ID SPBC8D2 standard; DNA; FUN; 43757 BP. XX AC AL022072; XX SV AL022072.1 XX DT 10-MAR-1998 (Rel. 54, Created) DT 07-MAR-2002 (Rel. 71, Last updated, Version 12) XX DE S.pombe chromosome II cosmid c8D2. XX KW adenosylhomocysteinaseS-adenosyl-L-homocysteine; KW alpha-1,2-galactosyltransferase; arginine n-methyltransferase; h4.2; hhf2; KW hht2; histone h3.2; histone h4; hydrolase protein transport protein; KW isoleucyl-trna synthetases; lipoic acid synthetase; KW serine/threonine protein kinase; splicosomal protein; KW U2 associated protein B. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-43757 RA Lyne M., Rajandream M.A., Barrell B.G., Lauber J., Hilbert H., RA Duesterhoeft A; RT ; RL Submitted (03-MAR-1998) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk and QIAGEN GmbH, Max-Volmer-Str 4, D-40724 Hilden, RL Germany XX DR GOA; O13639; O13639. DR GOA; O13640; O13640. DR GOA; O13642; O13642. DR GOA; O13644; O13644. DR GOA; O13648; O13648. DR GOA; O13649; O13649. DR GOA; O13651; O13651. DR GOA; O13656; O13656. DR GOA; O43073; O43073. DR GOA; O43077; O43077. DR GOA; P09322; P09322. DR GOA; P09988; P09988. DR GOA; Q9URT9; Q9URT9. DR SPTREMBL; O13636; O13636. DR SPTREMBL; O13637; O13637. DR SPTREMBL; O13640; O13640. DR SPTREMBL; O13641; O13641. DR SPTREMBL; O13644; O13644. DR SPTREMBL; O13647; O13647. DR SPTREMBL; O13648; O13648. DR SPTREMBL; O13649; O13649. DR SPTREMBL; O13650; O13650. DR SPTREMBL; O13652; O13652. DR SPTREMBL; O43075; O43075. DR SPTREMBL; O43076; O43076. DR SPTREMBL; O43077; O43077. DR SPTREMBL; Q9URT9; Q9URT9. DR SWISS-PROT; O13639; SAHH_SCHPO. DR SWISS-PROT; O13642; LIPA_SCHPO. DR SWISS-PROT; O13651; SYIC_SCHPO. DR SWISS-PROT; O13656; OM40_SCHPO. DR SWISS-PROT; O43073; YGW2_SCHPO. DR SWISS-PROT; P09322; H4_SCHPO. DR SWISS-PROT; P09988; H31_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c8D2 is overlapped at the 3' end by cosmid c17A3 CC (also overlaps with cosmids sequenced outside te EU consortium). XX FH Key Location/Qualifiers FH FT source 1..43757 FT /chromosome="II" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c8D2" FT /map="IIL" FT CDS 1..43 FT /codon_start=2 FT /db_xref="GOA:O13656" FT /db_xref="SWISS-PROT:O13656" FT /note="SPBC568.01, len:13" FT /partial FT /gene="SPBC27B12.13" FT /gene="SPBC8D2.22" FT /product="putative mitochondrial import receptor subunit; FT similar to S. cerevisiae TOM40" FT /protein_id="CAB64681.1" FT /translation="IQQQQQQLAAQTA" FT misc_feature 1..94 FT /note="nominal overlap with c568" FT LTR complement(672..820) FT /note="degraded TF2-type LTR" FT CDS join(1384..1390,1436..1617,2175..3131) FT /db_xref="GOA:Q9URT9" FT /db_xref="SPTREMBL:Q9URT9" FT /note="SPBC8D2.01, len:381, SIMILARITY:Schizosaccharomyces FT pombe, O94456, protein kinase skp1p., (387 aa), fasta FT scores: opt: 1522, E():0, (56.3% identity in 378 aa)" FT /gene="SPBC8D2.01" FT /product="putative serine/threonine protein kinase" FT /gene="pI064" FT /protein_id="CAA17816.1" FT /translation="MSDDSHLETKVVTDGTTGEKKTISYEPCRVLGSGSFGVVIQAKLV FT GTPGFIAVKRVLQDKRYKNRELQIMRAISHPNIIKLIAFFHTHNPSKDETHLCLLLEYM FT PETVFDDMRWYTRRRKSIPNLSIKLYAFQLFRALAYLHSTGVCHRDIKPQNLLVDYKTG FT ILKLCDFGSAKVLVPSEPNVSYICSRYYRAPELVFGATHYTTKIDVWSAACVIAELFIG FT RPLFPGDSSVEQLVEIIRVLGTPSYHEISVMNPNYVNHSLPNVRPHTLESVMPHNCTKN FT AMDLLHKMLTYVPSKRISAIEVLTHPFFDELRDPNCMYHCSRDEGTIERHLPPLFNFNL FT AELSIRPNLNKAILPPHVYESLDVDINNFEPIVVKQADADS" FT misc_feature 1391..1396 FT /note="gtaaat, splice donor sequence" FT intron 1391..1435 FT /note="intron confirmed by EST" FT misc_feature 1422..1435 FT /note="ctaacgatgaatag, splice branch and acceptor" FT misc_feature 1513..1617 FT /note="Match to PF00069 pkinase, Eukaryotic protein kinase FT domain Score 21.98" FT misc_feature 1519..1590 FT /note="PS00107 protein kinases ATP-binding region FT signature" FT misc_feature 1618..1623 FT /note="gtacgt, splice donor sequence" FT intron 1618..2174 FT /note="intron confirmed by EST" FT misc_feature 2160..2174 FT /note="ctaacctagttatag, splice branch and acceptor" FT misc_feature 2175..2912 FT /note="Match to PF00069 pkinase, Eukaryotic protein kinase FT domain Score 262.06" FT misc_feature 2421..2459 FT /note="PS00108 Serine/Threonine protein kinases active-site FT signature" FT CDS join(complement(4536..4628),complement(4356..4480), FT complement(3908..4202)) FT /db_xref="GOA:O43073" FT /db_xref="SWISS-PROT:O43073" FT /note="SPBC8D2.02c, len:170, SIMILARITY:Saccharomyces FT cerevisiae, Q12016, chromosome xv reading frame orf FT yol129w., (184 aa), fasta scores: opt: 276, E():1.3e-12, FT (45.5% identity in 178 aa)" FT /gene="SPBC8D2.02c" FT /product="conserved protein; contains 3 predicted FT transmembrane helices; predicted N-terminal signal FT sequence; similar to S. cerevisiae YOL129W" FT /protein_id="CAA17817.1" FT /translation="MTLLDSSIFRFRLSSLHVSSRSLGVYFAGIMFASAVWVFVDAALY FT SAFDYARNLHITFIDWIPFLCSILGIVIVNSIDKSRLSGDSFAYTDESLARKARFILFI FT GFALLAGGLGGSFTVFILKYVVAGYEGKSLLMGSANIISNILFMISATALWITGNMNDD FT YHYNLQL" FT misc_feature complement(4203..4217) FT /note="ctaacctgattttag, splice branch and acceptor" FT misc_feature complement(4350..4355) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(4481..4493) FT /note="ctgacatttatag, splice branch and acceptor" FT misc_feature complement(4530..4535) FT /note="gtaaat, splice donor sequence" FT CDS complement(7204..7515) FT /db_xref="GOA:P09322" FT /db_xref="SWISS-PROT:P09322" FT /note="SPBC8D2.03c, len:103" FT /gene="SPBC8D2.03c" FT /product="histone h4" FT /gene="h4.2" FT /gene="hhf2" FT /protein_id="CAA17818.1" FT /translation="MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVK FT RISALVYEETRAVLKLFLENVIRDAVTYTEHAKRKTVTSLDVVYSLKRQGRTIYGFGG" FT misc_feature complement(7228..7512) FT /note="Pfam match to entry histone PF00125, Core histones H FT 2A, H2B, H3 and H4" FT misc_feature complement(7459..7473) FT /note="PS00047 Histone H4 signature" FT CDS 7850..8260 FT /db_xref="GOA:P09988" FT /db_xref="SWISS-PROT:P09988" FT /note="SPBC8D2.04, len:136" FT /gene="SPBC8D2.04" FT /product="histone h3" FT /gene="h3.2" FT /gene="hht2" FT /protein_id="CAA17819.1" FT /translation="MARTKQTARKSTGGKAPRKQLASKAARKAAPATGGVKKPHRYRPG FT TVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQEAVEAYLVSL FT FEDTNLCAIHGKRVTIQPKDMQLARRLRGERS" FT misc_feature 7892..7912 FT /note="PS00322 Histone H3 signature 1, KAPRKQL" FT misc_feature 7898..8254 FT /note="Pfam match to entry histone PF00125, Core histones H FT 2A, H2B, H3 and H4" FT misc_feature 8048..8074 FT /note="PS00959 Histone H3 signature 2" FT CDS join(complement(11416..11485),complement(8908..11360)) FT /db_xref="SPTREMBL:O13652" FT /note="SPBC8D2.05c, len:838, SIMILARITY:Marchantia FT polymorpha, YCF0_MARPO, hypothetical 127 kD protein, (1068 FT aa), fasta scores: opt: 128, E():0.88, (20.1% identity in FT 566 aa)" FT /gene="SPBC8D2.05c" FT /product="hypothetical protein; sequence orphan" FT /protein_id="CAA17820.2" FT /translation="MSKNGAPKYVDGGRKIMDEDLRRDLEILRLILLRLSHAADDTSPL FT DVFNAYESVLRENGLNPARHRSYIRILYRLISSKKLSWNDEWRNLMRRIGFSQVSSDLN FT TPLFPLNNTDMENDPFIVNGDDYRSRSNQQKSSQFASEVAQTIKSQTAMFRRADQYRSQ FT KDKILLANSLDFMLEKYRYYKKIDAVYLRKADAVYRAFIMLKYFPRWVQKLRNIQSRIY FT SAGEAYRLILIGQMVNRWRQKTRERLHQKLRFQKNAFLLDVLLKWSALTVNWNRKHEYM FT LKRRVFTNWMSKRRRNESLIQKANVFFQHSVLAHSFKTWKANLSIKNAATLYEKKVVFM FT SFNRWHANYESHVLDLQKAELFSQKAYYSIALHKWKLRIEELSDLMNKADDLYEVNLLQ FT RMLVLWRRKATTYEKIDFWMDGHDVDIVKSAFFKWKNKFIKVDRNFELADTILQNTFLT FT KWRLAVRVKVVQEKRNKDRLIVTFRFWYYLMKAKSFQHKRDHRLLTIAWEAWKDNYQRR FT IKLQKEAQELQLTRIQKIAKQYLIKWRISLLDIKELSIRAEKLHTTNEIIGVWNQWVVS FT YNRKVGMQQNADLFFKRKTLRVVFEHWRYLRETNMLLRLENKVVDFREVQSEKLVLRCW FT NAWVARLLSVSQMLDTAELSTQKVVVRAYEAWSFRYNHQKEIMSQADQFYNERLMRSAM FT VFWRYQLRAIKFYFNISDWKRREFNRQTLRNAFDAWHLLMFRVTSLVMQADRFHEQKKN FT KLLGKYFRKWLQRMQLNQEESSLLEAEATIEGNRTSRYMHTFDTTLPMQNDEFTDESVN FT FENRWKQELKTPISRFSKFLRPIPPNTR" FT misc_feature complement(11361..11379) FT /note="ctaacttactggcatttag, splice branch and acceptor" FT misc_feature complement(11410..11415) FT /note="gtatga, splice donor sequence" FT CDS 11850..15044 FT /db_xref="GOA:O13651" FT /db_xref="SWISS-PROT:O13651" FT /note="SPBC8D2.06, len:1064, SIMILARITY:Saccharomyces FT cerevisiae, SYIC_YEAST, isoleucyl-tRNA synthetase, FT cytoplasmic, (1072 aa), fasta scores: opt: 4526, E():0, FT (60.4% identity in 1067 aa)" FT /gene="SPBC8D2.06" FT /product="putative isoleucyl-tRNA synthetase, cytoplasmic" FT /EC_number="6.1.1.5" FT /protein_id="CAA17821.1" FT /translation="MSFNVPKEEEKIVEFWREIDAFHTQLKLSQGRPTYTFFDGPPFAT FT GRPHHGHLLASTIKDSVTRYACLKGYHVERRFGWDTHGLPVEHEIDKKLGITGSDDVMA FT MGIDKYNAECRKIVMTYASEWRATVERLGRWIDFDNDYKTLYPSFMESVWWVFKELHTK FT GKVYRGYRVMPYSTACTTPLSNFEAQQNYKEVPDPAIVVAFQSISDPEVSFLAWTTTPW FT TLPSNLALAVHPDLQYIKILDKDSNKKYILMESCLGILYKNPKKANFEILERFQGKALD FT GQKYEPLFPYFKSTFGERAFKLYSADYVEEGSGTGIVHQAPAFGEADYDAAWAAGIIDA FT DHQPPCPVDEQGLLTSEITDFAGQYVKDADKEIIRSLKASGHLVKHSQIFHSYPFCWRS FT DTPLIYRAVPSWFVRVKEITNEMVENVMSTHWVPQNIRDKRFANWLKNARDWNISRNRY FT WGTPIPLWVSDDYEEVVCIGSIKELEELSGVSNITDIHRDSIDHITIPSKKGKGTLHRV FT SEVFDCWFESGSMPYASRHYPFERIEEFKHGFPADFISEGVDQTRGWFYTLTVLGTLLF FT DKAPYKNVIVSGLVMAEDGKKMSKRLKNYPEPNLIIEKYGSDALRLYLINSPVVRAEIL FT KFKEDGVREVVTRVLIPWWNSYKFFEAQAALYKKVTGKDFVFDDAATLSSNVMDRWILA FT RCQSLIGFVDEEMKQYRLYTVVPQLLGLIEEMTNWYIRFNRRRLKGEDGEIETINALNV FT LFEVLFTLVRIMGPFTPFITENIYQHLRNYMPIDKNEISLRSVHFLPFPTYKSELDDET FT VLRRVKRMQTIIELARYVREQNNISLKTPLKTLIVILTNEEYLEDAKLLERYIAEELNV FT REVVFTSNEEKYGVVYSVQADWPVLGKKLRKDMARVKKALPNVTSEEVKEFQKNKKMVL FT DGIELVEGDLQIIRSVEVKNEFLKSNTDGICIVLLDIEIDAQLQAEGLAREVINRVQRL FT RKKSNLQVTDDVRMTYKIKNDTIGLESAVDSNEALFSKVLRRPIEKETGADESNIIASE FT EQDVQGATFLLSLLRL" FT misc_feature 11880..13961 FT /note="Pfam match to entry tRNA-synt_1 PF00133, tRNA FT synthetases class I; similar to S. cerevisiae ILS1" FT CDS join(complement(17520..17627),complement(17376..17472), FT complement(17230..17317),complement(15302..17030)) FT /db_xref="SPTREMBL:O13650" FT /note="SPBC8D2.07c, len:673, formed by merging entries FT SPBC8D2.07c and SPBC8D2.08c" FT /gene="SPBC8D2.07c" FT /gene="sfc9" FT /product="putative RNA polymerase III transcription factor FT TFIIIC