ID SPBC4 standard; DNA; FUN; 16037 BP. XX AC AL121863; XX SV AL121863.1 XX DT 15-OCT-1999 (Rel. 61, Created) DT 15-OCT-1999 (Rel. 61, Last updated, Version 1) XX DE S.pombe chromosome II cosmid c4. XX KW 26s protease regulatory subunit 4 homolog; 5s rRNA; acid phosphatase; KW ATPase; cdc19; cell division control protein 19; mcm; mlo2; mts2; nda1. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-16037 RA McDougall R.C., Rajandream M.A., Barrell B.G., Brown S., Harris D.; RT ; RL Submitted (14-OCT-1999) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; P36612; P36612. DR GOA; P40377; P40377. DR GOA; Q09329; Q09329. DR GOA; Q9USS6; Q9USS6. DR GOA; Q9USS7; Q9USS7. DR SPTREMBL; Q9USS6; Q9USS6. DR SPTREMBL; Q9USS7; Q9USS7. DR SPTREMBL; Q9USS8; Q9USS8. DR SPTREMBL; Q9USS9; Q9USS9. DR SWISS-PROT; P36612; PRS4_SCHPO. DR SWISS-PROT; P40377; CC19_SCHPO. DR SWISS-PROT; Q09329; MLO2_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c4 is overlapped at the 3' end by cosmid c725, EMBL CC entry SPBC725, accession number AL034352. XX FH Key Location/Qualifiers FH FT source 1..16037 FT /chromosome="II" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c4" FT /map="IIL" FT CDS join(396..1084,1236..1293) FT /db_xref="SPTREMBL:Q9USS9" FT /label=SPBC4.01 FT /note="SPBC4.01, len:248" FT /gene="SPBC4.01" FT /product="hypothetical protein" FT /protein_id="CAB58400.1" FT /translation="MERGTSKFSWIGLVARIYNYIPHPSIFSNAILGIAWLFLIFLCCS FT CLTKSSIFARLLRVKNETTTVDVGFFGVCDQAINSTSRVCHELRNWDQTTGGLAYETSR FT FAWLQVHPVLLAIVVVFSTLSIVLTILKYLAPAYIRQWSISCLTTSTAACLLLALQMAL FT AHISANSYAVGMNLTGKATAKFGVAAAVFGWISSGFFLLFSLIHLGLWTIERNKQKLFE FT ETSLSFSFITTKLRLIETQYFICKDY" FT misc_feature 1085..1090 FT /note="gtaatt, splice donor sequence" FT misc_feature 1220..1235 FT /note="ttaacacataaaacag, splice branch and acceptor" FT CDS join(complement(3056..3293),complement(2707..2815), FT complement(1586..2609)) FT /db_xref="SPTREMBL:Q9USS8" FT /label=SPBC4.02c FT /note="SPBC4.02c, len:456" FT /gene="SPBC4.02c" FT /product="hypothetical protein" FT /protein_id="CAB58401.1" FT /translation="MSLNVDIGLGTYDFSKWGYIDVHKIKEVHIYDFDNVRLNPWKDRM FT SVKTNSLLQTLFQTPLPNANIWSNQAIRILMAFNILANGGWFFDPHVLAATGDGVEVEE FT KRAWEGWWNEKIVSQARESIRRPDVLAVLLTGRNEGFRGIVEKIIASKGLDFQGVVFKL FT QAPDGFWPQTLNFKLWFFNEVYRHFLYINSTRIYEDRPSHIEAFSAWLTERKKKNKNAD FT FEIIAVAEPPKYLKFKVEIALVRGMLTAHNLKAPSLKLPLYKFVKNVIATVVTVPVAEL FT HHIRNAFFNIPIAEIMESVSANSSRRNSHDSNSTIICEPEYPPDTSFNSSPGRLWIVTA FT IGRYRDEYWTVRAEAAEGYDCEKIHEIDVADIPSLYGTILYVSMSTGIVKSEIGDIGAQ FT QWKTLAPSERWILRTNIRKECTYDIRYKRPYVSSLKYSDDDLTAGRASPMTGPTKRK" FT misc_feature complement(2610..2622) FT /note="ttaatgtgtatag, splice branch and acceptor" FT misc_feature complement(2701..2706) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(2816..2834) FT /note="ctaaccttttttttttaag, splice branch and acceptor" FT misc_feature complement(3050..3055) FT /note="gtatgt, splice donor sequence" FT CDS complement(4106..6781) FT /db_xref="GOA:Q9USS7" FT /db_xref="SPTREMBL:Q9USS7" FT /label=SPBC4.03c FT /note="SPBC4.03c, len:891, SIMILARITY:Caenorhabditis FT elegans., Q19371, f12f6.6 protein., (1126 aa), fasta FT scores: opt: 1311, E():0, (32.0% identity in 827 aa)" FT /gene="SPBC4.03c" FT /product="hypothetical protein" FT /protein_id="CAB58402.1" FT /translation="MAYPGQFGNYGNPETYRQNVAGNIASYGGPEIDTQLAAQMNAQMY FT IQQGSAMAPQPRRARRHKDAHAYDMSLTDAEPALAPVMSPAIPPSMNYPTPSTPSVLPE FT SFSNDTNLLDPAALPSAPEVRYEDQQLFKNQIFNTMEKGSPPMSTTDFVGYEQGNSSSK FT FVQFTSYAIPATNDVCNASGIPLGMIVQPFAELRPDEAPVPVVDNTNSNPPRCKKCRGY