ID SPCC23B6 standard; DNA; FUN; 21110 BP. XX AC AL109608; XX SV AL109608.1 XX DT 28-JUL-1999 (Rel. 60, Created) DT 28-JUL-1999 (Rel. 60, Last updated, Version 1) XX DE S.pombe chromosome III cosmid c23B6. XX KW CRAL/TRIO domain; lysine-rich protein; oxysterol-binding protein family; KW phosphotidylinositol kinase; replication factor-a protein 3; KW ribonuclease II family member; RNB domain; sec14 cytosolic factor; KW single-strand binding protein; ssb3; tel1; telomere length control. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-21110 RA Lyne M., Brown S., Quail M., Harris D., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (27-JUL-1999) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; O74630; O74630. DR GOA; O94541; O94541. DR GOA; Q92374; Q92374. DR GOA; Q9UUA1; Q9UUA1. DR SPTREMBL; O74630; O74630. DR SPTREMBL; O94541; O94541. DR SPTREMBL; Q9UU99; Q9UU99. DR SPTREMBL; Q9UUA0; Q9UUA0. DR SPTREMBL; Q9UUA1; Q9UUA1. DR SWISS-PROT; Q92374; RFA3_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c23B6 is overlapped at the 5' end by cosmid c1322, EMBL CC entry SPCC1322, accession number AL035259, and at the 3' end by CC c645, EMBL entry SPCC645, accession number AL049498. XX FH Key Location/Qualifiers FH FT source 1..21110 FT /chromosome="III" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c23B6" FT /map="IIICEN" FT misc_feature 1..104 FT /note="nominal overlap with cosmid SPCC645 S. pombe FT chromosome 3" FT CDS join(complement(2605..2688),complement(2446..2477), FT complement(2274..2351),complement(664..1939)) FT /db_xref="GOA:Q9UUA1" FT /db_xref="SPTREMBL:Q9UUA1" FT /label=SPCC23B6.01c FT /note="SPCC23B6.01c, len:489, SIMILARITY:Neurospora crassa, FT P87046, oxysterol-binding protein, (360 aa), fasta scores: FT opt: 1240, E():0, (53.7% identity in 348 aa)" FT /gene="SPCC23B6.01c" FT /product="oxysterol-binding protein family" FT /protein_id="CAB51560.1" FT /translation="MRKWEIANEVCVDEKQDRDAEEIEDEGKNIILGIVSQLRPNMDLS FT KVTFPTFVLEPKSMLERITNFMSHPDLLLNVQKTADPEMRFLDVVRFYMSGWHIRPRGV FT KKPLNPILGETFTGFWKFPPSNSKDPNLQKLHGIAVYAAEQVCHHPPISAYFYLCPEYK FT VRIDGVVKPRSRFLGNSAASIMEGIASIKLQDLDEEYLITQPNVYARGILFGKMRLELG FT DHVTVRCPKTDLQADIEFKVKGFISGTYNSIAGKVKRVSTGEVLYKISGKWDSEMSVES FT VKTGETRPLLDVSKHDVYLVSARPLEEQGERESQRLWYKTCQAVIARDQTTATETKSAI FT EDRQREEAKQREIENVQWKPKYFKMIAPEEYILNFDIPNGKSDLEVLCALDEFIPIFSE FT VDRIAFHKFLSENTKPEDSSIHKHSRDASGDSTKGFAEHMPAPARRRRPQSTASFVTYR FT SDNGSVDEYHDAQLPDPNTLSKLHEEQDPAL" FT misc_feature join(complement(2446..2477),complement(2274..2351), FT complement(901..1939)) FT /note="Match to PF01237 Oxysterol_BP, Oxysterol-binding FT protein Score 315.64" FT misc_feature complement(1940..1960) FT /note="ctaacctcttgaaaattctag, splice branch and acceptor" FT misc_feature complement(2268..2273) FT /note="gtatgt, splice donor sequence" FT misc_feature complement(2352..2369) FT /note="ttgaccacatgttcgcag, splice branch and acceptor" FT misc_feature complement(2440..2445) FT /note="gtatgt, splice donor sequence" FT misc_feature complement(2478..2496) FT /note="ttaacgaatttttatttag, splice branch and acceptor" FT misc_feature complement(2599..2604) FT /note="gtaggt, splice donor sequence" FT CDS join(complement(4183..4498),complement(4003..4106)) FT /db_xref="SPTREMBL:Q9UUA0" FT /label=SPCC23B6.02c FT /note="SPCC23B6.02c, len:139, " FT /gene="SPCC23B6.02c" FT /product="hypothetical lysine-rich protein" FT /protein_id="CAB51561.1" FT /translation="MAKKQSIRSRNFRRSDPAYDLDSSTAIENETKLSVKEKVAKEIAN FT IALRSGGSESNGISKKKKNKKQTSKKAKDKLAAALKAQAREERLDTKISKSLQKQEKLK FT APRRRISFNRVYVYINFSMGYRGFFSWFLCKLFWI" FT misc_feature complement(4107..4126) FT /note="ctaacggatcaccaacttag, splice branch and acceptor" FT misc_feature complement(4177..4182) FT /note="gtaagg, splice donor sequence" FT CDS complement(4931..13369) FT /db_xref="GOA:O74630" FT /db_xref="SPTREMBL:O74630" FT /label=tel1 FT /note="SPCC23B6.03c, len:2812" FT /gene="tel1+" FT /gene="SPCC23B6.03c" FT /product="phosphotidylinositol kinase, tel1p; telomere FT length control" FT /protein_id="CAB51562.1" FT /translation="MTSLNDIVNKLSSSKIKTRSDALQNLRSYIIYSRNGNSLNQEDAL FT IIEKAIKRAFELEWQISANHGKRQISKASQEQKLQDISYLLRTCVESYILLFREPHILA FT LLDIILRHTFTANGSICEVVCLNFSKALRLLLSHSPHLHHLRFSDWQSLVSYCCQAIEK FT LSIAEETYVSDSEEEPISQKNYQEISIWKSHDVIRVKQEVVELIYVMRSLVQWYAAPIN FT FVSEQLLKFFEFFFYAYTEETDAHLPALQCLFQLCAYAIPNCNDYSASVVLLVFKILIN FT SDKWKRLDLRLQLIQCLAISYPLWSNSETWDPHRSIRSFNLDLLNSSFFSLKNFLNFFG FT KRSSLSLANFRFHTVEPKNNIAKLYDPRLHLFFSLRHNSFFESYFIYFFLAKLILLKKT FT VLSLASTEQANKKQKTCSQIEELLLQAELANISASSFSLQLMVIITAISDNLTNDDLLS