ID SPBC609 standard; DNA; FUN; 15301 BP. XX AC AL035226; XX SV AL035226.1 XX DT 15-JAN-1999 (Rel. 58, Created) DT 24-FEB-2000 (Rel. 62, Last updated, Version 3) XX DE S.pombe chromosome II cosmid c609. XX KW 5S rRNA gene; guanine nucleotide binding protein beta subunit; KW major facilitator superfamily protein; KW possible chromatin-associated HMG protein; protein phosphatase; KW protein-tyrosine phosphatase; SSRP; structure specific regognition protein; KW trp-asp repeat; WD domain. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-15301 RA Seeger K., Harris D., Wood V., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (11-JAN-1999) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; O94525; O94525. DR GOA; O94526; O94526. DR GOA; O94528; O94528. DR GOA; O94529; O94529. DR SPTREMBL; O94525; O94525. DR SPTREMBL; O94526; O94526. DR SPTREMBL; O94527; O94527. DR SPTREMBL; O94529; O94529. DR SWISS-PROT; O94528; YBU4_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c609 Is overlapped at the 5' by cosmid SPBC405, EM:AL035655 CC and at the 3' end by cosmid SPBC776, EM:AL035263. XX FH Key Location/Qualifiers FH FT source 1..15301 FT /chromosome="II" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c609" FT /map="IIR" FT misc_feature 1..99 FT /note="nominal overlap with cosmid SPBC405, EM:AL035655 S. FT pombe chromosome 2" FT CDS join(742..862,1005..4357) FT /db_xref="GOA:O94525" FT /db_xref="SPTREMBL:O94525" FT /label=SPBC609.01 FT /note="SPBC609.01, len:1157, SIMILARITY:Candida albicans, FT O13327, protein phosphatase ssd1 homolog, (1262 aa), fasta FT scores: opt: 711, E():0, (31.3% identity in 1155 aa)" FT /product="hypothetical protein; ribonuclease II (RNB) FT family" FT /gene="SPBC609.01" FT /protein_id="CAA22830.1" FT /translation="MDPHWKRHDSSNIPTQPSPSASPKSNKPSSAQRFGNLPWVAPDVI FT QSQIEYLQALQMQQSLSESENYLQPNFFPFQSGPFSKSRRENTLLPRLNPLAPIGARQP FT NPSIPQQFSKPINESGTGTMGPAVGELTSPVMKNRAESIFSPVTESFEAFTQGMQTTPQ FT RAGAGVSTATSHTRRRSSAGTDPFSPVSPSNPNFLTPLKPIDGNQEWQQSPLESPLSMH FT SLQESLHSVEPESPIFQQAPQIPLSNASQQSYINHSSDGASLPQSSFLNFNSSGKRVSV FT SAAAQQHKNLFLPYLPQASLPKFIGTGKLLVGTLHINRKNRSDAYVITDVLDEPIFICG FT SKDRNRTLEGDLVAVELLDVNEIMQTKREKEEKKIRRNLSLSGSSKYSVNSKAKMMSIS FT TPMALGMNRGVLSFERSIEKRKNDYEVTGQSLSFVDDVSLTPDSAPKYAGHVVAVLNRP FT SGETCSGTLALYRPNSLALKNQSSHRRNSSTSSGETGKGPKIVWFKPSDKRIPLIAISS FT DQVPPTFFTNNDDFKDKVFLAGIKRWPTTSLHPFGTLYESIGTIGDPKVEYKAILHDFS FT CHTYDFPESLSHCVKRLPTPIPAEELQKRYNLRDKLTFMIGTRDYALHIDTGSIDGVIT FT LGIHVADVAYYVKQDMPLDDEAANRVSEVQLLQGSVPFLPKKVSEEISLIEGHDCLTIS FT IVVQLDLKSGAVLQCSLGPSVIHPSSFISLESAQANLQTNEALQLVDASAHVLTKLRLK FT TDKKLDLQSLYCFEFCDGQIPNIQNINMSIFEAFPIACSLQQIEHWVNEKVASHLMSVF FT PSKVILRKNQRPSDFASLVAVSELTGVNLSASSTPSEIMTEIATTKDKRTKMLLQLTLR FT RMCNESEYTIGTSNAKDVSHFVFSCPYYTHFCHPTRRYIDICVQRQLREAFDGRPDFSK FT DYRSLLSITQSCNTLSNFYRNAQEKSLHAYLCQLLHSINLRSGLVKHKAFVLAVDQEYI FT DIVIYEFGLERRISLDLLPLSNCDFNEQKHELYLSWRTNASFFYASSSLEIDTPCFNDF FT KKKFLDSNGMCKQICDMMDAQVRDLANAAESQESFYSKARGNDSTSKTAKSSSGNQDIS FT GDGKLHSLRMKEPEVVQTIRPGQEVSVLIFADTSATYSLSLITLQSPLSS" FT misc_feature 863..868 FT /note="gtaagt, splice donor sequence" FT misc_feature 988..1004 FT /note="ctaactcagttatttag, splice branch and acceptor" FT misc_feature 2459..3508 FT /note="Pfam match to entry PF00773 RNB, RNB-like proteins" FT misc_feature 2954..3013 FT /note="PS00389 ATP synthase delta (OSCP) subunit signature" FT CDS 4968..6014 FT /db_xref="GOA:O94526" FT /db_xref="SPTREMBL:O94526" FT /label=SPBC609.02 FT /note="SPBC609.02, len:348, SIMILARITY:Drosophila FT melanogaster, Q9Y0B6, pten1, (418 aa), fasta scores: opt: FT 413, E():5.3e-21, (30.7% identity in 358 aa)" FT /product="protein-tyrosine phosphatase" FT /gene="SPBC609.02" FT /protein_id="CAA22831.1" FT /translation="MNILRSVVSRGRKGLKQEKVNRSFAYLDMVYITSKVIAMSTPAAG FT IHKLYRNDELDVFKYLTTQLKDNWILLNLCAEETVYHLELFKPNVINYGFQDHNPPPLL FT FLWAIVMNMDALFQTQPLLTLVVHCKAGKGRTGTVICSYLVAFGGLTAKQSLELYTEKR FT MVRGHGLTISSQIRYVYYIEILKQFPNYLKAVEFNTGTTFFKSFKCLNIKKNSSLILSL FT HAFSKGRNINPVALWKSSDISSHNVSIKEGKRIWGIQCNLETSEKDLLLRVERKGQFYF FT PSSVQCWFHTHFQPMLVEYTNGINFQQGINSFLQGQQSISFSWSEMDNSRRSDPFFEQL FT TIVYENVF" FT misc_feature 5346..5384 FT /note="PS00383 Tyrosine specific protein phosphatases activ FT e site" FT CDS join(6317..6377,6423..6516,6563..7247,7289..8787, FT 8839..8929) FT /db_xref="SPTREMBL:O94527" FT /label=SPBC609.03 FT /note="SPBC609.03, len:809, SIMILARITY:Homo sapiens, FT CAB52430, dj703h14.1 protein, (485 aa), fasta scores: opt: FT 359, E():3.8e-15, (31.1% identity in 344 aa)" FT /product="putative guanine nucleotide binding protein beta FT subunit-like" FT /gene="SPBC609.03" FT /protein_id="CAA22832.1" FT /translation="MSGISLSLRQLDYRDWFQRKISRDIYGNSTWLTGIDLQKELTGHT FT GCVNTLDWSADGEFLLSGSDDTRLIVWDVFNEYKPRHLISTGHVQNIFSAKFVPYSNNR FT QILSASGDKLIKLFDLDSSKEGGMDHGMETQTRCWSCALDSVKNIVPCDNGHTFLVCSE FT DGTARQYDIREPHVCNQDLDCPSILVNYNPYRINLYTITMSPSNPYYFAIGGTHPYAFL FT YDRRMVKKSFRDDWTMNTSPEKDCRCVRKFSPDGSCNSQGILDRYITCCQFSAANPNEL FT LVSWNSDYVYLFHVHEDKSYTPTFNKIEDSNKKPSKPSLLQTQPLKRKNYSPWYKNNFG FT ASTPASRVSRNPYTAAQPRKHTFYQMYENIEKFFTTENGGLYESIVSGRLSHFSRSIQY FT VKDAIYFLENYNYIPDSNGLNHSIRVSALRYWRACVSILALMDDTVSLEPNTIIQAGWG FT WLYDFMNWVTRYLLGISDHWALQMSPPTNVARQNFVLCDPDEPSRVLFSNPSEMIRAFA FT RIDTNDLSSVRRFFWIHKVLRGCLLLISSDIYWEQFQPWDSSTSDVTSSQRLDDENGFL FT TLLEPPVNYENEVESSSGENIVSMYTGHSDLNDDDDDYQDEESYSYASDDDDESDEDSD FT EGPTLLSLRMKKRKAVEPNVPVNTHVKSYYGHCNVESIKNVNFYGQNDEYVMSGSDDGR FT FFIWDKLNASILAIIHGDSEAVNVIEGHPRCPTLAVSGIDSTVKIFNTENTPPSGCSRN FT HTSNSYKIIATNEMNRQQGSRDSYITSRMLSHLAYRAHLDDGFGHEVLDTDACSIM" FT misc_feature 6378..6383 FT /note="gtatgc, splice donor sequence" FT misc_feature 6407..6422 FT /note="ctaactagtttattag, splice branch and acceptor" FT misc_feature join(6464..6516,6563..6626) FT /note="Match to PF00400 WD40, WD domain, G-beta repeat FT Score 28.29" FT misc_feature 6517..6522 FT /note="gtaagt, splice donor sequence" FT misc_feature 6549..6562 FT /note="cttacaattttcag, splice branch and acceptor" FT misc_feature 6698..6829 FT /note="Pfam match to entry PF00400 WD40, WD domain, G-beta FT repeat, score 2.10, E-value 29" FT misc_feature 7248..7253 FT /note="gtaagt, splice donor sequence" FT misc_feature 7273..7288 FT /note="ctaatgtttgttatag, splice branch and acceptor" FT misc_feature 8288..8413 FT /note="Pfam match to entry PF00400 WD40, WD domain, G-beta FT repeat, score 8.20, E-value 4.6" FT misc_feature 8423..8539 FT /note="Pfam match to entry PF00400 WD40, WD domain, G-beta FT repeat, score 11.00, E-value 2" FT misc_feature 8788..8793 FT /note="gtttgt, splice donor sequence" FT misc_feature 8823..8838 FT /note="ctaaccgttcttctag, splice branch and acceptor" FT CDS 9825..11420 FT /db_xref="GOA:O94528" FT /db_xref="SWISS-PROT:O94528" FT /label=SPBC609.04 FT /note="SPBC609.04, len:531, SIMILARITY:Schizosaccharomyces FT pombe, YDFG_SCHPO, hypothetical 59.3 kd protein c17c9.16c FT in chromosome i., (531 aa), fasta