ID SPCC594 standard; DNA; FUN; 16630 BP. XX AC AL031523; XX SV AL031523.1 XX DT 08-SEP-1998 (Rel. 56, Created) DT 19-DEC-2001 (Rel. 70, Last updated, Version 3) XX DE S.pombe chromosome III cosmid c594. XX KW coiled-coil; phd finger; transcriptional regulatory protein. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-16630 RA Rieger M., Lyne M., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (07-SEP-1998) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk and Biotechnologische und molekularbiologische RL Forschung, Angelhofweg 39, D-69259 Wilhelmsfeld, Germany XX DR GOA; O74508; O74508. DR GOA; O74509; O74509. DR SPTREMBL; O74504; O74504. DR SPTREMBL; O74505; O74505. DR SPTREMBL; O74506; O74506. DR SPTREMBL; O74507; O74507. DR SPTREMBL; O74508; O74508. DR SPTREMBL; O74509; O74509. DR SPTREMBL; O74510; O74510. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c594 is overlapped by cosmid SPCC736, EM:AL023705 CC and at its 3' end by cosmid SPCC1682, EM:AL031525. XX FH Key Location/Qualifiers FH FT source 1..16630 FT /chromosome="III" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c594" FT /map="IIIL" FT misc_feature 1..834 FT /note="nominal overlap with cosmid SPCC736, EM:AL023705 S. FT pombe chromosome 3" FT CDS join(1..20,120..210,533..2516) FT /codon_start=2 FT /db_xref="SPTREMBL:O74504" FT /note="SPCC594.01, len:>697" FT /partial FT /gene="SPCC594.01" FT /gene="SPCC736.16" FT /product="hypothetical protein; sequence orphan" FT /protein_id="CAA20660.1" FT /translation="ISTFPESAFRAGMRIAKYIDPAVYYDKYARSPYIMSPFVACVNTL FT SAWPAPSRLEDAVISLVEADSQESDTESLPEINDSSDVSLSDLPSTNVTPKKTTTQIDV FT QTNIVTPPITVTAVPDSPNPPAATPATVADNDDLSIVSSDSGNTTAPRKNRHRYWSFAG FT FSDSTRFSHLNVPAAIPDAPSVKTETSQNVSQLSVKSAATSLAPVEDDEDDELLLHRHI FT TNKHKDFNLHVKQLGLLHKPSLDLEEGYIMDENYGKDVYKHGISNVPDDENEDDLQRYF FT TALEMQQDQKEQHKKSKNKDPFRKITHPSLHLGKFSTPKLIKRMSLRSKKSLRNDSKSD FT DVGNSTHRFSTASAASTSAVKTEKEKKMSAPRRSLDKLIRIGSLHRHHHHHHKTDLIES FT DSGIEASESNRRKSDIFSFSGRNSFSVSRPSSSHSTLSYANDSASSAVNVAGETGSLPP FT LREQTSITSGVPPSNRLKKHVSTPEKIVEERSIDEVSQSNTPSSKQLPQSVDGKTVTAN FT ANSTTVAKQPTSNVALTRPKPVRTATSQSKIPKPVKHIPSDSNNLDPQLGPWRFANPKV FT DPIEDNSFIFGEHKSVKERRKYFSSSKFCRENFFYDKDVVYCMSFFSPHMDFNTFNLNI FT GPIRLNVYKHLNSDGHQPIRYMMRETDDEDAVMFVVEFDLLEDDDETVLAEQAKERERR FT KQT" FT misc_feature 21..26 FT /note="gtaagt, splice donor sequence" FT misc_feature 102..119 FT /note="ctaattccttttcactag, splice branch and acceptor" FT misc_feature 211..216 FT /note="gtaagt, splice donor sequence" FT misc_feature 516..532 FT /note="ttaaccttttgacttag, splice branch and acceptor" FT CDS complement(3528..4997) FT /db_xref="SPTREMBL:O74505" FT /note="SPCC594.02c, len:489, LOW SIMILARITY:Saccharomyces FT cerevisiae, YHC6_YEAST, hypothetical 30.7 kD protein in FT rim1-snf6 intergenic region ., (268 aa), fasta scores: opt: FT 220, E():2.8e-06, (31.8% identity in 132 aa)" FT /gene="SPCC594.02c" FT /product="hypothetical protein; similar to S. cerevisiae FT YHL026C which has has potential signal sequence and 2 FT potential transmembrane helices" FT /protein_id="CAA20661.1" FT /translation="MAPAVFTSDYWKKYFSNKKKPTVKNTSDIDLLHINRGRQPFDEGL FT SINEDSFFYRHNIHVPRIVYLIIVACGSFIITGGIEFAIAYGMYKKTETSVRLWRLPDT FT LSGDAAVTNFVQAIVTYWVESILVQGDLRSGLVKPIYFGWWPENFLLREVLRAKPRYHF FT KFIVFRWMEWLVFVGLRGLVWSVPLWFLFWPATVGILCAPGRHEGNDYYFNNYPAPQVF FT KLIFGGGEGFVLTPWIAFLHMYMYGHYLHVAKNQKSLPKTSDLEQQRGTSSSQPSENDA FT NITALPKPEPKMYENSDLTPARTPVTPAPLEKPVNLAPEVVEPTNAAASPLQLNAPKLT FT