ID SPBC342 standard; DNA; FUN; 14508 BP. XX AC AL096809; XX SV AL096809.1 XX DT 07-JUL-1999 (Rel. 60, Created) DT 07-JUL-1999 (Rel. 60, Last updated, Version 1) XX DE S.pombe chromosome II cosmid c342. XX KW 26s proteosome regulatory subunit; 5S rRNA; DNA damage checkpoint; KW gas1 family; glucosyltransferase; glutaminyl-trna synthetase; KW membrane glycoprotein; mts3; rhp9; tRNA Asn. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-14508 RA McDougall R, Rajandream M.A., Barrell B.G., Saunders D., Quail M., RA Harris D.; RT ; RL Submitted (06-JUL-1999) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; O43053; O43053. DR GOA; P50524; P50524. DR GOA; P87074; P87074. DR GOA; Q9Y7Y8; Q9Y7Y8. DR SPTREMBL; Q9Y7Y5; Q9Y7Y5. DR SPTREMBL; Q9Y7Y6; Q9Y7Y6. DR SPTREMBL; Q9Y7Y7; Q9Y7Y7. DR SWISS-PROT; O43053; ALG6_SCHPO. DR SWISS-PROT; P50524; MTS3_SCHPO. DR SWISS-PROT; P87074; RHP9_SCHPO. DR SWISS-PROT; Q9Y7Y8; SYQ_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c342 is overlapped at the 5' end by cosmid c14F5 and at CC the 3' end by cosmid c16G5. XX FH Key Location/Qualifiers FH FT source 1..14508 FT /chromosome="II" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c342" FT /map="IIR" FT CDS complement(1..675) FT /db_xref="GOA:O43053" FT /db_xref="SWISS-PROT:O43053" FT /label=SPBC342.01c FT /note="SPBC342.01c, len:225, SIMILARITY:Saccharomyces FT cerevisiae, ALG6_YEAST, glucosyltransferase alg6, (544 aa), FT fasta scores: opt: 781, E():0, (51.8% identity in 220 aa)" FT /partial FT /gene="SPBC342.01c" FT /gene="SPBC3F6.06c" FT /product="probable glucosyltransferase" FT /protein_id="CAB46771.1" FT /translation="MLSEFENGAPVQQFVSRFRSYSSKFLFFPCLIMSLVFMQWLISIG FT PYSGYNTPPMYGDFEAQRHWMELTLHTPVSQWYFRDLQWWGLDYPPLTAYVSWFFGIIG FT HYFFNPEWFADVTSRGFESLELKLFMRSTVIASHLLILVPPLMFYSKWWSRRIPNFVDR FT NASLIMVLFQPALLLIDHGHFQYNCVMLGLVMYAIANLLKNQYVAATFFFCLALTFKQM FT ALY" FT misc_feature 1..1309 FT /note="nominal overlap with cosmid SPBC3F6 S. pombe FT chromosome 2" FT misc_feature complement(1112..1327) FT /note="annotated as RNA-binding protein fragment in cosmid FT c3F6 but no homology or splice data to suggest that it's FT real" FT CDS 2390..4825 FT /db_xref="GOA:Q9Y7Y8" FT /db_xref="SWISS-PROT:Q9Y7Y8" FT /label=SPBC342.02 FT /note="SPBC342.02, len:811, SIMILARITY:Saccharomyces FT cerevisiae, SYQ_YEAST, glutaminyl-trna synthetase, (809 FT aa), fasta scores: opt: 2707, E():0, (53.5% identity in 819 FT aa)" FT /gene="SPBC342.02" FT /product="probable glutaminyl-trna synthetase" FT /protein_id="CAB46772.1" FT /translation="MDQDYEELRAKFTKIGLNETTVKDTLKNKKLSSSLNKVIEETNVG FT SSGCDRTIGNLLFTLANASLKQKDPKSNAHEAFIASKIVSGDLKTNLQVNAAITYCKDK FT DTIDESEFDKETGVGVVLTPEQIEQLVGDYVAENKSKILEQRYQLLNPSASALRQHALL FT KWAPQLEVKQTLDRKFLELLGPKTEQDAAAGKKKGAKAKNSKQKTVDSGKAKEQKIVSE FT QSKKYNMFEEGFLAKLHKPGGNTQLIPERMKEHLQATGGGVVTRFPPEPNGYLHIGHSK FT