ID SPCC825 standard; DNA; FUN; 11689 BP. XX AC AL122011; XX SV AL122011.2 XX DT 15-OCT-1999 (Rel. 61, Created) DT 29-NOV-1999 (Rel. 61, Last updated, Version 2) XX DE S.pombe chromosome III cosmid c825. XX KW ABC transporter; protein kinase c substrate; PWI domain; KW ribosomal protein subunit s18; splicing factor; syntaxin. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-11689 RA Aert R., Volckaert G., McDougall R.C., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (14-OCT-1999) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk and Katholieke Universiteit Leuven, Laboratory of RL Gene Technology, Kardinaal Mercierlaan 92, B-3001 Leuven, Belgium XX DR GOA; Q9USH4; Q9USH4. DR GOA; Q9USH5; Q9USH5. DR GOA; Q9USH6; Q9USH6. DR GOA; Q9USH7; Q9USH7. DR GOA; Q9USH9; Q9USH9. DR SPTREMBL; Q9USH4; Q9USH4. DR SPTREMBL; Q9USH5; Q9USH5. DR SPTREMBL; Q9USH6; Q9USH6. DR SPTREMBL; Q9USH8; Q9USH8. DR SPTREMBL; Q9USH9; Q9USH9. DR SWISS-PROT; Q9USH7; PSY1_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c825 is overlapped by cosmid c895 at the 5' end, EMBL CC entry SPCC895, accessi on number AL035247 and by cosmid c1259 CC at the 3' end, EMBL entry SPCC1259, accession number AL034564. XX FH Key Location/Qualifiers FH FT source 1..11689 FT /chromosome="III" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c825" FT /map="IIIR" FT misc_feature 1..525 FT /note="nominal overlap with cosmid SPCC895, EM:AL035247 S. FT pombe chromosome 3" FT CDS 1180..3648 FT /db_xref="GOA:Q9USH9" FT /db_xref="SPTREMBL:Q9USH9" FT /label=SPCC825.01 FT /note="SPCC825.01, len:822, SIMILARITY:Homo sapiens, FT CAB43392, hypothetical 72.4 kd protein., (634 aa), fasta FT scores: opt: 1573, E():0, (41.5% identity in 633 aa)" FT /gene="SPCC825.01" FT /product="putative ABC transporter" FT /protein_id="CAB58409.1" FT /translation="MARGKRSTQRDADLELESLQSEIESESPQPVTKSKAKKNKKKLNK FT ASAFNSDNDSNYDLKPEDDEVDEEVVPVKKKPSKKSKKAKANAFEAFADEQSVEEEEEE FT DSEKPVRKNKKSSKKASPKNAFDALADDMDDLSLDEEESESSEKSKKKKKKSKSKDDGS FT EALDDGDIESSEKDKKKKKKSKENDDAPKKDRKTRKKEEKARKLASMLESENKDNDANA FT APLNKTDAFKDGLPSGRLIFAYASGQKVAPDGSNPADGITVTGNLLSPPNSRDLQVEKL FT SVSAWGKLLIKDSELNLINGRRYGLIAPNGSGKSTLLHAIACGLIPTPSSLDFYLLDRE FT YIPNELTCVEAVLDINEQERKHLEAMMEDLLDDPDKNAVELDTIQTRLTDLETENSDHR FT VYKILRGLQFTDEMIAKRTNELSGGWRMRIALARILFIKPTLMMLDEPTNHLDLEAVAW FT LEEYLTHEMEGHTLLITCHTQDTLNEVCTDIIHLYHQKLDYYSGNYDTFLKVRAERDVQ FT LAKKARQQEKDMAKLQNKLNMTGSEQQKKAKAKVKAMNKKLEKDKQSGKVLDEEIIQEK FT QLVIRFEDCGGGIPSPAIKFQDVSFNYPGGPTIFSKLNFGLDLKSRVALVGPNGAGKTT FT LIKLILEKVQPSTGSVVRHHGLRLALFNQHMGDQLDMRLSAVEWLRTKFGNKPEGEMRR FT IVGRYGLTGKSQVIPMGQLSDGQRRRVLFAFLGMTQPHILLLDEPTNALDIDTIDALAD FT ALNNFDGGVVFITHDFRLIDQVAEEIWIVQNGTVKEFDGEIRDYKMMLKQQIAKEREEE FT RRIELEKQKK" FT misc_feature 2080..2664 FT /note="Match to PF00005 ABC_tran, ABC transporter Score FT 102.84" FT