DVDDSALAYDPTKVQDGEDRFVHNDVPLENAENPSRFVHSDAPIDMTHTTTVISEAQNL FT PSTLLPQDGNAVHHDTDAPSLSNVRKSVDSPRVPPSFSDDAVSSFSLVTAPSINNVGGS FT TAPSVNNQEREYDYDDTSSRSSTLTERPVVH" FT CDS 6620..6946 FT /db_xref="SPTREMBL:O74506" FT /note="SPCC594.03, len:108" FT /gene="SPCC594.03" FT /product="very hypothetical protein" FT /protein_id="CAA20662.1" FT /translation="MWVTCHLLKREKDEMKKKWREWAKEVCQFGKRILCISITDAALVN FT LEVLEPKNFEPGTLDGAGLFGCWSANGLGIALAYEITNSRFEINSGYTVKVKCLKRFQG FT EARG" FT CDS complement(7963..8979) FT /db_xref="SPTREMBL:O74507" FT /note="SPCC594.04c, len:338, SIMILARITY:Arabidopsis FT thaliana, O81042, f19d11.17 protein, (333 aa), fasta FT scores: opt: 250, E():2.5e-10, (27.0% identity in 319 aa)" FT /gene="SPCC594.04c" FT /product="hypothetical protein; low similarity to a region FT of yeast Farnesyl cysteine:carboxyl methyltransferase; FT conserved residues G{VL}{FW}.{WY}SRHPN{FY}{FL}{GA}{E}" FT /protein_id="CAA20663.1" FT /translation="MPIIYSASDAAKWKVAVSPYLYQLSNLKLLFTGKLNFADFYYNTN FT PFVVGLLLSFILGNVLWGVSVWTKNTSQVDRLWPILPTAFSLHFLFYGLGYNIASRRLM FT IMAFLQTLWSARLTYNYYRKGGYNRGAEDYRWVRVRQIMPKWIYPLFHYFYIHIFQVLH FT LYLLASPTYIAMLAGNERAFGAWDWIALELFMFMFVLEMLADQQQWDYYEARNHYNVDK FT TVPPRFKYDLLSLGRGFNATGLFRWSRHPNFLAEQLIWLSFYLFGAIASESLLNWTIFA FT WLGLVGVFQGSTRLTEKMSCEKYPLYRVYQDKVGRFFPRLDGSHWDIVDDDASLKED" FT CDS complement(9468..10742) FT /db_xref="GOA:O74508" FT /db_xref="SPTREMBL:O74508" FT /note="SPCC594.05c, len:424, SIMILARITY to N-term FT of:Saccharomyces cerevisiae, Q03012, lpi8p., (353 aa), FT fasta scores: opt: 261, E():4.2e-09, (39.8% identity in 133 FT aa)" FT /gene="SPCC594.05c" FT /product="PHD finger protein" FT /protein_id="CAA20664.1" FT /translation="MELTQENTEENEKTHVESIVKFEDSNRGTITDFHIETANNEEEKD FT ANVILNKSVKMEVEEVNGHVDSSSTETDIEMQVIQQPTIPKKPPVSAHRRGPRKHRGNA FT NSQLNLSTADHQRPLYCICQKPDDGSWMLGCDGCEDWFHGTCVNIPESYNDLTVQYFCP FT KCTEEGKGITTWKRKCRLRECSNPTRPNSNYCSDKHGVDFFREKVKLSTVEPSAIKNLV FT LFAKKREEFQNLGTVGPTLPSQVPPEVVYNFEIEEANRLNAEIVQLNKEKEVASNKKIF FT LQLIKDSSRRAVLAYKEREGIKKDLCGFDSRLLFNQQQMNELWEKVSNGAPLSLDMSID FT PSPESTCFTEKRRCAKHTSWQVIFTEDFELQESNILQKLNMKQTAKDVMLEHQKQRCLP FT GIQYDGYARFCHEQLSPEKMANLLK" FT misc_feature complement(10239..10391) FT /note="Pfam match to entry PF00628 PHD, PHD-finger" FT CDS join(complement(12218..12253),complement(11192..12181)) FT /db_xref="GOA:O74509" FT /db_xref="SPTREMBL:O74509" FT /note="SPCC594.06c, len:341, predicted to contain FT coiled-coil region" FT /gene="SPCC594.06c" FT /product="hypothetical coiled-coil protein; sequence FT orphan" FT /protein_id="CAA20665.1" FT /translation="MALKIKIPETSQSSDEYSRWTVYHIEVAFPNGGKHVVFRRFNEFV FT ALDAQIRPNDYNSRLCKLPSKSWVSSTVTNEKLRESRRLALQAYVQCLSETPWIKMPVV FT KKFLNIKDESEDETQGQFLGPTDWIQVFQDCKRNLHMYRVDLMSGKSITIGVQTKNVYA FT IKSLMDNLSESLDKLELANALGPGEILRRKDMLEQLGSEFLSFKRLVKNANSPVAPPSA FT SSQLNSSNPSSPFRPLSASTDKQSNTSLNRVLGKNRMPETQTTKKLDNVGLYNMQNQTM FT EDQDMQAESLLPIIQRQKELSKMINQEVVEQNSMLDELSNEAYANQKKLHRTRAGLRKL FT G" FT misc_feature complement(12182..12202) FT /note="ttaatttttacttacaactag, splice branch and acceptor" FT misc_feature complement(12212..12217) FT /note="gtaagc, splice donor sequence" FT misc_feature complement(12678..12733) FT /note="hit to Schizosaccharomyces pombe cDNA, clone spc0204 FT 5 but only short" FT CDS join(complement(14104..14259),complement(13443..14054)) FT /db_xref="SPTREMBL:O74510" FT /note="SPCC594.07c, len:255" FT /gene="SPCC594.07c" FT /product="hypothetical protein; contains 8 predicted FT transmembrane