subunit; by similar to human hTFIIIC90 subunit; no FT apparent S. cerevisia homolog; predicted C-terminal zinc FT finger (by eye)" FT /protein_id="CAA17822.2" FT /translation="MGKDVALDFLPSSLYSCTCSCDGKLAFCDSEKVQILVPSTEANTP FT KFMKALAYLDDVEDELPNCQMLAPNELRLGDLTPSVISRYVVWSPTGLADNYDPLLTVL FT TNRHRVYFFSSSSRVLHQKWTCVAQMSTHLPSDPLELCRIHSVAWSPLVSLPSSSPWGV FT CLFALGAESGHVHLSIMSHSSTPFFKSFDLNCSWVVQLSFSSWNVVGDSATCLLSCSSR FT NGEIRILKIAISSHSDTFDTAMQELPFSLDYRPFSPLLAWSSPLANVEYLALVYPGHLF FT AFRYDKSLGKFCSFLNHNLLSLCSPSGVLFGHNDIDTIYVYILTHSGTLETFSLLDNSI FT SMLDSPERHVLEKFLNNHLQNYGSVSDDSIKTLKIHGFCPSPYLSSAALHFSISYPASF FT TYVVTAAERSYFNFIPSLFSKSVFSHMITSSLNNLCVAPSAGCLLEISLMNDTLKEKTD FT IFTMLTNSLSSFLVTDYDFFLELKHLIDISSLSNLYLDSSLNAMRLLYGWSVYKQKALD FT ATLLNSLRYRLTLYIMLYTLSQISLDPSYLTSDCKAVLRNFVSFTYKELAEVPIAMEVA FT NEIAKSLEVSSDFSETCPACEATVQFNNTSLATCDNGHVWRRCSVTMLLLSQKAAKYCA FT VCNSIVAIFNPSQTKCLLADLQNELSICFYCGGHFLVS" FT misc_feature complement(17031..17042) FT /note="ctaatcagctag, splice branch and acceptor" FT misc_feature complement(17224..17229) FT /note="gtatgt, splice donor sequence" FT misc_feature complement(17318..17333) FT /note="ctaacgtgttttacag, splice branch and acceptor" FT misc_feature complement(17370..17375) FT /note="gtatgt, splice donor sequence" FT misc_feature complement(17473..17486) FT /note="ctaattcccttcag, splice branch and acceptor" FT misc_feature complement(17514..17519) FT /note="gtacat, splice donor sequence" FT CDS join(complement(18186..18413),complement(18005..18112)) FT /db_xref="GOA:O13649" FT /db_xref="SPTREMBL:O13649" FT /note="SPBC8D2.09c, len:111, SIMILARITY to N-term FT of:Solanum tuberosum, Q41499, spliceosomal protein., (231 FT aa), fasta scores: opt: 322, E():1.2e-16, (51.5% identity FT in 97 aa)" FT /gene="SPBC8D2.09c" FT /product="U2 b'-like spliceosomal protein; similar to S. FT cerevisiae MSL1; U2 snRNA-associated protein; putative role FT in pre-mRNA splicing" FT /protein_id="CAA17824.1" FT /translation="MNQNTLYVNNLNDKINKNDLRTALYMLFSTYGTVVDIVALKTPKM FT RGQAHVVFFDPSAAAIAMKALKNFIFFGKEMKIQYAHSKSKIIERIVAENDSRGPLKRL FT RDEADLE" FT misc_feature complement(18113..18129) FT /note="ctaacatctttaataag, splice branch and acceptor" FT misc_feature complement(18180..18185) FT /note="gtatgc, splice donor sequence" FT misc_feature complement(18180..18398) FT /note="Pfam match to entry rrm PF00076, RNA recognition mot FT if. (aka RRM, RBD, or RNP domain)" FT CDS join(complement(20916..21057),complement(20506..20601), FT complement(19033..20426)) FT /db_xref="GOA:O13648" FT /db_xref="SPTREMBL:O13648" FT /note="SPBC8D2.10c, len:543, SIMILARITY:Homo sapiens, FT O60678, protein arginine n-methyltransferase 3, (512 aa), FT fasta scores: opt: 888, E():0, (37.7% identity in 528 aa)" FT /gene="SPBC8D2.10c" FT /product="putative arginine n-methyltransferase" FT /protein_id="CAA17825.2" FT /translation="MLVKPMACYFEIWTRKVTTIEDFSLAIANRFKQMGSHSDSEVDWD FT NEEEVWEDEVHEFCCLFCDSTFTCLKDLWSHCKEAHNFDFYQVKQQNNLDFYACIKLVN FT YIRSQVKEGKTPDLDKLSDILRSDEYMISVLPDDSVLFSLGDELDSDFEDDNTLEIEVE FT NPADVSKDAEIKKLKLQNQLLISQLEEIRKDKMNELTSQTTDQLSVTPKKADNDSYYFE FT SYAGNDIHFLMLNDSVRTEGYRDFVYHNKHIFAGKTVLDVGCGTGILSMFCAKAGAKKV FT YAVDNSDIIQMAISNAFENGLADQITFIRGKIEDISLPVGKVDIIISEWMGYALTFESM FT IDSVLVARDRFLAPSGIMAPSETRLVLTATTNTELLEEPIDFWSDVYGFKMNGMKDASY FT KGVSVQVVPQTYVNAKPVVFARFNMHTCKVQDVSFTSPFSLIIDNEGPLCAFTLWFDTY FT FTTKRTQPIPEAIDEACGFTTGPQGTPTHWKQCVLLLRNRPFLQKGTRVEGTISFSKNK FT KNNRDLDISVHWNVNGKADSQSYVLN" FT misc_feature complement(20427..20447) FT /note="ctaactttggttctattgtag, splice branch and acceptor" FT intron complement(20427..20505) FT /note="confirmed intron" FT misc_feature complement(20500..20505) FT /note="gtatga, splice donor sequence" FT misc_feature complement(20602..20615) FT /note="ctaactcttaatag, splice branch and acceptor" FT intron complement(20602..20915) FT /note="confirmed intron" FT misc_feature complement(20910..20915) FT /note="gtatga, splice donor sequence" FT CDS 22284..22652 FT /db_xref="SPTREMBL:O13647" FT /note="SPBC8D2.11, len:122aa" FT /note="SPBC8D2.11, len:122, SIMILARITY:Staphylococcus FT epidermidis., P95734, fema., (422 aa), fasta scores: opt: FT 114, E():0.43, (22.6% identity in 93 aa)" FT /gene="SPBC8D2.11" FT /product="hypothetical protein; sequence orphan" FT /gene="pI054" FT /protein_id="CAA17826.1" FT /translation="MGRPLIESSSNDHVANFNRKTKKLIDQALEHYNGRLPEQLENFSF FT ENFVEVLDTESSVVNRVFEVLVREVAGSFRQRKRAHMPRTNTTAQVVQRQLAPSISTVF FT SRDSNDPLVDDMDQEYIL" FT CDS join(complement(24192..24291),complement(23772..23835), FT complement(22990..23707)) FT /db_xref="SPTREMBL:O43075" FT /note="SPBC8D2.12c, len:265, SIMILARITY:Aquifex aeolicus., FT YF75_AQUAE, hypothetical proteinaq_1575., (249 aa), fasta FT scores: opt: 449, E():7.8e-22, (36.8% identity in 250 aa)" FT /gene="SPBC8D2.12c" FT /product="conserved protein; possibly mitochondrial protein FT synthesis; DUF28 domain" FT /gene="pI053" FT /protein_id="CAA17827.2" FT /translation="MNALNKIPFTRALYHFSRFRSFTTSGWIMSGHNKWSKIKHKKSAN FT DQARSLQIGKLSQGIILAVRQEGANPELNMRLATLLESAKKISMPKSGIENAINRGLGT FT AGSEGSQVHFIEYEAMHPSGVGLIVEAVTDNRARAASSIKHILRNHGASLSTVKFLFSK FT KGKVEVNLPPEKRDSMKFEDVLDDAIEAGAEDIVNRPKEYIDEEDEGEFLILTEPSSLN FT QVAHHFRSKNYEIKDSRLIHIPLEETAIDVPAKDSVREDIQKLIDDLYENEDVMFIHLS FT ILNSHFLPILDE" FT misc_feature complement(23443..24195) FT /note="Pfam match to entry PF01709 DUF28, Domain of unknown FT function, score 477.00, E-value 1.6e-139" FT misc_feature complement(23708..23728) FT /note="ctaatattactgtgtatccag, splice branch and acceptor" FT misc_feature complement(23766..23771) FT /note="gtaagg, splice donor sequence" FT misc_feature complement(23836..23848) FT /note="ttaacctttatag, splice branch and acceptor" FT misc_feature complement(24186..24191) FT /note="gtaagt, splice donor sequence" FT CDS join(24816..24890,24933..25000,25090..25417,25463..26199, FT 26251..26398) FT /db_xref="SPTREMBL:O43076" FT /note="SPBC8D2.13, len:451aa, SIMILARITY: YIL104C, YIK4_YEA FT ST, P40486, hypothetical 59.2 kD protein, (507aa), fasta sc FT ores, opt:269, E():7.1e-30, (31.1% identity in 472 aa FT overlap)" FT /gene="SPBC8D2.13" FT /gene="pI052" FT /product="hypothetical protein; similar to S. cerevisiae FT YIL104C (null lethal)" FT /protein_id="CAA17828.1" FT /translation="MITPKFELRQDEEFVYLDVHTPYIKAKNVEIDAFNNEVNFCIAPY FT FLKLELPGNVLDDDRANASYDISSGFVHIKFPKETPGEVFPDLDLLTTLLVNQNKEPVK FT KPLIEEVEDTPSPSTSQNASKDEEKEVKIDWQNIHFDDPDFDWGLLQRLDDEKMQYTST FT SQYGFNNQYSGLLKYNALVGNEINQIPEPERTPPSTRSEIRVQLEDEKFDAEHYMADFY FT DREMIDEILHYIPDYIGEFLLVQQGKSDRLLEFTSEEKEALAKLPKRSYLIDNPKNVYL FT CLVPLIFAYAYDNRTTLGDPTIESCWNIGTLSSTISCLDTNFLAIKDIFIACIRRSLAY FT PLYRNWDLALTCWKDTHAILSLGKRWILRVLLRIRNLFEHHDVYYIYNAIVLNDYAYWI FT QTANDNVLAALAYQVSECTITKEETNWPLEEIEANVQETIIASDEESESIEK" FT misc_feature 24891..24896 FT /note="gtatgg, splice donor sequence" FT misc_feature 24920..24932 FT /note="ctcaccaaggcag, splice branch and acceptor" FT misc_feature 25001..25006 FT /note="gtaagt, splice donor sequence" FT misc_feature 25073..25089 FT /note="ctaactttttcccaaag, splice branch and acceptor" FT misc_feature 25418..25423 FT /note="gtttgt, splice donor sequence" FT misc_feature 25447..25462 FT /note="ctaactttatcattag, splice branch and acceptor" FT misc_feature 26200..26205 FT /note="gtaagt, splice donor sequence" FT misc_feature 26227..26250 FT /note="ctaaagactcaccaataattttag, splice branch and FT acceptor" FT CDS join(complement(27522..27720),complement(26700..27430)) FT /db_xref="GOA:O13644" FT /db_xref="SPTREMBL:O13644" FT /note="SPBC8D2.14c, len:309, SIMILARITY:Drosophila FT melanogaster, Q24509, integral membrane protein sed5, (310 FT aa), fasta scores: opt: 711, E():0, (41.5% identity in 316 FT aa)" FT /gene="SPBC8D2.14c" FT /gene="sed5" FT /product="putative golgi syntaxin (T-SNARE); similar to S. FT cerevisiae SED5" FT /protein_id="CAA17829.1" FT /translation="MSFQDRTAEFQACVTKTRSRLRTTTANQAVGGPDQTKHQKSEFTR FT IAQKIANQINQTGEKLQKLSQLAKRKTLFDDRPVEIQELTFQIKQSLSSLNSDIASLQQ FT VVKGNRNKPAQMNQHSENVVVSLQNSLANTSMTFKDILEIRTQNMKASQNRTEKFVASS FT SMNANPLINSGNSISPFADYNDPKPEANEDYLSLNLGDGANTRYEQMALLESQTDTYSQ FT QRMSSIQNIESTITELGGIFSQLAQMVSEQRETVQRIDMHTDDIVSNIGSAQREIVKFY FT ERMSSNRALLFKIFGIVIIFFLLWVLVT" FT misc_feature join(complement(27522..27672),complement(26712..27430)) FT /note="Match to PF00804 Syntaxin, Syntaxin Score 62.17" FT misc_feature complement(27431..27445) FT /note="ctaacatttctttag, splice branch and acceptor" FT misc_feature complement(27516..27521) FT /note="gtaagt, splice donor sequence" FT misc_feature 28018 FT /note="Real end of Cosmid c17A3" FT CDS join(28990..29037,29079..30143) FT /db_xref="GOA:O13642" FT /db_xref="SWISS-PROT:O13642" FT /note="SPBC8D2.15, len:370, predicted transit peptide FT 1-22aa, SIMILARITY:Saccharomyces cerevisiae, LIP5_YEAST, FT lipoic acid synthetase, mitochondrial , (414 aa), fasta FT scores: opt: 1485, E():0, (66.1% identity in 336 aa)" FT /gene="SPBC8D2.15" FT /product="putative lipoic acid synthetase, mitochondrial; FT similar to S. cerevisiae LIP5" FT /protein_id="CAA17830.1" FT /translation="MLKIGRNATILKNNFWFASVRFQSGGFSEKLAKGPSFADFLNMDK FT PLTADEAFELDRKVELPNGSIHKRLPSWLKTKVPLGTNFNRIKHDLRGSHLHTVCEEAK FT CPNIGECWGGKDKSRATATIMLMGDTCTRGCRFCSVKTSRRPGPLDPNEPENTAEAIKQ FT WNLGYIVLTSVDRDDLTDLGANHIAKTIQKIKEKAPHILVEALTPDFSGRMDLVEIVAK FT SGLDVFAHNVETVEELTPFVRDRRATYRQSLSVLKHVKKTCPHLITKTSIMLGLGETDA FT EILTTLKDLLEHNVDVVTFGQYMRPTKRHLKVQEYVHPKKFEYWKEVAEKLGFLYVASG FT PLVRSSYKAGEYFMENLIKKRSGNPASMSV" FT misc_feature 29038..29043 FT /note="gtgagt, splice donor sequence" FT misc_feature 29065..29078 FT /note="ttaatatagcatag, splice branch and acceptor" FT CDS join(complement(31304..31429),complement(30439..31260)) FT /db_xref="SPTREMBL:O13641" FT /note="SPBC8D2.16c, len:315, SIMILARITY:Homo sapiens, FT CAB53671, hypothetical 43.8 kD protein, (389 aa), fasta FT scores: opt: 394, E():1.1e-19, (30.8% identity in 263 aa)" FT /gene="SPBC8D2.16c" FT /product="conserved protein; similar to S. cerevisiae FT YMR310C" FT /protein_id="CAA17831.1" FT /translation="MEKESEIQSLPPTRRYTISLALPISSLNVAYNLQLKTSFVWKISR FT IVSLYGIDEIILLEDPEYVQNTQVHTLSSDAYLKDPTKFLTDLLCYFETPFFMRKELFP FT