ID SPBC902 standard; DNA; FUN; 14450 BP. XX AC AL133306; XX SV AL133306.1 XX DT 01-DEC-1999 (Rel. 61, Created) DT 01-DEC-1999 (Rel. 61, Last updated, Version 1) XX DE S.pombe chromosome II cosmid c902. XX KW chl12-loke protein; Isocitrate and isopropylmalate dehydrogenases; KW isocitrate dehydrogenase [nad] subunit 2, mitochondrial precursor; KW putative gamma-tubulin interacting protein; KW putative spindle pole body component; RNA recognition motif; KW RRM, RBD, or RNP; yeast SCP98 homolog. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-14450 RA Saunders D., Harris D., McDougall R.C., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (30-NOV-1999) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; Q9USP8; Q9USP8. DR GOA; Q9USP9; Q9USP9. DR GOA; Q9USQ1; Q9USQ1. DR GOA; Q9USQ2; Q9USQ2. DR SPTREMBL; Q9USP7; Q9USP7. DR SPTREMBL; Q9USP9; Q9USP9. DR SPTREMBL; Q9USQ0; Q9USQ0. DR SPTREMBL; Q9USQ1; Q9USQ1. DR SWISS-PROT; Q9USP8; IDH2_SCHPO. DR SWISS-PROT; Q9USQ2; ALP6_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c902 is overlapped at the 5' end by cosmid c428, EMBL entry CC SPBC428, accession number AL034382, and at the 3' end by cosmid c1685, CC EMBL entry SPBC1685, accession number AL031154. XX FH Key Location/Qualifiers FH FT source 1..14450 FT /chromosome="II" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c902" FT /map="IIL" FT misc_feature 1..102 FT /note="nominal overlap with cosmid SPBC428 S. pombe FT chromosome 2" FT CDS join(complement(1652..1779),complement(1551..1612), FT complement(1..1510)) FT /db_xref="GOA:Q9USQ2" FT /db_xref="SWISS-PROT:Q9USQ2" FT /label=SPBC902.01c FT /note="SPBC902.01c, len:526, SIMILARITY:Homo sapiens, FT O60853, protein encoded by saccharomyces cerevisiae spc98 FT homologue., (824 aa), fasta scores: opt: 633, E():1.8e-31, FT (31.6% identity in 411 aa)" FT /partial FT /gene="SPBC902.01c" FT /gene="SPBC428.20c" FT /product="putative spindle pole body component, putative FT gamma-tubulin interacting protein, yeast SCP98 homolog" FT /protein_id="CAB62095.1" FT /translation="MSEIHVKTALSRLADKYLQNSKNPSVPYTIETIVSFFQEIIHSIS FT PDTFQLDIDDILYKIYSKIPPEENNDALFSKLSNLVSRLKSQTVIHNKSQILYFLYLLS FT PISQSSRDVSSHLLDESISNPINIPSTEVESSNFGQTRYDQVPENPQITDWDEGLENES FT SISIAHDSSRLNRSTETSSVQHTLITEADLLSSISYVLQGISTEYVQFKNELALLSKRI FT PVQYLLQMRALSETGLLYQELKVFSNYDPSVSQSIDGDNVSKAFINDQSLALQSLKSVI FT SKELTNFLALIASLDSQIRADASLEKPMVTIRRCIAWTQVAKLKLRILSSVVNDNMNQE FT NKKRLIQVVSKYNVHGDPLIQELSDKILTEITGPLYEMIENWIYKGELVDPYQEFFVKE FT KNGSESHDHQGQGDVVWKGKYFLDKELIPSFLSEELVDKIFLIGKSLNFARYGCGDFDW FT AQEHYQKLVKKLSYRDPHSLETVVDKAYTESINHLVYLMEEVFHLTDHLKAIKKYLLLG FT QGDFVDLLMESLGNSLDQPANTLFRHNLTASLESAIRSSNASYEPEYVL" FT CDS join(complement(2646..5033),complement(2435..2565), FT complement(2022..2385)) FT /db_xref="GOA:Q9USQ1" FT /db_xref="SPTREMBL:Q9USQ1" FT /label=SPBC902.02c FT /note="SPBC902.02c, len:960, SIMILARITY:Saccharomyces FT cerevisiae, CH12_YEAST, chl12 protein., (741 aa), fasta FT scores: opt: 894, E():0, (28.7% identity in 705 aa)" FT /gene="SPBC902.02c" FT /product="similar to S. cerevisiae chl12 protein" FT /protein_id="CAB62096.1" FT /translation="MDSIPNEDDLEKLLVAEQNVPYGKNYESFEDEENYLLELRNANAL FT ENLEHRSIPNDLFHSSQPVGSPTRNGDDIPSTLDLYSSDNAAIDTDISEDETINQRHAP FT QTDYRYPNTSANPKMGLEESMDIDMPSIDLDISNAAAFPRDSNLLFRNYNSHTKTSEKG FT