ID SPBC3B8 standard; DNA; FUN; 33398 BP. XX AC AL022244; XX SV AL022244.3 XX DT 25-MAR-1998 (Rel. 55, Created) DT 20-MAR-2002 (Rel. 71, Last updated, Version 5) XX DE S.pombe chromosome II cosmid c3B8. XX KW ccaat-binding factor subunit php5; ferredoxin-NADP+ reductase; KW putative DEAD-box helicase; saccharopine dehydrogenase. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-33398 RA Lyne M., Rajandream M.A., Barrell B.G., Beck A., Reinhardt R., Pohl T; RT ; RL Submitted (24-MAR-1998) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk and Max Planck Institut fuer Molekulare Genetik, RL Ihnestr. 73, D-14195 Berlin, Germany GATC GmbH, Fritz-Arnold-Str 23, RL D-78467 Konstanz, Germany XX DR GOA; O59710; O59710. DR GOA; O59711; O59711. DR GOA; O59712; O59712. DR GOA; O59715; O59715. DR GOA; O59720; O59720. DR GOA; O59721; O59721. DR GOA; P79007; P79007. DR SPTREMBL; O59710; O59710. DR SPTREMBL; O59711; O59711. DR SPTREMBL; O59712; O59712. DR SPTREMBL; O59713; O59713. DR SPTREMBL; O59714; O59714. DR SPTREMBL; O59715; O59715. DR SPTREMBL; O59716; O59716. DR SPTREMBL; O59717; O59717. DR SPTREMBL; O59718; O59718. DR SPTREMBL; O59719; O59719. DR SPTREMBL; O59720; O59720. DR SWISS-PROT; O59721; PUS4_SCHPO. DR SWISS-PROT; P79007; PHP5_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 80% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. XX FH Key Location/Qualifiers FH FT source 1..33398 FT /chromosome="II" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c3B8" FT /map="IIR" FT misc_feature 1..1310 FT /note="nominal overlap with cosmid SPBC11C11, EM:AL031528 FT S. pombe chromosome 2" FT misc_feature 5..15 FT /note="ctaactgacag, splice branch and acceptor" FT CDS 16..1034 FT /codon_start=3 FT /db_xref="GOA:O59721" FT /db_xref="SWISS-PROT:O59721" FT /note="SPBC3B8.13, len:>338, SIMILARITY:Saccharomyces FT cerevisiae, PUS4_YEAST, pseudouridylate synthase 4, (403 FT aa), fasta scores: opt: 393, E():6e-18, (34.4% identity in FT 305 aa)" FT /partial FT /gene="SPBC3B8.13c" FT /gene="SPBC11C11.10" FT /EC_number="4.2.1.70" FT /product="putative pseudouridylate synthase; similar to S. FT cerevisiae PUS4" FT /protein_id="CAA18302.2" FT /translation="LKKIISNSELAQYFRPAPPHPNDRNRRRRKSNRLPDIKIGHGGTL FT DPLASGVLVVGLGTGTKQLSSLLSCMKTYRATALFGCSTDTYDSAGKIIKIAVHIPTKE FT EILSGLDAFRGDISQLPPLYSALHIQGKRLYEYAREGIPLPESIKARSMHCEELILKDF FT IPKEEHTYTDPDEFASKEAIESEELLRPIEGGAERHDLLAKTEQDINPQDGDEKINAKS FT PTTNSVTDVAKDQTVTNPKKRKFEVTDLARGSRPAIGPIAVLDMTVSSGFYVRSLIHDL FT GRQVNSEAHMVDLVRLKQGSFALDDENCFDFSEFSAPGWEEKLAAAFKIDLKGDETS" FT CDS join(complement(3059..3238),complement(2883..3014), FT complement(2533..2825),complement(2464..2493), FT complement(2264..2415),complement(1189..2222)) FT /db_xref="GOA:O59720" FT /db_xref="SPTREMBL:O59720" FT /note="SPBC3B8.12, len:606, SIMILARITY:Saccharomyces FT cerevisiae, Q06683, similar to dead box family helicases., FT (689 aa), fasta scores: opt: 875, E():0, (40.6% identity in FT 379 aa)" FT /gene="SPBC3B8.12" FT /gene="SPBC11C11.11c" FT /product="DEAD/DEAH box helicase" FT /protein_id="CAA18301.1" FT /translation="MLLNACCKKNLWPRNGSTIFRRFALKLRPYQEECLSACLNAFDEG FT KRRIAVSLATGSGKTALFPHFIKYAPTLRPNSEQCLILVHRKELALQALKHCRESLPNK FT SIEIDMGNQCASGLADVTVASVFSLKNERLLKYNPLNFKLLIFDEVHHMASPSYLRILE FT HFGAESEKSKVNVIGLTATLFRADGKGLACGLDEIVYHRHFVDMIKDNWLVEPKVINIK FT WSTDLVLADSSSFLDQEKLKKEAQSEKAIFEIPRAWLEHASNRSSTLVFCINVEHSLKV FT CNAFRKLGIDARALFGETNDSERETLIQDFRKKKFPVLVNCMVLTEGTDIPNIDCLMIA FT RPTSSPNLLTQMIGRGLRLHEGKRDCLILDFCDSLRRVSLHVDPTLAGLSPDEVENFYN FT KSKNSLANPDYDPKIYGLQSVLWYSKLRKLIEMMDNIKNKDRSIFNLSTNAWVAVGMGR FT YVLSFLQKVLIIDTNFEDGTHKISEYTKEKLGTRVYNRKRIVSDRIPSLKFAIRAAETY FT ISNLKTPRSLISRKAVWRMRPASVRQINFLKKSNLKLDEKLLTAGVAADMITKVIYGGK FT GRQVRTDKLQSYLKHDANLKRITTLKELKG" FT misc_feature complement(1936..2169) FT /note="Match to PF00271 helicase_C, Helicases conserved FT C-terminal domain Score 51.05" FT misc_feature complement(2223..2237) FT /note="ttaatttccttttag, splice branch and acceptor" FT misc_feature complement(2258..2263) FT /note="gtaagc, splice donor sequence" FT misc_feature complement(2416..2433) FT /note="ctaactcccaatgttaag, splice branch and acceptor" FT misc_feature complement(2458..2463) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(2494..2504) FT /note="ctaataaatag, splice branch and acceptor" FT misc_feature complement(2527..2532) FT /note="gtaatg, splice donor sequence" FT misc_feature complement(2826..2840) FT /note="ctaactttgccatag, splice branch and acceptor" FT misc_feature complement(2877..2882) FT /note="gtaccg, splice donor sequence" FT misc_feature complement(3015..3029) FT /note="ttaacacgtctaaag, splice branch and acceptor" FT misc_feature complement(3053..3058) FT /note="gtatta, splice donor sequence" FT misc_feature complement(3056..3184) FT /note="Match to PF00270 DEAD, DEAD/DEAH box helicase Score FT 25.50" FT CDS complement(3596..6202) FT /db_xref="SPTREMBL:O59719" FT /note="SPBC3B8.11, len:868aa" FT /gene="SPBC3B8.11" FT /product="hypothetical protein; sequence orphan" FT /protein_id="CAA18300.1" FT /translation="MSTWPIDAISKKPSVSLDYGIIGACQLLNPSGYHRAEKVENNEWT FT FARYDSYTGVELVDLDKRWDILSLNPNYKLPKLTELPAEATNSTRKATSSSFGLSVCRY FT VPRNLFSTLAKESQLASSAESIYNPHILNTFCLGKTAPSDKNRYTTTECLACSKISNET FT AENLLFLCLSSPWIFRASPTLQNTATFEEFPFYLNVSAFEFAEDPIWKFSQPVRQLVFS FT NGEPSLLFALSSCELVIFQVTYDLMFLDEPNTPGCLSAIPLRFLYADDVYNSDSFANVS FT VHPTDNSFFLTTSSSGRWTIWQFLDDGYRECFGSSFKESLQQALCSAPTSSIAYHEEEI FT NPDNTIYRAKWEEYFGGVILHNAFFILHVSLGEVPDFHLLFHCSSDVRILQVVNESMPI FT KSEFFILTTESVLWMDIQHPQKPLLEWKHNRKLDPTLKITVTATFSQNIYVSVYSQMNG FT VVQQIHFSKDRALPVSGSHPFLLLNEVQVPIRSLIIQPCYFFESSEFDRQGPFDSPFWS FT AIIDKADGSLSLHILCEKSSLKIYNLEELTGSSQVAMKFKTITPSVNTSEDDSANDQEI FT ISTPNSDFQQLSLSRLYHVLCSNRNKKNTITLDEFASKVPDFVEAFDSINHDVIITLSE FT LYDGFPLKGTFTNVAEIISHLEGTELSFYFPYMFGINYNNASFFYTSVDSIASLIHRRW FT ESNTDKSVEIPCFQSSQRRSIKNVIHYLFLSSIGVSREKIFDPSLSRKEIDSTDLLTFI FT KPFYDTEGLELNEDVRNILENWEIGKISSTYVIGDSAVETEDPSSSQFSDFYISQQQSS FT VLPSSQIATVFSQEDVPNFSSLYSESSSQTIPIMSQVVSGKYGSRPSKKKKKRSGF" FT CDS 7483..8913 FT /db_xref="SPTREMBL:O59718" FT /note="SPBC3B8.10c, len:476, SIMILARITY:Homo sapiens, FT O95476, hypothetical 28.3 kD protein., (244 aa), fasta FT scores: opt: 584, E():6.1e-30, (47.1% identity in 206 aa)" FT /gene="SPBC3B8.10c" FT /product="putative membrane phosphatase; similar to S. FT cerevisiae PSR1; possibly involved in stress response; FT Pfam-B_1537" FT /protein_id="CAA18299.1" FT /translation="MNSIARLSDEINKAILATPLDDDEADKEKLANARGRASSATLRHY FT NRRRSSYSASSLSSLSSKPTEKEVPTRNEKPKHANIMRVVVYWIRVFLKRIYTFFVHSA FT RVFLYHFLNEEKEFTLASFFWGLCRFVFFPVLLSYKRREMLPPQPSVRRPRFYSSYSYP FT SSHQDPAYSSFKRHRSSNSYSSSSNGNHVRFQPSIAEEEISFNSFSNSLNSEEDVCVSP FT MKPKEVSLMGKANSNRSGHSHQPQSTQFSPPANDNISKLPSSFTIVNDPLKSPSSSRLR FT IRNITLCADKIPRPLLNSKLPRKTLVLDLDETLIHSVSRGSRTTSGQPIEVHVPGEHPI FT LYYIHKRPHLDYFLSNVSQWFRLILFTASVQPYADPIIDYLERDKKIFAKRYYRQHCAL FT VDSSFVKDISICNIHLSRIMIIDNSPASYNAHKENAIPIEGWISDPSDVDLLNLLSFLH FT ALQYVHDVRDLLGLRLAK" FT CDS complement(9579..11372) FT /db_xref="SPTREMBL:O59717" FT /note="SPBC3B8.09, len:597, SIMILARITY:Saccharomyces FT cerevisiae, Q12136, orf ydl153c., (610 aa), fasta scores: FT opt: 889, E():0, (33.6% identity in 636 aa)" FT /gene="SPBC3B8.09" FT /product="predicted coiled-coil protein; putative FT involvement in chromatin architecture, telomere