ID SPCC5E4 standard; DNA; FUN; 23000 BP. XX AC AL033406; XX SV AL033406.1 XX DT 09-NOV-1998 (Rel. 57, Created) DT 02-FEB-2000 (Rel. 62, Last updated, Version 3) XX DE S.pombe chromosome III cosmid c5E4. XX KW 60s ribosomal protein L27a.2/L28A; abhydrolase domain; KW alcohol dehydrogenase repressor protein; cut1; cut1 protein; KW dna repair protein rad18; G-beta repeat; Leucine Rich Repeat protein; KW protein transport protein; rad18; rpl27a; rpl28-1; taf72; KW tfiid subunit taf72p; WD domain. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-23000 RA Wood V., Rajandream M.A., Barrell B.G., Rieger M; RT ; RL Submitted (09-NOV-1998) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk and Biotechnologische und molekularbiologische RL Forschung, Angelhofweg 39, D-69259 Wilhelmsfeld, Germany XX DR GOA; O13282; O13282. DR GOA; O74446; O74446. DR GOA; O74873; O74873. DR GOA; O94305; O94305. DR GOA; P18296; P18296. DR GOA; P36585; P36585. DR GOA; P53692; P53692. DR SPTREMBL; O74446; O74446. DR SPTREMBL; O74873; O74873. DR SPTREMBL; O74874; O74874. DR SPTREMBL; O94305; O94305. DR SPTREMBL; O94306; O94306. DR SPTREMBL; Q9P7Z6; Q9P7Z6. DR SWISS-PROT; O13282; T2D4_SCHPO. DR SWISS-PROT; P18296; CUT1_SCHPO. DR SWISS-PROT; P36585; R28A_SCHPO. DR SWISS-PROT; P53692; RA18_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c5E4 is overlapped at its 5' end by cosmid SPCC31H12, CC EM:AL031824 and at its 3' end by cosmid SPCC16C4, EM:AL031535. XX FH Key Location/Qualifiers FH FT source 1..23000 FT /chromosome="III" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c5E4" FT /map="IIIL" FT CDS 1..193 FT /codon_start=2 FT /db_xref="GOA:O74873" FT /db_xref="SPTREMBL:O74873" FT /label=SPCC5E4.01 FT /note="SPCC5E4.01, len:63, SIMILARITY:Schizosaccharomyces FT pombe, O94672, protein transport protein sec23 homolog., FT (765 aa), fasta scores: opt: 262, E():3.6e-14, (62.9% FT identity in 62 aa)" FT /partial FT /gene="SPCC5E4.01" FT /gene="SPCC31H12.07" FT /product="protein transport protein sec23 homolog" FT /protein_id="CAA21956.1" FT /translation="IPRFIVCDQGGSQARFLLSRLNPSETHNTTSMYGAPPAHAILTDD FT VSLQTFMSHLKKLAVAVS" FT misc_feature 1..3571 FT /note="nominal overlap with cosmid SPCC31H12, EM:AL031824 FT S. pombe chromosome 3" FT CDS complement(893..2965) FT /db_xref="SPTREMBL:O74874" FT /note="SPCC5E4.02c, len:690, SIMILARITY:Saccharomyces FT cerevisiae, CCR4_YEAST, glucose-repressible alcohol FT dehydrogenase transcriptional effector (carbon catabolite FT repressor protein 4), (837 aa), fasta scores: opt: 944, FT E():0, (36.5% identity in 589 aa)" FT /gene="SPCC5E4.02c" FT /gene="SPCC31H12.08c" FT /product="similar to yeast glucose-repressible alcohol FT dehydrogenase transcriptional effector (carbon catabolite FT repressor protein 4)" FT /protein_id="CAA21957.1" FT /translation="MFNPRYTQGTIYPGAHPGLLTPDHQHAAILSVQNSPALENSNISE FT HWKQQIALATQSRSFSSPHQRAHNAAALARSGGPGFSMNYNARTGAFTGGPNAAGLSSL FT GGKYNTSSTTTTLTTSTTLNTSSGTTLNSTSKTTTSSVAVDDQKSKSDSKKERRDWTCL FT DLGGIGLRNVSTDLFKFSFLTELYINHNNLTRLPPEIGKLKNLVILDASGNSIKTIPPE FT LGLLTELREVLLFDNMISVIPAELGTLFQLKILGIEGNPLQDVYKNQIMESGTAGLIAA FT LRDGCPVGPPPPERGWEKLVSDDDDDVNDNVSTSVRDLTAADSNKPSTTSKNLKFTIMS FT YNVLCERYATSTLYGYTPSWALSWSYRKDLIMQELGGYNADIICLQEVDVENYDTFFAP FT QMSLKGYKGVHFPKSRVRTMNEVERRIVDGCATFFKTSKYVMHEKMVIEYNQAPSLRRQ FT DIKLTSNMYNRVMTKDNISVITLLENKENGSRLIVANCHIHWDPQFRDVKVIQVAMLMD FT EIAQVATKFRNMPSKIPSDQLKDERPTYPEYLKIPILICGDFNSVQGSGVYDFLSSGSI FT SQNHEDFMNNDYGEYTVNGRSHAFNLKSAYGESEALSFTNYTPGFKGAIDHIWYTGNSL FT EVTGLLKGVDKDYLSGVVGFPNAHFPSDHICLLAEFKVKQEKTPLPSSKFNNDKK" FT misc_feature complement(2285..2353) FT /note="Match to PF00560 LRR, Leucine Rich Repeat Score FT 20.15" FT misc_feature complement(2354..2419) FT /note="Match to PF00560 LRR, Leucine Rich Repeat Score FT 22.68" FT CDS join(complement(5570..5876),complement(4263..5356), FT complement(4038..4206),complement(3724..3988), FT complement(3577..3673)) FT /db_xref="GOA:O13282" FT /db_xref="SWISS-PROT:O13282" FT /label=taf72 FT /note="SPCC5E4.03c, len:643" FT /gene="taf72" FT /gene="SPCC5E4.03c" FT /product="tfiid subunit taf72p." FT /protein_id="CAA21958.1" FT /translation="MSATNGPQPQDLNRIVLDYLAKKGYSRTEAMLRLEASGSGVSVEE FT KLKSIEETPDAYTHTYTILRDWVDSSLELYKAELHRILFPIFVHSYLNLLSQDHYEAAK FT QFYELFKDDHTDLHDFDVKNLKSLSLPSHVAEDRTAQQYRQNKYQLHFSRITFDLLLHF FT LFENVSNGGSIIIKLINQHIDIHIVPGRPTVLENAKVINEQEGITGQSFERGDAQLQPV FT KLQQMPMDKEMEKIVEMDLEEEDMMHQNDPNNQSPKLLKEFRKLHEPNAEDAPSRDYIP FT LPPHKGVDILSEVEAVKDWSKRLHLGPRASLPSVCMYTFHHTNNNMNCAEFSPDSTMIA FT CGFQESYIRLWSIKADKKSLPKSTSVEDSDGSVRLLSHSGPVYGTTFSPDNKYLLSCSE FT DASARLWSVDTKTALVAYKGHTGPVWDVAFGPFGHYFATASHDQTAQLWSCDHIYPLRV FT FAGHLSDVDCVTFHPNSAYVLTGSSDKTCRLWDVHRGHSVRVFNGHTQPVTAVAIAPDG FT HTMASADSEGLIHLWDIGTGRRIKTMRGHRGNIYSLSFSRESTVLVSGGSDCTVRAWDV FT FKTNYNNPVSSSLTGSVVTPFSAKTSTFNEVNWSTSPDQMVALYTKQTPIFNVSFTRRN FT LCLAISVS" FT misc_feature complement(3674..3690) FT /note="ctaaccttctcaaacag, splice branch and acceptor" FT misc_feature complement(3718..3723) FT /note="gtatga, splice donor sequence" FT misc_feature complement(3831..3875) FT /note="PS00678 Trp-Asp (WD) repeats signature" FT misc_feature complement(3834..3950) FT /note="Match to PF00400 WD40, WD domain, G-beta repeat FT Score 43.30" FT misc_feature complement(3989..4003) FT /note="ctaatttgattaaag, splice