ID SPCC14G10 standard; DNA; FUN; 14000 BP. XX AC AL031518; XX SV AL031518.1 XX DT 08-SEP-1998 (Rel. 56, Created) DT 14-DEC-1999 (Rel. 62, Last updated, Version 2) XX DE S.pombe chromosome III cosmid c14G10. XX KW conserved hypothetical protein; HXC-26 homolog; KW phosphatidic acid-prefering phosphpolipase; proline rich protein; KW proteasome maturation factor. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-14000 RA Purnelle B., Goffeau A., Wood V., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (07-SEP-1998) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk and Unite de Biochimie Physiologique, Universite RL Catholique de Louvain, Place Croix du Sud 2/20, B-1348 Louvain-la-Neuve, RL Belgium XX DR GOA; O59766; O59766. DR GOA; O74414; O74414. DR GOA; O74416; O74416. DR SPTREMBL; O59765; O59765. DR SPTREMBL; O59766; O59766. DR SPTREMBL; O74414; O74414. DR SPTREMBL; O74415; O74415. DR SPTREMBL; O74417; O74417. DR SWISS-PROT; O74416; UMP1_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c14G10 overlaps cosmid SPCC18B5, EM:AL109736 at the 5' end CC and cosmid SPCC1020, EM:AL023518 at the 3' end. XX FH Key Location/Qualifiers FH FT source 1..14000 FT /chromosome="III" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c14G10" FT /map="IIIL" FT misc_feature 1..2457 FT /note="nominal overlap with cosmid S. pombe chromosome 3" FT CDS join(65..101,150..823) FT /db_xref="GOA:O74414" FT /db_xref="SPTREMBL:O74414" FT /label=SPCC14G10.01 FT /note="SPCC14G10.01, len:236, SIMILARITY:Saccharomyces cere FT visiae, YDR196C, YD96_YEAST, similarity to C.elegans hypoth FT etical protein T05G5.5, (241 aa), fasta scores: opt: 605, E FT ():0, (45.8% identity in 216 aa)" FT /gene="SPCC14G10.01" FT /product="conserved hypothetical protein" FT /gene="SPBC18B5.12" FT /protein_id="CAA20654.1" FT /translation="MLILGLTGSIATGKSTVSREFQEKYHIKIIDADVLARKVVEPNTP FT CLIKIQKEFGNEVLHEDGTLNRAKLGQAVFQDAGKRSLLNSIIHPAVRLEMLKELLRCY FT VRGYSIVILDVPLLFEAKMQFICWKTICVSCDKSIQKQRLLARNPELTAEDAENRVQAQ FT MPLELKCQLADIVIENNSDLETLYENIHNVLPLITPSYFFTLLCLILPPLQITLQVIAF FT VSQKKKVSEFRKHI" FT misc_feature join(68..101,150..664) FT /note="Match to PF01121 UPF0038, Uncharacterized protein FT family UPF0038 Score 232.14" FT misc_feature 102..107 FT /note="gtaagt, splice donor sequence" FT misc_feature 136..149 FT /note="ttaacctagttaag, splice branch and acceptor" FT misc_feature 299..388 FT /note="PS01294 Uncharacterized protein family UPF0038 signa FT ture" FT CDS join(1324..1354,1397..6072) FT /db_xref="SPTREMBL:O74415" FT /label=SPCC14G10.02 FT /note="SPCC14G10.02, len:1568, SIMILARITY:Saccharomyces cer FT evisiae, YKL014C, YKB4_YEAST, hypothetical protein, (1764 a FT a), fasta scores: opt: 285, E():8.9e-09, (21.0% identity in FT 1675 aa)" FT /gene="SPCC14G10.02" FT /product="hypothetical protein" FT /gene="SPBC18B5.13" FT /protein_id="CAA20655.1" FT /translation="MESGSIDLDKEIDELSRVLLEHPAHVEKVLKTVEFDKSALRYIDA FT ILDHHLKQIYRNLTSNSPLHTLSLLQKMASWNNGLACVRVFQAIDWNSKIFIKMLQLPN FT QIQNSRKGNKRLKITISKKRSSLLLLFITFLRLGTPEIRLEILNSRKLTTPLFKGIYND FT EPSVLKELLQCWLTYVLLDHDVSRATKLSYFNEWSLSCLASLYSRDDEIDGISLCNLVH FT KFFVDACTVPGEGLCFVSNGWHLQKKVDGQSKTIFNRVLQSFVFSLHVHTSTLQRELVL FT KILKACPDITASFIERNSLTSEPVLSYQWISFVSLLQAILGMGIPFPFYDAETRTVPPT FT NIIIENILPSSFSKPVVLKALNGNDKFVCFLTVNTLLASFKRLESVLDEIKRSELSEDN