helices; contains a predicted N term signal FT sequence; sequence orphan" FT /protein_id="CAA20666.1" FT /translation="MSGSKCCSSSNTIKVSIYLFLHTLTYGLLNYHLNPRLLASTGVVE FT SDIPYWMSYLSIIMHVGQSLLLQKFNLGYGWLLLTKYPVYVLLSTYYLTPLSQIAWAFI FT IDAISLLVARCFSRANPIKCSNQVNTQYSVSFLFTIMASVLISVLNYISQKIFLNGLIL FT GNSHNVVTSLVAPPLPLQYLAHVPIGYVIQRVVFSERPIPQSLFLMIFLTLWNCFIPYS FT ILFSMNWSAMFQVVGAYLSQIWIITFICWALSL" FT misc_feature complement(14055..14072) FT /note="ctaacaatggattgaaag, splice branch and acceptor" FT misc_feature complement(14098..14103) FT /note="gtatgc, splice donor sequence" FT misc_feature 14693..16630 FT /note="nominal overlap with cosmid SPCC1682, EM:AL031525 S. FT pombe chromosome 3" FT misc_feature 16494..16630 FT /note="SPCC1682.01, see c1682 for full length CDS" XX SQ Sequence 16630 BP; 5682 A; 3004 C; 2993 G; 4951 T; 0 other; gatctctacc ttcccagaaa gtaagttttt taaaagcata ttctttagtt ttcttcttcg 60 ttttatctca tttcgtcttt ttttttccgc ggtgcttaat gctaattcct tttcactagg 120 tgctttccga gctggtatgc ggattgccaa atatattgac cctgctgtgt attatgataa 180 atatgccaga tccccgtata tcatgtcacc gtaagtattg atgctcgtct gttggatatg 240 cataatagaa agggtcgaaa atttttacaa tctgggcatt gcctgaaaac aaaggtttat 300 tgaaaacaaa agaccgaatt taggcatctt gattattcgc tttctttctt tctttttttt 360 atttttctta taatttttta atcaccccat cggtttgctt ccactacctc ttgagttcct 420 gattcaaatc atatagtctt tttgttttct ggccttatcg attgcaaggt tttccattat 480 cctctcagat tatctttttt tttaaaacac gatttttaac cttttgactt agattcgtcg 540 cttgtgtgaa tacactctct gcatggccgg ctccatcgcg tcttgaagat gctgttattt 600 cattagtgga agctgattct caggaatcag acactgaatc gttacctgaa attaacgact 660 cctcggatgt cagtttatca gaccttccct ctaccaacgt tactcccaag aaaaccacga 720 cacaaataga tgttcaaaca aatattgtta ctccgccaat tactgttaca gcagtacccg 780 actctccaaa tccccctgct gctacccccg ctaccgttgc agataatgat gatcttagta 840 tagtatcctc tgattctgga aataccactg cacctcgaaa aaatagacac cggtattgga 900 gttttgctgg atttagcgat agcacacggt tttcacattt aaacgttccg gctgcaatac 960 cggatgctcc atcagttaag actgaaactt cccaaaacgt gtctcaatta tctgtaaaat 1020 ctgcagctac ttctctagct cctgtggagg atgatgaaga cgatgagctt ttattacatc 1080 gtcacattac caataaacat aaggatttta atttacatgt caagcagcta ggattgcttc 1140 acaaacctag tttggacctg gaagagggtt atataatgga tgagaattat ggaaaggacg 1200 tgtacaagca tggtatttcc aatgttcctg atgacgaaaa tgaagatgac ttgcaacgtt 1260 actttactgc tttagaaatg caacaggatc aaaaggaaca gcataagaaa tctaaaaaca 1320 aagacccgtt tcgtaaaatt acacatcctt ctttacatct tggaaaattt tccacgccca 1380 aactaataaa acgtatgtcc cttcgctcaa aaaaaagttt aagaaacgat tcgaaatcgg 1440 atgacgtcgg taattctact catcgatttt ctaccgctag tgcagcatcc acgtctgctg 1500 taaaaactga aaaagaaaag aaaatgtcgg cgccacgtcg ctctcttgat aaattaattc 1560 gcataggttc tttacaccgt caccatcatc atcatcacaa aaccgaccta attgaatctg 1620 actctggaat tgaagccagt gaaagtaacc gtcgtaaatc tgacattttt tctttttctg 1680 gaagaaactc attttccgtt tctcgtcctt cctcttctca ttccacgttg tcatatgcca 1740 atgattcagc atcatctgct gttaacgtgg ctggagagac tgggtcgtta cctccgctac 1800 gtgaacaaac atctataacc agcggtgtcc caccttctaa taggcttaaa aaacacgttt 1860 caacacctga aaagattgtt gaggagcgat cgattgatga agtatcacaa tctaatactc 1920 cttcttcaaa acaattgcct caatctgttg acggaaagac tgttaccgcg aatgctaata 1980 gtaccaccgt cgcaaagcaa cccacgtcta atgtggcgtt gacgaggcca aagcccgtgc 2040 ggacggctac tagtcaatca aaaataccga aacctgttaa acacatccct tctgattcaa 2100 ataatctcga tccacaactt ggaccttgga gattcgccaa tcccaaagtg gatcctatag 2160 aagacaattc gtttattttt ggtgaacaca agtcagtaaa ggaaagacga