ID SPCC364 standard; DNA; FUN; 14999 BP. XX AC AL022243; XX SV AL022243.3 XX DT 25-MAR-1998 (Rel. 55, Created) DT 28-MAR-2000 (Rel. 63, Last updated, Version 6) XX DE S.pombe chromosome III cosmid c364. XX KW nucleosome assembly protein; phosphoglycerate dehydrogenase; KW ribosomal protein; tRNA-Ser; vacuolar sorting protein. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-14999 RA Wood V., Rajandream M.A., Barrell B.G., Murphy L., Harris D.; RT ; RL Submitted (23-MAR-1998) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; O59793; O59793. DR GOA; O59794; O59794. DR GOA; O59796; O59796. DR GOA; O59797; O59797. DR GOA; P87228; P87228. DR SPTREMBL; O59792; O59792. DR SPTREMBL; O59795; O59795. DR SPTREMBL; O59796; O59796. DR SPTREMBL; O59797; O59797. DR SWISS-PROT; O59793; BIS1_SCHPO. DR SWISS-PROT; O59794; RL17_SCHPO. DR SWISS-PROT; P87228; SERA_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPCC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c364 is overlapped by cosmid c4G3 and cosmid c970. XX FH Key Location/Qualifiers FH FT source 1..14999 FT /chromosome="III" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c364" FT /map="III" FT CDS complement(1..245) FT /db_xref="GOA:P87228" FT /db_xref="SWISS-PROT:P87228" FT /label=SPCC364.07 FT /note="SPCC364.07, SIMILARITY:Saccharomyces cerevisiae, FT SERY_YEAST, putative d-3-phosphoglycerate dehydrogenase FT yil074w, (469 aa), fasta scores: opt: 176, E():4e-06, FT (45.3% identity in 75 aa)" FT /partial FT /gene="SPCC364.07" FT /product="putative d-3-phosphoglycerate dehydrogenase" FT /gene="SPCC4G3.01" FT /protein_id="CAA18289.2" FT /translation="MDIKGGRRGNVEDSLNKLSLSPPDNNSSFLSNHFQVRKSYSQAPA FT RTLKPFASEDIKILLLENVNQSALSNLKDEGYQVEF" FT misc_feature complement(1..2151) FT /note="nominal overlap with cosmid SPCC4G3, EM:Z97052 FT S.pombe chromosome 3" FT tRNA complement(1376..1457) FT /label=tRNA-Ser FT /note="tRNA-Ser : anticodon aga" FT /gene="tRNA-Ser" FT /product="tRNA-Ser" FT CDS complement(2567..3748) FT /db_xref="GOA:O59797" FT /db_xref="SPTREMBL:O59797" FT /label=SPCC364.06 FT /note="SPCC364.06, len:393, SIMILARITY:Schizosaccharomyces FT pombe, P78920, nucleosome assembly protein, (379 aa), fasta FT scores: opt: 740, E():0, (43.8% identity in 386 aa)" FT /gene="SPCC364.06" FT /product="nucleosome assembly protein." FT /protein_id="CAA18288.1" FT /translation="MVENVNINNKRAGKMSAAPTPHNTPSGTSAPNFGAKAPQVNTIDE FT GDENLEAIDGKLGSLLHLTSEGVSELPEAVQRRISGLRGLQKRYSDLESQFQKELFELE FT KAYAKKYAPIFKRRSEVVRGADEPTEEEIKKGEAADENEKKEPTSSESKKQEGGDDTKG FT IPEFWLTAMKNVLSLSEMITPEDEGALSHLVDIRISYMEKPGFKLEFEFAENPFFTNKI FT LTKTYYYMEESGPSNVFLYDHAEGDKVDWKENADLTVRTVTKKQRNKNTKQTRVVKVSV FT PRDSFFNFFNPPTPPSEEDEESESPELDELLELDYQIGEDFKEKLIPRAVEWFTGEALA FT LENYDGFSDLDVEEDEDDVESSSNEEVSDSDEEDSDSKHTAHGQQNAAECRQQ" FT misc_feature complement(2732..3523) FT /note="Match to NAP_family Score 410.48" FT CDS join(complement(7090..7165),complement(6977..7041), FT complement(6817..6922),complement(6577..6764), FT complement(4223..6520)) FT /db_xref="GOA:O59796" FT /db_xref="SPTREMBL:O59796" FT /label=SPCC364.05c FT /note="SPCC364.05, len:910, SIMILARITY:Saccharomyces FT cerevisiae, VPS3_YEAST, vacuolar protein sorting-associated FT protein vps3., (1011 aa), fasta scores: opt: 218, FT E():2e-06, (20.1% identity in 942 aa)" FT /gene="SPCC364.05" FT /product="putative vacuolar protein sorting-associated