SPVNFEKENQDSNVLFSTGRTSVLHIDAEQSQTNNTVTPLKDDALSLFSFENDVNGAVN FT DNSLDQKLSASKNSQRVSLPFFSKIELDEGSSFSGPKISARTSSGKIIYFPKKKNRHSD FT GLLLQPKRLADEISQVNEIGKDFNQDLLNSVRIWSENFLIVSKEKSVALKTEKLDSLQI FT TNCTTKPQSQKLWVDTYRPQLFRDLLGDERVHRAAMHWIKAWDPCVFGKSRLQPSKSMR FT FNPRFTNITSDSDRPDKRIMMLTGLAGAGKTTLAHVIAHQAGYKVLEINASDDRTAHTV FT HEKVSSAISNHSALSSQPTCVIVDEIDGGDPAFVRALLSLLESDEKATEYSQAGNSKKK FT KKFKKLCRPIICICNDLYTPALRPLRPYAQIIYFRPPPQASLVGRLRTICRNENIAVDS FT RSLTLLTDIYNSDIRSCINSLQLLSLNNKRIDSETIKLLQPKSNSFSTSSLIQSLFLQL FT DNKQIRAIEASQPTYSHLDALLARIDGANDSESVLMNCFHTYLDLPFTDSLLSKPALTS FT EWLYFFDQLHSQCYKGNYELWRYIPYSIIHFHYLYATPEKCRLPHPPRSDLEALKLYRT FT RKEILDSFISTLNAYENQMHGERSILLELIRTILITINPTLKQKEDSMPRSALPSKIEH FT AINILNHYNLRFQQLPVGDGNYVYRLEPPLDELVWDAPTSSYSVRQMLSQELLKKRLAD FT IKKQTLTDNPTSSNSSRKRKDFNSGKAIKRDFFGRIISEPKSEAVTSNNAALNTGDHPV FT SIKHAINIKFHDGFSNAVRKPISLNEILNF" FT misc_feature complement(2386..2398) FT /note="ctaacgttgacag, splice branch and acceptor" FT misc_feature complement(2429..2434) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(2566..2579) FT /note="ctaactttttatag, splice branch and acceptor" FT misc_feature complement(2640..2645) FT /note="gtaagg, splice donor sequence" FT CDS 6303..6845 FT /db_xref="SPTREMBL:Q9USQ0" FT /label=SPBC902.03 FT /note="SPBC902.03, len:180" FT /gene="SPBC902.03" FT /product="very hypothetical protein" FT /protein_id="CAB62097.1" FT /translation="MSSYVPNTLSVYHNLLILEASFRKTYLQLQVRRQKYMAFYVSLLV FT WNFYFGYRVFYRISKYSLIDLTYKLCLLCGIVTLLLFYFSGLYRTTIVYPSRYVQQVNK FT AMRFFNIRLVITPVPWFQVRKPLDCGVHLILSSKRFDILVIEGWEAFRSSYFASIHRKN FT NSIQSNESSESPSSKQN" FT CDS join(7955..7984,8023..8060,8151..9693,9748..9906) FT /db_xref="GOA:Q9USP9" FT /db_xref="SPTREMBL:Q9USP9" FT /label=SPBC902.04 FT /note="SPBC902.04, len:589 SIMILARITY: C. elegans, Q10954, FT hypothetical protein, (717 aa), fasta scores, opt: 311, , FT E(): 5.7e-09, (23.7% identity in 490 aa overlap)" FT /gene="SPBC902.04" FT /product="hypothetical coiled-coil protein; with RNA FT recognition motif" FT /protein_id="CAB62098.1" FT /translation="MPLFLEEHAEYLKRYLEQALEPISDADASVLSDYAMALLRHDSSE FT EEVRQLCYSQLEDFLRQETIPFVDKIFDVLREKSYLEGASNMPSTGMVTEEVSRYSPTS FT SMIPATNSMETNFNNSLPAVGKTNTFPSQVPNMFGPPLYHPAATAPSEFMPSIPGFGNL FT PNPAMPPIPFLPFNPAAQPPFPPPFKMRGKRGFGMRHEHNSELRRHSPGNRRFNPYKAY FT PQPHLGHRFSRNAGNDPTSTALEVRNIPEEHFNEENIRSFFSKFGVLEKVELNPTHHSC FT VLEFTSHEAANNAWSSPEPIFNNRFIKIFWYNPSKGFHNRPKKFASHKSPTTSDSSNVE FT SSEDVDPASLLQNEEFHKLIEERQRQHEERLKRINANKKALEELNQKKRELAQQQLKEQ FT ELLMQKIKETDRSGNKRLMLLETQHSLLKAEADCLGLPVSNVSESPAASNGSHHPYASG FT LPQRGTNTFFRGRGRGRGDMFASMSIDNRPTKLRVINVSPEKNEALLQYLFTVGGYEEI FT TEPSTTERLISFQNRNSAEKFFGGVRNVEKLQELELAWVPKTAVTTNTTSMETGESNTS FT DNMNIEVEEGRWR" FT misc_feature 7985..7990 FT /note="gtaatt, splice donor sequence" FT misc_feature 8010..8022 FT /note="ttaacgcttttag, splice branch and acceptor" FT misc_feature 8061..8066 FT /note="gtatgt, splice donor sequence" FT misc_feature 8135..8150 FT /note="ctaacgaaatgactag, splice branch and acceptor" FT misc_feature 8684..8881 FT /note="Pfam match to entry PF00076 rrm, RNA recognition FT motif. (a.k.a. RRM, RBD, or RNP domain)," FT misc_feature 9694..9699 FT /note="gtatgt, splice donor sequence" FT misc_feature 9734..9747 FT /note="ttaacaaattttag, splice branch and acceptor" FT CDS join(complement(11657..11728),complement(11407..11550), FT complement(11311..11359),complement(10392..11156), FT