branch and acceptor" FT misc_feature complement(4032..4037) FT /note="gtatgt, splice donor sequence" FT misc_feature complement(4036..4125) FT /note="Match to PF00400 WD40, WD domain, G-beta repeat FT Score 29.54" FT misc_feature complement(4135..4206) FT /note="Match to PF00400 WD40, WD domain, G-beta repeat FT Score 32.59" FT misc_feature complement(4207..4221) FT /note="ctgacttgtatttag, splice branch and acceptor" FT misc_feature complement(4257..4262) FT /note="gtatga, splice donor sequence" FT misc_feature complement(4317..4415) FT /note="Match to PF00400 WD40, WD domain, G-beta repeat FT Score 35.53" FT misc_feature complement(4404..4520) FT /note="Pfam match to entry PF00400 G-beta, WD domain, G-bet FT a repeat" FT misc_feature complement(4443..4532) FT /note="Match to PF00400 WD40, WD domain, G-beta repeat FT Score 36.09" FT misc_feature complement(5357..5370) FT /note="ctaacgtgctatag, splice branch and acceptor" FT misc_feature complement(5564..5569) FT /note="gtaagt, splice donor sequence" FT CDS join(7244..9333,9373..9674,9716..10010,10049..12848) FT /db_xref="GOA:P18296" FT /db_xref="SWISS-PROT:P18296" FT /label=cut1 FT /note="SPCC5E4.04, len:1828" FT /gene="cut1" FT /gene="SPCC5E4.04" FT /product="cut1 protein." FT /protein_id="CAA21959.1" FT /translation="MSTRSIVTSKVSWTPEKFISALSYPEHCSITLVKRLKASVKLKDL FT KQNISRDAPSWTFEHLFVAFKCAVSNLAKQWAELSTTDKEKTRRMFCTPSRLNTAHRPE FT VFYLLECCTYILEQMQVVTKNTSHLYDCIRSGVSICNRLLDMEIFEPAISLLMKTHKNL FT IILLTYRDHDAIPTATLLNPTLDVSEIQLESCLFVPMVPASYFLNIGTIVVTFQLNVLR FT CLSLSQINGLSLNTINNLQSEDGPFQWIERSFPSQVQLANSRREILARLLTRFSMIQNN FT ALQSFKLLILSIALWLNILSSQRADDKEFDVNQLETRILQLFSKVVQLCKSEDIEGSIL FT NKDMTQLHHLLENLSKESRLHILLQLSQLYYKYNDFQLSAAYVIRGYSLSFEDISFKLK FT FLLFSFRLSIHDNSICFPFNLIQELSSLQQLFVENALPYSEALHLLDSIERSFRLFNDS FT TVFDDTVFALNISEILSWILSSVVRDILVEDELLNLQLKIRKFLMFTFHIIRSFSELTK FT FQSSLEGCLNLAAYYEDAEFPQKLSNHLYNLCVKSSNVNYARECISLSIKIAVSHKLTN FT DETYLLKILKNFQLRYHDSLQLQEKCDVLHTTFNQLDLYVGTTSVGKSSVLDNILKRIF FT NSLTSINDSNIEKLLESISYSLLKLFFKCANEGSRYNASAALSFKLSLMLHEKEEVLLL FT KTNVSCVLANHGYNDIKFEEMVLCVIKGDQNLLEHNSNNNAKLALNESLLCSWENLLCY FT RRAEDDSRILTIIESWTIFISRFSSVISRCSFTDFEINSILNFFFCFLHTVEPSGKLTF FT ELAFLEIFYELFNCLLHLQFSKYLVIIGTLLSDKYMTLGFSGKAHLFYTKCYSYLRQCK FT SSPFINFWNVSYGKYLILTGNTDKGILQLKKYSLSSEEDFNSNGLSRTVSLNLLLYERI FT QLSDALFQLGYTTVSLGFIMQNLKVIKGLFSKSSKEHFNGGKYITWRLFAVSAHSNVCA FT ARIYEHMGQAREAEFFYRQACSISEKMPFSCFSATFQLRLCSLLTRAGKLEKGEKILFD FT LTEAMKSTDTYHKLLWNYGAAEVCATKSELDGAICHYSECVKLLEIIKSEYYLFFNRNR FT EKSLTKGIKRLSLSSQPTFVTESNTTEFDDWSILQNTAANLLRLISMFELKRGNLEIAK FT ALMTDSTKCSIASFFNIVSANILKSKLIVCEADSTLFGDPVLRTLPDSVISLPGISHKF FT QKNQSKTKALGENTGFRKGSKRLDYLRERLKINLQNVRLSCEIIFSNAYERSSVCVCRE FT VNELISYSTIMQSALTTIGETTDVDSSSASFFLEIPKALGFHRRREAQKFRNQHKELHF FT SSLEQILNSRLSIPDVRTFQDNFIDSLPSIWNVVSITINNSGEDLFISKIRKGHSPLIF FT RLPLQRHNSRDADEEILVFTKAQTELFRIISKSNQMAQNGKHYTRREDKETWWKERRHL FT DQCLQQLLENIEISWLGGFKGIFNPHKIDTSLFAKFSSQFQNIIAKNFNMDKKTPVPTL FT SPEILELFITLGKPGYEGYEQLLEDLIYFILDIFQFRGLHFAYDEIDTDQLSMDLQDAL FT NAYFNNYVSEENRSHTVLVLDKSVHQFPWESLPCLNRQSVSRVPSLSILRDILSQSFVV FT NGEYVEVRKEAGSYILNPSLDLKHTQEMFEHKLVEGGWKGLIASQPSNRDFIKMLSGND FT FFLYFGHGGGEQYTTSYDLATLKRCAVTILMGCSSGALYECGSFEPWGTPLDYLSAGCP FT TLVANLWDVTDKDIDRFSLKMLESWGLFENKAPFVNSTSICTAVSESRSCCHLRYLNGA FT APVIYGIPAYIIP" FT misc_feature 9092..9115 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 9334..9339 FT /note="gtaagt, splice donor sequence" FT misc_feature 9362..9372 FT /note="ctgacatttag, splice branch and acceptor" FT misc_feature 9675..9680 FT /note="gtaagt, splice donor sequence" FT misc_feature 9702..9715 FT /note="ctaattgtttatag, splice branch and acceptor" FT misc_feature 10011..10016 FT /note="gtatga, splice donor sequence" FT misc_feature 10036..10048 FT /note="ctaacgagctcag, splice branch and acceptor" FT CDS complement(13088..14224) FT /db_xref="GOA:O94305" FT /db_xref="SPTREMBL:O94305" FT /label=SPCC5E4.05c FT /note="SPCC5E4.05c, len:378, SIMILARITY:Saccharomyces FT cerevisiae, YKJ4_YEAST, hypothetical 35.5 kd protein in FT cwp1-mbr1 intergenic region., (313 aa), fasta scores: opt: FT 459, E():7.8e-19, (31.2% identity in 269 aa)" FT /gene="SPCC5E4.05c" FT /product="hypothetical protein, possible phosphoslipase" FT /protein_id="CAA21960.1" FT /translation="MADLYTKDWTDVKDKPVARVVFIHGFGEHVNAYPEFFEALNERNI FT EVYTFDQRGFGHSRKGGPKKQGCTGGWSLVFPDLDYQILRASDTELPLFLWGHSMGGGL FT ALRYGISGTHRHKLAGVIAQAPMLRCHPDTEPNFLLRKALTLVSKVHPNFLFDSDVQSQ FT HITRDEAVNQRLQDDPLVSSVGSLQVFSDMLNRGTKTIELAPQFFLPLLITHGTDDNVT FT CSDSSKEFYENAGTKDKTYQSYPGFYHSLHIEKKPEVYEYLDKVAAWIYEHSKPSETVK FT SEQETAVEHPKPTATTSAPSASPTGVPVEEESHKATSDAVPPAEAKPEPVPASAAERAP FT TSESTTVPETIVASTTKVISEPAPRVTTAATADIVTNK" FT misc_feature complement(13424..14092) FT /note="Pfam match to entry PF00561 abhydrolase, alpha/beta FT hydrolase fold" FT CDS join(complement(15405..15426),complement(15054..15337)) FT /db_xref="SPTREMBL:Q9P7Z6" FT /label=SPCC5E4.10c FT /note="SPCC5E4.10c, len:101" FT /gene="SPCC5E4.10c" FT /product="hypothetical protein" FT /protein_id="CAB71863.1" FT /translation="MKERHGLGPLPWYMKTDKISIDETSNNMSSKYRAPQDDPMFLVEK FT LLSNRKTKNPESDRRRQSRKKKSTQIQASDEMKHRRHHVHKVHHYSQKQSSSTTRR" FT misc_feature complement(15338..15352) FT /note="ctaatttctttgtag, splice branch and acceptor" FT misc_feature complement(15399..15404) FT /note="gtatgt, splice donor sequence" FT CDS join(16215..16325,16432..19743) FT /db_xref="GOA:P53692" FT /db_xref="SWISS-PROT:P53692" FT /label=rad18 FT /note="SPCC5E4.06, len:1140" FT /gene="rad18" FT /gene="SPCC5E4.06" FT /product="dna repair protein rad18" FT /protein_id="CAA21961.1" FT /translation="MTTELTNVSLEEAITEKTSENRRKRDSDVLQTEEVDLSNVKRIRA FT SRNQDNRPERQSRLQRSSSLIEQVRGNEDGENDVLNQTRETNSNFDNRVGVIECIHLVN FT FMCHDSLKINFGPRINFVIGHNGSGKSAILTGLTICLGAKASNTNRAPNMKSLVKQGKN FT YARISVTISNRGFEAYQPEIYGKSITIERTIRREGSSEYRLRSFNGTVISTKRDELDNI FT CDHMGLQIDNPMNILTQDTARQFLGNSSPKEKYQLFMKGIQLKQLEENYSLIEQSLINT FT KNVLGNKKTGVSYLAKKEEEYKLLWEQSRETENLHNLLEQKKGEMVWAQVVEVEKELLL FT AEKEFQHAEVKLSEAKENLESIVTNQSDIDGKISSKEEVIGRAKGETDTTKSKFEDIVK FT TFDGYRSEMNDVDIQKRDIQNSINAAKSCLDVYREQLNTERARENNLGGSQIEKRANES FT NNLQREIADLSEQIVELESKRNDLHSALLEMGGNLTSLLTKKDSIANKISDQSEHLKVL FT EDVQRDKVSAFGKNMPQLLKLITRETRFQHPPKGPMGKYMTVKEQKWHLIIERILGNVI FT NGFIVRSHHDQLILKELMRQSNCHATVVVGKYDPFDYSSGEPDSQYPTVLKIIKFDDDE FT VLHTLINHLGIEKMLLIEDRREAEAYMKRGIANVTQCYALDPRNRGYGFRIVSTQRSSG FT ISKVTPWNRPPRIGFSSSTSIEAEKKILDDLKKQYNFASNQLNEAKIEQAKFKRDEQLL FT VEKIEGIKKRILLKRREVNSLESQELSVLDTEKIQTLERRISETEKELESYAGQLQDAK FT NEEHRIRDNQRPVIEEIRIYREKIQTETQRLSSLQTELSRLRDEKRNSEVDIERHRQTV FT ESCTNILREKEAKKVQCAQVVADYTAKANTRCERVPVQLSPAELDNEIERLQMQIAEWR FT NRTGVSVEQAAEDYLNAKEKHDQAKVLVARLTQLLQALEETLRRRNEMWTKFRKLITLR FT TKELFELYLSQRNFTGKLVIKHQEEFLEPRVYPANRNLATAHNRHEKSKVSVQGLSGGE FT KSFATICMLLSIWEAMSCPLRCLDEFDVFMDAVNRLVSIKMMVDSAKDSSDKQFIFITP FT QDMGQIGLDKDVVVFRLSDPVVSSSALPPSTAP" FT misc_feature 16326..16331 FT /note="gtatgt, splice donor sequence" FT misc_feature 16411..16431 FT /note="ttaatattttatttttaatag, splice branch and acceptor" FT misc_feature 16645..16722 FT /note="Match to PF00470 RecF, RecF protein Score 22.39" FT misc_feature 16690..16713 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 18040..18075 FT /note="PS00192 Cytochrome b/b6 heme-ligand signature" FT CDS 20057..20503 FT /db_xref="GOA:P36585" FT /db_xref="SWISS-PROT:P36585" FT /label=rpl27a or rpl28-1 FT /note="SPCC5E4.07, len:148" FT /gene="SPCC5E4.07" FT /gene="rpl27a.2" FT /gene="rpl28-1" FT /product="60s ribosomal protein L27a.2/L28A" FT /protein_id="CAA21962.1" FT /translation="MPTHVSKTRKLRGHVSAGHGRIGKHRKHPGGRGKAGGLQHLRSHF FT DKYHPGYFGKVGMRRFHLMKNPLWRPTVNLDRLWTLLPNEARDKYLGKNTEVAPVINVL FT QSGYGKVLGKGRLPETPVIVQTRYVSRRAEEKIKQAGGVVELIA" FT misc_feature 20384..20482 FT /note="Pfam match to entry PF00256 L15, Ribosomal protein L FT 15" FT CDS 21136..21690 FT /db_xref="SPTREMBL:O94306" FT /label=SPCC5E4.08 FT /note="SPCC5E4.08, len:184" FT /gene="SPCC5E4.08" FT /product="hypothetical protein" FT /protein_id="CAA21963.1" FT /translation="MDQERKLQFLLSIAAETYAISPSLSSHYLRRMFSLLEEWNLETDP FT KTLLHGCSKCGSLFIFGRNIKLRTISSERKARTDLKKGEVSRLGTNLEINCLVCSYVHE FT IPLGVPLRLHQSKQALRAKAIAESSSTKLESRKSAHNAKVKQRQRLRASGLNGILDRKK FT KKDEVAKSTSSLSLQDFMSPI" FT misc_feature 21265..23000 FT /note="nominal overlap with cosmid SPCC16C4, EM:AL031535 S. FT pombe chromosome 3" FT CDS join(22264..22571,22655..22920,22999..23000) FT /db_xref="GOA:O74446" FT /db_xref="SPTREMBL:O74446" FT /label=SPCC16C4.01 FT /note="SPCC5E4.09, len:191; entirely contained in c16C4, FT SIMILARITY:Saccharomyces cerevisiae, Q03441, YDL001W, FT hypothetical 49.9 kd protein., (430 aa), fasta scores: opt: FT 340, E():1.9e-16, (40.7% identity in 189 aa)" FT /partial FT /gene="SPCC5E4.09" FT /gene="SPCC16C4.01" FT /product="hypothetical 51.9 kd protein" FT /protein_id="CAA21964.1" FT /translation="MSNRIGPQRSTKTAAKLRLLPSTEEFDDFRRQDTGREVYSQIPQI FT EGSTAKRDAEHLGKRHREFLPRVTAYCTCDTFRVDLLFKFFQSRRSSHKTRPKQFDECI FT YSPYSYNNEETTDLLPDTLESSRGTLNRESSQESLQSIFEESGLDRNQPLFREVFCFTY FT GVVVLWGYTIDEEHRFLRELGRFEIEKLK" FT misc_feature 22572..22577 FT /note="gttagt, splice donor sequence" FT misc_feature 22640..22654 FT /note="ctaacattataacag, splice branch and acceptor" FT misc_feature 22921..22926 FT /note="gtatgc, splice donor sequence" FT misc_feature 22978..22998 FT /note="ttaacatttgtaatttttag, splice branch and acceptor" XX SQ Sequence 23000 BP; 7301 A; 4005 C; 4326 G; 7368 T; 0 other; gatccctcga tttatcgttt gtgaccaggg aggcagtcag gcacggtttc ttctttctcg 60 ccttaatcct tctgaaacgc acaacactac gtctatgtat ggtgctccac ctgctcatgc 120 tattttaact gatgatgtct ccttacaaac cttcatgagt catctgaaaa aacttgccgt 180 agctgtttca taaatgcact ttatgaaatc tataaactac cagcccttac ttgtagtcat 240 cgtttttaag aagtttagtc ttttggtgat tctcataaat aaaaagcttt ttatgtttga 300 taaacttctt ggtctctcca gctgactatt ataaacatta atgaatgatt aaaatttcag 360 cacttttggc ttgagtctag gatagcatag tcttgcttat caatattatt tcgtttactg 420 atgttatatt tctctagtat tacgctcgtt gtaatttgtt ggttttttaa aatagataaa 480 tattttatga attttttgtg aagttatgtt gagcaaaata aggatatctt caacacaatc 540 gatttttaga gatggttgaa tgttgatgaa atggcgaagc tcatttttat tatgaaaata 600 aaaaaatcaa cgttttaatg caaaccatca gtacgatgtg tggcggttca ccccttgtta 660 atgctaattt ccaataaaag taaaacgaat aactacgtaa acaaaaacga aacctcaatg 720 atttacaatt tatctattca aattattacg acaaggaaaa ttacactgct ttgatatcta 780 tgtaaactta accaaatacc tggtacttgc gaaatgcaga atcatacatc aaatccatct 840 acttgctact aagtatcact ctaaaatcta caaacacgac aaaaactaac aatcattttt 900 tatcattgtt aaactttgat gaaggtaagg gtgtcttctc ctgtttcact ttaaactcgg 960 ccagcaagca aatatgatca ctagggaagt gtgcgttagg gaaaccaaca