ID SPCC132 standard; DNA; FUN; 13003 BP. XX AC AL121807; XX SV AL121807.1 XX DT 11-OCT-1999 (Rel. 61, Created) DT 15-OCT-1999 (Rel. 61, Last updated, Version 2) XX DE S.pombe chromosome III cosmid c132. XX KW conserved hypothetical protein; nad-specific glutamate dehydrogenase; KW SIR2-like transcription regulatory protein; KW trichothecene 3-o-acetyltransferase pseudogene. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-13003 RA Lyne M., Rajandream M.A., Barrell B.G., Aert R., Volckaert G.; RT ; RL Submitted (11-OCT-1999) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk and Katholieke Universiteit Leuven, Laboratory of RL Gene Technology, Kardinaal Mercierlaan 92, B-3001 Leuven, Belgium XX DR GOA; Q9USN5; Q9USN5. DR GOA; Q9USN7; Q9USN7. DR SPTREMBL; Q9USN5; Q9USN5. DR SPTREMBL; Q9USN6; Q9USN6. DR SPTREMBL; Q9USN7; Q9USN7. DR SPTREMBL; Q9USN8; Q9USN8. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c132 is overlapped at the 5' end by cosmid c1322, EMBL CC entry SPCC1322, accession number AL035259 and at the 3' end by CC cosmid c338, EMBL entry SPCC338, accession number AL035259. XX FH Key Location/Qualifiers FH FT source 1..13003 FT /chromosome="III" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c132" FT /map="IIR" FT misc_feature 1..529 FT /note="nominal overlap with cosmid SPCC1322 AL035259 FT S.pombe chromosome III cosmid c1322." FT CDS join(complement(1562..1693),complement(1..1516)) FT /db_xref="SPTREMBL:Q9USN8" FT /label=SPCC132.01c FT /note="SPCC132.01c, len:548, SIMILARITY:Saccharomyces FT cerevisiae, Q12532, hypothetical 119.1 kd protein ypl009c., FT (1038 aa), fasta scores: opt: 840, E():0, (33.5% identity FT in 576 aa)" FT /partial FT /product="conserved hypothetical protein" FT /gene="SPCC132.01c" FT /protein_id="CAB58128.1" FT /translation="MKQRFSALDIAAIAAELREQVVGCRLNNFYDLNARTFLLKFGKQD FT AKYSIVIESGFRAHLTKFDRENAPLSGFVTKLRKHIKSRRLTGVSQLGTDRVLVFTFGG FT GANDQDPDWTYYLVCEFFAAGNVLLLDGHYKILSLLRVVTFDKDQVYAVGQKYNLDKNN FT LVNDNKSQSTIPHMTAERLNILLDEISTAYASPTSINEPLPDQQLSSSTKPIKVPKPVS FT LRKALTIRLGEYGNALIEHCLRRSKLDPLFPACQLCADETKKNDLLAAFQEADSILAAV FT NKPPVKGYIFSLEQALTNAADPQHPEECTTLYEDFHPFQPLQLVQANRKCMEFPTYNEC FT VDEFFSSIEAQKLKKRAHDRLATAERRLESAKEDQARKLQSLQDAQATCALRAQAIEMN FT PELVEAIISYINSLLNQGMDWLDIEKLIQSQKRRSPVAAAIQIPLKLIKNAVTVFLPNP FT ESVDNSDESSETSDDDLDDSDDDNKVKEGKVSSKFIAVELDLSLGAFANARKQYELRRE FT ALIKETKTAEAASKALKSTQRKIEQDLKRSTT" FT misc_feature complement(1517..1530) FT /note="ctaacccgttaaag, splice branch and acceptor" FT misc_feature complement(1556..1561) FT /note="gtatgt, splice donor sequence" FT CDS join(2484..2562,2620..2996,3064..3606) FT /db_xref="GOA:Q9USN7" FT /db_xref="SPTREMBL:Q9USN7" FT /label=SPCC132.02 FT /note="SPCC132.02, len:332, SIMILARITY:Candida albicans, FT O94066, transcription regulatory protein., (331 aa), fasta FT scores: opt: 