FT INPFIQFTMASSKWTCNLCGSENSFNDDGFNPLVGSQHDGVESRPELNVGTIDFKVGKD FT YWIKEDPPKPARFVFMIDVSYEASSKGLPKVAAEAIRNILYGPVPLDPNVKIAIVCFDR FT SVNFFNLSPNLEQPHMLAASDLENPFVPFSSGLFVDPIASKVVIERLLDSFPAIFQDVK FT IPEPVVGNALEVVKLLLKETGGKAFVFVSALPTMGLGKLRHREDQRLYGTSDEKNLWNT FT QDKWYTSLADEYVTAGIGVDIFFTATAYVDVATVGSVATLSGGQIYHYSNFVADRDGSR FT LKQDLFRSVTREQGYRVMLKTRCSNGLRVSKYLGNFLQRTPQDIEFGSLDADKSVTVLF FT SYDGKLNGALDAHFQTAVLYTTPSGERRVRVVNYCCAVTSKSYDTISLAIVEPIVAVLA FT KIASTNIAAGSLKDTSVRLVEGVVKILSSYRKVAANRLTPGQLVLPKNLVLLPILILAV FT LKSSAIRSGSIHSDIRVSQLREVRAAPIQELMLNLYPNIYALHQLQPTDCLPDPENTGC FT LPINMPLCVRASRKFIEDGGAFLIVTGQKSYLWFHQRTSPLLLQDLLGVESLEDIDSLK FT ALELPTLDTVLSVQVRNLLSSLRMQFPSMALHPQIVRQGLDGSEGEIFSTLVEDNTREG FT FGYLDFLTKIHESLHTQGYK" FT CDS join(complement(9845..10077),complement(7366..9625)) FT /db_xref="GOA:P40377" FT /db_xref="SWISS-PROT:P40377" FT /label=cdc19 or nda1 FT /note="SPBC4.04c, len:830" FT /gene="cdc19" FT /gene="nda1" FT /gene="SPBC4.04c" FT /product="cell division control protein 19" FT /protein_id="CAB58403.1" FT /translation="MDSFRKRGRRDSESLPFESENSSLGATPLSLPPSSPPPEFSDEAA FT EALVEEDIEDLDGEALDVEDEEGEDLFGEGMERDYQQNLELDRYDIEELDDDNDLEELD FT IGARRAVDARLRRRDIELDAAAGRTKPAAFLQDEDDDLDSNLGTGFTRHRHRIYDEYSP FT NVGALDESGELPLESIADVKADSIAEWVTLDPVRRTIAREFKNFLLEYTDENGTSVYGN FT RIRTLGEVNAESLMVNYAHLGESKPILAYFLANAPAPIFRIFDRVALEATLLHYPDYER FT IHSDIHVRITNLPTCFTLRDLRQSHLNCLVRVSGVVTRRTGLFPQLKYIRFTCTKCGAT FT LGPFFQDSSVEVKISFCHNCSSRGPFVINSERTVYNNYQRITLQESPGTVPSGRLPRHR FT EVILLADLVDVAKPGEEIDVTGIYRNNFDASLNTKNGFPVFATIIEANHISQLDGSGNT FT DDDFSLSRLTDDEEREIRALAKSPDIHNRIIASMAPSIYGHRSIKTAIAAALFGGVPKN FT INGKHKIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFATGQGASAVGLTASVRKDPI FT TNEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARC FT TIIAAANPIGGRYNTTIPFNQNVELTEPILSRFDILQVVKDTVNPEIDEQLANFVVSSH FT IRSHPAFDPNMDVLKKVPTETGIDAKPIPQDLLRKYIHFAREKVFPRLQQMDEEKISRL FT YSDMRRESLATGSYPITVRHLESAIRLSEAFAKMQLSEFVRPSHIDKAIQVIIDSFVNA FT QKMSVKRSLSRTFAKYLI" FT misc_feature complement(7429..8976) FT /note="Match to PF00493 MCM, MCM2/3/5 family Score 1129.10" FT misc_feature complement(9626..9637) FT /note="ctaactgtatag, splice branch and acceptor" FT misc_feature complement(9839..9844) FT /note="gtaagt, splice donor sequence" FT CDS 10323..11312 FT /db_xref="GOA:Q09329" FT /db_xref="SWISS-PROT:Q09329" FT /label=mlo2 FT /note="SPBC4.05, len:329" FT /gene="mlo2" FT /gene="SPBC4.05" FT /product="mlo2 protein" FT /protein_id="CAB58404.1" FT /translation="MEETAHELTVKQYVEQQRELEREAREVLPYSFDTCTYSMGYLKQP FT LYACLTCQKASGSLNAVCYSCSISCHADHDLVDLFNKRHFRCDCGTTRTHSIPCNLRKS FT VDECGSENDYNHNFEGRFCICDTVYNPETEEGTMFQCILCEDWFHEKCLQKTNKGIAIP FT DAETFEWLVCSECSEKYRDHLLNQKHESIAGTERAPLFLSENFRENLCPCESCISLRNL FT EMPMLVAEEPIYEPPEDSEDGISEMNEDPSESGEMIEQVISSTMNDVLRILDRLPRVQA FT NESVYAYNRLKSELTDFLTPFARENRVVTKEDISNFFLERSRISKNLR" FT CDS 11983..13371 FT /db_xref="GOA:Q9USS6" FT /db_xref="SPTREMBL:Q9USS6" FT /label=SPBC4.06 FT /note="SPBC4.06, len:462, SIMILARITY:Drosophila FT madeirensis, O97186, acid phosphatase-1, (447 aa), fasta FT scores: opt: 265, E():3e-10, (25.8% identity in 310 aa)" FT /gene="SPBC4.06" FT /product="putative acid phosphatase" FT /protein_id="CAB58405.1" FT /translation="MSQMSSASVKFPDSVPGVDYPKQLQLKYLQVIFRHGERAPVKERL FT GSAGIPKDWKLCNNARRFFAQIKGEKEWSVLGFERKVESPVDTSLAAPTSDNSPSGVCI FT HGELTDFGRVTTRTLGEYLRERYVKQLKFLPDELNNYADVYMRATPMVRALESLEHVFS FT GLYPESKRKMGLPVIFTRNWSDENLLPNENNCPRLVQLYEEFAERAAKLYDPLLAGRAS FT EMMSQFMNGQPVRVVSSHPRLSGLLDTINAAIGSHVDFNPNLRDEQWLRDAETAVVEEW