LNPHLKYTSCFPLLPLRNDKASTVNIEFPYREGIVTHPSPQAKNKYIINAGLSHNVIVS FT SPSVLAPRTRVTVRLKAQSPNEEGQLQGDIVSFSAPREKGGHYWGYKVRSCLSSQLCKS FT SPYKGGYDFVVQINSQTSAITSKELEASLPSSFRHAVLVLQDNVVQKELVDSTAKSISF FT NPFPVSFLNDPIPEEILLAAMTRLSDMLLMHGRR" FT misc_feature complement(31261..31276) FT /note="ttaactcaaaatatag, splice branch and acceptor" FT misc_feature complement(31298..31303) FT /note="gtttga, splice donor sequence" FT conflict 31832..31852 FT /note="this is a run of 21 Ts in this cosmid, but 22 T's in FT c213 and c17A3" FT /citation=[1] FT CDS 32875..33930 FT /db_xref="GOA:O13640" FT /db_xref="SPTREMBL:O13640" FT /note="SPBC8D2.17, len:351, SIMILARITY:Schizosaccharomyces FT pombe, O94622, putative galactosyltransferase., (375 aa), FT fasta scores: opt: 480, E():1.3e-24, (32.4% identity in 253 FT aa)" FT /gene="SPBC8D2.17" FT /product="putative alpha-1,2-galactosyltransferase" FT /protein_id="CAA17832.1" FT /translation="MFNFRLFSRRGKSLGLLAIVLLLFGFYSLKSSMPVYSNSIGSPSA FT HSSSYKGVSKAKTSPQDPDSVVMLIVSFDDHYDSSRSDSSSVFLDKVLSDRTEYALRHG FT YTLVHKKARDIQARYGVYGTWSIIPALRETLAEYPDAGWIWLLDAKAVIMNPSESLKDR FT VLKPEKLSQHLLLNSPIDPLKNYIRTRRKMDPSDVFVITTSDYNGISTRSLLIKNNNFA FT PFLLDAWNEPLLKSAGFDQAERSALSHLLEAHNTILDHVALVSPKVLNSYTNSAVDLNY FT EEGDFLVILQDCENAAACERIFEYVFYLSSWSLVFLLTLPATTINRENFQPLKSSFRKK FT RLMNNRRLVLS" FT CDS complement(34359..35660) FT /db_xref="GOA:O13639" FT /db_xref="SWISS-PROT:O13639" FT /note="SPBC8D2.18c, len:433, SIMILARITY:Rattus norvegicus, FT SAHH_RAT, adenosylhomocysteinase, (431 aa), fasta scores: FT opt: 2236, E():0, (78.0% identity in 428 aa): NOTE The gene FT is described in Abe and Shimoda (2000), Genetics 154 FT 1497-1508. They describe it as ORF SPBC8D2.18c, and as a FT kinase homologous to S. cerevisiae IME2 and S. pombe FT pit1.mde3 gene described in this paper actually corresponds FT to SPC8D2.19" FT /gene="SPBC8D2.18c" FT /product="putative adenosylhomocysteinase" FT /EC_number="3.3.1.1" FT /protein_id="CAA17833.1" FT /translation="MATQNYKVADISLAAFGRKELEIAENEMPGLIAVREKYAKSQPLK FT GARIAGCLHMTIQTAVLIETLVALGAEVTWSSCNIYSTQDHAAAAIAATGVPVFAWKGE FT TEEEYLWCIEQQLKSFPSGKPLNMILDDGGDLTALVHERHPELLVDIRGISEETTTGVH FT NLYKMFKENKLKVPAINVNDSVTKSKFDNLFGCKESLVDGIKRATDVMIAGKVAVVAGF FT GDVGKGCSTSLRSQGARVIVTEVDPINALQAAMDGFEVTTMEEAVKEGQIFVTTTGCRD FT IIRGEHFNEMKEDSIVCNIGHFDVEIDVAWLKANAKDVVNIKPQVDRYELKNGRHIILL FT ADGRLVNLGCATGHPSFVMSCSFTNQVLAQIALWTDNTSYPLGVHMLPKKLDEEVARLH FT LGKLGVKLTTLTSVQSDYLGIPVDGPYKADHYRY" FT misc_feature complement(34536..35642) FT /note="Match to PF00670 AdoHcyase, FT S-adenosyl-L-homocysteine hydrolase Score 995.46" FT misc_feature complement(34971..35021) FT /note="PS00739 S-adenosyl-L-homocysteine hydrolase FT signature 2" FT misc_feature complement(35385..35429) FT /note="PS00738 S-adenosyl-L-homocysteine hydrolase signatur FT e 1" FT CDS join(36146..36292,36339..36413,36547..38004) FT /db_xref="GOA:O43077" FT /db_xref="SPTREMBL:O43077" FT /note="SPBC8D2.19, len:559aa, SIMILARITY: YJL106W, FT SME1_YEAST, P32581, meiosis induction protein kinase sme1, FT (645aa), fasta scores, opt:338, E():7.7e-28, (28.4% FT identity in 617 aa overlap), SIMILARITY:Schizosaccharomyces FT pombe, O14132, putative serine/threonine-protein kinase FT c3c7.06c, (650 aa), fasta scores: opt: 871, E():0, (34.6% FT identity in 488 aa)" FT /gene="SPBC8D2.19" FT /gene="mde3" FT /product="serine/threonine protein kinase; putative FT positive regulator of meiotic genes; similar to S. FT cerevisiae IME2; meiosis specific transcription" FT /protein_id="CAA17834.1" FT /translation="MSNESIYSVLDLTQVIFEDRYLVKQKLGDGSFGTVYLAQRKEKNG FT LYETVAVKKLKNSSKPKPKHELLKLRESLALRKISKHPCLIDLLETFMDPYRNIFLVME FT FMDCNLFQLFKRRQGRLFTKETAFNILLQIISGIEHIHKHGFMHRDIKPENILVKRISP FT KPISSRYSIKLGDFGLARPSVSSDPLTEYVSTRWYRAPELLLRSGSYNHSVDLYAFGCI FT VFEIYSLKPLFPGRNETDQLNRVCEILGNPGIDELDTLHYWSQAKELAKRLGFMLPPTK FT PYPIQKLLPQNCPEGHAKMIPCLLAWNPDVRPTAKYCKEVFFPLPPSASKSNSVPQKIS FT NPKVEQNLGFPISREDKKSTRRVGWLKKNLSEFVSSVKSVFPDSHGSQPHVKTEKPINA FT KESTGHLANPIASSNVPAISLKPGELHESVFFSENEQIDYLLTSIDYLPSYKPPSNGSN FT IAINAFNETVGDRIPSSKDILITEKIPFKKENEIRDSIVPSCSQPDESNKEGVASCLLL FT QKSGMEMTSVLEYSTPNPAEVQNICNDHAKFETSKSLHLSSP" FT misc_feature 36206..36280 FT /note="Match to PF00069 pkinase, Eukaryotic protein kinase FT domain Score 21.53" FT misc_feature 36224..36301 FT /note="PS00107 protein kinases ATP-binding region FT signature" FT misc_feature 36293..36298 FT /note="gtaaga, splice donor sequence" FT misc_feature 36324..36338 FT /note="ctaacaattgtgaag, splice branch and acceptor" FT misc_feature 36414..36419 FT /note="gtaagt, splice donor sequence" FT misc_feature 36536..36546 FT /note="ctaacaaaaag, splice branch and acceptor" FT misc_feature 36550..37293 FT /note="Match to PF00069 pkinase, Eukaryotic protein kinase FT domain Score 179.02" FT misc_feature 36760..36798 FT /note="PS00108 Serine/Threonine protein kinases active-site FT signature" FT CDS complement(38526..42200) FT /db_xref="SPTREMBL:O13637" FT /note="SPBC8D2.20c, len:1224, SIMILARITY:Saccharomyces FT cerevisiae, WEB1_YEAST, web1 protein, (1273 aa), fasta FT scores: opt: 1064, E():0, (27.5% identity in 1349 aa)" FT /gene="SPBC8D2.20c" FT /gene="sec31" FT /product="putative COPII coat component; WD repeat protein" FT /protein_id="CAA17835.1" FT /translation="MRLKDISKTATLAWSPRGVNDNQALLALGGYTGTEGSKNSDTLLE FT LWNENPESQKPVGSIDVKTRFYDLAWEKSLDKPMGVIAGSLEDGGIGFWDPAAILKSDE FT ASASIATYKSENGSILGPLDFNRLQPNLLASGDNKGDVWVWDIKHPQQPFALPKQNRSS FT EVHVVSWNNKVSHILASGNATEYTTVWDVKLKRQVLNLSYLGAAGVSAATGAVNSIAWH FT PNNATRLATAIDDNRNPIILTWDLRQPTVPQNILTGHQKAALSLSWCPEDPTFLLSSGK FT DGRAMVWNVETGESLGSFPRSGNWYTKSSWCPSNSNRVAVASLEGKVSIFSIQSTNTDK FT SQEASIKGATSIDDNEFFNNLPSIAGSQEPSFSLPLAPKWFKVPVGARFGFPNKIVSFS FT PNSKEVTITSAPDEVEQDEAKSFHSSAKFQTEKEITDFCQKGVEESASEEEAINWKLLM FT AVSKRASRSKFAELLGYKTLKPKNDEDDSKVDESVAKDSTTPNELSKNANNENYDDDSS FT FYGKLAESVQEVSIADKKDAEIVKDSFKIFNPEDSDLEKNITEALLTGDVLSAVKACLE FT EKKISEALFLSTFGGKECRKCVRDAFYELQEHKPSYMRLSACIADNDLQNVVDNAEVSE FT WKDIFVFICTYATDDEFAPLCSTLGQRLEDLEDEKSIRSAEFCYIASKSLQSYANLWLK FT QLATSTKTSKAASAYGAYVEQLTKLMDKVSMFRSIVVYKDDELSATKDWKLAGLYEVYI FT AYAKILSASGKFDDAMSYLNLVPTEFPGAKEEIQRLTMLLEPHAVPPIHQIKQTGYAPV FT QPKTSQASSILPTVPRTTSYTSPYATTSSHITPADVHPLPPPSTSTTAGWNDAPMLGQL FT PMRRAAPSMAPVRSPFPGASSAQPAAMSRTSSVSTLPPPPPTASMTASAPAIASPPPPK FT VGETYHPPTASGTRVPPVQQPSHPNPYTPVAPQSPVAAASRISSSPNMPPSNPYTPIAV FT ASSTVNPAHTYKPHGGSQIVPPPKQPANRVVPLPPTASQRASAYEPPTVSVPSPSALSP FT SVTPQLPPVSSRLPPVSATRPQIPQPPPVSTALPSSSAVSRPPIATSAGRSSTAASTSA FT PLTYPAGDRSHIPGNLRPIYEMLNAELQRVSQSLPPQMSRVVHDTEKRLNMLFDRLNSN FT VLSKPLTDELLALATSLNAHDYQTASNIQTNIVTTLGDQCEHWIVGVTRLITLSKSTT" FT misc_feature complement(41205..41324) FT /note="Pfam match to entry PF00400 WD40, WD domain, G-beta FT repeat, score 2.10, E-value 29" FT misc_feature complement(41331..41375) FT /note="PS00678 Beta-transducin family Trp-Asp repeats signa FT ture" FT misc_feature complement(41334..41435) FT /note="Pfam match to entry G-beta PF00400, WD domain, G-bet FT a repeats" FT misc_feature complement(41466..41594) FT /note="Pfam match to entry PF00400 WD40, WD domain, G-beta FT repeat, score 2.30, E-value 28" FT misc_feature 43017..43757 FT /note="nominal overlap with cosmid SPBC17A3, EM:AL109652 S. FT pombe chromosome 2" FT CDS complement(43110..43757) FT /codon_start=1 FT /db_xref="SPTREMBL:O13636" FT /note="SPBC8D2.21c, len:215, SIMILARITY:Saccharomyces FT cerevisiae, YPL063W, Q02776, similar to caenorhabditis FT elegans celf45e12_5 f45e12.1 gene product., (476 aa), fasta FT scores: opt: 424, E():3.1e-19, (38.9% identity in 208 aa)" FT /partial FT /gene="SPBC8D2.21c" FT /gene="SPBC17A3.01c" FT /product="conserved protein; similar to S. cerevisiae PSR1; FT possible plasma membrane phosphatase involved in sodium FT stress response" FT /protein_id="CAA17836.1" FT /translation="DPYHVSISAVLTRESSKYEKGKVIKDLSYLNRDLSRVIMIDTNPE FT SWSKQPDNAIAMAPWTGNPKDKELVGLIPLLEFIAIMDIKDVRPVLKSYQGKNIPLEYA FT RREEKLRTKLIEDWNEKKKKGSSFLFGGRSVSEEPPKLIIDIQRERQKAAYAEFKKYID FT ENGPKMLEEEKAREAEQKTSIFNLLFHPEEVQQQQLEQMQQQQFSPETNASK" XX SQ Sequence 43757 BP; 13886 A; 8048 C; 8184 G; 13639 T; 0 other; gatccagcaa caacaacagc agttggctgc gcagactgca taaagaactc attttttcaa 60 tactttcctt acgatacgct tgtctagcga ctgctagaac ggctgagaga tgaaaaaaaa 120 aataagagag caaaaaggta aagaaaaata caagatacaa tttttttttt aaaactcctg 180 ggaaatgatt catccttctt tcttcttgat ggtcaaaatt ctataggttt aagcttaagc 240 ttgtttgaga gctttttttt cgaaatcttt atttcatatt atatttttat ttgtactttt 300 tttttgggtt ccctattttg tcttcgtctt ctgtagggtg ttttttgggg gacgtttaaa 360 agaaggaaaa aaaaactttt ttttcattga tgataatttt gaatgaacct ttcaaataaa 420 attcatgtct aatggtggca ttattttgag ttttgcataa gattatggga cattgaatct 480 tttctaatgg agtaaaagat ctcttggaca agctcacttc attttccttc ctaccatgga 540 gccatgttct cttaatatat acttaataaa tctttgtgtt tgtgctttta tttatattga 600 tgaatgtcaa agagtgtggg gacatgtaga gtttttagtg taaatgcttg tgttttatgt 660 atatgtacac gttctaatat gtacgtacat ttttcgataa gcttgtattc tttttcattt 720 tgcatattca aacagatatt aaactatgta tgtatagaac atgtgtatgt ttattcttcc 780 tactaaacaa gttatgatat agaaaggtgt agtgaagaaa cagaaacgac caattgagtt 840 cggtatggag gaagctcgta agaaaatgag aatgaacctt tcattagagc agaaaacaaa 900 tccctactaa tttgatgctc tcgtttagct tgtatgccat gtagtaagtc attagtccat 960 tgaacccatc ccttcgttaa ccatctccaa aatgcaaacc catataatga gatgagtaat 1020 taatatgaaa taatacaata atctattaaa tatttaaata catgaaacta taaccgccca 1080 cctagtatat tgtatccaga aaccagcatc ttctacattc tacaaatagt gagcatatac 1140 tatgtatccc tattgtacta taacctagca ttaacaaact cgttgccctg ttttatttat 1200 ttacctgcca tagcatttcc acctcatctc tgcaatctaa accccctcct ctggctgttc 1260 cctgctactg gcattattta cagcgctgga cacctacctc cccacattga cgtaaacaca 1320 ccaaaaccag tgccattcaa ccattttata gtcgctaaga accaaacaca catatttcga 1380 gaaatgagtg gtaaataaga aaaatttaaa ggatttcagt actaacgatg aatagatgac 1440 tctcatttag aaactaaggt cgttactgat gggactaccg gagagaagaa aacgatctct 1500 tacgaaccat gtcgagtact gggatcgggt agttttggag tcgtcattca agcaaaatta 1560 gttggcactc cggggttcat tgctgtgaag cgtgttttgc aggacaaacg ctacaaggta 1620 cgttgttgag gtgtttgcat gcgcgaaatc gctgtaggaa ggaggcggtg attgaaatga 1680 ggaaaggagc gtgcaagagt ggagttttca tgtgtggttg aaagaaatct cttttggctg 1740 atctgctttt