966, E():0, (47.3% identity in 315 aa)" FT /product="putative SIR2-like transcriptional regulatory FT protein" FT /gene="SPCC132.02" FT /protein_id="CAB58129.1" FT /translation="MVKNTVKHVDSSKHLEKVASLIKEGKVKKICVMVGAGISTAAGIP FT DFRSPETGIYNNLQRFNLPYAEAVFDLSYFRKNPRPFYELAHELMPEKYRPTYTHYFIR FT LLHDKRLLQKCYTQNIDTLERLAGVPDKALIEAHGSFQYSRCIECYEMAETEYVRACIM FT QKQVPKCNSCKGLIKPMIVFYGEGLPMRFFEHMEKDTKVCDMALVIGTSLLVHPFADLP FT EIVPNKCQRVLINREPAGDFGERKKDIMILGDCDSQVRALCKLLGWSDELEKLIDTSVE FT TLTEEISLLSVDSTIEKNASEQKKDDNSVNPFTKIEEKKKDEVTLLVSDDE" FT misc_feature 2563..2568 FT /note="gtaatg, splice donor sequence" FT misc_feature 2596..2619 FT /note="ctaatgcgattttatcgaaaatag, splice branch and FT acceptor" FT misc_feature 2997..3002 FT /note="gtaagg, splice donor sequence" FT misc_feature 3048..3063 FT /note="ctgacggaaaacaaag, splice branch and acceptor" FT CDS join(4941..5177,5372..5595,5662..5731) FT /db_xref="SPTREMBL:Q9USN6" FT /label=SPCC132.03 FT /note="SPCC132.03, len:176 - questionable ORF" FT /product="hypothetical protein" FT /gene="SPCC132.03" FT /protein_id="CAB58130.1" FT /translation="MNPKRLRITGPEDLTDAYDTMPFRCLNGSMPPKTPLNFVFKENDS FT HVSNGVGLKKDCIESIDDLNLDDWSEQQESILLMCYENELQKPITCTPMGPICLWAPPE FT PVLRSVHNTLLKMGWSISEKKMKKKLLELLAKNKKRRTMRKLEIDTNLSFLTDVQRDSP FT IIENAPLQSPFHF" FT misc_feature 5178..5183 FT /note="gtatga, splice donor sequence" FT misc_feature 5351..5371 FT /note="ctaatcaactatttctgttag, splice branch and acceptor" FT misc_feature 5596..5601 FT /note="gtacgt, splice donor sequence" FT misc_feature 5650..5661 FT /note="ttaacattttag, splice branch and acceptor" FT CDS complement(6150..9470) FT /db_xref="GOA:Q9USN5" FT /db_xref="SPTREMBL:Q9USN5" FT /label=SPCC132.04c FT /note="SPCC132.04c, len:1106, SIMILARITY:Agaricus bisporus, FT CAB40797, nad-specific glutamate dehydrogenase., (1029 aa), FT fasta scores: opt: 2854, E():0, (46.6% identity in 1044 FT aa)" FT /product="nad-specific glutamate dehydrogenase" FT /gene="SPCC132.04c" FT /protein_id="CAB58131.1" FT /translation="MYLTKQIPHYSRIHTTQLLTVVNHRTIPFKIRGSFSNCRRYSNFA FT TVPLLERPFKNKSKHNTARASRPFSTQKMLLTKSHPPNMYKDSVFFGYRPIVFSGKQDQ FT KSKVIQCLRTERKTIPDDLVEDEVDRFYNKLGLDDYYFQMEPVSIIADHIEIIYAAKIA FT AHASHAKEELNIHVKNENEDLAIYLDSSPVTQPELDQSSAVEESISTRYLDPFKLTDPT FT AYRVESFTSVTNIDRTSTENSNIYTYFVTKCDFVDNPKKDASPDVPTDIASVSDKTFLE FT KASDNTIEMYQDVMNSVLTRFGPVVRLFDYQGRSEIRLVVGYRRGSIFQYFPSLSKLFR FT YYGLHSTRTYVEQFSNGVTIISYNFKPELFKNAAVTSINELFSQITREASLLYCLPSTD FT FQPLFVSEKLSIQEVTYAHCVRIFCEHVMNKLGPEYSSLSAILDHSNNIHAEILETIKR FT RLSTLAFTRTKIHDTIMQYPGLVHTLFEQFYLEHAINHNSTPHLHRAKSATSLADEAST FT YSITPMSATALMDLIQKTCTNEEDVSVMEMFVKFNTHLLKTNFFQTTKVALSFRFDPSF FT LDSTQYKDPLYAMIMSIGNEFRGFHLRFRDVARGGIRLIKSANPEAFGLNARGLFDENY FT NLAKTQMLKNKDIPEGGAKGVILLGKDCQDKPELAFMKYIDSIIDLLIVNKSQPLVDKL FT GKPEILFMGPDENTADLVNWATIHAHRRNAPWWKSFFTGKKPTMGGIPHDKYGMTSLSV FT