FT FGGYKVSKLMRQLGAGSLLNDLSMRMENFVVAEKNGSPYHRLALYGAHDVTIAAILASL FT DAFDYRWPPFTSHLEMELFEDTSSKSDSQNQSGDNKTTDLKLFSDESTDASNSAIVAAS FT NSARDMSDWYVRITYNSTPVVMGACRGQGYKGNDTICPLSIFKDTVRALKPVEYHTMCK FT PVKK" FT misc_feature 12067..12108 FT /note="Pfam match to entry PF00328 acid_phosphat, Histidine FT acid phosphatase," FT misc_feature 12940..13056 FT /note="Pfam match to entry PF00328 acid_phosphat, Histidine FT acid phosphatase," FT CDS join(complement(15346..15348),complement(13867..15210)) FT /db_xref="GOA:P36612" FT /db_xref="SWISS-PROT:P36612" FT /label=mts2 FT /note="SPBC4.07c, len:448" FT /gene="mts2" FT /gene="SPBC4.07c" FT /product="26s protease regulatory subunit 4 homolog" FT /protein_id="CAB58406.1" FT /translation="MGQAQSGNFSNFGDGANGDNKKDQKKDKPKYEPPVPTRTGRRKKK FT AQSGPDASAKLPTVIPTTRCRLRLLKMQRIHDHLLMEEEYVQNQERLKPQDERTQEERN FT RVDEIRGTPMSVGTLEEIIDDDHAIVSTAGPEYYVSIMSFVDKDMLEPGCSVLLHHKAM FT SIVGLLLDDTDPMINVMKLDKAPTESYADIGGLESQIQEIKEAVELPLTHPELYEEMGI FT KPPKGVILYGAPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPRLVRQLFNAAE FT EHSPSIVFIDEIDAIGTKRYDAQSGAEREIQRTMLELLNQLDGFDTSQRDIKVIMATNR FT ISDLDPALIRPGRIDRKILFENPDEATKRKIFTIHTSKMNLGEDVNLEELIQCKDDLSG FT AEIKAIVSEAGLLALRERRMRVVMDDFRQAREKVLKTKDEGGPAGGLYI" FT misc_feature complement(13969..14535) FT /note="Match to PF00004 AAA, ATPases associated with FT various cellular activities (AAA) Score 297.08" FT misc_feature complement(15211..15225) FT /note="ctaactctcctatag, splice branch and acceptor" FT intron complement(15211..15345) FT /note="confirmed intron" FT misc_feature complement(15340..15345) FT /note="gtaagt, splice donor sequence" FT rRNA 15851..16035 FT /note="5s rRNA" FT misc_feature 15936..16037 FT /note="nominal overlap with cosmid SPBC725 S. pombe FT chromosome 2" XX SQ Sequence 16037 BP; 5139 A; 3007 C; 3043 G; 4848 T; 0 other; gatccgaaat aatgattttt tgataattta cggaattggt tgcgaagttt ttagactggg 60 ttctttacga tgattatttg ctcaataatg tctactactc gcctattcat tcagtttact 120 cttatacact tcaagggacc tatcttttca tttatcatga cgatggttta aaaataataa 180 ataattgatt tgattgaaag gcggcacagc atttatcggt attaagtatg tgtagtactc 240 ataatttctt tgtcctcgaa gacaaagaaa cataacagtt acgtgtcaaa aatttctttg 300 tttcaaagta ttataataga cttacattcc ataatagttc ttctatccct aaactaattt 360 tgctaaagta aacaatttaa aattacggtt taagaatgga aagaggaact agtaaattca 420 gctggattgg acttgttgca agaatataca actatattcc tcatcctagt attttttcga 480 atgctatttt aggaattgca tggctttttt taatattttt atgttgcagc tgcttaacga 540 aatcatctat ttttgcgaga ttactaagag taaagaatga aacaaccacc gtagacgtcg 600 gtttctttgg agtgtgtgat caagctatta attcaacgtc tcgagtttgc catgagcttc 660 gaaattggga tcaaacaact ggtggtttag catatgaaac ttcgagattt gcgtggcttc 720 aagttcatcc tgttctcctc gcgattgttg ttgtattttc aacactatcc attgttttga 780 ctattttaaa gtacttggct cctgcataca tacgccaatg gtcaataagt tgtttaacta 840 ctagtacagc cgcctgtttg cttttagcac tccaaatggc tttagctcat atttcggcta 900 attcatatgc tgtaggaatg aatttaactg ggaaagctac agcaaaattt ggggtagctg 960 cagcagtttt tgggtggatt tccagtggat tctttttgct attttcgcta atacatttgg 1020 gactttggac tattgaacga aacaagcaaa agttatttga agaaacatct ctctcattta 1080 gcttgtaatt attacgaaaa gaatgttgga cgacattgaa atgactacta ttaagtaaaa 1140 tcgcacttat gatactcttt aaacgtatat gacagatacc cttttgactt ttttaaaact 1200 ataactaaat ttcatttaat taacacataa aacagcatta ctactaaatt aagattaatt 1260 gaaacacaat acttcatttg caaagactat taaacaaaca taaataagat tttgtaaacc 1320 atattactaa tttgagcaaa aatgtattga gaattagctt ttaatgaatc ataaaccatt 1380 aaatataaat taactaatgt tgaaaacaga