt cagcatttta ataagactgc tagatcgaag acgggcgttg 14040 gttcttggtg aaaagtaacg actgaaatgt aggaggcaag gaggcaataa agtaacggac 14100 gaaactgaag atacgacacg tttgagacaa acgagtgcaa taaccgtctc gctaaaaaag 14160 aattaaatgt ataattactt gaataaattt tcaaatgaga ctattcagtc aatgataagt 14220 tcaaccgaaa tttttttttt ctaacaatac agcaagcagt tcttgcactt gtttcgatat 14280 tcagttattg atcttaaatc ggtttagtgt atctctattc attgcgctaa ataaatctaa 14340 cgtactttat tataaacagc tttaagcatc attgcaattt ggatttacag aaacgagact 14400 ggcggattac ggcttagata tgatatggaa acattcatct ttcttaaaaa ataatcagac 14460 aatgatggag agttccacct ctgtttggta gggtaaagcg ttgattcttc tttttttttg 14520 cgattaaaac atactttaga gttcgctaaa taataattca agcatcaaag ttaagcgaat 14580 aggaattgta aaagagaata ttgtaatatt atattgtaat accagtatac aggcatatcc 14640 ttattttgta tcgaacaata gataggaggt ttttagaggg tgagtaatgc tcaagaataa 14700 gtcagtagaa aaatttttga tatttttctg aatttggttc ataattagat ggaagtgcaa 14760 actcttattg cccatgacca ttttgttgag cttgggttgg aattatagcg aaatccagca 14820 aggtttacat tgagaaacca gaatcgaaat taaaagaaat tggttttgga atgataaata 14880 gtacttatgt tttagttgat aatgagaaac atttttgtaa aacaggctgc gggcatacaa 14940 tctttttttc atattccaag cgacattcca ccactcggca tgcaagcctt ccttatctga 15000 tcagataatt tgcctagaga aaaatttact catgaagaaa aataaggatt cagtgtgttt 15060 agtgctttgt ttaaattcta ttaatttaat tctttactat caaactcaaa aatgcatgat 15120 accataacat cttaggaaca ttggaaagga tctgattttc attaagaaac gtttttgcca 15180 aatgttcata caactccaat atgacccgtt ttactgtgtg aaagaagcag agtcaggatc 15240 gtaatttttt cgtaaatgaa tcaagctgct tgcattttat caaaccacag aacctagtgt 15300 gaaagttcga atttggggaa taccgcactt caccatatgc tgaaaaaagt cgttaacaaa 15360 aattgattcc aaaagatgtc cggtacgctg agtgatcgaa acaaccggct cgttagaaag 15420 gcattccagt aactcgttag atctcttata aaaatttgat tcccaatttt tttacggctc 15480 gttccgtctg tttcatccat ttcccacatt cattcgcatt ttggtattga gccgttagtt 15540 gatataattc tggatttttc gtttggtaag acgctaatgc atctttaagt tttggttggg 15600 ttaatttaaa ctaattatct gaaatttata gttatcattc cattttttcg gtcgactgcg 15660 aaaatattta cttttgtcgt tttatagata gcttggattg tatttgttgg gaatcaattt 15720 agataaatat tttggatagt ctttggtgca ttgtcgaatt ttctcaattc tgttttggat 15780 ttccaatttt aacacagttc agcttcatcg atattcattc ttttttttcg gttcaatttt 15840 gcaaatacgc tacatattat cataataatg ccaatttcta gtcattctca tagtgggcag 15900 tatgtttgct tttaatttgt aaacaagcga tacatgttga tgtgtttgcc tgagatttta 15960 cagatgaatt ttttttttct tttattcagt gacaaaccac taacttttat tgaagatttt 16020 gtttgcatgc ccagggcaaa ctagaagatg taattcagga agccatacaa caaggttttc 16080 aatcgttttc atttacagaa cataccccta gagatcgagt tgaagactta tatcccg 16137 //