FT protein" FT /protein_id="CAA18287.1" FT /translation="MSDIELHESAIPKELDSPVTTIALYNNHLYFGTEGGDVFLYNFSN FT FQLNESPELVKKISLVSKSRVNRILAMPFLGAVFIHHGSFAEVYKEDDLTQLYPSISFK FT GLVEFCHPGQRIDEKSTYLIVTNTHLKLISFQKDGIILVKNELKYPNIQTARVNGHIVC FT LVTENSFELLDILTFDTTPLFPIIKYDSENNGLMYKPMIVLHSNEFLLITGSPKDAIGL FT FVDSQGNVTRSTLTFSFYPKHVFSTSHYVFAISSSSLQIIDINTLSLVKSINLKDDESF FT SFISRLTSVHFCDRQIFSKFSAVNTASTSKTSDTIERASFSKPSFIFLTNKSWGFGAEA FT HFMNKLEFSITIGDIEAPLRRVSKRLRNPKKYGITNDVAYLQSAYLEQISALQYWKQGQ FT YENSLSLLETSKIDPRVVISLYPDLYHSELSYIAFQGVISFRKSILSVDDTVANVLKSN FT ELFRDTDQYTQRQMIEITKENAYIMLMRYLKNYKKNTSISEYLLSSQRDVMLAVEHSLL FT LLYLNMDDLAAGTKNAKELLESGLTGVEDIKDVLIQKKEYYLLSVLLATVRDHDGVLQT FT WKKLITGDYEDRRFNDGLIKIREYLVNDIEPSTFWEFTTWLCKHDATEGTRVLLDKTVS FT GSISAEDVLEHLDSSQDDVLIDYLVKSNSVTHRALLLKLCVNKLLGSLLDHNDFKNRLE FT TAIETFRELPCMEKPTYAQYLEQLWGDMSDFSTHLSFYYLCSINLMENVEEESIDKIKD FT ILFDIHVDNLYLFPQLEHSFYKRKKNYEKALSVLVTNIHDYKGGEAYCLQIDDVYPQCW FT CNLLEKCISTGDGCSDFIKELLYRRPFSYTLSYVCEQIPDHWNLNLLADFLCILQKRNA FT ERLNESQTRLTLEKSLSQNLEELFMAINRRNVALGKNEI" FT misc_feature complement(6521..6539) FT /note="ctaattaacaataaacaag, splice branch and acceptor" FT misc_feature complement(6571..6576) FT /note="gtatgt, splice donor sequence" FT misc_feature complement(6765..6777) FT /note="ttaacggtggtag, splice branch and acceptor" FT misc_feature complement(6811..6816) FT /note="gtgtgg, splice donor sequence" FT misc_feature complement(6923..6938) FT /note="ttaacacgcgtattag, splice branch and acceptor" FT misc_feature complement(6971..6976) FT /note="gtttgt, splice donor sequence" FT misc_feature complement(7042..7062) FT /note="ctaactatttgatttttttag, splice branch and acceptor" FT misc_feature complement(7084..7089) FT /note="gtaagg, splice donor sequence" FT CDS join(7904..7955,8013..8123,8190..9928) FT /db_xref="SPTREMBL:O59795" FT /label=SPCC364.04c FT /note="SPCC364.04c, len:633, SIMILARITY:Saccharomyces FT cerevisiae, YKR9_YEAST, hypothetical 77.5 kd protein, (679 FT aa), fasta scores: opt: 539, E():1.9e-20, (29.3% identity FT in 645 aa)" FT /gene="SPCC364.04c" FT /product="similar to casp proteins" FT /protein_id="CAA18286.1" FT /translation="MAVASEALLQKLTESWKNSRFEELQREADEAAAEIEKMQKTSLDE FT RKELSSKTKEFRKQPDEVKLGEMKGLLKLYQSGIDSLTKRAKSAEATFFRVYETLGEVP FT DPYPLLIEAANNLKTQKQIEDLKKEKEEMEGSLQGKEKLEREVENLRKELDKYKDLVET FT EAEKRAAITKEECEKSWLEQQKLYKDMEQENASTIQKLTSKIRELQASQLDHDLQASQN FT ESAGLDVNAKSAEVNAILSELDDANKIIVELQAEIAVLKQNTKEQKSGSSQDDLSNQQK FT QQLDFMDSLNKKLSTELESIKEASRKEMETHCATIQTLENEVKEARKVKEESLTLANKF FT SDYDEIKRELSVLKQIEFSGEHATHENTSLESQLLKREKQLSEELAKLRSTNAQLTDRI FT TQESKKASFLEQKASEQEEVIRKLEKDLADVDVEGSVYLSNTTYRREGTSGQLSPTSSI FT MGGNPSLFNGSVLSRNSVNETGSAIVDVIKQQRDRFRRANVTLVNQVSAANDKIALLES FT KLEEVEKSNTLLYEQMRFRDHYQKHVEPSSSHLQTAAAYENSISPFASFRKKEAERAYS FT RMGSFERIVYALLRTLLFSRATRGLFFMYLILLHLFIMIVLLKLGIAGNTAYTPMNY" FT misc_feature 7956..7961 FT /note="gttcgt, splice donor sequence" FT intron 7956..8012 FT misc_feature 7996..8012 FT /note="ctaacgtgagataatag, splice branch and acceptor" FT misc_feature 8124..8129 FT /note="gtatgg, splice donor sequence" FT intron 8124..8189 FT /note="confirmed" FT misc_feature 8170..8189 FT /note="ctaatattgttaatatacag, splice branch and acceptor" FT CDS complement(10412..10975) FT /db_xref="GOA:O59794" FT /db_xref="SWISS-PROT:O59794" FT /label=rpl17-2 FT /note="SPCC364.03, len:187" FT /gene="SPCC364.03" FT /gene="rpl17-2" FT /product="60s ribosomal protein l17." FT /protein_id="CAA18285.1" FT /translation="MVRYSAAPALETKCAKARGAYLRTHFKNSREVAFTINGMNLKKAF FT IFLDNVKEHKQAVPFRRFNGGVGRTAQGKEFGVTQARWPVKSVNFFYDLLKNAEANAEA FT KGLDMDKLIIKHVQVNAAPKQRRRTYRAHGRVTAYLSSPSHIEIIVAEEEEAVPKANDT FT VSRVSLKQGAKARNLAARKAITSA" FT mRNA 10437..10454 FT /note="mRNA from AU007951 97 114" FT misc_feature complement(10520..10927) FT /note="Match to Ribosomal_L22 Score 234.18" FT misc_feature complement(10526..10600) FT /note="PS00464 Ribosomal protein L22 signature" FT CDS 11762..12916 FT /db_xref="GOA:O59793" FT /db_xref="SWISS-PROT:O59793" FT /label=SPCC364.02c FT /note="SPCC364.02c, len:384, SIMILARITY:Drosophila FT melanogaster, O44424, es2 protein, (414 aa), fasta scores: FT opt: 151, E():0.1, (23.2% identity in 349 aa)" FT /gene="SPCC364.02c" FT /product="hypothetical protein" FT /protein_id="CAA18284.1" FT /translation="MSLAKKIDDDEKQLVKPVNKEQTYKKPIPLEEDDYIEGLSYIIQQ FT QYFPDLPKLKAEVVLESEEVGSFDAQNESRDEKLKYLIAKNSEDPLRKRLPSLAIHEIT FT KAQLDGENKPISVASYQNKFTSEDNASFGELMEDESRLRAEQHKRRFGVHSQQPSNSIQ FT TIGYSNSDAIKSIAWKEKDKSIKTWNYQPKNALMYTPETNHSSSLSQIKKQSTEIQADA FT TGLSQSFLEAANQPSTDPIVPPSVNETDASVNGYPLVDVNFGQAVGSSSKSYFNIPERP FT RRERLHAMRVRDIRSHSTNTTITSVDSASTALNSYSTPNSVSRKLTNLTPAARRLVARS FT YLRSPLHGSSPSASRHTALRTSIPKFSWTPTPRVKSTAPTPKRV" FT CDS join(complement(14154..14156),complement(13142..14101)) FT /db_xref="SPTREMBL:O59792" FT /label=SPCC364.01 FT /note="splicing may be incorrect; non-consensus branch - FT may use internal Met @ posn. 1166" FT /note="SPCC364.01, len:320" FT /gene="SPCC364.01" FT /product="hypothetical protein" FT /protein_id="CAA18283.1" FT /translation="MSEEIITESIVKNFGSAETSVGEKQPKRKRSEVRAEKLKARKLQK FT AAEIVQKQKENRKILKDVSLKRLSKSLDRSLPSENTIDQISFNHAMSEEDASGYQIGDK FT HKNLLLYKLSSSSGSVFTENLYSTIQEFLSAQKVDIADSKNTYVFGSTFDKKSHALVKT FT SDSVRSLKYGSFVKACAPLFRFASGIIKAHAPHFHQALLKLELAPSALRFGVFPNFSLQ FT SVSNGYMSMESNFSSIKYGFVVIIIVGELNDVELKIPAISHSLKLKDGSILVLRSSLLH FT QWYSLPKQSILYEIRLFAMSSLWHYEKNKSIKIAKKDDI" FT misc_feature complement(14102..14116) FT /note="cttatactttaatag, splice branch and acceptor" FT misc_feature complement(14148..14153) FT /note="gtaaga, splice donor sequence" FT LTR complement(14752..14990) FT /note="Tf2-type LTR" FT misc_feature complement(14835..14999) FT /note="nominal overlap with cosmid SPCC970, EM:AL031530 S. FT pombe chromosome 3" XX SQ Sequence 14999 BP; 5045 A; 2759 C; 2657 G; 4538 T; 0 other; aagaactcaa cctggtagcc ctcatccttc aagttgctca aagctgattg attaacgttt 60 tccaacagca aaatcttgat gtcttcggaa gcgaatggct tcaaagtacg agcaggagct 120 tgggagtaag acttgcgtac ctggaagtga ttcgagagga aggatgaatt attatcaggg 180 ggagacaaag ataatttgtt caaactatcc tcgacattac cacgacgacc gcctttaata 240 tccatacttt aaagaatcaa aaaaagaaaa gagaaaaaat ttaaaaaaaa aatatctgta 300 atgtaaagat acaagccaaa tccacctaaa aaatgaatga gatgagatga caaaaatcaa 360 aaggaacttt agtcaatcca acgctttttc aaaaagctaa atttcgttgt tgagctagta 420 accgaagtct tcgacgttgg tagaggaagg aacgaaggat gtaggtagaa ggaaaaattt 480 tcaccagcaa aactataacc caacaaatga gtgcagacga gacacactat atataacgga 540 tgattaggtc accactataa tgaattgcga ctttgatgga ttcgtgattg aaatcgatca 600 taccattgaa attgatggat gttgattaaa cgggttgaac ggtcacggga aagatgaaaa 660 aaaaaacatt agatgagaaa aaaataaaga caaatttgta atagcaagca ggtacgagaa 720 ttgggcttga gagaaagaaa atataaaata aaaaaattga atatagaaga aaaaggtata 780 atcagaaata aattcaaaat tttaagcaag aaatcgtaaa aaatgaaatt