FT KVELVSKISDAILLRLPDSQTFVQLYSSTESDLLKEGLSRILLYFFTYFPENILKLKID FT TSIFLRLDLSPGMLDRPFSRLHVENIIQILRYLPEVKWFDVVRSPFVFLCLMYLQTSHS FT KLRDAIISTLNDVFSQTIIFCPSLAVPPILTILASLQHTSPTQHKAVLEFLNSCINRCI FT SRVFAYLDVCVDCFKKHSVNSQKKTAPEVSPISVTLIEQIPFFLQKRDISDDSKDAVLS FT WLSDLFSNLVCTGEDANCLFHLLENVNVTAFDSDYTLKPFNQLMSFIESLAVQKLPDYV FT NQIGSLSQYLLYSTNDELSNSGIQKFGMNLDFLPLYVVIITKRIAIMLQSGDMRVKKFL FT ELIRELVEFSKEETMATSQSPIRTLLSACINLRPFLLQEQYISFNMDFAEFLIDTNASI FT KGSVVNTCVLDFLYKSFSDKVQENYNLIRIAAKFMLLWTQEEFIGFSKALDSFLSENDD FT LIYKNLDYVAPLLFECMQFTSTTNANMFSNNSISVLLKAAILKPTKLTHGMFDALNTMK FT PIISDFTVFEPALHTVENFDLTDCADEQILLLSSFVNFVPLFRKVIWNLLLNNKEALIQ FT KYELLAILCCDLAKQYVAEQSQYDLERIRSFCSEVVENNLDLVLQKSHLIELLFPLMKL FT SDPKIQYYVKVSNALSEKYLPQGVLELLVLLQKRIDIPSSLRVQTIMRIFAILTRVLSD FT SPQIGLSLEKFLTNFEALIKMNVDILRDEIDKSTLNSFLESAIVHVTSFSNLRLCLTLA FT FTMTAEQCDSSRFLQMILAHEKNPLAGEDSSDEIKATMSAIICKLTIIGKNYTLSVLDQ FT ILKLFKGRYTLHDSLLCELLAYFETLDDISVASRYKGWVITDEYDMMLLARKDGSGVLE FT PKIAANTVNQYPSEWEKIDLKVFDDLETTEGLLSSYCSNEWNREVYHPLYALGITASLL FT HSNQQVSNIQVIVQQNFLGMIVMGLSLFKEEARFACLNFLRNFIPILDEQKFREKHLIK FT LVLASIIVNVPSSENRLSTLMANFYAFSLTVMMKPTHPLFVGINRYYLQRQHVDVTDIP FT MYYELLYPSTDYTKSVYWLLTLLHAGLQTNQDLKIYLRRHVFEMICTLYNSCVVNSEIR FT TLIEKILLKVVALGGGPMLVKYNAIYPMLQMVIPSFQETKENTVVSTT" FT misc_feature 1355..1360 FT /note="gtgagt, splice donor sequence" FT misc_feature 1383..1396 FT /note="ctaactccatgtag, splice branch and acceptor" FT CDS join(complement(6617..6850),complement(6357..6512)) FT /db_xref="GOA:O74416" FT /db_xref="SWISS-PROT:O74416" FT /label=SPCC14G10.03c FT /note="SPCC14G10.03c, len:129, SIMILARITY:Saccharomyces cer FT evisiae, YBR173C, YB23_YEAST, proteasome maturation factor, FT (148 aa), opt:240, E(): 1.9e-09, (36.8% identity in 125 aa FT overlap)" FT /gene="SPCC14G10.03c" FT /product="putative proteasome maturation factor" FT /protein_id="CAA20656.1" FT /translation="MKIVPDVEPAAEVSGNFKVSVLEPSIPAVHRVENKHPLESRLKNW FT EAQQQQIRLDSMRRIYGLHEPVRREMEQKLASQSSRPLALGGSANFHLDILANREAVLD FT ETDIYAAPIPLEMTYQNEMAIRYGL" FT misc_feature complement(6513..6527) FT /note="ctgactcaagcatag, splice branch and acceptor" FT intron complement(6513..6616) FT /note="confirmed Intron: intron confirmed by EST" FT misc_feature complement(6611..6616) FT /note="gtaggt, splice donor sequence" FT CDS join(7132..7226,7310..7369,7480..7532,7799..9084) FT /db_xref="SPTREMBL:O74417" FT /label=SPCC14G10.04 FT /note="SPCC14G10.04, len:497, SIMILARITY:Zea mays, Q41805, FT extensin-like protein precursor, (1188 aa), fasta scores: o FT pt: 196, E():0.0027, (24.9% identity in 313 aa)" FT /gene="SPCC14G10.04" FT /product="hypothetical proline rich protein" FT /protein_id="CAA20657.1" FT /translation="MSQVIQYSEADLLYLSKSPLIKKPENLPEWILPEAMKADRERHIR FT QEKEMKRHDDDGRQYQSDRKFAKSKHDDIILGPPKLSFASSNENGRSVGRHDDLLSLGN FT VYNGVASLRYRNGASVSRSSSIGHSGSTAPWSSVGRHNRKKDNEHRDEMEGLEKVMKQR FT AGNTGPLVANSTEEFEAWKRMMKASSGEAGAGNVITPGVTSTTGAPSGKASLSRAASNS FT STSARAGISVDSLFGKRSAAQAMATVVPSVSTPGGTPPRFASPALTVESMVHAAPSTTT FT SSRFSKFFNGLAGPETSKTSTPNMSNNPSPRVANTVVSPAPIPTIGSATIDKDAEGFQR FT VLAMLGRQASSTTGSPKVALSQMPQVNVNPSNQDLASVKQPSGFSPPSAVAPPPGLGNH FT NFSNDDSSFFRSLMTSDTRSVPPPPGFSTNAPKAVKSPEISAPPGLYRGLSSGASIPSA FT PPGFGYQQPSFPYSPGFPPSAYNQNRTGYGFPDTSRPPH" FT misc_feature 7227..7232 FT /note="gtaagt, splice donor sequence" FT