FT IQKMSLNFTEKKNELQSWSFFILFNICYNKAYSSMLTTSCKKEILAAASRGLLNSVTSP FT VCYQILTYFNMYRPLCFASIFPFIKQQFILFNDYSPMLSYEAIDYWKSLYILLNENLFV FT GQSSFKSVFLKWLKWHLYHLFSKEGELPFFSFTDSSIIIFDLLMMIFYRPLSLSYITTE FT IRSPFERNLFHLKEAWSPVTLRFPYTTDEICKQSTEGCYPFNSNHTIDCDSLQNVIKML FT ESSIDEISSASYDKDELDKETPSFEAVMIFSQISFLCGFLNCFIQKKGIHNVTPNNLVI FT FKNLFPEVLSFVKSNHSYDPIINCISTNLQFTISDEPKHLRYEIGSDLIRSTHFRDSNP FT LKTLVLYIMDMASKNVFIKPQEFDHDEYFSQEEEDIYRPENLIRNHQILGLMEGSLEQI FT RNTDLFILQKYIDYFSSHPHDSLINILHLYPIETFCFGMSAIGAYFLDVARTSEPIFYK FT CLEILAQKILMNYDYERDEVYLMIFIKIFQKCVHSKLQFTDATLKLIVKITKFIEKVFI FT ETKFSSLSGRQTFLKFIFQLSPTSHVYSKFDYQKLISLTLKDSDVCVIYNFVDDLVIFL FT KKCDKTLIEGFVLPILSIKIEKSLYKGFCYLYLTLKVFLSISSNRSALLYQLLKLANSY FT ETSTIFEPLLRKLHIQSANIKQLFRIYRLEIFWSFVSKDLSNTTNDFLEFPYKPIYFSL FT SDFLKENSDEIILVLILTKNITLAKLITSRMSVDFSEKYTQLIPVITTYTHLSEVENKK FT YSLRFNSIDEALDVELLNRSKAFLFCLEMLKEVKELGSTFKSISSTSFKVYSQLTIFAN FT RVSFNNSTAIPFFSTKSVLWYCNRLFQELEGFSSIPSVIDLVLRRLAIQLHFATDEELQ FT VTISFRLCAFLCFSDPFITSNYLVMIVLRIARQLLSIPCTQSLGLGIARFHLKKFKPTD FT FDYFFQLAEFCMDFLGFCYNTIGTKMEAIQDFYTWFDGYVTALLNFEYEGYGFLRCQIN FT FVRSVMTTKNEWIEVSNKLFERGHFLKRIAMNNYLCLYFWQVLDACPRNVLHSLSLEIW FT KCYKAYDITEFPDSLKLFFSDIMGWNFFKSPEIADLNHYIPKTDPRLCDTKTYEESKLI FT IWKLICQKACSLLFKYDILLDSFIEDCIRMFFENGNHQELRKFLNFPKDSIIYDSDFKT FT LVSEEGSFQWVKLQPTNFDSLSNWTKEETLKLLNMMGKSSTTHSLKLLSTYMVGFSTSI FT IQYIIHLILLEFDFNGNNKKQKEYVTQLILSGLLNKNTNSIRKTCMNILLYLRRQLGHH FT ALNPFEANYWVPINYSVAASTAYDCHLYEQSLLFLTIHNTKTDELDITLLSDILSQLPC FT PDAYYGIKRETSFKNILLKAVHEKRSPLAISYLDAANMYRSNEDEGTKMMFSNTLNNAG FT FFSLNEFYIDSLKANDAIDECSNEVYASAWRMQKWDIPPLSLDNKTTKDCLVFEVLHAV FT HNYAIYGNYLHLEEYINKKLLLINPNEEPDSLLFYALAYDLKFLIRCNQSQFNCDILQL FT LKENKQMSSQLHECFQLLLEIRNVLLSLLQSHKQLDLSDDLASFRKYYILELLKISESF FT LIVDNLQNAFSVAMLSDALYRKFDLADENLKHDIDFLSSKILWQRDEKIDAIGMLSESL FT SKTNSSIFPSISYAYLGNWLYTTKSEKTELVSKNYFEKSLSHMSHLNAKEKAKIYCMFA FT QFCDNNYSSPDLTEDFKRMEKLYFEKKNDIQQLERSIVNASNMKEEKMLKNHHSREMSS FT FIIDEREYLRMSTFRSKMLTQSITHYLKCLSESDENDVLISRCCTMWLSNSHLDELNNS FT LQHYLQNLPCKKFIPVFYQLAARLMNENSKFQQSLTSICYNVGRNHPYHSLHVLFSLVS FT NVPEIENLDAGSRYRAVKKILDLLKVNQGLSNLVTKLLCSFENYVSLAEWNPRSKVDST FT SFSRFPGYKWFLKDAANYGLPPITMNVKVNDTGDYSNIPTVSSFDDTIHFASGINAPKV FT ITCLGSNGHTYKQLVKGGNDDLRQDAVMEQVFEQVNGFLRSYRKTSQRNLSMRTYKVIP FT LALKTGVIEWVQDTIPLGEYLDSAHKVYHPKEWSLSTCRKLIAEKQMEDLETRLKVYDL FT VCRHYRPVFRHFFLESYADPVQWFTTQTNYARSTAVASVLGHVLGLGDRHGQNILIDKT FT SGEVIHIDLGIAFEQGKKLPVPECVPFRLTRDVVDGMGITGVEGVFRRCMEFTLETLRR FT EEDSLLSVLEVLRYDPLFSWLISPLRRMKKQKMQLENFNQPESGNITTDASRDPKIQRN FT NVSGESEAERAILKVRQKLSSTLSVEASVGELIRIAQDPSYLALMFCGWSAFQ" FT misc_feature complement(5273..5590) FT /note="Match to PF00454 PI3_PI4_kinase, FT Phosphatidylinositol 3- and 4-kinases Score 145.16" FT misc_feature complement(5765..5917) FT /note="Match to PF00454 PI3_PI4_kinase, FT Phosphatidylinositol 3- and 4-kinases Score 28.48" FT CDS complement(13807..16833) FT /db_xref="SPTREMBL:Q9UU99" FT /label=SPCC23B6.04c FT /note="SPCC23B6.04c, len:1008, SIMILARITY at FT C-term:Saccharomyces cerevisiae, YNX1_YEAST, hypothetical FT 40.7 kd protein in sin4-ure2 intergenic region.hypothetical FT 40.7 kd protein in bni4-ure2 intergenic region., (351 aa), FT fasta scores: opt: 780, E():3.3e-32, (49.2% identity in 325 FT aa)" FT /gene="SPCC23B6.04c" FT /product="conserved CRAL/TRIO domain protein; SEC14 FT cytosolic factor family" FT /protein_id="CAB51563.1" FT /translation="MKDSEHHHHGHNGFSKFLHKLGFGKSKGKSHKSNTSSIHERENTA FT AKGPASNVRPARPNVSTSSTSNEVRKSVPVGNPTVHTKTGSSSSPASKMRNTVNLQHIQ FT AANQKTRNAEGERKVAQRRVQSDKAEANDAAMSSSAPTVDVSEGNSAAEPKITPDDSDT FT PRLNVDMNDKINVDEAAAKSDSKLNVDQINSTTESEKRVEKVNPNIANNPLKSPDAVAY FT SSETVSDEKQPTEHPVSANVPAKSEKAVCDENTKISLTNTEHYKFHSLRGDVEVVVGDL FT ERDGRDTSLGDASVNEAAKETDVDSSRFISDEKAVTEDAMKTEHASNAPLTDERHFQFH FT SSEGDIEGIVGTMQRQRQSVSSYDTIVPSQFYKQKVVQNSPPSLLSTDNKIPESGSDHP FT SSQDNSSKASLVENSQTQSSTPRKPLPTTTSPKVNPEPHSESISDTRPSTPRKVPPSTV FT PKMNPKLQGGNSVTAPSTPSKVLPAMSPKVAPKFQGGRSSTAPSTPNKVLPAASAKAAP FT KLQEKAASFDIPNKSTIISTKSTVASPIKANENSPALKSKASFEFPKELDPDGTWNAPI FT PYPDANCPMAPTYRNLTSEQEEMYEEVLKYCLELKEIPVASNSSKKTDLIELERLWLTR FT ECILRYLRATKWHVSNAKKRIVDTLVWRRHFGVNNMDPDEIQEENATGKQVLLGYDKDG FT RPCLYLYPARQNTKTSPLQIRHLVFSLECAIDLMPPGVETLALLINFKSSSNRSNPSVG FT QGKEVLNILQTHYCERLGRALVINIPWAVWGFFKLISPFIDPITREKLKFNEPLDRYVP FT KDQLDSNFGGSLHFEYHHEKYWPQLVELCKSRRLGILEKWRKMGSKIGTSEWDLKGGEE FT YVELMQQYVRPSLTNRSSSPTVTPTVNTDRQPKTLTNSADELSPQKRRVENPKPVVKDE FT GPVSIVEDEESTPVVTKKEDSIPVAQSTKADAGLDAENDLLPKSGSGVSETPAFSHARD FT VSTASFSDAVSFITADSIE" FT misc_feature complement(14365..14850) FT /note="Match to PF00650 CRAL_TRIO, CRAL/TRIO domain. Score FT 140.13" FT CDS