ttcaactaga 840 aatgtttttc tttttccgtt tttttttagt gtacaacttg ctgtttttag aggaatattc 900 attattactt actatttact agtatttgct ttctttacta gtatttaatt attaaaaaat 960 tgtgttttta tttttgtatc ccaactaatt tatttattta ttctttcttt cttttttatt 1020 tactataact tgtgtgtttt ccctacttta aaattatttg tttcctttag tagtagctag 1080 ctggatttta tttctttgta cctttgatag atcatttgta gaatccattt tattaaaact 1140 tacgaggaaa aataataaat caaacaaatc tgatatatca catgagctta gttaaatttg 1200 aattgacttt cagtgttttg agtccaccaa attgctgcaa caatattata caactaaacg 1260 cattccatca aattggacgc tgttttattt aggacctttg cattatatac taaaaacatt 1320 cttaagttgc aaatgaatat aaagaatttt caatataaaa attgccaaaa attttcgaca 1380 ccagcaggat ttgaacctgc gcgcggagac cgcaacagat ttctagtctg tccctttaac 1440 cactcaggca tagtgtctaa gtcgaaaatt ataaaagcta taatatattt aaggcaagta 1500 ttaaaattaa aatattagat gttgtaagag atatgtcaaa tatgctttaa atttagacta 1560 agataaattg tagtatgcaa tcctccatcc caattgtaat catctccatt atttgatgat 1620 tctaacttta aaaaacaaaa ctggtatctg ttaaacgcta gacgaactta ctataacaac 1680 cgaacactct tttacaatgc gctccgcatt tttttagttt ccttcttact ccaagaattg 1740 caagcttctt tatgtctaaa aaaacgaaaa aaaaacaaat cgtatttttg ataaactttg 1800 acactcattt ctttcgaaat agccttttat gtaaacacat cgggtttagt tataccttcc 1860 caacttcttg ggtagagtag actaactagg atgcaaccca ttcatactat gaattctcaa 1920 ttgcttactt ctaagtcaaa acaaagcatt attttctaga aaagctcgta aaaagggttc 1980 tcttttttaa gctttactaa aggtcaattt ttacagtcag tgttttcaac ttggtctaaa 2040 ctaacaataa aaaactatca ctagttcttt tcgcaagcat ttgattgaaa aaaaaggcaa 2100 gaaaatatta aaacgtccaa gtttgtccga gcgttttcat catgattgat caaatataag 2160 cattccaaaa tctttaaagg ctttcgtact caaactagaa actcggaaaa ttcgccaaga 2220 acgatcacac ctcccattat gtagacgatg tcgtttaggt cttttaaagc cattcatctc 2280 aaaaccacca attccagtaa aaaataaaac acgtcgactg taagcatttt tatttgataa 2340 acgaaaaaaa ctcgataaat tggaagatat ttaaaaactt tataaacttg cagaatctcg 2400 tccgcaagca ctcacatgtg gtccgaacct atcctgtaca acaaaaggtt tacaaatgtt 2460 gcatgaaaac ctcaagaatc atacttttca agtatctttc ctttagtcaa aacacagaaa 2520 acccattgtt attaacccca taatatatgc acattatcga aattgtttat tgctgacggc 2580 actcagcagc gttttgctgg ccatgagcag tgtgcttgct atcactgtcc tcctcatcgg 2640 aatcggaaac ttcttcgtta gaagaggatt caacatcatc ttcatcctct tcaacatcta 2700 agtcgctgaa tccgtcatag ttttcaagag ctaaagcctc accagtaaac cactcaacgg 2760 cacgaggaat gagtttctct ttgaagtcct caccgatttg atagtcaagt tccaacaatt 2820 catccaattc agggctctcc gattcttcgt cttcctcaga tggaggagtt gggggattaa 2880 aaaagttgaa gaaactgtca cgaggaacgg aaacctttac gacacgagtt tgtttagtgt 2940 ttttattgcg ttgcttttta gtaacggtac gaacagtcaa atcggcattt tctttccaat 3000 caaccttatc gccctcagca tgatcataca agaaaacgtt ggacgggcca gattcctcca 3060 tgtaataata agttttggtg agaatcttgt tagtaaagaa tgggttttca gcaaattcaa 3120 attctaattt gaaaccaggc ttttccatat aggaaatgcg aatatccaca aggtgactta 3180 aagctccttc atcttcggga gtaatcattt cagacaaaga caaaacattc ttcatagcgg 3240 tcaaccagaa ctcaggaata cccttagtat catcaccacc ttcttgtttc ttagactcag 3300 aagaagtagg ttctttcttt tcgttctcat cggcagcttc acccttctta atttcctcct 3360 cggtaggttc gtcagcgcca cgaacaacct cagatcttct cttaaaaata ggtgcgtact 3420 tctttgcata agctttttcc aactcaaaca gctctttttg gaattgagac tccaagtcgc 3480 tgtatcgctt ttgcaaacca cgaagtccag aaatccttct ttgcacggct tcaggcaatt 3540 ctgaaactcc ttctgaagtg agatgtaata aagaacccaa ttttccgtcg atagcctcta 3600 aattctcatc tccttcgtca atagtattta cttgaggagc cttcgcacca aagttgggag 3660 cgctcgtccc cgatggggtg