repression; FT similar to S. cerevisiae SAS10; subcellular localization of FT GFP fusion-putative nucleolus and nucleus" FT /protein_id="CAA18298.1" FT /translation="MARKKSRSSSTRKGSSLKVPEIKEKEKINAINTYEDVANSEDEFY FT NAQDKILFDADNGEQADELELSDEELVALESSSDEEDGNAEENLSENEELSGKKKDAVN FT EEELYDNKGWGRSAKSYYGGDDYDNEDYSEEDDEFDARMEEQEALRLQRKRLEKVSETD FT AIDDISQWADNSDLKSIKQDSSAAAIEELVQQISPDLPRTELLKILEAKHPEFQLFLDE FT LNQLKPQLNEIKEKLKTYPSSQLLQAQCTALSTYISFLTFYFALLKDGEEDLKNHPIMV FT DLVRCKQTWESYCGLDEVLTPTSLEEDGKTIELHEKIASASDIGASEDEEDVDMHESIS FT DNENEGIKDIPVAEDDDITLKFRAAKSKINTNIKNLDDYGEGNRLDDVDAEDKIARKRS FT LKFYANQIDQKAAKRSRAVLELSGDLDMPYKERRFERQQRLMREAAARGRNQDAGADLD FT DEDPESMGIPANVDREVEDQDDLDYYESLDKKSKMAKKLRKENHDLERDLIRASRHPEL FT IELGEGDKRGITLDIAKNRGLTPRRPKENRNPRLKKRMRYEKAKKKLASKKAIYKGAPQ FT GGYAGEQTGIKAGLVKSIKLQ" FT CDS join(complement(12365..12457),complement(11833..12201)) FT /db_xref="SPTREMBL:O59716" FT /note="SPBC3B8.08, len:153aa" FT /gene="SPBC3B8.08" FT /product="hypothetical protein; sequence orphan" FT /protein_id="CAA18297.2" FT /translation="MLTQDEVSAQLGQYMLRGYTLLDTICPKCEKVPMMRLRDNPMFCV FT SCINDLKESDASEHVTVAESAPKIASLPISKTNDAERSQQTTKAPVMERTESSHQATLS FT VYSRLISELESQLDDRLPLPHNTEFLDVSLQRIERILNLISLAKSLMSS" FT misc_RNA 13909..14000 FT /note="cDNA, clone spc00161; not associatd with an orf" FT CDS 15880..16968 FT /db_xref="GOA:O59715" FT /db_xref="SPTREMBL:O59715" FT /note="SPBC3B8.07c, len:362, similar eg. to D. FT melanogaster, Q94515, DES-1 PROTEIN , (321aa), fasta FT scores, opt:708, E():0, (44.6% identity in 323 aa overlap), FT contains PS00142 Neutral zinc metallopept idases, zinc FT binding region signature" FT /gene="SPBC3B8.07c" FT /product="putative fatty acid desaturase; no apparent S. FT cerevisiae ortholog" FT /protein_id="CAA18296.1" FT /translation="MAESTATTTAVPPPAEESWNADSEDVHQFYWTYTEEPHKSRRAAI FT LKAHPEIASLNGYEPLTKWIVLGVVSLQFTCAYLLSQSSLLSWKFFLTAYFIGAFCNQN FT LFLAIHELSHNLGFKKTLYNRAYCLFANLPVGAPFAASFRPYHMEHHAYQGVDGMDTDL FT PTRAELILFDNVLGKAFFCTFQLLFYAFRPLVVRRLPFTLMHFWNIIVQFSFDYLVVRY FT VGWRALAYFFMSSFLAGSLHPTAGHFLSEHYNMTRTRLIASGPGKETPLETFSYYGPLN FT FFVYNAGYHIEHHDFPYVAWTRIGKVRELAPEFYDNIPDCKSWCGIIYQFITDSNVGMW FT CRVKRKQKHADIPTKSMHLHVS" FT misc_feature 16198..16227 FT /note="PS00142 Neutral zinc metallopeptidases, zinc binding FT region signature" FT CDS complement(17497..19032) FT /db_xref="SPTREMBL:O59714" FT /note="SPBC3B8.06, unknown (overlaps two S.cerevisiae FT hypotheticals - putative mis-prediction in S. cer ChrIII FT region) , len:511aa, similar (at N-term) eg. to YCR61W, FT YCV1_YEAST, P25639, hypothetical 65.0 kD protein in pwp2-, FT (583aa), fa sta scores, opt:218, E():7e-16, (27.9% identity FT in 359 aa o verlap), also similar (at C-term) eg. to YCR62W FT OR YC, YCV2 _YEAST, P25363, hypothetical 13.8 kD protein in FT pwp2-, (120 aa), fasta scores, opt:303, E():8.7e-14, (37.8% FT identity in 111 aa overlap), contains PS00030 Eukaryotic FT putative RNA- binding region RNP-1 signature" FT /gene="SPBC3B8.06" FT /product="hypothetical protein; similar to S. cerevisiae FT YCR062W; putative RNA-binding protein" FT /protein_id="CAA18295.1" FT /translation="MDGMHMNSTGDNPIEIDFENYANHMNKFLMAHIICMIIAYVFILP FT AGIVLAMAKSKAHIPVQIVYVILTLIGYIFAHISHHKASPENYYKGNIHRPVGRFFMWI FT TFLIAIVGITTSILKKRMLKEYQPAAEAPGAMEDPEQALQRNSLDDGAPLLPREGNSSD FT EYLPPQSSRRDVSSEKPSIPSISFINIRSWRTIPKKWCVLQVLRYFHRILGHLWLYVGF FT FESCTGIVLLAGIFKGQHIFNGLAHWIKGAIFLWYGILSFGEYLGAFSEYGWAWNVVPK FT QLSEKRFAKYVPTKEMVESFLLFAYGVSNVWLEHLGNTDGKWNHHDLQHASLAFMLWWA FT GLCGILVESKVVHRLLNATLSATLGQRRSEDSEHSENGLPSYNVFPALTVFFTGIMMSA FT HDQTNHVSTVIHVLWGRLLAAAAIARICTYIMLYLKPPSSPWPTRPPTEIITSFCLICG FT GAMFMASSYDVVNKIRLNEMSPMLIMNISVAFTCIVMGLEVMFLILKGYASSR" FT misc_feature complement(18262..18285) FT /note="PS00030 Eukaryotic putative RNA-binding region RNP-1 FT signature" FT CDS join(complement(21132..21335),complement(19937..21043)) FT /db_xref="SPTREMBL:O59713" FT /note="SPBC3B8.05, len:436, SIMILARITY:Homo sapiens., FT G1438796, ovca1=candidate tumor suppressor., (443 aa), FT fasta scores: opt: 1557, E():0, (58.3% identity in 393 aa)" FT /gene="SPBC3B8.05" FT /product="possibly involved in dipthamide synthesis; FT similar to S. cerevisiae YIL103W; simailr to human OVCA1 FT (candidate tumour supressor)" FT /protein_id="CAA18294.1" FT /translation="MAEVKKSIPKRRFVGKKNRKENNLDGSNRDVENAALVTINSKRSA FT GRVATQIPEDILNDKAINEAIKLLPQNYNFEIHKTIWHIRLRKAKRVALQLPEGLLMFG FT CILSDIFEQFCQVETIVMGDVTYGACCIDDFTARALDCDFLVHYGHSCLIPVDQTPIKV FT LYVFVDIKIDLQHVVSSLKHNLPSNSRLALVGTIQFVGSLNSIKDALQIQDEDGKGGFY FT VVIPQAKPLSPGEALGCTSPYIEKGSVDALIYIGDGRFHLESVMIANPDLPAYRYDPYS FT HKLSIESYAHEEMKSIRYSAVEKARTAKKFGLIQGTLGRQGSPKVLENLKNTLRKNNKD FT FVCVLMSEIFPSRLGQFSDIDAWIQVACPRLSIDWGYAFPAPLLTPYEASAAFNVVPWK FT EVYPMDFYATNSLGNWTPNNPENRPLPNRKKTGPVSS" FT misc_feature complement(21044..21057) FT /note="ctaacctttaatag, splice branch and acceptor" FT misc_feature complement(21126..21131) FT /note="gtaagc, splice donor sequence" FT CDS join(21718..21734,21781..21825,21881..21901,22050..24570) FT /db_xref="GOA:O59712" FT /db_xref="SPTREMBL:O59712" FT /note="SPBC3B8.04c, len:867, SIMILARITY:Saccharomyces FT cerevisiae, YN86_YEAST, hypothetical 99.5 kD protein in FT urk1-smm1 intergenic region., (894 aa), fasta scores: opt: FT 1684, E():0, (38.9% identity in 947 aa)" FT /gene="SPBC3B8.04c" FT /product="DASS transporter of unknown specificity" FT /protein_id="CAA18293.1" FT /translation="MKFSHSLQFNAVPEWSESYIAYSNLKKLIYSLEHEQITLQQGAPD FT EETRLLEHERRSPDDRFMFALDKELQGIVEFYAPKEKEIADQYGRIKGEFETYENEYMS FT QGNNINYPTPERLQKSSASRKSGRMARSQELPRITSSNREIYLNGQTSDGGYAAPAISR FT AESTAIQPSEPHDVDTSKNGLSKKQHSEAQPEVQGNDDEVEEEDDDDDDEDEDEDEDED FT NNNNNRWLLIEQYPSDIVAYENFVSLKRKLTQLYVSIHDLISYVHLNYTGFSKILKKYD FT KTLGSSLRESYMKRVNQAYPFLPATGKTLSKRLNIVAEWYAKLCCQGDTFVAIRRLRGH FT LREYVAWERNTIWREMMAMERRTQAARLSGLKPVAADEKESEQPPYFTIKTKFGVFRIP FT RCFFNSTIATLITIIVIFILLLSFPVIDNREQNNCLALLVMVSLLWATEAIPLFVTSFL FT VPFMTVFLKILRDENGSPLSGKESTKVIFSSMWNPTIVLLLGGFTIAAALSKYHIAKRL FT ATSILAHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLLRNLPAESDFAKI FT LIVGIALASNVGGIASPISSPQNIVALQNMDPAAGWGEWFAVSIPVSLLCIFSIWFLLS FT FGLLKDEHITLAKIRSTKDTFTGVQWFISIVTIGTIVLWCLERRFDEVFGDMGVIALVP FT IIVFFGTGLLTKEDFNNFLWTVIVLAMGGVALGKVVSSSGLLELIALKIGNAVSSLNTF FT RVLLIFSALTLVVSSFISHIVAAMVVLPIVHEVGSRLADPHPRLFVLASGMMCSLAMAL FT PTSGFPNMTAIMMENEAGKRYLKVSDFLKAGIPATLISFVILLLIGTPIMRALGF" FT misc_feature 21735..21740 FT /note="gtttgt, splice donor sequence" FT misc_feature 21766..21780 FT /note="ctaattactttttag, splice branch and acceptor" FT misc_feature 21826..21831 FT /note="gtaagt, splice donor sequence" FT misc_feature 21863..21880 FT /note="ctaacaatcggtgcttag, splice branch and acceptor" FT misc_feature 21902..21907 FT /note="gtatgt, splice donor sequence" FT misc_feature 22032..22049 FT /note="ctaacatatatttttaag, splice branch and acceptor" FT CDS complement(25835..27187) FT /db_xref="GOA:O59711" FT /db_xref="SPTREMBL:O59711" FT /note="SPBC3B8.03, len:450, SIMILARITY:Saccharomyces FT cerevisiae, LYS9_YEAST, saccharopine dehydrogenase [nadp+, FT l-glutamate forming], (446 aa), fasta scores: opt: 1778, FT E():0, (58.8% identity in 447 aa)" FT /gene="SPBC3B8.03" FT /product="putative saccharopine dehydrogenase [nadp+, FT l-glutamate forming]" FT /EC_number="1.5.1.10" FT /protein_id="CAA18292.1" FT /translation="MPSILLLGSGFVAHPTLEYLSRRKENNITVACRTLSKAEAFINGI FT PNSKAIALDVNDEAALEKAVSEHDLTISLIPYTYHATVMKAAIKHGKHVCTTSYVNPKM FT AELEEAAIKAGSICMNEIGVDPGIDHLYAIKTIEEVHKAGGKIKSFLSYCGGLPAPEDS FT NNPLGYKFSWSSRGVLLALRNSAKFYENGKLVEIDGKDLMETAKPYFIYPGYAFVCYPN FT RDSTVYQERYQIPEAETIIRGTLRYQGFPEFIHCLVDMGFLDETAQEYLSPEAPALPWK FT EVTARVIKAESSSEADLIKKISSIHKFKDEDDKKRILNGLKWLGMFSSKPVTPRGNPLD FT TLCATLEELMQYEEGERDMLILQHKFEVETKEGKRQTRTCTLLDYGVPNGYTSMAKLVG FT VPCGVATQQILDGVINTPGVLAPNDMKLCGPLIDTLAKEGIRLEEEIIDEE" FT CDS join(complement(29374..29718),complement(29299..29328), FT complement(28368..29240)) FT /db_xref="GOA:P79007" FT /db_xref="SWISS-PROT:P79007" FT /note="SPBC3B8.02, len:415aa, similar eg. to YOR358W, FT HAP5_YEAST, Q02516, hap5 transcriptional activator, FT (242aa), fasta scores, opt:430, E():9e-17, (55.6% identity FT in 126 aa overlap)" FT /note="SPBC3B8.02, len:415" FT /gene="php5" FT /gene="SPBC3B8.02" FT /product="CCAAT-box binding factor subunit; required for FT growth on non-fermentable carbon sources; similar to S. FT cerevisiae HAP5; essential for DNA binding activity; FT histone fold; required for the transcriptional activation FT of cyc1" FT /protein_id="CAA18291.1" FT /translation="MNSIPDSYSLKQGFPEGLGEYVDPSGNPNSQVRIGYGQDSVSRFQ FT QPVPDVDPTAVNHYNASAPIEVASPFDNVTQGLVGSDAQALAEYWQKTIDTLEHDDQAV FT KTLHLPLARIKKVMKTDDDVKNKMISAEAPFLFAKGSEIFIAELTMRAWLHAKKNQRRT FT LQRSDIANAVSKSEMYDFLIDIISKDNNNSRASSSQAHMSATQVAAMGGMNGLQPFPTQ FT AGLPNQGFPMPTGSQLPFSNQQSSQPSMQYSSHPSRMQQMQDIDQSMYKQQRLGSEYPQ FT LQMSDNSGNVNQMNMQRPVMVAPYMAEHLYRYPPTHLESGSSAFRLQSSPMGYQMPQFQ FT GNMRPNMQQSQMFDPSAYGMSRRPGSPRQFDQQQRLYSQPNAMMYQTQQGRQGNPMHQQ FT FSQQQNPLSRYSQQPQ" FT misc_feature complement(29241..29253) FT /note="ctaatttttttag, splice branch and acceptor" FT intron complement(29241..29298) FT /note="intron confirmed by mRNA" FT misc_feature complement(29293..29298) FT /note="gtacgt, splice donor sequence" FT misc_feature complement(29329..29347) FT /note="ctaactattgattatgcag, splice branch and acceptor" FT intron complement(29329..29373) FT /note="intron confirmed by mRNA" FT misc_feature complement(29368..29373) FT /note="gtatgc, splice donor sequence" FT CDS join(31646..31852,31935..33137) FT /db_xref="GOA:O59710" FT /db_xref="SPTREMBL:O59710" FT /note="SPBC3B8.01c, len:469, SIMILARITY:Homo sapiens, FT ADRO_HUMAN, nadph:adrenodoxin oxidoreductase , (491 aa), FT fasta scores: opt: 1065, E():0, (40.4% identity in 470 aa)" FT /gene="SPBC3B8.01c" FT /product="putative nadph:adrenodoxin oxidoreductase" FT /protein_id="CAA18290.1" FT /translation="MLSRFIKRTYSTQTSSPVVGIIGSGPAAFYTAHRLLRNDPNVKID FT MFESRPVPFGLVRYGVAPDHPEVKHVEHKFSEIAESTQFRFLGNVNVGTDVSLRDLTKN FT YDCLVLAYGAAGDKRLGIPGEDLSGVYSAREVVGWYNSDPRNQNLELDLSQVEDAVVIG FT HGNVSLDVARILLSNPAQLSPTDINPLFLKSLERSNLKRLHIVGRRNIFSVSFTIKELR FT ELFALSSAVFFAPSFNYSTKWMNETDASGLDRPRKRLLKLLVSEIQKAVSEKRVAPYSK FT DKKCWNLEFGLTPVEILGHKGNVENVRFQITDSIRTDAESKFTTIPAQLFIRSIGYKSM FT PLPGMKDVGVPFDDAKGIVKNVNGFVRPGIYTSGWVKHGPIGVIATTMMDAFATADTIT FT KDWKSKKEFLKNSKLGWDGLKKNIKTPVIHWKDWKVIRNAEIERGLRHESLSEKFRSNE FT DMIKLIYPGKK" FT misc_feature 31853..31858 FT /note="gtaagt, splice donor sequence" FT misc_feature 31919..31934 FT /note="ctaacctctattgtag, splice branch and acceptor" FT misc_feature complement(33354..33398) FT /note="see SPBC13A2.01c for full length CDS" FT misc_feature 33396 FT /note="the original consensus for this base was A (ie GATC) FT but this is NOT the clone end, and end sequence, trace data FT and overlap with c13A2 showed this to be a T" XX SQ Sequence 33398 BP; 10664 A; 6009 C; 5932 G; 10793 T; 0 other; gatcctaact gacagaatta aaaaaaataa tttcaaacag tgagctagct caatattttc 60 ggcctgctcc tccacaccct aacgatcgta atcgaagacg aagaaaatca aacagactac 120 cagatataaa gattggacat ggaggtacct tagaccctct tgcttctgga gttttggtag 180 tgggattggg tacaggaaca aagcaacttt catcattact ttcatgtatg aaaacttacc 240 gagcgacagc cctgtttggc tgctcgacag atacctatga ttctgctgga aaaataatta 300 agattgctgt acacatccct actaaagagg aaatattatc tggtttagac gcttttcgag 360 gtgacatctc tcagttacct cctctttact ctgctctgca tattcaaggt aagagactat 420 atgagtatgc acgcgaagga attcctttac ctgaaagtat caaagcacga tctatgcatt 480 gcgaagaatt aattttaaaa gattttattc cgaaggaaga acacacctac acggatccgg 540 atgaatttgc ttcaaaggag gcaattgaaa gtgaggaact tttaagacct attgagggag 600 gtgccgaacg tcatgattta cttgcaaaga cagagcaaga catcaatccc caagatggtg 660 atgaaaaaat aaacgcgaag agtcccacta ccaattctgt tacagatgta gccaaagatc 720 aaactgtcac aaaccctaaa aaacgaaagt ttgaagtcac tgatttagcg cgaggatcac 780 gacctgcaat agggccaatt gcagtccttg atatgacggt ttcttctggt ttctacgttc 840 gctctttaat tcatgatttg ggccgacaag taaatagtga agcacacatg gtcgatcttg 900 tgagattgaa acaggggtct tttgcactag acgatgaaaa ctgctttgat ttttcagaat 960 tttcagctcc aggctgggag gaaaaactcg cagcagcgtt caaaatcgac ctgaaaggag 1020 acgaaacaag ctgaagcagt cttaatatat ataccagtaa tatacttttt agataaggac 1080 attcatattt tctttaaaag catataatag acatttcttt tccactccaa gcaaatatta 1140 tcactggtac agtgaagaaa acgattttta tgaagaacac tgaaaccatc aaccctttaa 1200 ttccttcaat gtagtaatac gctttaaatt tgcgtcgtgt ttcagataac tttgtagctt 1260 atctgttcta acttgtcgac cttttcctcc ataaattact ttagtaatca tatcagctgc 1320 aacacctgct gtcaagagtt tttcatctag ttttaaattt gattttttca agaagtttat 1380 ttgtctaaca gacgcgggtc tcattctcca cactgcttta cgactaataa gagaacgagg 1440 tgttttcaaa ttggaaatgt atgtttccgc tgcccttatc gcgaatttca aggaaggtat 1500 gcgatcggat acaatacgtt ttcgattata cactcgagtc cctaatttct ctttcgtata 1560 ttcagatatc ttatgtgtcc catcttcaaa atttgtatca attatcaaca ccttttgtaa 1620 aaagctcaag acatatcgac ccataccgac agcaacccaa gcattagtag ataaattgaa 1680 aatgctccta tctttgtttt taatgttatc catcatttct atcaacttcc gtaatttgct 1740 gtaccacaaa acagattgta atccataaat tttaggatca taatcagggt tcgcaaggga 1800 attctttgat ttattataaa agttttcaac ttcatcgggg gaaagaccag ctaaagtagg 1860 gtcaacatgt agactgactc ttcttaaaga atcacaaaaa tctaatatta gacaatctct 1920 ttttccctca tgcaatcgca atcccctacc aatcatctgt gtaagtaaat ttggagaact 1980 tgtaggccga gcgatcatta aacaatcaat attaggaata tcggtccctt cagtcaacac 2040 catgcaatta acaaggacag gaaatttctt ttttcggaaa tcttggatta aagtttcacg 2100 ttccgaatca ttagtttccc caaacaaagc tcgggcatca atacctaatt ttcgaaatgc 2160 attacaaact tttaatgaat gctctacatt tatgcaaaac accaatgtag atgagcggtt 2220 acctaaaagg aaattaatat agagataact atattcagct tactagcatg ttcgagccaa 2280 gctcttggaa tttcgaatat tgccttttct gattgtgcct ccttttttaa cttctcttgg 2340 tccaagaagc tagacgaatc agctaacaca agatctgtag accactttat gtttatgact 2400 tttggttcaa caagccttaa cattgggagt taggaagagt acctataaat atgacacact 2460 taccagttat ctttgatcat gtccacgaaa tgtctattta ttagcatttg aacgttctac 2520 tgttagcatt acctgtgata aacaatctca tctaggccac aagccaaccc ttttccgtct 2580 gctctgaaaa gagtcgcagt aagtcctatc acattcactt tcgatttttc cgattctgcg 2640 ccaaaatgct caaggattcg taagtacgaa ggagacgcca tatggtgaac ttcatcaaaa 2700 attaaaagtt taaaattgag aggattatat ttaagtagtc tttcattttt taaagaaaaa 2760 actgacgcaa cggtaacatc agccagtccg gatgcacact gattgcccat atcaatctca 2820 atagactatg gcaaagttag taaacgaaac agcgtggaat ctatttggaa aaagaacggt 2880 accttattcg gaaggctttc tcggcaatgc ttgagggcct gtaaagctaa ctcctttctg 2940 tgaaccaaaa ttagacattg ctcagagttt ggccttaaag taggtgcata ttttataaag 3000 tggggaaaca atgcctttag acgtgttaat attgcagtca gtagtagaac agtaataccg 3060 ttttaccaga gcctgtagct aatgaaacag caattcgacg tttaccttca tcaaaagcgt 3120 ttaagcaggc