caatctaaaa ttgcaaatgt tacgaaccaa 1440 acgatcagat gtatatgcct aagattggta atctaattat aatatattga aagtgggaga 1500 cttaaataaa aaaaagagaa aagaaaagaa aagtagcata acttaataaa ggatattttt 1560 gaaaagggat ggaaaatact caactttact tgcgttttgt tggaccagtc ataggagaag 1620 cacgaccagc agtcaaatca tcatcggaat atttcaacga cgatacataa ggtcgtttgt 1680 atcgaatgtc atatgtacat tcttttctga tatttgtacg aagaatccat cgctcggaag 1740 gtgctaatgt cttccactgc tgagctccaa tatctccaat ctccgatttt acaataccag 1800 ttgacatgga cacgtataat atagtgccat aaagagaagg gatatcggcg acatcaattt 1860 cgtgtatttt ttcacagtca tatccttctg cagcctcagc acgcaccgtc cagtactcgt 1920 cacgatatct tccaatcgcc gtaacaatcc acaagcggcc agggctacta ttaaaagacg 1980 tatctggagg atattcgggt tcacatataa ttgttgaatt agaatcgtgt gaattcctac 2040 gtgaagaatt agcgctaaca ctttccatta tttcagcaat tggtatgtta aaaaaagcat 2100 tgcgaatatg gtgaagctct gcgacaggta ccgtaacaac agttgctatc acattcttca 2160 caaacttgta taagggtaat ttcaaagatg gggctttcaa attgtgggca gtgagcattc 2220 cacgtacaag agcaatctca actttgaact tcaaatactt gggaggttcg gcgacagcaa 2280 taatttcaaa atctgcattt ttattctttt tttttcgttc tgtcaaccag gcagaaaatg 2340 cttctatatg ggagggtcga tcttcatata tcctcgtgga gttaatatat aggaaatgac 2400 ggtaaacttc attaaaaaac caaagcttaa agttgagtgt ttggggccaa aaaccgtcag 2460 gagcttgaag tttaaacaca accccttgga aatctaaacc cttgcttgca atgatttttt 2520 ccacgattcc tcgaaaccct tcgttgcggc cagtaagtaa taccgctaaa acatcaggtc 2580 gacgtatcga ttctctggct tgtgaaacac tatacacatt aataactata gacacatgat 2640 atatgttctg attccatctt ttcaatgcca aagtcgacag tacgaaaccc gaattccaat 2700 acttacattt tttcattcca ccagccttcc caggctctct tctcctcgac ctcgacaccg 2760 tcaccggtag cagctaaaac gtgtggatca aaaaaccatc cgccattagc caaaacttaa 2820 aaaaaaaagg ttagtaaatg atcattgtaa gcaagtctca tcaatgaagt cagtaaggaa 2880 gaaagcaaac agtgaaagag tttactgaag tataaaagtg aggacataaa taattgcatc 2940 tcagacgcat ggtacatgaa aaaatccaca ctatggtgaa cagacaacca ctatgccaaa 3000 ggtaaacacg tcgttttttt ccatctggac ttgttaagac taaccattaa catactatta 3060 aatgccatca aaatccgaat cgcttgattg ctccatatgt ttgcatttgg caatggagtt 3120 tggaacaagg tctgcaaaag gctgttagtt tttacgctca ttctatcttt ccagggattg 3180 agccttacat tatcgaaatc ataaatgtga acctctttga ttttatgaac gtctatatat 3240 ccccattttg aaaagtcata ggttccaagc ccaatgtcaa cgttcaaact cattaaacta 3300 aaggccgatc cagtttaaac gtcgaaaatt aagttcttaa ataataagat aaaagtttcg 3360 ccaaaaattg cttttttttt tatctcaaaa ttaactaagc cagcatttga aaggtgaaac 3420 tacaaaatcc cgtactagcc catatactgc acattttacc gaacccgacg ctattgctaa 3480 ccgtcccgat atactaatgc caacatacaa aacgaagtac tgtcgaatca atcaataaaa 3540 gtcttaataa tgcaaacatt tagtgttaat tttatttcat cccatagtaa tcgtatatta 3600 ttaaacataa gtttcttcaa gccgagaact ttggtaactg aaagcgaaaa caaaggtaaa 3660 caatggactt cgcattgtaa aagaaagaat agagaaaata gggataacca taaacaaatg 3720 aagaagtaca tacgaaaaaa ttatgtgaag agcgtttttt ttttttttga aaagttgata 3780 cgctctaaaa ggaactaacc ataaactcaa ctttataaat gctctatact attgacaaag 3840 aaatgaatgc tcaacaagtt attgcatgca atattccatt ctgaaatata gtgctgtcca 3900 agtaaacttt agttaatata ggaacgacag cgaagatatg ctttattcta acagaatatg 3960 cttaattttg aatgaaaggg gctcaaaaat gattcctttt tctcggcatt aaattcggtg 4020 caacactata ccaaccaaac ccaaaacata tccacaaaga gattctttac ttttgtatcg 4080 aactgcaaga agatttgagc tgtttttatt tgtagccttg agtatgcaga gattcgtgaa 4140 ttttcgttaa aaagtctagg tatccaaatc cttcgcgagt gttatcctct actaatgttg 4200 agaatatttc accttcacta ccatctaaac cctggcgtac gatttgtggg tgaagagcca 4260 tgctgggaaa ttgcattcta agagaagaaa ggagattgcg aacttgtaca gaaagaactg 4320 tgtccaatgt cggaagctca agcgctttca gagaatcaat