ttatggggag ttggggcggc agacattttt ccggcccttt 3720 tgttattaat attaacgttc tctaccatat taattctact tgttccagca atcaattatg 3780 cttcagacgc tttccgtacg tccttttaat aacactggga agggtagtgg tagaagctaa 3840 gtgtaagaat atttgctgca ccctgggaat ctacctaccc gcggaacttc cgagctcatc 3900 ctcggggttt ccgaccttag tgaacagtgc atcgttgtgt tacggacact ttctttattc 3960 ccgaaggggg tttttaaaaa taaaattcga tgaatttagg ctcatagtta atattattta 4020 tatttttaag actagtaaag atcaggaaga gctgaattaa ctgtagaaga aagcccttta 4080 tattctaaca acattttgaa gctagaatct ttttgtctca ttgaaattat tctatcatta 4140 aattaaacat cagtcgaata agtatcgaaa attgaggtaa aaactttgct gaaccaaagg 4200 ttacttttta aatgttactg ggttaaattt cgtttttgcc caaggctaca ttacgacgat 4260 taatagccat gaacaactct tccaaatttt gagacaacga cttctcaagt gttaaacgag 4320 tttgggattc attcaaacgc tcagcatttc ttttttgcaa tatacacaaa aaatctgcta 4380 ataagttaag attccaatga tctggaattt gctcgcacac gtaggaaagc gtataagaaa 4440 agggtcgacg atacaatagt tctttaataa aatcactaca tccatctcct gttgatatac 4500 atttttcgag caaattgcac caacactgag gataaacatc atcaatttga agacagtatg 4560 cttcaccgcc cttatagtca tgaatattcg taaccaaaac ggataaagct ttttcataat 4620 tcttcttcct tttgtaaaac gagtgttcaa gttgaggaaa tagatataaa ttgtcaacat 4680 gaatgtcgaa caaaatatct tttattttat ctatagattc ttcttcaaca ttttccatca 4740 gattaataga acacaaatag taaaatgaaa gatgagtact gaaatcactc atgtcccccc 4800 aaagttgttc caagtattgg gcatacgtag gtttctccat gcaaggaagc tccctaaatg 4860 tttcaatggc agtctcaagg cgatttttaa aatcgttatg atccaataaa ctgccaagca 4920 acttattaac gcacaacttt aaaagtagcg ctcgatgagt gacggaattc gactttacaa 4980 ggtaatcaat caaaacatca tcttgagaag aatccaaatg ctctaacacg tcctctgcag 5040 aaatggatcc actaactgtt ttgtcaagca aaacgcgcgt accctccgtt gcatcgtgtt 5100 tacaaagcca tgtagtaaat tcccagaatg tcgaaggctc aatatcatta accaaatatt 5160 ctcgtatttt aattaaccca tcgttgaatc tccgatcttc ataatcccct gttattaatt 5220 tcttccaagt ttgaagaaca ccatcgtgat cccttacagt agccaataac acggagagta 5280 aataatactc tttcttctgt atcaacacat cttttatatc ttcaacacca gttagaccag 5340 actctaacaa ctccttagca tttttggtac cggcggctaa atcatccata tttaaataaa 5400 ggagtaataa cgaatgctct acagcaagca tcacgtctct ttgcgaagat aaaagatact 5460 cagatatgct cgtgttcttt ttgtaatttt tcagataacg catcaacatg atgtatgcgt 5520 tttccttagt aatttcaatc atttgtctct gagtgtattg atcagtatca cgaaacaatt 5580 cattagattt taaaacatta gcaacagtat catcgacgga caatatgctt ttgcgaaaac 5640 taatgacacc ttgaaaagca atataggaaa gctccgaatg atagagatct ggatagaggg 5700 agataactac gcgaggatca attttggaag tttcaagcaa agagagagaa ttttcatact 5760 gtccttgctt ccaatactgt aatgccgaga tttgctccaa ataagcagat tgaagataag 5820 cgacatcatt ggttattcca tacttcttcg gattccgcaa tcgcttactc actcgacgca 5880 gaggggcttc aatatcgcct atggtaatac tgaattctag tttgttcata aaatgagctt 5940 cagcgccaaa cccccaagat ttattcgtaa gaaaaataaa tgaaggcttg ctaaaagaag 6000 ccctttctat cgtatcagaa gtttttgagg tagacgcagt attcacagca gagaatttac 6060 taaatatttg gcgatcacaa aaatgaacgc ttgtcaatcg agaaataaaa gagaaacttt 6120 catcatcctt cagattaata cttttaacaa gactgagagt atttatgtcg atgatctgta 6180 acgaactaga agaaatggcg aacacataat gagatgtaga aaaaacatgt tttggataaa 6240 atgaaaaagt tagagtgctt cttgtgacat tcccttggga atctacaaaa agccctatgg 6300 catctttggg actaccggta atcaagagaa attcattaga atgcaaaaca atcatgggtt 6360 tgtacattag cccattattt tccgaatcgt atttgataat gggaaagagg ggagtagtat 6420 caaaggtgag aatatccaat aattcaaagg aattttcggt aactagacaa acgatatgac 6480 cattcacacg agcagtttga atattggggt atttaagttc cttgtttatt