aagtactttt 2220 caagctccaa attttgtcga gaaaatttct tttacgataa agatgtagtt tattgcatga 2280 gtttcttttc ccctcatatg gattttaata cctttaattt gaatatcgga cccattcggc 2340 tcaatgttta taagcatttg aactctgatg gtcatcagcc aatccgatat atgatgcgtg 2400 aaaccgatga tgaagatgct gttatgtttg ttgtcgagtt tgacctcctc gaagatgatg 2460 atgagacagt tcttgccgag caggctaagg agcgtgaaag aagaaaacaa acttaacgat 2520 tatttaggcc tgttttttgt tctttagact ttaatggcgg tttgtcttgt atcgtcgaat 2580 actgctcttt tttgtgctct ctataatgac tttatgtttc ggtacgcgac actctctttt 2640 aactgtataa atggaaatta gagattatgt tgccgtaaat aaaatatgaa atgagttcga 2700 ctagccattt aattattatc ctggaaggtt ttctttacat ggtaaatgat ttcgcttatc 2760 tttttttaat agcaggtgtt cagtgtcaat atttacgttc catccttccg aagctatcat 2820 cgttcctttt atatggccta gtcggctttc taatgcattt ttgtttatat gcttctttca 2880 atactttatc tgtgtttgtt cttatggacc cattagacat catttttttt aatatgattt 2940 gctgtaagtc ggctttttgt cttttttctc ttacctatac atgtataacc tttataaatg 3000 attgtagtta attaattcga ccttactctt tctttcattt tctttttttg aaagtaagta 3060 gtacaacttc atttaccatt tgcaaatcta cgtggtatat aatacatatc tactgacttg 3120 cgtgtaaaat gagcaaaatt gtctttacat agctacgcag tcgctacaga acaatgtttt 3180 ttgacataca ctatagatgc agactaaaaa attttagcag aaaacaaatt cagataaacc 3240 taaagttatg taagttactg tcaaaatttt taaaagttca gttaagatta ttccttttcc 3300 ctaatttatg ttttgttaaa actctatgtt tgatgcattt aaaacaagaa gcctattgaa 3360 cagcgaaata ttaagttaat tgaaacatta aaacatgaaa gatgctgttt ccaacggatc 3420 ttaaaaacac gattatacta aagagatcag cagaaatagt tgccacgaga caatagggaa 3480 cattttccga cttaatatca cagcctttat aattcacaat atttcagtta atgaactacc 3540 ggtctttcgg tgagtgtgct gctacgagac gatgtatcgt cataatcata ctcccgctcc 3600 tggttattca cactaggtgc agtagaacca ccaacattat ttatactggg ggccgtcact 3660 aacgaaaatg acgagacggc atcgtcacta aagcttggag ggaccctggg tgagtcaaca 3720 gacttcctga cgtttgaaag agatggtgca tcagtatcat gatgtacagc attgccgtcc 3780 tgtggaagca acgtggaagg caaattttga gcttcagaaa taactgtagt agtatgtgtc 3840 atatcaatgg gagcatcgct atggacaaat cgactaggat tttcagcatt ctctaagggc 3900 acatcattat gaacaaaacg atcttcacca tcttgaactt tagtggggtc gtatgcaagg 3960 gcagaatcat caacatcagt taatttaggg gcgttcaatt gcagagggga agcggcagca 4020 ttagtaggtt cgacaacttc cggtgcaaga ttgacgggtt tctcaagagg tgctggtgtt 4080 acaggcgtgc gagcgggtgt taagtccgag ttttcgtaca tctttggttc aggcttaggg 4140 agggcagtaa tattagcgtc gttttctgaa ggctgtgaag aagaagttcc tcgttgttgt 4200 tctaagtcgg acgttttagg aagtgatttt tgattcttgg cgacatgaag gtagtgacca 4260 tacatataca tatgtaaaaa tgcgatccat ggtgtcaaaa cgaaaccttc accaccacca 4320 aaaatcagct tgaacacttg aggtgccgga taattattaa aataataatc attgccttca 4380 tgtctaccag gagcgcaaag gataccgacg gtggctggcc aaaacaggaa ccataaggga 4440 actgaccata ctaagccgcg taatccgaca aagacgagcc actccatcca gcgaaaaaca 4500 ataaacttaa agtggtatct aggcttggca cgaagcactt ccctaagcaa aaagttttcc 4560 ggccaccacc caaagtaaat aggctttaca agtccggaac gtaaatcacc ctgtaccaaa 4620 attgactcaa cccagtacgt gacaatagct tgaacgaaat tggttacagc ggcatcacca 4680 gagagtgtat cgggaagacg ccaaagacgg acggaagtct cggtcttctt atacatacca 4740 tatgcaatgg caaactcaat acctcccgtg ataataaagg aaccacatgc aacaatgatt 4800 aaataaacta tacgaggaac atgaatgtta tgtctgtaaa agaaagaatc ttcattgatg 4860 gataatccct catcaaaagg ctgacgacca cgattaatgt gaagcaaatc aatgtccgaa 4920 gtattcttaa cagtaggctt ctttttgttg gaaaagtatt tcttccagta gtcggaagta 4980 aagacggcag gcgccattcg gaggaaatta gtgacgaatt acttacttcc ggtgaatatt 5040 aagtaaacag caggcaacga gatcgtaaag aacagatatg ttttaaacga caagaataag 5100 ttgaagatcg