RCYVEGIYKKLNITDPSKLTKVQTGGPDGDLGSNEIKLSNEKYIAVIDGSGVLYDPAGL FT DRTELLRLADERKTIDHFDAGKLSPEGYRVLVKDTNLKLPNGEIVRNGTIFRNTAHLRY FT KADTFVPCGGRPNAININNVEQLIDDHGRPAFKYLVEGANLFITQDAKSVLEKAGVIVI FT RDASANKGGVTSSSLEVLASLSFDDASFKENMCVHDGKVPTFYADYVNEVKRIIQRNAN FT LEFEAIWKGHSENKIPYTSLSNHLSTEIVKLDHDIYNYEKLWADVGFRNAVLRASIPKT FT LQAKIGLEKMLERIPESYLRAIFSTYLASRFVYQHVVSSDPFAFFDYISTEMKMLKDA" FT misc_feature complement(6483..7841) FT /note="Match to PF00208 GLFV_dehydrog, FT Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Score FT 442.07" FT misc_feature complement(8385..8561) FT /note="Match to PF00208 GLFV_dehydrog, FT Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Score FT 32.12" FT misc_feature join(complement(12993..13003),complement(12663..12989), FT complement(12117..12659)) FT /note="SPCC132.05c, len:292, Pseudogene, FT SIMILARITY:Fusarium sporotrichioides., O94197, FT trichothecene 3-o-acetyltransferase., (459 aa), fasta FT scores: opt: 787, E():0, (44.9% identity in 296 aa)" FT CDS complement(12117..13003) FT /codon_start=3 FT /label=SPCC132.05c FT /note="SPCC132.05c, len:292, SIMILARITY:Fusarium FT sporotrichioides., O94197, trichothecene FT 3-o-acetyltransferase., (459 aa), fasta scores: opt: 787, FT E():0, (44.9% identity in 296 aa)" FT /partial FT /pseudo FT /product="trichothecene 3-o-acetyltransferase pseudogene" FT /gene="SPCC132.05c" FT /gene="SPCC338.19" FT misc_feature complement(12455..13003) FT /note="nominal overlap with cosmid SPCC338 AL023781 S.pombe FT chromosome III cosmid c338." XX SQ Sequence 13003 BP; 4254 A; 2235 C; 2442 G; 4072 T; 0 other; cagtagtaga gcgcttcaaa tcctgttcaa tcttgcgttg ggtgcttttc agggcttttg 60 aggctgcctc cgcagtcttt gtttctttaa ttaaagcttc tcgacgtaat tcatactgtt 120 tacgcgcatt tgcaaaggcg ccaagagata aatccaattc aacggcaata aactttgacg 180 aaacttttcc ttccttcact ttattatcat catcagaatc atccaaatca tcatcgctgg 240 tttctgaact ttcatcagaa ttatctacag actctggatt aggaagaaaa acggtaacgg 300 cgttttttat aagtttaagg ggaatttgaa tagcagcagc taccggactt cttctttttt 360 gagattgaat taacttttca atatctaacc aatccattcc ttggttcaac agagagttaa 420 tgtatgagat aatagcctca acaagttcag ggttcatctc aattgcctga gccctcaacg 480 cacaagtagc ttgggcatct tgtaaacttt gaagttttcg tgcttgatcc tctttagccg 540 attcaagcct tcgctcagct gtcgctaggc gatcatgtgc tcgttttttt agcttttgtg 600 cttcgataga agagaaaaac tcgtcaacgc attcgttata ggttggaaac tccatgcact 660 ttctgtttgc ctgaacgagc tgtaaaggct gaaaagggtg aaaatcttcg tataatgtag 720 tacattcttc agggtgttga ggatcagcag catttgttag tgcttgctcc agtgaaaata 780 tataaccctt tactgggggc ttattaactg cagctaatat ggagtcggct tcttgaaaag 840 cagctaataa atcgtttttc ttggtttcgt ctgcacagag ctggcaagca gggaatagtg 900 gatctaattt tgaacgccga agacagtgct ctataagtgc attaccatat tcacctaatc 960 ttatagtcaa tgcttttcta agagaaactg gtttgggtac tttaatcggc tttgtagaag 1020 aggatagttg ttggtcaggt aaaggttcgt taatagaagt aggagaagca taagcagtgc 1080 ttatttcatc