misc_feature 3043..3534 FT /note="Match to PF00005 ABC_tran, ABC transporter Score FT 135.81" FT CDS join(4051..4150,4200..4283,4340..4378,4417..5073, FT 5201..5338,5391..5610,5655..5937) FT /db_xref="SPTREMBL:Q9USH8" FT /label=SPCC825.02 FT /note="SPCC825.02, len:506, SIMILARITY:Homo sapiens, FT G19P_HUMAN, protein kinase c substrate, 80 kd protein, FT heavy chain, (527 aa), fasta scores: opt: 481, E():1.3e-21, FT (30.5% identity in 502 aa)" FT /gene="SPCC825.02" FT /product="putative protein kinase C substrate" FT /protein_id="CAB58410.1" FT /translation="MKFSQWYTLTAPLLISSLYTVNAANDLRGVASDKSDLYKPDAKGN FT WKCLGSDKLISFNQVNDDYCDCPDGSDEPGTSACHNGKFFCKNTGYISSYIPSNRVDDT FT VCDCCDGSDESLIKCPNTCAQKAREYLATLEEHNRLVKNGLKIREQWALESAKKTDEVK FT ARYKEISDSLVAVSAEKTQLSEKVEKMKRSTDLGAEAVLPLDFQDLRVALLSLVDERNE FT MQERLDILTNLLDELTLLYETDKFDETMKEAILSFEDLKEQEIRRKVSSDDVHNYLESC FT NNHLSMLTGPSEDITFSSLIKDIKKILNSLVWNIKLSLINFGILSPSASSTPLTDSESY FT RRFEAAQRDLDAAEENEKSLEKEHTKLMHELEYHHGWDLYRAIKGMETKREIGGYTYKV FT VFYENVFQDSILLGNFASQEGNVLKYENGQSCWNGPHRSAIVTVECGVENEIVSVLEAQ FT KCEYLIKMKSPAACSPDQLKQSLLNTQNSANENAVNGMEDKESSVDEL" FT misc_feature 4151..4156 FT /note="gtaagt, splice donor sequence" FT intron 4151..4199 FT /note="confirmed intron" FT misc_feature 4284..4289 FT /note="gtagga, splice donor sequence" FT intron 4284..4339 FT /note="confirmed intron" FT misc_feature 4326..4339 FT /note="ctaacacattttag, splice branch and acceptor" FT misc_feature 4379..4384 FT /note="gtaata, splice donor sequence" FT intron 4379..4416 FT /note="confirmed intron" FT misc_feature 4404..4416 FT /note="ctaatccacttag, splice branch and acceptor" FT misc_feature 5074..5079 FT /note="gtatgg, splice donor sequence" FT intron 5116..5200 FT /note="intron confirmed from EST" FT misc_feature 5184..5200 FT /note="ctgactttgagaattag, splice branch and acceptor" FT misc_feature 5339..5344 FT /note="gtatgt, splice donor sequence" FT intron 5339..5390 FT /note="Intron confirmed by est" FT misc_feature 5378..5390 FT /note="ctaattcattaag, splice branch and acceptor" FT misc_feature 5611..5616 FT /note="gtaggt, splice donor sequence" FT intron 5611..5654 FT /note="intron confirmed from EST" FT misc_feature 5642..5654 FT /note="ctaacaactctag, splice branch and acceptor" FT CDS complement(6791..7645) FT /db_xref="GOA:Q9USH7" FT /db_xref="SWISS-PROT:Q9USH7" FT /label=SPCC825.03c FT /note="SPCC825.03c, len:284, SIMILARITY:Saccharomyces FT cerevisiae, SSO2_YEAST, sso2 protein., (295 aa), fasta FT scores: opt: 549, E():7.7e-26, (34.1% identity in 258 aa)" FT /gene="SPCC825.03c" FT /product="putative syntaxin" FT /protein_id="CAB58411.1" FT /translation="MNKANDYTLGVEMIPLSMGEFFEEIDHIRDAIRQIEDNVGRIEML FT HQQSLQEIDEANIAATTRHLEGYTSDTRRLQTSVQLAIRSLESQNMQLPPDNDTATRKT FT QTEAVKKKFMDQIRHFLQIEKTYRAQYEQRMRRQLEIANPRATEDDFQTAINEENGGQV FT