scores: opt: 2862, E():0, FT (76.7% identity in 532 aa)" FT /product="major facilitator superfamily protein" FT /gene="SPBC609.04" FT /protein_id="CAA22833.1" FT /translation="MGFLRETVFGELVEYVSHNSNDNDLEKLRVWKDISKVDSNDSCSS FT ESGDLKIHEVNSEGHIIVRWDDANDPENPLNWPLWAKLVVTFDICFLTFAVYVGSAIFT FT PGISEMQETMHVGTVPVVLGLTLFVLGYAIGPLILSPLSEIPQVGRQKIYVLSLLVFVC FT LQIPTALGSSLGVLLPMRFLAGFFGSPALATGGATLADIWQPWLLPYFMCFWAIGAIGG FT PVLGPLLGGAMVVAESWRWQFWLLMMISGFALIVIFFFMPETSEWHILYKRAKRFRKIT FT GNENYRTEAELASSHLSVAQLAKETIIRPIILSISEPIVLSLNIYIGLIYSILYLWFEA FT FPILFTSVYHFTIIENGLVYLGILVGALITLACYFVFLYKVMIPAFMASGGDFAPEGVL FT VISFPATFFIPICLFWFGWSGRESVHWIVPIVSTLFYASGAFLMFQSMFQYLAASYPKY FT VASVFAGNDLFRSAMAASFPLFARAMFNNTGPSYAPVAWGSTILGIVACLMIPIPFVLH FT KWGLKLRSRSKYAS" FT LTR 12108..12331 FT /note="Tf2-type LTR" FT LTR 12204..12417 FT /note="partial Tf1-type LTR" FT CDS join(12554..12790,12850..14151) FT /db_xref="GOA:O94529" FT /db_xref="SPTREMBL:O94529" FT /label=SPBC609.05 FT /note="SPBC609.05, len:512, SIMILARITY:Vicia faba, O04235, FT transcription factor., (642 aa), fasta scores: opt: 1041, FT E():0, (34.8% identity in 511 aa)" FT /product="similar to yeast POB3 protein that binds to DNA FT polymerase I; putative structure specific recognition FT protein" FT /gene="SPBC609.05" FT /protein_id="CAA22834.1" FT /translation="MAAKTVQYDNIYLNLSEKPGKLRIAPSGLGWKSPSLAEPFTLPIS FT EIRRFCWSRFARGYELKIILKSKDPVSLDGFSQEDLDDLINVIKQNFDMGIEQKEFSIK FT GWNWGEANFLGSELVFDVNSRPAFEIPISAVTNTNLSGKNEVALEFSTTDDKQIPSAQV FT DELVEMRLYVPGTTAKEDAADGEEVEQNAANLFYESLKERADIGQAAGDAIVSFSEILL FT LTPRGRYDIDMYETCMRLRGKTYDYKVEYSSINSLFLLPKPDEQHVVFVIGLEPPLRQG FT QTRYPFLVTQFVRDEDMEVDLNIEETVLKEKYADKVKASYDQPAFEVVSQIFRGLTGRK FT VTTPAEFLSHEGHAAVKCSYKANEGQLYCLDKSFLFIPKPTLLMNTSDITRVTLSRVGM FT SVSAARTFDLTFTLRSGTSYQFSNINRVEQSALVAFLESKQIKIHNDLADETQQTLLTS FT ALDDEDEEGDEEMEEALSEDEDFQAESESDVAEEYDENAESSDEEGASGAEGSE" FT misc_feature 12791..12796 FT /note="ctgagc, splice donor sequence" FT misc_feature 12832..12849 FT /note="gtaaat, splice branch and acceptor" FT misc_feature complement(14711..14790) FT /note="SPRG5SD K00771 Yeast (s.pombe) 5s rrna gene and flan FT ks" FT misc_feature 15162..15301 FT /note="nominal overlap with cosmid SPBC776, EM:AL035263 S. FT pombe chromosome 2" XX SQ Sequence 15301 BP; 4486 A; 2800 C; 2852 G; 5163 T; 0 other; cgaaagctct ccatacactc cattcaacga gcattgtatt ttactccatc atctgttacc 60 gcatttgctt gcttctcttc actgcatatc aattggatca ttcctgctta cgatccacca 120 tatccattgc tttttctcct ttttttgtta tttcttacat ttttgtgttt tcatactcta 180 cattactaac ttcctctgtc atcgtcataa ttaccacctg tcatcgtctt tgctctttac 240 atactctaaa ccacctttct catctggata cgttgaaaca ccgtcatctt gtatgaggaa 300 aaagcagtac tatattggtt tcgtttgttg ctacaatctt tgggttttcg ctctgccaat 360 ctctcctaca ggaattgtcc ttgtactccc cagtgaatag gcgcacattc aaaagcatca 420 gcgtatcgag atactttttc acaatctcat actctctctc cttctttctt ctccattttt 480 ttgtttcttt gcattactgc gtccccacaa taattgacga ggactactgt aaccttcgtt 540 caaaccgttt cctctgatcg tttttgtttt ggttttcctt gaaatacttg caaatcgaat 600 agatttactt ttttgtctgg tctctgtttc actctctaca tattaaattt ccgtaaacat 660 ctttcttcgt ttaagacagt gtctttcaaa aaaaaatcaa caataacgat acggtcaact 720 catttcaact aataaaaaat aatggatcct cattggaaaa gacacgattc ttcaaacatt 780 cctacacagc cttcaccttc cgcctctccc aaatcaaata aaccttcctc tgctcagagg 840 tttggtaatc ttccttgggt tggtaagttt tgtcaagttc gatgaagtat cctgcaacta 900 tgaaataagt ttttctttga attttgaatt tttttttttc atcttgctag attcttcagc 