misc_feature 7296..7309 FT /note="ctaacgttttacag, splice branch and acceptor" FT misc_feature 7370..7375 FT /note="gtaggg, splice donor sequence" FT misc_feature 7461..7479 FT /note="ctaacaaatttttgtatag, splice branch and acceptor" FT misc_feature 7533..7538 FT /note="gtaagt, splice donor sequence" FT misc_feature 7786..7798 FT /note="ctaacgtttgtag, splice branch and acceptor" FT misc_feature 9839..9923 FT /note="407 (+1) 1 85 dbj|AU007705|AU007705 Schizosaccharomy FT ces pombe cDNA, clone spc02407" FT misc_feature complement(10759..14000) FT /note="nominal overlap with cosmid SPCC1020, EM:AL023518 S. FT pombe chromosome 3" FT CDS join(10794..11000,11045..11609,11673..12413,12455..12951) FT /db_xref="GOA:O59766" FT /db_xref="SPTREMBL:O59766" FT /label=SPCC14G10.05 FT /note="SPCC14G10.05, len:669, SIMILARITY:Bos Taurus, O46606 FT , PHOSPHATIDIC ACID-PREFERRING PHOSPHOLIPASE, (875 aa)opt: FT 186, E(): 6.1e-21, (23.2% identity in 651 aa overlap)" FT /gene="SPCC14G10.05" FT /product="putative phosphpolipase" FT /gene="SPCC1020.13c" FT /protein_id="CAA20658.1" FT /translation="MQESSQEEPVHYVQWFYLSNYDLYDETSSMELTGAQSWRRFLNYD FT NNALEAKYNEIITEEVSQEPNQKNVIVGISGLHVVNLPTLTLKPLYWPSASKNDTLRVV FT RGLWMYEDTGLPVINELSDMLEEGYQEVKPYAVNWDNVLKEEEEGKDSQDDPSVLSHKR FT NKSSKELIDAMQWPLKPTSSGKYVFYEDGYRALICQGGLLSYFSKGTQSRRTSIKGMPV FT VRDFPYFEDDGFNGPKQVTDLFLVVHGIGQKRSETEERFLFTKTCNVFRSLIQIQKNIM FT KEDPLIRNDYEPQLLPICWRNKLNFNSYIKPVAGDEGRVEDEEFEENRFSIEDIEIDSI FT PAVRRLLGDVMSDIPYYMSHHKESIIKSVIREANRVYHLWKDCNPYFLENKGRIFIIGH FT SLGSTVVFDILSLQPTFVKEITIDDDESCFIFDTNGFFCFGGPVGFFLHLNQQSIIPRR FT GRGSSRYEINKNFINSDVPKSYTYDGYDRYGCLAVDSFYNIYNHLDPVAMRLNPTVDLS FT FSKGIHPTRILFTRKSSSILRMISHSNTDPVELRSYNQSLQQNKNNEPTAVVPLEPEQT FT VELETRNFRREERAKWRMQELNENSQLDYVFTSAHGVISNKYLSMLSAHSSYWSSEDLA FT CFLVVETGRNFGIANSIEQFRGKHMPRIFKGDSS" FT misc_feature 11001..11006 FT /note="gtaact, splice donor sequence" FT misc_feature 11034..11044 FT /note="ctaacgagcag, splice branch and acceptor" FT misc_feature 11610..11615 FT /note="gtaagt, splice donor sequence" FT misc_feature 11655..11672 FT /note="ctaatgttgacaatatag, splice branch and acceptor" FT misc_feature 12080..12109 FT /note="PS00120 Lipases, serine active site" FT misc_feature 12414..12419 FT /note="gtaagc, splice donor sequence" FT misc_feature 12443..12454 FT /note="ctaacaaattag, splice branch and acceptor" FT CDS join(13577..13725,13789..14000) FT /db_xref="SPTREMBL:O59765" FT /label=SPCC14G10.06 FT /note="SPCC14G10.06, len:119 SIMILARITY: to Homo Sapiens HX FT C-26, G1842163 HXC-26, (325 aa), opt:133, E(): 1.6e-08, ( FT 35.4% identity in 130 aa overlap" FT /partial FT /gene="SPCC14G10.06" FT /gene="SPCC1020.12c" FT /product="xap-5-like protein." FT /protein_id="CAA20659.1" FT /translation="MSGHTDADEIHEILRNSTTGLVHLKDYQRVKQNIVEKREKHALST FT TSTKIKKRKDALSKKVKQGIKVNKGKLSFGEDEELENDDLPLKKVEKKMFMGKDPSADT FT SFLPDAEREIRENAKR" FT misc_feature 13726..13731 FT /note="gtaagt, splice donor sequence" FT misc_feature 13771..13788 FT /note="ctgacaattcaattttag, splice branch and acceptor" XX SQ Sequence 14000 BP; 4320 A; 2457 C; 2589 G; 4634 T; 0 other; gatctcctta attgttacca ttattcaaaa atcttctata ccaaagcaag gaataagaaa 60 tataatgctg attcttggtt taaccggctc aattgccacg ggtaagttat caaataacaa 120 ttggtttaat agtggttaac ctagttaagg gaaatctaca gtttctcgcg agtttcaaga 