aatgaacaca acttgggaag ataaaaaatc acgtaaatag aagttaattt 5160 tgcggaatat cttcaattaa cagacacaga tggtccggtt ttgtttgaga tagatgcaga 5220 tgaaattaaa taaaaagtaa attttcagta atagcaaaaa aattttgagg atatttttgc 5280 ctttggtaaa aaaaagaatg atatacagtg agaaatgaaa atttttcaag ttttcataca 5340 cgtatgtacg ttcttccaat attaagaaag cgaaacagaa aatgtcgttt taaaatggat 5400 taaatcgaac agattactaa gaaactgatg tgggcttatt tttccaatag aaaaagcaag 5460 acaaaacgac cgggttttcc tctgtttgaa aaaaatttct tctcgatcaa actatacgga 5520 gaaaacgaaa gaagccgagt acgagatgat taagacagct gcagagttag atgataaaaa 5580 gattgcaaca aatcgcacac agtaataaca gggcttgaag gtagaagaaa ttggttatag 5640 caacccgaaa aaaaaagcgg aataacgatc acacggcaca caatagaacg aaattatagg 5700 ggagcaaagc agagtagggc aaagcaaatc acgtaaatac gtcgacaaat attattataa 5760 agtgtaaaaa agatttaaca atattgagaa gacagatgtg caggcatata aacgagaaag 5820 gcgaaagaaa aaagaattag ttcgtaaaat caatcaatag aaagactttt tttcgaacaa 5880 gtattatatt gctcacaaaa tcaaacgttc aaacaagaac aagggaaatt aacagaaaac 5940 gaaaacaaac agataataaa ttaattaaaa aatagtaagt gtgaaggggt agagtaggtt 6000 tttgtacaca gacgttccca aaccaccgtt ctccaataaa aatccaagga taaaaaaatt 6060 gcaaatgaag ccggaacgga ttctacaaac agatgaagaa gagaaaacaa cttcaacagt 6120 gtaaacgata ggaaataaac cttatggaag aacttggtac gccaaagcaa actatatgaa 6180 gcctcagtcc gcttctttta cactcaggta taatccgtaa acaagtcgca aaacgctccg 6240 aaaaaaaact tcagaggaag caaacttcaa cagaattaaa gaaccaccca aatcacctga 6300 aagctttcag tttccacgtc taaacgacaa attttcgaaa tttaaaacga caagtccctt 6360 gttgtgtgtt tgggggacgg atgaagcgta agcacatgct acgttatgtt ttcttcatga 6420 tcccatactc aaactcggca atgactgtcc tgtgatgtca taaataacga ttttgttcgt 6480 agtatataat accctaccgt aatgtaccgc tctcatctcc cggagtgcgt tatttcctga 6540 cctcgtgccc cagacaacca tcgctcggaa gcgtcagggg tcttgaacga gtccacgtaa 6600 ccgagccggg gcatcctcca tgtgggtaac gtgtcacctg ctcaagagag agaaagacga 6660 gatgaagaaa aaatggagag aatgggcaaa ggaggtatgc caatttggaa agcgaatttt 6720 gtgcatttca attactgatg cggcactcgt aaacctagag gtccttgagc caaaaaattt 6780 tgagcctggg acgctagacg gagcgggttt gttcgggtgt tggtcagcta acgggttggg 6840 aattgcattg gcatatgaaa ttaccaatag tagatttgag atcaactcgg gatatacagt 6900 taaagtgaag tgtttaaaga gatttcaagg tgaggcgaga ggctagaatg ctcatgcaga 6960 gcatgcaccc acgatcgtac catagaaggg tgacagatgg aggataaacc aaggaaaaaa 7020 aaagtttaat agaagaaaca acgtttaatg tttttaaatt gcatgagaca aagcaatgtt 7080 ctcaaatcaa caaggcatct tctaagccag gctgcaaatg tgtaatggac caatggaaaa 7140 attcttactc acatgagtaa acgtataaaa ctaaccctcc gtgtgaatgg taaaccatgt 7200 tacacagata aagcagccaa gataacagag aaggaattgt actgtgtgtg tgagaaaata 7260 ttcacatgat aggtggtgct taggaaccaa gcaactggcg gatgcacaga agaaaatggt 7320 agagaaaaat gtcagaaaaa caaagacaaa tgaaaaaaag aaaataataa taaacacttg 7380 aatgaattta cggatgtacg ttccagtgaa tgaatgagtt tacggaaaag aattgggttg 7440 gtttcgcctc ccttttccct ccctcttttt ctccacagtg aaaagataag attttaaaaa 7500 aatttaacat tcagtttaag gaagcaaaca cttttgatag atggtttgaa ggccgcacat 7560 agtttgaaga caaagagacg aagttcagtt gagtttgaga tttcataaaa tggattgttt 7620 caaaaaataa aaacaaattt ttttttctgt tctgtgtcct aatagacatt agcaatacta 7680 taaacaaagc caccacatat tataacatgg atgaagaatt cacaaatcag catggaaaaa 7740 aattcacgga tcagttgcat aaataaagct tgcataactc atcgacaaaa cattggataa 7800 atagactaag atagatacac aagataataa tacataaata aattacagtg aaccaaattt 7860 tagagagggg gtaaaacgtc aaaaggtttt gttacaccaa ttgacaaatg aaaatgaaac 7920 gagatccatg gatcactaat agaggaacat tttgtttctc cattaatcct cctttaatga 7980 tgcatcgtca tccacaatat cccaatgact accatctaat