atcctcaaga ctctcaacac 4380 ctaatagatc ttgaagtaaa agaggagagg ttctttgatg aaaccataag taagactttt 4440 ggccagtgac gattaaaaaa gcaccaccat cctcaatgaa ttttcgagat gctcgaacgc 4500 aaagtggcat attgataggt agacaacccg tattttcagg gtcaggaaga caatcagtgg 4560 gctgtaattg atgtagtgca taaatgtttg gataaagatt tagcatcaac tcttgaatag 4620 gagctgctct cacctctctg agctgtgaaa cacgaatatc actatgaatg cttccacttc 4680 ggatagcaga tgatttcaaa actgcaagaa tcaaaatagg taataacacc aagttctttg 4740 gaagaaccag ttggcctgga gtcaaacgat tagcagcaac cttccgataa ctagataaga 4800 ttttcacgac accctccact aacctaaccg atgtatcttt taaagaaccc gctgcaatat 4860 ttgtcgatgc aattttagct aaaactgcaa cgataggttc aacaatggca agagaaatcg 4920 tatcgtagct tttagaagtg acagcacagc aatagttaac aacccttact cttctctcac 4980 cagaaggagt ggtatataaa accgcagttt gaaagtgagc gtccaaagct ccatttaatt 5040 ttccatcata ggaaaacaga actgttacac ttttatcagc atcaagactg ccaaattcga 5100 tatcttgtgg agttcgttgc aagaagttgc ctaaatattt ggagacacgc agaccatttg 5160 agcatcgtgt cttcaacatc actcgatagc cttgctctct ggtaacactt ctaaataaat 5220 cttgtttaag tcgagatcca tcacgatcag caacaaaatt actatagtgg taaatctgcc 5280 caccacttaa ggtcgcaaca cttccaacag tagcaacatc aacataagca gtagcagtaa 5340 agaaaatatc aacacctata ccagcagtaa catattcatc ggcaagagat gtataccact 5400 tgtcttgggt gttccaaaga ttcttttcat cagaagtccc atataatctt tgatcttcac 5460 gatgccttaa tttccccaat cccatcgtag gaagagcact aacaaaaaca aaagcttttc 5520 cacctgtttc cttaagaagg agttttacta cttccagtgc attgccaacg actggttcgg 5580 gaattttaac atcttgaaaa attgcaggga aactgtccag caatctctca atgacaactt 5640 ttgaagcaat gggatcaaca aaaagaccgg aagaaaatgg aacaaaggga ttctctaaat 5700 cagaagcagc taacatatgg ggttgctcta aattaggaga taaattgaag aaattaacgc 5760 ttcgatcaaa gcagacaata gcaattttga cattaggatc aagaggtacc ggtccgtaga 5820 gaatattccg aatagcttca gctgcaacct tgggaagtcc tttggaggaa gcttcatagg 5880 aaacatcaat cataaaaaca aagcgagccg gctttggcgg atcctccttt atccaatagt 5940 ccttccccac tttaaaatca atagtgccaa catttaattc tggacgagac tccactccat 6000 catgctgact accgactaaa ggattaaaac catcatcatt aaaactattt tctgaaccgc 6060 aaagattgca agtccattta ctacttgcca tcgtgaattg gataaaagga ttgatgtagc 6120 cacgacattt tttgcaacgt gggggatttg aatttgtgtt atctacaacg ggtacgggtg 6180 cttcatcagg acgtaactct gcgaacggtt gaacaatcat tcccaagggg attccggaag 6240 cattgcaaac atcattggta gctggaatcg cgtaactggt aaactgaacg aatttggaag 6300 atgaatttcc ttgttcatac ccaacaaaat ctgtagtgga cataggtgga gaaccctttt 6360 ccatggtatt gaatatttgg tttttaaaca attgctgatc ttcatagcga acttcaggag 6420 ccgaaggtaa tgctgcagga tcgaggagat ttgtatcatt agaaaaagat tctggaagta 6480 ctgagggtgt acttggcgta ggataattca tggaaggcgg gatagcaggc gacatgacag 6540 gagccaaagc tggttcagca tctgtcaatg acatatcata tgcatgggca tctttatgtc 6600 ttctagcgcg tcggggttgt ggagccattg cactaccttg ctgtatatac atttgtgcgt 6660 tcatttgagc agctaactga gtgtcaattt cagggccccc atatgaagca atattgccag 6720 caacattttg cctataagtc tcaggattac cgtaatttcc aaactgcccg ggataggcca 6780 ttttgttttt gtgtcaagtt tacttggtgg atgtacgaat ataagtaggt aagggtaggg 6840 caaaatatat accaaataaa aagactgatt tgaaagagta acacgatata aataatttta 6900 gataataaag tgtgaaattt gagattcttc aggaacatca gatatgaact ggatgcattt 6960 ccgattgtca aaagttgact tccctttaaa tttggaaatg gacaatttag ctctatatgt 7020 aaaaaacctc agctgtttca aaaaatgtca tttcacatgg gcagtggctc tttaatgaaa 7080 cagctaataa tattgataca gcggagaaag tatctataca cctagtatct atagcgaata 7140 gtcaataatg atattcaaaa caagtgttat taacctaaat aatttagatt gacattttga 7200 aaactaagaa agaatgaatg taaagatagg tataaaaatg taaagcaaat tttgattgca 7260 aattattaaa ggatagatat atgcaacaga tgcagtaaca