FAQALLRSNRSGEARTALREVQERHADIKRIERTIAELAQLFQDMATMVQEQEPMVDKI FT VTDAVNVRTNMGEGTQHMDRAIKSARAARKKKWICFGICVVIICVIVAVLCGVLIPVLG FT NRH" FT misc_feature complement(6836..7648) FT /note="Match to PF00804 Syntaxin, Syntaxin Score 215.51" FT CDS complement(8755..9369) FT /db_xref="GOA:Q9USH6" FT /db_xref="SPTREMBL:Q9USH6" FT /label=SPCC825.04c FT /note="SPCC825.04c, len:204, LOW SIMILARITY:Bacillus FT subtilis., PAIA_BACSU, protease synthase and sporulation FT negative regulatory protein pai 1., (171 aa), fasta scores: FT opt: 133, E():0.0053, (30.8% identity in 117 aa)" FT /gene="SPCC825.04c" FT /product="hypothetical protein" FT /protein_id="CAB58412.1" FT /translation="MHFLKQYLFYSPRRMKTQEIKNVTLEDVDFLKNLGVWVEIYHHLE FT KGLLQQCFNLVKKNMEALYRQSSFGWDDSEKLKEMEMEKLEYICIFEKTSKKLVGFLSF FT EDTVEAGLTCLYIYEIQLDEHIRGRNVGKWLLKNASILAYRRNLKYIFLTVFSANLNAL FT NFYHHFDFVPHESSPQEKKFRSGKVIHPDYYILYTKSRKDW" FT CDS join(complement(10971..10988),complement(10828..10917), FT complement(10439..10768),complement(9933..10400)) FT /db_xref="GOA:Q9USH5" FT /db_xref="SPTREMBL:Q9USH5" FT /label=SPCC825.05c FT /note="SPCC825.05c, len:301, SIMILARITY:Plasmodium FT falciparum., O77355, mal3p4.20 protein., (558 aa), fasta FT scores: opt: 380, E():1.2e-16, (26.6% identity in 312 aa)" FT /gene="SPCC825.05c" FT /product="putative splicing factor" FT /protein_id="CAB58413.1" FT /translation="MSGFYKGVAAEQETLFTTADKKLMRSTKFPASYDTKVDMKKVNIE FT VLKPWIATRLNELIGFEDEVVINFVYGMLEEAVEASKTSDSQNESTLDPRKVQLNLTGF FT LESNATAFTEELWSLIISASQNQYGIPEKFILEKKEEISKLKDRTEASKEESKTVTDHS FT NRRESRRESTYYDSRERNGKRTSRSTLDRKRFHDASDTERNRYGRSPSPHSRFSEKPRG FT ERYDIRSYSRSHKERYEDRYRPTRRRERHYRTRDDEGFDEFGRSRDGRWRESRTSYREK FT HRYDRDALSSESDSGTQKHD" FT misc_feature complement(10401..10414) FT /note="ctgacatttaacag, splice branch and acceptor" FT misc_feature complement(10433..10438) FT /note="gtatga, splice donor sequence" FT misc_feature complement(10602..10859) FT /note="Pfam match to entry PF01480 PWI, PWI domain," FT misc_feature complement(10769..10781) FT /note="ttaatttatttag, splice branch and acceptor" FT misc_feature complement(10822..10827) FT /note="gtacaa, splice donor sequence" FT misc_feature complement(10918..10930) FT /note="ctaacattaaaag, splice branch and acceptor" FT misc_feature complement(10965..10970) FT /note="gtatgt, splice donor sequence" FT misc_feature 11252..11687 FT /note="nominal overlap with cosmid SPCC1259, EM: AL034564 FT S. pombe chromosome 3" FT CDS complement(11438..11689) FT /codon_start=1 FT /db_xref="GOA:Q9USH4" FT /db_xref="SPTREMBL:Q9USH4" FT /label=rps18-2 FT /note="SPCC825.06c, len:83" FT /partial FT /gene="SPCC1259.01c" FT /gene="SPCC825.06c" FT /product="ribosomal protein subunit s18" FT /gene="rps18-2" FT /protein_id="CAB58414.1" FT /translation="IIQNPSQFKIPSWFLNRQKDINDGKSFQLLANNVDSKLREDLERL FT KKIQTHRGLRHALDLRVRGQHTKTTGRRGKTVGVSKKK" FT