cgaggaaaaa agcggccgac 8040 tttatcttga tacactcgat ataacggata tttttcacag gacatctttt cggtaagtct 8100 ggtcgagcct tgaaaaacgc ccactagtcc aagccatgca aaaatcgtcc aattcaatag 8160 tgattctgaa gcgatcgctc caaatagata aaatgaaagc caaataagtt gttctgctaa 8220 aaagttggga tggcgactcc atcggaagag ccctgtagca ttgaaaccac gtccaagcga 8280 caacaagtca tacttaaacc gaggtggcac ggttttgtcg acattgtaat gatttcgcgc 8340 ttcatagtaa tcccattgct gttggtcggc tagcatttct agcacaaaca taaacatgaa 8400 aagctcgagt gctatccaat cccatgctcc aaatgctcgt tcgtttccag ccaacatggc 8460 aatatacgtg ggagatgcaa gcaaatatag gtggagcact tgaaagatat gaatgtaaaa 8520 atagtggaat aatggatata tccatttagg catgatttgg cgaactctca cccaacgata 8580 gtcctctgct cctcgattat aacctccttt acggtaataa ttgtaagtaa gacgcgcgga 8640 ccatagagtc tgcaaaaatg ccataatcat taatcttcgc gaagcaatgt tgtatcccaa 8700 accataaaac agaaaatgca aggaaaaagc cgttggcaga attggccata gccgatccac 8760 ttgcgatgta tttttcgtcc aaacagacac tccccaaagc acatttccca aaataaatga 8820 gagaagtagt cctacaacaa atggattcgt attataataa aaatctgcaa aattcaactt 8880 tccagtaaac agtaacttca aattgctcag ttgatacagg taaggagata ctgcaacttt 8940 ccattttgcg gcatcagatg ccgaataaat aattggcatg gtggatgcca aagtcatagt 9000 gctcgtttga aaaagaacaa tgggaatgtc agaaagttgg ctttctatag ctccacgaaa 9060 tcctctgtct cattgtgacg ttagcttctg gaataagaag gattagtgaa atccaaggag 9120 cctgcgtttt ccaaaaaata aaataaaata aatttcaaaa caaaagagag agaaaacctc 9180 aaggccatta agacatgagt tgataaaaag agagggtgta gaatgtatgt ccttatgtta 9240 aaaagtgact ttttagaagg aaaaaccaaa ttaccatctg tcaacattat tttgcgaaac 9300 agggagtcaa taaatttaaa gccaaaatta agagacaaat gccaagcaat ataaactttt 9360 ctttcattaa catttgcgaa tcaatgcctc gtgatttaca tgaaatgatc tagaaattaa 9420 agcaaacttc aaaattgtaa attaaaccaa aagatgcatc cttctgttta ttttaataaa 9480 ttagccattt tttcgggaga taactgttca tgacaaaatc gagcataacc gtcgtattgt 9540 atcccgggta ggcacctctg tttttgatgc tccaacatta catctttggc agtttgcttc 9600 atgtttagtt tttgtaaaat attactttct tgcaactcaa aatcttcggt aaaaattacc 9660 tgccagcttg tgtgctttgc acatcttcgc ttctctgtaa agcaggtgga ctcaggagaa 9720 ggatctatac tcatgtcaag agatagcggt gctccatttg aaactttttc ccacaattca 9780 ttcatttgtt gttgattgaa taaaagtcga gaatcgaatc cacacagatc tttcttaata 9840 ccttctcttt ctttgtaagc aagaaccgct ctccgcgaag aatctttgat caactgaaga 9900 aatatttttt tgttagatgc tacttctttc tctttattta attgcacaat ttctgcgttc 9960 agcctattgg cctcctcaat ttcaaaattg tacacaactt caggaggaac ttggcttggc 10020 aatgtcggtc ccaccgtacc caaattttga aattcttccc ttttttttgc aaacaataca 10080 agatttttta tagcagaagg ttcaaccgta ctcagcttta ctttttctcg aaaaaaatcg 10140 actccatgtt tatcactaca atagttggaa ttaggtcttg tgggattcga gcattctcgt 10200 aaccggcatt ttcttttcca agtagttata ccctttcctt cttctgtgca tttaggacaa 10260 aagtactgta cagttaaatc attataagat tcaggtatat taacgcaagt gccatgaaac 10320 caatcttcgc aaccatcaca tcctaacatc catgatccat catcaggctt ttggcatata 10380 caatacaatg gtctttgatg atcggctgta gacagattga gttggctatt cgcatttcct 10440 cggtgttttc gtggacccct tctatgagct gatacgggtg gttttttggg tattgtaggc 10500 tgttgaatga cttgcatttc tatgtctgtt tccgttgagg aagaatcaac gtgaccgttg 10560 acttcttcaa cctccatttt aacagattta ttgagaatta cgttggcgtc tttctcttcc 10620 tcattgttag ctgtctcgat atgaaaatca gtaatggtgc ctctattcga atcctcaaat 10680 tttacaattg attctacatg agttttttca ttttcctcag tattctcttg cgttaattcc 10740 attattggaa tttcagttgt ctaagtctgt caataagtaa aatctaaaga aagcgagctt 10800 aagcacagta cactaaatgc attaaaagga actacaagcc aaaccaaaat acaaaagaaa 10860 tggggtctgt caaaacaagt tgaaatttaa acaagtcgta tattaatatc