180 gaaatatcat ataaaaatta tcgatgctga tgtgttagct agaaaggtgg tagaaccgaa 240 tacaccttgc ttaataaaaa ttcagaaaga gttcggtaat gaagtattac atgaagatgg 300 cactttgaat cgagcaaagc ttggccaggc agtatttcaa gacgcaggaa agaggtcact 360 tttgaattca ataatacatc cagcagtacg tttggaaatg ctcaaagaac tgcttcgatg 420 ttacgtacgg ggttacagca tagttatttt ggacgttcct ttgctttttg aagctaaaat 480 gcaatttatt tgctggaaaa cgatctgcgt gtcttgcgat aaaagcattc aaaagcaacg 540 tttgctggca cgtaatcctg agcttactgc agaggatgct gaaaaccgag tacaagcgca 600 gatgcctctt gaacttaagt gtcagcttgc ggacattgta atagaaaata attcggatct 660 tgagacctta tatgaaaaca tacataatgt cctaccttta atcacacctt cctatttttt 720 taccttacta tgtttaattc taccgccatt gcaaataact ttacaagtta ttgcctttgt 780 ctcgcagaag aaaaaggtat ctgaattcag aaaacatata taatcctttt ttccatattc 840 tttaatttcc tcgtttgtta tttaagccaa tagtcttaat gtttttgctt ataattagat 900 cattttcata acttatctca atatcttgcc tcgagctttc tatataaatt cacgagtata 960 tgttttatca tgatttgaaa tgagaaatta aatcttttca tgcgcataca aatagctgaa 1020 cactacaata atgattaatg tagaggttct cgcttagatt tctgggtttt aaataagaaa 1080 tcgattgcgt tccttctttc attgtctgta tacttgggta ttgaacttgt attaatcaat 1140 ctttgctaca atgcgtgact tatatttatg tcaaagaata attaaatttt ttttgttagt 1200 ttcgttgggt tagctaattt tttgattgat atatttgttc acgtatttac aatttacatg 1260 ttcgcatcca ccatcacttg aacaccttgt cagtaagtgt tcagtagcca attttctggc 1320 aaaatggaat ctggatctat tgatttggat aagggtgagt caatttagtc attacaatta 1380 tgctaactcc atgtagagat agatgaattg agcagggttt tattagagca tcctgctcat 1440 gtggaaaaag ttttaaagac cgttgagttc gataaatctg cccttcgtta tattgatgca 1500 attttagatc atcatttgaa gcagatatat cggaatttga catccaattc tcctttgcat 1560 acgctttctc tacttcaaaa aatggcatct tggaataatg gattggcatg tgttcgtgta 1620 ttccaagcta ttgactggaa cagtaaaatt tttataaaga tgctccagct acctaatcaa 1680 attcaaaatt ctaggaaagg aaataagcgt ctcaaaatca ctatatcaaa aaagcggtcc 1740 tctttactac ttcttttcat tacattcctt aggcttggta caccagaaat tcgactggaa 1800 atattaaatt caaggaaact aactactcct ttgtttaaag gtatatacaa tgatgagcct 1860 tcggttctta aggagctact tcaatgttgg ctcacttatg tgttactaga tcatgatgtt 1920 tctagggcaa caaaattatc ttattttaat gaatggtcat tgtcatgctt agcttctctt 1980 tattcaagag atgatgaaat tgatggcatt tccttatgca atcttgttca taaatttttt 2040 gtcgatgctt gtacagtacc tggtgaaggg ctttgcttcg tatcaaatgg atggcattta 2100 cagaagaagg tggatggaca atccaaaact atttttaatc gtgtcttaca gtcatttgtt 2160 ttttcattgc atgttcatac aagtacttta cagcgggaat tagtccttaa aatattaaag 2220 gcttgtccag atattacggc atcatttata gaaagaaata gtttgacctc tgaaccggta 2280 ttatcttatc aatggatttc tttcgtttca ttactccaag caatacttgg tatgggcatt 2340 ccttttcctt tttacgatgc agaaacaaga acagttcctc ctactaatat tataattgag 2400 aacatattgc cttcttcctt ttcaaagcct gtagtcctta aagcattgaa cggtaatgac 2460 aaatttgtct gttttttaac ggtgaacact ctcttagcgt cgtttaaacg tttagagtct 2520 gtattggatg aaatcaaacg ctctgaattg tctgaagata ataaagttga acttgtgtca 2580 aagatatctg atgcaatttt actacgttta cccgattctc aaacttttgt acagctttat 2640 tcttctacag aatcagattt gctgaaagaa ggactttcaa ggattttact ttattttttc 2700 acttatttcc cggaaaacat tttgaagtta aaaattgaca cctctatatt tctacggtta 2760 gatctttcgc cgggaatgtt agaccgtcca ttttcacgtt tacatgttga aaatattatc 2820 caaattcttc gatatcttcc agaagttaaa tggtttgacg tagttaggtc accttttgtc 2880 ttcctatgct tgatgtattt acaaacaagt cactcaaagc ttcgagatgc aatcattagc 2940 acgttaaacg atgtctttag