complement(10235..10341)) FT /db_xref="GOA:Q9USP8" FT /db_xref="SWISS-PROT:Q9USP8" FT /label=SPBC902.05c FT /note="SPBC902.05c, len:378, SIMILARITY:Saccharomyces FT cerevisiae, IDH2_YEAST, isocitrate dehydrogenase [nad] FT subunit 2, mitochondrial precursor(ec 1.1.1.41), (369 aa), FT fasta scores: opt: 1468, E():0, (62.5% identity in 365 aa)" FT /gene="SPBC902.05c" FT /product="probable isocitrate dehydrogenase [nad] subunit FT 2, mitochondrial precursor(ec 1.1.1.41)" FT /protein_id="CAB62099.1" FT /translation="MSMLSTLRTAGSLRTFSRSACYSFRFSSTKAAAGTYEGVKNANGN FT YTVTMIAGDGIGPEIAQSVERIFKAAKVPIEWERVKVYPILKNGTTTIPDDAKESVRKN FT KVALKGPLATPIGKGHVSMNLTLRRTFGLFANVRPCVSITGYKTPYDNVNTVLIRENTE FT GEYSGIEHEVIPGVVQSIKLITRAASERVIRYAFQYARQTGKNNITVVHKATIMRMADG FT LFLECAKELAPEYPDIELREEILDNACLKIVTDPVPYNNTVMVMPNLYGDIVSDMCAGL FT IGGLGLTPSGNIGNQASIFEAVHGTAPDIAGKGLANPTALLLSSVMMLKHMNLNDYAKR FT IESAIFDTLANNPDARTKDLGGKSNNVQYTDAIISKLK" FT misc_feature join(complement(10392..11151),complement(10253..10341)) FT /note="Match to PF00180 isodh, Isocitrate and FT isopropylmalate dehydrogenases Score 399.25" FT misc_feature complement(10342..10355) FT /note="ctaattaccattag, splice branch and acceptor" FT misc_feature complement(10386..10391) FT /note="gtatgt, splice donor sequence" FT misc_feature complement(11157..11169) FT /note="ctaattcgtttag, splice branch and acceptor" FT misc_feature complement(11305..11310) FT /note="gtatgt, splice donor sequence" FT misc_feature complement(11360..11378) FT /note="ttaacgacttgtattgtag, splice branch and acceptor" FT misc_feature complement(11401..11406) FT /note="gtttgt, splice donor sequence" FT misc_feature complement(11407..11484) FT /note="Match to PF00180 isodh, Isocitrate and FT isopropylmalate dehydrogenases Score 26.11" FT misc_feature complement(11551..11572) FT /note="ttaacagagttatttttagcag, splice branch and acceptor" FT misc_feature complement(11651..11656) FT /note="gtaagt, splice donor sequence" FT CDS 12815..14008 FT /db_xref="SPTREMBL:Q9USP7" FT /label=SPBC902.06 FT /note="SPBC902.06, len:397" FT /gene="SPBC902.06" FT /product="hypothetical protein with coiled-coil region" FT /protein_id="CAB62100.1" FT /translation="MSEHNYQSDREVAEDPFLNYEASANQLSSNSRESTPRGSPWRAGM FT RSASLMTEPLEDSMYSDNNYLDNGVSFTKDENPLYSPSWPSLADANVNSMKSNNAIQEH FT KAAKFVSEKSLEKVSTADNNLVLQELENLRERLNQVELQLSERPSSYLGYHNNLSPYRS FT PNSYPSLLPSTHSPHSPAPLSTMQTALMRLRTYHPSPIILKPVEQAVNHAITLVNTSPS FT SVVDALCRSLAELCLGLVQEAIDASILSQQESSNSLDLVRHTPPLNYTSSVDSSPQRMA FT SDSYGRPSLHLNDPFPSVDLQSNELSHHNVRTTLFSDDSRFHSKIHTHSTPPSQMYSAA FT SHFRYRSDPSTRHVSNSTNKSSLHPSPTSLRVAHPIIPQRASPASQSFPSLQDTPSP" FT misc_feature 14350..14450 FT /note="nominal overlap with cosmid SPBC1685 S. pombe FT chromosome 2" XX SQ Sequence 14450 BP; 4440 A; 2666 C; 2573 G; 4771 T; 0 other; tttaatacgt attcaggttc ataagatgca ttacttgaac gaatggcgct ttctaaagaa 60 gcagtcaaat tgtgtctgaa caaagtatta gccggctgat ccaaagaatt accaaggctc 120 tccattaata agtccacaaa atcaccttgt cctagtaaaa ggtatttttt gatagccttt 180 aaatgatcag tcaaatgaaa cacctcttcc atcaagtata ctaagtgatt aatggactca 240 gtatacgcct tatcaaccac tgtttctaat gaatgagggt ctctataact aagttttttc 300 actagcttct ggtaatgctc ttgtgcccag tcaaaatcac cacatccata acgtgcgaag 360 tttaaactct ttccaatcaa aaagattttg tcgacaagtt cttcagaaag gaaacttggt 420 attaactctt tgtctaaaaa atatttacct ttccagacga catcaccttg