aatgccacct ttctttgaaa cagccggtga taaatatttg ttgatactag 1800 cgttggtttt cctttacaca aaagagaatt ctatctattt cacgttgcat cgagtggttt 1860 gctttttgag cttttgggtt tacttctttt ttacctttta tacttctttc tgtacttttt 1920 atctcttctt tttgttcctt aggttgattt gtatatggaa tctttttttt aataaatcaa 1980 ttttgaaagg gcaacggatt atccttttcc tattgcaatg agtttttatt ctcaccagat 2040 tgcgcgtcga ggcgtcttta aatcattcgg cgtctttttt tttaacacca cttacaataa 2100 atgctctctt gcaacatctc cttttttttt tcatcttcct tgcctttttt gccagcatac 2160 taacctagtt atagaaccgc gagcttcaaa ttatgcgagc aatttcccat ccaaacatta 2220 ttaagcttat cgcctttttt cacacccaca atccttcaaa ggatgaaact cacctttgtc 2280 tgctcttgga atacatgcca gaaactgttt ttgatgacat gcgttggtat actcggcggc 2340 gtaagtcaat acccaacctt agtataaaac tttatgcgtt tcaattattc cgcgcgcttg 2400 cctatctgca cagtactggt gtttgtcaca gagacatcaa gcctcaaaat cttttagtcg 2460 actacaagac gggcatttta aagttatgtg actttggtag tgccaaagtc ctcgtccctt 2520 cagagcccaa tgtttcttac atttgctctc gctattatcg agctcctgaa cttgtgtttg 2580 gtgctactca ttacaccacc aaaatcgatg tttggtcggc tgcttgcgtt atcgcagaat 2640 tgtttatagg ccgtcctctg ttccctggtg acagtagtgt cgagcagttg gttgaaataa 2700 ttcgagtact tggtactcct tcatatcatg aaatctctgt catgaaccca aattatgtta 2760 atcattcttt gcccaacgtt cgacctcaca ctctcgagag tgtgatgccc cataactgta 2820 caaagaatgc catggatcta ctacacaaaa tgctaacgta tgttccgtcc aagcgtatat 2880 ctgccattga agtccttact catcccttct ttgacgagct tcgtgatcca aattgcatgt 2940 accattgttc acgtgacgaa ggtaccattg aaaggcattt gcctccttta ttcaacttca 3000 atttggctga actatccatt cgtccaaatc tcaacaaagc aattttaccc cctcatgttt 3060 acgaaagtct cgatgtggat attaataact ttgaacctat tgtagtcaaa caggctgacg 3120 cagactcata actgttttca gctttagctt tattgcataa ttcatgtagc tctttcactc 3180 ttttcacttt tggagttttc acagttatcg attctttgct tggtaaaagg atttataggt 3240 taaagatttg atttttttaa tattttttaa tcggaattat tatttattca taagcaaaac 3300 ctttccttct tttttcgatt ttacactcct tatgaaatta ctcttatcct gttaattgtt 3360 ttaatgcctt gttgctagta tatatttggg attcttctaa ttaattaata aggcgtctct 3420 gaaaatgtca gtccttttat ttgtctatac ataagcacga tggaattagc aagaaagcat 3480 ttgtacatat tagttctttg ccaataccta gctttggtac tatttgacat gacatctatg 3540 tgaaaggtct gccttttcaa agaaaccgac ttttagccaa gggtctactg acattatcaa 3600 ttaaatctct caccaatgtg tagaaagttt aaaccagctt tacgtcttgt aataaatata 3660 aaataatcaa caaataaaaa ttcaacatac ttttcaaaat attaaattga ataaaaaggg 3720 ctcataagac gaattttaaa gctaaataca ccgaaataga caattatagg atggagctaa 3780 gggacgatag ttcaacgata gaaaagagga agcgtttaat attggcaagc aaaaaataaa 3840 agcagcagat gatgagagat taggaaaatt tagaccatcg tgactatgaa gtgtcaaacg 3900 catcccttca aagttgcaaa ttataatggt aatcatcgtt catgttaccg gtaatccaca 3960 aagcggtggc actgatcata aaaagaatat ttgaaattat attggcagag cccataagta 4020 aagatttacc ctcatatcca gcaacaacat attttaggat aaaaacagtg aaactgccgc 4080 caagaccacc tgcaaggaga gcaaacccga taaaaaggat aaatcgtgcc tttctggcaa 4140 ggctttcgtc ggtgtaagca aaagaatcac cactaagacg ggatttatca atggaattaa 4200 cactaaaatc aggttagcta aagagaaagc aaataactta tggaaactat cggtcatcac 4260 agcaaacggc ttcagaaaca cattggatta tgggcacaaa agtcatattt ggcaacacgc 4320 agatgtccaa actaaggtaa aatttataaa cttacatcac aattccgaga atggaacata 4380 gaaaaggaat ccagtcaatg aatgtgatat gcaaattcct tgcataatca aatgcgctat 4440 ataaagccgc atcgacgaat acccatacag cagaagcaaa ctataaatgt cagttgataa 4500 ataaaatgct aaaacgacta ttctgagtta tttaccataa ttccagcaaa gtacacgcct 4560 aatgacctgg atgaaacatg taaagaggat aaccgaaatc ggaagattga tgaatcaagt 4620 aaagtcattg taatttaagg aaaacaatta ttgcgtcttt ctacgtttaa gatggaaaac 4680 tggtgtaaat gacagagatt ttttgacaaa gtgttatgga aggataatta ttagaaagct 4740 ccaatttttt ctaataacaa gtaggcaatg tagagatgca aactattatt tttcgcaata 4800 ggaggactta aagatcctaa gaaaaagttt tttatgtttt actcgtgaac aagttaaagt 4860 tgagtcattc ctaccttctc atgatggtac gtccaccata ctacaccacg aggtagcatt 4920 tgaaggcatg tgttacttga tgcaaaaatc gagattttga tcaaaaacta tggaatttgg 4980 gagtgtatga gtgataataa ctaaggagca taaaatcctg aaggaaattt ctattcaaat 5040 gttaaagcag gatgtttagt gaaaaggaaa ggtcgggaag caatgtttac ttaagtagtg 5100 tacatatatg aaatagaatc tatacttctg cttcagtaat ttggaaacat actctgaaat 5160 tcctatactc tcgttaaaga aaggctttca agattcaacg gtacttaaaa tagcaatgga 5220 aaagagcgaa atttagtagc ctgtccgtgt gtcaaatcaa gctactaggg catgtgctgc 5280 aagttacgat aacgtaatta tttaattagt aaaagatata attgaatcca tcgggtgaag 5340 gagactttta gaatgcggaa agtggacgag aggaggcaat gaaaacacaa aatacgaaat 5400 acatctataa agggtgcaag aagaagcact ggcattcctt tctttaaaaa cttacgttac 5460 atttatcttc tcagtagaag gaaggaatgt ttgcacattg gcggacttta gactttgata 5520 aattcttcga gagctcagag ttaagtttaa aagtatttct ataggttttc aaaactttct 5580 ctatagagtt aaatattttt aaaaaccaac aagaaatcgt ttttttttta ttttcattca 5640 gaggaataga catgttttac tattacaagt ttaaacttgt aattgacttt aagcaatctc 5700 gcttcgctta accttaaact tgcaaactca ctcaaacaca caaggttggg aattaggcgt 5760 ctataataag ttagaaaagc aggactcgca ttgttttgag tgtctaaaac ttaatcacaa 5820 tgtctcaaaa tgtatctgtc aaacacacaa agaattcaag gacaataaac tgttgcagga 5880 caggcagagc attgtaccgt gttctatcaa cggcgctttt agggcaactt gtgaaacggc 5940 taaagtgtgt tgaagacaaa atcaagtgaa agagcaagta ttaaaaaagg gtaaataaaa 6000 ataaaagaaa gaaaagttat tttaatttaa aaactaacga acaaaaacct tttaagtaaa 6060 taagaaaagt ataattcagt agtgtaaaaa tctaataaac actgtttcaa tgtactaata 6120 atctgtgtat atactttcta tttcatatta ttaatatcat agagcaaaaa tggtggcatt 6180 tttattgaaa atcgctgcat atgttcctgt tgttcatcgc ttttattaat cacgtatgtt 6240 aacagactga acggaaaaga gcagaagctt gtttaatttg atttgaactt ccgcaattgc 6300 ataattgcca catttctcta tctgacattg ctctctttat tattatttga ttgtttcatt 6360 tgcttggcta tggaagttca taaattagta ggaggacgtg ggctatttcg agatgaaagc 6420 gaaatttcac tctttacgct tctcaattcc gacagagtga taaaacggtt tgccaaatgc 6480 ccgtctatcg ctattggcga cagtgtacca aagacatcca gttttgcttc acctaccgat 6540 acactaagat actcagctga aaaatttgct tcgagaatcc gcttttcctt aaaatacagt 6600 cacatcgttt atcaaaaatt atagccacaa tacgtgagta ataaattcac gcacagatga 6660 gtttccctgt tgggaaaaga agacagcttg ctttcagtac atttacctta caatcagctt 6720 gtagagttct ctttgtataa tataaataga tgggttcgtg cccaattttt tctcaaattg 6780 aagcctacaa tatattagca tagttatgat atgactccaa ccttccaaac atacattaat 6840 gaaacgtgat aactacaggc taaatttgtg tgttttcttg tcctcccccc cataaatgtt 6900 agataaaaac aatttattta tttatttcta aaaacagagc ttactcccag agtaagtcag 6960 acacaaggtt gggtaaaaat ttctcagacg tgcaatccat aatgaaagaa aaacaaatcc 7020 cttcaataaa attgcatttc ttcaaggaaa accaaccatt ttcgtgcaaa taaatattca 7080 ttgaatggat attaaaagag aaatgagtaa agataaaaag agaaacaact attaatatgc 7140 aaagtaggaa aaaaagaaaa agaaaataca attcacttca atatcgaaaa gtgtgcaacc 7200 agtttaacca ccgaaaccat aaatggtacg gccttgacgc ttcaaagagt agacaacgtc 7260 caaggaagtg acagtcttac gcttggcgtg ttcagtgtag gtaactgcat cacggataac 7320 gttttccaag aaaagcttga gaacggcacg agtctcttcg taaaccaaag cagaaatacg 7380 cttaacaccg ccacgacgag caagacgacg aatggcaggc ttagtaatac cttgaatgtt 7440 atcacgaagg atcttacgat ggcgcttagc accacccttt cccaatcctt taccaccttt 7500 tccacgacca gacatcttat atgagtaatg ggattcctgt aagttcaaac aaactgacta 7560 ccaattgatc aatttacaat atcaaaaact aattttcaag cgcaaacact gaaattccta 7620 tgatttgaat ttcaatggct tctcgtacta gtcgtagtag ttactgtgta agtgctgtag 7680 ttaggcgtcc atctccatat atatatacat tttttcaggt agcggggaag ccgaaatcgc 7740 aatcttaaat cagggttagg gttgtgattg actgaggtat atatagcagg aagtgtccac 7800 acccgacgtg gaaagaacct ttttgtaagt ttatttaccg aattacgtta tggctcgtac 7860 caagcaaact gctcgtaaat ctaccggtgg taaggcaccc cgtaagcaat tggcctctaa 7920 ggctgcccgt aaggccgctc ccgctactgg cggtgtcaag aagcctcatc gttatcgtcc 7980 tggtactgtc gctcttcgtg aaatccgtcg ttaccaaaag tctactgaat tgttgattcg 8040 caaacttccc ttccaacgtt tggtccgtga aattgcccaa gattttaaga ctgacttgcg 8100 tttccaatcc tccgcaattg gtgctcttca agaagctgtc gaggcttatc ttgtctctct 8160 cttcgaagat accaatcttt gcgctatcca tggcaagcgt gttaccattc aacccaagga 8220 tatgcaattg gcccgtcgtc ttcgtggcga acgctcttaa atgcattgat tgcctaatat 8280 tttatttggt atattgtgtt tattgggttt aagttttgca tttcctaatt ttttcaatca 8340 ttgtcatgta tatttccttg gtttaatgtc gggtttagca tattaatttt tatgtttttg 8400 ctttctcact tgacttattc tgaaacactg ttttaaagct ttgtagtttt taattttttt 8460 tcctttgtta atctgttttt attaatttaa atagtttttt ttttattata cgtatttcat 8520 ttttgtaaat ttttcattgt aagaaaaaaa tttttttttt aaatttgttt gaccgcctgc 8580 tactgtaagt cgtagtactt gctttgaaca tcttatggag cattactctc ctaacgattt 8640 ggtaaagtcc ttttaaaatt atcaagtgaa gcgttcactt cctgcttaaa gttttttttt 8700 ttttttttta agtattccac acgtacttgt aatgtgttgc aggattattg atgctactgt 8760 tacacgaatt ttcgactatg tattaaactt ttcaaagcaa tgactattat attatacata 8820 tctaaaggtt tatcaatata ctctcaactc atttcaaatg gttagataaa aaaaaagaga 8880 actaactctc tccgtcaatc gtaaatgtca acgggtatta ggaggtatag gccgcagaaa 8940 cttggaaaat cgagatatgg gagtctttag ttcctgcttc cagcgatttt caaaatttac 9000 agactcatca gtgaattcat cattttgcat tggcaaagtg gtatcaaatg tatgcatata 9060 gcgtgaagtg cgattgccct caatggtagc ttctgcctct agtaatgatg attcttcttg 9120 attaagttgc atacgttgca accattttcg gaaatatttg cccaataatt tatttttctt 9180 ttgctcgtgg aacctatccg cttgcattac taagctagta actcggaaca tcagcaaatg 9240 ccaggcatca aacgcatttc gcaacgtttg tctattaaat tcacgacgct tccaatcact 9300 aatattgaaa taaaatttta tagcacgcaa ttgatatcgc caaaaaacca tggcagaacg 9360 cattagtcgt tcattataaa attggtctgc ctgagacatt atctcctttt ggtgattgta 9420 acgaaaagac catgcttcgt acgctctaac gacaactttt tgcgttgaga gctctgctgt 9480 gtcaagcatt tgagaaaccg acaataaccg cgctacccaa gcattccagc atcgcagcac 9540 aagtttttct gattgaactt ctcgaaagtc aacaactttg ttttccagtc gtaataacat 9600 attagtctca cgaaggtatc gccaatgttc gaatacaact cgcaaagtct ttcttttgaa 9660 aaataaatca gcattttgtt gcattccaac ctttcgatta taagacacta cccattgatt 9720 ccaaacaccg ataatttcgt tagtagtatg aagtttttcc gcgcggatcg atagctcttt 9780 aatgtccaat aatgaaatac gccatttgat tagatattgc ttagcgattt tttgaattct 9840 tgttagttgt aattcttgag cttctttttg tagtttgatt cttcgttgat agttgtcctt 9900 ccaagcctcc caagcaatag ttaatagtct atgatctcgc ttatgttgaa aagacttagc 9960 tttcattaaa taataccaaa atctgaatgt gacaattaga cgatctttat ttcttttctc 10020 ctggactacc ttaactctca cggccagtct ccattttgtc aaaaatgtat tttgtaaaat 10080 cgtatcagcc agttcaaaat tcctgtcaac ttttataaat ttatttttcc atttaaaaaa 10140 agcagactta acaatatcaa catcatgtcc gtccatccaa aaatcaattt tttcgtaagt 10200 tgtagctttc cgtctccata agacgagcat tcgttgcagc aagttaactt