actgaggcat tcttcttgat aaggacgaag tttaagagca aatcttctaa 3180 atatagttga accatttctt ggccacaaat tctttttgca acatgcgttt agtagcatgt 3240 ctacggcaag ataatctctg acacaaaaat aattttataa ctatagaata cagcaatgga 3300 taagggcata aaatggctta gttaaaataa tttgtcagag cataaattag catgacatgc 3360 agacaattaa ttattactta cttttattga cttacaaagg ctaactaaga tataaaattt 3420 gaaagttcta taaacattat agaaaaaaaa attttaaatt ttagcaattt cataatatat 3480 gcaaataatt tactaccaac cttatgtcca agcattggta tagtatcaat aactcaagca 3540 aattattccc caagttgtaa acaaatcact tacagataaa taaatacggg tggatttaaa 3600 atccgcttct tttctttttc tttttggaag gacgagaacc atatttgcca ctaacgactt 3660 gtgacattat tgggatagtt tggctagaac tctccgagta tagcgatgaa aaattaggaa 3720 catcttcttg agaaaagact gtcgcaattt ggcttgaggg aagtacagaa gactgctgtt 3780 gtgaaatgta gaaatcacta aattggctag atgatggatc ctccgtttcg acagcgctat 3840 caccaatgac ataagttgaa gatatctttc caatctccca attctccaaa atatttctaa 3900 catcttcatt cagctccagg ccttccgtat cataaaaagg tttgataaat gtaagcaagt 3960 cggttgaatc gatttccttt cgagacaatg atggatcaaa tattttttcc ctggagactc 4020 ctatagaaga aagaaataaa tagtgaataa cattttttat agatcttctt tgagaagact 4080 gaaagcaagg aatttcgaca gacttatcag tattagattc ccagcgcctg tgtattaaac 4140 tagcaattga gtccacggaa gtataaaaga aagaagcatt gttgtagtta ataccaaaca 4200 tataaggaaa ataaaatgat agttctgtac cttctaaatg acttatgatc tcagctacat 4260 tagtaaaggt tcctttcaaa ggaaatccgt catataactc actcaaagtt attataacat 4320 cgtgattgat agaatcaaaa gcttctacaa aatccggaac tttgctagcg aattcatcaa 4380 gggtgatagt attctttttg ttcctattag agcacaaaac atggtataac cgtgacagtg 4440 ataattgttg aaaatcggaa ttcggagtgc ttattatttc ttgatcattt gccgaatcat 4500 cttcactagt gtttacagaa ggggtgatag ttttaaattt catagcaact tggctagaac 4560 cagtaagctc ctctaaatta tatattttaa gagaactttt ttcgcaaaga atatgtaagg 4620 aaagagatcc gtcagcctta tcaattattg cagaccaaaa aggtgaatca aaaggacctt 4680 gtctgtcaaa ttcagatgac tcaaaaaaat aacaaggttg tataatgagg gatcttatgg 4740 gaacctgaac ctcatttaat aatagaaatg gatgactacc tgatacaggt agagctctgt 4800 cttttgaaaa atgaatttgt tggacaacac cattcatttg agaataaaca gagacataga 4860 tgttttgaga aaaagtagcg gtaaccgtaa ttttcaaagt aggatctaat tttctattat 4920 gtttccattc aagtagcggc ttctgaggat gttgaatatc catccacaag acggactcgg 4980 tagttaaaat gaaaaactca gatttaatag gcatagattc atttaccact tgtagaatcc 5040 taacatctga actgcagtgg aataaaagat ggaaatcagg tacctcccca agagacacat 5100 gaagaataaa aaaagcatta tgcaaaatga caccgccaaa atactcttcc catttagctc 5160 tatatattgt attatcggga tttatttctt cttcgtgata agcaatggaa cttgttggtg 5220 cagaacataa tgcttgttgc aaagactctt tgaaagaact accgaagcat tccctgtacc 5280 catcatctaa gaattgccag atggtccatc taccagatga tgaagttgtt aaaaaaaatg 5340 aattatcggt gggatggaca gacacgttag caaacgagtc agaattataa acatcatctg 5400 cgtacaaaaa acgcagaggt atagcggaca agcatccagg tgtatttggc tcatctaaga 5460 acattaaatc ataagttacc tggaatataa ccaactcaca agacgataat gcgaagagca 5520 aacttggttc tccattagag aaaaccaatt gtctcactgg ttgtgagaat ttccatattg 5580 gatcctcagc aaactcaaaa gccgatacat tcaagtaaaa tgggaattct tcaaaagttg 5640 cagtattttg taatgtcgga gatgcacgaa aaatccatgg agacgagagg cataaaaaga 5700 ggagattttc cgcagtttca ttgctaatct tgctacaagc aagacattca gttgtggtgt 5760 atctgttttt atctgatggc gctgttttac ccaagcaaaa agtatttaaa atatgtggat 5820 tatatataga ctcagcagaa gaagctaatt gagactcttt cgctagtgta gaaaataaat 5880 ttcgcggaac atatctgcaa acacttaaac caaatgaact actagtcgct ttacgcgtgg 5940 aattggtggc ctcagcagga agctcagtta atttagggag tttgtagttt ggatttaaag 6000 ataagatatc ccatcttttg tccaagtcaa caagctcgac gcccgtatag gagtcatacc 6060 tagcaaaagt ccattcatta ttttcaacct tctccgctct gtgatagcca gatggattta 6120 aaagttgaca cgcccctata attccataat ccaaacttac actaggtttt ttactaattg 6180 catcaatagg ccatgttgac atgaagataa ttagaaaaat aaaattagat tgaattgtgt 6240 ttacaaaaac acatctaacg acaatacaag agcaacctag cgacaaagca agtaatcagt 6300 gtttcaagga agcaatgctg gagtaatttc acctatagtt aagaacttga ctttattgtt 6360 atactataat atatttaaag tgctatcttt aaaccattat ataattatat aaaatataac 6420 tcctaccgac tacatgcttt caattgaaca atttattgat ttatgttaac tgagaatttc 6480 tctttactag aaaaagatga agtttaaaag taatacttaa attagtcata agacagtgtt 6540 caagtaggag aggagttctt ctccgaagtc tctaagctgc tatcaattac atgtagatta 6600 acacagcaac aaaacaatct cctttacaat gaaatgcaaa cgcttacgat tttggaatga 6660 tttagcaata gataaattgg tttacgaatg ttgcattagc ccagttttcc cttttcataa 6720 aaaatacgta aggaggtgct gatacctgag gaagagtgca atattcagat tagcaagtgt 6780 tttgaattct ctttagtgtc cgcttaacca attttatcga tatgtttata attttgtaaa 6840 gtcaataagt tagttcagcc tgttatttgt aagtaattta ttgtatgcaa cgtctaaagg 6900 agcttgatac attttaacgt accattaaat atatttagac ttaaaagcat ctttcaagta 6960 atgtcaagaa acctaaaaag accgctcggc gacttacatt ctagcaaaac gttgattaaa 7020 agaatggcaa ttaagctagc ttctacaaat atttagactt ttaataaaat gaaaattaat 7080 ttttcttgca cagaaaccca tacaagtaaa gtttattagt taaaaaaaat gaaagcttct 7140 gcaatgaact ttcattttac gaacttaata aatatttaca ccgtattgtt tacatttaaa 7200 tttgttactt taaggtagtt ttgatatatc ttcttaagca ttacgtctta tgaaaatgtt 7260 attatttggg ttgtagttca tcattatata tattgtgcat cgtaccaccg tgtgattctg 7320 gctttgtttt cccacatatt ttaggtctaa ctaacacata tttaattaat tactcttttt 7380 tactaaaagg actctgcttg gtcgttgtat actttgtatg catcgcttct tttggtgaat 7440 tttttaattc tttgcaatcg cagcagagag aaaataattg taatgaattc gattgctagg 7500 ctatcagatg aaattaataa agcaatcctt gccactcctt tagacgacga tgaagctgac 7560 aaagaaaaac ttgctaatgc tcgggggcga gcttcatcag ctactttgag gcattataat 7620 cgtcgtagat cgtcttattc ggcgtccagc cttagcagtt tgtcatcaaa accgacggaa 7680 aaggaagttc ctacaaggaa tgaaaaaccg aagcatgcca acattatgcg tgttgtcgtc 7740 tactggattc gtgtgttcct gaaacgaatt tatacgtttt tcgttcattc cgctcgtgta 7800 tttttgtacc actttttgaa tgaagagaaa gagtttaccc ttgcaagttt tttttggggt 7860 ctatgccggt ttgtcttttt tcctgtatta ttatcgtata aacgccgaga gatgcttccc 7920 cctcagccaa gtgtccgccg tcctaggttt tattcttctt attcttaccc atcctctcac 7980 caggatcctg cctattcatc tttcaaacga catagatctt ctaattctta tagcagttct 8040 tctaatggaa atcatgttcg ttttcagccc tctattgcag aagaagaaat ttctttcaat 8100 tctttttcaa attcattgaa ttcagaagaa gatgtgtgtg tttctcctat gaaacccaaa 8160 gaggtctccc taatgggaaa agcaaattcc aatcgttcag gacattcgca tcaacctcaa 8220 tcaactcagt tttccccgcc tgctaatgac aatatttcta agctgccttc ctcctttacg 8280 atagttaatg atcctcttaa atctccttct tcttcccgtc tccgtattag aaacattact 8340 ctgtgtgcgg acaaaatacc gaggcctttg ttgaatagca agttaccgag aaagaccctt 8400 gtattagatt tggatgaaac acttatccat tccgtgtctc gtggtagtcg aacgacttct 8460 ggacagccaa ttgaagtaca tgtgcctggt gaacatccaa tcctttacta tattcacaaa 8520 aggcctcatc ttgactactt tttatcaaat gtgagtcaat ggtttcgcct tattttgttc 8580 acagcatctg tccagccata tgctgatcca ataattgatt atttggagcg tgataaaaaa 8640 atatttgcta aacgatacta ccgtcaacac tgtgcacttg tcgatagttc tttcgttaaa 8700 gatatttcca tttgtaatat tcatctttca cggatcatga taattgataa ttctccagcc 8760 agttacaatg ctcataaaga aaatgccata cctattgaag gttggattag cgacccctct 8820 gacgttgatt tactaaactt actttctttt cttcatgcac tgcaatatgt tcatgatgtg 8880 cgagatcttt tggggcttcg tctcgcaaaa taagtgcttt tcatgattcc tttttttttt 8940 cgtgagtaat ttactcgtta tttatcacca gtaacgatgg tctaaaataa ctttttctac 9000 tgcattaaca tcttgggtgc ctttcctttc tcatcatcaa acttctttgt tataacctca 9060 aaagggtacc ttttggatat ttcctagacc gcatttgggc cattccagtt aaataatttt 9120 tgtttctttt tgctgataat atgtcaatta atgtaagcct aatcgtaaga aattctttct 9180 aataaactaa acgcatgttt taagaaagat tagtttctgc actgatgttc gcagcaatta 9240 cgaaggcaac