cccttgatga 480 tcatggcttt cactaccatt tttttcttta acaaaaaatt cttgataagg gtcgaccaat 540 tctcctttat aaatccagtt ttcaatcatt tcgtataaag gtccagtaat ttctgttagt 600 attttatcac tcaattcttg tattagcgga tctccatgca cattgtattt cgaaaccact 660 tgaatcaatc tttttttatt ctcctggttc atattatcat taacaactga agacaaaatt 720 ctaagtttta gcttggcaac ttgcgtccag gcaatgcaac gccggatagt taccataggc 780 ttctcaagtg aagcgtctgc tcgaatttgt gaatccagag atgcaattaa cgcaaggaaa 840 ttagtcagct ctttagaaat gaccgatttt aaactttgta aagctaaaga ctgatcgttt 900 ataaatgctt tactaacgtt atcaccatca atggattgac tgaccgaagg atcataattg 960 ctgaaaacct ttagttcctg atataataag cctgtctctg aaagagctcg catctgtaaa 1020 aggtattgga caggtattct cttagacaac agcgctaatt catttttaaa ctgaacatat 1080 tcggtagaaa ttccttgaag tacgtaagat attgaagaca acaaatcggc ttctgtaatc 1140 aaagtatgtt gaacagaaga agtttcagta ctacggttta gcctagatga atcatgagca 1200 attgagatag aactttcatt ttccaatcct tcatcccaat cagtaatttg ggggttttca 1260 ggaacttgat cgtaacgtgt ctgaccaaag tttgaggatt ccacttctgt tgatggaata 1320 ttgataggat tggaaataga ctcatctaat aaatgagagg agacatctct tgatgactga 1380 gaaataggag agagcaagta taagaaatag agtatttgag atttgttgtg aatgaccgtt 1440 tgacttttca aacgcgaaac taagttagat aatttagaaa ataaagcatc attgttttct 1500 tcggggggaa ctaaaaaact gttaattttg gtatttagac cttcacatac tttttgaata 1560 tattttgtac agaatgtcat caatgtccag ttgaaaagta tcaggagaaa tgctaacagt 1620 tagcatgatc atttacacga aattagctta cgagtgaatt atttcctgaa agaaagacac 1680 gatcgtttca attgtgtaag ggacagaagg gtttttggag ttctgtaaat acttgtccgc 1740 cagacgtgat aatgcagttt tcacatgaat ctccgacatt tgagaacttc aaatgacgaa 1800 agtatttttt ttatttttga attaaaatag agaaatacaa gtattgatcg ttaactcaaa 1860 atcttaaagc cattgacaaa gtacacgccg aagtcgcggt caggaaataa tggttagatg 1920 aatttacgca tacacctatt tttactagtg attttttttt aaattaaatg attgatttta 1980 tttcaaaaag attgaaatta aaaatattaa tgcacattag attagaaatt cagaatctcg 2040 ttcaacgata ttggttttct cacagcattg gaaaacccat cgtgaaattt gatattgatt 2100 gcatgcttga tggaaactgg atgatctcct gtattcaaag ctgcattatt cgatgtaact 2160 gcttcagatt ttggttcaga aatgatacgg ccaaaaaaat ctctcttaat tgcttttccg 2220 gaattaaaat ctttgcgctt tcttgaagaa ttcgaagaag tggggttgtc cgttagggtt 2280 tgttttttaa tgtctgcgag ccttttcttg agcagttcct gagatagcat ttgacgaaca 2340 gaatatgaac ttgtaggtgc gtcccaaacc aattcatcca aaggtctgtc aacgttagct 2400 attactagaa agaaataaaa atattggaac ttacggctca agcctataca catagttgcc 2460 atctccaacg ggaagctgtt ggaaacgcaa attataatga tttaaaatgt taatcgcatg 2520 ctcaatttta gaaggtaaag cgctccttgg catagaatct tctttctata aaaagttagt 2580 aaattaaaaa aatattgttt cacgcaattt tttttttttt tttttttaaa atatatagac 2640 cttacctgtt ttagtgtagg atttatggta attaaaattg tacggataag ttccaaaaga 2700 attgatcttt ctccatgcat ttgattttca taagcattta gcgtcgatat gaatgaatcc 2760 aatatttctt tgcgagtacg ataaagtttt aaagcttcca aatcacttct gggaggatgc 2820 ggaaggcggc acttttcagg agttgcatac aaataatgaa aatgaataat ggaataaggt 2880 atgtacctcc ataactcata atttccctta taacattgtg aatgaagttg gtcgaaaaag 2940 taaagccact cgcttgtcaa agcaggttta gaaagtaagc tatcagtaaa aggaagatct 3000 aagtatgtat gaaaacaatt catcaagact gattcagaat cattagctcc atcaatcctt 3060 gcaaggaggg cgtccaaatg tgagtaagta ggttgcgatg cttcaattgc acgtatttgt 3120 ttattatcaa gttgtaaaaa aagagattgg attaaactag aagtactaaa agaattactt 3180 tttggttgca aaagctttat ggtctcagaa tctatacgtt tgttatttaa agacaaaagt 3240 tgtaaactgt tgatacagct tcgaatgtca gaattataga