catataaatc 10260 atcagctttg ttcattaaat cagataattc ttcaattcga agtttccatt tatgtaaagc 10320 gatactgtaa taagcttttt gggagaataa ttcagctttc tgtagatcca aaacatgtga 10380 ctcgtaattg gcatgccatc tattaaaaga cataaataca actttttttt catataatgt 10440 agcagcattc ttgatggata agtttgcttt ccaagtttta aaagaatgag caaggacaga 10500 atgctggaaa aacacatttg ctttctgtat aaggctttca tttctccttc tctttgacat 10560 ccaatttgta aacacacgac gttttaacat atactcatgt tttctattcc aattgaccgt 10620 taatgctgac catttaagca aaacgtctag caaaaacgca ttcttttgaa atcgcaattt 10680 ttgatggaga cgttctctcg tcttctggcg ccaacgattt accatttgac ctattagtat 10740 caatctgtaa gcttctccag cactatatat tctagattga atgttcctta gcttctgaac 10800 ccaacgtgga aaatatttaa gcataataaa ggctcgataa acagcgtcag ctttacgaag 10860 atagacggca tcaatctttt tataatatcg atatttttca agcataaagt ctaaactgtt 10920 tgctaataaa attttgtctt tttgagaccg atattggtcc gctctgcgaa acatggcagt 10980 ttgcgacttg atcgtttgag caacttcact agcaaactgg gatgatttct gctgattact 11040 cctcgatcga taatcatcac catttacaat aaatggatca ttttccatat ctgtgttatt 11100 aagcgggaaa agaggtgtat tcaaatctga ggaaacttgt gagaacccga ttcgtcgcat 11160 caagttcctc cattcatcat tccagcttag tttttttgag gagatcaatc ggtaaagaat 11220 acggatataa gaacgatgcc tcgcaggatt tagaccattt tctcgaagga cactttcgta 11280 tgcgttgaaa acatcaagag gggaggtatc atcagctgcg tgacttaaac gaagtaaaat 11340 tagtcgcaat atttctaaat ctaaatgcca gtaagttagc aaaaaataaa agcaaattcg 11400 tattaaaatt cataccacga cgcaagtcct cgtccatgat ttttcgacca ccgtcgacat 11460 acttgggagc gccatttttg ctcatgatct tacaagtctt ttattaaaca catcacaaag 11520 aaagctcagt gaataccaaa tgaatcaaga cttttaagat ctgtttgttt acggctaagt 11580 tctgttcatc aacgaactgt ttactgtact cgactaaatg cgttaagata catatcacag 11640 tgtgcagcct ttgcgctaga caaacaacac agtttaccaa attacattga attttttagc 11700 aaattgtatc ggatttgatc gcaatcaatc tgaatacaaa attgttttgt gtacatattc 11760 ctctccttcc acacctaaac ttcttgtaag accgatttcc ggaagcattg ctgaattagc 11820 tcttttgcct accgtaaaag tatttcagca tgtcgtttaa cgttcctaaa gaagaggaaa 11880 aaatcgttga gttttggcgc gaaatcgatg cgttccatac tcagttaaaa ctttctcaag 11940 gtcgtcctac ttatacattt ttcgatggac ctccattcgc taccggtcgt cctcatcatg 12000 gtcatctttt ggcttctacc attaaggata gtgtcacccg ttatgcttgc ttgaagggtt 12060 atcacgtcga gcgtagattc ggttgggata cacatggact tcctgttgag catgaaatcg 12120 acaaaaagtt gggtattact ggaagtgatg atgttatggc tatgggtatt gacaaataca 12180 atgccgaatg tcgtaaaatt gtcatgactt atgcatccga atggcgtgca acagttgaaa 12240 gactgggccg ttggattgat tttgataacg attataaaac gttgtatcct tctttcatgg 12300 aaagtgtttg gtgggttttc aaagagttgc atacaaaagg aaaagtttac cgcggatatc 12360 gtgttatgcc ttactcgact gcatgtacaa cacctttgag taactttgaa gctcaacaaa 12420 actataagga agtcccagat ccggctattg ttgttgcctt tcaatccatt agtgatcctg 12480 aagtttcttt cttagcttgg actactactc catggacctt gccttctaac cttgctttgg 12540 ctgttcaccc tgacttacag tacataaaaa ttttggacaa ggattctaat aagaaatata 12600 tccttatgga gagctgcctt ggcatccttt acaagaaccc aaaaaaggcg aactttgaaa 12660 ttttggaacg tttccaagga aaggccttgg atggtcaaaa gtatgaacct ctcttccctt 12720 atttcaagag cacttttggc gaaagagcat ttaaattata ttctgctgac tacgttgaag 12780 aaggcagtgg tactggtatc gtccatcaag ctcctgcttt tggtgaagca gattatgacg 12840 ctgcttgggc tgctggcatc atcgatgctg atcaccaacc tccttgccct gttgatgagc 12900 aaggtttgct tacttcggaa atcacagact tcgctggcca atatgttaaa gacgcagata 12960 aggaaattat ccgctccttg aaagcatctg gccatttggt taagcatagt caaattttcc 13020 atagttatcc attttgctgg cgttccgata cacctctaat ttatcgtgcc gttcccagtt 13080 ggtttgttcg cgtgaaggag atcactaatg agatggttga aaatgtcatg agcactcact 13140 gggtccctca aaacattcgt gataaacgtt ttgcgaattg gttgaagaat gctcgtgact 13200 ggaacatttc ccgtaacaga tactggggta cccctatccc actttgggtt agtgatgact 13260 acgaagaagt cgtttgcatt ggttccatta aggagcttga agaactttcc ggcgtttcta 13320 atattacaga cattcatcgt gacagtattg atcatatcac tattccttct aaaaaaggta 13380 aaggaacatt gcatcgtgtc agtgaagtat ttgactgttg gtttgaatct ggcagcatgc 13440 cttatgcttc tcgtcattac cctttcgaaa gaattgagga attcaagcat ggcttccctg 13500 ctgactttat ttccgagggt gttgatcaaa cccgtggatg gttttatact ttaactgttt 13560 tgggaacttt gttattcgac aaagcacctt ataaaaatgt aattgttagt ggtctggtaa 13620 tggctgagga tggtaaaaaa atgtccaaac gtcttaaaaa ttaccctgaa ccaaatctca 13680 tcattgaaaa atatggttct gatgcccttc gtttgtatct catcaactct ccagttgttc 13740 gtgctgagat tcttaaattt aaggaagatg gtgtaagaga agttgttact agagttttga 13800 ttccttggtg gaacagttat aagttttttg aggcgcaagc tgctctttac aagaaggtta 13860 ctggtaaaga ctttgttttc gatgatgctg ccactttgag ttccaatgta atggatcgct 13920 ggattttagc tcgttgccag agcttgattg gatttgttga tgaagaaatg aaacaatacc 13980 gtttgtacac cgtggtccct caacttctcg gtttaattga ggagatgact aactggtata 14040 tccggtttaa cagacgtcgt ttgaagggtg aagatggtga aattgaaact attaatgctt 14100 tgaacgtttt gtttgaagtc ttgttcacgt tagttcgtat tatgggccca ttcacccctt 14160 tcattactga aaacatttat caacacctta gaaactacat gcctattgac aaaaatgaaa 14220 tttcacttcg ttcagttcat ttccttcctt tccctactta caagtctgag cttgatgatg 14280 aaactgtttt acgccgtgtt aagcgtatgc aaactattat cgaattggcg cgttatgttc 14340 gtgagcagaa taatatttct ttgaagactc ccttaaaaac ccttattgtt attctcacta 14400 acgaagaata cttggaagat gctaagctct tagaaagata tattgcagag gagcttaacg 14460 tccgtgaagt agttttcacc tccaatgaag agaagtatgg agtcgtatac agcgttcaag 14520 cagattggcc tgttttgggt aagaagcttc gcaaagatat ggctcgtgtt aagaaggctc 14580 taccaaatgt tacttctgag gaagttaaag agtttcagaa gaacaagaaa atggttttgg 14640 atggtatcga acttgtcgag ggagatttac aaattattcg ttctgtggag gttaagaacg 14700 agtttttgaa atcgaacact gatggcatct gtattgtttt attagatata gagatcgatg 14760 ctcagttgca agctgaaggt ttggctcgcg aagttatcaa ccgtgttcaa cgtttgcgca 14820 agaagagcaa tttacaagtt acggacgatg ttcgtatgac ttataaaata aaaaacgata 14880 ctattggtct cgaatctgct gtagattcca atgaagcctt attttcgaag gtattgagaa 14940 gacccatcga aaaggaaact ggtgctgacg agtcaaacat aattgcttcc gaagaacaag 15000 acgtgcaagg agctaccttc cttctcagtc ttcttaggct atagaaatag ttcaacttca 15060 gcagaagtat tctttctcaa aatttgtagt cttaggaatg tatctcgact cctacgtttt 15120 gtttattatt ttataatata atggattttc ctatgtacta ctcctgattt atgtagtgag 15180 aaatatttaa gaagggtttt gattgtcaaa aaaaataata aatattattt acacacgtaa 15240 caaaagaaaa taatgtttca ccggatatgt tataaaatat ttttgataaa tggatggaat 15300 attacgaaac caagaaatgt ccaccgcaat agaagcaaat agaaagctca ttttgaagat 15360 ctgcaagtaa gcatttggtt tggctagggt taaaaatggc cactatactg ttgcacacag 15420 cacaatattt cgcagctttt tgagataaaa gtagcatggt gactgagcaa cgtctccaga 15480 cgtgtccatt atcacatgta gctaatgatg tattattgaa ttgaactgta gcttcacatg 15540 ctgggcaagt ttcactaaaa tctgaggaaa cttccaagct ttttgctatc tcgttcgcta 15600 cttccattgc aatcggtacc tcagccaact ctttataagt aaatgataca aagtttctta 15660 aaacagcttt gcaatcacta gttagataag aggggtcaag agatatctga gaaagtgtat 15720 ataacataat gtatagggtt aatcggtatc tcaaagaatt cagtaaagta gcgtctaatg 15780 ctttttgttt ataaacgctc caaccatata aaagtctcat tgcattcaat gaagagtcta 15840 aatacaaatt tgaaagagag gatatatcta taagatgctt tagctcaagg aaaaaatcat 15900 aatccgtaac taaaaaactt gataaggaat ttgtaagcat tgtaaaaata tccgtttttt 15960 cttttaatgt gtcattcatt aaagaaattt cgagtaaaca accggctgaa ggtgctacac 16020 ataggttatt aagtgaagaa gtaatcatgt gtgaaaaaac ggattttgaa aaaagagatg 16080 gaatgaaatt aaaataactt cgttcagctg ctgttacaac gtaagtaaat gaggccgggt 16140 acgatatact aaagtggaga gcagcagagg ataagtaagg agaagggcaa aagccatgga 16200 ttttaagggt ctttattgaa tcatctgaaa cagagccata attttgcaag tgattgttca 16260 aaaatttttc aagcacatgt ctctctggtg agtccaacat cgatattgaa ttatccaaca 16320 aggaaaaagt ctctaaagtt ccagaatgtg tcaagatgta aacatatatg gtatcaatgt 16380 cgttatgacc aaacaacact ccagaaggag agcaaaggga caaaagatta tggttcaaaa 16440 aagagcaaaa cttccctaat gacttgtcat accgaaatgc aaataaatgg ccaggataaa 16500 ctaacgcaag gtattcaaca ttggctaatg gagatgacca ggctagcaga ggagaaaacg 16560 gtctatagtc caacgagaaa ggtagctctt gcatagcggt atcaaaagtg tcagaatgag 16620 agctaatagc tatttttaaa attcggattt ctccattccg agaagaacac gatagcaaac 16680 aggtagctga atccccaacc acattccagc tggagaatga taactgaact acccatgagc 16740 aattcaaatc aaaagacttg aaaaatgggg tagatgaatg tgacataata gagagatgga 16800 catgacccga ctctgcacca agtgcaaaca aacacacgcc ccaaggtgaa gatgaaggaa 16860 gacttaccaa aggcgaccat gcaacgctat gaattcggca aagttccaaa ggatcggaag 16920 gtaagtgagt actcatttgt gccacgcaag tccatttttg atggagaacg cgactagatg 16980 aagaaaagaa atacacacga tgacgattag ttaaaacagt taacaatgga ctagctgatt 17040 agcgttcaaa taaaaagtag aatagagaaa caaaaccgaa taagacttta ttttaggcat 17100 tgaaacgata aacaaacttt aaaaaatgaa acaaatttca taaaaataga aatatttacg 17160 cacaaaaaca caaaccgagt ggaatgttaa gtaaagtcaa actcaagtct tctcttttta 17220 agaacatact cgtaattgtc tgcgagacct gttggcgacc agaccacata gcggcttatg 17280 acacttggag ttagatctcc taaacgaagc tcattagctg taaaacacgt tagcttttat 17340 actctcataa gcatcaaagg gcattgggaa catacgagca agcatttggc aatttggtag 17400 ttcatcttcc acatcatcta aataggctag cgccttcata aacttaggcg tattggcttc 17460 agttgaaggt acctgaaggg aattagctag tctcgaacac gtcaatttga gatatgtacc 17520 aagatttgga ctttttctga atcgcaaaaa gccaattttc catcgcaaga acaagtacag 17580 ctatacaagc ttgatggaag aaaatccaat gctacatcct ttcccattgt aagaaagacg 17640 acgagcgatg ttgaagccag gtgaacaatt ccatcaaatg cgttaaagtt cagtgccttg 17700 cgcaatgcta gttgagaaag acttgcatga aaaatccact aaaatagctg taaacaagat 17760 gatattggac tagaattttg cttcatctta taaaacttag caacaatgcg atggtgttat 17820 cggtccgctt tactgtctgc aaacactgac acctgaaaca actaaaacca acaggtatat 17880 acagtgaaga acaaaaagag agaaaaagga aaaccactct ttataactct cttgactcca 17940 acaggatccc gaaaaaagtt accctatata aaacgataat tgtgaatttt agaaaatgta 18000 cagtttactc aaggtcagct tcatcacgta gccgttttaa aggacctctg ctgtcatttt 18060 cggcgacgat tctttcaata atcttacttt tcgaatgagc gtattgaatt ttcttattaa 18120 agatgttagt caatcgtttt tgttttttta tggggattaa tgagaaagct catttcacag 18180 cataccattt cctttccgaa gaatatgaaa ttttttaagg ccttcatcgc aattgcagcg 18240 gcagagggat caaagaatac aacatgagct tgacctctca tcttgggagt tttcaacgcg 18300 acaatatcaa ccacggtccc ataagtggag aatagcatat atagtgctgt tcttaaatca 18360 tttttattaa ttttatcatt caaattattc acataaagtg tattttgatt cattttcgcc 18420 ctagtttggt gttttgcaaa tgctgaactc tttaccttat atttttacct gcaaacactg 18480 cgcgctaaca atcgctatga gttaacttat tgaatggatt gttgaaaagg ctcgtcttaa 18540 ttacattaaa atgctaaagc ttttacattt ttaatttatc ttttaaggct ataaatatcc 18600 atatttaatt ttccggaacg aaatatgttt