misc_feature complement(11471..11686) FT /note="Match to PF00416 Ribosomal_S13, Ribosomal protein FT S13 Score 140.98" XX SQ Sequence 11689 BP; 3843 A; 2061 C; 2170 G; 3615 T; 0 other; tattgtgaag cgttgaaagc gtttattgat tatatttctt ttaggatgtt tttgctattg 60 atttaaacat cccccgtacg tgtactacag ctgtcaacat tggtaataag tacgcagttg 120 gacatacgcg tataagagca tttagaaatt tttttgatca ggattacctt tttcttttgc 180 aattttaaca aatcatggcg caaacaggaa tagtaagaag cattctcaac gtcacttttg 240 agaatatgga attcaattcg caaagtttca agacaaaata ccggttatat aaatccacag 300 cgtttaaaga atgatcgatc attgagacgt atgagtgttt cagatgatga tgagtttcct 360 gtcttcgagc aaatccttaa agagacctta ctttttctgg ctcacttata aacagactta 420 catcttcgtt tgaattgaat aatattcatt agcactagca aaggttcata atttatggag 480 caatgttgac ctggggattt tgacaattcg ctaaattctc cacaggatca aaggattaaa 540 gcgtttactt caaatctgta ctgtataaac tggggaaata tccgtgcaag cgtcttaagg 600 gctgaaaatt taagaggtat tttttaccat atatggttga ctagtctccc aactagatcc 660 taattactat aatttccctt taagtttata aaataaaaag ctaaaaatcc tttacaaatt 720 tcttccagcg tatcattcag gttttctcgc tacctaataa actatgtaat aatgtaagag 780 atttcctagg tttttttgcg aatattgcct gagactacac ttttatggta aatagcaaag 840 aatccttata aacatgcttc ttattgttta atttttctta attcaacctc ttaggttcag 900 acttaaattg cctcctgttg gccctaacac ttgcacatat atattaattt ttcactatgc 960 catttgacct ctacagctaa ctgcaaaagt cgcttgtcca tttaaaattg ggtaaataat 1020 cggtcaattc ttttaaaaaa aaattttaaa taaagagaat aattgtaata actctttcaa 1080 ggattatttt acttttgaaa ttacattttt tgctggttgc gcactttttc tgcatcattt 1140 attgaagact catctaatct taacaagaat aatttgataa tggctagggg aaagcgttca 1200 actcaacgtg atgctgattt ggagcttgaa agcttacaaa gtgagattga gagtgaaagc 1260 cctcaacctg taactaaatc caaagcaaag aagaacaaaa agaaactgaa taaagcaagt 1320 gctttcaata gtgataacga ctccaattat gatctgaagc cggaagacga tgaagtagat 1380 gaggaagttg ttcctgtgaa aaaaaagcct tctaaaaaat ctaaaaaggc caaggctaat 1440 gcttttgaag cttttgctga tgaacaaagc gttgaagaag aggaagaaga ggactccgaa 1500 aagccagttc gcaagaataa aaaatctagc aaaaaggcta gtcctaagaa tgcatttgat 1560 gcacttgctg acgacatgga cgatctctct ctagatgagg aagagagtga gtcatctgaa 1620 aaatcaaaga agaagaaaaa gaagtcaaaa tctaaggatg atgggagtga agctttggat 1680 gatggagata ttgaatcatc tgaaaaggat aagaaaaaga aaaagaaatc taaagagaac 1740 gatgatgctc ctaaaaaaga tagaaagact cgcaaaaaag aggaaaaggc tcgtaaactc 1800 gctagtatgt tggaaagcga aaacaaggac aacgacgcaa atgctgctcc tttgaataaa 1860 accgacgcgt ttaaagatgg tcttccaagt ggccgcctta tttttgcata cgcttctggt 1920 caaaaagtcg cccctgatgg tagtaaccct gcagatggta ttacagtcac cgggaactta 1980 ttaagtcctc caaatagtcg tgacctacag gttgaaaaac tttccgtttc tgcatgggga 2040 aagcttctaa ttaaagattc agagttgaat ttaattaatg gtcgccgtta cggcttaatt 2100 gcgccgaatg gtagtggtaa gtccacgtta cttcatgcaa ttgcttgtgg cttgatccct 2160 actccttcct ctttggactt ttatttattg gaccgtgaat atattcccaa cgaacttact 