ttacttatga aatttctttc taaatcaagc ttttaataaa catgtttatt 9300 ctatttaagt gttgattctt ttttttttac ttttcaatct gttattacaa tcaacttact 9360 taatcaggat gggcaaagga ttataaatga tttaatgatt ataaaccaga ttacatagac 9420 ttttagcatt ttaaaatcat atcactaggc taacgacatt gttctagcaa ataacataac 9480 ccaaaaccac attattatta tatgtatcta ataacacgaa aattcaaaaa acctaatata 9540 tgcagaatta atagttgaat caataccaac caccacttct attgaagttt aatactttta 9600 actaaaccag ctttaatacc agtctgctca ccagcatagc cgccctgtgg tgcgcccttg 9660 taaatagcct ttttgctggc taatttcttc ttagcttttt cgtagcgcat acgcttttta 9720 agtcgaggat ttctattttc tttaggtcga cggggagtta atcctctatt tttagcaatg 9780 tctaaagtaa ttccacgctt atcaccttca cctaattcaa ttagttctgg gtgccttgaa 9840 gctcttatta aatcacgttc gagatcgtga ttttctttac ggagcttttt agccatcttt 9900 gattttttat cgagagactc gtaataatcc aaatcatctt gatcttcaac ttcacgatcg 9960 acatttgcag gtatgcccat tgattccgga tcttcatcat caagatcagc accagcatcc 10020 tgatttcgac ccctggctgc agcttctctc atcaatcgct gctggcgttc aaatcttcgt 10080 tctttgtatg gcatgtccaa atcacctgat aactccagta ccgctctgga acgcttagct 10140 gccttttggt caatttgatt agcataaaac tttaaagagc gtttcctagc aatcttgtct 10200 tcagcatcaa catcgtccaa tctgttgcct tcaccatagt catcgagatt tttaatatta 10260 gtattaattt tagatttagc ggctcgaaat ttcaaagtaa tatcatcatc ttcagctact 10320 ggaatatcct taatgccctc attttcatta tcgctgattg attcgtgcat atcaacatct 10380 tcttcatctt cggacgcacc aatgtcagat gccgatgcta tcttttcgtg aagctcgata 10440 gtttttccat cttcctcgag agaagttgga gtcaatactt catctaaccc acaataagac 10500 tcccacgtct gtttgcaacg aacaaggtca accataatag gatgattttt taaatcttcc 10560 tctccatctt tcaagagggc aaagtagaat gttagaaaac tgatgtaagt actcagagcg 10620 gtgcattgag cttgaagtag ctgagaagat ggataagtct taagtttctc cttaatttca 10680 tttaactggg gtttcaattg atttaattca tctaaaaata attgaaattc aggatgttta 10740 gcttctagaa tctttaaaag ctctgtacga gggagatcag gtgaaatttg ctgaacaagt 10800 tcttcaattg cagcagcaga ggaatcctgt tttatagatt ttaggtcact gttatcagcc 10860 cattgactaa tatcatcaat agcatcagtt tcgctgactt tttcaagacg tttacgttgt 10920 aaacgcaacg cttcttgctc ttccattcgt gcgtcaaatt catcgtcctc ctcagagtag 10980 tcttcattgt cataatcatc cccaccgtaa tatgattttg cagagcgacc ccaaccttta 11040 ttatcatata actcttcctc attaacagcg tctttctttt tgcccgagag ctcttcattt 11100 tctgataaat tctcctcggc gttcccatct tcctcatcgc tagaactttc taaagccaca 11160 agttcttcat cacttaattc taattcgtct gcttgctcgc cgttgtcagc atcaaacaaa 11220 attttatcct gtgcgttata gaattcatct tctgaattag caacatcttc gtatgtattg 11280 attgcgttta tcttttcttt ctcctttatt tctggtacct ttaaagaaga acctttccga 11340 gtagaagagc ttctcgactt ctttctagcc atactgatat gcagttgaca aatataaaaa 11400 ttctttttag ttacgaggag ccactaaagg ggtaggcaag ttttatttgc gaatttaacg 11460 caataaaaac ttaattttgt taaaaataaa gcaactcatt attccacact attattttca 11520 tggacttctc cgtacataag aaagttaatt agaggtgttt tctttccaag aataagtatt 11580 tacatatcaa attcttttaa aatcattaca tgtataattt tcgatgcaca caattatgtg 11640 agatgcatgg ttcatgttga caaactctcc taatgtcata gttgccagtt gttttgaagt 11700 tatgcggttt attgaaacag acttaaagga cttaactcgt ttgcaaatct cgtatttctt 11760 ttaaataatt gatattcacc gaagtcaatt accctgtaat tatagatgac ttgtaattgt 11820 ttacaaaaac acctaagacg acattagcga ttttgcaagt gaaatcaaat ttaaaatacg 11880 ttcaattctt tgtaatgata cgtcaaggaa ttcagtattg tgtggtagag gaagacgatc 11940 gtcaagctga ctttccaact ctgaaataag cctcgagtag acgcttaaag tggcttgatg 12000 gcttgattca gttctttcca taactggcgc ctttgttgtt tgctgtgatc tttccgcatc 12060 atttgtttta gatataggta aggaagctat ctttggagca gattcagcga ctgttacatg 12120 ttcagaggca tcagattcct ttaggtcgtt tatacatgaa acacaaaaca tagggttgtc 12180 acgaagtcgc atcataggta cctagaatag tgttagaaaa agggtaatag taaaattggt 12240 tttgttttaa aaaccaaggt agcaaaagca ttttgagaaa agaaaactga cttccttaat 12300 atcattccgt ttgccattgt attcacctga agtttaaaca acgactaaat acaaaattaa 12360 ttaccttttc acatttcgga caaatggtat ccaagagagt atagccgcgg agcatatatt 12420 gacccagttg agcggagacc tcgtcttgtg ttaacatttt tctaaagaca gtagtgttat 12480 agaaccgatt tatacaaaaa taagaagtgt ttgtatattt tatgttctga gttatttccc 12540 tacttgttag aaaattttag ttttgacgaa aatgctgtag gttgtctgta aagagactat 12600 gagcgtaggt tgaatcgaag aactaaagaa agacaaaaaa tttatgtata tataataaac 12660 agagttatat aaaaaaaaac gctgcactga aagttttgga gtttgaaaac tgaacttttg 12720 atttctttaa tggtgtgtgc aagtactaat cgctgctaca gtacaatgat ttgaaaaact 12780 agggtaaatt aattaaaaaa aacgatatat ggaacccata caattttttt attttttaaa 12840 gtctaaatct ttcctttatt taatataatc ccttttctca cttgatttta tttcacttgt 12900 tctaactttt accctatttt tttagtataa aagttaatgg caaaacaaaa atgcgttttc 12960 gaatgaaagc tgtgaatgtt agtaagagca ccattaatgg gggtttgctg taattctccg 13020 aaacacgatg taataatgta tctaataatt cctctataac tcattttttc taaagtcacg 13080 ggtattagtg taacagacta acgtcacaaa taatttaaaa aaaaaaagaa aaaagaaaaa 13140 aaaaaatgaa acaatgaacg agcttcgtaa gaaaattcga tgaaatatat ttattgttaa 13200 ttagatgata taataaaaat aaaataaaat aatatatatt cgagctgaat tgattacatc 13260 aaataccaaa atattaatag gaataaaaaa caaaataatt acataaaatt attcatcaag 13320 ttgctacttt ctctcatgat gatttaaatt aagtagagta cttgttaatt aagtatgttg 13380 cacaaattag cataatagat gatggtgttt atttatttca tagtcggtgc aaataacaat 13440 catctcaaaa agataggttt attggaaacc cgcttcaggt ttcgttttca tattaatatc 13500 ataaggttgg taaatttagc ggattgacaa aaaaggtaaa ctttttcgta aatttagaga 13560 aatacaatca tgtttttttc aaccaagcaa ttgttttata gattaattta actcttttta 13620 gatacataga cccccaaatg ctttacccaa tgaacaaaag aatattacaa agcgacagtt 13680 tttttttatt tactaaggaa catagacggt ttgccttgtt tactgatttc ggaggctaga 13740 caaatggtaa cgaaggtttg gcggaatttc aatacgtata tgttacaagt agtaaatttt 13800 acttttgaaa ttgctaaaaa agcggaaagt tttcccgatc atttcccgta cggcatgttg 13860 gaatttgagc attgaaattt caaagcaacc ctaattgttc cttacccctt tttcctttcc 13920 gttcctgctt actgcagatg cgaaggaaaa acttgtgtac aaagactagc gataagataa 13980 aaacttgatt gaaaaaagaa taaacaaaag aaaatctcga cagtcaaggg gagatggcat 14040 agaacgggat tattaagaag ctatttagat gatgggtatt cggaccaaac ttctttgtat 14100 attatacata caacttgtgc aaagttgagg aaaattgtta ttattctttt tttttttttt 14160 ttttttttat atttattatt ttccattaac ttcgttttcg tactaataag tattcaaatg 14220 gaaagctttt cttttaaaca tatttctcac cattcgtatt ttccaatgct tcctttgtaa 14280 aatgtaaata aataaattaa tagatatttt ttaggaaaca aatgtattca tcatagttta 14340 atttatttat ttattttcaa aatttatttt attttatttt ttttttattt actatattcc 14400 gtctcatgta acttcactaa agttcattta atttatacta attcattcag ttcatcccat 14460 ctcaccgtat atgttgtatt actttccata gccactatta ctattattct ttacttacat 14520 acccaacatt acctcttccc cccccgtagt actcatttcc cccacctcat taactcctaa 14580 gtcttagtct agctaaccat ctccatctac ctttgcttta cccatgatac cctttttcgt 14640 accttgtggg gggatccgat atcgacctca ctagtgtgcc acacccacat cttttacatt 14700 cggtatgcgc ggaaccatat gattgtgtcc acttctttcc aacatgagta ttttaaaccg 14760 ttagcatgat gtagcttttt gtcacttaaa gtgaaagctt tgccgcccct tccgtcgtct 14820 ggtacacgct tctttgcttt aaaaagaatg agtggtctta tatatacgag ttagctgtta 14880 aggcattggt taacgagctt aactaccaaa agagatagaa gcaaaaaatt gtttgaattt 14940 gccgataccg ttagttgtag tgcaaatcat ttcgttggag aagttattgt ataaccagtc 15000 ggtcatacat acatcgccaa gaacgcaatc cacctttttg ccaacctaac gtagaggatc 15060 gtaacaaacg ttgcctttga agtgaattct aagcatttgc cgaaaaaatt tgcttcgttc 15120 tgtctttcta ctaccctatt cggattttgc aacagttgcg taaggaagca aaatttcgtg 15180 tgtgttaagt acttaattgc acccaactaa ttgacccgct ttttttttca acatacacca 15240 ctagctgtat tgaaaagcaa cgcattgttt ggaattctac agagattaag ctgatttttc 