acgccggaaa 1020 gataatcttt atccactcct ttcaacaaac cggttacctc caagctattg ccggtgtacc 1080 aaatgtgatc aatggcaccc ttaaagccag gtgtatagtt agtgaaggag agagcttcag 1140 attcaccata tgcagatttc aaattaaatg catgagaacg tccattaaca gtgtattctc 1200 cgtaatcatt attcataaaa tcttcatgat tttggctaat gctaccagat gataaaaagt 1260 cataaacacc actgccttgg acggaattaa aatctccaca aattaagatg gggatcttta 1320 aatactcggg ataggtaggt ctttcatcct ttaactggtc agaaggaatc ttggaaggca 1380 tattacggaa ttttgttgca acctgtgcaa tctcatccat gagcattgca acttgtataa 1440 ccttgacatc cctaaactga ggatcccaat gaatatgaca atttgcaacg atcaatcgcg 1500 atccattttc cttattctca agaagagtaa tcacactaat gttatcttta gtcataacac 1560 ggttgtacat gttagacgtt agtttaatgt cttgcctacg aagagatggt gcttgattat 1620 attctatcac catcttttcg tgcatgacat atttagatgt tttgaaaaat gtagcacaac 1680 catcgacgat gcgacgttca acctcattca tagttcgtac gcgacttttc gggaagtgga 1740 cacctttata acctttcaaa ctcatttgtg gagcaaaaaa agtatcatag ttctcaacat 1800 caacttcttg caaacaaatg atatcagcat tataaccacc taattcttgc atgattaaat 1860 ctttgcgata cgaccaagag agtgcccatg aaggagtata gccatacaat gtggatgtag 1920 cataacgttc acaaagcaca ttataactca taatagtaaa cttgagattc ttagatgttg 1980 tagagggctt gttagaatca gcagccgtta aatctctaac agaggttgaa acattgtcat 2040 taacatcatc atcatcatcg gaaacaagtt tttcccatcc acgctcagga ggaggagggc 2100 caacagggca accatcgcgc aaagcagcaa ttaaacctgc agtaccactt tccatgattt 2160 gattcttgta aacgtcttga agaggattac cttcaatacc aagaattttc aattggaaaa 2220 gggtaccgag ttcggcaggt attacactaa tcatattatc aaacaatagg acttctctaa 2280 gctcagtaag taaaccaagc tctggtggaa tagttttaat gctgtttcca gaggcatcca 2340 aaataaccaa attcttcagt ttgccaattt caggtggtaa tcgggtaaga ttattatggt 2400 ttatgtataa ttcagtcaaa aaagagaatt taaataaatc agtgctcaca tttctcaaac 2460 caataccacc aaggtccaaa caagtccaat cccgtctctc tttcttagag tcagatttcg 2520 acttttggtc atcaaccgca acagaagaag tggttgtttt tgacgtactg tttaaggtag 2580 taccactgga agtgtttaat gttgttgagg tcgtcaatgt tgtagtagtg gagctagtat 2640 tgtactttcc ccctaacgag gataagccag cagcattagg gcctccggta aaagctccag 2700 tccgagcatt gtaattcatc gaaaacccag gtcctccact tcgtgctaaa gccgcagcat 2760 tatgagctcg ttggtgtggt gaactgaagg acctggactg agttgcaagt gcaatttgct 2820 gtttccaatg ttcagaaata ttactatttt ctaaagctgg cgaattctgt acagataata 2880 ttgctgcatg ttgatggtct ggcgtcaaca gccccgggtg cgctcctgga taaattgtac 2940 cttgcgtata cctaggatta aacatagacg gtatctcgca aaatatcaaa gtcgagatga 3000 attctaattt acaacattca ctatatatac aataaaagtg aggttgttgg tgaacggcaa 3060 gagtcgaacc ccgtgatagc ttataggtgg gatacgaaag ctcaccacca agatttgaga 3120 cgaaaactca gtgtcctgtt aatcgttttt taggtatata attgcatatg aatgctttca 3180 attaattcat attattaatt ttttttctaa ataatataat ttagggtcca aacatgaaat 3240 tattttagct tatgtttagc gctgttatgg tctatgtaaa tattggagct actgaaaaat 3300 ttaatatata atgtatcatc agaagtcctt tatgaagttt ataatattaa aagcttttcc 3360 ggaacatcaa atatgaatta ttcagcctaa tttcgattcc gatacatgga tgtctcaaag 3420 ttgttaaaag gcagttagtt gttgactcat tatcgtaaag taagataatg tttaatattt 3480 aaattaaatt ttttataatc tttttttata taatgccaaa tttcttaaag tatggacggg 3540 aagaaacata ttgaagatca aaaaaggttt atttatctaa ctaacgctta ttgctaagca 3600 aaggttacga cgcgtaaagg agacattaaa tataggggtt tgcttcgtat aaagagctac 3660 catttgatcc ggactgtttg agaaggttag taaatatatc gattccatta cattttctca 3720 taccttgtag accaattgac ttcattaaat gtggatgttt tagcagagaa aggtgtaaca 3780 acacttcccg ttagagaaga agaaacagga ttgttgtaat tagttttgaa aacgtcccaa 3840 gctctcacag tacaatctga ccctccgcta acgaggaccg tggattcgcg agaaaatgac 3900 aaagagtata tgttgcctct gtgacctcgc attgtcttta tacgccttcc tgttcctatg 3960 tcccaaaggt gaattagacc ttcactgtct ttaatcaaat tagtaaaatc attagtaata 4020 acaaatgtat aacataccag cacttgccat agtatgacca tctggggcaa tcgcaacagc 4080 agttaccggt tgggtatgtc cattaaaaac acgaacagaa tgtcctctat gtacatccca 4140 aagcctgcat gttttatcgc ttgatccagt tagcacataa gcggagtttg gatgaaaggt 4200 aacgcactaa atacaagtca gtcataagga aacacatttc ttaaaaaaga taataatcat 4260 acgtctacat cacttaaatg cccagcaaaa actctaagtg ggtatatatg atcacagctc 4320 caaagttgtg cagtctggtc atgagaagca gtagcgaagt aatgaccaaa cggaccaaag 4380 gcaacatccc aaaccgggcc agtatgtccc ttgtaagcta ccaaagcagt ttttgtgtca 4440 acagaccaca gccgggcgct agcatcttcg gaacaagata gtaaatattt attatcggga 4500 gaaaatgtgg tgccgtaaac aggaccagaa tgactcagta aacgtactga gccatctgaa 4560 tcctctacag aagttgactt aggtaatgat tttttgtcag cctttattga ccatagccgt 4620 atataacttt cttgaaaacc acaggcgatc attgtggagt caggagaaaa ttcagcacag 4680 ttcatgttgt tattggtgtg atggaatgtg tacatacaaa cactaggaag ggaggctcta 4740 ggtccaagat gtaatctttt actccaatct ttcacagcct caacttctga aagaatatca 4800 acacctttat gaggaggaag agggatataa tctctagacg gagcatcttc agcattaggt 4860 tcatgcagct ttctaaattc ttttaatagt tttggagatt ggttatttgg atcgttttgg 4920 tgcatcatat cctcttcttc taagtccatc tctacaattt tttccatttc tttgtccatt 4980 ggcatttgtt gcagctttac aggttgaagt tgagcatctc ctcgttcaaa ggattggccg 5040 gtaatacctt cttgttcatt gataacttta gcattttcca agacggtggg acgtccggga 5100 acgatatgga tatctatatg ctgattgatt aatttaatga taattgaccc accgtttgaa 5160 acgttttcaa ataagaaatg aagcaataaa tcaaatgtta tcctagaaaa atggagttga 5220 tatttatttt gccggtattg ttgagcagtg cggtcttctg cgacatggct tggaagactc 5280 agcgatttta agttttttac atcaaagtca tgaagatcag tatgatcgtc tttgaagagt 5340 tcgtaaaatt gctttgctat agcacgttag taaaattatc atttatcctt ataaagaatt 5400 aaatatgggt ggtcaagtgg aatgagtttc agaaataaag