aagcttaatt 10920 aaaggagaca attatttcaa ccttgacgga cgaactaacc atgcctatat aactcacaga 10980 ggttactgcg gtatcttcaa gaagattaaa caaaaaaaaa aaaaaaggaa agaacgcaaa 11040 tacaccaaat aataaatatt tttagcccag ataatctcat ccaagacaat cactaatgta 11100 gcagaattgg atagaaaaca agacaaaact gcaaaagaag attccattaa atttcgtgaa 11160 attaaatcaa atactcataa acacccaaat attaacccaa tttgcgaagg ccagctcgtg 11220 ttctgtgtag ctttttttgg tttgcatatg cttcattaga aagctcgtct aacatggagt 11280 tttgctcgac aacttcttga ttaatcattt tcgaaagctc cttctgcctt tgaataatag 11340 gcaataacga ttctgcttgc atatcttgat cttccatagt ttgattctgc atgttgtaca 11400 gtcctacatt atcaagcttt tttgttgtct gtgtctctgg cattctgttt tttccaagga 11460 ctctgttcaa agaggtatta gattgtttgt cagtagatgc agataatggg cgaaagggag 11520 aactaggatt agaagagttt aattgagatg aggcagaagg aggagcgact gggctgtttg 11580 catttttaac taaccgttta aatgacaaga attcagaacc aagctgttct aacatatctt 11640 ttcgtcgaag gatttctcct ggaccaagag catttgctaa ttctaatttg tctaacgatt 11700 ctgaaaggtt atccattagc gactttattg catagacatt ctttgtttga actcctatcg 11760 taatgctttt tccactcatt aagtcaactc ggtacatatg taaattacgt ttacaatctt 11820 gaaatacttg aatccaatct gtcggaccca aaaactgacc ctgtgtttca tcttccgatt 11880 catctttaat atttagaaat tttttaacca caggcatttt tatccatggc gtttctgaaa 11940 ggcattgaac gtaagcttgt aaagcaagtc gtcgagattc acgtaacttt tcatttgtca 12000 cagttgaaga aacccaagat ttagagggga gtttgcaaag tctactgttg tagtcatttg 12060 gccgaatttg agcatccaaa gcaacgaatt cattgaaccg acgaaataca acatgtttcc 12120 caccattcgg aaatgctact tcaatatggt aaaccgtcca tcgtgaatat tcatcagaag 12180 actagttgta agtaaaaatt aaaggaataa agcttacttg agacgtttct ggtattttaa 12240 tttttagcgc catacttgct atgaacaggt tgatcaacaa tgagttcatg aacaacagac 12300 tactgtatcg gatttactgc actatcgtta taaaactgta taatgtagaa tttgagcttt 12360 caaatagtat aggttctatt agttgaataa agataaattt cagtttcatg atgctttaga 12420 tcctttaaac ctcatgtttt ccttgatgcg cgagatgcct ttacgattat cgaattggca 12480 ggtattgaaa gaaagtttac cagtttgcaa tagatttaga aattaaaata atgaattagg 12540 ttagtatatt atcttatacc tttaaacact ttatagtcag attattgagt attttttttg 12600 gcactcgtga acggtgcaac ttacaagtaa ttacaatacc taaacagaag aacggcaaaa 12660 tcttaacgaa gcttagtaat aaacagaaat tgtttatttt ctatattttc ctacatggat 12720 tggttgcaag cgcgacttgc ctaaagtatt aaaagcacag aataaacgcc agatcgtaac 12780 attatgcaaa agtgtaagta taggtagatt ccaaataaca acagtactct gatatgcata 12840 aagatttttc acttaaaata catgtcatgt aaatataaag gccccacaga tgatatataa 12900 tagtactagt ggaacttaac aactgttttt tcatatcacg agagggaaaa atatacagcg 12960 aaaagacttc tcacatttgc ttaaagtata accatatact gcttttgaac gatcatccaa 13020 ttcaaactat gcgaccctaa tagatgagaa taaaggacga aacatcccac aatggatatc 13080 ttttaaaaga gttcggaatc aatttgaaac cacagtcatt aaattacata tattcatagt 13140 cagttccaca catgatgttc aactcagaaa gaagaaatct gcctccttca tcagaaataa 13200 attccaccgt gaaaacgaaa aatgaaaaag agaagaaaaa gggcattaac ctgatgaaaa 13260 aagtttgacg ttacctcact gaaattattg aacacgagta aagacatata gacaaatttg 13320 gaaaatccca taacagatac aatgaattaa gataagccca tgagaacttc caccaggaag 13380 taaacaacca actaactaca ttacaagaaa aaaaatgatg taaaagaaac agaactcgaa 13440 ctttacagag acaatgccca gcagataaaa gtgataatcc aaatttgtga caagtaagca 13500 cccaccactt ggaacatggc ggaccaattc attgaaaaca aaattgaata aggaataaag 13560 caattccaca gagtaaggaa aatcatcaaa aataatgatt ggggaatagg cctttcacta 13620 aacacgactc tttgaataac gtaaccaatt ggtacatggg caagatattg taacgggagc 13680 ggaggggcaa cgagactagt aacaacgtta tgggagtttc caagaataag accgtttaag 13740 aatatctttt gtgatatata attaagcacg