960 ttttttcttc taccagagta tttatcacta actcagttat ttagctccag acgtaatcca 1020 atctcaaatc gagtatttac aggcactgca aatgcagcaa tctctctctg aatctgagaa 1080 ttacttacag ccaaactttt tccctttcca atccggtccg ttctcaaaat ctcgaaggga 1140 gaacacattg ttgcccagat taaacccgct tgcacctatt ggagcaagac agcctaatcc 1200 ttcaattcca cagcaatttt ccaagcctat caatgaatct ggtactggta caatgggtcc 1260 tgcagtagga gagctcacca gccctgtgat gaagaatcga gcggaatcga tattcagtcc 1320 ggtaactgag tcttttgaag catttactca agggatgcag acaactccac aacgagctgg 1380 agcaggtgtt tcgactgcta catcgcatac aagacgtcgt tcttctgctg gtacagatcc 1440 tttttctccg gtttcgcctt caaatccaaa tttcctgacg cctttgaaac ctatagatgg 1500 aaatcaggaa tggcagcaat cacctttaga gtctcccttg tctatgcatt ctttgcagga 1560 aagcttacac agcgttgaac ctgaatctcc gatttttcaa caggctccgc aaatcccttt 1620 gtcaaatgct tctcaacaat cctacatcaa tcattcatct gatggagctt ctcttcctca 1680 aagctccttt ttaaatttta acagtagcgg aaaacgggtc tccgtttctg ctgctgccca 1740 acagcacaaa aatctttttc ttccttatct tccccaagcg tcccttccga agttcattgg 1800 tactggtaag ttgcttgttg ggacccttca cataaatcgt aaaaatcgtt ctgatgcata 1860 cgttattacg gacgtgcttg acgagcctat ttttatttgc ggatccaagg acagaaatag 1920 gactttggaa ggggatttgg tagccgtcga acttttggat gttaatgaaa ttatgcaaac 1980 gaagagagag aaagaggaga agaagattcg ccgtaaccta tccctctctg gttcttctaa 2040 gtattcagtc aacagtaaag caaaaatgat gtctatcagt acacccatgg ctttaggaat 2100 gaataggggt gttctttcgt ttgaaaggtc tattgagaaa cggaagaacg attacgaggt 2160 aaccggccag agtctttcgt ttgtcgacga tgtttcactt actcccgatt ctgctccaaa 2220 atacgcaggt catgtcgttg ctgtactcaa cagacctagc ggtgaaactt gctcaggcac 2280 tttagcgttg tatagaccca atagccttgc tttgaagaat cagtcctctc atcgaagaaa 2340 ttcatccaca tccagtggtg aaacgggaaa aggccctaaa attgtttggt tcaaaccaag 2400 tgacaagcgt attcctctta ttgctatatc tagtgaccaa gtacccccta ccttttttac 2460 aaataacgac gattttaagg ataaggtatt tttggctggc atcaagagat ggcctactac 2520 gtccttgcat ccttttggaa cgctatatga aagtattgga acaattgggg accccaaggt 2580 ggagtacaaa gcaattcttc acgatttcag ttgccacaca tatgacttcc ctgaatccct 2640 ttctcattgt gttaaaagat tacctacgcc tatccctgca gaagagctac aaaagcgata 2700 caatttacga gataagttaa ccttcatgat tggaacgcgt gattatgctc tccatattga 2760 tacaggctcc atcgacggag tcatcacact tggaatacac gttgcagacg tcgcgtatta 2820 cgttaagcaa gatatgcctc ttgatgatga agctgccaat agagtatcag aagtacaatt 2880 gttgcaaggt tccgtaccct ttttaccgaa aaaggtctca gaagagattt cccttataga 2940 gggacatgat tgtttaacaa ttagtatagt tgtacagctt gatttgaaaa gcggcgctgt 3000 tttacagtgt tcccttgggc cctctgtaat ccacccgtca agttttatta gtttagaaag 3060 tgcacaagca aacttgcaaa ccaacgaagc gcttcagcta gttgatgcat cggcccatgt 3120 ccttaccaaa ctaagattga aaacagataa gaaacttgac ttacaatcct tatactgctt 3180 tgaattttgc gatgggcaga ttcctaatat acagaatatt aacatgagta tttttgaggc 3240 attccctatt gcatgttctt tacaacaaat tgaacattgg gtaaacgaga aagttgcatc 3300 tcatttaatg tctgtttttc ccagtaaagt gattttgcga aaaaatcaaa gaccttctga 3360 ctttgcatct cttgttgcag tttctgagtt aaccggagtg aatttatctg cttcatctac 3420 tccttcggaa atcatgaccg aaattgcaac taccaaggat aagagaacca aaatgttact 3480 acaattgact ctaagaagaa tgtgtaatga atctgaatac actatcggta cttcaaatgc 3540 taaggatgtt tcgcattttg tgttctcttg tccttactac acccattttt gtcaccctac 3600 tcgtagatat atcgatatat gtgtacagag acaattacgc gaagcctttg atggcagacc 3660 agacttttcc aaagactaca gaagtttact ttctataact cagtcttgta acacactgag 3720 caacttctac cgtaatgccc aggaaaaaag tctacatgca tatttatgtc aacttctcca 3780 ttctattaat ttacgatctg ggctcgttaa gcataaggct tttgttttgg ctgttgacca 3840 