acaagttgta aactcaatag 5460 ataaagaaac taataagtat ttagaatagt tcaaataccc ctcttgttcg tagatcatcg 5520 aaacaaacat gtaacaaatt cgtaacctcc tccaatatga ccaacttacc agcttcataa 5580 tgatcttgag acaagagatt aagatatgag tgaacaaata taggaaataa tatcctgtga 5640 agttcagctt tgtacaattc taacgaacta tccacccagt ctcgtaagat cgtatacgtg 5700 tgtgtgtatg catctggagt ttcctcaatg ctttttaact tctcctctac tgacacgcca 5760 gaacccgatg cttccaaacg aagcatcgcc tcggtccttg agtatccctt cttcgcaagg 5820 taatccagaa caattctgtt cagatcctgc ggttgcggcc cattagtggc agacatggtt 5880 aaattctcca atactctagc ttgaagaaat taattagaat ccaaatataa atctacaaat 5940 gaccgtgatt catataatta cctgcgcaga gctcaaagca acttgctagg aagtagcata 6000 tgtcgagttc gtgtctatta acataccatt gtgtaccacg ctaaattggg aatttgcagg 6060 atttatgaat aactgaaatt tggaaaggtt ccacagtgtc tgtgagcgtt ttgatgtcga 6120 aatcctatct aaattactat ttcttttgtc ctactcaaaa atgaactgtc tatgaaattg 6180 ttttaatgtc aacacaggat tgcgaggcaa tgaacgctag aaaaaaaaaa taaataaata 6240 aaagttttgc atagtaaaac tttttcaatt agatactttt taaaattctt ttttgatttt 6300 caattcggtt ttaaaaactt tcacttactt tttttttaga agtttcatcc caatttcggg 6360 atgtttataa ttttttaatt aaattatagt agggcccctt attaaaataa aactaaatgt 6420 tgggttgaaa tttaaatagg gaaaatgtag aagttttttt taaaaaattc aaaaaattgg 6480 gaaatttcat atttccttca aaatcattag tttataacaa aaattgatgt agcattgata 6540 aaatgagttt atcagaaatt atatgttttt tttcctgtta cagatttgta tggttttgag 6600 tcttaatcgg tttatttatt tattgatata tttatttaca ttattgaaat ttacaaatag 6660 taggttgcga tgaagtaatg gactgtagat aataactgta aactatcaat tatttacatt 6720 catttttaat tatatttaat tttcttcttt acagttttct ttcttttgga ccagttttag 6780 ggatttggtg gtaagtactg tgttttcatt tgccttaaca tccaaagcat ccttgctacc 6840 aactagccta tcttcatcca gcgagacgac ttgacagttt tttcgtttta gacgaaataa 6900 aaaccaacag ctccaaattt cgactattgc aatgttctaa ttaatgctga taatattcta 6960 ttggttggga agatcgatta atctactttt cataagcata taataaaaca tctacatgat 7020 ttttaagtca ctaatatttt cctcttctca ataattagta atataacttt gcgaactgaa 7080 aatcactgtc aaattattaa atcttatatt ttggtcgata tttgctattg gcttagttat 7140 ttcttgcaac ctattcttca tgaacggcgt taaataattt aaatcccttt tattgttgta 7200 actgttgctg gttaatattt tttactattc attcgtttcc attatgtcta caaggtcaat 7260 cgttactagt aaagtttctt ggactccaga gaagttcatt tcagctctca gttatcctga 7320 gcattgctct attactctcg ttaagcgact caaggcttct gtaaaattaa aggacctcaa 7380 gcaaaatata tctcgtgatg caccttcgtg gacgttcgag catttgtttg tggctttcaa 7440 atgtgcagtc agtaacttag ctaagcaatg ggcggagcta tccactacag ataaggagaa 7500 aactagaagg atgttttgta caccttctag attaaatacg gctcaccgtc ccgaggtttt 7560 ctacctgtta gaatgctgta catatattct cgaacaaatg caggtggtaa ccaaaaatac 7620 aagtcatttg tatgattgca tccgtagcgg ggtttcaatt tgtaatcggc tcctggacat 7680 ggagattttt gaaccagcta tcagtctttt gatgaaaact cataaaaacc ttataatttt 7740 actgacatat cgggaccacg atgccatccc tactgctacc cttcttaatc ccactttaga 7800 tgtttcagaa atccaattag aaagctgcct ttttgttcct atggttcctg cctcttattt 7860 cttaaatata ggcactatcg ttgtcacatt tcagctcaat gtattacgat gtttatcttt 7920 aagtcaaatt aacggtttgt ctttgaatac aatcaataac ttacaaagcg aagatggccc 7980 ttttcaatgg attgaaagaa gctttccttc ccaggttcaa ttggccaatt cgagaagaga 8040 aattttagct cgtttgttga caagattttc catgatacaa aataacgcct tacaatcgtt 8100 caaactttta atcctctcta tagctttatg gttgaatatt ctttcttccc agagagctga 8160 cgataaagag tttgatgtaa atcagcttga aacgagaatc ctccaacttt tctcaaaagt 8220 tgtccaatta tgtaaaagcg aagatattga aggatctatt ttaaataaag atatgacaca 8280 acttcatcat cttctggaaa atttatcaaa agaatcgagg ttgcatattt tgcttcaact 8340 ttctcaactt tattataaat ataatgattt ccaattaagc gctgcatatg tcattagagg 8400 ctattctttg tcatttgaag acatcagttt taaattaaaa tttttattat tttcttttcg 8460 attatcaatt cacgataata gcatttgttt tccgttcaat ttaatccaag agttgtcgtc 8520 acttcagcag ctctttgtcg aaaatgcttt accatattca gaagctctac atttattgga 8580 ttcaatagag cgatcatttc gacttttcaa tgactcgacg gtttttgatg atactgtatt 8640 tgctttgaac atatcagaaa ttttatcgtg gatactctca tcggttgtga gggatatcct 8700 tgtcgaggat gagcttttaa atctccaact taaaataaga aagtttttga tgtttacatt 8760 tcatataatt aggtcattta gtgagttgac taaatttcaa agttctctgg aaggctgttt 8820 aaatctcgca gcctactatg aagatgctga atttcctcaa aagctttcca atcatcttta 8880 caacttgtgt gtaaaatctt ctaatgttaa ttatgcacgt gaatgcataa gtttgagtat 8940 caaaattgct gtatcacata aattgactaa tgatgaaaca tatctcctga aaattttaaa 9000 aaattttcaa cttcggtacc acgattcttt acagttgcaa gaaaaatgtg atgtactcca 9060 tactacattc aatcaactgg atctctatgt tggaactaca tctgttggaa aatctagtgt 9120 attggataac attttaaaac gtatattcaa ctctttaact tctataaatg attcaaatat 9180 agaaaaattg cttgaatcaa taagctattc cttgctcaaa ctttttttta aatgtgcaaa 9240 tgaaggttct cgatataatg catctgctgc tttatctttt aaattatctc ttatgttaca 9300 tgaaaaagag gaggtccttt tgcttaaaac aaagtaagta tttctacaat tttcttattt 9360 gctgacattt agtgtttctt gcgttttggc aaaccatggg tataatgaca ttaaatttga 9420 ggaaatggtt ctttgcgtta ttaaaggtga ccaaaatctc ctagagcata attccaacaa 9480 taatgcgaaa ttagctttaa acgagtcgct attatgctca tgggaaaatt tgctatgtta 9540 cagacgtgcg gaagacgata gtaggatact tacaataatt gagtcgtgga ctatttttat 9600 atctcgattt tcttcggtca tttctcgttg ctccttcaca gattttgaaa ttaactcaat 9660 tttgaatttt ttttgtaagt tttcaatcgt aaccggcgtt tctaattgtt tatagtttgt 9720 tttttacata cggtggagcc gagtggaaaa ctaacattcg agttggcttt ccttgagata 9780 ttttacgaac ttttcaattg tcttcttcat cttcaatttt ccaagtatct ggtcatcatt 9840 ggtactttgc ttagtgataa atatatgacg cttggcttct