caaaaggata tttaatcgtt cagctgtcat atgaggaata gtagactgag 1140 atttattgtc attaacgaga ttatttttgt ctaaattgta cttttgccct acggcataaa 1200 cttggtcttt atcgaaggtg accactcgta aaagagacag aatcttgtaa tggccgtcta 1260 atagtaaaac atttccagca gcgaaaaatt cacaaaccag atagtacgtc caatcggggt 1320 cttgatcatt cgcaccacct ccaaatgtga aaacgagtac tcgatcagta cccaactgag 1380 agacaccagt taaccttcta gattttatat gttttcgtag cttcgttaca aacccagaca 1440 aaggggcatt ttctcgatca aattttgtta aatgagcacg aaacccactt tcaataacaa 1500 tagaatattt tgcatccttt aacgggttag taaaaaaata tttattactt tctacacata 1560 cttgtttacc aaacttcaac aagaaggtac gcgcatttag atcataaaag ttattcaagc 1620 gacacccaac cacttgttct cgtaattccg cagcaatcgc agcaatatct aaagcggaaa 1680 atctttgctt catttacgtc tataacacct atctaaatga atttctgcgt tacaacaaaa 1740 tgaagtatag gctctagtta gaatgtaaac atgtgtataa cgtaagtgaa actgaagcac 1800 taacaaagcg caatgatatc cgcaatatgt aataaggaaa attatagcac accattgcac 1860 cataaaacgg tgtacattag cagcattaaa attcttagcg caaatttgga ttgttctctc 1920 aaattcatta tttctttccc gacgatgatt ctttaatcgt acatttatag tcgtacatga 1980 cactgattat aaagataaaa aatagttaac taatgataaa cttataaaaa actttgacac 2040 ctaatatgtc aaactggtgt gaccaaccca ataagtaaaa ccagaaagtc aagagttatc 2100 gttgctgaat ctaatcaagt gagccgaaag ttgattaatc ataatttctg attaccccgt 2160 atctcatttt ttcaacgaca tccagaaact cttaattgaa aaagatggct ctaaatgttt 2220 accaaataac gagtactaaa gtcgaataca atagcctttt aaacagtata atgcagttta 2280 atggagcatc ggtaatggcg tttgatattt tcaacgagta aataataatg gaaatttggc 2340 gtacccacaa actttgtgca ttaacatatt gatttgttca tatctgagaa ttttaagtga 2400 tccaattttt gaaagagttt gagttgggat ttttaaggta aatcgattat tggcttgctt 2460 tggttgttct cagaaattcg acaatggtga aaaacactgt taaacacgtc gactcttcca 2520 agcatttaga gaaagttgca tccttaatca aagaaggaaa aggtaatgac ttttaatttt 2580 ctttccttga ccatactaat gcgattttat cgaaaatagt aaagaaaata tgtgttatgg 2640 ttggtgcagg gatcagcact gcagcaggaa tccctgattt tcgaagccct gagactggaa 2700 tttacaataa tttacaaaga tttaatcttc cttacgcaga agctgttttt gatctatctt 2760 attttcgaaa aaatccgcgt ccattctacg aattggctca cgaattgatg cctgaaaagt 2820 atagaccaac ttatactcat tattttatac gccttttaca tgataaaagg ttactacaaa 2880 aatgttatac ccaaaatatt gataccttgg agcgtttggc aggtgtgcct gacaaagctc 2940 tgattgaagc acatggctct ttccaataca gccgctgtat tgaatgttac gaaatggtaa 3000 ggattgtttt tgaaaaagtt aaagtgaaaa agcagaaatt ggttttactg acggaaaaca 3060 aaggcggaaa cggagtatgt tagagcatgt attatgcaaa aacaggtccc taaatgcaac 3120 agttgcaaag gtctcatcaa accaatgatt gtgttttatg gcgagggatt accaatgcgt 3180 ttcttcgagc acatggaaaa ggacacaaaa gtctgtgata tggcactggt aattggaaca 3240 agtttacttg ttcatccatt cgcggatttg cctgaaatag tgccaaataa atgtcaacga 3300 gttttgatta atcgagaacc agctggcgac tttggggaga gaaaaaagga tatcatgata 3360 ttgggggatt gtgattccca agtacgtgcg ttatgtaaac tattaggatg gtctgatgaa 3420 ttggaaaagt tgattgatac gagtgttgaa acgctgacag aagaaatatc tttactttct 3480 