ID SPBPB21E7 standard; DNA; FUN; 21862 BP. XX AC AL732457; XX SV AL732457.1 XX DT 15-MAY-2002 (Rel. 71, Created) DT 10-FEB-2003 (Rel. 74, Last updated, Version 2) XX DE S.pombe chromosome II BAC pB21E7. XX KW . XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-21862 RA Wood V., Rajandream M.A., Barrell B.G., Harris D.; RT ; RL Submitted (15-MAY-2002) to the EMBL/GenBank/DDBJ databases. RL The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; Q8NIL3; Q8NIL3. DR GOA; Q8NKC0; Q8NKC0. DR GOA; Q8NKC1; Q8NKC1. DR GOA; Q8NKC2; Q8NKC2. DR REMTREMBL; CAD31743; CAD31743. DR SPTREMBL; Q8NIL3; Q8NIL3. DR SPTREMBL; Q8NIL4; Q8NIL4. DR SPTREMBL; Q8NKB9; Q8NKB9. DR SPTREMBL; Q8NKC0; Q8NKC0. DR SPTREMBL; Q8NKC1; Q8NKC1. DR SPTREMBL; Q8NKC2; Q8NKC2. XX CC Notes: CC This cosmid was originally thought to belong on chromosome 1 CC left end. It is now known to belong on chr2 left end. Annotations CC and systematic identifiers have been updated and old systematic CC identifiers obsoleted. CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC BAC pB21E7 is overlapped at the 5 prime end by BAC sequence pB8B6. XX FH Key Location/Qualifiers FH FT source 1..21862 FT /chromosome="II" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="BAC pB21E7" FT /map="IIR" FT CDS complement(<1..1307) FT /db_xref="GOA:Q8NKC2" FT /db_xref="SPTREMBL:Q8NKC2" FT /gene="eno102" FT /gene="SPBPB21E7.01c" FT /gene="SPBPB8B6.07c" FT /protein_id="CAD31742.1" FT /translation="MTTIQKIYSRSIYDSRGNPTVEVELTTELGTFRSMVPSGASTGEW FT EAKELRDNDKNKWGGKGVTIAVHNVNNIIGPALVKSDIKITDQRGIDEFMIKLDGTNDK FT SKLGANSIVGVSMAVARAAAAFLKIPLYEYIGKLAGSKTTECIPVPSFNVLNGGRHAGG FT DLAFQEFMIMPIKAPTFSEGLRWGSEVYHTLKALAKKKYGASAGNVGDEGGIAPDLTTA FT EEALDLVNEAIKEAGYDGKVKIGFDVAASELYNGKLYDLDFKSEHPKPENKLDYKKLYE FT KYSALIEKYPIVFIEDPFSEEDWGAFSYMSSKTKVEVIADDLTVTNVKRLSKAIELKCA FT NALLVKINQIGSLSETIDAANMAKKAGWGLMVSHRSGETDDSFIAHLAVGLEAGQMKSG FT APCRSERLAKYNELLRIEDNLGDSAIYAGTRAADYI" FT misc_feature 1..100 FT /note="nominal overlap with SPAPB8B6 S. pombe chromosome FT 1" FT CDS join(complement(2780..2866),complement(2214..2768)) FT /db_xref="PSEUDO:CAD31743.1" FT /db_xref="REMTREMBL:CAD31743" FT /pseudo FT /gene="SPBPB21E7.02c" FT /product="pseudo SPAC5H10.03; frameshifted (single)" FT misc_feature complement(2757..2804) FT /note="The region is very well covered with both positive FT and negative reads (5 very high quality positive and two FT good negative reads) and the consensus has a very high FT confidence: deh" FT LTR 4867..5199 FT /note="783 (+1) 21 268 Tf1-type LTR" FT CDS complement(6330..7175) FT /db_xref="GOA:Q8NKC1" FT /db_xref="SPTREMBL:Q8NKC1" FT /gene="SPBPB21E7.04c" FT /product="putative O-methyltransferase; possibly involved FT in homocysteine metabolism; similar to S. pombe SPBC119.03 FT (paralog)" FT /protein_id="CAD31744.1" FT /translation="MFAQALHWLTTSKLRYALALPFLFFILYTKTKKSKEQELENYIFS FT LPREKLDQIRGKPDEVINVIDEYVEQGHFLMNIGKLKGKIISEKIQQVKPKVMIELGGY FT VGYSAILFGKQLTDPSAHYYSLEVNPKFAKIASKIIDLAGLSNKVTIIVGKATDSLVEL FT RRSLPNVIPSFEYLDFVFIDHWKDLYVPDLRVMETLDLIGQGSIIAADNILRPGVPEYV FT KYVQGSLDYRKEYDSTVSNVNGPQFIGKWNIIYKSKTIKVDDGKREKDAVEITEYIEAK FT " FT CDS 8503..8886 FT /db_xref="SPTREMBL:Q8NIL4" FT /product="hypothetical protein; sequence orphan" FT /gene="SPBPB21E7.05" FT /protein_id="CAD31745.1" FT /translation="MVKKFQSKLINLQFNIILTFFVYEWNHDITCLNFKVKKRRGDFYV FT INERFFIKYIIKKNKNPQNLTKSICNSKTSINSMRQYLATINKKLRAFVQTFLAIGGYY FT SITTQIVKIILITHPVLLCQCSS" FT CDS 10016..10513 FT /pseudo FT /gene="SPBPB21E7.06" FT /product="pseudogene; fragmented copy of S. pombe FT SPBC2A9.02" FT CDS 11865..12755 FT /db_xref="GOA:Q8NIL3" FT /db_xref="SPTREMBL:Q8NIL3" FT /gene="aes1" FT /gene="SPBPB21E7.07" FT /product="enhancer of RNA-mediated gene silencing (PMID FT 12034844); phrenazine biosynthesis-like protein; similar to FT S. cerevisiae YHR029C" FT /protein_id="CAD31747.1" FT /translation="MTEHSFKQIDVFSNKGFRGNPVAVFFDADNLSQKEMQQIAKWTNL FT SETTFVQKPTIDKADYRLRIFTPECELSFAGHPTIGSCFAVVESGYCTPKNCKIIQECL