join(complement(18152..18298),complement(17986..18088), FT complement(17820..17884)) FT /db_xref="GOA:Q92374" FT /db_xref="SWISS-PROT:Q92374" FT /label=ssb3 FT /note="SPCC23B6.05c , len:104" FT /gene="ssb3" FT /gene="SPCC23B6.05c" FT /product="replication factor-a protein 3" FT /protein_id="CAB51564.1" FT /translation="MERPTPRVTKDMLPECSGKTVRIVGKANQVEGETAKVDSNGSFDM FT HLTVDNTLEPNHFYEFVVSVKPDSSVQLLTCVDFGTDIDMEVYQKLVLFSHKYNSLFFE FT " FT misc_feature complement(17885..17904) FT /note="ctaatttcctgttcctttag, splice branch and acceptor" FT misc_feature complement(17980..17985) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(18089..18098) FT /note="ctaattttag, splice branch and acceptor" FT misc_feature complement(18146..18151) FT /note="gtacgt, splice donor sequence" FT CDS 19096..21110 FT /db_xref="GOA:O94541" FT /db_xref="SPTREMBL:O94541" FT /label=SPCC23B6.06 FT /note="SPCC23B6.06, len:670, SIMILARITY:Neurospora crassa, FT CYT4_NEUCR, mitochondrial protein cyt-4, (1117 aa), fasta FT scores: opt: 254, E():3.4e-08, (32.9% identity in 140 aa)" FT /partial FT /gene="SPCC23B6.06" FT /product="putative ribonuclease II (RNB) family member" FT /protein_id="CAB51565.1" FT /translation="MNYRQLFLLQNVNLESNYLLKRVCLSLKLSPCKLTRKFHHACPSS FT SKVLKYFRITGCLINFGKQPANDHHLWGHCGARLKHTQSDLIDRFKNANLKSVNEENLK FT KFFSELENHGNIRQWLKDKFEKDKRAAVCPTTTKSEEEKLENDFEYSFDLEDFSSENFR FT QYDRGDLLVFYRGSEGIELAACTGTNVWNYSNVLTSINENGTIKEFRTSRVLLRCPNVF FT KKLKEVQQPLSDVSVPSDVLPFTIKLLKKISQRAQDLSRSHRNEFLRILTEFNIPNKLD FT NSASFSDLLKFVYKTSKPSPYAKISLLHFLLTESKHFLISDHIFSEIQKVYFLPSSQND FT SFDDVVACLRQKSTPYLSFIKKARHLIQVSRDKYKLPISTEEIKPVVYSQVTWTEFEKK FT LLRYLVQEMIAKSIQSLPNTHLCQVYKEVGLQTHERGLTSDQFAKFLTDIGVWASWQPP FT RLFQQEYSIAGLGTNPQLDAVYERECNHFKKFVKNELKDSLESQRVDLRHLKAFAFDSS FT STKEIDDAISVEELGMSNSWLHIHVANPTSTVDIRSPLGTFAERNFQTIYHPNKIVYML FT PLNITQKYWSLDSSSTAQRALTFSAKISKNGDILDYKVRPSFISSVIKYTPQQLDKALH FT SNRSIAKDIVSGPVDEETKGVSNDHMKDILRIYELS" FT misc_feature 21008..21110 FT /note="nominal overlap with cosmid SPCC1322 S. pombe FT chromosome 3" XX SQ Sequence 21110 BP; 6901 A; 3791 C; 3753 G; 6665 T; 0 other; cttactcctt tttccggact tttcttttag tccacatttt tatcgtttgg cactttaact 60 cgtttcatct gcgttgagta aaccactatg aatatcacaa gatccaagta actaacctag 120 tcagttctac gatatcaagt tctttgaaga aagcataaag caagcatttg ttaaataaaa 180 atttaccatt attgaataac gctcatcctg agcgttaccc aaaccggtag gatgaattat 240 ggaaacacat ttttgacgct tttgcttctc tactagagta atacactaac aaataaaacc 300 actttacatt tctattaaca tcggttcaca ctaccaaaac aaggtaggaa gtaacggaga 360 gtaaagaaag attgatatat aagaataggt taatagtgta taaagaacta aatcccaatt 420 aaggaaaaat atggtaaata acaacgttgc aatttatctc tcttcatcag ggatggactt 480 aactcactgg atgagagaca tgtccatatt aacattctaa attcagaaaa tcctcagcta 540 aaagaaaaaa gcattcttca ttcacgactc caaagacaga aaatcaatat aaaaaacaac 600 aaacgtatca aatataaacc acttaatcat aaaaatccat tagaacgaag tatttccttc 660 tcattataaa gctggatcct gttcttcatg taactttgat agagtattag ggtcagggag 720 ttgagcgtca tgatattcat caaccgatcc gttgtcactc cgatatgtta caaaacttgc 780 agtactctgg ggtcgtcgcc tacgcgcagg cgctggcatg tgttctgcaa atccctttgt 840 actatcgccg cttgcatcac gtgaatgttt atggatggag ctatcttccg gctttgtgtt 900 ttcagaaaga aacttgtgaa acgcaatcct gtcaacctca ctgaaaattg ggataaactc 960 atccaacgca cacaaaactt caaggtctga cttgccatta gggatgtcaa agttcagaat 1020 gtactcttca ggtgcaatca ttttaaagta tttgggcttc cattgaacat tctctatctc 1080 gcgctgtttt gcttcttctc gctgacgatc ctctatggcg gattttgttt cggtagcagt 1140 agtttggtca cgggctatta ctgcctgaca cgttttatac cacaaccttt gagactcacg 1200 ctccccctgc tcctctaatg gacgagcaga aacaagataa acatcgtgct tcgaaacgtc 1260 cagcaatggt cgggtctcgc ctgttttgac gctttccaca ctcatttctg agtcccactt 1320 tcctgaaatt ttgtatagca cttctccagt actgacacgc ttgactttac cagcaatcga 1380 gttgtatgta ccgctaataa aacctttgac cttgaactca atgtcggcct gtagatcggt 1440 tttgggacag cggacggtga catgatcacc cagttcgagt cgcatctttc caaaaaggat 1500 accacgcgca tacacgttgg gctgggtaat caagtactct tcatccaagt cttgtaattt 1560 gatactggca ataccttcca taatactggc cgccgagttt ccaagaaaac gagaacgagg 1620 ctttaccaca ccatcgatcc gcaccttgta ctctgggcat aggtaaaagt atgcgctaat 1680 tggtggatgg tgacagacct gttcggctgc atacactgcg ataccgtgca acttttgcaa 1740 attaggatcc tttgagttgg aaggagggaa cttccaaaat cctgtaaacg tttcacccaa 1800 aatgggattt aacggttttt tcacaccccg agggcggata tgccaaccgg acatgtagaa 1860 acgaactacg tccaagaaac gcatttcggg atctgcagtt ttttgaacat ttaagagcaa 1920 atctggatga ctcataaaac tagaattttc aagaggttag tacaacatcc ttttacattc 1980 aaaaatcttt tttttgctta ttatctttgt tttctctttt catttcctta aacaacactg 2040 ttttcataca tgcaaataag ctacttgctc atgcatttcc gggaatcggt caatttgagt 