aaaggagggt caaagaacgg 7320 ggaaatcaaa atcactggac tccataaact gattgtgtca aaaaattaaa taagatattt 7380 agcaaatgtt cttgacaaac ttcgtttaac actcattttt tgggcattca caaaggaatc 7440 aataatcact tgaatggctt tgtctatatg tgaagggcgc acaaactcac tgagctgcat 7500 ttttgcaaat gcttcactta aacggatagc agactccaga tgacgcacag taataggata 7560 acttccagta gccagtgact cgcgtctcat atcgctataa agtctcgaaa tcttttcttc 7620 atccatttgc tgtaatcgag gaaaaacttt ttcacgagcg aaatggatat atttacgaag 7680 aagatcttgg ggaatgggtt tggcatcaat accagtctca gtagggactt tcttcaagac 7740 atccatattc ggatcaaatg caggatgaga tcgaatatga cttgatacaa caaaattagc 7800 tagctgttca tcaatttcag gattaaccgt gtctttgacg acctgaagga tgtcaaaacg 7860 agataaaata ggttcggtca gctcaacatt ttgattaaaa ggaattgtag tgttataacg 7920 tccaccgatg ggattagcgg cagcaataat agtgcacctc gcctgcaagg tagtcacaat 7980 acccgcctta gaaatagaaa tactttgttg ttccatggct tcgtgaatag aagtacgatc 8040 ctgatcattc attttatcga actcgtcaat caaacaaaca cctttatctg ctaaaaccaa 8100 agcaccccct tccaaagtcc attcattcgt aatggggtct ttacggacgg atgcagttag 8160 accaacagca ctggcaccct gacctgtggc gaagacagcc ctatgtgccg ttttttcaac 8220 atacttaaga aattgagatt tggcggttcc tggatctccc aacaataaaa cattgatatc 8280 acctctaatt ttatgcttac cgttaatatt tttggggaca ccaccgaata aagcagcagc 8340 aatagcagtt ttgatagagc gatgtccata aatagaaggc gccatcgatg caataattct 8400 gttgtgaata tcaggcgact ttgctaatgc ccgaatttcc ctttcctcat catcagtaag 8460 ccgacttaaa gagaaatcat catcagtatt accactgccg tcaagttgcg atatgtgatt 8520 tgcttctata attgtagcga agacaggaaa cccgtttttg gtattcagac tagcatcgaa 8580 gttattgcgg tatatgccag taacatcaat ctcttcgcct ggtttggcaa catcaaccaa 8640 gtccgctaaa agaataactt cacggtgtcg aggcagtcta cctgagggga cggtgccagg 8700 tgattcttgt aaagtgatcc tttgatagtt attatataca gtccgttcag agttgattac 8760 aaacggacca cggctggaac agttgtgaca gaaagaaatt tttacttcaa cgctagagtc 8820 ttgaaaaaat ggacccaaag tagcaccaca tttggtacat gtaaaccgaa tgtattttaa 8880 ttgtggaaaa agcccagtgc gcctagttac gacaccagat acccgtacaa ggcaattaag 8940 atgggattgt cgtagatcgc gtaaagtaaa acaagtagga agattagtga tacgaacatg 9000 aatatcagag tgtattcttt catagtctgg ataatgcaaa agagtggctt ccaaagcaac 9060 acgatcaaat atgcgaaaaa taggtgcagg cgcattggcc aagaaataag ccaaaatggg 9120 tttagattca ccaagatggg cataattaac catcaacgac tcagcattaa cctcacccaa 9180 tgtgcgaata cggttaccgt atacagaggt gccattttca tctgtatatt caagaaggaa 9240 atttttgaat tctcgagcaa ttgtacgccg aacaggatca agagtaaccc attcggcaat 9300 actatcggcc tttacgtcgg caattgattc aagaggaagt tcaccagatt cgtccaatgc 9360 gccaacatta ggtgaatatt cgtcgtaaat tcgatgtcga tgacgagtga agcctgtgcc 9420 aagattggag tccaaatcat catcttcatc ttgtaaaaat gcagcaggtt ttgttctacc 9480 tgcagcagca tcgagctcaa tatcacgtcg tctcaacctg gcatcaacag ctcttcgggc 9540 cccgatatct aattcttcaa gatcgttatc gtcatctagt tcttcaatgt cataacgatc 9600 tagctccaaa ttttgttgat aatcactata cagttagaaa aaagtacctt atttgacgcg 9660 aaatgtgaaa ctactctttt gaaaatcaag atttgttctg tcaatataac cgcaacctag 9720 gaatccaata aatatattta tttacaagaa ggagaagaaa tagtatgtaa tttatatatt 9780 gatggcaaca cttagtatac acaacattga caagacacgt ctcaagcata gctataaaac 9840 ttaccgttcc attccttctc cgaacaaatc ttcaccttct tcatcctcta catctaaagc 9900 ttctccgtcc agatcctcaa tatcctcctc cacgagagct tctgcagctt catcagagaa 9960 ttctggagga ggtgaagaag gaggtaaaga aagaggtgta gcaccgagag aagaattttc 10020 tgattcaaaa ggtaaacttt cagaatcgcg gcgacccctt ttccgaaaag aatccatctt 10080 tggactcaaa tactttaaag atgttgtttc taactatttt aatgcattga atagctagag 10140 tattgcagga tgaaagaata agaaatgcta cagtatattg ttaaattgta ttggaaaatg 10200 tagtgatacc tgtaaatgaa atagaggagc gtaatgagtt