FT AGLVELTIDGEKDEDTWISFKLPYYKILQTSETAISEVENALGIPLNYSSQVSPPVLID FT DGPKWLVIQLPNATDVLNLVPKFQSLSQVCKNNDWIGVTVFGELGKDSFESRSFAPLIH FT VNEDPACGSGAGAVGVYIGSSQKTPTSLSFTISQGTKLSRQAISKVSVDVSSNKSIAVF FT VGGQAKTCISGKSFI" FT misc_feature 13784..13981 FT /note="possible rearrangement here. Possible N terminal FT Adenine deaminase fragment" FT CDS join(14006..14273,14273..14778,14797..15051) FT /pseudo FT /gene="SPBPB21E7.08" FT /product="pseodogene; 2 frameshifts; similar to S. FT cerevisiae YJL213W" FT misc_feature 14241..14297 FT /note="It is covered by 10 reads (3 forwards & 7 reverse) FT with no disagreements between any of the reads. Most of the FT reads are very high quality; deh" FT CDS 17979..19061 FT /db_xref="GOA:Q8NKC0" FT /db_xref="SPTREMBL:Q8NKC0" FT /gene="SPBPB21E7.09" FT /product="putative L-asparaginase; similar to S. pombe FT SPAC186.03 and SPAC977.12 (paralogs)" FT /protein_id="CAD31749.1" FT /translation="MWSSIISFLFFSVALCQPLLFQKRSSNVSDFISFNASLPNVTIFA FT MGGTIAGYASSSTETVDYAAGSVGIATLVDAVPAIKNFSNIRGVQVTNVGSEELTPANV FT LNLTQLILAEVAKPDVHGIVVTHGTDSLEETAIFLDMTVNTTKPIVVVGAMRPSTAISA FT DGPMNLLNAVVVAASNRSIGRGTMILLNDRIGSAFYTTKTNGNMLDTFKSYEAGFLGMI FT LDQRPHFFYSPATPTGKVHFDVSNTTELPAVEILYGYQGLNPNLAKAAVDLGAKGLVLA FT GMGAASWTDPGNEVIDGLISNQSIPVVYSHRTMDGFSDYYYNGIPAYFQNPQKARYMLM FT LSINAGYSIQNITDIFSLEY" FT CDS complement(21755..>21862) FT /codon_start=1 FT /db_xref="SPTREMBL:Q8NKB9" FT /product="amino acid permease; duplicated in S. pombe" FT /gene="SPBPB21E7.10" FT /protein_id="CAD31750.1" FT /translation="DHTSRLWINWIFQLAYELMKILTKKMRHLVDLNMF" XX SQ Sequence 21862 BP; 7361 A; 3677 C; 3579 G; 7245 T; 0 other; ttgatatagt cagcagcacg cgttcctgca tagattgcgc tatcacctaa gttgtcttca 60 atacgaagaa gctcgttgta cttcgctagc ctctcagatc tgcaaggagc acctgacttc 120 atctgcccag cttctagccc aacagctaaa tgagctatga aagagtcatc cgtctcaccg 180 gatctatggg ataccatcaa tccccaacct gctttctttg ccatattagc agcatcaatt 240 gtctccgata aggatccaat ttgattgatt ttaactaaaa gggcgttggc acattttaat 300 tcaatagctt ttgataaacg tttcacattt gtcacagtca aatcatcagc tataacttcc 360 actttcgtct ttgaagacat ataggaaaat gcgccccagt cttcttcact aaaggggtct 420 tcaataaaaa caataggata cttttcaatt aaagcagaat atttttcata caacttttta 480 taatcaagtt tattctcggg ttttggatgt tcactcttga aatcaagatc ataaagttta 540 ccattataca actcagaagc agcaacgtcg aatccaatct taactttccc atcgtaacca 600 gcttctttga tggcttcgtt aaccaaatct aacgcttctt cagcagttgt taaatccgga 660 gcaattccac cttcgtcacc aacattgcca gcggatgctc catatttctt tttggcaagt 720 gcttttaacg tatggtaaac ttcacttccc caacgtaacc cctccgaaaa ggtaggtgcc 780 ttgattggca tgatcataaa ttcttgaaaa gctaaatcgc caccagcatg tcttccacca 840 ttcaacacat taaatgatgg aacgggaata cattcagtag tctttgagcc agccaatttg 900 ccaatatatt catataaagg tatctttaaa aatgcagcag ccgcgcgagc tacagccatt 960 gagactccaa ctatactatt tgctcccaat ttagatttgt cgttcgtccc atccaactta 1020 atcataaatt cgtcaatgcc tctttggtct gtaattttaa tatcagattt aaccaaggca 1080 gggccaatga tattgtttac attgtgaacg gcaatggtaa cacccttacc accccattta 1140 ttcttgtcat tatctctcaa ttccttagct tcccattcac ctgtagaagc ccctgatgga 1200 accatcgatc taaaagtgcc aagttcagta gtgagttcaa cttcaacagt aggatttcct 1260 ctagaatcat aaatacttct gctataaatt ttttgaatcg tcgtcatttt taatataaaa 1320 aagttgtttt caaaattctt ctgaagtctg tgatttggat agtaggtata aatatatata 1380 tatatacaca gcttggcagc gtaatttata gaattatgtc ataaacgaat cgcccagcct 1440 gtggttaata cgtgtaaatg ctccatacat caagggatat actactacta ccattcgaaa 1500 agtttattaa aaatcgtata ttcataattc cttatgggaa aaatcaatag atttttaatg 1560 agatcatcgt agtacttcta ttctaagaaa ttttaaaaat tattaacgtc tatatatcgt 1620 ttggaaattt ttaaacatct ataagaataa actaaagtta tgaaaagaga acatgcttga 1680 ttacaaagta aagctacctc aaaaagagaa agtaaaatgt aaacataaat taaaactcat 1740 gcgatttaat taggtgatgc aaacagaggt ttcatcatat atacatgtac ataataataa 1800 atccgtgcat tacatacacc ttgctataga atataggaac taaattcaag cctcagggtt 1860 gatgataata ataatactat cgtataatta atcgaaatat acattttaat agtaacaact 1920 ttcaaagctc cctcctcatt aattagttca aaaatatttc attcactaag cgtttttgct 