2100 gcatttcacc agatgcaccc ttccggctgg cggagatgta taacaaatcg tccacatatg 2160 cattgcgcaa ttgcccatga aatcgaccgt aaaccggaat tttataatga ccaggctgtg 2220 tctttgacgg aatttgaata caaagaaaat aaggagacta gcaatgtaca tactttgtga 2280 tacgttccaa catagactta ggttccaaca caaacgtcgg aaatgtgact ttggacaagt 2340 ccatattagg tctgcgaaca tgtggtcaat aacccgcccg tcaatcacgc aaaggttgtc 2400 atagaagact ttgaatttct tcacatctac ttcaacgtca catacctcag ttgggagacg 2460 attcccaaaa ttatgttcta aataaaaatt cgttaagatc aatcattcca acaaaattaa 2520 acttcatatc aaagttgtcg catctccatt agccattgta gtgtttgtca ccaactcaaa 2580 aaggcctttt ctatctgtac ctacctttcc ttcatcttca atttcctcag catctctatc 2640 ttgtttctcg tctacacata cttcgttagc aatttcccat ttcctcatct tttttcgtct 2700 tcaattcacg gttttctacg gtaacgcttc cgacgcgctt ctttttcgac atacgaggca 2760 tattttacga taatctcagt aactttcttg aaaatactac caaacaacct gaaatatttg 2820 agatttttta gatatgtacg ttgggttagt tgttggttca gtcaggcagt gtctaaagtc 2880 caaatttgtg gtagtaagta cttccaggtc taaatgacgt cagtcatctc agaaagctga 2940 aagtgatgct gtattagcaa aataaatgta aacaaaacca tctaaacgtt gaaattaatg 3000 caatactcat taatatttca tgataaattg taatttttag ttaatttacc aatttgcttc 3060 tttctatagt gatttttgtt aaattgagag atttagattt ttacgattgc tattatgttc 3120 cttaatggat atgcataaga aagtatatgg aggattataa agtattgagt gttaatagaa 3180 agatttgtat ttaggaagaa aaggaaggga tagaccaaag gggataggta cactacactg 3240 ggttgtaatt ttaaggaaaa ctcttccaac ttggttaata tcccaatgtt taaaaatgtt 3300 tagtcaaaca aaagaagata atttaaacaa taacattctc agatttcgat aacgcaagct 3360 tccatttttt acgattcaac gagttttggg ttttcaactt tacgatcaga atgctgtgtc 3420 aagctaagtt ttaaatcgtt caacaaatcc tttaccagat tttgattggt atattacaga 3480 atcataatga agggacattt ttgaatctcc tatgaaaaat accctctttt caagctcata 3540 cgaaatcggt tttcttaatg ccatactatt taaaatttct tacattaatt gacatttgtc 3600 cctcgtatta ttattttata ctcatcctga aaattttaca tccagaaaaa catttcactt 3660 aaagacagta caacttttcg tacgacttta ttgtttgtat gtggtatgtg gaaaaagtca 3720 ataccaaaaa ttagtactta tcttcaaaag aatttcacaa ctcatgtaat aaaaatacaa 3780 gagatatata tgttttccgt aaatccgcaa caggaagctt atacatgaac gtttgtcaaa 3840 aaatttcaat tacagtagga aggaagaaat atatatatat attggttata atccatctcc 3900 attcttgcta ggcaaattta tccaatcctg tcccgtaaaa gtttgtaaat gaaatataga 3960 ccgaaaggat ttcgattcga tattgttgaa ttccaaaatt aattaaatcc aaaataattt 4020 acataaaaac caagagaaga agcccctgta tcccatagaa aaatttatat acacataaac 4080 tctgttaaaa cttattcgtc tccttgctaa gttggtgatc cgttagtaaa ccttccctag 4140 atcaaaaaaa atcgaaaatt aataaaaacc ttcatacctt acgagccttc aacttttcct 4200 gcttttgcag cgatttacta attttggtat ccaacctttc ctctctcgcc tgagccttca 4260 aagcagcggc cagtttatcc ttagcctttt ttgaagtctg ctttttgttt ttcttctttt 4320 tacttatgcc gttgctctct gatcctccag atcttaaagc tatgttagca atttcttttg 4380 caactttctc cttcacagaa agctttgttt cattctcaat tgccgtagaa ctatctaaat 4440 cgtaagcagg gtccgatctc cgaaaatttc tactacgaat tgactgtttt ttagccattc 4500 ttagttgatt gtttgagtaa ttgctctggt agagtttatc gctgcattct acgttttagc 4560 cttcatataa cgtaactaaa aaacatttca gaatcgtaaa aatttttatt ggaaatattt 4620 atttctttta aagaaagaaa gataaataaa attacttagc attttattct taaaatgtac 4680 gtacaatttt caggttccaa tagtatgagc tggtaagctg acgcaaagat tttgtaggtc 4740 aaggttttaa gcgtgaatgt atagaaggaa ataatatcgg cccagcattc ttgcaaatga 4800 tacttacagt ttctcaaggg atcgtattaa ccatgaaacg tatattcaaa tgcatttcgt 4860 ttcactaatt gccaagaggt acgaattaat tagaaagaaa acactcatga aaataaatta 4920 actatatcgc tcattgaaag gcagaccatc cacaaaacat aagtgcgaga tatgagggat 4980 cttgagcaat tcgaatcaat tctcccacag aagcttctac tgaaagagta cttgataatt 5040 tctgtcttac tttaagtata gctctttcgg cttccgattc tcccgataca ttattccttt 5100 gtatcttggg gtctctagaa gcatccgttg taatattccc gctctctggt tgattaaagt 5160 tttcaagttg catcttttgt tttttcatcc ttctcaaagg tgaaataagc caagaaaata 5220 atggatcata tcttaaaact tccaggacag acagtagtga atcctcttcc cgtcgaagtg 5280 tttctaatgt aaactccatg catcttcgaa ataccccttc aaccccggta attcccatac 5340 catctacaac gtctcttgta agtcgaaagg gaacacattc aggaacgggt agttttttac 5400 cttgttcgaa agcaattcct agatcaatgt gaatcacttc tccactcgtt ttgtctatta 5460 aaatattttg cccatgtcta tctccaagtc ccaaaacatg tcccaggaca gaagcaacag 5520 cagtgcttcg tgcgtaattt gtttgcgttg taaaccattg cactggatca gcgtaactct 5580 cgaggaaaaa atggcgaaag acaggacgat aatgtctaca aactaaatcg taaactttca 5640 atctagtttc caaatcctcc atttgtttct cagctattaa ttttcgacaa gtactcaaag 5700 accattcctt aggatggtaa accttgtgag ccgaatccag atactcaccc aagggaatgg 5760 tatcttgaac ccactctatg acacctgtct ttaatgctaa tggaatcacc ttataagtac 5820 gcattgacag atttctttga ctggtttttc gatagctcct gagaaatccg tttacttgct 5880 caaacacctg ttccataaca gcatcttgac gaagatcatc attcccccct ttaaccaact 