gttgactcta caatagaaaa gaatgcctct gaacaaaaga aagacgataa ctcggtcaat 3540 cctttcacta aaatagagga gaagaaaaaa gacgaggtga cgctgttagt ttctgatgat 3600 gaatagttca gttattcggg aaattttcta tattgtcatg attaaaacta ggagatccct 3660 atatttatta tactaagaaa acggaaattc acgattcggt ttgatgaata tttgaatcta 3720 cacatacgat tcgttttctt ttaaacaagt ttaaatactt ttttttattt cagcaatttt 3780 ataatatttc cttccaggcg tccttttgat tgcctcttaa ccatgaatca tattgctctc 3840 tttatgagtt gtatgctggg ttaaactaat gcgaaaagga taacaaaaag ggggttctgt 3900 atacgatctc gatcaaactc atgaagatgc cctcgcattt tcgtgaaaat aacttgcatt 3960 ttttttaaaa ttggcgtcca tctatatacg caatttgggt tatgagaaag ttgcgctaga 4020 ataattgata atggtttcaa atttactgca ctgtaatcta atacaatctt tgtcgaaacc 4080 ttttttctgt tcagtttgga acatatagtt ctgaaatggg agattattca ttttcattta 4140 ataaaacttt gaattatcca agaattggaa ataggaataa ttaatcaaat tgttcttttt 4200 gtagtttcat tcaagaataa tgcttccttt gaaaaactaa agcgttttct acgaattgta 4260 tattgtaaca ggggacggtg tataaaccag ttagtccatc atcataacca gttctgattt 4320 gaattttgtt cttgtggtca ttattgttca taaaatgaac tagagatgta aagacataat 4380 tcatattaca gaaaacaagt atctaagcgc ttgaacaatt atcagttaat tttagaacaa 4440 ttattaaatt tatatctatt ttatctgcat atatctatgt acctttgggt aacttatgag 4500 ttgtacgaat tactgactac atggctgtca cctcctgttc ggtttgctaa gaatttaccg 4560 attctaacgc ttccttctac ctagctatac aagattcatg aatttgatct atatgaatgc 4620 ttagcaaata aataattgtt cgaaagccag atatatgatt tataattaac gtttttagat 4680 ttgacgtcaa tagggatctt aggtctcaat ttctttgttt tgccatcttt ttatacaggc 4740 gtgttaagcg gtctggaaag aatttaaaaa taaaagggaa tgataaatcg tgttatcgtt 4800 gcaattgatc aattcttatc attttaagaa ctactcactt ttttacagta gttaataaaa 4860 gttcatttgt aatctttatc ttgattcctt tcgttgagga tcctctgaac aaaagaattg 4920 gaaatttaca cattataaca atgaacccca agcgattgag gatcaccggt cctgaggatt 4980 tgactgatgc ttacgacaca atgccgtttc gttgtttaaa tggaagcatg cctcctaaga 5040 caccattaaa ttttgtcttt aaggaaaatg actcacacgt ttcaaatggc gtaggattga 5100 aaaaagattg cattgaatca atagatgatt tgaacttaga cgactggtca gaacaacaag 5160 aatccatttt gctaatggta tgacaaagat gctgaaaaga attaaggaag gagaagcaaa 5220 cttggctgca tccctccttt tttgcacaat taaaagtggc gaattttgag gtgaaaacat 5280 gttaaatctc tcaattcgat ttacaaagat cccttcgtta tgcaaaaaca ttacaaaata 5340 acccaattta ctaatcaact atttctgtta gtgctatgag aatgaacttc aaaaacccat 5400 aacctgtact cccatgggcc ctatatgttt atgggcccct cctgagccag ttctacgatc 5460 tgtgcacaat acattattaa agatgggttg gagcatttcc gagaaaaaaa tgaaaaagaa 5520 gttgttggag ctacttgcaa aaaataagaa aagaagaact atgagaaaat tggaaattga 5580 caccaatcta tctttgtacg taaacatatc atatatgaga ggttcaatgt agtaaaattt 5640 ccatctgtat taacatttta gtctaaccga cgttcaacgg gattctccaa ttatagaaaa 5700 tgcacctcta caatcccctt tccatttcta gtagggaatt catttttctt ttcaacttcg 5760 cattgtaaat gccacttgcg ttgtgagaat ataaagtatt tggatgattt ttcttttata 5820 tgacaatggc acgtttcctt tgaatgcctg aaaggtttat tgttggtaaa atgattttgt 