atttgcaatt ctacgaccat tgaacgctag 18660 tcatctgaat tatgattcaa gtcacaatta tttttagaga tcccttaaat ataatcaaat 18720 cgtaacaaaa aatcaacgat aataatagtt cacgttaaaa atctttccca agcattgtgc 18780 agttgttgat agtttaatcc ttatgtactc aaatttccat atttaaaaga ttgaaaaaat 18840 gttatttttt agtagtatag aaaatagaga atattttaag actagatgat tttttcgatc 18900 caccgtattc ccactctggg gaaataattt tacaggaaat gccttaaaac cccagcaaga 18960 ttcctaatcc aaaaacctac agcatagtaa cattaatcag taattctata tttttaagta 19020 aagactttga tcctaattca acacgtagct ttgagagtca gctttcccat ttacattcca 19080 gtgaaccgaa atgtccaaat cacgattgtt ttttttattt tttgaaaagg aaatagttcc 19140 ttcaacacga gtgccttttt gaaggaaagg acgattacgt agtaacaaaa cgcattgttt 19200 ccaatgagta ggagtgcctt gagggcctgt tgtaaatcca caagcttcat caatagcttc 19260 tggaataggc tgtgttctct tagtcgtaaa atacgtatca aaccataaag tgaaagcaca 19320 aagcggtcct tcgttgtcta taattagaga gaagggggaa gtaaaactga catcttgaac 19380 tttgcacgta tgcatattaa accttgcaaa aacaacaggc ttggcgttaa cataagtttg 19440 aggaacgact tgtacactaa cacctttata agaagcatcc ttcatgccat tcattttgaa 19500 accatacaca tcgctccaga aatcaatagg ttcttctaac aattcagtgt ttgtggtagc 19560 tgtaagtacc aatcgtgtct cggacggtgc cataattcca gaaggtgcaa ggaagcgatc 19620 tctggcaaca aggacggaat caatcatact ctcaaacgtt agagcatagc ccatccattc 19680 cgaaataatg atatctacct tgccaaccgg taaactgata tcttcgattt ttccacgaat 19740 aaaagtaatt tgatcagcaa gaccattttc aaaagcattt gagatagcca tttgaatgat 19800 atcggagttg tccacagcat aaaccttctt ggcgccagcc tttgcgcaaa acatggataa 19860 aatgccagta ccgcatccta catccaaaac cgtttttcca gcaaaaatat gcttattatg 19920 ataaacgaag tcacggtatc cctcggtccg gacagaatcg tttagcataa ggaaatgaat 19980 atcatttcca gcgtaagact cgaaataata agaatcgtta tctgctttct ttggggtaac 20040 tgatagctga tctgtagtct gactagtcaa ttcattcatt ttatcttttc gaatttcttc 20100 aagctgagag ataagaagtt gattttgtaa ctttaatttc tttatttctg catctttaga 20160 aacatctgct ggattctcta cttcaatttc gagagtattg tcgtcctcaa aatctgaatc 20220 gagttcatcg ccaagcgaga agagtacact gtcgtcaggg agtacagaaa tcatgtattc 20280 gtcggaccgt aaaatgtcgg aaagtttgtc caaatctggt gtttttcctt ccttgacttg 20340 agaccgaatg taatttacca atttaatgca agcatagaaa tccaaattat tctgctgctt 20400 aacttgataa aagtcaaagt tgtgtgctac aatagaacca aagttagcca tgtatgaata 20460 ttaatagata tacaaaattt ttaaattaaa tagaaaaact cataccttct ttacaatgac 20520 tccataagtc ttttaaacag gtaaaggtag aatcgcaaaa caagcaacaa aattcatgta 20580 cctcatcctc ccaaacttcc tctattaaga gttagtatta actttattgt ttccatttga 20640 aagctgggat gcatcgtctt tcaaagaaag ggtagcagca gaaaaaacga aaaccgtgtc 20700 ccaggggaat tgagcaaatc ctgaataata atgttcaatc caggaaatcg gatcattcat 20760 cattgactga tagagatgaa tatccattca tgtcaagcaa taatcgcaaa aagatagcat 20820 ggaattccag tattaactaa acaagcaaca aattccccca gaagtaaaaa acattgattt 20880 cagaccagta caacagccaa gcatattatt cataccttca ttatcccagt caacctctga 20940 atcactatga gagcccattt gtttaaaacg gttggcaatt gctaaagaaa aatcctctat 21000 tgttgttact tttctcgtcc aaatttcaaa gtaacatgcc ataggtttca ctaacattgg 21060 aacaaaggtt cttaagattg cactaccagc gctttcattg agatcaagtg tgtttttttt 21120 ttaagaactt gatcaactta agcataggtt ttgactcctt gagagaattt tgttgcttca 21180 gatttttggg cctttggagt gatgttagtg gtatttcagc gcgttgtgcg tgcaacagtc 21240 ttggttggca gaaaggatac cattcgaaca gtgaaaaccc attccggcgc taaaaagaga 21300 tggattctta cagaagatgg taaaagcttt aagcgaaagc acgcaggtgc tcaacatttg 21360 aaccgtgaca cgtctagttc aacgagagct agacaacgtc aatgggaaga agcaaataca 21420 atacaaaaac gagtgttaaa gaggcttctt ccttttaaat gagagaatga taaggatctc 21480 tttattaacc ctaatttcat gtacatgaca tggcaaaatt tactttcctg ctttatgatt 21540 attgaaattt ttcaaagcat actttttatg gtcttaaatt ttcagtttat ccttggtggg 21600 ttcgtttgtg gtaggacaaa attgtctatc cttaaggatt ctttcctacc ttatataaat 21660 atccatgcta agatctaact atgttgtctt ctaatgactc gttatactaa acatttcatt 21720 tttatgaatc agcctttttc catcacatga atttgattaa atttaagttg gttttatcgt 21780 tgagttattg actcctgtcc actttctctt aaatacacat agtggtgaag agaaattcaa 21840 agcttatatc tttctcccct ttttacgttt tgacttttat cttgcttacc gttccttttg 21900 aattccataa attgattttc aaattcattg aaagtatgtc aaagtcgcag ttccgtcgga 21960 tttttaacta cagatcatca aaaaactgtt cctaaattaa aaggaactat acggaaattc 22020 ctacaaatag aaatcacaat ttcatggatc ctctttttat ccttcagcgt aagcatcaat 22080 ccctttcttc aagtgtgggt aacatgttac ctgttagtaa cgaattgcaa atttgtgcac 22140 tgaaatttat cattgcttag cctggaggca aggtggtggg acctgcctga ttctccctta 22200 gaaacagcgt atatcacata ttcaattagt attgaaattt tcagagggtc ttgaataaat 22260 tgtcggcgta gcatcttggt gttatgggac gccctttaat agagtccagt tcaaacgacc 22320 atgttgcaaa tttcaataga aaaacaaaga agctgattga tcaagcgctt gaacattata 22380 atggaagatt acctgagcag cttgaaaatt tcagctttga gaactttgtc gaagttttgg 22440 atactgagtc ctcagtggta aatcgagtct tcgaagtact ggtgcgcgag gttgctggtt 22500 cttttcggca aaggaagcgt gctcacatgc ctaggactaa taccactgct caagttgttc 22560 aaaggcaatt agcgcccagt atatcaaccg ttttttcgcg tgattccaac gatcctcttg 22620 ttgacgatat ggatcaagag tacatcttat aaaacatgag actggaatct ttatggaggc 22680 cggaaaagat ggattttgaa gatttgactt ttacttgtct tttgtacttt tctatcacaa 22740 ggtttaatta ttacatgctt tccagtctat gaaataggtg ataatgaact atttatttat 22800 gagcatattt tttaagtcga tcagcaaaaa ccacatagat ttatttaaaa atttaattgc 22860 atcgcaacat tgtttttgta gacgttagag caactagctc atagtttgta agtaatcaaa 22920 tctcatagta ttatatgatt catcaaggag aaaaaagttt catatttttt aattttcttt 22980 tttttaacct tattcatcaa gaataggcaa aaagtgggaa ttcagtatac tcaaatgaat 23040 gaacattaca tcctcgtttt catacaagtc gtcgattaat ttttgaatat cttctctgac 23100 agaatctttt gcaggtacat cgatagccgt ttcttccaga ggaatatgga ttaaacgaga 23160 atctttgatt tcatagtttt tagatcgaaa atgatgagcc acctggttta aactagaggg 23220 ctcggttaaa atcaaaaatt caccttcatc ttcttcgtct atgtactctt tgggcctatt 23280 gactatgtcc tctgcgccag cttcaatagc atcgtcgaga acatcttcaa atttcataga 23340 atctcgtttt tctggaggaa gatttacttc caccttaccc tttttgctaa acaaaaattt 23400 gacagtcgat aaagaagccc catgatttcg taaaatatgt ttgattgaag aagcagctcg 23460 agctcgattg tctgtaaccg cttcaactat aagaccgact cctgatggat gcattgcttc 23520 atactcaata aaatgaactt gcgaaccttc acttccagcc gtacccaatc ctcgattaat 23580 tgcattttca ataccagatt tcggcatgga tattttcttg gcactctcta gtagtgtcgc 23640 cagccgcata ttcaattcag gattggcacc ttcttgtcga actgctagaa tgattccctg 23700 tgaaagtctg gatacacagt aatattagta actgttatta gatagtagtg tgaaacaaga 23760 cgagccctta ctttccaatt tgtaaacttc ttgcctggtc attcgccgat tttttgtgct 23820 taatttttga ccactctata aaggttaata tgcgtatata aaactggtaa cattatagtg 23880 tctatggatc ttataaattc actgttgttg acagtaaccc agtttgcaag aaaacctgaa 23940 cattcactta attgtatgtt cgagcaatta actgaacact ttataaaagt ggatatgaat 24000 acagttcaaa ttttatcact ttcaattctt ctgtcttatg tgaaagatcc cagtaattca 24060 gcaaagaatc atagtcaaca ttgagtagcc tacattcttt actacaatgg gtctcgtttt 24120 ttacttttgt tttatcttga aaattcatag aagcaaaaac actataacta gcttataaat 24180 caataactta ctgttatgcc cagacataat ccatcctgaa gtcgtgaatg atcggaacct 24240 tgaaaaatga tacagcgctc ttgtgaaagg tattttattt aaagcattca ttatccttgt 24300 atgctacgaa gtgaccactg accacaatta ggataaaaca aggaaaactg atatgagagg 24360 agagggagtt gaagtaggga atactagcac tcgaatcagc atctctataa agaaaacagt 24420 atttctgctt tagtagaaat aaattgattc aacaattcgt atataatata ttttactact 24480 tcatatactt taaaccttta agttgttaaa aattgtaagt atgggcatgt aagtgaccaa 24540 attgctttcc cagctaaaga caatttcgtg aatccttccc gttctgaaaa cattaactag 24600 tgaacaaatt aaatacatta tctttcattg atggtgattc taacagtcct ttgtttctaa 24660 actaattaaa gaataggtca ctcaatctgc aaattcacgg taatttaagt gatctaaact 24720 tattcataaa ctatttaaaa aattgaaaat gagttcttaa gataatgacc aatccgaaat 24780 tttaattgca atgcattcaa aaccatccag ctgcaatgat cactccaaaa tttgaattga 24840 ggcaggatga agaatttgtg tatttagatg tgcatactcc gtatataaag gtatggttct 24900 tattctaatc gagtaataac tcaccaaggc aggctaaaaa cgttgaaatt gatgctttta 24960 acaatgaagt gaacttttgc attgcacctt atttccttaa gtaagtcttt tctaaatccc 25020 ataagtattt gggctatcta aatatttctt attaaaattg aagcagtgtt tactaacttt 25080 ttcccaaaga ctagaactgc ctggtaacgt tttagatgat gatcgggcta acgcttcata 25140 cgatatttca agtggttttg tgcatattaa atttcccaag gagactcctg gagaagtatt 25200 tccagacttg gatttactaa ctactttact tgtaaaccaa aacaaagaac ctgtcaaaaa 25260 gcccttaatc gaggaagtgg aagatacccc atcaccttca acttcgcaaa atgccagcaa 25320 ggatgaagaa aaagaggtta aaattgactg gcagaatatt catttcgatg atcccgattt 25380 cgattggggc ctgttgcaac ggttagatga tgaaaaggtt tgtttcttgc gcgacttgtc 25440 gacattctaa ctttatcatt agatgcagta cacatctacg tctcaatacg gtttcaataa 25500 tcagtattca ggactgctga agtataatgc tttggttgga aatgaaatta atcaaattcc 25560 tgaaccagag cgaactcctc cttctacgag aagtgaaata cgtgtacagc tagaagatga 25620 aaaatttgat gctgaacatt atatggcaga tttttatgac agggagatga tcgatgaaat 25680 attgcattat attcctgatt atattgggga atttttgctg gtccaacaag gcaaatccga 25740 cagactttta gaatttacaa gcgaagaaaa agaagcttta gccaaattac caaagcgaag 25800 ctaccttatt gacaatccga agaatgttta tctttgttta gttcctttga tttttgcata 25860 cgcatacgac aataggacta ctttgggtga tccaactatt gaatcatgtt ggaatatcgg 25920 aacactttca tccacgatat cttgtctcga tacaaatttc cttgcaatca aagatatatt 25980 tattgcatgt attagacgtt cgttggcata ccctttgtat agaaattggg accttgccct 26040 cacttgttgg aaagacaccc atgcgatttt gagccttgga aagcgttgga tattgagagt 26100 tttacttcgt attcgaaacc tttttgaaca tcacgatgtc tattatatat acaacgctat 26160 agtactaaac gattatgctt attggataca gacagcaaag taagtaaact gaaattcata 26220 ttttttctaa agactcacca ataattttag tgataatgtg ctagctgcat tagcctatca 26280 agtctcagaa tgtacaatta caaaagagga aacaaattgg ccgctggaag aaatcgaagc 26340 aaatgtacaa gaaacaatta ttgcttctga cgaggaaagc gagtccatag agaaataaaa 26400 gaaaaatatg ataccacaaa taaggaaaag gaatgaaatg acgacaggtc caggtattta 26460 ataagagtca tttacaattt ttggatggac acgaataaac ttttcggtgt tatttctata 26520 tttaaagatt aaaccataag gcattaaatc gacaggatac taggtattcc ggtattggta 26580 gaaaaaggat aaaaattaat gaagttgggt gaaaaataca ggcggcatag ttttcggtat 26640 gtcaaaagat ttgtacagac ttgtaaaaaa agaaaagagg attgcatgtt tttttgcact 26700 caagtaacga gcacccaaag aaggaaaaat ataatcacta taccgaaaat tttgaaaagt 26760 agtgctcgat ttgaagacat ccgttcataa aacttgacaa tctctctctg ggcacttcca 26820 atatttgaga cgatatcatc tgtatgcatg tcaatccgtt gtacggtttc acgttgctca 26880 gagaccatct gtgctaattg cgaaaaaata ccacccaact cggtaatagt actttcgatg 26940 ttttgtatag aagacatacg ctgctgggaa tacgtatcag tctggctttc aagtaaggcc 27000 