5940 gtttatatgt gtgaccattt gagcccaaac atgtaataac ttttggcgca ttaatccctg 6000 aggcaaaatg aatggtatca tcgaatgaag aaacggtagg gatgtttgaa taatcacctg 6060 tatcatttac ctttacgttc attgttatag gaggtaatcc atagtttgct gcatctttta 6120 gaaaccattt atatccagga aatcgactaa aagatgtact gtcaactttg ctcctgggat 6180 tccactctgc taaacttaca tagttttcaa aggagcacaa aagtttggtg actaaattgg 6240 ataatccttg attaactttt aacagatcaa ggattttttt aactgctcta taccgtgatc 6300 cagcatcgag attttcaatt tctggaacat tggacacaag cgaaaacaaa acatgcaaag 6360 agtgataagg atgattacgt ccaacgttgt agcatataga tgtcaacgat tgttgaaatt 6420 tcgagttctc gttcatcaaa cgagctgcca attgataaaa gacaggtata aactttttac 6480 aaggcaagtt ttgtaaatag tgctgtaagg aattgttcag ttcatctaaa tgtgaatttg 6540 aaagccacat agtacagcat ctagatatca aaacatcgtt ttcgtcactt tcacttaaac 6600 atttcaaata atgagttata ctttgagtga gcattttact cctaaaagtt gacattctta 6660 aatattcgcg ttcatcaatg ataaatgaag acatttccct agaatgatgg ttttttagca 6720 ttttttcttc cttcatatta gaagcattta caatggaacg ctctaactgt tggatatcat 6780 tctttttctc aaaataaagc ttttccatac gcttgaaatc ttcagtcaga tccgggctag 6840 aataattatt gtcgcaaaat tgagcaaaca tacaataaat tttagctttt tctttggcgt 6900 tcaagtgtga catatgggaa agggatttct caaaataatt ttttgagact aattcagtct 6960 tttcggattt tgttgtatac aaccagtttc caagatatgc atagctaata gatggaaaaa 7020 tggacgaatt tgtttttgaa agtgattcgg agagcatgcc aatggcatca atcttttcat 7080 cacgttgcca taagatttta gatgaaagaa aatctatatc gtgcttaagg ttttcatctg 7140 ccaaatcaaa ctttcgataa agagcatcac ttaacatagc cacggaaaat gcattttgaa 7200 ggttgtcaac tattaaaaaa gactcgctaa tctttaagag ttccaagata tagtacttgc 7260 gaaatgaggc tagatcgtca gacaagtcca gttgtttgtg tgactgtagc aaggaaagta 7320 ggacgtttct aatttcaagt aataactgaa aacattcatg taactgtgat gacatttgct 7380 tattctcctt aagcaattga aggatatcac aattaaactg agactgattg catcgtatta 7440 aaaacttcaa atcataagcc aaagcataaa atagtagact atcgggttcc tcgttgggat 7500 taattagtaa taattttttg ttaatgtatt cttcgaggtg caaataatta ccgtaaatag 7560 cgtagttatg cactgcatgt aatacctcaa aaaccaaaca atccttagta gtcttattgt 7620 ccaaagaaag tggagggata tcccattttt gcatccgcca agcagaagca tacacttcgt 7680 tgctgcattc atcaatagca tcattggctt tgagtgaatc gatgtaaaat tcattcaagc 7740 taaagaatcc agcgttatta agagtatttg aaaacatcat cttagtcccc tcatcttcat 7800 tgcttcgata catatttgca gcatcgaggt acgaaatggc taatgggctc cgcttttcat 7860 gcaccgcctt gagcaaaata tttttgaagc tagtttcgcg ttttattccg taataagcat 7920 ccggacaagg cagttgggaa agaatgtccg ataaaagggt gatgtccaat tcatctgttt 7980 ttgtattatg tattgtcaag aaaagtagac tctgttcata caaatggcaa tcataagcag 8040 ttgatgctgc aacactgtaa ttaatgggaa cccagtagtt tgcttcaaat ggattaagag 8100 catgatgccc taattgccga cgaaggtata ataaaatatt catgcaagtc tttcgaatac 8160 tatttgtatt tttatttaac aaaccagata agatcagttg tgttacatac tccttttgct 8220 ttttgttgtt accattaaaa tcaaactcca acagaatcaa atgtataata tattgaataa 8280 ttgaagttga aaaccccacc atgtaagtac tcagcaattt tagagaatgt gttgttgatg 8340 attttcccat catatttaat aatttcagcg tctcttcctt agtccaattt gacaaagaat 8400 caaaatttgt gggttgtaat tttacccatt gaaaagaacc ttcctcagaa acaagagtct 8460 tgaaatcact atcgtagatg atactatctt ttggaaaatt taaaaatttt ctaagctctt 8520 ggtgattacc attttcaaag aacatcctaa tgcaatcctc aatgaatgaa tctaataaaa 8580 tgtcatattt aaataaaaga gaacatgctt tttgacatat caatttccaa ataataagtt 8640 ttgattcttc ataagtttta gtatcgcata atcgaggatc ggttttgggt atataatgat 8700 tgagatcagc aatttccgga gatttgaaaa aattccagcc catgatgtct gaaaaaaaga 8760 gcttcaaaga gtcaggaaat tcagtaatat cgtatgcttt gtaacatttc caaatttcaa 8820 ggcttaagga gtgtaaaaca tttctgggac aagcatcgag gacttgccaa aagtagagac 8880 aaagataatt attcattgcg attctcttaa gaaagtgacc tctttcgaac agtttatttg 8940 aaacctctat ccattcattt ttggttgtca tcactgaacg tacaaagttt atttgacagc 9000 gtaaaaatcc ataaccttca tactcaaaat ttagtaaagc agtaacgtaa ccatcaaacc 9060 aagtataaaa atcttggata gcctccatct tcgtaccaat agtgttgtag caaaaaccca 9120 aaaagtccat acagaattcg gctagttgaa agaaataatc aaaatcagta ggtttgaatt 9180 ttttcaaatg aaagcgcgca attcctaatc ctagtgattg ggtacaaggt attgagagta 9240 attgtctagc tatcctaagt actatcatta ccaaatagtt tgaagtgata aaaggatcag 9300 agaaacatag aaaagcacac aatctaaaag aaatagtaac ttgaagttct tcatccgtcg 9360 caaagtgtag ttgtattgca agtctcctta aaactaaatc aatgactgaa gggatagagg 9420 agaagccctc taattcttgg aagagtctat tgcaatacca taacacagat tttgtagaaa 9480 agaatggtat cgctgtgcta ttgttaaaag agacgcgatt ggcaaaaatt gttaattgtg 9540 agtacacctt aaacgaagtt gagcttatag atttaaaagt agagcctaat tctttaacct 9600 ctttaagcat ctctaagcag aacaaaaaag ctttggagcg gttgagtaat tccacatcaa 9660 gtgcttcatc aatagaatta aatctcaacg aatacttttt attctctact tcacttagat 9720 gagtataagt tgttataaca gggatcaatt gcgtatactt ttcagaaaaa