1980 cgttaaaatt cttttggaca aaaagcaata ataatagtag acaaagtcga tctctctgtc 2040 tgaatgctga atcttaccat acattttttc tcatgcaatt ctattacacc atcaaccttt 2100 atacaaacta gtgtttctta taagtttctt ttatacattg aaccaaagta gaaatggtat 2160 aatattttta tttgatttga tttgatcttt taaactttta ctaaactaac catttaattg 2220 tctataagcg ggattaactc ccattgaaaa cctgtatgac agaggttgta ttttctgatt 2280 tcacaatttc taaacacttt ttcaggaggc ataaagttca tattatcttc aggtcgttgc 2340 tctctcagca aaaagcgaag gtagacgcta tgagttacaa ctacaatatt tttctcatgg 2400 agactagcta aatgtttcaa cggtttttga gcacgacaat aattctcatc ataagtagtt 2460 ccgtataatc ctcgtctcag tggatatata tcatcgtagc aagaactgaa atcataatca 2520 gggaaaagct tttccgtgct acttaaatcc attgcacagt cgcaaggcca atttccagat 2580 tcttcaaaaa gtggagatat ttttataggc actggtagct ctttgtgaat gtaactttta 2640 aacgaaattt ccatcgtttg caacgtacgc ctcaagggag agcatactat tacatcaatt 2700 ggaattggat tgtcaaccaa ccaattatga agggcttccc attgttttat accaacttgg 2760 ttaattctgg gtcccgaata cggtgatttc ctggaggccc aacgttgtgt tcagcttgtg 2820 catgtctaac caaccaaata actttttctt ccaaattttt gtccatatgt atatgctatt 2880 tagtactact taaacaaacg tgtataattt ttctccttta tatatttagt acaaggtcca 2940 acttactaat aatgttttca taaaccaaat aattacgttt gtaaaataag ccattacaat 3000 aaattacgtc taatattggt actgataagt agtaattcat tatcacctag gaggtatagt 3060 atacgaaatg aaaaagtact agaaacaaat atatatatat attgcttact tattaatttt 3120 ttgttaagac aagtttgtac tttcatctaa tgagatatgc agaagcttaa taaatcaagt 3180 tcaaaaggta tgataaaaat atatacaagt attggtgaag gtatacaata agttgtggtt 3240 gattgttgga gccttataaa attttttttc ttaattaatt aacaatttat agggaaaaat 3300 aatattgaaa ctgaggaagc tgaagattca gctggaagag gatcaactta tggatttggc 3360 ccatatggcg gaggagggtt ctcttcaaaa tcttcggggg aagaagccac tacaggagat 3420 acaaaaaagt tgaaaggaga agtcgaagaa ggaactggaa aactgttaca ttctaagaaa 3480 cttgtcgata aaggtgaaag aaaggagagc gaatagccaa aaaaccatgc aaggaacatc 3540 tatttatctg caattcctat tttattgatt ttgtaaattc ttgaatttag ttcatcttta 3600 aatttctttt cttttttttt gttgtgaacg aaaaaatggg actcttacct cctagctttc 3660 agatgtttcg agtagtacat tttgttgctt aaatgaatat tcagatttag gaattgatgt 3720 aaataaatgt tttctgagta agaaattatt atgatagata agaaattaat aaaatagggc 3780 taaaaataat tttaacagtt ttaacgattg tacgatatgc tattctctta aatcttcttt 3840 ttgccactta atatcctttc ttcatggtac ttcctataat acaaaagaga aattgaatat 3900 ttcactcctt gtagcattaa atcaaatgaa aaattcgata caaaagtaaa aatagcttag 3960 aatgtttttt ctggttaata taatcctctt taggtgattc attggattca tccatgaatc 4020 cacgattgcc tcctgctcca taaccatacg tagaaccact accagcagaa gatagtgatt 4080 gatatttcct tattgaatcg caatttctaa ctagaatgat actagtaaac ttttcatgaa 4140 taaaaaatac actatattat agatcacatc acctttaaaa cctattgtac acattttatt 4200 cctcatattt ttgaaattca atgaggaagc aagagtaaaa gccaaaataa acacttacca 4260 tctgattgag tatcaggtgc gcttgctgta tcacgaaaac cagataagtc ctcgggtata 4320 tctttcccta ggtactcaga taaattggat tctgcattat tattgtatat gaagtcaatg 4380 tttttattgt tagatggttt tgattcacta cttgacgacg acgaatctga tgaatatcca 4440 cggtcacctg ctaaaccgaa tccataggta gatcccgtgc ctgcagacgc acgagtagaa 4500 tagcgagaaa gatatgtgtc actttcaagg tttgaggatg aagaaccttt aatttgtcaa 4560 taattatgaa agatttcata tatactaatt gttttagaaa atacgcacgc ataacataaa 4620 ttcaaattta aaattattat acagctcctt taaagtaata aatcaagaca gttgcaagta 4680 aaaagagaag cttaatttat attttatata ctgattacaa cgttacgtta tgttatggag 4740 taaaagcact ccgcattttc aaagttactt gcgaaggcgt gcattttaaa aatgatgtca 4800 gtaaatatta ttcatgtatt tttttattgc ttcaacaaat taagcgttat tgatggttaa 4860 atgtcagcaa tactacacta cgttgcgtat cactatatgt catatgttgg aatactagtt 4920 aagatccgcc tattgatcat aaggagtaac tatccgtcta tatacattga tatccgttga 4980 taacaactat tagaaagatt ataaatagag ctactgctca acttcgttcc tcagttcagt 5040 tatgagctat atcggtgacc gatactaaca gacttataac aataaatata cattgttact 5100 taacataccg cataccacta cattgtagct cgcaagtaaa actcaccgca gttctacgta 5160 tccttaaaac cagatgccaa actgcgtagc taacattaaa tatgtttttt aaattaatag 5220 aaaataagat gtaaaacttt accactgtaa aatccttaat aatcattatt actgattagg 5280 aagaaaggta atgagacaat aaaatcggct accagtgctt