tatctgtcag caaagtcaaa 3300 gagcggctgt caacagctat attttcattt cggcaaatag tccttaaacg accgacaaga 3360 gatgcttgag gaggtggtcg aaaatatatt atttgagcat atggtcgcag aggtcgaagt 3420 gctggagtat ataagtcatt acaaatgcaa ataatgggac gacaaagttt cttaaacttt 3480 ttctttttct ttgaattacc agcttgagaa tactcagtcg ctttttcgtc actctctaat 3540 aaactcaaaa gtgctcgtac gaatgcagga tcacctccgt caatttcatc aactataaca 3600 catgtaggtt gagatgacaa ggctgaatga ttgctaatgg cagaggatac cttttcatga 3660 accgtatgag cagtacgatc atcactagca tttatttcca aaactttgta tccagcctga 3720 tgagcaataa catgagccaa agtcgtttta cctgcacctg ccagtccagt cagcatcata 3780 atccgtttat caggtctatc actatcagaa gtgatattag taaatctggg gttaaaacgc 3840 atactctttg agggctgtaa tcgagatttt ccaaacacac aaggatccca agcttttatc 3900 caatgcatag cagctctatg gacgcgttca tctcctagta agtcccgaaa aagttgagga 3960 cgatatgtat caacccaaag cttctgtgat tggggttttg tagtacaatt cgttatctgc 4020 aaagaatcaa gtttttcggt ctttaaagcg acagacttct ctttagatac gatcaaaaaa 4080 ttttctgacc atatacgaac agaattcaaa agatcctgat taaaatcctt tccaatttca 4140 ttgacttggg aaatttcgtc agctaacctt tttggttgca gtaaaagacc gtcagaatgt 4200 cgattcttct ttttcggaaa gtatataatt ttaccagaag aagtgcgagc agatatttta 4260 ggaccagaaa acgacgaacc ttcatcaagc tcaatctttg aaaaaaaagg caaagaaaca 4320 cgttgggaat ttttagaagc ggataatttt tggtctaggg aattatcatt aactgcacca 4380 tttacatcgt tttcaaaaga aaataaggat aatgcatcat ctttcaatgg agttactgta 4440 ttgtttgttt gcgattgttc agcatctata tgtaataccg aggttcgccc tgtggaaaat 4500 aatacattgg aatcttgatt ttctttttca aaattaactg gagaaccctt ttcagaagtt 4560 tttgtatgcg aattgtaatt cctgaaaagt agattggaat ctcgtggaaa agctgcagca 4620 ttagaaatat ccaaatcaat agagggcata tcaatatcca tagactcttc aagccccatc 4680 tttggattag cagacgtatt gggataacgg taatcagttt gcggcgcgtg cctctgattt 4740 attgtctcgt cctcacttat gtcagtatca attgctgcat tgtcagaact atataaatcc 4800 agtgtagaag ggatatcatc accgttcctt gtaggagaac ctacaggctg tgaactatga 4860 aataaatcat ttggtattga tcgatgttca aggttttcta aagcattcgc gtttcgcaat 4920 tctagtaaat aattttcctc atcttcaaaa ctctcataat tctttccata aggaacgttt 4980 tgctccgcta ccaaaagctt ctccaaatca tcctcatttg gaatcgaatc catatgagtt 5040 ggaaatccaa attttcaaat ggaacatgta acaattatga atactgaaag acatcgtaca 5100 tccgaatttt ttataagcaa ttaccccgtg tgcgttgcaa tgcattatat gcttggagag 5160 taaacaaagc tttcactttg gttttttatg tggtaatttc aagtaatttt aagaaaagaa 5220 aactgttgaa gaatatttat ttaatgctta ttttattttt ctgtctgtta atgtctgata 5280 tgaattttaa tgaaactcat accgtgtgcg gagccaaaaa tttgcagtcc tattgacttc 5340 tttgattgtt cccaattaat ttggatttat ggttaatgtg taaaaaatcg ttgatggaat 5400 tacggcggtt ccgatcgtga ataggataat cgacttaccc caacactcta gagtgcgaca 5460 ttcctggctc ggctttttgg agtagaagat acaaacgaaa atagaaaatt gatctatatg 5520 tcgttcctaa aacttatgct tcaattctgc aaacactact aagttttttc agcttgcaac 5580 acgttaagct gcgtaactta tttctgctac tattttactc ggtataggat tgctgattga 5640 gttctttatt tctttattta tatatgatct tttcgccaac gtgtttaaac taggggagtt 5700 taattgctaa atcggctaaa aaactacaat gtaaaaactt ggcctatata tttttatcca 5760 aacataagat tttttaaata cagaattgat atctgagcag tcatttagta aaaagatgtc 5820 agtaaaagct ttctaatcca ttggtcggaa ctttttaaga ctttgatgtt taccaaataa 5880 tgaacacagt taacactccc tcactatatt ttgcatcgtt atacagtata ccaacgttta 5940 ctatcgttta ctatagcaca tatcgaagta gacagctgca cactattgat attatagcta 6000 tcggcgcgta gctttgacat tgacttttag aatctgccat ccgattgata cttgaatcag 6060 caaattagaa gggctgttct tttattgttt