15300 tgtgccaatc gaatttgtca gctaaataga atttcctttc atagacttat tgttcttctc 15360 tttaagcttg tcttttcttt acggtttttt gcctagtgtt tgaacaagtc caattgcgcc 15420 ttagttcgta gctagcttaa ctgtccttgc tttgttatcc gtttattaca aggtttacga 15480 aacgttgccg cttttcatct ttcagccact cgcctaaatt gcgttattcc tgagatttgt 15540 ttacgagccc agctccttgt cactttccga aacttgtgtg ctgtatatta cttggcctct 15600 tcctctatcc tgaatagcca agtatctttc aatagctatt gtttccctag ttctatacgt 15660 gagctttttg aaatttacat aaagctctcg gtgactagat ttaacatatc aatctaacca 15720 gattatatat atttttttgt ttgttagaac aagttgttga tacatctggt ttagaaccct 15780 caataatact ttgttaagtt tcttgttgtt gtgtctttta taaaacataa ttacttgcat 15840 tgtttcattt ttcgttaagc atctctttag aaacgaaaca tggccgaatc aactgctaca 15900 actaccgctg ttccacctcc agcagaagag tcttggaatg ctgatagtga agatgttcat 15960 caattttact ggacatacac ggaagagcct cataaaagtc gtcgtgctgc tattttgaag 16020 gcccatcctg agatcgcctc tctcaatggt tatgaacctt tgaccaagtg gattgttctc 16080 ggcgtggtgt ctctccaatt cacatgtgct tacttgcttt cacaaagttc actactgagt 16140 tggaaattct ttttaactgc ctactttatt ggtgcctttt gcaaccaaaa tctcttttta 16200 gccattcacg agttgagtca caaccttggt tttaaaaaaa ctctttacaa tcgtgcttat 16260 tgtttgtttg ctaatttacc tgtaggtgct ccttttgctg caagctttcg gccctatcat 16320 atggaacatc atgcctatca aggtgttgat ggtatggaca ctgatttgcc cactcgtgcc 16380 gaacttattt tatttgataa tgtgcttgga aaggcatttt tttgcacttt ccagctttta 16440 ttctacgcat tccgtcccct tgttgttcgc cgtcttcctt tcactttaat gcacttttgg 16500 aatattatcg ttcagttttc cttcgattat ttagttgtgc gatatgttgg atggagagca 16560 ttagcctatt tctttatgag ttctttctta gccggtagct tgcatccaac tgctggtcat 16620 ttcttaagtg aacattacaa catgacccgc acccgtctta ttgcctccgg tcctggtaag 16680 gaaacacctt tggagacctt tagttattac ggacctctca acttctttgt ttataatgct 16740 ggttatcata ttgaacatca cgactttccc tatgttgcat ggactcgcat tggcaaagtg 16800 cgcgaattag ctcctgagtt ttatgacaac attcctgact gtaagagttg gtgcggtatc 16860 atttatcaat tcatcactga ttcaaatgtt ggtatgtggt gccgagttaa gcgtaagcaa 16920 aaacatgctg atattccaac taaatcaatg caccttcatg tttcataaat atgatgatga 16980 ttgggtttcg gttatttcat ttaaattcta cttcttcatt tttgatttat ttttttcgtt 17040 cagcgtagtg gtgctactta ttcatctaat tcgactgcac agattgaaaa ttaacttaat 17100 cacttgaggc gtgtttcact taatattttt aataattgat cactactttt ctattaaata 17160 ctattgctgt caaatttttt tttaattgct tcattattca tatgtaataa attactttgg 17220 ctatgcaaac ggtaatgttc taaaacacat aaaaacgaaa aaataaaaac gttagcaaaa 17280 ttacgacaaa aaccaaattt ctttatcttg taagttaaag tagctggcat atattattat 17340 agaaagtatt aaaaaactta tacctaacgc aacagtcaaa cagaaatcta aaaaataaga 17400 attctaaaaa aaaccaaaaa aaataacaaa cacaaatgac caataaagta cttcattagc 17460 cattgcttta aaataatcta tttagaacca aaaaagttat cttgaactag cataaccttt 17520 gagtattagg aacattactt cgagccccat aacaatacaa gtaaacgcga cagagatgtt 17580 cataataagc attggtgaca tttcgttcaa gcgaattttg ttgacaacat cataagatga 17640 agccataaac atagcaccac cacaaataag acagaaactg gtaattattt cagtaggtgg 17700 acgagtaggc cagggagagg agggaggttt caagtatagc ataatatatg tacagatacg 17760 tgctatagct gccgcagcta ataatcttcc ccataggaca tgaatgacgg tcgagacatg 17820 attggtttgg tcatgtgcag acatcataat accggtgaaa aatactgtaa gagcaggaaa 17880 cacattgtat gagggtaagc cattctccga atgctctgaa tcttcagagc gacgctgacc 17940 aagtgtagct gataaagtag catttaacaa ccggtggaca actttagatt ctacaagaat 18000 accacacaga ccggcccacc aaagcatgaa tgctaatgat gcatgttgca aatcgtgatg 18060 attccatttt ccatcagtat ttcccaaatg ctccagccaa acatttgaga caccataagc 18120 aaagagcaaa aatgactcta ccatttcttt agtgggtaca tacttagcaa atcttttttc 18180 agaaagttgc ttgggaacaa cattccaagc ccaaccgtac tcggagaaag cacctaaata 18240 ttcaccaaag gacaagatgc cgtaccaaag aaatatggcg cccttaatcc aatgagccaa 18300 accattgaaa atatgttgtc ctttaaaaat tccagctaac aaaacaattc ctgtacagct 18360 ttcaaaaaag ccaacatata accataagtg acctaaaatt ctatggaaat aacgaagaac 18420 ctggaggaca caccattttt taggaattgt acgccatgac ctaatattta tgaaggagat 18480 acttgggatt gatggttttt cagatgatac gtcgcgacgg gatgattgag gtggaagata 18540 ttcatcagaa gaattaccct ctcttggtaa taaaggtgca ccgtcatcta aactatttct 18600 ttgaagggct tgctcaggat cctccatcgc acctggagcc tcggcagcag gttggtactc 18660 cttcaacatt cgtttcttta atatagaagt tgtaatgcct actattgcta tcaagaaagt 18720 aatccacatg aaaaatcgtc ctacaggtcg atgaatattt cctttgtaat aattttcagg 18780 cgatgctttg tgatgactta tatgagcaaa aatataccca ataagggtca aaataacata 18840 tacaatttgt acgggtatat gtgctttact tttcgccata gcgagtacaa ttccagcagg 18900 aaggataaat acataagcaa ttatcatgca aatgatatga gccataagaa atttgttcat 18960 gtgatttgca taattttcga aatcaatttc gatgggatta tctcccgtgg aattcatgtg 19020 cattccatcc attttttcgc ttttttttgc aaaatgttca gaaaaaagtt aactaattgg 19080 tgccaaaatt aattttggaa gaaaaaaatt tgttcaaatc aaataaaagg gaaaaccgag 19140 ttgggttagc agctctactt tattcctttt tcttttatat ttataaatta aaccctgaaa 19200 actgagttcc ttaaagcatc aaacgcatga actattagtt agttcacttc tggcttcaat 19260 tggaactttt agaatctaaa aagagttaat aacacttctg ccatcatcga tatatatgca 19320 aatcaagtgg agtgattttt gcgcagacat atccgctccg gtatcatagc atgaaattct 19380 ctcatcaaaa tgtgttaact tgtaatatga tgctattaac ctaccttttt attatatata 19440 agtatatata acaacactat tagaagggag aaaaagggat tcactttgag aatgggttat 19500 gggagtgttt aagctgaatc ggacggtgac ggagtgataa cgatcaagaa cattcctatt 19560 ggcttacttg gctaagcatc ctgaacctat ctgcagctac tagaactact cacataaaaa 19620 aagttagaac aacataacaa gaaaaaaatt tcgcattgct tgtgttgatt ttataaccgc 19680 catggaacag gggggtatgc tggacacatt caatcgttac tttacaacat gtagggctgg 19740 ttacttataa atttccttaa aatgagggac gcgcctgccg gtgcatagtt taaatataaa 19800 tatattaaag cagtagttta tgtaatacat attgtattta tcagatgaga attctattgg 19860 tattttaata aacctataaa gaacaatata agggttaaaa aataacaagt attagtgcca 19920 ttaatggcaa gtagcgttaa gaagaaacgg gtccggtttt tttgcgattt ggcagaggtc 19980 gattttcggg attatttgga gtccaattac ctaatgaatt ggtagcgtaa aagtccatag 20040 gataaacttc cttccaagga acaacattaa aagcagcaga tgcttcatat ggtgtcaaca 20100 atggagcggg aaatgcatag ccccaatcta tggaaagcct tggacaagcg acctgaatcc 20160 acgcgtcaat atcagagaat tgacccaatc tactaggaaa aatttctgac attaaaacgc 20220 aaacgaaatc tttattattt ttccttaaag tattctttaa attttcgagt accttaggag 20280 acccctgtcg acccagtgta ccttgaatta gaccgaactt tttagcggta cgagctttct 20340 caacggcgga ataccgaata gatttcattt cttcatgagc ataagattca atagagagct 20400 tatgtgagta aggatcatag cggtatgcgg gcaaatcagg attagcaatc atgacagatt 20460 ccaaatggaa tcttccgtca ccaatgtaaa ttaatgcatc tacagatcct ttttcaatat 20520 agggagatgt acatcccaac gcctctccag gagataatgg ctttgcttgt ggaataacaa 20580 cgtaaaaacc tccctttccg tcttcatcct gtatttgcaa agcgtctttt atagagttga 20640 gagatccaac aaattggata gttccaacca aagctaacct agaattggag ggtagattat 20700 gttttaaaga tgatacgaca tgttgcaaat ctatctttat atccacgaaa acatatagca 20760 cctttatggg cgtttgatca acaggtataa gacaagaatg accatagtgt actaaaaaat 20820 cgcaatcgag tgccctagct gtaaaatcgt caatacaaca cgcaccgtat gtaacgtcgc 20880 ccatcacaat tgtctcgacc tggcaaaatt gttcaaaaat atcagacaat atacaaccaa 20940 acatcaatag cccctcggga agttgcaagg caacacgttt tgcttttcgt aagcgaatat 21000 gccaaatggt tttgtgaatt tcaaaattgt aattttgcgg taactattaa aggttagctg 21060 accaagcttt gatgtttttg agaaaagaag aaactaattt acggcatctt tctctaataa 21120 aagcagctta ccaattttat agcttcatta attgctttat cgtttaatat atcctctggg 21180 atttgagtag ctactcgtcc agcgctcctc ttggagttaa tagtgacgag agcagcattt 21240 tcaacatctc tattagaacc atccaaatta ttttccttcc tatttttttt gccaacaaaa 21300 cgacgttttg gaattgattt tttcacttcc