cagggaaagc tcacttgttt 9900 tataccaagt gttatagcta tcttcgtcaa tgtaaaagca gtccttttat aaacttttgg 9960 aatgtttctt atggtaaata tttgatttta accggaaata cggataaagg gtatgaagac 10020 tttgtgagat agttactaac gagctcagaa ttttacagtt aaaaaaatat tctctttctt 10080 ctgaagagga tttcaattca aatggtttaa gtcggactgt tagcctcaat cttttgcttt 10140 atgaaaggat acagctaagt gatgccctat ttcaactagg ctacaccact gtttctcttg 10200 gctttataat gcaaaattta aaggttatta agggattgtt ttctaaaagc tcaaaggagc 10260 atttcaacgg cggaaaatat attacttggc gacttttcgc tgtcagtgct cactctaacg 10320 tttgcgctgc aaggatttat gagcacatgg gacaggcgcg agaagccgaa tttttttatc 10380 gacaagcttg cagtatttct gaaaagatgc cgttttcttg tttttcagct accttccaat 10440 tgcgcttatg ctcactacta acaagggcag gaaagttaga gaagggcgag aagattttat 10500 ttgatcttac tgaggcgatg aaaagcacag atacatacca taaactttta tggaattacg 10560 gagcagctga agtatgcgca acaaaatccg agttggatgg tgccatatgt cactattcag 10620 aatgtgtaaa acttttagaa ataataaagt cagaatatta cctttttttt aataggaacc 10680 gcgagaagtc tcttacaaaa ggaattaaaa gactcagtct ttcaagtcaa ccaacttttg 10740 ttacagaatc taatactact gaatttgatg actggtcaat tcttcaaaat acggcagcca 10800 atttacttcg tctgatttct atgtttgagt tgaaaagagg aaacttggag attgcaaagg 10860 ctttaatgac tgactcgaca aaatgctcaa ttgcaagttt tttcaacata gtctcagcta 10920 atattttaaa atcaaagctt attgtttgtg aagctgattc cacactattt ggcgatcccg 10980 tcctacgtac tcttcccgat tctgtaattt cattacctgg aatttctcat aaatttcaga 11040 aaaatcaaag taaaacaaaa gcgcttggag aaaatacagg atttcgcaag ggatccaagc 11100 gcttagatta tttacgtgag aggcttaaaa tcaatttgca gaatgttaga ttaagctgtg 11160 aaattatatt ttctaatgca tatgagcgga gctctgtatg cgtttgcagg gaggtcaatg 11220 aattgatatc gtactcaaca attatgcaaa gtgcattaac cacaattggc gaaacgaccg 11280 acgtcgattc tagttcagcc tcattttttt tagagatccc taaagctcta ggattccata 11340 gacgtcgtga agcacagaaa ttcagaaacc agcacaaaga acttcatttt agtagtttgg 11400 aacaaatttt aaatagtcgg ttatctatac ctgatgtccg tacatttcaa gacaatttta 11460 ttgattcatt accgtcgatc tggaatgtcg tttctattac tattaacaat tctggagagg 11520 atttgttcat ctcaaaaata cgcaaaggtc attctccgct gatttttcgt ttaccattgc 11580 aaagacataa ttcacgtgac gcagacgaag aaatccttgt gtttacaaaa gctcaaaccg 11640 agctatttcg aattatctct aaaagtaatc agatggctca gaacggtaaa cattatacta 11700 gaagagaaga caaagaaact tggtggaaag aaagaagaca ccttgatcaa tgcttgcaac 11760 aacttttaga aaatattgaa atatcatggc tcggtggatt taaaggtatt ttcaatccac 11820 ataaaattga tacttctttg tttgccaagt tttccagtca atttcaaaac attatagcta 11880 aaaattttaa catggacaag aaaacacctg tccctacact gtcgcctgag atcctagaac 11940 tattcatcac cttaggaaaa cctgggtatg aaggttacga acagctttta gaggatttga 12000 tttattttat tttggacatt tttcaattcc gaggtcttca ttttgcatac gacgagattg 12060 atactgatca actatctatg gatcttcagg atgctctaaa tgcctacttc aacaattatg 12120 tctctgaaga gaacaggagt catacggtcc ttgtactgga taaatcagtt caccaatttc 12180 cgtgggaatc tttaccatgc ctaaaccgac aatcggtatc acgtgtgcct tcattatcaa 12240 ttctgcggga catcttgtcc caatcatttg tcgttaatgg agagtatgtt gaagtgcgta 12300 aagaagcagg ttcatatata ctaaatccta gtttggacct taagcatact caagaaatgt 12360 ttgaacataa actagttgaa ggtgggtgga agggattaat tgctagtcaa ccttctaata 12420 gagattttat taaaatgctt tcaggtaatg atttttttct atatttcgga catggaggag 12480 gagagcaata tacaacatct tatgacctgg ccactctaaa aaggtgtgca gtcactatac 12540 tgatgggttg tagttctggt gctttgtatg aatgtggctc atttgagcca tgggggactc 12600 ctttggatta tttgagtgct gggtgtccaa cgttagttgc aaacttatgg gatgtcaccg 12660 ataaagacat cgataggttc agtttgaaga tgcttgaaag ctggggactc tttgaaaata 12720 aggcaccttt tgtgaattca acgagtatat gcacagcggt cagcgaaagt cgttcatgct 12780 gtcatctacg ctatttgaac ggagcagctc ctgtgatata cggaatacct gcttatatta 12840 ttccataaac tgtctaaaat tcttacttct ttttatttat ttgaatcaac attgtttcaa 12900 cgccttctca tataaagttt ctcctattta acgattaatg cgagtgtatc tatgtaacta 12960 atgaaaataa tttattatct atatatgtac tttaatatca catttgcgtg caacttacag 13020 tacttgggta gcaaaacagt atcggtcatt aaaggttcca ttttgtaagg attgaacctc 13080 aaaaagttta tttattggtt acaatatcgg cggtggccgc agtagtaact ctaggagctg 13140 gttctgaaat taccttggtt gttgatgcca ctatggtctc aggaacagtg gtactttcag 13200 aagtaggcgc cctttctgca gctgatgctg gtacaggctc aggctttgct tcagcaggag 13260 gaacagcatc cgacgtggct ttatgtgact cctcttcaac aggaactcca gtaggagaag 13320 cagaaggagc agatgtagta gcggtaggct taggatgttc aacagcggtt tcctgttccg 13380 actttacagt ttcactaggc tttgagtgtt cgtaaatcca agcagcaact ttgtcaaggt 13440 actcataaac ctctggtttc ttctcaatat gcaaagaatg gtaaaatcct ggatacgatt 13500 gatatgtctt atctttagtg cccgcatttt cataaaattc ttttgaagaa tcggaacaag 13560 tcacattatc atcagtacca tgggttataa ggagaggaag gaaaaactga ggagctaatt 13620 caatagtttt cgtacctctg tttagcatgt cactaaagac ttgcaacgaa cctaccgatg 13680 aaacaagagg atcatcctgc aaacgttgat tgacggcttc atccctggtt atgtgttgac 13740 tttggacatc gctatcgaaa agaaaattag gatgtacctt ggaaaccaaa gtaagtgctt 13800 ttcgtaacaa aaagtttggt tcagtgtcag gatgacaacg aagcatagga gcttgtgcga 13860 ttacaccagc cagcttgtga cgatgtgtcc cactgatacc ataacgtaaa gccaatcctc 13920 cacccataga atgtccccat aaaaataggg gaagctccgt atcgctagca cgaagaattt 13980 gataatccag gtcaggaaat actagagacc aaccaccagt acaaccctgc ttctttggac 14040 ctccctttct tgaatgacca aaacctctct gatcaaaggt ataaacttca atattacgct 14100 cgttcaatgc ttcaaaaaac tctggataag cattgacatg ttcgccaaat ccatggataa 14160 aaacaacacg tgcaacgggc ttgtctttaa catcagtcca atcttttgta tataaatcag 14220 ccatttgaga gcaatagagc caaaaacaat cctggaaata