tagaatcatc ggcttgtact attactaatt 6120 gaattagttc ttatgttacg cacatatctc attctgtggt cttcataacg acttcttgta 6180 attggtgttg gatattgtcc aattattgtt atctccaaaa agctttctta tattctgttt 6240 ttcaagttct ttatatcttt ttattctttt tcctacgtat tgttaagagt gaataaaatg 6300 ccatgtcctc ttatgtgccc aacaccctgt ccgtatatca caacttgtta attttagagg 6360 catcgtttcg gaaaacatac ctacagcttc aagttcgtcg tcaaaagtat atggctttct 6420 atgtctcact attggtgtgg aacttttact ttggctatcg cgtcttttat cgcatctcaa 6480 aatactcgtt gattgatttg acttacaaac tttgtctttt atgcggaatt gttacacttt 6540 tgctctttta tttttctgga ttgtatcgga ctacaatagt atatccatca cgttatgttc 6600 aacaagtcaa caaagcgatg aggtttttta acattcgcct tgttataact cctgtcccgt 6660 ggttccaggt gagaaagcct ttggattgtg gtgtccatct tatattatca agcaaacgat 6720 ttgacatatt ggtgatcgaa ggttgggaag cttttcgttc ttcatatttt gcttcaatac 6780 atagaaaaaa caatagcata cagagtaacg agtcctctga atctccttct tctaaacaga 6840 actagattta cttataccct tatcctattt ataaaggatg cgatcgttta tttccttttc 6900 aacgttgtta atgcttttca tgtttatact gttctagtat ttgtcatttt tcataacgta 6960 aattttgatt aaaattttca gctatttttt tttttgctat ccgttgttgc tggcgccttt 7020 cgctatatta ttgatcagtt attgtcgtta tacttttatt acatacttac ccgatttgaa 7080 tttattagga tacttttaag gacatttcct tttatgttgg gatatgagat tgctttacag 7140 acccactgaa ataggattta tcgttggata attaaaaaaa ggatgttgat gattcattac 7200 acatcttgat catttacttg cctcatctta attggaaggg tttaaataaa ggcttaattg 7260 aaagttgctg tcacttaact tccttatctt gttctgtcaa cttaaactat tatctttcat 7320 tcccgactta taatctttct tttctttcta catcaccttt ttttttaaaa aatgggtaaa 7380 aagcgttttc gcatgtacat aagcaaaact tcttctcttc ttatgtagag acttcctttt 7440 tttttaattt tcaacttact catgcggact ataccggacg ttcattagct ctcttgacga 7500 gttaggtttt caaataattt aatataaatg taatcactcc accgttaaaa ttaactattt 7560 ataagtggtg ctaaaatata aaaaagtgca tatagctaac acgtttactc actgttgtgc 7620 tgacaattta atcaatgaaa taattggaga caagtgaact ctttcgaaac tctcataatc 7680 gtcagagttt gacttaaaat acattgtata ttagtagtct aaatacgagt aatattatgc 7740 aaaccttcct attccttatc taatgtcgac tactcagtta aattttatcc cagccaattg 7800 ccctagctaa gacatttgtt attattttgg tattatgttt attctttttg aactttctgg 7860 ctaattgtta aagattttac cttatgtgat ctatattttc ttactggctc aaccatgcgt 7920 aacgctccaa caaccagcac tttgctccat cacaatgccg ttgttcttag aagaacatgc 7980 tgaggtaatt ttatttttaa gatgccgaat taacgctttt agtatttgaa aagatattta 8040 gaacaggcgt tggagccaat gtatgtaatt ttttttgagt tgccaatttg cgtgattttt 8100 ttttttacac gctaaaaaat tgtttatcaa tatgctaacg aaatgactag ttctgatgct 8160 gatgcaagtg ttttatcaga ttatgctatg gcattgttaa ggcacgattc ttctgaagaa 8220 gaagttcgcc agttatgcta ctcacaacta gaagattttt tgcgacagga gacaattcct 8280 tttgttgata aaatttttga tgttttacgt gaaaaatctt acttggaggg tgcttcaaat 8340 atgccgtcaa ccggtatggt gactgaagaa gtttcaaggt attcgccaac ttcatcaatg 8400 atccctgcca ccaacagcat ggaaaccaat tttaataatt ctttacctgc tgtaggaaaa 8460 acaaacactt ttccctctca ggtgcctaat atgtttggac ctccgttgta ccatccagca 8520 gccacagcac cttctgaatt catgcccagt attcctgggt ttggaaactt accaaatcct 8580 gcaatgcctc ccataccatt cttaccattt aatcctgcgg cgcagcctcc tttccctccc 8640 ccatttaaga tgcgaggtaa aagaggattt ggcatgcgcc atgagcataa tagtgaactt 8700 cgtaggcatt ctcctggtaa tcgaagattt aatccataca aagcgtatcc ccaaccccat 8760 ctgggacatc gcttctctcg taacgctggc aatgatccaa caagtactgc tttagaagtg 8820 cgaaacattc cggaagagca ttttaatgag gagaacatta ggtccttttt ttcaaagttc 8880 ggtgtattgg agaaagtcga