gccattgtgt tttaaaatta taaagtctat 21360 tactaaaacc ctttgaaatc ccaagaagta accaatgcta tgtatgtatt taaattgata 21420 gaatgccaaa aatccttttt ccctgcaaat tgcttgtttg ttaaattaaa atacaatagg 21480 atcccaaata atttactaag taaaaaagca ttgcactttg ctatattatt taacacacgt 21540 tgttatatta cgctatttct atcggaggtt ggatccacga atacagcttc acctccgatc 21600 ataggccacg aaatttgaac ggctaacgct cctttagatt gttccaaatt aatttgcgtg 21660 aataagctaa agctgttttt agtcacaatt gaagttaaat gacctctgtc atccaagatg 21720 aaattcagtc ataggtttgt tgcatcagtt ttcacaagac ttgttctaat tactttttag 21780 tcttcaattt aatgcagtac cggaatggtc cgaaagctac attgcgtaag taaacaacct 21840 gttggattac ttccgatttt tgctaacaat cggtgcttag ttactcgaac cttaagaagc 21900 tgtatgtttg aaaattctcg agcttacgac tggctattat gatatatcct atattccgac 21960 aaattcatac ttgcgaaatt tgggataatg tctgattaac agccggagaa taaaattgta 22020 cttgaatttt gctaacatat atttttaagt atttattcat tggaacatga acagataaca 22080 ttacaacaag gcgctccaga tgaagaaact aggctgttag agcacgaaag aagatcaccc 22140 gatgatcgct ttatgtttgc tttagacaag gaattacaag gaattgttga attttatgct 22200 cctaaagaaa aagaaattgc tgatcagtat ggtagaatta agggcgaatt tgaaacctat 22260 gagaatgagt atatgagtca gggaaacaac attaattacc ctacccctga acgattacaa 22320 aagagctcag cgagtaggaa atctggtcgt atggcccgca gccaagaatt gcctcgcatt 22380 acttcttcaa accgtgagat atatctcaat gggcaaacta gtgatggagg ttatgcggcc 22440 cctgctatat ctagagcaga atctactgct attcaaccgt ctgaacctca tgatgtcgat 22500 acttctaaaa acggtttatc aaaaaaacaa cattcagaag ctcaacctga ggtacaaggc 22560 aatgatgatg aggtggagga ggaagatgat gatgatgatg atgaagatga ggacgaagat 22620 gaagacgaag ataacaacaa taacaatcga tggttgctta ttgaacaata tccatctgat 22680 attgttgcgt acgaaaactt cgtttcttta aagcgaaaac tgacacagtt gtatgtttca 22740 attcatgact tgatttcgta cgtccatctt aattatactg gtttttcaaa aatcttaaaa 22800 aaatatgata aaactttggg tagtagcctt cgtgaatcgt acatgaagcg cgtcaaccaa 22860 gcttaccctt tccttcctgc tactgggaaa acattgtcaa agcgtttaaa tattgttgca 22920 gagtggtatg ctaagctatg ctgtcaaggc gatacatttg tggctatccg tcgccttcgt 22980 ggtcatcttc gtgaatacgt tgcatgggaa aggaacacta tttggcgtga aatgatggct 23040 atggagcgtc gtactcaggc cgcgagatta tcaggactga agcctgtcgc agctgatgag 23100 aaagaatcag aacagccccc ctattttaca atcaaaacta aatttggtgt ttttagaatc 23160 ccaagatgct tctttaatag cacgattgca actttaatta ctattatcgt tatatttatt 23220 ctcttattaa gttttcctgt catagataat agggaacaga acaattgttt ggctttgtta 23280 gtaatggttt ctttattatg ggctacggag gctattcctt tgttcgttac ttcgtttttg 23340 gttcctttta tgactgtgtt tttgaaaatt ttgagagatg agaacggttc acctctttct 23400 ggaaaggaat caacaaaggt tatatttagt tcgatgtgga atccaactat agttttgctt 23460 ttaggaggtt ttaccattgc agctgctcta agcaaatatc atattgctaa aaggttggcg 23520 acttccattt tagcgcatgc agggcgtaag cctagaagcg tgcttcttac aaacatgttc 23580 gttgccatgt ttgctagtat gtggattagc aacgttgctg cgccagtgtt gtgtttttct 23640 attattcagc cccttctgag aaatttacca gcagagtccg attttgcaaa gatactaatt 23700 gtgggtattg ctttggcatc taatgttgga ggtattgctt cgcctatttc atccccacaa 23760 aatattgttg cgctacagaa tatggatccc gctgcgggat ggggtgaatg gtttgccgtc 23820 agtattcctg tatcgttact gtgtatattt tctatatggt ttctgttgtc ttttggatta 23880 ctgaaagatg agcacatcac tttagctaaa attcgctcca ccaaggatac atttactggt 23940 gtccaatggt ttatttccat tgttacgatt ggtactatag tcctttggtg ccttgaacgc 24000 cgcttcgatg aggtgtttgg tgatatgggt gttattgcat tagtcccaat cattgtattc 24060 ttcggaacag gtttgttaac caaggaggat tttaataatt ttttgtggac agtcatagtt 24120 ttggcaatgg gaggtgttgc gttaggaaaa gtagtgtctt cttccggcct tttagaactt 24180 attgccctta aaataggtaa tgctgtttct tcccttaata catttagggt actgcttatt 24240 ttttctgctt tgactcttgt tgtttcttca tttatttctc atatagtagc tgcaatggtg 24300 gtacttccca ttgtccatga agttggaagt cgccttgccg atcctcatcc acgtcttttc 24360 gttttggctt cgggaatgat gtgtagtctt gctatggctt tgccaaccag tggttttcct 24420 aatatgacag ctatcatgat ggaaaatgaa gctggcaaaa gatatttgaa agttagtgac 24480 tttttaaaag ctggtattcc tgccacacta atttccttcg tgattctcct attaattgga 24540 acaccaatca tgcgagcact tggattttaa cctcctaatt tgtaaacggt actgtatctt 24600 tctttttata atttttgagt cgaagcatgt tctgctgcat aacacattca tatttgtcaa 24660 ttctacttaa atagatttta aatcattgca ttcgaagata aaattatggt agcttagtgt 24720 tcctacggat cttaatgtat ttatatgttc actttataat acgatacaaa acaaatttta 24780 tctctccttt gtttcaaatt gactggcaaa aaaaaataac aaataactaa tcacaaaaac 24840 ctaaggaata tgaaaaatag ttgctaattt tcgtagaaac ttggatcttg attagaaatg 24900 aaccaaatta tgcatcattc aaatagattg tagtgtgtat ggtgcagcgg gaacgttata 24960 attaaccatc acctatagtc tcaaaatgtt acgcaaattg cccatcaatt ttgcgaaatg 25020 gactgtaaaa aaggtgccag ttcagcagaa aagatttaat agtcaacaaa aagaaatctc 25080 acctcatgta agcttttcta aatacgcttt aggtcataaa ttttatctgt gctaaaattc 25140 attcaagcat ttttgcattg ttttatttaa cattatttta ttaacgatca taaagattat 25200 gttttataaa aactacgcta gacctcttgg taaagtgacg ctttttgcct tagcaactta 25260 ttatggattg gaaatagttt ggtggaaatt agatgcatca gaacaggaag ctattaaaaa 25320 cagtaagttg ttgatatgtg aaagctcttt tagtttgttg acatttaggc gaattacgga 25380 atttagagaa tgcgaaataa aaacacgaga tttgtatgac ccagaaattt agtaacgtat 25440 atggcttaaa gaagcgagat tacgatttgt taatagttca gtatgtcaaa aattctttga 25500 atagctaaat gctacagacg aaacactcag tcaaaaggtc ctcgagttgt ttgttcaaat 25560 aatcgagaag aggttatttt ttcttcgagt tttacgtcgg ttacctaaga ctaaatacat 25620 ctacttagaa aatacgaaaa ccccaagtaa agcttcacat aaataaggtt gcaaaacaaa 25680 ctgaacattt atacttatga acatgtagat aaattgccaa aaaaaaggtt gacgaactct 25740 aagattacga ataattatag aaaatgaaga agctttggtg ttctaaaatg tcaaacttat 25800 atataagagt ttggaaccaa agcgtgaaac atgcttactc ttcgtcaata atttcttcct 25860 ccaatcgaat accttctttg gcaagtgtat caatcaatgg accgcaaagc ttcatatcat 25920 taggagccaa aacacctggg gtgttaataa caccatcaag aatttgctga gtagcaacac 25980 cacaaggaac gccgactaat tttgccatag aggtgtagcc attaggaaca ccgtagtcaa 26040 gcaaagtgca agtacgagtt tggcgttttc cttctttggt ttcaacttca aacttgtgtt 26100 gaaggattaa catatcacgt tcaccttctt cgtattgcat aagttcctcc aaggtagcgc 26160 ataaggtgtc caaaggatta ccacgaggag taacgggttt gctagagaac ataccaagcc 26220 acttcaaacc attcaaaatg cgcttcttgt cgtcttcatc tttgaatttg tggatggaag 26280 aaattttctt gattaggtcg gcttcggagg aagattcagc cttgatgaca cgagcagtaa 26340 cctccttcca aggcaaagcg ggtgcttcag gagataagta ttcctgagct gtctcatcca 26400 aaaatcccat atcaaccaaa caatgaataa actcgggaaa tccttggtaa cgtaaagtac 26460 cgcgaatgat agtttctgct tcaggtattt gatagcgctc ttggtagaca gtggaatcac 26520 gattaggata acaaacgaaa gcgtaaccgg gatagatgaa atagggttta gcagtttcca 26580 tcaaatcctt gccgtcaatt tcaacaagtt tgccgttttc ataaaacttg gcagagttgc 26640 gaagagccaa caaaacacca cgagaagacc aagaaaactt gtatcctaaa ggattgttgg 26700 agtcctcggg agcgggaaga cctccacaat aagacaagaa agacttaatc ttaccgccag 26760 ctttatgaac ctcttcaatg gtcttgatag catataaatg atcaataccg ggatcgacgc 26820 cgatttcgtt catacaaata gaaccagcct tgatggcagc ttcctccaac tcagccattt 26880 tgggattcac ataactggtg gtacaaacgt gtttaccatg cttaatggca gctttcataa 26940 ctgttgcatg ataagtgtaa ggaatcaagc tgatggtaag atcatgttcg gaaacagctt 27000 tctcaagagc tgcttcatca ttgacatcca aagcaatggc tttgctgttt gggataccat 27060 taataaatgc ttcagcctta gaaagagttc tgcatgctac ggttatatta ttttctttac 27120 gacgagataa atattctaaa gtaggatgag cgacaaatcc cgaaccaagt aataagatgg 27180 aaggcatttt gatgttgaaa atgaaagagg cagtcagtta aggacaagtg gtaaaccaaa 27240 gacttctgtt ttgtcgtcac ggttttagcg atatataagg ggttcctttt tatccacaga 27300 tttatttctg atggccgaaa tcgtcgtcta aattgatgaa aactgattat ctcgaatcgg 27360 ttaaaaaagc