atttgctcat aacgagtgtt agcaccatcc ccgagattca aggataaata gtcttcatta 27060 gcttcaggtt taggatcatt gtaatcagca aatggtgaaa tcgagtttcc agaatttata 27120 agggggttag cattcatgga actcgaggca acaaattttt ctgtgcggtt ctgggatgct 27180 ttcatgtttt gtgtccgaat ttcgagaatg tctttaaagg tcatactggt gtttgcgaga 27240 gaattttgca aagaaacgac aacgttctcg ctatgttgat tcatttgggc aggtttgtta 27300 cgatttcctt taacaacctg ctgtagtgaa gctatatccg aatttaaaga cgataagctt 27360 tgcttaattt gaaatgttag ttcttgaatt tctactggcc gatcgtcaaa caaagtcttc 27420 ctttttgcaa ctaaagaaat gttagccata cttaaccatt tgatttgaaa agacttaggc 27480 aacgttcgtt tgtgactatg cccaataagc taaatactta cgttgtgata gcttttgtaa 27540 cttttcgcca gtttgattaa tttggttagc aattttttgg gctatccttg taaattcgct 27600 cttttggtgc ttggtttgat cgggaccacc tactgcttga tttgcagtcg ttgtcctcaa 27660 acgagatcga gttttcgtga cacatgcttg aaattcagca gtcctatctt gaaatgacat 27720 gaatatttag tcttaaggtc ctcaagttga gtactttata gaaattgatg tgtggtgtgg 27780 agataggtag ctggtttata gcaagggttg gcaatataat gcataggacg aaatatcgtc 27840 cagtaaagaa agaaacttga gaatctagtt tttttattca aatattattt tgtagttact 27900 ttttagtttc tatctaaatt ttggcctaaa tcacactaca ttgtgaatag aaacctaggg 27960 tgtagactaa cgaaactttg atcgttttta agaaatatat ctatacgtta gagtaaagat 28020 ccttttaagt aagcaatggg tatttaatta aaccaaaaca aatggctttt gggttgttat 28080 gccacctcgc ttttgcagcc attgatcatg atctatctct atttcattga agctgagttt 28140 gagtatttct catttaataa tagacatact agtaacaatt cattccacaa cctccaaggt 28200 agaaaccaaa agttaaattc actacaagat gcactagcta aaagttatga gagaatgctt 28260 gaaaaagagt gcacaaagct gctctcaaat atcatttagc aatctttaac cagcttaatt 28320 cgttttatgt caagcattgc tcatgcgaaa ataaatagaa aaaattctta cttgagattt 28380 tgtaaatcac gcataaaaaa gacggaagct gttaaagaag agaagcatta ttttcaaaaa 28440 aagtttcaaa tatactcata tgtgtctcta aaattaaaag gttacataga aaatctgtct 28500 aggcctgttt ttacagggct ttcataaatg agtaaatcga agtcgaaatc aaagtgacct 28560 tgcagaaaca tactatacat attcataata ggaagctaaa gttttgaaaa tcactcaaaa 28620 aataggagaa tccctatgac gagaaattta ccatagtacg tgagaccaca aaattttgag 28680 agtttatttg aaaaaaatat tcaattatat ctttacttta cgcttgtagt ttggctgatt 28740 agtgtccaaa actatggtaa acagcttggt ttaatgtttt gaattttctt acaattgtcc 28800 acaaactgag tcgtattcaa caaaaaaaac gaaacttcga attatgaagg agactgttta 28860 ataggtaaaa taacgtttaa aacatctgtt ttctattgat gggctaacac ggataatagg 28920 tagtagtaag gttagtactt tatatccaat cccatactgt ctaatagtcc ttacttcctc 28980 tacacagcaa tgttgaaaat aggtcgaaat gctacgatat taaaaaacaa tttttgggtg 29040 agttttcttt tatttatagt tttattaata tagcatagtt tgcctccgtg aggtttcaat 29100 ctggagggtt ttcagaaaag ttggcgaaag gaccatcatt tgcagatttc ttgaacatgg 29160 ataaaccatt gactgctgac gaagctttcg agttagatag aaaagtagag ctaccaaatg 29220 gctctataca caaaagattg ccttcatggc ttaaaaccaa agttccacta ggaacaaatt 29280 ttaaccgaat aaagcatgat ttgcggggat ctcatctcca tacggtttgt gaagaagcga 29340 aatgtccgaa tattggagaa tgctggggag gtaaagacaa atctcgtgcc acagctacga 29400 tcatgcttat gggtgatact tgtactcgtg gatgtcgctt ttgttcggta aagaccagtc 29460 gccgtccagg tcctttagat cccaacgagc ctgaaaatac agcagaagcc atcaaacaat 29520 ggaaccttgg gtacattgtt ctcactagtg tcgatagaga tgacctgact gaccttggtg 29580 ccaatcatat agcaaaaacg attcaaaaaa ttaaagaaaa agccccgcac atcttggtag 29640 aagctttgac ccccgatttt agtggaagaa tggatttggt tgagattgta gctaaatctg 29700 gtttggacgt ctttgcacac aatgtagaaa cggtagagga acttacccca tttgttcgag 29760 atcgacgagc cacatatcga caaagtctga gcgtgctaaa acatgtgaag aaaacatgtc 29820 ctcaccttat cactaaaacc agtattatgc ttggtctagg tgaaaccgat gcggaaattc 29880 taacaactct taaggatctc ctggaacata atgtagatgt cgttaccttt ggtcaatata 29940 tgagacctac caaacgacac ctaaaagtgc aagagtatgt acatcctaag aagtttgaat 30000 attggaaaga agtggcagag aaattaggat tcttatacgt ggctagtggt ccacttgttc 30060 gtagtagcta taaggctggc gaatatttta tggagaatct tattaaaaag agatcaggaa 30120 accctgcttc tatgagtgtt taaacatggc tgcttatcta ggtacactcg ataggagttt 30180 gtcttcaaca gaattaccct tttttgcatt gactcgaatc atcttttaaa tttttttatt 30240 ctttatttca acaatacact cttagatata attttaatca taataattct cgtcttagtt 30300 tctaatatcg tctttatacc caagttatcc ttataattta tcatattcaa aattgatttt 30360 gttttccttg attagcgaga cagctttata atatttaagt aagaaaaaga cagcttcacc 30420 tttgtaagta tttaggcttt atcgtcgtcc atgcatcagc aacatatctg acaaacgggt 30480 catggccgcc aaaagtatct cttcaggaat gggatcattt agaaaagaaa ctgggaatgg 30540 gttaaaagaa atacttttgg cagtggagtc tacgagctct ttttgtacga cattgtcttg 30600 taaaacaaga acagcatgcc gaaacgaact tggtaaactc gcttctaact cttttgaagt 30660 aatagctgaa gtctgactgt tgatttgaac aacaaagtca tatccacctt tgtaaggaga 30720 acttttacac agctgagaag aaagacatga ccgcaccttg taaccccaat aatgaccacc 30780 tttttctcgt ggagctgaaa aagacacgat atcaccttga agctggcctt cttcgtttgg 30840 agactgcgct tttaatcgaa ccgtgaccct tgttctagga gcaaggacgc tggggctgga 30900 aacgattaca ttgtgagata gtccagcatt tataatatat ttattctttg cttgcggaga 30960 tggatgagta acgattccct ctcggtatgg gaattcaata ttcactgtgc tagccttgtc 31020 atttctgagg ggaagtaatg gaaagcagct agtatatttt agatgtggat ttagtggaaa 31080 caattccttc ctcataaaga aaggcgtttc gaaatagcat aataagtccg tgagaaattt 31140 tgtgggatcc tttaaataag catcagagga aagtgtatgt acctgggtgt tttgcacata 31200 ttcagggtcc tctagcaaaa taatttcgtc aataccatat agagaaacta ttctcgaaat 31260 ctatattttg agttaatacg cgacaacaac gaatctttca aaccttccag acaaaactcg 31320 ttttaagctg caaattgtat gctacattta gacttgaaat aggtaatgct aaagatatcg 31380 tatatcgtct cgttggtggt aagctttgta tttcgctttc tttttccata gcagtttctg 31440 taagcaatta atgagaagta ataatatggc ccaagtagca gtattttatt tactttttgc 31500 tgtcttggga aacagaatat taggatttgg ctttttataa aaattttaac gtcttaaaaa 31560 gttggtgaag agtaaaggca tgaatttcat ttaccaggct aaaaaccgtc catttaatat 31620 aattaaacta attttaaatt ttttttgaag tattgatcaa ggtaaaggga tattttatat 31680 caatactttt attgataggt aaaaaaaaaa atcctgtact tcataaacaa tgaaaaaaat 31740 tcaaacaaac aaatgtgttt aatgccattc aatgagtgcg atttaaacta tcaatgagtc 31800 ttcgtaaata ccaaagggct atagaatccc cttttttttt tttttttttt ttctttatat 31860 ggaaataata aaaaaaatgg tgtacacttt gcttgcaatt tatataaacc aactatacac 31920 gccgaagctt gtatataacc gctgtaaaaa tttgttagta gaaaaaacaa gatgatattt 31980 tattaattac atacataatt ttttaagtca atagaagttc atcgactctg attcaattca 32040 tcttcaatct tactctattt actatttact tttatgattt tcgctatata atgagtagca 32100 ccgggtataa cgctataaca gtttaaagta taatttcaat atcactaaaa aaatctaaaa 32160 acacgttaga gtacgttagg taggatgcat cgtacacgtt aatcaaaatc cttcgaatgt 32220 cgaacacgca gactacaaat acagccaagt tgctgccaat tataaaagca acgtttctct 32280 gctcttagta cgtggttggg tggatcctga tttctgtaaa aatcatattc aatatcaata 32340 accagtccat cttgactcgt agtctttgaa acggtgtaaa aggattgttg tcaggataag 32400 ctataatcta ttgttgttta aattgtagaa tcttcctctt ttttaaatat cgccgatata 32460 gcttgacaaa aaggctcatt ttgaaagcta ggcgttgtgt tctcgcaagg tttctttcat 32520 tatccggttt ttcgtatttc ttagtgaaaa cgccctctgt aacatcttta ctgttttaat 32580 tttcggatat actcgcgtat atatcgttgg atcatttatt tgcatttaaa aaagggccat 32640 atatattcca ttttctttac gacccagatc tttatacctt tttttctctt ctctatttat 32700 accttctcga tttacagata ttctcttacc ttcttttcta cattatttgc acatttaaaa 32760 aacccctaag gtttattctt ttaaaccgtt atcttgttcc atagacgcgc ataaccaact 32820 cattttttct cgcaaactgt ttgttttgca cttttttact ttgtattctg caagatgttc 32880 aactttcgtt tattttctcg tagaggaaaa agtttaggtc tcttggccat cgttttattg 32940 ctttttggct tttattcttt aaagtcttca atgcctgttt attccaattc gattggttct 33000 cccagtgccc attcctcttc atacaaaggt gtttctaagg cgaaaacatc tccacaagat 33060 cctgattccg tagtcatgtt gattgttagt tttgacgacc attatgattc aagtagatct 33120 gactccagct ctgtcttcct ggataaagtg ctttctgatc gtacagagta tgccttgcgt 33180 catggctata ccctagtcca caagaaagcc cgcgatattc aagcgaggta tggtgtctat 33240 ggtacttgga gtattatccc agctttgagg gaaactttgg ctgagtatcc cgacgctggc 33300 tggatatggt tgctcgatgc aaaggctgtt ataatgaatc cttccgaatc tctcaaggat 33360 agggtcttga aaccagaaaa actgtcgcag catttgcttc ttaattctcc gatcgatcca 33420 ttaaagaact acatccgtac acgccgtaaa atggatccat ctgatgtatt tgtaattacc 33480 accagtgatt ataatggaat tagtacgcgt tctttgctta ttaaaaataa caactttgcg 33540 ccatttcttt tagatgcttg gaatgaacct ttgttgaaat ccgccggttt tgatcaagct 33600 gagcgatctg cgctatccca cttattggaa gcacataaca ctatcttgga tcatgttgca 33660 cttgtgtctc ctaaagtttt aaattcatac accaactctg cggtcgattt gaattacgaa 33720 gaaggtgatt tcttggttat tcttcaggac tgtgagaacg ctgctgcatg cgagcgtata 33780 ttcgagtatg tattctattt atcatcttgg tctcttgtat ttttactaac acttccagca 33840 actactatca acagagaaaa cttccagcca ttaaaaagca gctttcggaa gaaacggttg 33900 atgaacaatc gtaggttagt actgtcttag catcttactt tcatttccag taactcatct 33960 tcatctaaac ctatctttca aattcggtgg tttgcatatt cctacattaa tttaatgaat 34020 ttatacttaa tttcctttgt ttgatcaagg gaagatatgt ttttcgttta cggaaataca 34080 tcgcagattg gtttacaagt caagcaattc atatgttata ttcatcaaat cttcttaatg 34140 aaagcacgtt aattgctatt ctatgcaaag aaagaaacat ttattatgtt tgacctgaaa 34200 tccacataaa cccagttgaa taacattaat gcatttcatg gcgacataga gacatagatg 34260 ctgttgaaac atcactcatg caaaaaaaag aggctgaaac atttttaaag taattataac 34320 ttcaaaataa attctataaa ctaaatgata agaatagatt agtaacgata gtgatcagcc 34380 ttgtaaggac cgtcaacagg gatacccaag tagtcggatt gaacagaagt caaagtagta 34440 agtttgacac cgagtttacc caaatgaaga cgggcaacct cctcatccaa cttcttggga 34500 agcatatgaa caccaagagg atagctggtg ttatcggtcc acaaagcgat ttgggcaagg 34560 acctggttag tgaaagagca ggacataaca aaagagggat gtccggtggc acaaccaagg 34620 ttaacgagac gaccatcagc taaaagaatg atatgacgac cgttcttcaa ttcataacga 34680 tcaacctggg gcttgatgtt aacaacatcc ttagcgttag ccttcaacca agcgacatcg 34740 atctcgacat caaaatgacc aatgttacaa acgatagagt cctccttcat ttcgttgaag 34800 tgctcaccac gaataatgtc acggcaacca gtggtggtaa caaagatttg accttcctta 34860 acagcctctt ccatagtggt gacttcgaaa ccgtccatag cggcttgaag ggcattgatg 34920 ggatcgactt cagtgacaat gacacgggca ccttggctac gaagagaagt tgaacaacct 34980 ttaccaacat caccaaaacc agcaacaaca gcaactttac cagcaatcat aacatcagtg 35040 gcacgcttga taccatccac caaggactcc ttgcatccaa aaagattgtc aaacttggac 35100 ttggtaacag agtcgttaac gttaatagca ggaaccttaa gcttgttctc cttgaacatt 35160 ttgtacaagt tgtgaacacc agtggtggtc tcctcagaga taccacgaat gtcaaccaaa 35220 agttcagggt gacgctcatg aacaagagca gtcaaatctc caccatcatc caaaatcatg 35280 ttcaaaggct taccactagg gaaagacttc aattgttgct caatacacca gaggtattct 35340 tcctcagtct cacccttcca ggcgaaaaca gggacaccag tggcggcaat