gttaattagc 6540 gcttttatga agtaaacaat ttagcatcta acatacattt ttgactagta tgattccatc 6600 tttttgaaat gagatgagct ttaaatgagt attggtcaca attaaatatg tgcttttctc 6660 gtcaatacgt tggcctggat gacagaattc caccaagcct ttaaaggaga tggaagggta 6720 aagctgagtc aaatcatctt ccttgtatac ttctgcgaaa ctacctacca ccgttaattg 6780 gtattccaaa gttatcgtaa accacacata gcttaccatg atgaataaaa actgcgccaa 6840 gaaaaggcat tgcaagaatt cggtttacac gagatttcga caccaacgaa atcttcttta 6900 caagctctgg tgattcattt aactaatacg cgtgttaatg caaacaaccc tgtgcaacac 6960 acgaataaac acaaacctgg aaatttgaaa aattatagag gaatacatca ccaccttccg 7020 ttccaaagta tagatggtta tctaaaaaaa tcaaatagtt agcaatatag ccccggatgc 7080 ttgccttact atagagcgca atggtagtta caggggaatc caattcttta ggaattgctg 7140 actcatgcag ctcaatatca gacatttgta aattttgaat taatgaaaag attcattaaa 7200 caattatatt catgaaaaag ccctttgtaa gtgtatctgt tgcgttaata tggttacttt 7260 caatatgagt agatctgggt agcgtgtaac ccatagtaaa cgaaatgtta tgatatagaa 7320 agaaagtaaa tttagaattt ctgctaattt aaataaaaat tagattctat tacaaaacta 7380 actattcaaa tacgtggaat ccttatagga gattctcttc caatcttaat ccatagtaat 7440 tctaagttaa cttgcaagca tcctgggagt tatagcaatt tgagatagcc tcacagagtg 7500 aaatagcagg aactataata attgcacaca gaagtgattg tatgtttgtt gactgactta 7560 atttcaagtc tcttcgaaaa ttaattgact gaataatttg atagctgatc taaaaagatt 7620 ggccttttgt caataggctt tgcattattc ccaaaataca aggctacaaa agcaaaatca 7680 atacaatata caatcacttt tccaatcgaa ttaagcgcct aatacatatt actcatttcc 7740 ataaaaacaa attcttatag cgaagtgttt aatggaacgt tgtgtaactc ccaattcact 7800 atttcagcac gctgacatcg cgctatttca ttgaaatgct aagcacaaaa caaatactaa 7860 acattagtca ttttagtgtt tcgttttaat aacttgcaac ataatggcag ttgcttcaga 7920 agctttactc caaaagctaa cggagtcatg gaaaagttcg tggtgttttg aatttttaag 7980 caaatagcaa agttactaac gtgagataat agattcgcgg tttgaggaat tacaacggga 8040 agcagatgaa gctgcagcag aaattgagaa gatgcaaaag acatctttgg atgaaaggaa 8100 agagctttcg tcaaaaacga agggtatggt gtctattatt gcagcatacc tagtatacat 8160 taacccttgc taatattgtt aatatacaga atttcgcaag cagcctgatg aagtcaagct 8220 aggcgaaatg aagggccttt taaagcttta tcagtctgga atcgattctt tgaccaaacg 8280 agcaaagtcc gctgaagcaa cattctttcg agtgtatgaa acactaggcg aggttcctga 8340 tccctaccct ttgctgattg aggctgcgaa caaccttaaa actcaaaaac agattgaaga 8400 tttaaaaaag gaaaaggaag aaatggaagg ctcgctacag ggtaaggaaa agctggaacg 8460 tgaagtggaa aatttacgaa aagagcttga caaatacaag gaccttgtag agactgaagc 8520 ggaaaagcgt gccgcaatca caaaagaaga atgcgaaaag tcttggcttg agcaacaaaa 8580 gctatataaa gacatggaac aggaaaatgc tagtacgatt caaaaattaa cttcaaaaat 8640 tcgggaatta caagcatcac aactagatca tgatttacag gccagtcaga atgaatcagc 8700 agggttggac gttaatgcca aatctgccga agtgaatgct attctttctg aattggatga 8760 tgctaacaaa atcattgtcg aattgcaagc agaaattgct gtgctcaagc aaaacaccaa 8820 agagcaaaag agcgggtcgt cacaggatga cctgagtaac cagcagaaac aacaattgga 8880 ttttatggat tctcttaata aaaaattgtc tactgaattg gaatcaataa aggaagcatc 8940 aagaaaagaa atggaaacac attgtgccac cattcaaacg ctggaaaatg aagttaaaga 9000 ggcccgcaaa gttaaagaag aaagcttaac attggccaat aaattttcgg attacgacga 9060 gattaaacga gaactatctg ttttaaaaca aattgaattt agtggagaac atgcgactca 9120 tgaaaacact tctctagagt ctcaattact caagcgcgaa aagcaactat ctgaggagtt 9180 ggccaagcta cgctccacaa atgcccagtt aactgataga attactcaag agtcgaagaa 9240 ggcttcattt ttggaacaaa aagcttctga acaagaggag gtaattcgaa aactagagaa 9300 agaccttgcc gatgttgatg ttgagggaag tgtttacttg tccaacacca cctatcgccg 9360 tgaaggaact agcggtcaac