tcaaccaatt gaattaggag 5340 gtttttattt cccattcatg actttagtgt tagttcttat gaaactttgt acctagctta 5400 gtttagaagc tctttaattc accttcgacg aattgcagta ctccgtggag tttatgtaat 5460 gaagtttgcg aagtgataca tgccacagac ttttttgagc catattataa ctttcatttt 5520 caaatgaatt gagaatggta caagtaccca ctaatgtcca tgtaccacca tcttcaacat 5580 tccgtatgaa ctttaaacac atttagaaaa ggagtgattc tcttaatatg ctcagtagca 5640 ttcagtaccg acgctactgc cgaaacgatg gaaaatgttc acacaacgat catcatgttt 5700 attttatatg ctttcgacta caaaatcctt agtccttaga gttttggttg ctttaaggta 5760 atggcactaa aattttcgac tcaacttcag aagtataatt gggaataatg tctatttatt 5820 tgtatactct gatcaagctc attgtatgca tgggctcttt acaaatcatt aaaaaagatt 5880 tggactattc caacaaaact tttagttcat cataatatat atccaatttt acagttttaa 5940 cgtttcctca ttgtcaaatg taactttgtt gtgtcgactc gtactaatat ttataacgat 6000 tttagaaaaa taaacgactt ccgtactcaa attttcttct gctccaattt gcaactctat 6060 gtatgaaaat ttaactacca aattaatgca tttcctagat tttaattgta attatatgat 6120 tcttaagttt tccgataata aacaataccg gccagcaact taaaatagtg gttactcgct 6180 tttatttcat aactggcgta agggttataa tgcatagaac tcgatttgca aataagatac 6240 catttaccca aaataatgtg cataaaaatg tattctcttt tgcttgatta tcagtaaaaa 6300 aaaactatac tagaaatact ttttaatatt catttcgctt caatatattc ggtaatctcg 6360 acagcgtctt tttctcgctt cccatcgtcg actttaatag ttttcgattt gtaaatgata 6420 ttccacttcc caataaactg aggaccgttg acatttgaaa ctgtactgtc atattcttta 6480 cgatagtcta aggatccttg aacgtattta acatactcag gtactcctgg tcgcaaaatg 6540 ttatctgcag caataatgct cccttgacct atcaaatcca gcgtctccat aaccctgaga 6600 tcaggaacgt atagatcttt ccagtgatca ataaaaacaa aatctaagta ttcgaaactt 6660 ggaatgacat tcggtaggct ccttcggagc tcaaccaacg aatcagttgc ctttccaacg 6720 atgatagtaa ctttattaga taatccagcc aaatcgatta ttttactcgc aattttagca 6780 aactttggat tgacttccaa gctataataa tgagcagatg gatcagtcag ttgttttcca 6840 aacagaatag cagaataacc aacgtaacca cctaactcta tcatgacttt tggcttcact 6900 tgttgaatct tttcacttat tatttttcct tttaactttc ctatattcat caggaaatga 6960 ccttgctcaa catactcgtc aatcacattt ataacttcat ctggttttcc gcgtatctga 7020 tcaagttttt ctctgggaag tgaaaatata taattctcaa gttcctgctc cttggatttt 7080 ttagtttttg tgtatagtat aaaaaataag aaagggagag ctaaagcata acgtaatttg 7140 ctagtggtta accaatggag cgcttgagca aacatattta ggcagcaaat cgataatatt 7200 gaagagttgc ctaatactaa taaagattta ggctaatata tatgcaattt tggtaacgga 7260 tgaaatgaca tcggataagc cacgtaactt aattagtgaa attgtgggca gactgactaa 7320 ttctctacaa taaaagcacc tatgctgcat gtatgagaaa aagtttttcc gttacagatt 7380 taaacatatt ttaacaatta cttacacatt ttcatacatt tatcaacttt attgttatat 7440 tcatgcggtc tttacctctt cgacgctgta tactggaaac catatcttag aatgaggctt 7500 atcagatgcg cagcaaaatg aggcgtgata aacatttatc tgatttcgat caacattatt 7560 tcccaagatc agcagcagaa ggattaatct gtctaaaatc tagtccctcg atttttgaaa 7620 aggatcaaca agtcttctag accctccaga atttcagagc tgtatgaagg atttcttgct 7680 aacacgttgg agagtttcat caatagatat ttacaattag acatgcattt gcatgctacc 7740 ggctgcacca atggtgttaa gctatgtttc tcagaattct tcttttacta tatgctgatg 7800 catgaaaata gttgtaggca ataaaagaga agtactagta attaatataa ctacatatta 7860 ctgacagaat tgaaaattca taatctcagt taagataggt gataaacaac gaaaaataaa 7920 taaatatcat atgagatttt ttaaatctaa ccatattaca tatccaaatt gacataaaac 7980 gtaaaataat aaatctaata aagtataact aattttgctt ttactgatgc catcaagatc 8040 gtattgcttt cacgacttcg tgctgatata aacatgaact tttgaagttt gttgcaattg 8100 aagttaaaat atatccaaaa atggttattt tctgaatcat acacttaaca attaaaaaac 8160 ggcttagcat caaaataata atataattta aacggaattc accagcgtca gaaccattac 8220 ctactaatat ttcttaatga tgcggtgtat cgcgtaactg aaatattgag tcatttatat 8280 tttttaatta tattataagt ctttatcaag tgcattttaa tacctggata actattgcaa 8340 cgtactttgc tttacgtctg taaatactgc taaattttta ccttctcatt tatttaattt 8400 cagtagagtg atatattaaa tcttttgcct tcttctgggc tttccaatat tcagtttatt 8460 attaccttat atcatcatat ttgtcaggct tagctgaatt tgatggtgaa aaagtttcaa 8520 agtaaactaa ttaatttaca atttaatatt atattgacct tttttgtgta tgaatggaat 8580 catgatataa cttgtttaaa ttttaaagtt aaaaagagac gcggtgattt ttatgtaatt 8640 aatgaaagat tttttataaa