ccaaactatc attttctgtc catcgctcgc tgtccctcct 3000 attttgacga ttttagcttc tcttcaacac acatctccta cgcaacataa agcagtttta 3060 gaatttttaa attcgtgtat caaccgttgt atatctcgag tttttgctta tttagatgtt 3120 tgtgtcgact gttttaaaaa gcactctgtg aattctcaaa aaaagacggc gcccgaggtt 3180 tcaccaattt cggtaacatt aattgagcaa ataccgtttt ttcttcaaaa gcgtgatatt 3240 tctgatgact caaaggatgc tgtgctctct tggttaagtg atttgttctc taaccttgtc 3300 tgtacaggcg aagatgcaaa ttgtcttttc catctattgg aaaacgtaaa cgttacagca 3360 tttgattccg attatacttt aaagcctttt aatcagctaa tgagttttat cgaaagctta 3420 gctgttcaga aacttccaga ttatgtgaat cagataggaa gcttgtctca atatctgctt 3480 tattcaacca atgatgagtt atcaaactct ggtatacaga agttcggcat gaaccttgac 3540 ttcctaccac tttatgttgt aattattacc aaaagaattg ctattatgtt gcaaagcgga 3600 gacatgagag ttaagaaatt tttggaactc atacgcgaat tagtcgaatt ttctaaagag 3660 gaaactatgg caacttcgca gtcgccaatc cggactttgc tttcagcatg cataaattta 3720 agaccatttc ttttgcaaga acaatatatt tcattcaata tggactttgc agaattcttg 3780 attgatacta atgcgtcaat aaaaggttca gttgtgaaca cgtgcgtttt ggacttttta 3840 tacaagtcat tttctgataa agtgcaagaa aactataatt taattcgtat tgcagccaaa 3900 tttatgctat tatggacaca ggaagaattt attgggtttt ccaaagcttt ggattccttc 3960 ttatcagaga atgatgattt gatttataaa aatttggatt atgttgctcc tctgcttttt 4020 gaatgtatgc agttcacttc tactactaac gcaaacatgt tttccaataa ctccatcagt 4080 gttttgctca aagctgcgat tcttaaacca acgaaattaa ctcatggtat gtttgatgca 4140 ctgaatacaa tgaagcctat tatctctgat tttactgtat ttgagcctgc cttacataca 4200 gttgaaaatt ttgatttgac cgactgcgct gatgaacaaa ttttgctgct atcttctttt 4260 gtgaatttcg tgcctctatt taggaaagtt atatggaatc ttttgttaaa taacaaagaa 4320 gctttaattc aaaagtatga attgcttgcc atattgtgtt gtgaccttgc taagcaatac 4380 gttgctgaac aatctcaata tgatttggag agaatccgtt ccttttgttc cgaggttgtt 4440 gaaaacaact tggatcttgt tttgcaaaaa tctcatttga ttgaactttt gttccctctt 4500 atgaaattga gtgatcccaa aatacaatat tatgtgaaag tgtctaatgc cttatctgaa 4560 aaatacttgc cccaaggagt attagaactt ctagttcttc ttcaaaagcg cattgacatt 4620 ccgagctctt tgagagttca aacaattatg cgaatatttg ctattctcac aagagttttg 4680 tccgatagtc cacaaattgg cttgagttta gagaaatttt taaccaactt cgaagctctc 4740 attaaaatga atgttgacat tcttagagat gaaattgata agtctacctt aaacagtttt 4800 ttggagtctg ccattgtgca cgttacttca ttttcgaatc ttcgtctttg tcttacgctt 4860 gcctttacta tgactgctga gcaatgtgat tcttcacggt ttttacaaat gattttggca 4920 catgagaaaa atcctctagc tggtgaagat agttcggatg aaatcaaagc aactatgtct 4980 gcgatcatat gtaagcttac aataataggc aaaaattaca ccttatcagt attagaccaa 5040 atattgaaac tttttaaagg tcggtatact cttcatgatt ctctactttg tgaattactg 5100 gcctactttg aaactttgga tgatattagc gtcgcaagtc gatataaagg ttgggtaata 5160 actgacgaat acgatatgat gcttcttgct cgtaaggacg gttcaggggt actggaacct 5220 aagattgctg ctaatactgt caatcaatat ccatcagagt gggagaagat tgatttgaag 5280 gtgtttgacg atttggaaac taccgaaggg ctcctttcta gttactgtag taatgaatgg 5340 aatagagaag tctatcatcc actatatgct cttggtataa cggcatccct tcttcattcg 5400 aatcagcagg tttctaacat tcaagttatt gtacaacaaa acttcctcgg tatgatagta 5460 atggggcttt ctctttttaa agaagaagca cgctttgctt gtcttaattt cctacgaaat 5520 tttataccca ttctggacga acaaaaattt agagaaaagc atttaattaa actagtactt 5580 gctagtataa ttgtgaatgt accttcttca gaaaatcggt tgagcacgtt aatggctaac 5640 ttttatgctt tcagcttgac cgtcatgatg aaaccgacac atccattatt tgtaggaatt 5700 aatcgttatt acctgcaacg tcaacatgtt gatgttacag