tttctccaac atcgtcaatc atgggtggca atcctagttt 9420 atttaacgga agcgtgttgt caaggaattc agttaacgaa actggttctg ccattgttga 9480 cgttatcaaa cagcaaagag atcggttcag acgtgcgaat gtaactttag taaaccaagt 9540 gagtgctgca aatgacaaga ttgcattatt ggagagtaaa ttggaggagg tggaaaagag 9600 caacaccctt ctttatgaac aaatgcgttt tcgcgaccat tatcagaagc atgttgagcc 9660 tagctcttct cacctccaaa ctgccgcagc ctacgaaaac agcatttcac cgtttgcctc 9720 gtttcgtaaa aaagaggctg aaagagctta ttcgagaatg ggttcttttg agcgaatagt 9780 gtatgcttta ttacgcacct tgttattcag cagagcaact agggggttat ttttcatgta 9840 tctaatactt ttgcatcttt tcattatgat tgttctttta aaattgggaa tcgctggcaa 9900 taccgcatat actcctatga attattgacg aaattaaaag tcactgaacg agagtggagc 9960 tagtacctac taataagcac ttcaaatatt gccttagatg gaaagtatgc tgtctcaggg 10020 aatggattat gaagggaagg gaactgaaat agtgtgtata cgaaaataac gctcatctac 10080 attgatctgt ttcttttata tatataatat atacctatct ctatatatat caacaaagaa 10140 cattgaaacc caccatggaa ctcatttgtt ttgttttgtt attttttttt taattttaat 10200 ctaattaatt tattcttttg gtaacattcc agctacttgt ttgctttcgt atagattttt 10260 ttttctgtta ttattgagaa gacactttta taaaattaca gtcaatttct aaggactacc 10320 cacaacataa ataggaaatg aaaaagaaac tcatattaca accgaatcca ttcgtaaaat 10380 caaataggga cgaccttttt caaaatctat tttaagcaga agtaatggcc ttacgagcag 10440 ccaaatttct agccttggca ccttgtttca aagaaacacg ggaaacggtg tcattagcct 10500 tgggaactgc ttcctcctct tcggcaacaa tgatttcaat gtgggaaggg ctggaaaggt 10560 aagcagtgac acgaccgtgt gcacgataag tacgtctgcg ttgcttggga gcagcattga 10620 cttgaacatg cttgatgatg agtttatcca tgtccaaacc cttagcttca gcattagcct 10680 cggcattctt caaaaggtcg tagaagaagt tgacggattt aacgggccag cgagcctggg 10740 taacgccaaa ttccttgcct tgggcagtac gaccaacacc accattgaaa cgacggaaag 10800 gaacggcttg cttgtgctcc ttgacgttgt caagaaagat gaaggccttc ttcaagttca 10860 taccattaat ggtaaaggca acttcacgag agttcttgaa atgagttctc aaataggcac 10920 cacgagcctt ggcgcatttg gtctcaagag caggagctgc agaataacgg accatcttta 10980 atttacaatt tgtcaaggcg tttgcgcagt acaaaatttg tatggcagcg tttgtctagg 11040 attctctgtg actgtttttt agggtagtac tgtttggtgg tgcattggta aaactagtgc 11100 tgcaacgtat tctgctattt gtatactgcg agctagaccg tgcaccttag tatagcacta 11160 ttttctgagt aaataaatat tgtacatgaa ttaggtctat gaatactcaa attgtgtcta 11220 tcaaactacg atctcaatga aaaatagcag agttttattt tccttggaag tctactttat 11280 gatatacaag gaaaaataga taccatgttt aaaatgttga tgcaagtaca tttggtaggt 11340 gaaatagata atcaacaaaa acagtttctt aggccgctag ttgtgattgt gatgaaagaa 11400 atgtatgttt tcaatgacag agtatttttt tttaaatcaa taaaataatt ttatctgatg 11460 ttctactaaa acagagtaat taaaataatc aatttgaaag ttagtgggtc gacgctgttt 11520 aatccccata acttacttgt aattgtaagt acgccttaac tgtagaacag taaataggta 11580 aatagccaaa tttgagcaat tgagcaatcg ttatcttctt aatgagaaag aaaaataatt 11640 caataatttg ttttgctaac catctaaaac ctcacaacct tgtttagttg cttttcatgt 11700 cggtgtccta ggcatcccta ccacacttct ggaaattacc aattgccaac atcttgcata 11760 catgtccttg gcaaaaaaga tcgatgatga tgaaaaacag ttagtaaaac ctgtgaataa 11820 agaacaaacg tacaagaaac caattccact tgaagaagat gactacatcg agggtttaag 11880 ctacataatt caacaacaat attttcctga ccttcctaag ctgaaggctg aagtcgtgct 11940 cgaaagtgaa gaagtaggaa gttttgatgc acaaaatgag tcaagggatg aaaaattgaa 12000 atacctcatt gctaaaaact cagaagatcc attgagaaag aggcttccat cgttagctat 12060 tcatgagatt accaaagcac agctggatgg agaaaataaa ccgattagcg ttgcttccta 12120 tcaaaataag ttcacatcag aagacaatgc ctcttttgga gagctaatgg aagatgagag 12180 tcgattgaga