gtatattata aaaaaaaaca aaaaccctca aaatttaacg 8700 aaaagcattt gtaactcaaa aacctcaatt aattccatga gacaatacct agcaacaata 8760 aataagaaat tacgtgcttt cgtacaaact tttttagcga ttggtggata ctactcaata 8820 actactcaaa tagtcaaaat aatacttatc acgcacccag ttttgctttg tcagtgctcc 8880 tcataaacgt tttggtatta cgtatcaatc actagctgtt taccgtacct gcagttataa 8940 cgcttatgta cgttagctta gatagggaag taaggaagat gtaagcaaca agcacagcaa 9000 tcataaatga gtacggtgtc caattgacaa caaattctaa acattttaac agaaatcagt 9060 cgagagtaga gtttggtgtg taagcactaa agagaacaaa gagcgtcaat tatgatttaa 9120 aaaaaattac aattgcgtta gaagcagtga gcaatccatt attaatacac cacgtgtaag 9180 ttaaagtaaa ccatataccg gataaccctg tttgctaagc acgctaatct atccagatat 9240 tagacctgta ttattatata tgtacatgcg taaaagagtt tatattgtag agtgatatta 9300 caaaaaattg aatcatcaat ctttagcgtt attaccataa aaactttact tttggttcaa 9360 cattacgcaa atagttatac ggagcgggcg tatgaaacaa tccaaatttt atctttcaca 9420 ttagcataaa atatggcagt catgctgaaa aagattgtaa aataagacca tactacaatt 9480 tataaataaa aggcattgta aatgtcttat aataattgaa agtatattga taaaatgtgc 9540 gaccaaaaaa ttttttttaa atttttacga ttacaataaa tacttttctc agtggtacac 9600 catttgaaac ttgattgtta tattttggct aattacgttt aaaaatagtg cggttgtgtg 9660 gaaataatct ggaaaatcca ttttttggaa aaattgtttt gcaacagaat tctatataaa 9720 aaattttgaa ggttttagaa aacttgcaag aattatttag gacttgtttg ttaatttcgt 9780 tgaagactta cagcaatcat tactttactc tcaacatgtt cgaaatttat ataatcctga 9840 tgaagttata atagtagtta gtttcacaaa ggtttttttt ctgctaacta aatagagaaa 9900 ttatatatta tattacagta caatttaagg cttgctagat ttactcaatc gctcatacat 9960 acatatatgt atgcaaaaaa aagtcgaaaa cggcatatta tcagcaatca tatttgtctt 10020 tgttacgaat gcaatgttgt ttattgaatt caaaattgct aggcagccta ttacggctgg 10080 gcatggagtg accagttatg tgcgttatga ggaaagtatt caaaactcaa gagactctca 10140 agctacccct aataccgggg ctttgaaaat tttaacagca aaaacggagt agtataatac 10200 aatagtattc tttcacgact tcagtgaata ttaaggatcc tgcaagcttg actttgcgtc 10260 attgacgtta tggcaggaac ctagtaattc ttcagttacc gctactacaa ttgcttttat 10320 tccttttgtt aaatcctcca ctaaaaaatt acatttttat cagttatctt tttcagtcat 10380 cttggagaat tagtaaattt caagttttcg tctcgaggaa tacgttcggt tgtccgtctt 10440 ctaccaaacc gtttatgggg ttgaagatta ccctatgtac gaatttctca ttattatagc 10500 taaaaccaaa ggcttctttt tcaatattga aaggtacgaa tgcttagctt gcagatcaca 10560 aaaaacctgc ttcgagttta cttttgttaa ctcttgagag agagcttcgg aatattcctt 10620 ccacggtatt aatgaggaag ccattacaac caaggacatt gcatcgtaat ttgcaaacta 10680 ccagatgttt tctttgctac tgaatattat gaagaagtcg ttgaataatt tagaaatatc 10740 atttgtcgac aatcaaacca acctcaagtg acttgaagca gcactactga ggaggaaagc 10800 cttcgcataa ccaaatgttt attaatttag cgattttcgt cgtcaagaaa taatcatgtc 10860 aaaaggcgaa ttctcattgt taataatagg attctctcaa actcactgta ggtaaaatga 10920 gccaagaaag tgatccctgt tacctgtctc tatgcctaca ttcattgaac aagatgtgca 10980 ttctaatgct tagtgctcaa tttatatcct ccttgatatt ataagctttt tcgacaatat 11040 aagaaaagaa agaaataaga gattagttat gcgcattgca ttgaacaaag gatacgagaa 11100 gaaacaaaaa gcgtctttgg aaaaaggctc catagtggtt attttcgaca attcagaagt 11160 gtagggtttg atatgatatt aaattaaaca aggctccatt tgtttgacga acatcccagt 11220 tatctaggga caccacatat taaaatgatt atctattgaa ttaataatta tttactatta 11280 gggtattgaa tatactttat ctcgaaaaac taagttgcct tctacctctt ttactcttgt 11340 tttaccgaag tctagacttg agttcatcaa attcaagacg atattgtatt gcattatctc 11400 ccctaaagaa aggagtttaa gtgctatttg gtggtgatgg cgggtgtgag acttacccat 11460 tagttgcgat aggttttcat gtgtttgaaa tagataatta aatccaagca tgaataactt 11520 ttaaataaat catcattacc tttaaatgtg aattttacaa ataaatacaa attttataga 11580 ttcattgtcg ttatattgat gatctcaatt tctgcaatga aacttaacgg tcaattaaag 11640 ttgaaacagc acgacgaaca caggacggat tgttcacata attcggtaag atatattagc 11700 gctcgctatc cttcggagat atacttgata atctatgtct aaatttgcat tgaaaaaatt 11760 atatataatg agggataaat gttttgtttt ctatactctc ctgctttact agtcattcgc 11820 aattgtaaca gtagattttt tgcatcatta ttactctccg aaacatgact gaacactcat 11880 ttaagcaaat agacgtgttt tctaataaag gttttcgagg taatcctgtt gcagtttttt 11940 ttgatgcaga taatttatca caaaaggaaa tgcagcagat