atataccgat gtactatgaa 5760 ttactttatc catcaacaga ttacaccaaa agtgtttact ggctactgac tctattacat 5820 gctggtttac aaacaaatca ggatttaaaa atatatcttc gacgacacgt atttgaaatg 5880 atatgtactt tatacaactc atgtgtagtc aacagtgaaa tccgaacact aatcgaaaaa 5940 atattgctca aggttgtggc attgggagga ggcccaatgt tggttaaata caatgcaata 6000 taccctatgc tacaaatggt cataccaagt tttcaagaaa caaaggaaaa taccgtagta 6060 tcgaccacgt aaaaagggaa aagagaataa aagaaaaaat ttttggctgc taaaatttag 6120 ctaactaaaa ttatgggatt tgcggggttg aaaggttaga gaaggaaata ataattcatt 6180 aatagcggca cgatgataac ttgtaatttc gtatctcgac taaaattcta ataaatgtaa 6240 aaatatctgc gattgagttg acattcgtag aacgcgcaca tcgtatgaaa aatttgttgt 6300 tcaagaaaaa aagatgaagt caagggaagg aagagaagtt tcatgcacat aaaaatttag 6360 agaccatatc taatggccat ttcattttga taagtcattt ccaaaggaat aggggcagca 6420 tatatgtcgg tttcgtctag gacagcctca cgattggcaa gaatatctaa atgaaagttt 6480 gcagatcctc ctaaagccaa aggacgagag ctctatgctt gagtcagtaa aactaaagaa 6540 aaaaaaagag ggggaagata taagtgcaac aataagtaaa tatagcacta tattagtcta 6600 tacattaata acctacctgt gaagcgagtt tctgttccat ttcacgacgc acaggctcat 6660 gcaaaccgta aattctacgc atgctatcaa ggcgaatttg ttgctgttga gcctcccaat 6720 tctttaatcg actttctaga ggatgtttat tttcaacacg gtgtacagct ggaatgctgg 6780 gctctaaaac tgagactttg aagtttccag atacttcagc agctggttcg acgtcaggaa 6840 caatcttcat tataaatctg tgagatcctt caattctcta ctttgtcgag tatatgtggt 6900 ttaggatgag tttctacaat agtgaatcct ctctcgtaag cctatcgtta ccttgcatct 6960 atgttacctg ttacgactaa gattgaagtg ttttaccctt actatggagg acatactaag 7020 cttgcatgcg attactagca agatggagcc aacttaacca ctaccaccat attaaaataa 7080 cacaaaaaac catcacaatt ggtattaact cgttccaaaa aaggcgataa gatgtcgcag 7140 gttattcaat attcagaagc agatttgcta tatctatcaa aatcgccgct cataaaaaaa 7200 ccagaaaatc tgcctgaatg gattctgtaa gttagggatg ctaaataatc ttggttgatg 7260 aaaacacctt cgagaaccaa agtatggaat attggctaac gttttacagt ccggaggcta 7320 tgaaggcaga tcgtgaacgg cacattcgcc aagaaaagga aatgaaaagg tagggcagaa 7380 atatgaatac tgtgaatttc gcgacacaaa ttgattttag ttctttattt gcacttcata 7440 agttctttag agattttata ctaacaaatt tttgtataga catgatgatg atggacgaca 7500 atatcagtca gatcgtaaat tcgctaaatc aagtaagtca ttttgtttac tattttctgt 7560 cgactgttaa cataaaaaat tgtctgtatt gactatgaat ccttacaatg cacgttcaaa 7620 aagatgcggc aaaaatgtca tatggttgtt tactacagga ttgattataa tgtgaatcca 7680 ttctaccttt ttctgcatca gatatgaggt cgatgtggaa ttcgtgtttt tgacgttgct 7740 tccttgacat tgtcgataga ttccgtctct ttgttgaaat ccttactaac gtttctagaa 7800 cacgacgata ttattcttgg gccaccgaaa cttagttttg ctagcagtaa tgagaatggc 7860 aggtctgtcg gtcgccatga tgatttgctt tctttgggaa atgtgtataa cggtgtagcc 7920 tctctccgtt atcgaaatgg cgcttctgta tcgcggtcgt catccattgg tcattccggt 7980 tctactgcac catggagtag tgtaggacga cataatcgca agaaagacaa tgaacatcgt 8040 gatgagatgg aggggcttga gaaggtgatg aaacaaaggg ctggtaatac tggcccactt 8100 gttgcaaatt ctactgagga atttgaagca tggaagcgta tgatgaaggc atcctctgga 8160 gaagctggag caggtaatgt tataacaccc ggcgtcactt ccaccactgg agccccttca 8220 ggaaaagctt cgctttctag agctgcctct aattcttcaa cctctgctag agctggcatt 8280 agtgttgatt ctctgtttgg aaaacgctcc gctgcccaag cgatggctac tgtcgtaccc 8340 tctgtcagta cacctggtgg tacccctcct cgctttgctt ctccggccct tacagttgaa 8400 tccatggtac atgccgcacc cagcacaacc acttcttcga ggtttagcaa gttttttaac 8460 ggactggctg gccctgaaac ttctaagact tctacaccaa atatgtcaaa taacccatct 