2220 tgcgttgaag cagttttgga tatcaatgaa caagagcgta aacatttgga agcaatgatg 2280 gaggacttgc ttgatgatcc tgataaaaat gctgtagaat tagatactat tcaaacacgc 2340 ttaacggacc ttgaaacaga gaatagtgat catcgtgtat ataaaattct ccgtggtctt 2400 caattcactg acgaaatgat tgccaaacgc accaacgaac taagtggtgg ttggagaatg 2460 cgtattgcct tggctcgtat tttgtttatt aagcccactc tgatgatgct tgatgaacct 2520 acaaaccact tggacttgga agctgttgca tggttagaag aatatttaac acatgagatg 2580 gagggacata ctttacttat cacatgtcat actcaagaca cacttaatga agtttgtact 2640 gatattatcc atctttatca tcaaaaactc gattactact caggcaatta cgatacattc 2700 cttaaagtac gtgctgaacg cgatgttcag ctcgctaaga aagcccgtca acaagaaaag 2760 gatatggcta aacttcagaa caaattgaac atgaccggta gtgagcaaca aaagaaggct 2820 aaggcgaagg taaaggccat gaacaaaaag ttagaaaagg ataaacaatc tggcaaagtt 2880 ttggatgaag aaatcattca agaaaagcaa ctggtgatac ggtttgaaga ttgcggtggg 2940 ggtatacctt cccctgctat caaattccaa gacgtttcct tcaattatcc aggtggtcca 3000 acgattttct ctaaactaaa ttttggcctg gatttgaaat caagagttgc cttggtaggt 3060 cccaatggtg ctggaaagac tacgttaatt aaattaatct tggaaaaggt tcaaccaagt 3120 actggtagcg ttgtacgcca tcatggtttg cgtttagccc ttttcaacca acacatgggt 3180 gatcaacttg atatgcgact ttctgcagtc gaatggttgc gtacaaaatt tggcaataaa 3240 cctgaaggag agatgcgcag aatcgttggt cgttacggat taacgggcaa aagccaagtc 3300 attcctatgg gtcaattatc tgatggacaa cgtcgtcgcg tactttttgc ttttcttgga 3360 atgacacaac cccatatctt attgctcgac gaacctacta atgccctgga cattgacact 3420 atcgatgccc ttgctgatgc tctgaacaac ttcgatggtg gtgtcgtttt cattactcac 3480 gacttccgtt taattgatca agttgctgag gaaatctgga tagtacaaaa cggtacagtg 3540 aaagaatttg atggagaaat tcgtgattat aaaatgatgc tgaaacaaca aattgctaag 3600 gaaagagaag aagagcgtcg aattgaattg gagaagcaaa aaaaatagga agtgtcgtgt 3660 ttgggttggt atagataaat ttaaaattgc ttcattgtac atttacggca tccccgtcat 3720 ctctatattg ttgcttttca aaaacttttt ttttaaatag tttttttgaa gagtttaggt 3780 ctccgtaatt gatttgtttt ttttttaatt acattgttta agttgaaaaa ttctgtaata 3840 gttaagcaat aaatagtagt atttttacaa aaaccctaat accataaaac caccataact 3900 catgatctga ttaaaatctt aacaatttaa atatcagacg aacaattagt gcaatttttt 3960 acttttgatc cttctatccc tgaattccta tatgtggtcg tgaaccggtg tgatctgaag 4020 ctacaaccaa cactaaaaaa ttctgagaag atgaagttca gtcaatggta cacgttgact 4080 gcacctttgt tgatcagttc attgtataca gtaaatgctg caaatgacct ccgtggtgta 4140 gcaagtgata gtaagtttga attgagatta caatagaaag cattactcat tacttgtaga 4200 atcggacttg tacaagccag atgccaaagg aaactggaaa tgcttgggaa gtgataagtt 4260 aatatcattt aatcaagtca atggtaggat tattgagaat taaaatctga agtgccaatc 4320 taaacctaac acattttaga cgattattgt gattgccctg acgggtcaga tgaaccaggt 4380 aataagcttt tactatttat ttgctaatcc acttaggtac atctgcttgt cacaatggta 4440 aatttttttg taaaaataca ggatacatca gttcatatat cccatcaaat cgtgttgacg 4500 ataccgtgtg tgattgctgt gacggttctg atgaaagtct tattaaatgc cctaatactt 4560 gtgcccaaaa ggctcgagaa tacttggcaa