ctgatcaata cactcgccat aattgtgaat 13800 aggaaagaga cactatactg tgtgttgact tggtttgaac atttgatggg gttagctcta 13860 gagaaacagc gcgccactag caaagaaatg gcgtcaatta tgaatgccca agcaatttga 13920 ctcaaaggag taaggtagta ggtcgagaga agcacgtata ctggatattt cgtaagtaaa 13980 agccatccat aacctaggtt gaatttctgc aacagaagag attgaccaac gtgcataata 14040 attgataaat aactctttca atccattgtt agtaaatcta aacttatata atgatctgca 14100 taccatccag taaggaatat cactttccac cacccccgtg gaagctaata atcgtggatt 14160 gaggtgataa tttagcaagc cataagttaa cgtgtgtaaa aataggtaaa tggacacctt 14220 tatggtgttt gaagacgaac agcacttcga tcctgacatt ttgcgaatat tggtagtttt 14280 catatagttt gtcatcgatg aacacacaag taacgattga tcaggtaaca gtatcttcaa 14340 acaatggagt ctgtgaaatg gtaaataatg aatcagcagg aaaccaggat cctttgaatt 14400 taggtagtaa gtctatggaa aaccaaaatt atatttttct tgaaattccg tgttattaaa 14460 tctctaggat tagtttgcaa gaaagtgttc tccgtgcaaa cattagaacc gtgggatttt 14520 aagcataaaa tgggtacaaa atgaaatata aaaacaaaga atgaccgatg cctttattac 14580 catgaataat tatgtgtttt gaattatccc taaaaaaaaa aaacattacc tttattttca 14640 ctttattaaa ataattttaa cttattcatg gagttggttc attaacttaa atgatcgtaa 14700 ataataatcc aaaaaacctt atactgctaa tttactagta cctttttttt tattttattc 14760 ttttttaaaa aagaaaaaag gggaaattag cgacatatat tatggactta aatttttcta 14820 agtacattac tttacgtata tgcaacgatt aaaatcaaac tgaagtaaaa aggtgatttt 14880 ttataattcc taaagtcaaa caaaataatt atttaataac ataaaaacca tgaggtgatt 14940 gacttgagcg gtaatttaat atatcaaata atttatgtta tttcaaatct ctcttccctt 15000 aataatctga taatctatag tcactgagaa cacatatata ataaaaaatg tgctatttca 15060 aaatatttat tccattatag gtagcttcat ttttcatgag agaatcgcca gtgtatattg 15120 aaaattcata aaaataaaaa gctaaatatt tcggacaatt gagacaaaaa aacctataaa 15180 tatatatgta catattaaaa taattttttg aaatttatta gaataatcaa gctcaagctt 15240 ttgcattgaa aagaatttat acataaaaca tgaatgtcta agtataaaaa tttgaattaa 15300 ctagttgctt atatttctac ctttgacata atgttattaa agaaaggaaa taaatacatc 15360 tgaacgaaat aaattataag tttataggta aaatggttat acaaaggtgg aagtactgtt 15420 ggcgtaactt atttttctga agcattaatg caaacaccaa acccgtgcca acattaatac 15480 tccatatctg aaagagataa gttattctat atagtaaaaa gctaaatgat tatcaacaaa 15540 gtcgatacaa ttgctatatc ggattttata ttcactgata ctcaaagaat atcaaaatac 15600 aattactgca ttctttacaa attctggatt tctttttggt ttaaaaagaa ttcattgagg 15660 cgatttgagg attagcagca tatatgtcaa acatttaaaa gtgtaaacaa agtatagaag 15720 agctagcaaa tagcggaaaa aggaacgccc aaaaacttta ttaatattaa atatagaaat 15780 ttcttatgaa atggcaagtt taattcaaat atgccaaaaa tctccttgtt ttaacaatcg 15840 agaaaacaca ggaattcaca aaatagccat gtacttgaaa gtccttcatc gcgaatgtat 15900 tattgcattt aacatatatt gttccaattg tactgccaga caaaccagaa taatattttt 15960 aacaacatag cgtgttcaaa aactcaactt gacttttcat caattaatca ttttttgtcg 16020 aaatcgttac aagtatttga gagagcgtaa tgattacatt acttaaatcc agctgatgat 16080 gtacaaaaga taataattgc ggtttttgaa aatgaaagcg aagtttagaa aagggcttgc 16140 tatgtgcata ctgaatgttt aagcaacata aagacgattc tattcgaaaa ccgtgcagaa 16200 atacaagact tgctgtttcg tttgctagat caatcgatag tcaagattat tttatacatt 16260 aataaatagt aaggtaactg atcaatcaat aaatttaacc aacaaattgt ttctcgccat 16320 gtaatagttt tagaattttt tagatattta ccaaatagtg atacagagcg cgaatcatga 16380 tagtgagttc ttgagaggac taccatatcg ctttcatcga ttacaagcta gttaaatcat 16440 taaattatct tttgcattcg gaacgatctt cctcactatt ccctttcctt ctgatgctat 16500 tcgctcagtt ttcgcattcc attaccaact tactcccctc tctttcaatg gtaagtaaag 16560 ggatatcgag atgttgaaaa caatggtttg gatcgatttt aatcaatttc aattaggcta 16620 gttcaactat 16630 //