tcacctgcgt tcaatgttgg 14280 ttctgagcag atagtgtaac gagattgttc tgaaggtgga ttccagaaag gatagaatga 14340 ttttaatatg aatgatatat atgctttata aaagttatga aatatgaaaa tataaaaact 14400 aaaattaaag tgtaaaattt tatttggctc gaagcatgtt gccaaagcta aagattcatt 14460 tattaaaata actaaacatt atgacctagc tttttttttt aaaaaaaaag aaaagaaata 14520 tacaaaacat caaatggctg gaatcagcta cctttgtacg ttcgactttc aacgctaatt 14580 cgatcttcga agatgcatac ttgacaagtg aacgaagaaa aatgtgaaaa gaaaaaccac 14640 aataagcatg caaagaaatc aagcgttagt ttcatacttc aatttcataa tttggatttt 14700 tgaagcaata acagaatggc attaaccata tagatagaag tatccttgca aaagattata 14760 gaagaaacaa atacttcaga aatcaataga aaaacatgat taaagtaaag atttgttttc 14820 tttaaataat ataaaagagt tattcgtata gagagtcatc attgaaggtg caattaggag 14880 gtcccagcat gtaaggattt aaaataaata cagctaaatg ccaaggtagc aagcataaag 14940 taaactaaat cttccgctag aaatagtaag tcataccttg ttagtaaatc attgtatcat 15000 tagatgatag aactggttta tacatatttg gaggtcaaat gaaaatatta aaattatcga 15060 cgagtagtag aggaagactg cttctgggaa taatgatgaa ccttatgaac atgatgtctt 15120 cgatgtttca tttcatcgct tgcttggatc tgagtagact ttttctttcg actctgcctt 15180 ctacgatcag attcgggatt tttggtcttc cggttcgaca gcagtttctc aaccaaaaac 15240 ataggatcat cttgaggagc gcgatacttt gaagacatat tattcgatgt ttcatctatg 15300 ctgattttgt ctgttttcat gtaccaaggg agtggtccta caaagaaatt agtaatgcga 15360 acaaaatcaa gatggtttct ccattggtaa aacaagaaac ataccgagtc catgccgttc 15420 tttcataatt tctagatcat ggcgattttc gctataaact ttttgacgtt tcctctccta 15480 atgctagtgt tagcactgca aattattaaa aaatcataaa ttagaagata tttttaaaag 15540 ctctaccttt tcttcctgtt cagcccaaaa attggcaaat tcaacttttg gctctgtttc 15600 tttcgaatct tcttcgtaaa cagtacctcg tagtcgtgct atccgacgtt tagattccta 15660 gaaggcatgt gtgagaaagt ataaataaga gagaggttga taattaatta cctctaggtc 15720 gttttttgct tgttctttgt ccgctgaaag tcttgccaat tcttcatctc ttctaactct 15780 ttcgatattt ttctcattat agactagaat aaatattaat gattgacctt tgggttttat 15840 agggacacac cgttccaact cttatgctta agcagattca gcggcatttt tagtttagag 15900 aagtcgcttt tatttcaaaa ttcgacaata atttagtcca attgtttatt caaatataaa 15960 tgttcattaa tgtacagaaa aatattaaca tcgaaaggac ttcaattaaa aaacttggaa 16020 aagtgaagga tcctggtcta cacgtatacc taccactaac aacggtggct attcactagg 16080 ttgaatatta tcgtgaagat ttattttttt cgttaaagag aattaaatta cttaaatttt 16140 tttgttaatt gattagttct tgtcgtgata tctttggtat ttagcgagag caacaaaaca 16200 gaggtccaaa gttcatgact acagagctta ctaatgtatc tttggaagaa gctatcacgg 16260 aaaaaacaag cgaaaataga agaaagagag attcagacgt tcttcaaact gaagaagtgg 16320 atttggtatg tttaaactct tgccgttttt ataacgaaac gcgttctcaa ttgcgagaga 16380 aaaggttctt tgttggttga aatttgtata ttaatatttt atttttaata gtcaaatgtg 16440 aaaagaattc gggcttctcg aaatcaagat aatagacccg aaaggcaatc tcgacttcag 16500 cgatcatctt cattgattga gcaagttaga ggtaatgaag acggagaaaa tgatgtcctc 16560 aatcagacca gagagacaaa ttcaaatttt gataaccgcg tgggagtcat tgagtgtatc 16620 catttggtga attttatgtg tcatgactcc ttgaagatta attttggacc tcgtatcaac 16680 tttgtcattg gtcataatgg tagcggaaaa agtgctatac ttacaggatt gactatttgc 16740 cttggagcta aagcctcaaa tactaatcgc gctccaaaca tgaaaagtct tgtaaagcag 16800 ggaaagaatt atgcccgaat ctctgttacg attagtaacc gtgggtttga agcataccaa 16860 cccgaaatat atggaaaatc tattacaatt gagcgtacta ttcgaagaga aggatccagc 16920 gaatatagat tgcgttcttt caatggaacg gttatttcaa ccaaacgcga tgaactagac 16980 aatatctgcg accatatggg tttacaaatt gacaatccta tgaacatcct tacgcaggat 17040 acagcacgtc agttcctggg aaattcaagt ccaaaagaga aatatcagct ctttatgaaa 17100 ggaattcagc tgaaacagct cgaagaaaat tactctttaa ttgaacaaag cttaattaat 17160 actaagaatg ttttaggaaa taagaaaact ggggtctctt atttagcaaa gaaggaagaa 17220 gaatataaac ttctgtggga acaatctcgt gaaactgaaa accttcataa cttattagag 17280 caaaaaaagg gggaaatggt gtgggctcaa gtggttgaag ttgaaaaaga gcttctgctt 17340 gcggagaagg agtttcaaca tgctgaagtt aaactttcag aggccaagga aaatttagag 17400 tcaatagtta ccaatcagtc tgatattgat ggaaagatat cttcaaaaga agaagtgatt 17460 gggagagcta aaggtgaaac tgacactaca aagtctaaat ttgaagatat tgtgaaaaca 17520 tttgatgggt atcgttcaga aatgaatgat gttgatatac agaagcgtga tatacaaaac 17580 agtatcaatg ctgccaagag ttgcttggat gtgtatcgtg aacaactgaa cactgaaaga 17640 gctcgagaaa acaatttggg aggttctcaa attgaaaaaa gagcaaacga atcaaataat 17700 ttgcaacgtg agatagcaga tttaagtgaa caaattgttg agcttgaatc taaaaggaat 17760 gacttgcatt ctgctctttt agaaatgggc ggcaatttaa ccagcttgtt gacaaaaaaa 17820 gactcaattg ccaacaaaat ctcagatcaa agtgaacatt taaaagtatt agaagatgtc 17880 caaagagata aagtttctgc atttggaaag aatatgccgc aacttcttaa actcatcact 17940 cgggaaacaa gatttcagca ccctcccaag ggacccatgg gaaagtatat gacagtgaaa 18000 gagcaaaaat ggcatttaat tattgaaagg atattgggaa atgttatcaa tggttttata 18060 gttcgtagtc atcatgacca attgatcctt aaagagctga tgaggcaaag caattgtcat 18120 gctacagttg tagttggaaa atacgatcct tttgactatt cttctggtga acctgattct 18180 caatatccta cggtgctcaa gattattaag tttgatgatg atgaagttct acatacgctg 18240 attaatcatt tgggaattga aaagatgtta ttgattgaag accgacgtga agcagaagct 18300 tatatgaaaa ggggcattgc taatgttacc caatgttatg ctctcgatcc tagaaaccgt 18360 ggatatgggt ttcgaattgt cagtacacaa cgatcttcag gtatatcaaa ggtaacgcct 18420 tggaatagac ctcctcgcat tggattttct agctcgacga gtatagaggc agaaaaaaaa 18480 attttggatg atttaaagaa gcaatacaat tttgctagta atcagctaaa cgaggccaaa 18540 atcgagcaag ctaaatttaa aagagatgaa caactgttag tcgagaaaat agaagggata 18600 aaaaagagga tccttttgaa acgtagggag