cattagaaga gcataataga cttgtaaaaa 4620 atggactaaa aattcgcgaa caatgggctt tagaaagcgc aaaaaaaaca gacgaagtaa 4680 aggctcgata caaagaaatt agcgatagtt tagttgccgt ttccgctgag aaaacccaat 4740 tatctgagaa ggtggagaag atgaagcgtt caacggattt aggtgctgaa gccgtgttgc 4800 ccttagattt tcaagatttg agggtagcgc tactttcact tgtcgatgag cgtaatgaaa 4860 tgcaagaaag acttgatatt ttgactaatc ttctcgatga actaacactt ctatatgaaa 4920 cggataaatt tgatgaaact atgaaagaag caatactttc ttttgaagat cttaaagagc 4980 aagaaatcag aagaaaggtg agctccgatg atgttcataa ctatctcgag tcatgtaaca 5040 accacctttc aatgctaaca gggccttctg aaggtatggg aaacataatt attgtattat 5100 ttagtcacag aaaaagtaga aaatttgatt ttttcctttt tctttttatt atttagctgc 5160 gtggtcaaat gtttcaactt taactgactt tgagaattag atattacttt ttcttctttg 5220 atcaaggaca tcaaaaaaat tttaaattca ctcgtttgga acatcaaact ctcacttatc 5280 aattttggaa tattaagtcc atctgcctcc tcaactcctt tgactgacag tgaatcatgt 5340 atgttatttt cgttgattgt tagttgatta ccaattacta attcattaag atcgccgttt 5400 tgaagcagct caacgtgacc tagatgctgc tgaagaaaac gaaaagagtc ttgaaaagga 5460 acacacaaaa cttatgcatg aattggaata ccaccatggg tgggatttgt acagagctat 5520 caagggaatg gaaacaaaac gtgaaattgg tggctataca tacaaggtgg tgttttacga 5580 aaatgttttt caagattcca ttctattagg gtaggtgtag atttgctttg gtatgtgttt 5640 gctaacaact ctagaaattt tgcctcgcag gaaggaaatg ttctaaagta tgaaaatggt 5700 caaagttgct ggaatggtcc tcatagatct gccattgtta ctgttgaatg tggagtagaa 5760 aatgagattg ttagtgtact ggaggctcag aaatgtgagt atttaatcaa aatgaagagc 5820 cctgctgcgt gctcccctga tcaactcaag cagtctttac tcaacaccca aaacagcgca 5880 aacgaaaatg ctgttaatgg aatggaagac aaggaatcat ctgtcgatga gttataatat 5940 aatatcgctt atgccattta aataaattac tacattcaac tcatggtcgt ctctacagta 6000 aattacgcct atttttttta agcattttga aaatatacaa caacgtttat tgaaatatcc 6060 agaactgatg atgaacttcg attccgttca tatacgtata aacacataaa ctgttaaaac 6120 aatgctgtta tcgtctttta aaaaaccaaa taaattttgt tggtttctac caatataaaa 6180 cccgagaatg atgtaaaaca ctgctggggt aaagaacgaa gcagcatgcc atgaataaac 6240 aaaataacaa tgccagacgt gtagtccaaa tattttacac tgcaacttaa gtaacgagcg 6300 atgagtgaaa atgaaaagac tttccagagt ccataaatca caatcggacc gttcaaacgg 6360 gaaatatgct aaaaaggtaa acgtttcaaa ggtgatatct aaccggccat atcactgcag 6420 catttgaaaa taaatacatt tgcagcaact caaatattaa gtaagggtag atggggaaac 6480 ggaaaggtgt agacagggat tgtaataacg atcgcagaga attttgcaag agatggatga 6540 aaggaaatga aaatgaataa gaataacgtg gataaagggt gaaaaaggta aaattgtaca 6600 aactatacaa gtccaaggaa gaaaggttta aaagaaaaga aacagaaaaa aaaggggtaa 6660 gcaaaaggat tatggttaga acagtcaaga tactagaaga ataaaagaat atcattaaaa 6720 ccaagtaatg aaaaacatga ttttttaaaa gaaaaaaact tttcatgcaa caaggaagaa 6780 tgaccgttga tcaatgtcta ttgccaagaa caggaatcaa aacaccacat aaaacagcaa 6840 cgattacaca aatgataaca acacaaatac caaagcaaat ccactttttc ttacgagctg 6900 ctctagcgct cttgatagct ctatccatat gctgagttcc ttcacccata ttcgtgcgaa 6960 cgttaacagc