tgccaagtgg acaaatttat 12000 ctgagacaac atttgttcaa aagccgacaa tcgataaagc agattacaga cttcgtatat 12060 ttaccccaga atgtgaatta agctttgctg gtcacccaac aattggatcg tgctttgctg 12120 ttgttgaaag tggatattgt actccaaaaa actgtaaaat tattcaggaa tgtttagccg 12180 gtttagttga attaactatc gatggggaaa aggatgaaga cacttggatt tctttcaaac 12240 ttccgtatta caaaatttta cagacttctg aaactgcaat ttcagaagta gaaaatgcat 12300 tgggtattcc tctgaattat agttctcaag tttctcctcc tgtgttaata gatgatggac 12360 caaagtggct tgtaattcaa cttccaaacg ctacagatgt gctcaacctc gttccgaaat 12420 ttcagtccct ttcccaagtt tgtaaaaaca atgattggat aggcgtcacc gtctttggtg 12480 aattaggaaa agactcgttc gaaagccgaa gctttgcgcc tttaatacat gtcaatgagg 12540 atccggcttg cggtagtggt gcaggagctg tcggtgtgta tattggaagc tctcaaaaaa 12600 ctccaacttc tctatcattt acgatttctc aaggtacaaa attaagtaga caagcaattt 12660 ccaaagtcag cgtagacgtt tcctccaata aatcaattgc tgtttttgtc ggtggacagg 12720 caaaaacttg tatttctgga aaatcgttta tttaatgttt ttattacaaa tattcacttg 12780 cgagtttatt ttccaatact gaagactttc aatcaatagc aaatatgcta ctcaaggaag 12840 ttcactcatt caaaagcaat tggtttacta tatcgttttt tctaactagt tactagtcat 12900 tgaacaatct accgaatgat aaaatgaaat tttggttttt caatatgtga tgcacgtacg 12960 agatctaagt tcagaaaatg tagagaataa gaggaaggca gtattttacg tccttgattt 13020 atttcttgca ttcttactat atactcctta acacatttac aattatctaa acttcctgcg 13080 aaatgtaatt tattatgaac aatatttaat atttatattt gacaccaaga atagctgtcg 13140 aagcctgaat aatatatact attgcactac atcacattaa aaatttccag catcttaaat 13200 aatttgatat gaagattgac aaatctagat agaaagtaga atgttttata ctttaatcgc 13260 aatatttgtt tcatgcttta ctttattcga ttttaagttt cgtgtaaagg taaacaaagt 13320 attaagtaga aaaagttgtg gtgcttccca ttgcttagat ttcaattccg attgaacttg 13380 aaaaaaagtg gctcattagc aatcgtgatt tgaaaaaata taaataaata aatgaatgga 13440 acaaaaatat cccgggagat gcactaactg tgttaaactg aaaatgaaac atctgtggta 13500 tacattcgga tgttttcttt cgacagccga cttcctaaca taacctccga catctggtca 13560 ttttttattt acatgaggct cagaagtgga caattcgttg ttcgatttat atctgaatgt 13620 taatacgtaa cgattctggg gtatcaataa gagtctccac taaaacagat ataaaggggt 13680 aagcccaaac ttctcttgac atacatttga aaacacaact acgaagagta ctaatgtcga 13740 aggatataca gcatctcata aaaccttggc tactacctcc aaaaaaaact atgcctttac 13800 aaatgccaat atagtcgacg ttgtaacagg ggaaataata aaaagtgcta ctatttatac 13860 caacgatgga attataagtc aaattgatac caccaaagga gcagtgaaag agggtttcaa 13920 tgtcgtggat cttgagggac aattcgtatg tcctggattg attgacgcac acgttcacat 13980 tgtggctgtt ccaggagaag ctgatatgaa gtctgcctta cgactctcat tttcgcgtgc 14040 tgtcttacgc tttcacaagg tttgtaacca aatgctagaa agaggattca ctactgttag 14100 ggattgtggt ggagccgccg catttgttcg ggatgccata gaggatgatg tcattcacgg 14160 acctcgatta cttctagccg gaagagctct ttcacaaaca ggtggtcacg gtgatttacg 14220 tgatccggtt tccgaagacc atatggaagt ttcttgtggt tgtcaaagta atgtatctct 14280 agaatatgtg atggagctga tgaatgtttg aaggcagcaa gagatgaact gagaaaaggt 14340 gctgacttca tcaaaatcat ggctggaggt ggagttgctt ccccaactga caagttatcc 14400 tcacttcagt ttactccgga agaaattagg gctattgtaa aggctgccaa cagtagcggt 14460 tcttatgtta ctgctcatgc atatacaact cattctattc gtcaatgcgt ggaaaatggt 14520 gtacgaggga tcgagcatgg taatttaatt aacgaatcga cagcagcatg tatggctgat 14580 catgatgcgt acctcacacc cactctcatt acctacaaga taatggcaag cgagccattt 14640 tccaaattcc ttcctgaagc atcaagaacg aagaatgcag aagttcttgc ttcaggatta 14700 aagtttttag ctattgcaaa aaatgctggc gttaaatttt gctatggatc cgatttattc 14760 ggtcctttga ttgcagcata gaccggcgaa tttttattac gttccgccgt atgtaagcct 14820 atcgaaattt tacaacaggc tacaattaat cctgccaaac ttttcggaat ggagaacaag 14880 ctaggacagc tgaacccagg tttttatgct gaccttataa ttttaaacag taacccattg 14940 gaggacattt ctatattgga taagccggat cgtcatcttt tagctgtcat gaaggggggt 15000 agaattttca aaagtagatg gactaaattg cctagtgata tcgtcgtaaa tgatgttatt 15060 atgtgaatac tgattattta atcatttatc acttaccaat tggagatgac ttagactttt 15120 taacgtgtaa ttttaatgtg cacatataac cagatggttt tgaataagca tcgtaaaagt 15180 taggatattg gtgaacatag attatcgtaa acaagaaaat cgtctgcact ttatagttct 15240 catttgcttt ttttttttat gtagatcact ttaagacaaa