tcaacagaca 9780 tgcgtgaagt aatgagttta gccaaggtta tattcttagt cagaataaga acaagtataa 9840 tttcgtcgct gttttctttt aaaaaatcgg aaaggctgaa ataaattggt ttgtagggga 9900 attctagaaa gtcattggtt gtattagaaa gatctttgct gacgaatgac caaaatatct 9960 ctaacctgta tattcgaaac agttgcttaa tatttgcact ctgaatgtga agcttacgaa 10020 gcaaaggttc aaaaatagtt gacgtttcat agctgtttgc aagcttaagc agctgataca 10080 acaatgctga tcgattggaa cttattgaca aaaaaacctt taaagtcaaa tataaatagc 10140 agaagccttt atacaatgac ttctcaattt taatgcttaa aattgggaga acaaaacctt 10200 caattaacgt tttatcacat tttttaagaa aaatcaccaa atcgtcaaca aagttataaa 10260 taacacaaac atcagagtct ttaagagtta aagaaatcaa tttttgataa tcgaattttg 10320 aataaacgtg agatgtaggg gataactgaa atataaattt taaaaaagtt tgtctaccag 10380 ataatgatga aaatttagtc tcaataaaaa ccttttcaat gaattttgta atcttcacaa 10440 taagtttcaa agttgcgtcc gtgaactgaa gtttagaatg aacacatttt tgaaatattt 10500 taataaaaat cattagatag acttcgtctc tttcataatc ataattcatt aaaatttttt 10560 gagccagtat ttcaagacat ttgtagaaaa taggttcgga tgtccgcgca acatctagga 10620 aatatgcacc aattgcagac ataccaaaac aaaaagtttc aatgggatac aaatgaagaa 10680 tattaattaa gctgtcatga ggatgactag aaaagtagtc gatatatttt tgtaaaataa 10740 aaagatcagt attccgtatt tgctcaagcg atccttccat caaaccaagt atttgatgat 10800 tcctgattaa attttctggc cgataaatat cttcttcctc ctgggagaaa tactcatcgt 10860 gatcaaattc ttgaggcttt atgaatacgt ttttagaagc catatccatt atataaagaa 10920 ccaaggtttt gagcggatta ctgtctcgaa aatgagttga acgaattaag tcgcttccaa 10980 tttcataccg aagatgtttt ggctcatcag aaatagtaaa ctgcaaatta gtagagatgc 11040 aatttattat tgggtcataa ctgtgattag acttaacgaa agaaaggact tcagggaata 11100 aatttttaaa aatgacaaga ttgttaggag taacattatg aatacctttt ttctggataa 11160 aacaatttag aaagccacat aaaaatgata tctgagaaaa tatcataact gcttcgaagc 11220 ttggggtttc cttgtcaagc tcatctttgt cataagatgc tgagctaatt tcgtctatcg 11280 agctctccaa cattttaatg acattttgca aactatcaca gtcaatagta tggttactat 11340 tgaaaggata gcatccttct gtagactgtt tacatatttc gtcagtagta taaggaaaac 11400 gaagcgtaac aggcgaccat gcttctttga ggtgaaacaa attacgttcg aaaggtgatc 11460 gtatttctgt ggtgatataa gataatgaca acggtctata gaagatcatc attaacaaat 11520 caaaaatgat aatagaagaa tcggtaaatg agaaaaatgg tagttcaccc tctttgctga 11580 acaaatgata tagatgccac ttcaaccatt ttagaaacac agatttaaaa gagctttgac 11640 caacaaatag gttttcatta agtaatatgt acagagattt ccagtaatca atggcttcat 11700 atgaaagcat tggcgagtaa tcattaaata aaataaactg ttgctttatg aaaggaaaaa 11760 tgctcgcgaa gcacaaaggc cgatacatgt taaaataagt taaaatttga tagcatacag 11820 gagacgtaac agaattcagg agaccacgag aagcagcagc caaaatttcc tttttacatg 11880 aagtcgtaag catcgaagag taagctttgt tgtaacaaat gttgaacaat ataaaaaaag 11940 accagctttg aagttcattt tttttctcag taaagttaag actcattttt tgaattgaca 12000 atagatcatc gtttgttaga ttgtcagaaa tagcagtgat aattaccatg agttgcaatg 12060 aaaaagagga agccgagata ttggctagct cagcttgcaa aagcagttcc tctatttgag 12120 aacatgtttt ctgctttttg ttggcttgct ccgtgcttgc taaggacaac acggtttttt 12180 tgaggagaat tagttttgca agaaaaaaat aaataaagta agattcaaag aaagaattat 12240 gtctaagaga aaaaaaaagg tgtagccgtg gatcgtaaag ttttgcaatg ttgttcttag 12300 gctcaactgt atggaatcta aaattcgcaa gcgataatga ggagcgtttt ccaaaaaaat 12360 ttaagaaatt ttttaaagaa aaaaacgaag agttaagaag atctaaatta aaagatctaa 12420 tggaacgatg gggatcccat gtttctgaat tggaccaaag tggataagaa atggctaagc 12480 attgtataag ctgcaatctt aaatccagac gcttccattt atcagagttt ataagaatct 12540 taaagactaa taaaacaacg cttgcggaat aatcattaca attggggatc gcatatgcac 12600 ataactgaaa caaacactgc aaagctggta gatgcgcatc tgtttcttcc gtgtaagcat 12660 aaaaaaagaa ctcaaaaaat ttcagcagtt gctcactaac aaaattaatt ggagccgcat 12720 accattgaac aagagaacgc ataacgtaaa tgagctcaac gacttcttgc tttactctta 12780 taacatcgtg cgatttccag atagatattt cttgatagtt tttttggctt attggctctt 12840 cttcactatc actaacataa gtttcttcag ctatacttag tttttcaata gcttgacaac 12900 aataggaaac tagtgattgc caatccgaga aacgaagatg atgcaaatga ggagaatggg 12960 ataatagtag ccgaagagcc ttagaaaaat tcaaacagac tacctcacat atagaaccat 13020 tagctgtgaa agtatgtctt agaattatat ctagaagcgc taaaatatga ggctccctaa 13080 ataataaaat ataagattca acacatgttc ttaacaaata gctaatatct tgaagcttct 13140 gctcttggga agctttggaa atttgacgtt taccatgatt agcagaaatt tgccattcaa 13200 gttcgaatgc tcgctttatg gccttttcga ttattaaagc atcttcctga tttagcgaat 13260 ttccatttct ggagtaaatt atgtagctgc gaagattttg tagagcatct gatcgtgttt 13320 tgatttttga tgaagacaac ttattaacga tgtcatttag agaagtcata gtattacatc 13380 gagtaaaagt tatcttttct tcattaatat attaacatat ttggcgtaaa ctgataattg 13440 agtaaaaggt tacgcgtctc caacttttgg aatttggaag gttcatttag cgtgtacgaa 13500 ttttacagat gccaagttat aaattgaagt gtggtaattc ttcttattga