ggagtatatt gacatagtca tatacgaatt tggcttggaa agaaggatct ccttggatct 3900 gctaccgctt agtaactgcg actttaatga gcaaaaacac gaactctatt tatcatggag 3960 gacaaatgct tctttctttt atgcttcatc ttctttggaa attgatacac cttgtttcaa 4020 tgactttaag aaaaaatttt tggattccaa cgggatgtgc aaacaaatat gcgatatgat 4080 ggatgcacag gttcgggatt tagctaacgc tgctgagtcc caggagtctt tctattcaaa 4140 ggctcgaggc aatgacagta ctagtaaaac agctaaaagt tcctctggca atcaggatat 4200 ttccggagat ggaaaacttc atagtttacg tatgaaagag cctgaggttg ttcaaaccat 4260 ccgtccaggc caagaggtta gtgtacttat atttgctgat acttccgcta cttactcact 4320 ctcgttaatt actttacaaa gtcctctatc cagttaatct tcaataactg gtgatcttcg 4380 ctaatgtgta tgcctcacga tttattttta atgtatgatt aattgcatat gtctaacgtt 4440 atatacttct accacttatt tctttttacc taaacgtttt ggatttattt tagaggattc 4500 gaataatcgc atgggtttgt ttgttttttg gtggacttaa atgtttttaa ggatttttat 4560 caaaatattt taatgcttat ttacggttca tgtcttacga ttgtatttct tattggcttt 4620 ttttattcat ttttctcatt tttttttttt tatttcttta ttattttttt ttactagtaa 4680 tacttttgca tcgtttaaag ggaaaagtta tgcccttatg tttttttcaa taaaatggat 4740 tatcaaatca ttgctatcaa aatatataaa taattaaaag taaattagtt atttattcac 4800 gtcactatgg ttgataccta cccgcttaaa gttcattact aaaatcttta ttgtatttct 4860 cttattttct tctgaacagt gcagcttacc tcatatttca acagtcaacg gcatctgcag 4920 tattatccta gtatattaca aataactaat taaacatgta attttccatg aatatacttc 4980 gatcagtagt ttcgaggggt cgaaaaggcc tcaaacaaga aaaagtgaat cgtagctttg 5040 cttacttaga tatggtttat attacttcca aggtaattgc tatgtctaca ccggctgctg 5100 gaatacataa gttatatcga aacgacgaat tggatgtatt taaatatctt acaacgcaat 5160 tgaaagacaa ctggatattg ttgaatttat gtgccgaaga aacagtttac catttggaat 5220 tatttaaacc aaatgtcata aattatggat ttcaagatca taatccacct ccgcttctct 5280 ttttatgggc tattgttatg aatatggatg cactctttca aacgcaacct ttgttgacat 5340 tggtagttca ttgtaaggcc ggaaaaggac gtacaggaac tgtaatatgt agctacttgg 5400 tagctttcgg aggcttgaca gccaagcaaa gtcttgaact atatactgaa aaaagaatgg 5460 ttcgagggca cggtcttacc atttcatcgc aaatacgtta cgtctattat atcgaaattt 5520 taaaacagtt cccgaattat ttgaaagctg tggaatttaa tactggtacc acttttttta 5580 aaagttttaa atgtttgaat attaaaaaaa attcatcttt gattctatca ttgcatgcct 5640 tctctaaggg acgaaacata aatccagttg ctctgtggaa gagttcagat atatcatccc 5700 ataatgtaag cataaaagaa ggaaaacgta tatgggggat acaatgcaac ctagaaacat 5760 cggagaaaga ccttttgctc agagtcgaac gcaagggcca gttttacttt ccttcgagtg 5820 tgcaatgttg gtttcatact cactttcaac ctatgcttgt ggaatacaca aacgggataa 5880 attttcaaca aggtataaat tcctttctgc aaggacaaca gtcaatttcg ttctcctggt 5940 ctgaaatgga taatagccga cgaagtgacc cctttttcga acaactgaca attgtatatg 6000 aaaatgtttt ttgatatttt gtaaatatta tattagtgta aaataaaatg attatttgtg 6060 caattagatc ctcctttcga tcatcgaaat aaactcacat gttgaagtgt ttctacttca 6120 gtaaattaca gaggcgcttc aagttttttt tttaaatttt aaaaaaaaca taggagtttg 6180 agtttaaggc ttatactcta agattcgagt ttgcagttac gatttatggt attaactcat 6240 cgtggctaca ttaccgacat ccacttgaat tgagcttgtc ttccaccaac gcttgttaat 6300 cgctgaattg actctcatgt ctgggatatc actatccttg cgtcaattgg attatagaga 6360 ttggtttcag cgaaaaagta tgctcttgtt ttgtttttga atgatgctaa ctagtttatt 6420 agtcagtcga gatatctacg gcaattcgac ttggttgacc ggtatagatt tgcagaaaga 6480 attaactggt catacgggat gtgttaatac actagagtaa gtgttttata acaatttgtt 6540 ctacaatgct tacaattttc agctggtccg cggacggtga attcttgtta tcaggaagtg 6600 atgatacaag actaattgtc tgggatgttt tcaatgaata caagccacgg catttaatat 6660 ctactggcca tgttcaaaat atcttcagtg cgaaatttgt cccatattct aataaccggc 6720 aaatattgtc