atccgttaca attttatcca ccattggttc ttgctcctgt accatagtag 7020 ccatatcctg gaaaagctgt gcaagttcag caatggttct ttcaattctt ttaatatcgg 7080 catgacgctc ctggacttcc cgtaatgcag tgcgagcttc accagaccga tttgatcgaa 7140 gcaaagcctg agcaaatact tgtccaccat tttcttcatt tatagcggtt tgaaaatcat 7200 cttcagtagc cctggggttg gcaatttcaa gctgccgacg catacgttgt tcatattgag 7260 cacgatatgt cttttctatt tgtaaaaagt gacgaatttg gtccataaat ttctttttta 7320 cagcttcggt ctgtgttttt ctggtggctg tgtcattatc gggtggcagc tgcatatttt 7380 gagactctaa tgaccggatg gccaactgaa cgctagtttg gagacgtcga gtatctgatg 7440 tgtaaccttc taaatggcga gtcgtagctg caatatttgc ttcgtcaatt tcttgcagcg 7500 attgttgatg caacatctca attcgaccga cattatcttc gatttgacga atggcatcgc 7560 gaatatgatc gatctcttca aaaaactctc ccatactaag agggatcatc tccactccta 7620 gtgtataatc gtttgcttta ttcattttgt tatatttatc tgtttaaacc cgttttgttg 7680 aacaaacaag gtatagatac cttctgttgt tgttggttaa agacaagaac gtttttccta 7740 ctaaaaataa agaatcatac agcagcattt aacgaatgtt ttcgcagaca atggtaaaca 7800 aaaggcggct tagcaacaac acactgttga aagtccgcca atcataatca aatccgagct 7860 ttgtgtgacg tagcagtgtt tactttttaa tgttgtacaa tacaatccgt taaacttgat 7920 atcaaaaata tacgcctaat acttaaaaat tgaattccaa ggaagttgga gtttgttaaa 7980 atcacaatag gatactctcc tcgttatttg gacttgtatg aggtacgaat aaggagtgaa 8040 gttttcttga tattctggtt gaaaagaaag atttttgctg tagtttattt caagaaatgc 8100 ataaaaaata tttaattgtt tttcgtagtt gatggagttg actgtctcgg aattaatcgt 8160 tcttttttgt ttttgttttt taacactaaa agcaatcatg gtttgaatgc cattggaaac 8220 gagaaaggaa tgctgaaaat tttagttatc attgtcggta atttttctct gatctatact 8280 tctaggtttg aatttgaaac agaagtaatc gatatcctaa gtgattttct ttgagtaatt 8340 aaaaagatag taactatata cctcaatata ggtagaaata ttttgacatt aatgaataaa 8400 ttaaaataga aattgtagcc cctccaatcc ctaagctgtt atggttgaaa agcaattcgc 8460 atcatgtaac attacaacgt tgctaatgga ataaaacaaa agtcctgaac agaaatttca 8520 aatattttac taaagtttta aaggtttagt aaatggaaca atattttgat gggaccaggt 8580 cataatgtat ggtatcgtag atttaaaaaa tacacaaaat ttgatgactt caatgcaaaa 8640 cattaaactc agagattgga tgcaccaaag aagaaaagag actatacaca tattttgtag 8700 ttttagaggg ggatggcaaa aaggtatgaa gcatgtgtgt atacggaagc tcaattacca 8760 atcctttctg gacttcgtat aaagtatata atagtccgga tgaattactt ttcctgatct 8820 aaattttttc tcttggggag atgactcatg aggtacaaaa tcaaaatgat gatagaaatt 8880 caaggcgttt aaattggcgc taaatactgt caggaaaata tattttaggt ttcgtcgata 8940 tgcaagtata cttgcatttt ttaataacca tttcccaacg ttcctccctc gtatatgctc 9000 atctagctgt atctcatata tgtataaaca agtcagacct gcttccacag tgtcttcaaa 9060 actcagaaat cctaccaatt ttttcgaggt tttttcaaaa atacaaatat actctaattt 9120 ttccatctcc atttccttca atttctctga atcatcccat ccgaaggagc tttgtcgata 9180 tagtgcttcc atgttctttt ttaccaaatt gaaacattgc tgaagaagtc ctttttctag 9240 atgatgatat atctccaccc aaacccctaa gttttttaaa aaatcaacgt cttcgagtgt 9300 aacattcttg atttcctggg tcttcatacg tctgggtgag