actttttttt ctttctttaa 15300 gaaagaataa caaatatcta atgctttcac atgcatttga gttggatgca attgaatatt 15360 cgaaaaagga ttcgatgaac tttacaatta ttgctataca taacaattag acagaaagaa 15420 agtactagag tatatttaaa cttcatttca tttaccagct ttggttattt taataatgaa 15480 attaaatatt atatcttaat tcgaatattc aaaatatagg acaaaactaa tttctctttc 15540 ttgaaattaa aaataaatac gcttttgcat ccatttcaga ttagctaatt acctccaaac 15600 tttggaagta tcaataactc ataaagacaa tgtactagaa aaagctaaac ttttccgtaa 15660 ggggtgtttt gtataaaaaa ttatataaca gcatttacaa gctttccaaa attataaaaa 15720 catatgacaa ttggtgagaa taggttgaat tctgtgttat aaattcgaaa aatggattgg 15780 catcgacaaa tgaaacattt aaaagtttga aatccacaga aaatattaca ggcaaattct 15840 cttttagatg atacgcttga ctaaaggtac aatcctgtca gtagttttcc atcccatttg 15900 atacattact aggtagttaa tatacttgaa gctaaataat cagggaattt atttaaaact 15960 tttttataaa gctaaaatat gtaattagac aagtttattt ttcctataaa gtcaagtttt 16020 acaatgtctg ttaaacgctc atgggaaagc tgtttagtag taacttttaa ctctttccgt 16080 taagaataat tccatacgtg atttactgta tttcatcata atttacagtt acgattcttg 16140 taatagtata ccatcacttt gaggaatggt tctatgatga taacaaacca gctacgttta 16200 gaaacagtcg caaggtttgc attttcattt cttcttttca ggctattcgt aacagacctt 16260 gtgtatttat ttcaaaagtt tttttgcatt ttattatttt ccttttaatt ctatataaac 16320 gataacaaat tttaaaagca aatacactga tccttttttt tttattttat aaaaataaaa 16380 atacgaaaaa aatggatctg taaattgatt ttttgtaaag cctttcaaat ttaatggata 16440 taaatttttt tatatcaagt atttaaacca aagatatctc aataaatcat cgcataatct 16500 tttaaacata agcggacatg aaatcataac cataaacttc atactagtga attatttata 16560 aatttcatag ggacttatag acagtttaaa aagatgccca attcttataa catcgatata 16620 cttaaatcga tttgaacaag catcaggtag caactaatgg tgagagtgtg catagccgta 16680 taaccgatac aagtgacagc aatattagca gtgaaagact gctaaaatat cgatcataat 16740 tgaaccgtac tcgatttgtc cttttgagat ttagttttaa tacaggatta ctaatacatg 16800 tagagaggaa taaatatagt ggcgaaattt tctgtatatc tgaatattcg ctatcattta 16860 caagaagtac gtgaattttc ttagtaattt ccctctgcga actaatgaca gctttcatat 16920 ctaacatata attttgcaaa ttgaagtaca aaaccaaagt tttcctattt tgactgttta 16980 cttctatcaa gatttgatgt catataattt aaacattcaa caagatgaaa ttgatttttg 17040 aagcaattga aacgaaatta gttgaactag agtaactttg tctacactag cattagcaag 17100 ctttctcgac gctacatgta cctatgttat atttaagttg gaaatactga tatagacata 17160 cttagaacac tccccttttg aatacaagaa actacctcaa tccacgaatc ttaaatgaaa 17220 tatttagttc cacacacgtt tcactacaag tgctgttgat gatcagctga taaggctaca 17280 gaaccggccg atcaattcaa ctgctttcct agttgaaaac cagaattaat acagaagtaa 17340 aacatgaata cacctaaacg gaaaacatcc gatttagtta tatggctatc tacaaataat 17400 tttccatctt atggtggaaa taaaactgtc ggtgattccg gttccgtgta accgcaacct 17460 ttattgcgta cttctgctta cgatgttggc cgcacaccta tgcatacata tcagatagag 17520 gatgtaagtc aaacatttat tatcgtaaat cgggaaatca tccgaggatt tgctagaatt 17580 tgaagggagt gtgtgtcgat gagccatttg ttcgtcatac agcagagaat aacgaggtgt 17640 tgaaagaaat aagtcaggta atctccacaa tgctactaag caatttccgc tgaactacaa 17700 tttcgtcagt tcatacaact taaaatgctt tgttgaacaa ttatggagta gtaccctcat 17760 tcaaataaaa tgccttccgg tttttgagtc cccacctttt cgttcgtcga gtttccattg 17820 caactacatg accaaaatgg aaacaaaaag acatcgtatc cgctttcaag ctaagggaat 17880 caaagataag ataatgaatc caccgtcgat ttttttcttc tatatataaa gatcaattta 17940 tgcaagtgat tttctcattg tactgagttt tatacaaaat gtggagctct atcatcagtt 18000 tcctattctt ttctgtggca ttatgtcagc cattgttgtt tcagaagcgc tcttctaatg 18060 tttcggactt catttcattt aatgcttcac ttcccaatgt tacaattttt gcaatgggag 18120 gaactatcgc tggatatgct tcatccagca ctgaaacagt tgactatgcc gctggctctg 18180 taggaatagc aacactggtt gatgcagttc ctgctatcaa gaacttttca aacattcgtg 18240 gagtccaagt tactaatgtt ggcagtgaag aactgacacc tgctaacgtt ttgaatctta 18300 ctcagttgat tctagccgaa gttgccaaac ccgatgttca tggtattgtt gttacacatg 18360 gtacagattc acttgaagaa actgcgatat ttttggacat gactgtcaat actacaaagc 18420 ccattgtagt tgttggagca atgagacctt ctactgcaat tagcgctgat ggccctatga 18480 acttgttaaa tgctgtagtg gtagcggcct ctaatcgatc tattggtcgc ggtactatga 18540 tcttattaaa tgatcgtatt ggatctgcct