ggcagcagca 35400 gcatgatctt gagtagaata aatgttgcaa gaggaccagg taacttcagc acccaaagca 35460 accaaagttt cgatgaggac ggcggtttgg atggtcatgt gaaggcaacc agcaatacgg 35520 gctcccttca aaggctgaga cttggcatat ttctcgcgaa cagcgatcaa accgggcatc 35580 tcattttcag cgatttcgag ctccttgcga ccaaaggcag caagagagat atcagcaact 35640 ttgtagtttt gagtagccat aatgagttaa aaaattatat gattctatta aaaatagtaa 35700 aaaaaaatag atgtatcaag caaaagatca actaccacgt ccttacgaat ggttggcaaa 35760 ggatgagttg aagtgcgaaa aaatgagtcg actaagcaca gtaagcctct taatcaaatt 35820 tgttgagaaa aaagttttat taaataaaaa atattcaata aaaacttttc ataaaaaaat 35880 attcctccaa aacgaagttt acgagatgac gatcgatctg caatgggaaa atgtttgaaa 35940 ttcaggtaat tcacttaaaa acatatattt attgtaattc ttgaagttta atctaaagat 36000 ctactcattc taagctcttt agcaggagct tggtgagtaa atgcagccaa gcgcgtaata 36060 tgttggaatg taaacaaaca taaacaaacc cattctcagc ttctatttct accactatac 36120 atattttact gaaaacacag atacaatgag taatgaaagt atttactcag tgttagattt 36180 gacacaagtc atatttgaag atagatattt ggttaagcaa aagctcggtg atggcagctt 36240 tggaacggta tatttagctc aaagaaaaga aaaaaacgga ctttacgaaa cagtaagaaa 36300 agaataaaac aaacttctga aatctaacaa ttgtgaaggt tgcggtgaag aaattaaaga 36360 acagtagcaa gcccaaacca aagcatgaac ttttgaagct gagagaatcc ttggtaagta 36420 cttaaaatct tagaagaaga aaccaaagat gtttcaacgt cgttcagctc aagctcgaca 36480 aaattgaatt actgtgttta tcgcatgcat tttttaaatc ctattatcta cgagtctaac 36540 aaaaaggcat tacgaaaaat ttcaaagcat ccttgtttaa tcgatctctt ggagacgttt 36600 atggacccct atcgcaatat atttttagtt atggagttta tggattgcaa tctattccag 36660 ctttttaaaa ggcggcaagg aagacttttc acaaaggaaa cagcatttaa tatacttctg 36720 caaataatca gtggaatcga gcatattcac aagcatggat tcatgcatcg agatatcaaa 36780 cctgaaaata ttcttgtcaa aaggatcagt cccaagccca tttcgtcaag gtactccata 36840 aaacttggag attttggctt agcgcgtcca tctgtttcaa gtgacccatt gactgagtat 36900 gtatcgacgc gttggtatcg ggctcccgag ctattgttac gaagtggatc atataaccat 36960 tctgtagatc tttatgcatt tggatgcatt gttttcgaga tttactcttt aaaacctctc 37020 ttccctggta ggaatgagac cgaccaactc aatcgcgtct gcgaaatttt gggcaatcca 37080 ggaattgatg aattagatac actacattat tggtctcaag cgaaagaatt agcaaagaga 37140 ctgggattta tgcttcctcc aacaaaacca tatcccatcc agaagttgct tccgcaaaat 37200 tgtccagaag gtcatgcaaa gatgattcct tgtttgttag cttggaaccc cgatgtacgg 37260 ccaacagcca aatattgtaa agaggtgttc tttcctttac ctccaagtgc atcaaagtca 37320 aattctgttc cacagaaaat cagcaatccc aaggtagagc aaaatttggg atttccaatt 37380 tcaagggagg ataagaaatc aacaagaaga gtgggttggc taaaaaaaaa tctatccgaa 37440 tttgtgagtt cggtgaaaag tgtatttcct gattcgcatg gttctcaacc gcacgtaaaa 37500 accgaaaagc cgattaatgc taaggaatcc accggacatc ttgcgaaccc tatagcttca 37560 agtaatgtcc cagccatctc gctgaagcca ggtgagcttc atgaatcggt attctttagc 37620 gagaacgaac agatcgatta tttattaact tcgattgatt acctcccatc gtataaaccg 37680 ccttctaatg gaagtaacat tgcgataaac gcttttaatg agactgttgg cgacagaatt 37740 ccttcgtcta aagacatatt gataacggag aaaataccgt ttaaaaaaga aaacgaaata 37800 cgagattcca ttgttccttc atgttcacaa cctgatgaat ccaataagga aggtgtcgcg 37860 tcatgcttac tactccagaa aagtgggatg gaaatgactt cagttttaga atactcaact 37920 cctaatcctg ctgaagttca aaacatatgt aatgaccatg caaaattcga aaccagtaaa 37980 agcttacatc taagttcgcc atgagtgaaa gtaaaatgca aatgaagaga aacttggaca 38040 ctaattattt tatcggcatt catgtttcca tctgaagtta tttcaagaat tcatcgacta 38100 tctcatctca tccgaatcaa ctttaccgat taacaggact ctggataagc ttgtatttaa 38160 cattacccgc ataaaacctt ttaaacaacg gggattctta ctaagtactt aaaaacaaat 38220 atggaaatta atgtcaacgt aatgtgctat tcggcgaact attttcatca agcctctaaa 38280 tgtttaggga tcaaagagtc tacaaaagaa gttgcagttt catgaaattc gccagtttca 38340 tgctatcaca acttaaagtg taccaggctg caaacggtaa agtcatgtca taaacatcaa 38400 caatataaat atagatcctt cacaaaacta tttcccttca ccttccttag ctacatgagg 38460 ctaaatagct aaacatcaaa ctaatatcaa atgcctaata cttaaaaacg taattttgat 38520 ttcgtttagg tagtagactt actcaaagtg ataagtctgg taacaccaac gatccaatgt 38580 tcacactgat caccaagtgt agtaacgatg ttagtttgaa tattcgacgc agtttgataa 38640 tcatgagcat tcaaagaagt agcaagggcg agtaattcgt cagtcaaagg ttttgataaa 38700 acattagagt taaggcgatc aaacagcatg tttaatcgct tttcagtatc atggactaca 38760 cgagacattt gagggggtag agactgggat acacgctgca gttcagcatt taacatctcg 38820 taaataggtc tcaagttacc aggaatatga ctacgatctc cagcaggata tgtcaatggt 38880 gcactagttg atgcagcggt agaagaacgg cctgcagacg ttgcaattgg aggtcgtgaa 38940 actgctgaag agcttggaag cgcagtactg acaggaggtg gttgaggaat ttgaggtctt 39000 gtagcagaaa ctgggggtaa acggctggaa acgggaggga gttgaggtgt cacggaggga 39060 gaaagagcgg atggggaagg aacgctgacg gttgggggct cataagcaga agctctctga 39120 gaagctgtgg gtggtaaagg caccactcgg ttagcgggtt gtttaggagg tggaactatc 39180 tgagatccgc catgaggctt gtacgtatga gcagggttaa cagttgaaga agccactgca 39240 attggtgtat aagggtttga gggaggcatg tttggagagg aagaaatacg agaagcagca 39300 gcaacaggtg actggggtgc tacaggtgta taaggatttg gatgactggg ttgttgcact 39360 ggaggaacac gcgtaccact tgccgtagga gggtggtaag tctcaccgac cttaggagga 39420 ggtggtgatg ctatagcggg agcgcttgca gtcatggatg cagtaggagg aggaggagga 39480 agggtgctaa cgctgctagt acgggacatt gcagctggtt gagcacttga agcaccaggg 39540 aatgggcttc ttaccggggc catagaagga gcagcacgtc tcataggtag ctgaccaagc 39600 atgggggcat cattccatcc agcagtggta gacgtactgg gaggaggaag tgggtggaca 39660 tcagcaggcg ttatgtggga tgatgttgta gcataaggcg aagtatatga agtcgttcgt 39720 ggcaccgttg gaagtatgga ggacgcttga gaagttttgg gttgtacagg cgcatatcca 39780 gtttgcttaa tttgatggat aggagggact gcatggggct caagcaacat ggtcaatctt 39840 tgaatttctt cttttgcgcc agggaactct gtaggtacaa gattaagata gctcatagca 39900 tcatcaaatt ttcctgaagc actcaagatt ttagcgtatg caatataaac ctcataaaga 39960 ccagccaact tccaatcttt cgttgccgaa agctcatcat ctttgtagac aacgatggag 40020 cggaacatgc taactttatc catcagttta gtaagttgtt ccacataagc accatatgcc 40080 gaagctgcct tagatgtctt agttgaagta gctagctgct tcaaccaaag gttagcataa 40140 ctctgtaatg atttgctagc aatataacaa aattcagcag atctgataga tttctcatct 40200 tcgaggtctt caagacgctg tcccaaagta ctgcacaatg gagcgaactc atcatcggtt 40260 gcataggtac aaataaacac aaaaatgtcc ttccattcac taacctctgc gttatctaca 40320 acattttgta aatcgttatc agcaatacat gcagatagac gcatgtatga aggtttgtgt 40380 tcttgaagtt cataaaacgc gtctcttacg catttacgac attccttacc accaaaggtg 40440 gataagaaaa gtgcttcaga tatttttttc tcctcaaggc aagctttcac ggccgataaa 40500 acatcaccgg taagaagcgc ctcagtgatg tttttctcta agtcagaatc ttctggattg 40560 aagatcttaa atgaatcttt tacaatctca gcatccttct tgtcagctat agatacttct 40620 tgcacacttt cggctaattt cccataaaaa gaggaatcat catcataatt ctcattatta 40680 gcattctttg aaagttcatt aggtgttgtt gaatccttgg caacagactc gtctaccttg 40740 ctgtcatcct catcgttttt tggttttaat gtcttataac ccaaaagttc agcaaactta 40800 gacctagaag cgcgcttact gacggccata agtagcttcc aatttatggc ctcctcttcg 40860 gaggcggatt cttccacacc tttctgacaa aaatcagtaa tttccttttc agtttgaaat 40920 ttggcggaag aatggaagga cttagcttca tcttgctcaa cttcatcggg agcagaggtt 40980 atagtgacct ctttagaatt tggcgaaaaa ctaacgatct tgttggggaa gccaaatcga 41040 gcaccaacag gtactttaaa ccacttggga gcaagaggta gtgaaaacga aggttcttgt 41100 gatccagcaa tggagggcaa attgttaaaa aattcgttat catctatgga ggtagcacct 41160 ttaatagagg cttcttgact cttgtcggtg tttgtgcttt gaattgaaaa gatagatacc 41220 ttaccctcca aagaagcgac agcaacacga ttggaattag aaggacacca agagcttttt 41280 gtataccaat taccagaacg aggaaaactg cccaaagatt cgccagtttc aacattccaa 41340 accatagcac gcccatcctt tccactactt agcaaaaacg ttggatcttc agggcaccac 41400 gaaagagaga gtgcagcctt ttggtgtccg gtaaggatgt tttgaggaac agtaggttgg 41460 cgtaaatccc acgttaggat gatggggttt ctattatcat caatagcagt tgcaaggcga 41520 gtggcattat tagggtgcca agcaatactg ttaaccgctc cggtagctgc gctaacaccg 41580 gcggcaccca aatatgatag attcaagact tggcgtttaa gcttaacgtc ccaaacggta 41640 gtgtattcag tagcgttacc agaagctaag atatgtgaaa ctttgttatt ccaagaaacc 41700 acatgaactt cggaggagcg attttgtttt gggagagcga aaggctgttg tggatgcttg 41760 atatcccaaa cccaaacatc acctttatta tcaccagagg ctaaaagatt gggttgtaat 41820 ctattgaaat caagagggcc gagaatcgag ccgttttcgg atttataggt agcaattgaa 41880 gcggacgctt catctgattt caaaatagca gcaggatccc aaaatccaat accgccatct 41940 tctaaactac cagcgattac acccatgggc ttatctaacg atttctccca tgctaaatcg 42000 taaaatctag tcttcacgtc gatagatcca acgggttttt gtgattcagg attttcattc 42060 cacaattcaa gcaaggtgtc gctgttttta gaaccctccg tcccggtata tcctcctaac 42120 gctaacagag cttggttatc attcaccccg cggggcgacc acgccaacgt agccgttttg 42180 cttatatcct tcagtctcat aactcacacc aacttgtgaa atattgtaaa aactcctttt 42240 tatcctgttt caactatagt ataacaggcg agctaacccg ttttttgttt ggtatgatgt 42300 gtgggctctt aaagtggttg gttcttagta gtttctttta atacatatag tccacatgtg 42360 gtagtagtag gctaaagggt agcataggta acaaaggata atacacatag tgcagtacat 42420 aaagctttct ttggaactca gtggtaaatt ctcactaaaa gtaaaaaaaa aatagatgga 42480 caatattatt attattacga aaatgaagga aacccttgat tgatgcttat atacaagaat 42540 tcatagatac cctgttttgg tggaaattta catagtcagt caaattttta aataggatga 42600 cccaagaagg taaacacttt aagtgcgcag tataaaggaa caaaaactcg gaagaccagc 42660 gtattcccag catggtccgt acacaaaaaa aaccagtaag gaaaaaatta aaagaatact 42720 tttttgtagg ttgaattgaa tataagaagt aaattttgaa taagatttcg aatttgcacc 42780 aatacccttg gaaacgtagg agaaatgaat tagaaagaac ggagcttggg tggagaaaag 42840 gaatccaaag taccaaagca aaattgtcgt cctgtaaaag aagtattaag acatgggcat 42900 gagacaaaac gaagccaaaa taagcagaat gatacgactt gaaagttgtt acattttctc 42960 ataaattaga gaacaaaata aagcggaata ccgcattgtg tcagtcagca acaagcacaa 43020 gggacgtatt attgtttaat ttttcctttt tcttatttca tttgaatgtt cttcaggaag 43080 gaaacgctga cacgggtttc atcgaaagcc tatttggaag catttgtttc gggtgaaaat 43140 tgttgttgct gcatttgttc taactgttgt tgctgaacct cttctggatg gaagagaaga 43200 ttaaagatgc ttgttttttg ttcagcctct cgagcctttt cttcttcaag cattttaggt 43260 ccattttcgt caatatactt tttaaattca gcataagcag ccttttgtcg ctcacgctgt 43320 atatcaatga ttaatttggg tggctcttca gatacactcc gtcctccaaa caaaaaggaa 43380 ctgcctttct tcttcttctc attccaatct tcaattaact tggtgcgtag tttttcctct 43440 ctgcgggcat actcaagggg aatgttttta ccttgataac ttttaagaac tggacgaacg 43500 tctttaatat ccatgatagc aataaactcc aaaagaggaa ttaatccgac caattcctta 43560 tccttaggat ttcctgtcca tggagccatg gcaattgcgt tatcaggctg tttggaccat 43620 gactcgggat tcgtatcgat catgatcact cgagacaggt cacgattcaa gtaagataaa 43680 tctttgataa ccttaccctt ctcatatttg cttgactcgc gagtaagtac ggcactaata 43740 cttacgtggt atggatc 43757 //