8520 cctcgagttg caaataccgt tgtttctcct gctcctattc ctactatagg ttctgctaca 8580 attgacaaag acgccgaagg atttcaacgc gtcttagcta tgcttggcag acaagcatca 8640 agcacgacag gctctcctaa ggttgctttg tcacaaatgc ctcaagttaa tgtcaaccct 8700 tccaatcaag accttgcctc ggtaaagcaa ccttctgggt tttcacctcc gtctgcagtt 8760 gctcctcctc ctggtttagg taatcacaac ttttctaatg atgattcttc cttctttcga 8820 tctcttatga cttctgatac tcgatcagtc cctccgcctc ccggcttttc tacgaatgct 8880 cctaaagcag ttaaatctcc ggaaatttca gcccctccag gtttgtaccg tggtctgtcc 8940 tctggagctt ctattccatc ggcaccccca ggtttcggat atcaacaacc atctttccca 9000 tattcccctg gatttcctcc atctgcttat aatcaaaatc gaactggtta tggatttcca 9060 gatacttcta gaccaccaca ttaaaaaaca gtgtccttag cacgacggtg tgatgaagtt 9120 tctcatttga ctatagtagt gggtgtgtat gcatgtatgc tctgcgcagt tgttattccg 9180 tctgcaatgt cggtaaactc cttaacatag actttgcttt atgatttctg atataaaccg 9240 gagacctttg aacgattttt ccttgtttta ggaattttta atatgtgaat taattagtac 9300 atatggcttt ttttagaatc tccttgtggt tttcagaata tactgcaaca tcgtcatttg 9360 atgaatggat actgcgtaaa atgggacaga aggattttta attaaccgtt tatgaagata 9420 atttttagga gtcgttaggt cagtttataa aataggatta atcggatgtt ttagttcatg 9480 agtctaaagt atgtgattaa gatgagtatt ttggttatac gcagttttgg gaacttgtgt 9540 cataccaagg tatagacaaa acagttcatg atagatagaa ctaaaaaaat tccacttctc 9600 aaaagtatta taaatgttaa agcatggatc tgatcaattg tttggctagc tgctggaatt 9660 ttggttgctg ctaatctaca gtcattggtt tcccggcaat gttttactaa aatttttgtg 9720 aacatgtgtt tttatggatg tgtgctcttt aaaaaattac atcttttcga gaatcaatgt 9780 gttgaaaact tagttcttta cgagaattct actctagcca aactgttatc ttttggatat 9840 acgaactaga gaaagcatct ctaaattttt agacaaagtg atactgctag ccgaaaaata 9900 atgaaaggtt gtttttcacg tttatgtttg taattaatgc gtactaatca aatcacattt 9960 tcctaatgtt tagatgtgag attggggttt ttgtaggaat atatattatt ttcttaattc 10020 atatttattt ttttaataat tggcttcact ttgactaagc gtcataaaag agatggtatt 10080 ttcaaccgat agaataaaag agttgtttaa atgggaatat acatcgctag atcttttcca 10140 gtatattttt tacaaagtgc aaaactatct tcaaagtaat atgaaaacat ataagtgata 10200 aggcgtattg caaggattac aattattttt ggacatttac acctatgaat ttgggtaaat 10260 ctatgtatga atcaaacaaa ctatagacag cagagataaa ggctctataa atgcacccac 10320 gtttactcct attaatctta taaaatttta gcacagaatt aattgtgtaa agtgataatt 10380 aaggcaggat tgaaagttgc gtttcgacaa aaaaaaatat atatttatat ataagtgtgt 10440 ataactcgta aaccaagaat gttagatgcg atcaccttta tccattatat ataaatttga 10500 tttcacaaaa actcatatca tattgtaaac aattaaataa acacggtaag catctttaca 10560 agttcacaaa aatcgttaaa ttgacttaag ctttgtaata tatttttgtc gtttctactt 10620 ttaggagaaa catactgaaa ctgacagaac tctttaagga gcttcaaaat ttttgcgaat 10680 ctcgttttat caaaatcggt tgattctgca attttgattt aagtggtacg ctattctttg 10740 tagaactgtt tacattttga tcaaacagaa cgcgaccccc aacaccgaga tatatgcaag 10800 aatcatccca ggaggagcct gtgcactatg ttcagtggtt ttacctatcc aattacgacc 10860 tctacgatga gacttcttct atggagttga ctggggcgca gtcctggagg cggtttttga 10920 actacgataa taacgcttta gaagcaaaat acaatgaaat tattacagag gaggtgtctc 10980 aagagccaaa tcagaagaat gtaactaatt ttttaatcta tatgtgagct taactaacga 11040 gcaggtcatt gttggaattt ctgggcttca tgtggtaaac ttacctactc ttactttaaa 11100 gcctctatac tggccaagtg ccagtaaaaa tgatacctta cgagtcgttc gcggtctttg 11160 gatgtacgaa gatacgggtc ttcctgtaat caatgaattg tcggatatgt tagaagaggg 11220 ctaccaggaa gtgaagccat acgccgttaa ctgggataat gttttaaaag