agtgttttga attattcaaa 10260 agacattctt cgcaattgtt tacgccgtct atttgccaac gtttagttgc atttaataac 10320 ttatggagga aacggctcat gaattaacgg ttaagcaata tgttgaacag caaagggagc 10380 ttgaaaggga ggcacgagaa gttttgcctt acagctttga cacgtgcact tattcgatgg 10440 gctatttgaa gcaaccttta tacgcttgtt tgacatgtca aaaagctagc ggaagcttaa 10500 atgctgtttg ctatagctgc agtattagct gccatgctga ccatgatctt gtggacctat 10560 tcaataaacg acattttcga tgtgattgtg gcaccacaag aacccactcc ataccttgta 10620 atttacggaa atccgttgat gaatgtggct cagaaaatga ttataatcat aatttcgaag 10680 ggcgattttg catatgtgat acggtgtata atccagagac agaggaagga actatgtttc 10740 aatgcatcct ttgcgaagat tggtttcacg aaaagtgtct gcagaaaact aataaaggaa 10800 ttgcaatccc agatgctgag acttttgaat ggttggtgtg ttcagaatgt tcagaaaaat 10860 accgcgatca tcttttaaac cagaagcatg aaagcatagc tggtacagaa cgagcgcctc 10920 tatttctttc agaaaacttt agggaaaatt tgtgcccttg tgaatcttgc atcagtttgc 10980 gtaatttgga gatgccaatg ttggtggcag aagaacctat ttacgaacct cctgaggatt 11040 ctgaggatgg aatcagtgag atgaatgagg atcccagtga atctggagaa atgattgagc 11100 aagtcatatc tagcacaatg aatgatgtcc ttcgtatttt ggacagactt cctcgtgtac 11160 aagctaacga aagcgtttat gcgtataatc gcttaaaatc tgagctaacg gacttcctca 11220 ctccatttgc tcgtgaaaat agggttgtca ccaaggaaga tatatcaaat tttttcttgg 11280 agcgatctcg aatcagtaaa aatttacggt agcgttaata acttttttga attcccttct 11340 tttttggcgt ataatttaac gtcaaaacat gtaggttata cttaatctgg tgatgctttt 11400 tgtgaaacgc tgtttatact ggtgaaacca gagatatttt ctatgtgctt atggttaaac 11460 gtaatcattt ctctatcaaa aatggtttaa ttgattttct taacagagat ggttaatttg 11520 agaggcttac tggggcttgt tggtatacat gattttaatg atgatgacaa atttgtatgt 11580 atatttgaac aataattaat atattgaact tctagctttc ttgtctctcc tattttaact 11640 gcactcatta aaatttttaa acctatctat agttttggtg gttgcgtctt ttatctttta 11700 tttttgattg agaaagctaa agagaaaccc tgtctgggta tttttttttt gttatatctc 11760 ataatgactt tcattttaat tttttcctaa cagtttttta agattgaatt aactttatat 11820 tttattgttt tcttttcata aacaaaacta attttcaaat agtgtcgttt cgttaatatt 11880 cagtaattca tattttatat gagctttgcg atgatgttca agcattgaga ccttagttga 11940 cagcagctct tatccagcat catcaaccac ttcctagccg ccatgtctca aatgtcttca 12000 gcttctgtta aattcccgga ttcagttccc ggagtcgatt atccaaaaca gctgcaactg 12060 aaatatttac aagtcatatt tcgacatggt gaacgtgctc ccgtgaagga aagacttggt 12120 tccgccggta tccctaagga ttggaagctt tgtaataatg caaggaggtt ttttgcgcaa 12180 attaaagggg aaaaggaatg gtctgtgttg ggttttgaaa ggaaggttga gtcaccagtt 12240 gacacgtctc ttgcagcacc aacttcagac aattccccaa gtggtgtttg cattcatggt 12300 gaattgactg attttgggcg tgttactacc agaacacttg gtgagtatct tcgagaacgt 12360 tatgtcaaac aattgaaatt cttacctgat gaattgaata actacgctga tgtttatatg 12420 cgtgcgactc caatggtgcg agccttggag tctttagaac atgttttttc cggattgtat 12480 cctgagtcaa agcgtaagat gggtttacct gtcattttta cgagaaattg gtcagacgaa 12540 aacctacttc ctaatgaaaa caactgtcct cgacttgtgc aactatatga agaatttgca 12600 gaacgagctg ctaagcttta cgatccctta cttgcaggcc gtgcctctga aatgatgagt 12660 caattcatga atggtcagcc tgttagagtt gtttcaagcc atcctcgtct cagtggtttg 12720 cttgatacta ttaacgctgc cattggtagc catgtcgact tcaatcccaa cctaagagat 12780 gaacaatggt tacgcgatgc cgaaactgct gttgtagaag aatggtttgg cggttataag 12840 gtttctaagt tgatgcgtca attaggtgct ggaagcttgt taaatgattt aagcatgaga 12900 atggagaact tcgtggtcgc tgaaaagaat ggttcaccct atcatcgttt ggccctctat 12960 ggcgcacatg atgttacaat agctgccatt ttagcatctt tggacgcatt tgactatcgc 13020 tggccaccct ttacatcaca tcttgaaatg gaactattcg aagatacatc aagcaaatcc 13080 gattcccaaa atcaaagcgg cgataataag acgacagatt tgaagttgtt ttccgatgag 13140 