tttatactac aaagacaaat ggaaatatgc 18600 ttgatacctt caagtcatat gaggcaggat tccttggtat gattcttgat caaagaccac 18660 atttcttcta tagccctgct acaccaactg gtaaagttca ttttgacgtt agcaacacta 18720 ctgaattacc agcagttgaa attttgtatg gatatcaggg actgaatcct aacttggcaa 18780 aggctgcagt agatctggga gccaaaggtt tagtcttagc tggcatgggt gcagcttcct 18840 ggacggatcc tggtaatgaa gtgattgatg gattgattag taaccaaagt attccggttg 18900 tgtacagcca cagaacaatg gatggatttt ctgactatta ttacaacgga attcctgctt 18960 atttccaaaa tccgcaaaaa gctagatata tgcttatgct ttccattaac gctggctatt 19020 ccattcaaaa cataactgat atattcagtc ttgagtatta gtgttatttc ttggagttat 19080 ttatcaacca ttcgatattt ctgttttgaa catagaatca cgagtatcct tcgtttacga 19140 agtagaactt gttaaaatta aatctggata atgcctagtc aaaccaattg ttttattaat 19200 tagaaaggaa aattaaaacc tctttttaaa taaatattac tttattataa cttttattta 19260 agactgtata aaaatttaac aaaaacatat gttaatcaaa atcgaatttt gggcgttaga 19320 caaattccac atgtatttga ataatagcat tgtattaagg aaaggataaa actgaaaact 19380 atccatttta caaatgatca tctatactta cttaccttcc tgttacattc taacttaaaa 19440 tatttggtat gaagatgcgt aattttcaac taatacaagg agatacagag atcttacaca 19500 caagtgggta agacatcgta agcgaaatag cctggcataa tatttggcaa agagtctcaa 19560 attttaatga tttgtcgtac acaccaattt attttagcca ataaaaacat ggaatctgca 19620 agttaagcaa tacgaagtgt gtaacaatta ttgtaaagtg caaaaatacc tagggccaaa 19680 aaggcagttt agtcacagtt tgactaattg gaaatctttc agttgatgag attttaatag 19740 gcctataact aaatgctggt ccaactaata gaaaacatta cgtaagcaaa ttgataaatt 19800 tttggtatat gaattgatat agcaaaacaa tgttatctat cggttctgct gacggcgcta 19860 taccaaaaca tgaaatgtca tcgcctacaa ttggaaataa tactagaagc atcaataaat 19920 ggattcgaag accacaaaag caaaaaaata aaaataaaaa aaaataaaaa atgccaaata 19980 aagcaaatta catgactgag acatttaatc tccacagtaa tacgtggatg atagcagtaa 20040 gtaatagtat tagaaagcaa aagaaaacga ctcatcattt caccagtgca tctaacatag 20100 atggtattaa ggatcaaatt tattcagaac aattcctgaa tattttgtat actcgtttaa 20160 atgaaatgca cagcgtagga aaaaaaacca tatcttgccg attgtgtaaa tcccaaaaac 20220 ttgaggattg aaatcgttgc tgtgtttgag caattgtaaa ccatattggt ataataacat 20280 gatattgtta aaagaaaagt tgaagtatgc agctagcagc agaattttga aaagctagat 20340 agtacagtag atggtttcaa ttcttgctat gttaataaat tacacataaa attcacgggt 20400 ataatattaa tctacaaaga gcgtaaactt ttgttacagt tgtaatcatt aaggtgatat 20460 gctcatcatg gtttaggaat ttaaagaatt cttccttcga gtttgtaaat acatacaaat 20520 gcttttatat gagaattcac ttttttttta acatctaaaa cagtggtatt tagatattct 20580 acattagtaa gcgaaagtca attatatctc atctagatcc tttgctgaaa tacactgcgg 20640 taatttaagt aatgattgcc ggttatttgg attatttcat atacatggtt actcaattac 20700 atttgggtac aatttttctt ttctaaaagt tagctagcaa attcactcaa aagatcgtag 20760 attttccgta tcttaggttg tttctgcgaa acctaggaaa tgcggcaatg agtaagaaat 20820 ttaaatttgt taacaagtaa attttgtcac ataaaagaca gcgccaatca gagtttggga 20880 tccgacccct caatatgagt caaataaaat ggcatggaat aagctctaca gcagtaatcg 20940 aagggtaagt ggtttgattg tccacaattt cgcagttcat agagattagt tttcaaatct 21000 actcctgaat aataatagct gtgaacttat tatagaagtt cgaaaggtgg ttaatattcc 21060 gacttgagaa cggtgactac attctttcga gttttcacaa ttaagagtct aacacattct 21120 tttaggacga acagtgatat ccaggaaacc atatagtcct ttctaaaata cagcatagta 21180 cacacacctt ttgtttacga ccatcggcat ggaaaaatgc cttttgaaga agtgtattgg 21240 aggggagctg ggtagaaaat ttgccttgtt ggaccgatta attgaaagaa atttgaatac 21300 ctctggaccg aataggtgat agttatttac tattgacaac ttataagata tccgtattgt 21360 tacttgattt gtaatttagc gttcaaactc tgacaaggaa aatggtcaat gtaggaattg 21420 tactttcaca aaccgtgctt ttcattagta ataatttagg attgataaat aagtacgttt 21480 tcttagtata cgtacgacat cttaggtttt ttttattttg ttattacaat tacagtgctt 21540 gctaaacaaa ctcaactaga tggtcagaaa gtttttcggg aagatatcgt aagtatatca 21600 agtttgttga gacacgtgta aacggcaaac aaaatctcga aaagggagta aataactaaa 21660 taaagatcgt aacaagataa tttgaacaaa aaaaaacaaa tttagtgata ataaaaaggg 21720 atatttgttc agcagaacgc accataaatt ttctttaaaa catgtttaaa tccactagat 21780 gtctcatctt cttcgtcaga attttcataa gttcgtaggc cagttgaaat atccagttta 21840 tccaaagacg ggacgtgtga tc 21862 //