taaaagaggt attgcttcaa 9360 aaaatgcata atgttgttaa ggtatcaata tcacattaca cttttaaaaa ccaaagattg 9420 aataagggtt taatacatat cgagcaaaat gctatcattt ttattattgt tgctacagca 9480 agcctactta gtaatacacg ataacaaaaa atgaatattc ttaatcatct aataattcct 9540 atttccaata atcgttttaa gccgtatcct ttattcaaat aacagcagtt gtattaattt 9600 agagcttgac ttctgatgaa accggaagag accttaaacg caatatgcaa ctttaaaata 9660 tatatatagt ttccaaagat agaaagaaac ttgcaaacaa aaaaaaactt ttacaaacaa 9720 tttcggggtc attaacgcgt atatttcaat tagcatgatt taacttcaag gcattttagc 9780 agatagatga tgctctaaag gcatatttgc taaacccact gcttgtggat aaaaatttgc 9840 tacaacttgt aattagcaga gcagtaaaag tttttttcat cgttatcaag tttaggtatc 9900 ctccaacttg acaccagcct tcataaattt cattaatcat gtttctgcgt tcctgagtcg 9960 ctttcagagg agagtgcatc ccggtcatat cggtgctttt ctctgtaact agttcgagat 10020 tccctccatc ttccatctcg agatcttccg aactcatcaa atccttcatc atctcgtgtt 10080 ctataatgtc gttcccgacg tcgagttggt ctatatcgat cttcatacct ttctttatga 10140 gagcgtgaat aagagcgaat atcgtacctc tcacctcttg gcttttctga gaaccgagaa 10200 tgaggcgacg ggcttcgacc atatctgtta cgttcagtgt cacttgcatc atgaaacctt 10260 ttacggtcta aagtagaccg tgatgttctt ttcccatttc tttctcttga gtcataataa 10320 gttgactcgc gccttgattc tctacgattt gaatgatcag tcacagtctt cgattcttct 10380 tttgaagcct cagttcgatc ctgttaaatg tcagtaagtt ttgggaaaaa gatcatactt 10440 ttagttttga tatttcttcc tttttctcca aaataaattt ttccggaatt ccatactggt 10500 tttgcgaggc agagataatt aacgaccaaa gctcttcggt gaaggccgtg gcattgcttt 10560 ccaaaaatcc cgttaaattc aattgaacct ttctaggatc aagtgttgat tcattttggg 10620 aatcacttgt ttttgaggct tcgactgctt cttccagcat gccgtacaca aaatttataa 10680 caacctcgtc ctcaaaccca attagttcgt tcaatcgagt cgcaatccaa ggtttaagga 10740 cttcaatatt cacttttttc atgtcaacct aaataaatta atgtcttgaa cgtaacagcg 10800 cctgaaagaa tgcagcaaat cttgtacctt agtatcataa ctagcaggaa actttgtact 10860 tcgcatcaac ttcttgtctg cagtcgtaaa tagggtttcc tgctcggcgg caacaccctt 10920 ttaatgttag ctttggttaa aatgacacat tctttactca aactacatac cttataaaac 10980 ccactcattt tgaccaagaa tgaaagaagg cagcaataaa cagtcaaata ttaagaaatc 11040 gtcgtcaacg tattttctca cctccctaag gttagaatat cttcctctat taaataatgg 11100 tgctaagcgg cggttaagtg caggtgtatt atatgctttt taaatcttac aaaagcttag 11160 tgctcagcta gtgcttcaac agatatttcc acacaataca atcgtagaat ttagacatag 11220 ttgatgcagt catttacatt tcaactaagc agatcatggt ataaaaaaag ttcggtactt 11280 gaaattctag caaaccgctg ctgcaaatac actatcacat ggtctacaat atatctacac 11340 ggattaaaaa attttcaact acacaaatga aaaatcagta tgtacgacaa tcgtcaaaac 11400 cagtatttag ctacacaaaa gacaatgaat tttatgatta cttcttcttg gagacaccga 11460 cggtcttacc gcgacgtcca gtagtcttag tgtgctgacc acgaacacgg aggtcaagag 11520 cgtgacgaag accacggtga gtttgaatct tcttgagacg ctcaagatcc tcacgaagct 11580 tgctgtcaac gttgttggca agcaattgga aggacttgcc atcgtttata tccttttgac 11640 ggttaaggaa ccaggaagga atcttgaatt gagaagggtt ttgaataat 11689 //