5880 tactgtgttc ccagtaccta gtttatatac atttatctca atttatagtt ttggttgaaa 5940 aatgaataag attttaaact attgaacagt aaattgtcgt taaatgactg agctttaagt 6000 gatagtttaa ttgaagcggg agggcctcaa tcagatttgt atgtgcataa cttatatatt 6060 tttttatttt tttatttcta tttttaatag gaagtcgtga gatcatagtc ttcacataaa 6120 tgcatgtttc atcatgtcat ttcgaaaaat taagcgtcct tcagcatttt catttctgtg 6180 gatatgtagt cgaagaatgc aaagggatcg ctcgatacta cgtgctgata aacgaatcga 6240 cttgccaagt atgttgaaaa gattgcacgc aaataagact caggaatacg ttcaagcatt 6300 ttttcaaggc caattttagc ttgcagagtc ttgggaatag atgctcttaa tacagcattt 6360 ctgaaaccga catccgccca cagtttctca tagttgtaaa tatcgtgatc aagtttgaca 6420 atctctgtgg agagatggtt gctaagagaa gtgtatggaa tcttattctc cgagtgaccc 6480 ttccatatag cttcaaattc gaggttggcg tttctttgaa taattctctt aacttcattc 6540 acgtaatctg cataaaaagt tggaaccttt ccatcatgga cgcacatatt ttccttaaaa 6600 gaagcatcgt caaacgaaag agacgccaac acttcaagtg aactagatgt tactccacct 6660 ttgttggccg aagcatcacg aatgacaatt acgccagctt tttccaaaac tgacttcgca 6720 tcctgagtta taaataggtt agctccctct acaagatact taaatgctgg tctaccatga 6780 tcgtcaatga gttgttcaac gttattaatg ttaattgcat ttggacgccc accgcaagga 6840 acaaaagtat cggctttgta acgaagatga gcggtgttac ggaatatggt tccatttcgg 6900 acaatttcac cgttcggaag ctttagatta gtgtctttaa caagaactct atacccttcg 6960 gggctaagtt tgccagcatc aaaatgatca atcgtcttac gctcatcggc taaacgaagt 7020 aattcagttc gatcaagacc agcgggatcg tagaggacac cactgccatc tataactgca 7080 atatactttt cgttagaaag tttgatctca ttggaaccaa gatcaccgtc tggaccaccc 7140 gtttgaactt tggtgagttt agagggatcg gtgatattaa gttttttgta aattccctcg 7200 acgtaacagc gaacagaaag cgatgtcata ccatatttat cgtggggaat tccacccatg 7260 gtaggcttct tgccggtgaa aaatgatttc caccaaggcg cgttacgtct atgtgcgtga 7320 atggtcgccc agttaaccaa atcagcagtg ttttcatcag gccccataaa cagaatttca 7380 ggcttaccca atttatcaac gagcggttga cttttattga caataagcaa gtcaatgata 7440 ctatcgatgt atttcataaa agccaattcg ggcttatctt gacaatcttt tcctagcaga 7500 atcacacctt tggcgccgcc ttctgggatg tccttgtttt ttagcatttg agtcttagct 7560 agattataat tctcatcaaa caaccctcta gcattcaagc caaatgcttc tgggttagca 7620 gacttgataa ggcgaatgcc acctctagca acatctctga aacgaaggtg aaaaccacgg 7680 aattcgtttc caatagacat aatcatagca tataagggat ctttgtattg tgtagaatcc 7740 aaaaacgagg gatcaaatct aaaacttaac gcaacttttg tggtttggaa aaagttcgtt 7800 ttcaaaagat gtgtgttaaa tttaacaaac atttccatga cagatacgtc ttcttcattc 7860 gtacaagttt tctgaatcag gtccataagt gcagtagcag acataggagt tatagaatat 7920 gtactggctt catcagcaag tgatgttgca gatttcgcac gatgtaaatg aggtgtcgaa 7980 ttatggttta tggcatgttc aaggtaaaat tgctcaaaca aagtgtggac cagtcctgga 8040 tactgcataa tggtatcgtg aatctttgtt cgggtaaagg ctaatgttga caaacggcgt 8100 ttaatagttt caaggatttc agcatggata ttgtttgaat gatctaaaat tgctgacaaa 8160 ctagaatatt caggaccgag cttgttcatc acgtgctcgc aaaagatgcg gacacaatgt 8220 gcataagtaa cttcttgaat ggacaatttt tcagaaacga ataatggctg