tgctagtggt gataagctta ttaagttgtt tgatttagat tcaagtaaag 6780 aaggaggaat ggatcacggc atggagactc aaactagatg ttggagttgt gctcttgatt 6840 ctgttaaaaa catcgtccct tgtgacaatg gtcatacttt tctagtttgc agtgaagatg 6900 ggacggctcg tcaatacgat attcgtgagc cacatgtctg caatcaagat ttggattgtc 6960 cttctatact ggtaaattat aacccatatc gcatcaattt atacactata accatgtccc 7020 cttcaaaccc ttattatttt gcaattggtg gtactcatcc gtacgcgttt ctatatgatc 7080 gccggatggt taaaaaatct ttccgggatg attggactat gaacacttct cccgaaaaag 7140 actgccgttg tgttcgtaaa tttagtccag atggctcatg taattcccaa ggtatcttgg 7200 atcgttatat cacttgttgt cagtttagtg ctgctaatcc taatgaggta agtcttattg 7260 catgggtgat ctctaatgtt tgttatagtt gcttgtcagt tggaactctg attatgtata 7320 tttattccat gttcatgaag ataaatctta tacaccaact tttaataaaa tagaggattc 7380 aaataaaaag ccgtctaagc cttcgttact tcaaacacag ccgctgaaaa ggaaaaatta 7440 ctcgccatgg tataagaata actttggtgc ttctactcca gctagtagag tgtcaagaaa 7500 tccgtataca gcagcccaac ctcgaaagca tacattttat cagatgtatg agaatatcga 7560 aaagtttttt actaccgaaa atggaggact gtatgagagc attgttagcg gtcgtttatc 7620 tcatttttct cgctctattc agtacgttaa agacgctatt tatttcttgg aaaattataa 7680 ttatattccc gattcaaacg gtttgaatca tagtatccgc gttagtgctt tacgttattg 7740 gagagcgtgt gtttctattt tagcgcttat ggatgatact gtgagtttgg aaccgaacac 7800 cattatacaa gctggctggg gatggttgta tgattttatg aattgggtta cacgatattt 7860 gttaggaata tcggaccatt gggcactaca aatgtctccg cctacgaacg ttgctcgcca 7920 aaactttgtt ttgtgtgatc ctgatgaacc atctcgggtt ttattctcaa atccctctga 7980 aatgattagg gcatttgcta ggatagatac taatgattta tcttctgtaa ggcggttttt 8040 ttggatacat aaagttttac gcggttgtct tcttcttata tcctccgata tctactggga 8100 gcaatttcag ccttgggaca gcagtacttc tgacgttact tccagccaaa gacttgatga 8160 tgaaaacggg ttcttgacat tgttggaacc gccagtgaac tatgaaaatg aagttgaaag 8220 tagttcggga gaaaatattg tcagtatgta tactgggcat tctgatctca atgatgacga 8280 tgatgattac caggatgagg aaagttactc ctatgctagt gatgatgatg atgaaagtga 8340 tgaggattcg gatgaaggtc cgactttgtt gtctttaaga atgaagaagc ggaaagcagt 8400 ggaaccaaat gtgccggtga acacacatgt taaaagttat tatggtcact gcaacgtaga 8460 gtctattaaa aatgttaatt tctatggtca aaatgatgaa tatgtcatga gtggttctga 8520 cgatggcagg ttttttattt gggataagtt aaatgcttcc attcttgcaa ttatccatgg 8580 cgatagtgaa gctgttaacg ttatagaagg gcatccccgt tgtcccacgc ttgctgtgtc 8640 cggtattgat tccaccgtga agatattcaa tactgagaac actccaccat caggttgttc 8700 aaggaaccat acttccaata gttacaaaat aattgctacc aatgaaatga ataggcagca 8760 ggggtcgcga gattcctaca taacgaggtt tgttgaatac ttctaatttg ctcatgtaaa 8820 tactaaccgt tcttctagtc gtatgttgtc acatcttgca tatcgtgcac atttggatga 8880 tgggtttgga cacgaagtgc tcgataccga tgcttgtagt attatgtaac tgaggaagtt 8940 ttttttgaag ctcacatttt ctctattaaa actatttatg attaatgatt agacattttc 9000 aagtaaactt aatgttgtga aataactata tgattttact ttttgggata aagttgggaa 9060 tttaagcgaa gtagttaaaa gcaagacaat ttcggcatat tcatttggac aaatattaag 9120 tgcgtatgac tgcagatgtt taatagtcat tttttatata agcttttctt taaaagtaaa 9180 atattaaatt ttaattttct tgaaacatcg tcttcaaagg aaaacggcaa gcatagcaat 9240 ccctcttatt ttctgtcttc cgtcgatcgt ctacctactt aatcatagtt tgaagttaaa 9300 attgttttta acgacatcat ttttttaagt aactgttgta ttcgcattac tctgaaaaga 9360 attaattcat acttagtttt gattagtcat atagttctgt ttttactttt taatttcgct 9420 ttcttttgct gacaaaaatt aaggcagaat tttttacgcg agatgacgat cgactgatgt 9480 acgttagaaa tgtttgttgt aacttccaat cttaattttt tttttgttta cataagcaac 9540 aagatgattt tgcactttta atactgctta ctgaaacgac ttagaatacg atggataatt 9600 gaaagaagga