attaaatccg acacatcatt cttgtgtgtt agaattcact 8940 tcccatgagg ctgccaacaa tgcttggtcc tcgcctgagc ccatatttaa caatcgcttt 9000 attaaaatat tttggtataa tccgtcaaag ggatttcaca atcgaccaaa gaagtttgca 9060 tcccataaat ctcccactac ttccgattcg tcgaatgtag agagttctga agatgtcgat 9120 cctgcttctt tgttacaaaa cgaagagttt cataaactga ttgaagaaag gcaaaggcag 9180 cacgaagaac gtttaaaacg cataaatgct aataaaaagg cactagaaga acttaaccaa 9240 aaaaagcgcg agcttgcaca gcaacaatta aaagaacaag agttactgat gcaaaaaatt 9300 aaggaaactg accgttcagg aaacaaaaga ctcatgttgt tagaaactca gcattctctt 9360 ttgaaggctg aggctgattg cttagggtta cctgtgagca acgtttctga aagcccagcg 9420 gcatctaatg gttctcatca tccttacgct tcaggacttc cccagcgagg taccaacaca 9480 tttttccgtg gcagaggtcg cggacgaggt gatatgtttg cgtcaatgtc catcgataat 9540 cgtccaacta agcttcgtgt aataaatgtt tctcctgaaa aaaatgaagc tttgttgcaa 9600 tacttattca ctgttggagg atatgaggaa attactgaac cttcaactac tgaacgtctt 9660 atcagttttc agaatagaaa ttccgctgaa aaggtatgta gctgattctt tctctgacag 9720 aaaaaatttc aagttaacaa attttagttt tttggtggag ttcggaacgt tgaaaaactt 9780 caagaattgg agttggcgtg ggtgccaaaa acagctgtta caactaatac tacatccatg 9840 gagactggcg aatctaatac aagcgacaac atgaacatag aggtagaaga aggaagatgg 9900 cgctagttta tttactttta caaaagtttt tcagagaatg aattaatggg ctgcattgta 9960 tgcggctgtc ataaaatata agcaactaat tgattaatct tatagagtgc aataagcatt 10020 tcaaaaatgg agatttcata ttgaaatatt tgtaactaac atttcgatca attcggtttt 10080 ttgatacaaa agagttaatg cttccgaatt acaactcaaa tcgttacaca attcattaaa 10140 agtggtaaca aaaatcggct aggagagaaa actcatgata aggaaagaaa cataaattca 10200 gtgttcatag caagaagtaa acaaaatggg catgttactt cagtttagaa ataatggcat 10260 cggtatattg aacattgttt gacttgccgc ccaaatcctt ggtgcgagca tcgggattgt 10320 ttgcaagggt atcaaagata gctaatggta attagtaaac agacaaaatc ttaatttagt 10380 aaaacacata cctgattcga tgcgtttggc ataatcattt aaattcatgt gcttcaacat 10440 cattacagaa gataacagta aagcagtagg gttggctaaa ccttttccag caatatcagg 10500 ggcagtacca tgaacagctt caaagatgga agcttggttg ccaatgtttc cggaaggagt 10560 caaaccaaga ccgccaatta aaccagcgca catatcagaa acaatatcac cgtataaatt 10620 gggcataacc ataactgtgt tgttataagg gacaggatcg gtgacaatct tcaagcaggc 10680 gttatccaag atttcctccc taagctcgat atcaggatat tcaggtgcaa gctccttggc 10740 gcattccaaa aataaaccgt cagccatgcg cataatggta gccttgtgga ctacggtgat 10800 gttgttcttg ccagtttggc gagcatattg gaatgcataa cgaataacac gctcagatgc 10860 tgcgcgagta attaatttaa tcgattgaac aacgcctggt ataacttcat gctcgatgcc 10920 tgagtattca ccctcagtgt tctcacgaat caaaacggta ttaacgttat cataaggtgt 10980 tttgtatccc gtaatagata cacagggacg aacattggca aacaagccga aagtacgacg 11040 caaagtaagg ttcatagaaa catgaccctt cccaattggg gttgccaatg gacctttcaa 11100 agccacttta tttttcctaa cagattcctt agcatcatca ggaatagtag tagtacctaa 11160 acgaattagt aaacgtgatt ttcgtgcgcg ataatctcga ggagacatgg aaggacttga 11220 caagcaggaa caagcattgc tgacaaaaac gtataaaaga aaggccaaac tgcatacaaa 11280 tccaaccatc ttctcttata cttgacatac catttttcaa aataggatat acttttacac 11340 gttcccattc gatagggacc tacaatacaa gtcgttaatg actaaatgac ggatgactcg 11400 acaaaccttt gcagccttaa atatacgttc tacagactga gcaatttctg gaccaatgcc 11460 atcgccagca atcatcgtta ctgtgtagtt cccgttggca ttctttactc cttcatatgt 11520 cccagcggca gccttcgttg aagaaaatct ctgctaaaaa taactctgtt aatataatcg 11580 atcaaataat catgaaaaga cgagtaaggc tgcttaaacc agcgatttat cgcttaggag 11640 ccaattcaca acttacaaaa gagtaacagg cgcttcttga aaacgtccgt