aagaagaaga 11280 agggaaggat tctcaagatg atccttctgt attgtctcat aaacgtaaca agtcctctaa 11340 ggaattaatt gatgcgatgc aatggcctct taaacctacc tcctctggca aatatgtatt 11400 ttacgaagac ggatatagag cactcatttg tcaaggaggt ttgttatcct atttttcaaa 11460 agggactcaa tctcgaagga ccagtattaa aggtatgccg gtcgttcgag attttcctta 11520 ctttgaagat gatggtttta atggacctaa acaagttaca gatctttttt tggtggttca 11580 tggtatcggt caaaaaagat cagagactgg taagtaaact tgattttttt ttatcttaca 11640 ccggcattca attactaatg ttgacaatat agaggaacga ttcttattta ccaagacgtg 11700 caacgttttt cgttcattga tccaaattca gaaaaacata atgaaagagg atccgttgat 11760 tcgaaacgat tatgaaccac aacttcttcc gatatgttgg agaaataagc ttaattttaa 11820 ttcatatata aagccagttg ccggtgatga aggacgggtt gaggatgaag aatttgaaga 11880 aaatcgattt tcaattgagg atattgaaat tgatagcatt ccagcggtgc gaaggttatt 11940 aggagatgtg atgagtgata ttccctatta tatgtctcat cacaaagaat ccattataaa 12000 gtctgtaatt cgtgaagcta atagggttta ccatttgtgg aaggactgca atccttactt 12060 tttagaaaac aagggccgta tctttataat tgggcattct ttgggctcca cagttgtttt 12120 tgatattttg tcacttcaac ccacttttgt caaagaaatt actatagacg atgatgaaag 12180 ctgctttata ttcgacacaa acggtttttt ttgttttggt ggtccggtag gttttttttt 12240 gcatttgaat caacaaagta ttattcctcg tcgtggaaga ggctcatcaa gatacgaaat 12300 aaataaaaac tttataaatt ctgatgttcc aaagtcatat acttacgatg gttatgatcg 12360 gtacggatgt ctcgcagtcg actcttttta taacatctat aatcaccttg atcgtaagcg 12420 catcattaaa ttatcgtatt tactaacaaa ttagccgttg cgatgcgatt aaatcccaca 12480 gtggatctct cattttcgaa aggcatccac ccaactcgta tactgttcac aagaaaatct 12540 tcaagtattt tgagaatgat ctcacattct aatactgatc ctgtggaact tcgaagttac 12600 aatcaatctt tgcagcaaaa taaaaacaat gagcccacag cagtggtccc actggagcct 12660 gaacagactg tcgagttaga gactcgcaat tttcgcagag aagaaagggc caagtggcgc 12720 atgcaagagt tgaatgaaaa ctctcagttg gactacgtat ttacgagtgc ccatggggtc 12780 atttcaaaca aatatctttc tatgctttcg gctcatagca gttactggag tagtgaggat 12840 cttgcttgct ttttagtagt ggaaactggc cgaaactttg gtattgccaa ttcaattgag 12900 caatttcgtg gaaagcatat gccacgtata ttcaaagggg acagctcttg aaaattttct 12960 ttttatttta tctgacagta taccagcgag cttcatattt attagcgatg cgaagtggac 13020 aaattaaaat gaatttgatg aacattggat aatgatgatt ttttaggatc actttaatga 13080 ctttatatat tggcattcga aagatggttt tgcattcaat gaccagatac gaaaatttat 13140 tagagtattt atagcaacac tagtgattag ctagtttttt ttttgttttt aatctattgc 13200 tatttttcca aagcttgtta atacaaacga gtaattcgtt ttatttgtct ctagattggt 13260 tttaaaaagt gtctatacaa gcagttaaag attacagaat gcttcaaagt gccccacctc 13320 gttgttattc tatttaataa ccgttttgac aaatataaaa aacttatatg caacgtgact 13380 ttggcaaagt gtgcgtttat tctaggatcc ctcataggta aatgtaaaaa acatgttctt 13440 cttctacgat aaatatagta atagtcattt ctttcatttt gagatttgaa aaccgaggca 13500 aaaaaagggt attttgggta ttcaagctta tttggaagaa cgctcaccac tcacgttttt 13560 ttgaattctt catacaatga gcggccatac tgatgccgat gaaattcatg agattttacg 13620 aaatagtacg actggtttag tccatttaaa ggattatcaa agagtaaaac aaaacatcgt 13680 tgaaaaacga gagaaacatg cgctatcaac cacaagtact aaaatgtaag tgaaaagaac 13740 gagaaaagcc cgatagtatt ctaaatatga ctgacaattc aattttagaa aaaagagaaa 13800 agatgcttta agcaaaaagg tcaaacaggg cattaaagtt aacaaaggaa aactttcttt 13860 tggtgaagat gaagaactgg agaatgatga tctaccttta aaaaaagttg agaaaaaaat 13920 gtttatggga aaggatccat ctgcggatac ctcctttttg ccagatgcag agcgagaaat 13980 acgtgaaaac gcgaagcgag 14000 //