atctcacata attgactaat caatcaatat atgcttactt tacacttagt 9660 aaacattcac gttgattagg taaggcacga agggtatatt aggagaagaa tgtagccaga 9720 caattgtacc agcaagtgtg ggcaaataat ctgtcaagtt tttaataaag ttaaccgaga 9780 ccaaaaaata gaactaactt tggtttttac atacggtcat ttaaatggga tttttaaggg 9840 aaaccgtttt cggcgaattg gtcgaatacg tttctcacaa ctccaatgac aacgacttag 9900 agaaactgag agtatggaaa gacattagca aagtagattc caatgactca tgcagctcgg 9960 aatccggcga tctgaagatt catgaagtta attcagaggg acacattatt gtgcgatggg 10020 atgatgccaa cgatcccgaa aatcccctaa attggccttt gtgggcaaag cttgtggtga 10080 cttttgatat ttgcttctta acgtttgcgg tttatgtggg atcagcaatt tttactccag 10140 gtatatcaga aatgcaagaa acgatgcacg taggaactgt tcccgtagtt ttgggattga 10200 ctctttttgt acttggctat gccatcggtc ccctaatttt gtctccactc tcggagattc 10260 cacaagttgg tcgccaaaag atttatgttc tttctctcct tgtatttgtg tgtttacaga 10320 ttcccaccgc actgggatct agcttgggcg tcttattacc aatgaggttt ttggccggtt 10380 tcttcggctc gccagctcta gcgactggag gtgctacttt ggcagatatt tggcaaccat 10440 ggcttcttcc ctactttatg tgtttttggg caattggagc catcggtggt ccagttttgg 10500 gaccgttgct tggtggagcg atggtcgttg ctgaatcttg gagatggcaa ttttggcttt 10560 tgatgatgat ttctggcttt gcattgattg ttatcttctt ttttatgcca gagacttctg 10620 aatggcatat attatataag agggcaaaga ggttccgtaa gataactgga aacgaaaatt 10680 atagaacaga ggccgaattg gcatcttccc atttaagtgt tgctcagctt gcaaaggaaa 10740 ccataattcg tccgataata ctaagtattt cggagccgat agtattgtct ttaaatatat 10800 atattgggct aatctattca attttatatc tgtggttcga agctttccca atccttttta 10860 ctagcgttta ccattttacc attattgaaa atggcttggt ttacttaggt attctcgtgg 10920 gtgccttgat tactttagcc tgctatttcg tattcctgta taaagtgatg atcccagcat 10980 tcatggccag tggtggtgat tttgctccgg aaggagtttt ggtcatttca tttccagcaa 11040 cgttctttat tcccatttgc cttttctggt ttggctggtc gggaagagaa tcggtccatt 11100 ggattgtacc aatcgtcagt acgctctttt acgcatctgg ggccttttta atgtttcaaa 11160 gtatgtttca gtatttggct gcttcatacc caaagtacgt tgcatctgtg tttgctggaa 11220 acgacctatt tcgttcggct atggctgcat cattcccatt gtttgcccga gctatgttta 11280 ataatacagg cccttcctat gctccagttg cctggggaag tactatcctt ggtatagttg 11340 cttgcttaat gattcctatt cctttcgtgc tacataaatg gggtctgaaa ctgagaagcc 11400 gttcaaaata tgcttcttaa ttccactgtt gttgagatca tttaattatt tccggatttg 11460 tccgcgcgtt atcaagatgt atatgatgaa ggctatactc ccttgttcaa agataagtgt 11520 aatggacact tctctttcaa tttttataga gttttatgaa atttaatggt gttattttgt 11580 gtcgctaatt gaggtattga ttgatattat attatctatc agtttagaac gtttctagac 11640 ttgaacttgt aattgtctat ttaaataaaa tttggtatac aaaattcacg ttcaatctta 11700 aatttatttt ttttataaaa cagaaaaggt actacaaggc caataaacga atgaagttgt 11760 ggttgtattg tatttattct tgcgctttaa agcccaattg aactgtagct ttattatttt 11820 aagcccattg agcaattcaa aaagcacgca gatgtaaaga gtacaattga acccactatt 11880 ttaaattcat gaaagtaaat gggtgtaatt tatttgcgga tgcaacacat attattaatg 11940 agaataaata agtgtattat aattacaata agtaaaaatc aagtttaagc agagttacag 12000 tgctaattga attgtttgta ttttctgact cgggacgccg ttcaaattaa acattcattg 12060 aatagtgatt tgtagtgcgt ttcaaaatac atatttatat gtaaagaata ctacactacg 12120 ctaatatgta tgtcacatgt cctaattatt catcgtacta tatatgatat gatattgaga 12180 ttgattttat tgattgtcta tttctatcta tattatctaa atactaaaaa tagatctata 12240 gctgaacctc gttcctcagt ttagttataa gctatattaa tgacacaact taaatagtat 12300 aatacctata ctcgatcgct acttatatta tctgtgtatt gcaatataat aggtcacaag 12360 gaaaactcac cgcagtttat cgtatcgttt aaaacagatg ccaaactgcg taactgatgt 12420 tataatgtta atacgttaat aaacgttgtt aggttttaac gcaaacgaac