aactaaaaag 13560 cacgaaacta tcaactatat aagaaaaaag gaattaaaac aaatgatctt ctttggaaat 13620 atcaatgact ctactgttag ctaaatatgt acagtaatag tggattttct tttttcagca 13680 ccgaattatt caaaagccct ctattaaaag ttttcaaggc tgtaaaaaaa gaaatcatag 13740 aactagctca attgcgaata aagtataaga gaaaagagtg aagaggtttc gagagcttaa 13800 gaaaaactat tctatgctat ccgcggtgat aaacgaaaca gcgtcgctaa atgaagccgt 13860 agaaacatct cgtgcatgcg aaaaagctgg tgtttctgaa acaccggaac cagatttggg 13920 aagaagatca ttctcggcat cgagcccagc atcagctttg gtggattgag caacaggaat 13980 agagtcctcc ttttttgtaa caacaggcgt cgattcctca tcttcaacga tagaaacagg 14040 cccctcatct ttgacaacgg gcttaggatt ctcaactcgt cttttttgag gagagagctc 14100 atcagcacta ttggttaaag tctttggctg tctatcagta tttacagttg gagtaacagt 14160 tggagaagat gaacgatttg tcaatgaagg acgtacatac tgttgcatta attcaacata 14220 ttcctctcca cccttcaaat cccattcgct tgtacctatt ttagatccca tcttcctcca 14280 tttttccaag atgccaagac gacgtgactt gcacaattcc accaactggg gccagtactt 14340 ctcatgatga tattcaaaat gaagagatcc accaaaattc gaatctaatt gatccttagg 14400 gacataacga tccaacggtt cattgaactt taacttctct cgtgtaatag ggtcaataaa 14460 tggagatatc aatttaaaaa aaccccatac agcccaagga atattaataa caagtgctct 14520 tccaagacgc tcacaataat gagtttgcaa aatattcagt acctctttac cttgaccaac 14580 gctgggattt gaacgattgg acgaagactt gaaattaatc aacaaagcca atgtctctac 14640 tcctggaggc ataagatcaa tagcacactc caatgaaaaa accagatgcc gaatctgcag 14700 tggtgaggtt ttagtgtttt gcctagctgg atataggtat aaacagggac gaccgtcctt 14760 gtcgtaacct agcaatactt gcttaccagt tgcattctcc tcttggattt catcaggatc 14820 catattatta acaccgaagt gacgacgcca taccaaagta tcaacaatac gcttttttgc 14880 attggaaacg tgccatttag tagcacgcaa atatctaagg atgcattcgc gtgttagcca 14940 aagacgctcc aactcaatca aatccgtttt cttgctagaa ttagacgcta caggaatctc 15000 ttttaattcc aaacaatatt taagtacttc ttcatacatt tcttcttgtt cagaagtcaa 15060 attccgataa gtgggagcca taggacaatt tgcatcagga taaggaattg gtgcattcca 15120 agtaccatca ggatctaatt ccttagggaa ctcaaaagat gctttagact tcaaggcagg 15180 actgttctca tttgctttaa ttggcgatgc taccgttgac ttagtagaga taatagtaga 15240 tttattagga atgtcaaatg atgcagcttt ttcttgaagc tttggagcag ctttagcaga 15300 tgctgctggt aataccttat taggagtaga gggcgctgta ctgctgcgtc caccttggaa 15360 tttgggagcc accttgggac tcatcgctgg caacacttta ctaggggtgg aaggggctgt 15420 aacgctattg ccaccctgga gcttcgggtt cattttagga actgtacttg gtggcacttt 15480 tctaggagta gaaggtcgtg tgtcagatat actttcgcta tgcggttccg gatttacttt 15540 aggactagtg gtagttggca acggctttct cggagtagat gattgtgtct gagagttttc 15600 taccaaggat gctttactgg aattatcttg acttgaggga tgatctgagc cggattctgg 15660 aattttgtta tcagtgctca acaagcttgg ggggctattt tgcaccacct tctgtttata 15720 gaattggcta ggaacgatag tgtcatacga agagacagat tgtctttggc gctgcattgt 15780 cccaacgatt ccttcaatgt ctccttcaga agaatggaac tgaaaatgcc tttcatcagt 15840 gagaggggca ttggaggcat gttcagtttt catcgcatcc tcagtcacgg ctttttcatc 15900 tgaaataaaa cgactagagt cgacgtcagt ttctttagcg gcttcattta ccgaagcatc 15960 gcctaaagag gtatctcttc cgtcacgttc caaatcacca acaacaactt caacgtctcc 16020 gcgaagtgaa tgaaacttgt aatgctctgt gtttgtaagc gaaattttgg tattttcatc 16080 acaaacagct ttttcagatt ttgcagggac attagcagat acaggatgct cagtaggttg 16140 tttttcatca gaaaccgtct cactgctata tgctactgca tccggtgatt ttagcggatt 16200 attcgcaata tttggattaa ctttctcaac tcttttttca gattccgtag tagaattaat 16260 ctgatcgaca ttaagtttgc tatcagattt agcagcagct tcatcgacat ttattttatc 16320 attcatatct acattaagtc tgggtgtatc tgaatcatcg ggtgtaattt ttggttcagc 16380 ggcagaatta ccttcggaaa catctaccgt tggagctgaa ctactcatgg ctgcatcatt 16440 agcttcagct ttatcagatt ggaccctgcg ttgagcgacc tttctttcac cttcagcatt 16500 acgagttttt tggttagctg cttgaatatg ctgcaagttg actgtatttc tcatctttga 16560 ggcaggagat gaagaagacc ctgttttggt atgtacagta ggattaccaa caggtacaga 16620 ttttctgacc tcgttcgaag tggaagatgt gctaacatta gggcgagcag gacgcacatt 16680 agaggcgggt cctttggcag cagtattttc tctttcatga atactgctgg tattgctttt 16740 atgcgatttt ccttttgact tgccaaaacc aagtttatgg agaaacttac taaagccgtt 16800 gtggccatga tggtgatgtt ccgaatcttt catcgtggtt ttgtatcgat aaaattaacg 16860 aatgttggtt ttgaataaac tattaacagt ttagattgca aagggtattc ttttcaccgt 16920 aaaagaagaa atatcaaagg aaattagaaa taatggaatt aaatgaaaaa aggtattttc 16980 ccaagactta aattactata gggttcgaaa tacttaactc ttttcttttt tctctatttt 17040 tagtaagaga tctcgatggt ttaccatgaa ttccaggata tcttttatct ctgtttcgac 17100 caatttaaca tgcaagcaag ttagattata ttcaaagaaa cgtgtctgat ctctaaagat 17160 aaggcgcaga cagaaatgca aagaacaaat gtcagatata tttagagtat ttcaatcgga 17220 gcaattccga aacaatccaa cttctgcata tgcacgtttt ctaacgttat ttctctaaca 17280 atctcaataa ctgctaaaca acagttttag caaaaaagtt tgtaaaggaa aaagtaatat 