gctgaacagc ataaacgacg atttggggtc cattcacaac agccatctaa 12240 ctccattcaa actattggtt actcaaattc tgatgcaatc aagtcaattg catggaaaga 12300 gaaagacaag agtattaaaa cttggaacta ccagccaaag aatgccttaa tgtatactcc 12360 agaaactaac cattcttcat ccctgtctca gataaaaaag caaagcactg aaattcaagc 12420 ggatgcaact ggcttatcgc agtctttttt agaagcagcc aatcaaccta gtacggaccc 12480 aatagtcccc ccgtctgtca atgagactga tgcttctgtc aatggatatc ctttagttga 12540 tgttaatttt ggacaagcag tgggatcctc ttcgaaatca tacttcaaca tcccagaacg 12600 gcctcgacga gagagactac atgctatgag agtgcgcgat attcgttccc actccacgaa 12660 taccaccatt acatcagtgg attctgcatc aactgcttta aattcttatt ctactcctaa 12720 ctctgtatcc agaaaactga ccaatttaac tcctgccgcc cgacgtcttg tcgcacgttc 12780 gtatctcaga tcacctttac atggttcttc tccgtctgct tctcgtcaca ccgccctaag 12840 gacttccatt cccaaattct catggactcc taccccgcgg gtaaaatcga ctgcccctac 12900 acctaaaagg gtttaatgaa ggacttgtct agtttatgta gtaattaact agagcaagca 12960 taatgataag tgcattgtac attctttaat ttattgatga tttctagaaa ttatagtagc 13020 ttttaaatgg tatgaaatat atgaatttat taattaaccg accgtgttac caaccttgct 13080 cgtaatgtca acattcgaca ctttagtgaa aaataaaact tcatttcgac tgatgaatag 13140 ttcaaatatc atcttttttg gcaattttta tggatttatt tttctcgtaa tgccaaaggg 13200 aagacattgc gaatagacga atttcatata aaatgctttg ctttggtaat gaataccact 13260 ggtgtaaaag agaggagcgg agaacaagaa tgctaccatc ctttaatttt aaagaatgag 13320 aaattgcagg gatttttaac tcaacatcat ttagttcccc tacgatgata atcacaacaa 13380 aaccatattt aatagaggag aaattagatt ccatagacat gtagccgtta gaaacgcttt 13440 gaagagagaa gttaggaaag acgccaaatc ttaaagctga aggagccaat tcaagtttta 13500 ataaagcctg gtggaaatgt ggtgcatgcg ctttgattat tccacttgcg aagcgaaaca 13560 gaggtgcgca tgcttttaca aagcttccat attttaggga cctcacacta tcagaggttt 13620 tcactaatgc atgtgacttt ttgtcaaacg tagagccaaa aacataggta tttttagagt 13680 ctgcaatatc aaccttttga gcagataaaa actcttgaat agttgagtat aggttctccg 13740 taaaaacaga tcctgaagag gaagaaagct tatataaaag caaattttta tgcttatcac 13800 caatttgata accagaagca tcctcttccg acatagcatg attaaaagaa atctgatcta 13860 ttgtattttc tgatggaaga cttcgatcga gagattttga caaacgtttc aaagaaacgt 13920 cttttaaaat ttttctattc tctttttgtt tttgaacaat ctctgctgcc ttttggagct 13980 ttcgtgcttt taacttttca gctcgcacct ctgaacgttt tcgtttcggc tgcttttctc 14040 ccactgatgt ttcagcagaa ccaaaattct ttacaatgct ttctgttata atttcttcac 14100 tctattaaag tataagcctt ctataagtta taacaataat aatattttct taccattttc 14160 acttattctt ctccacagaa gcacgtttta gaagggttca cgaattcctc ctagtagtta 14220 atatgtactt aacagcaata atggaactaa taaaggaagg agtgttttac gcctgctttt 14280 acagatgatt gtaaaaatgg aatttgaaaa tactaaaata atcaaatctc gaaattcacg 14340 aacttggaaa tgcaataaca atttctttct gccaaactta tagctactta ggatactcag 14400 gcagaagcag taattgagct tactagtgca caattcagta aaattttatg ctttgtacca 14460 ataaatgaat gcttaattaa atgtaaattt aagagaatct ctcgttacta catcaagcta 14520 tgactgccgc caactttaac atcgtagatg ataccaaacc acttaggttc ctaaggaaaa 14580 ttaaatataa aaaaaaaata ataataataa taataatcta tactacttga aatgttattg 14640 aaggcttgga aatttacata tttaagtaaa gcctcatata caaaagccac tttattatga 14700 tcgatactga actactcaat tctccattta agggcggcat tttaatgaaa ttgtcagcta 14760 cgcagtttga tatctgttta acgatacatt gaactgcaat gactctcttg tgaaactaca 14820 gcatagcggt atgcattttg ttaactaaga atattatatt tattgttata gggatgtcta 14880 atagtatcag ttaccgattt agctaataac tgaactgagg aatgagacgc agctgtaatt 14940 ccatttataa tcttcccaat ctttgttctt aactgatgtc tatattaaaa aagatgatc 14999 //