gtaaactcac ttgaatccca ggaactttct 18660 gtgctagata ccgagaagat tcaaaccctt gaaaggcgca tttctgagac tgaaaaagag 18720 ctcgaaagtt atgcaggaca gttgcaggac gcaaaaaatg aagaacatcg aataagggac 18780 aatcaacgcc cggtaattga ggaaatcaga atttataggg agaagataca aacagagacg 18840 caaaggctct catccttgca aaccgaactc agtcggctac gtgatgagaa aaggaattct 18900 gaagtggata ttgaaaggca tcgacagacg gttgaatcct gtaccaatat tttgcgtgaa 18960 aaggaagcta agaaagttca gtgtgctcag gttgtggctg attacacagc aaaggctaat 19020 actcgctgtg aaagggttcc tgtacagctt agtccggctg agctcgataa cgaaattgaa 19080 agactgcaaa tgcaaatagc tgaatggaga aatcgcacag gtgtttcggt ggaacaagcg 19140 gctgaagact atttaaatgc aaaggaaaaa catgaccaag ccaaagtttt agttgctaga 19200 ctcacgcaac tattgcaagc tttagaagag acgttacgaa ggcgtaatga aatgtggacc 19260 aaatttcgca agctaattac tctgcgaacg aaagaacttt ttgaattata cctcagccag 19320 agaaatttta ctggaaaact ggtaattaaa caccaagagg agtttttgga acctagagtt 19380 tacccggcga atcgtaattt agcaaccgct cacaatcgcc atgagaagtc taaagtcagc 19440 gttcaaggat tatcaggggg tgaaaaatct tttgcaacga tttgtatgct gttgtcaatt 19500 tgggaggcaa tgagttgtcc gctccgctgt cttgatgaat ttgatgtgtt tatggacgct 19560 gttaatagac tagtcagtat taaaatgatg gtagattctg caaaggattc ttcagataag 19620 caatttattt ttattacacc tcaggacatg ggtcaaattg gtttggacaa agacgttgtt 19680 gtttttcgtc ttagcgatcc tgtcgtttcc tcttcagcac ttcctccctc tacggcgcca 19740 tgacatttct actattttga tagtctattg tataggtatt tagaatttat ttattagata 19800 tatagcaagt tcatttgtat attaaatttg actacgaata cgcatttgtc ggccatatcg 19860 tatacttagc agaaagcgag aaatcttagt gtatttgttg ttaccgaaag tcatgctact 19920 tatcggtaga ataaggatgg atcgaatatt caattagcag agtatatggt agggtagggt 19980 tgtgtgactg gtcttagtag aacaacataa ccgaaaaact gacattccta gtgtcaactc 20040 accgcaggac atcaaaatgc caactcacgt atctaagact cgtaagcttc gtggacacgt 20100 ttcagctggt cacggtcgta ttggcaagca caggaagcat cccggtggtc gtggtaaggc 20160 tggtggttta caacacctcc gtagtcactt cgataagtac catcctggtt actttggtaa 20220 ggtcggtatg cgccgtttcc acctcatgaa gaatccctta tggcgtccca ctgtcaactt 20280 ggaccgtctc tggactttac tccccaacga ggctcgtgac aagtatttgg gcaagaacac 20340 tgaggttgct cccgtcatca atgtccttca atccggttat ggcaaagttt tgggtaaggg 20400 acgtcttcct gagacccctg tcattgttca aactcgctac gtttctcgca gagctgagga 20460 aaagattaag caagccggcg gtgttgttga gctcattgca taaacaaata acaataaaaa 20520 gtacattgag cggttaatta ttgtaggggc gtcttttgat tttgaaagta atgtatgtag 20580 ttttgttgaa atccattgat gcacttgaat agagtttatt caagcttcta tcatgttttt 20640 tgataaacat tctatagcgt agcgatttat aagtatattg acatgtttac cctgtaacct 20700 acttattgaa ttttcctcaa ttgaccaaac ttgtttgcaa aagcaatata ttagtttttg 20760 ttgggactgg gtgaatttaa ttttgagtag tgatattatt gtcaaagttg aatatcaaga 20820 aagtctgtta taaagtcttt aaaaaggtca ttattcaatg taatttgttg atgtgccata 20880 tgttgttgat aaataggtaa agatagcata actactactt tttactacta cgaagaagct 20940 attcagctat atctacgtaa aatcgtcatg gtaaagaata attaaatagt ttttaataga 21000 ggagaatttt cgttagagca ttggtgtttt ttttttggaa tcattcttta atttcagaga 21060 gaattggcgt ctgtaacact ttcatctaca cttgaccaaa tattttagtt tcctgggcta 21120 acaagacttc caaagatgga tcaagaacgt aaactgcaat ttttgttatc aatagcggca 21180 gagacatacg cgattagtcc atcattgtca agccactact tgaggaggat gttctctctt 21240 ttggaggaat ggaatttgga aacagatcca aagacacttt tgcacgggtg ttccaaatgt 21300 ggatctttgt ttatatttgg ccgtaatata aaacttcgta caattagttc agagaggaag 21360 gcacggacag atttgaagaa aggagaggtc tcaaggttgg gcacaaattt agaaattaac 21420 tgcttagtct gctcttatgt tcatgaaatt cctttagggg tacctcttcg cttgcaccaa 21480 agcaaacaag cgttacgtgc taaagctatt gctgaatctt catctacgaa actcgaaagt 21540 cgaaaatctg cccataatgc caaagtaaaa caaagacaac gtttgagagc ctccggactt 21600 aatggaattt tggataggaa gaaaaaaaaa gatgaggttg caaaaagcac atcttcatta 21660 agtttacaag actttatgtc accgatatga gtgattctga ttgatctatc aattttctat 21720 ctagttgtca tattcttata cacatatttt ccctctaaaa tgaggattga aacttttctg 21780 acatttatta cagccttcag cgccgtgtac ttcttcctct tttagttcag ctcatttgtc 21840 ttaatgtagt tttgatttaa aatttgaact tcccgtttta gatttgatcg ttaccttttc 21900 ccgttgttta cttttattta catttgtatt agaactattc gtttgggttg gacgagttta 21960 gacaaggggc cccttcttct atttgtattt acttttaact tatttattta ctatttcttt 22020 gatttgtcac ttgtatggtg cgaaatatat acggaaatgt caatcacaga atagcaaaca 22080 aatcgtcaac ttgcggttat tgtgcgtagc atattttcag tagttttctt ttgacaacgc 22140 ccttatgagc atatttttaa gtttccgatt aatcgttcat tcctttacaa gagaggtctc 22200 tcactgtcta ccacctgaag ttgagcttgt gtcaattacc aactccagtt ttgcattctg 22260 aggatgagta atagaattgg gcctcagaga tccacaaaaa ctgcagcgaa gcttcggctt 22320 cttccttcta cagaagaatt tgatgatttt agaaggcagg atacggggcg cgaagtgtac 22380 tcccaaattc ctcaaataga agggtcaacg gcaaaacgag acgcagagca tcttggaaaa 22440 cggcatcgag aattcttacc aagagtaact gcctattgta catgcgatac atttagagtc 22500 gacttgctgt ttaagttttt tcaatctcga agaagtagtc ataaaacaag acctaaacaa 22560 tttgacgaat ggttagttaa tatttttgca tttttctcat tctattgatc cttattgata 22620 tttacttgaa gaggtttatc taacattata acagtattta tagtccgtat agctacaata 22680 atgaagagac gacagactta cttcctgaca cattggagtc ctcccgtgga acgttaaatc 22740 gagaatcttc tcaagaaagt ctacaaagta tttttgaaga atccgggttg gacaggaatc 22800 aacccttgtt tcgggaagtg ttttgcttta cttatggcgt tgttgtttta tggggataca 22860 caattgatga agagcatcgt ttcttaagag aactcggtcg ctttgaaatt gaaaaattaa 22920 gtatgcaaat tactttgggt gacagtcatt atcatattgt tgtatcttta agcagttatt 22980 aacatttgta atttttagag 23000 //