tctacagatg ccagcaatag tgctatcgtt gctgcgtcta attctgctag agatatgtct 13200 gattggtatg tccgaattac ctacaattca acccctgtag tgatgggtgc atgtcgaggt 13260 caaggataca aaggcaatga tacgatctgt cctctttcta tatttaagga tacagtccgt 13320 gcattaaagc ctgttgaata tcacactatg tgtaaaccgg tgaaaaagta attatttgat 13380 tgattagttt acgtcttttg tgtattataa aggcgttttg ttgcacacgt tagaattaaa 13440 tttcttaata taatcagaaa actgtgtcac tgaaattgtg aatgcgatcg attgaagaaa 13500 ataaaaaaaa agaggtatcg gagaggtatt ttctatggac acgttttgtt tgctttgctt 13560 attttacgct ctttttttta aaaaatccaa aatttaaacc gacaaggaat gcacgaagtt 13620 aataaaatac gtatgatgat ataataaatt ttatggacat ctatagttac tctataaaac 13680 ttaatgataa cttaataatc atgcatacaa tacttctcta caggattaaa taataatagt 13740 gaagatggaa atacagatat tcgtagaaac taaacaggaa ctggaaatta tttagtcaat 13800 ggcaagtatg gataaaaaga agtattgcca ttatgcgagt aaaactagtc ataaccaaag 13860 ttggacttag atataaagac caccagcagg tccaccttcg tccttcgttt ttaaaacctt 13920 ttcacgagct tgccgaaagt cgtccataac aactcgcatt cggcgttcac gcagagcaag 13980 caaaccagct tcagaaacga ttgctttaat ttctgcacca gataaatcat ctttgcattg 14040 aattaactct tctaaattaa catcctcgcc caaattcatc ttggaagtgt gaatggtaaa 14100 aattttacgt ttcgtagctt catcaggatt ctcgaaaaga attttgcggt caatacgacc 14160 tggacgaata agagccggat caagatcgct gatacggtta gtagccataa taaccttaat 14220 atcacgctga ctcgtatcga atccatccaa ctgattgagt aactcaagca tagtacgttg 14280 aatttctcgt tcagcacccg actgggcatc gtaacgcttt gtacctatag catcaatttc 14340 atcaataaaa acaatagagg gcgaatgttc ttcggcagca ttaaataatt gtctcacaag 14400 acggggacca tcacctaaat atttttgaat aagttcagaa ccaacgacac gcaagaacgt 14460 agcagaagtt tgattagcaa cagctttcgc tagtaaagtt ttaccagtac cgggagcacc 14520 atataaaatg acacctttag ggggttttat gcccatttcc tcatagagtt caggatgggt 14580 aagaggaagc tctacagcct ctttgatctc ttgaatttga gattcaagac caccaatatc 14640 ggcataactt tctgtaggtg ctttgtcgag tttcataaca ttaatcattg gatcggtatc 14700 atcaagaagt aagcctacta tactcatggc tttgtgatgg agaagtacac tgcaaccagg 14760 ctctaacatg tctttatcga caaatgacat gatggaaaca tagtactctg gtccagctgt 14820 ggaaacgatg gcatgatcgt cgtctataat ttcctctaaa gttcctacag acattggagt 14880 accacgaatt tcatctacac gattgcgttc ttcctgagtt cgttcatcct gtggcttaag 14940 acgttcctgg ttttgcacat actcttcttc cataagcaaa tgatcgtgga ttctttgcat 15000 ttttaacaac cttaaacgac aacgagtcgt tgggataaca gtaggtagtt ttgccgatgc 15060 atcaggacca ctttgagcct tcttcttacg acgaccagtt cgagtgggaa ctggaggttc 15120 gtatttgggc ttatctttct tttggtcttt tttattgtcg ccgttggcac catcgccgaa 15180 attagaaaaa ttcccagatt gtgcttgtcc ctataggaga gttaggatta aatattaaaa 15240 catgaaaaga atgtgataga gtgaaaacaa gactattcag cgatagatga aaaaattaca 15300 tttaattcag tcttgttttc agcctcaaaa tactcaaata cttaccattt tttggatcga 15360 tactctcagt gaaagtgatc tggtattggt aatatctagc ttcactcgtt ttccaccacg 15420 acactatgca agcaaccggt ggctcaaggc actctaacat attgcgtaac atagtattgc 15480 gatattgtaa tttttgaata gtgtatggta aaaacacatc ctaattttct tgagttgttt 15540 acatttcgaa cacgaaaatg tatctactgt taccaacgcg tgaatcaacc attccatttc 15600 aagagacctc actttaagta aattttcctc aatataaagt gttgtagaag taataatggt 15660 ttaaaaaagg ttaaacaatt gccatcgatt tttattaaaa ggagtacgga tctcttttcg 15720 tgcattcgtc gtgtttcttg ttagaacata gactttgcta aagtgattta accttgcatc 15780 tatcttttac ttaggaatca ttgctaaaga atatttatcc caattcaaac aacacacatt 15840 cctctcaaaa ttacatagca taaaattata taagctataa agtattttac taggtgtcta 15900 cggccatacc taggcgaaaa caccagttcc cgtccgatca ctgcagttaa gcgtctgagg 15960 gcctcgttag tactatggtt ggagacaaca tgggaatccg gggtgctgta ggcttcattt 16020 cgtttttttt cttaata 16037 //