aaagaacctg 11700 cagtacgtaa agtagaaagc attgacattg tttttttata actaatgtag catgtatgga 11760 gagtgcaaga tgtcggaccg tgatataaac aaaggattcc gagagtcgtc gcatcatcct 11820 taatttgact ttaccgaatt ttgtggagat agaacgtgga gttaagcaag ggtaattgag 11880 tggagtttaa ccatttagaa agcccctcga agcggaatga ggaattgtta ttacatagcg 11940 ctctttttta ctgcattgtc tattattgcg ttatatagtt tttaacgata atttcagtag 12000 tacataatta ttaatgttgt ttaaaaaaca catctatttg gttcttgagg tatattcagt 12060 aactaaagat gtaattgtct aaattgagag gataattcga cgaattggtt ttgcttgaat 12120 taaaaaaatt gtaattttgt agcttcacac tggtgttatt gatatcttga cttttgtatt 12180 gttctcaact ggaaaattag tgttgtcata tactaggtgt gcttttttaa tttttcggat 12240 tatgctttat tttctcaatt actcttccaa atatattcat tcattcaaca aaaagatgtt 12300 ttgctatttg tcttaaatag tgtagcattt tagaatacgt agttcctatt tcaaactatc 12360 tcaaccatac actcactaaa aacaataacg attattgtgt gttaaaggca tttaaagatt 12420 ttttaggaat agttaaaaaa gcatagtgac atgtaacgaa gcgtactgtt tgcccgcaca 12480 gtcgaagttg ccgcttagaa ttaagcttcg gttaataaaa actagcaagt tatcctaacg 12540 aactgtggga aaagcttatt caggaaaact tcgtggatcc cgttaaaata cgttatgata 12600 actaatagcg aactgtcttg ttgctgtgtt ttgcaatatt acttttaaat agtataagac 12660 agtatgttaa gttaggtttt cagagtgcat actctattcg ttaattcgtg ctttcaactc 12720 tttatctttc aagagtgcaa gaatctcttg caaattcgag cttggtcttg caactgttta 12780 ttctaatcct ccagcgtctt gctggtggtt tcgcatgtct gaacataatt accagtctga 12840 tagggaagtg gcagaggatc cttttcttaa ttatgaagcc tctgctaatc aattatcctc 12900 aaattcgcgc gaatctactc caagaggttc accatggcgc gctggtatga gatccgcatc 12960 tttaatgaca gaacctttag aagattccat gtatagcgat aataattatt tagacaatgg 13020 ggtctctttt acaaaagatg aaaatcctct ttactcgccg tcttggccga gtttggcgga 13080 tgcaaacgtg aattcaatga agtctaataa tgctatacag gagcataaag cagcgaaatt 13140 tgtttctgaa aagtctttgg aaaaagtatc gactgcagat aataaccttg tgcttcagga 13200 gcttgaaaat ctccgagaac gcttaaatca agtagagctt caactcagtg agcgaccctc 13260 ttcctactta ggctatcata acaatcttag tccatatcgt tctcctaaca gttacccttc 13320 tcttttaccc tctactcatt cacctcactc accggcgccg ctaagcacga tgcaaacggc 13380 tcttatgcgg cttcgcactt atcatccttc gcccatcatt ttaaagcccg tagagcaagc 13440 tgtaaaccat gcaatcacct tggtaaacac ctctccatcg agtgtggtgg atgcgttatg 13500 ccgaagcctt gccgaattgt gtcttggctt ggtgcaagaa gcgatcgatg catctatttt 13560 gagtcaacag gaaagctcaa actctttaga tcttgtccgt catacaccac cattgaatta 13620 taccagttct gttgattctt caccacaacg tatggcctct gatagttatg gtaggccttc 13680 tctgcattta aatgacccct ttccatcagt tgatcttcaa tcaaatgaac tttctcatca 13740 taatgttaga acaactctct tttctgatga ttcccgattt cattcaaaaa ttcatacaca 13800 ttctactcct ccttctcaaa tgtatagtgc tgcatctcat ttccggtacc gtagcgatcc 13860 atcaacccgt catgtctcga attctacaaa caaatcgagc ttgcatccat caccaacgtc 13920 tttgcgagtt gctcatccta ttatccccca gagggcgtct ccagcatcac agtcttttcc 13980 ttctcttcaa gacactcctt ccccctagtt cggcctatta caagtttaat tttgaatcaa 14040 tttttctttg tgtttatcaa gtaaatcagg ttcttctcat acatgtaagt tcatacaaac 14100 attgattgag gagtgctatc atttaatttg tcgtccctct cgtacaagtt tttatttttt 14160 ttatatcgct catttcttta agaagttgct aatcctacta ggacgtctat tttaatgtta 14220 ttggatctgg ctgcatctct atttgctgca ttgcttgctc aaactttata gtatgagaac 14280 gtcttaaaat ttgaggtttt gttcatcttc tcatcaatgc tattttttta aaattgataa 14340 ttcagtgcag atcttttcat tatttaacca tatacgataa tttagatttg ggaagtggat 14400 gtcttcttcg caagacgaaa tggtacattg tgtttaatta gctttatttc 14450 //