17340 aataattctc aaaacaacca attttcttta ggaataagcg atattcagcg tagtaccact 17400 agatatactt gcgttgctcg ctttgtatat atatggtagt tggattgtta caatggcagg 17460 gtgactgaag gatgagcaaa cgtaagaaac accggtatgt accgtcttcg gagccgaatc 17520 gtccgcgatg agcatctcaa ggatacacta aataagatag tgcgaaaaaa ggagaacgtt 17580 atataaaaat actcaaacaa gaatcaaaaa aagtgaaata aacgatagta aaattcatat 17640 ttgtattagc caaaaggaag aatcattata aaagaaaagc ttgagtttag aaatgcaata 17700 aaatatgcaa aaaccaaaag aaggaagcaa gattctgcgc gtttattctt ccatgtttat 17760 ttgtactgtg catgagaaat gaaagagaaa tctgtgttgt atgatccata aaatgtttct 17820 tattcaaaaa aaagtgagtt atacttatga ctgaatagaa cgagtttctg gtatacctcc 17880 atatctaaag gaacaggaaa ttagttaatc ggtcaataga atgtaggact tagcagaagc 17940 agaagttcaa aggacttcct tattattttt ataaacacaa cttaccaata tcagtgccaa 18000 aatcaacaca ggttaaaagc tgcaccgaag aatctggttt gacagaaacg acaaattcat 18060 agaaatgatt gggttcaaga gtgttatcct aaaattagtt agataaaata aaaaaactct 18120 gaaaaccgat tgtaaaatag ataaaacgta ccacagtgag gtgcatatcg aaagaaccgt 18180 tggaatcgac ttttgcagtt tcaccttcaa cttgattcgc cttgccaaca atccgaaccg 18240 tttttccaga gcattctggt agcatatctt tcgtaactcg aggtgtaggg cgttccatat 18300 tattttatac gcgttgttta taaagtggtg gaagtgaagt atgtatcaga ccaggtagtt 18360 aactacttgt tgacacgaat tatttaaaat attggaacgc agtacgttat gtattatatg 18420 ttggaaggcg ctgggatgta aataaaaaag caaaagcgta aatataaacg ctgggggcta 18480 acgttgatac attactgttc tattttttat aagaattatt cataaaaaaa tctccttgta 18540 tccttctgcg ttaatttcac tacttattaa ttggttgaaa tgttgtaaat aaacgggtta 18600 aagaccaata taaatacgtc ttacatatag tgatttaaat aacattatgg aaagatttca 18660 tggtatttta tactattttt gaaatcgtcg gcgactctta attttctctc ttttccaata 18720 ccactattag taaattgctt aggcgtagac cagaagcttc aataattaaa agtaaatgta 18780 attgatggaa agcagccttc ttttaatgat ataatttttc aattagtttt accttgaggt 18840 tgtgatttca tgtatttcac tttgaagtcg cccatcccct cgaccattca attcaaaaaa 18900 aaaaaaatca aaaaactcca tactcatatt gaaatctttc ttctgttaca ttagttatta 18960 aaccactctt catttacatt tgcagagctt gttaccttaa tacttgctag tacctaaaag 19020 tgctctggtt cagctctcta gtcgaattta ccatcaacac tatttttggt gttactaatt 19080 atagggtttt tgcccatgaa ctataggcaa ttgtttcttc ttcaaaatgt taatttagag 19140 tctaattatt tattaaaacg tgtatgcctg tctttaaaat tgtctccttg taaacttaca 19200 aggaaatttc atcatgcttg cccttccagt tcaaaagttt tgaaatattt ccgcataact 19260 ggatgcctaa taaatttcgg gaaacaacca gcaaacgatc atcatctttg gggacattgt 19320 ggtgcgcgtt tgaagcatac tcaatcagat cttattgatc gatttaaaaa tgctaatttg 19380 aaatccgtga atgaggaaaa ccttaaaaaa tttttctctg aattagaaaa tcatggaaac 19440 attagacagt ggttgaaaga caagttcgag aaggacaaac gcgctgctgt ttgtcctact 19500 actacaaaat ctgaggaaga gaagttggaa aatgattttg agtattcttt tgatttagaa 19560 gatttcagca gtgagaattt tagacagtac gatcgtggag atttgctagt gttttatagg 19620 ggctccgaag gcattgaact tgctgcatgc actggtacta atgtttggaa ctatagtaat 19680 gtattgacca gcattaacga aaacggtact attaaggaat ttcgtacatc tagagtttta 19740 ctgagatgtc ctaatgtctt taaaaagctg aaagaggtgc agcaacctct ttctgatgtt 19800 tctgttcctt ctgatgtcct acctttcact ataaagttat taaaaaaaat ctctcaaaga 19860 gcacaagatt taagtcgaag tcaccgaaat gaatttttgc gaatattgac agaattcaat 19920 attccaaata aacttgacaa ttcagcttct ttttcagacc ttttgaaatt tgtgtacaaa 19980 acttcgaagc ctagcccata tgctaaaatc tcattgttac actttttgct tacagaaagc 20040 aaacattttt taataagcga tcacatattt tccgaaattc aaaaagtcta tttccttccc 20100 tcttcacaaa atgattcttt tgacgacgtt gttgcatgcc tgcgtcagaa atcaacacca 20160 tatctttcgt ttataaagaa agctcgtcat ttaattcaag tttcccgaga taaatataag 20220 ttacctataa gcaccgaaga aataaaaccc gtagtttatt cacaggtcac ttggactgaa 20280 tttgaaaaaa aactattgcg gtatcttgtt caggaaatga ttgcaaaaag tattcaaagt 20340 ttaccaaata cacacttgtg tcaggtttac aaagaagttg gccttcaaac tcacgagagg 20400 ggattaacta gtgatcagtt tgctaaattc ttaacggata ttggcgtgtg ggcttcatgg 20460 cagcccccga ggttgtttca acaggaatac agcattgctg gccttggtac taatcctcag 20520 ttagatgctg tgtatgaacg tgagtgtaat cactttaaaa agtttgtaaa aaatgaatta 20580 aaagattcac ttgaatcgca acgcgtcgat ttaaggcatc ttaaagcgtt cgcctttgat 20640 agttcttcta cgaaagagat agatgatgcg atttcggttg aagaattagg gatgtctaat 20700 tcctggcttc atatccatgt tgctaatcct acgagtacag ttgacattcg cagtccttta 20760 ggcacgtttg ctgaaaggaa ctttcaaact atttatcatc ccaacaaaat tgtgtatatg 20820 ctacctctca atatcactca gaaatattgg agtttagatt catcttctac agctcaaaga 20880 gcattaactt ttagtgctaa aatttcaaaa aatggcgata tacttgatta caaggttcgg 20940 cctagcttca tttcctcagt tatcaaatac acaccccaac aactggataa agctttgcat 21000 agtaatcgat caattgcgaa agacatcgtt tctggaccag tggatgagga aacaaaagga 21060 gtatcaaatg atcacatgaa agatatatta agaatatatg aactttcgaa 21110 //