aaatgtgtta 12480 atgtgtgaat ttgagaataa cctggtatag ctgttttctg accaaatact taatacttca 12540 ccagttataa aaaatggcgg ccaaaacggt tcagtatgac aatatttatt taaatctaag 12600 tgaaaaaccg ggaaaacttc gtatagcccc gagtggtctt ggttggaagt cacctagctt 12660 agcagaacca ttcacattac ctataagtga gattagacgt ttttgttgga gtcgctttgc 12720 gcgtggatat gagttgaaaa tcattttgaa aagcaaagat ccagtcagtc ttgacggatt 12780 ttcacaggag gtaaattttt ttaactaagt gttttgtttt tgaagattat actaattaaa 12840 catgctcagg acctcgatga tttgatcaat gttattaaac aaaattttga catgggaatt 12900 gagcaaaaag aattttccat taagggatgg aattggggag aagctaattt tttaggctca 12960 gaacttgtgt ttgatgtcaa ttctcggcca gcctttgaga ttcctatttc agctgtcacg 13020 aatactaatc tttcgggaaa aaatgaggtg gctttggaat tctctacaac agacgataag 13080 caaattcctt ctgctcaagt tgatgagctt gttgagatgc gtttgtatgt gcccgggaca 13140 accgcaaagg aagatgccgc tgacggtgaa gaagtagaac agaacgctgc aaatttattt 13200 tatgaatccc taaaagaaag agcagatatt gggcaagcag ctggagatgc aattgtatca 13260 ttttctgaaa ttcttttgct tacaccacgt ggacgttacg atatagatat gtatgaaact 13320 tgtatgcgac ttcgtggcaa aacatatgat tacaaggttg agtacagctc catcaatagt 13380 ctatttttac tcccaaaacc cgatgagcaa catgtggtgt ttgtcattgg attggaacct 13440 cctcttaggc agggacaaac acgctatcca ttcctagtta ctcagtttgt tcgtgatgaa 13500 gatatggaag tggatttaaa cattgaagag acagtcttaa aagaaaaata cgctgataag 13560 gtaaaagcca gctatgatca acctgctttt gaagttgtaa gtcaaatctt taggggcttg 13620 actggccgaa aagttacaac accagcagaa tttcttagtc atgagggtca cgctgcagtc 13680 aagtgttctt ataaggcgaa tgaaggccaa ttatattgct tagataaatc atttctcttc 13740 attcctaaac ctacgcttct catgaataca tccgatatta ctcgtgtaac actttcacgt 13800 gttggcatgt ctgtatccgc tgcccgtaca tttgatctta cttttaccct tcgctctggt 13860 acgtcttatc agttttcgaa cataaataga gttgaacaga gcgctttggt tgccttttta 13920 gaatcaaaac aaattaagat tcataatgac ttagcggatg aaacacagca aacattgctt 13980 acatctgcct tggacgatga agatgaggaa ggggatgagg aaatggaaga agcactatca 14040 gaagacgaag attttcaagc tgaaagtgaa agcgatgttg ctgaagaata tgatgaaaat 14100 gcagaatctt ctgatgaaga aggtgcttct ggtgctgagg gttcggagta atgatctata 14160 aaattgagca atgttaaatt ggaagtctat ttggatcaac ttttcagcct tgtcttttgc 14220 tattacaaat tttttatttt aattcttcgg aatcctcaaa gttggcactc ttgtgcattt 14280 ttatgtcaca taaggaaact tctatcgatg aatccgagtg gtaaaatcct tttagaaaaa 14340 ataacactta ccggtcaaaa tatatactgt tccacaattt tgactaggca aaattattcc 14400 aaggtcacaa gacgcctaat gactcgcatg ttttccttta tacattgcta tgacctttct 14460 attttgagaa aatcctgaga tatccatttc aaagtagcat aaacgtcttt cacaaaatca 14520 tctcgtaata tattaagaca atcgtttaaa agtgtattat ttatttatac ttatgagatt 14580 atttgtagat atcatcagta catggacttt tgaatgatgt cttttattta gaatattaac 14640 tacagtacct atggatgcat agccaaaacg tttacgacac cgttatttaa cattagtatg 14700 caataatgag aaaaatagcc tacagcaccc gggattccca tattgtctcc tacgatggta 14760 ctaacaaagc catcagacgc ttagctgcag acgggaaccg gtgttttcgc ctaggtatgg 14820 ctgacaacaa tacaactgtg ttataattat tatagtgcaa aattgtttgg atgttgaaat 14880 gtgtagtaaa aatagaagaa agtgcatact ttgcacattg atcagacgaa acgaaaaaaa 14940 aaaaaaaaaa aaactatgat tgtggtttta agaatctacc aatattttta aaatcaatgc 15000 atcgagcttt catttttccg cgccgagcat caaacaaatt gaagtactag tcataaacat 15060 agatcatgtt ttgcgttatc ctgtaattgc tacgatagct tgttagttgt tttaatttat 15120 aacttggaat acaacataaa ttacagagta agcgtttatt tgatcatttt tttatttatt 15180 accattttat tttattaaca ttccagtact tcactttcct tcatcgttat gttttacaca 15240 aaagtgctca aaaacatttc aactacacga ttatttagca attatgcata cacacagcac 15300 c 15301 //