gaaatctgtg 8280 gagggcaagc agtaaagtaa agaggcttct ctggtaattt gagaaaagag ttcgttgata 8340 gaagtaacag cagcattctt aaaaagctca ggtttaaagt tatagctgat aattgttaca 8400 ccattgctaa actgttcaac gtatgtacga gtggaatgca gtccataata acgaaataac 8460 ttggacaaag aagggaaata ctggaaaata gatccacgac ggtaacctac gaccaaacgg 8520 atctcggaac gtccttgata atcaaaaagg cggacaacag ggccaaacct tgtaagaaca 8580 gaattcatta cgtcttgata catctcaatc gtgttgtctg atgccttttc caaaaatgtt 8640 ttatcagaaa cagaagcaat atcagtaggt acatcgggag aagcatcttt ttttggatta 8700 tcaacaaaat cacatttggt aacgaaataa gtgtagatat tggaattttc agtactggtg 8760 cgatcgatgt ttgtgactga ggtaaaagat tccactcgat atgcagttgg atctgtcaat 8820 ttgaatggat ccaagtaccg tgtagagatg ctttcttcga cagcgctaga ttggtcaagt 8880 tcgggctgag taactggaga actatctaag taaatagcga ggtcttcatt ttcattcttt 8940 acgtgaatgt tcaattcctc tttcgcatgt gaagcatgcg cggcaatttt cgcagcataa 9000 atgatctcga tgtggtccgc aataatcgaa actggctcca tttgaaagta ataatcatca 9060 aggcctagct tgttgtaaaa acgatccacc tcgtcctcaa ccaaatcatc gggtatcgtt 9120 ttacgctccg tacgtaaaca ttggatgact ttgctcttct ggtcttgctt cccagaaaag 9180 acaatgggtc tgtaaccaaa aaataccgaa tccttataca tattaggagg atgacttttg 9240 gtaagaagca tcttttgcgt agagaatggg cgagatgcac gagcagtgtt atgttttgac 9300 ttgttcttaa aaggtctttc cagtaaagga acagtagcaa aattactata tcttctacaa 9360 ttggagaagg atcctctaat tttaaaagga attgtgcggt gatttaccac cgtcaataac 9420 tgggtcgtat gaatacgact ataatgcggt atctgtttag ttagatacat cttgaacaat 9480 ctgaatcttg tctctttgac aagaaagcca aaataggagg ttggcagtaa atttctataa 9540 agattgagga agtgagatca caaaaaatac taccaacttc ttataattat ataccttgta 9600 tcccgagctc tccacctcac aggcttgacc gacggatacg taatgcgatt ttaggtaaag 9660 ggcctaccta aattaacgaa tgtttttcca attatattcc aaagacggaa gaaactaggc 9720 tggtacaaaa taaatgtccg caaagtttca ctgtacacct gatgttatac tgcacggcta 9780 tacttatgtc tcatggatgc gcattttagc cagtacatat atagtaaagg aaaagaaaga 9840 tggaacggaa aaacaaaata ctagatcgtc taattataaa aaagcagcaa ctttgtgaac 9900 ggtttaaaag aacaattgat ttaaatacgc agggcaatca aacaattttt gtaaaacagg 9960 tgacaagagc caagtgacaa aacgaaagag gcatcataca gcgtctagaa gaaaaaagtc 10020 aaggaaaaag aaggatggct gccccttcgt ctcgaatatt tataaacgtt gttcatagta 10080 atagactcca acgttttata tttcaaatta atgaaaaaaa aatgaaatga attcttctta 10140 caataaatta aaatcagatg ccaacggata acgtggggta agagaataaa ctgactgaga 10200 aaacaagccg tgcaaatcgc taaaaccata gtaggatgca gctttcatta ggcggaacaa 10260 aaatattgtt aggccaaaat ccaaaaaata ttgactcaac tgacatcagt cggcgaaaca 10320 attaattcca gagtcataat cttaaattct agtgataaaa aaaagtatgc gcaactcctt 10380 taggggtaga tttgatcacg aaatataaac atttaagcga tattttggcc agttagcaaa 10440 tttagacaaa cattttaatt taatcaagat aaaaacacga tgctgatttt gaaaggcgta 10500 aataatgaag gtggcagaaa tttccaaaag gctagaatgc aaaaggagaa aatttaaatc 10560 aaaaaaatga aaccaggtac gtaaatctag taacgattca aaacagctgt caacaaacca 10620 atttatcatg ataacaacac gatgtttcga