agtcacatgg accatttttt gaattaatat ttaatcgtta cgtttcctct 27420 caatgttatg tttggcttac taggggaatt cgttattatc gacaagttta gtcgataatt 27480 tgttagcagc gatgtcgcaa ctgatagttt tagcaacttt ttttacgtag tttttttctg 27540 cagaacagaa gttgcttaaa agctagtaga tgccattcgt tgttgtttgg gggtagatta 27600 aagaattcta agctttagta taagaataat ttgtttctcc tctttctgcc tatctgttgt 27660 tcataatcaa ctgcgtagtt ctggtgaagg agtaaattaa actgcctcgc accgccgtac 27720 tcatttttac ctcgagtatg gtggccgtgg aatggtggtt ttttatgcag tcgggaatga 27780 aagcagctgt aatttccttg cataatgagc ctaaatacct ttttacatag aagttaaaat 27840 ttatgagatt ttaaattaaa aaatcatcaa aagtgcaaat tttcaagtac atatacgaat 27900 aaatttaatt ataaagtaaa cctaaacgtt gtttaaagct aattgcttct tggtaaccga 27960 ttgcaacatg ccatcattta tttacattga caacccgtaa atatccataa taggtagaat 28020 gttatcgaca atgaatttca aatgcatata tatgtttaag taaaacaaaa tactctacac 28080 tagcagtccc gcaatgggaa aataaagagg cagcaaatat gaaaagcttc cgtcatttct 28140 ttttcggtct tgctaaaaaa ataaaaccac acatagctta aaaaaagtaa caatgactag 28200 acatagcatg tcatgaaaat caactgtttc tttaagcttt tgtagataaa ccgaaaattg 28260 acaaattgaa agttccacct aaaaatgcat cactgttgga tcctcccaaa taatttaata 28320 gaaattattt aaattgcatg ttctaaatca acaggtatta aaagatatta ctggggttgt 28380 tgcgaatagc gagaaagagg gttttgttgc tgggaaaact gctgatgcat tgggtttccc 28440 tgacgccctt gctgagtttg atacatcata gcgtttggct gtgaataaag tctctgttgc 28500 tgatcgaatt gccgaggaga tccaggtctt cttgacatac catatgcaga aggatcaaac 28560 atttgagact gttgcatatt aggtcgcata ttaccttgaa attggggcat ttgatatccc 28620 ataggggatg actgcaatcg gaaagctgag gatccagatt cgagatgcgt aggtggataa 28680 cggtataaat gctcagccat gtacggtgct accatgaccg gtctttgcat attcatctgg 28740 ttaacatttc cggagttatc tgacatttgt agttgtggat attcagagcc cagacgctgc 28800 tgtttataca tagattgatc aatatcttgc atttgctgca ttctggatgg atgagaggaa 28860 tactgcattg aaggctgact tgactgttga tttgaaaatg gaagttgact accagttggc 28920 attggaaacc cttgattggg taagccagct tgagtgggga aaggttgtaa accattcata 28980 ccacccatag cagcaacttg agtagcagac atatgagctt gactggaaga tgcgcgggaa 29040 ttattgttat ctttagatat aatatcaatt aagaaatcat acatttcaga ttttgatact 29100 gcatttgcaa tatcggatct ttgtagtgtc cttcgttgat tttttttggc atgaagccaa 29160 gccctcatag taagctctgc aataaatatc tcacttcctt tagcgaacag aaaaggagct 29220 tctgccgaga tcattttatt ctaaaaaaat tagtaaaagt taatgtcaaa aagtattcga 29280 atactcaaag taacgtacct tcacatcatc gtcagttttc ataactttct gcataatcaa 29340 tagttagtaa ttaattcaga aaaagtggca taccttaata cgagctaagg gaagatgcag 29400 agtttttaca gcttgatcgt catgttccaa tgtatcgatg gttttttgcc aatattcagc 29460 aagggcttgt gcatcactgc caacaagacc ttgagtaaca ttatcaaatg gactagcaac 29520 ctcaatgggt gcactagcgt tgtagtgatt gacagcagtt ggatcaacat cggggactgg 29580 ttgttggaag cgagaaacag aatcttgacc ataacctatc cgtacctgag aattaggatt 29640 gccagaggga tcaacatatt ctcctaaacc ttcgggaaag ccttgtttca aggaatagga 29700 atcaggaata gaattcattt tgcaatgaat cttaattgaa aaacgaaaaa aagtctacag 29760 aaaggcaatt tagtttaaaa agaaaactgg aaacgtaaag gcctttgcca attagataag 29820 agatcaatgc aatctcactg gtgacaggtt taaaaaaacg acaatgacaa aaattgtaac 29880 tatgccggga tctaacaaat accagtttcc taaaaacaaa gctgttaaag aaactgacaa 29940 taatttaagc taaagaattt caaatcgaaa atctaaatat taagaggcga taaagatgcg 30000 gattaaagaa aacttccaat accttgatgt acagcttaac aaaatcgtaa ccaagataag 30060 tagaaataaa atagaaaggg agcggagtag tctccggtaa aatggggaat taaacttata 30120 tgagaggtga gcaggagacg aaacagggaa gtaaaacaaa ttgacgtcaa gttgaagagt 30180 ggaacggaaa gaaaaaaata aaaagtttta caatcgaaag gaacacgaac ggctaaacac 30240 gaggcttagt tgcaatatct aaaaagataa ataccaatcg tcttaattca cgaaaaactc 30300 gtagaatgag taagacaaag caacaagtgc agttactaac gtatctctaa cacattaact 30360 tcttaaaaca aagaacttca ataaagaaca ctagtaaagc accttaactc gtcgaagtgt 30420 cttgaattat ctatgtagcg tattacacct ggcttaatta agtatataga gtgcaaaaac 30480 actcaatata gcgaaaatcg gtacgattga atttattggt ggctggcaga agatggttgg 30540 ctgtcacaca acttattgat ggaaccggtt tatagtacca catactttgt ttctacaatt 30600 gctaaaacac tttaacgaca cgtaaatatt cattatttga tatacataat taatgttttc 30660 gcggtagtag atataatact ataaacaata gcatgtgcaa atattattca gtaattaaag 30720 caaacagaat agaaaatacg tatagtaatt gacttcaatc caggaattac attaaaatac 30780 atccttgtta attgaatctt acgccttttt aaagtcctcg caaagataaa gcttaccgcg 30840 ttacaatttg ttggtcttac aacagttctt taaacgtgaa agagtaattg acctttataa 30900 atagaattat tttgaatgta ataaattctt attttttgtt ttatcattat aatagtagga 30960 attagaaaac actttcaagt agctaggttt agcatcttta taaataagta tgattgaata 31020 agcagagatt aattattttt aagaaattta aatatatcgt tttcaaatta accatttgag 31080 ccacaatcat ctaactagtt atttgaaata tcataaaaaa atcattgcag aaatcagttt 31140 gaagctgctt aagtcactca taataacaac ataaaacact tatttgaagg tttgcacttt 31200 actatatgag atgtttgttg ctggtaatat cgtaagcaac gatcagcaaa agttctgttg 31260 tagcgtttga ttcaactttc ctgtttgtaa ttacctttga tttaataaga aatttccttt 31320 ttctaaatac tgactgatct tatcatataa atgctttgct ctcaaaaggc ttggctgctt 31380 gaacctgacc actcatccaa tgctataaaa ttcactagtt gtataggtgt caccaaacag 31440 tttattgaga ttaaacattt aaagctttaa aactaatgaa tcagttttat taagcattgg 31500 tagcttttct tttcgttttg aggagagtcc agttgttaat gataattgct gctagtttta 31560 tatcagattt acaatcacga agatatcctt cacttcttca tttcaatcat tttttgtttt 31620 tctttcatct taaggctaag aaaggatgct atcacgattc attaaaagaa catatagcac 31680 tcaaacttct tcacctgtag tcggcatcat cggttctggg ccggctgctt tttacacagc 31740 ccacagactc ttacgaaatg acccaaatgt caaaatagat atgtttgaat cccgcccagt 31800 tccatttggg cttgtacgtt atggagttgc cccagatcat ccagaagtta aggtaagtct 31860 gttaagccaa gaaatattga ttggtttaaa aatggatctt attaaattta ttatacagct 31920 aacctctatt gtagcatgta gaacacaagt tttccgaaat tgctgagtct acacaatttc 31980 gcttccttgg taacgtaaac gttgggactg atgtttcttt acgggatttg actaaaaatt 32040 atgattgttt ggtccttgcc tatggagctg ctggggacaa gagactggga attccagggg 32100 aggacttgtc aggtgtttat agtgcgcgag aagtggtggg ttggtataac agtgatccca 32160 gaaatcaaaa tcttgagttg gatttaagtc aggtagagga tgcagtagtt attggacatg 32220 gtaatgtttc acttgatgta gctcgaatcc ttttaagtaa tcctgctcaa ttatccccaa 32280 ctgacattaa tccattgttc ctcaaatcac ttgaaagaag caatttaaaa agattacaca 32340 ttgtaggaag aagaaacata ttttctgtct cgtttactat caaagaattg agagaactgt 32400 ttgccctatc aagtgcagtt ttctttgctc cttcctttaa ttattctaca aagtggatga 32460 atgaaacaga tgcaagcggt ttggatagac ctagaaagag attgttaaag ctattagttt 32520 ccgaaatcca gaaagctgtt tcagagaaac gagtagcccc ttattcaaaa gacaagaaat 32580 gttggaattt ggaatttggc ttaacacctg ttgagattct aggacataag ggaaatgttg 32640 aaaatgttcg ctttcagatt acagatagca taagaacaga tgctgagtca aaatttacaa 32700 ccatacccgc acagttgttt atccgaagta tagggtataa aagtatgccc ttgcctggaa 32760 tgaaagacgt tggcgttcca ttcgacgatg caaaaggaat tgtaaaaaat gttaacggat 32820 ttgttcgtcc tggcatttac actagtggat gggtgaaaca tgggccaatt ggagtcattg 32880 ctacgaccat gatggatgca tttgctacag cggatacaat aactaaggat tggaaatcca 32940 aaaaggaatt tctcaaaaat agtaagctag gatgggatgg cttaaaaaag aacattaaaa 33000 cacctgtaat tcactggaaa gattggaagg taattcgaaa tgcagaaatt gaaagaggtc 33060 ttaggcatga gtctctcagt gaaaaattca ggtcgaatga agatatgatt aaactaatat 33120 atcccggtaa aaaatagata ctgcatagtt taattaaatc atttgtaact tgaatattgg 33180 tttgtataat gaaataagtc ttatgccaaa aaaatatatc gcaagctggt cttacagatt 33240 tctttgtaaa gcattttaaa atggaccaac tctaaaaatt ccggaataaa tagtaagaag 33300 tgcctgtgaa tcttccaata cctcgttaaa gtccgaatta tataactaac tttttaattt 33360 tttttccaac gattgtatct tggattactt tgaagttc 33398 //