gactgaaaaa aattttaacg ccgcttatta 10680 aatttttttc cttatagcta ccaaaagttt ctggggtttt aatgtcaaac atttttttca 10740 tcgagttact agacatggga taaacagtag cattaattca aaacctagaa tttcttggca 10800 aatttaaata gtgtttaatg ctccatatat tgttttgagt tctgtgactt aatcatgctg 10860 aatacacgaa aaaaggcttg cagctttaaa gtcttactac acagaccagc taagaatgga 10920 gttttaagtt tttaataact gagaacaagt aaagctttgt gaaacatgag ttattcacaa 10980 ttggacgcgt tatttccgta aattttagga tttgacgatg aagagtttaa aatatttgtt 11040 taggctctaa tgtgtttgtg atattaagga cttatcaatt gttgaaatat tattcatcat 11100 ttttatacgc tattatgaat tttaaaatca gaagctgctt gagggtttta gagatgtgtt 11160 gtgaagtggg agaaatattt tcgcgttgat aagtgttagc cttaataagt tagcacacac 11220 tatttatgca tacacaaacg tattctgtag aacttaatca aaagtgtgtt taaacgcata 11280 attcttctta aaatctttca atagagaatt aaaatataaa agaagtttct gaaatatgtg 11340 atttaaattt caatattttt ttagtagatg aactagcgta caattcacga agacgttaga 11400 atacgctaat ttttccaagt gtgatacttt atatctagga ataactggta catccatgcg 11460 taatttgagc ctcaatgtta gtactgttta gatttcgatc agcttttcat agtcattagc 11520 acttcatttc taatatacct attacttttt atagaaagaa agaaattgtc tttatatatc 11580 ttgattggcc tacctgtcta ctcattacca tttatgtatg gcccctattt tatttatcaa 11640 ataatgaatg ataatgtaca atacactatc ctgatatagt gatatgttac tatatgttaa 11700 aaatattcga attttacaaa tgtaaaggat tggagaaaag cttgaagttt actagaaaag 11760 gaaaatgaaa ttttttagaa tcaaaattcc ttaaaactgt aaatctaaaa attatttaat 11820 gattcaatat ctactttacg ctcatatttc ttaataatga gtaagtcgat tgggagtagc 11880 attaatcata gacatcgact caaaaaatag aatagttgtt gatattttat taagagttct 11940 taaaacttgt atcaaaaaat aaaagaaagt aattataagt tctcaattga tattgtggtc 12000 aagttgagtc attacgatga ctttaaaaaa aaaaatcaac cgaatataaa tttacacact 12060 atcacgcatt gtttcccaat agcaccgtgt cctctggttt tttaataacg ttgcagctat 12120 ccgatgtatt tcgcatactt agagaactct tcatcaattc tcaatttctt catgtcctcc 12180 tcccttaaac aaatagcaac tgtaattcca ccttccaagt ctttcggcat aaagtaaatc 12240 aagccctcta tcgggataaa ctggggtctc cgtacagcct ctggttttcc caatcctagg 12300 ttaaactcaa gctcataact attcaactta gcccatgaac tcaaagcaat atcggtattt 12360 ggatcaaggt ttgagcaaaa ggagattaga tttttatttg gactacgatg aattaaagtc 12420 gcaagtgcac tcgattcata agcccgtgtt tttggatcca aagctgaacg aagcttcgat 12480 gcaaggccac ccaaaggctc cttcatcaac tcttcaatta cacatctctg tgacttcatg 12540 ttaagcatta gtcctggata cgttggtgaa atattgcagt actgccgtac atcaacagca 12600 cgacaaagtg tggatgtggc tgtagggttc aatcgagaaa tgcagcagcg aataatggct 12660 taccagacga atgtggtaag ggaatcgtcg gtggatatat attctgaggc aaacgacgag 12720 gggagagttt ttgtagccag tgttttaaga gcggtgagtg agttatggtc gaagcaaaag 12780 taactccaaa tacatttagg aggaggagga tgtgatttat caacgctttc aagttcggaa 12840 taaaaaggag gtgacttcaa aatgaaatga tccatctcag aacctggttc gtaagagtct 12900 tcgagtaaag ggataaggtt gtaacgggga aggttaccat cgctagtaaa tggttcattg 12960 caacaagctt tagaaaagag gttgataacc taaccttggc cgg 13003 //