AIAVNFGFARYHNGVCYLRFDDTNPEAEEERYFESIKDLVAWLGFQPYKITYSSDYFDK FT LYELAEELIKRDKAYVCHCTDAEIKKARGGEERGPRYACVHRDRPIEESLLEFRNMRDG FT KYQPKEAILRMKQDLSDGNPQMWDLIAYRVLNSPHPRTGDKWKIYPTYDFTHCLVDSFE FT NISHSLCTTEFILSRVSYEWLCNALEVYCPAQREYGRLNVVGTLMSKRKIMKLVKEGYV FT HGWNDPRLYTLVALRRRGVPPGAILEFVSEVGVTTAVSNIEVARFENCVRKFLENSVPR FT LMFLPDPIKVTLENLDDSYREQIEIPFNPKDPSMGSRSAFLTKHIYIDRSDFREEASSD FT FFRLTLGQPVGLFRASHPVVAKRVVKNDEGEPIEIIAEYDASSSKKPKTFIQWVSRDKE FT SNSPVLIAETRLFNNLFKCDNPAALKEQELAAQLNPESEVVLKNSIIEPGIYDLIKSAP FT WPKTDSSAGVDKAENPESVRFQAMRVGYFCLDEDTKKPNHLVLNRIVSLREDSAKNKN" FT misc_feature 3173..4624 FT /note="Pfam match to entry PF00749 tRNA-synt_1c, tRNA FT synthetases class I (E and Q)," FT CDS 5220..6590 FT /db_xref="SPTREMBL:Q9Y7Y7" FT /label=SPBC342.03 FT /note="SPBC342.03, len:456, SIMILARITY:Schizosaccharomyces FT pombe, YDYD_SCHPO, hypothetical 53.7 kd protein c11e3.13c FT in chromosome i precursor., (510 aa), fasta scores: opt: FT 1537, E():0, (56.0% identity in 430 aa)" FT /gene="SPBC342.03" FT /product="putative gas1 family protein" FT /protein_id="CAB46773.1" FT /translation="MGVANIIYALFLLGPSIFLKATAQTHPIVIKGNAFFDSKTNERFY FT IRGVDYQPGGSSSLVDPLASRSCKKDVEIFKKLGINTVRVYQVDNSADHDKCMNALSEA FT GIYVILDLNTYRHSISRAHPALSYNKVYLQHLFATIDAFKGYDNVLGFFSGNEVVNDED FT TTAITWVKAVTRDVKAYIKKHSDRHIPVGYSAADVAENRLQLAHYFNCGDESERADFYA FT FNMYEWCGYSSMTVSGYYDRIKEFSNYSIPLFLSEFGCNTVEINDDTTPNRPFTEIEAI FT YSHDMTPVFSGGLVYEYSAEPNHYGLVVIDKDDERRVSRNFITLMKQYAKTPNPKGDGG FT YKKAGSPSKCPANSTQFNAWEKLPEMPEGAKIYMEKGAGEPLGIEGPTNMWSPFHDGDD FT DESTSRRPKPKNKPSNVTSTTSYTSGMTSSSESGSSKIGVAFCQALFITVLIATLSF" FT CDS join(7271..7350,7391..7472,7539..8252) FT /db_xref="SPTREMBL:Q9Y7Y6" FT /label=SPBC342.04 FT /note="SPBC342.04, len:291, SIMILARITY:Homo sapiens, FT G100_HUMAN, 110 kd cell membrane glycoprotein., (407 aa), FT fasta scores: opt: 297, E():6e-12, (26.4% identity in 363 FT aa)" FT /gene="SPBC342.04" FT /product="putative membrane glycoprotein" FT /protein_id="CAB46774.1" FT /translation="MSLITFKAGKLRRVPGTKLLRADPEKGYIVMNRDAYGLIHFQWAK FT RNDLENPEDDIIVFSSECTFEKVTECTTGRAYMLKYPSSAHSLFYWMQEASDDNDTSYA FT ERINSYIKDQDLLDPARSDVATVSDMMEVDTVEQSEPIAQPTESSKESSEIGAPNSDEI FT NSSEAVRNLLATISAQAGFGGSTVDLCEILKPSNLTDLLCQEGVIDRLMPYMPPDTPNN FT LEGVLAIVSSPQYAQALRSFSQALNSPGGVNIISALGLSLDESANPNEGGALQFLKAIA FT RFVSRNNGSE" FT misc_feature 7351..7356 FT /note="gtatgc, splice donor sequence" FT misc_feature 7377..7390 FT /note="ctaacaaatcacag, splice branch and acceptor" FT misc_feature 7473..7478 FT /note="gtaagt, splice donor sequence" FT misc_feature 7525..7538 FT /note="ctaaccaagtttag, splice branch and acceptor" FT tRNA complement(9026..9099) FT /note="tRNA Asn anticodon GTT, Cove score 75.79" FT rRNA complement(9333..9473) FT /note="SPRG5SC K00770 Yeast (s.pombe) 5s rrna gene and FT flanks" FT CDS 10060..12396 FT /db_xref="GOA:P87074" FT /db_xref="SWISS-PROT:P87074" FT /label=rhp9 FT /note="SPBC342.05, len:778" FT /gene="rhp9" FT /gene="SPBC342.05" FT /product="DNA damage checkpoint protein rhp9" FT /protein_id="CAB46775.1" FT /translation="MEVNDTSLHKGFGLDINSQRVFGAQAAISRNNYSKVNASINPSPP FT RSNDNSNKEFSYSKDVNNNGAVEELSLTQLFEVPSQAAFAKQSSQDISDDELIQHDSRK FT VISSPYSPKQTHTVLKRLYDRQSVISDHEKLLTPQNVSNSSQILSPFTSLLPSTLSTLK FT DTPLSVSQNEKNLETVGEVLVPETVAQHRTKFYDYTLDEMENETESGQVETTPTRLATS FT LGSPVLYGRVESTPPAFLPETSEKQYKRKFSFTEPSSEKVDNTETKFSKKTKNINDENF FT PNPFNVISSYETSASPSTVIDQSSQVSSIFVNKRLRKSVNNQAISRSDSLSLDTPKIDS FT LFTRASIKPLKPSQSPNSRRSFKNRVLAFFKGYPSFYYPATLVAPVHSAVTSSIMYKVQ FT FDDATMSTVNSNQIKRFFLKKGDVVQSTRLGKIKHTVVKTFRSTNEQLSLIAVDALNND FT MVILAHGEIEVTVPISTIYVAPVNIRRFQGRDLSFSTLKDMKFEETSFLPSHDSQRNRS FT SLKERDSSFVKKNLDSESNQLIFDDCVFAFSGPVHEDAYDRSALETVVQDHGGLVLDTG FT LRPLFNDPFKSKQKKLRHLKPQKRSKSWNQAFVVSDTFSRKVKYLEALAFNIPCVHPQF FT IKQCLKMNRVVDFSPYLLASGYSHRLDCTLSQRIEPFDTTDSLYDRLLARKGPLFGKKI FT LFIIPEAKSWQKKIENTEQGQKALAHVYHALALGADVEIRPNVAHLECDLILTMDGNIV FT DETNCPVVDPEWIVECLISQSDIST" FT misc_feature 11662..12018 FT /note="Pfam match to entry PF00533 BRCT, BRCA1 C Terminus FT (BRCT) domain," FT CDS complement(12613..13722) FT /db_xref="SPTREMBL:Q9Y7Y5" FT /label=SPBC342.06c FT /note="SPBC342.06c, len:369, SIMILARITY:some to, FT Saccharomyces cerevisiae, Q07794, chromosome xii reading FT frame orf yll002w., (436 aa), fasta scores: opt: 212, FT E():1.9e-07, (29.2% identity in 271 aa)" FT /gene="SPBC342.06c" FT /product="hypothetical protein" FT /protein_id="CAB46776.1" FT /translation="MPDLWSESILEGRKLSIYHLKSTLEKCPFLFGQSKKSKDFQFGSH FT LFLVEEQNVFIFGMECIVYEKNKEFIVFVSKADSTGFGSKGVSCNSLAFCCLVTLIDGL FT RKQGAENVTLTLFAIAQGQYLFPESVDNGQKHVLNDSGLLRWWVNCLEKLRKYYTDSEA FT PNDSEKQKNSTLLPKAYLFVPGLENIRSYLPNRHWIESNAITTGKAVEELPRFPDDPKC FT RYLCELQDEKSDMSVEEFWDTLTYRQECSSGKLVGFFTLQLQFYQTREFIAKDNFGDSG FT VMIPAKLYRVTYDTLLKHPFGSLSDAQSSTEKFLSNTLSAVQNLKDFHYKRYKLDICGL FT AKRDDRKNHNHSKPATQANILQPRKKVKK" FT CDS join(13979..14129,14181..14508) FT /db_xref="GOA:P50524" FT /db_xref="SWISS-PROT:P50524" FT /label=mts3 FT /note="SPBC342.07, len:159" FT /partial FT /gene="mts3" FT /gene="SPBC342.07" FT /gene="SPBC16G5.01" FT /product="26s proteasome regulatory subunit mts3" FT /protein_id="CAB46777.1" FT /translation="MSTLDLNHLADLYDRKDWNACKKELLKLKVELAKQNLFVPTSDKE FT KASFARNVFEYGVLVSIQTCDIESFARYASQVIPFYHDSLVPSSRMGLVTGLNLLYLLS FT ENRIAEFHTALESVPDKSLFERDPYVEWVISLEQNVMEGAFDKVASMIRSCNFPE" FT misc_feature 14130..14135 FT /note="gtatgt, splice donor sequence" FT intron 14130..14180 FT /note="confirmed intron" FT misc_feature 14165..14180 FT /note="ctaatcttccttatag, splice branch and acceptor" FT misc_feature 14408..14508 FT /note="nominal overlap with cosmid SPBC16G5 S. pombe FT chromosome 2" XX SQ Sequence 14508 BP; 4700 A; 2528 C; 2623 G; 4657 T; 0 other; atatagagcc atctgtttaa acgtaagagc taaacagaaa aaaaacgtag cagctacata 60 ttggttttta agcaaattag cgattgcata cataactaaa cccagcataa cacagttgta 120 ctgaaaatga ccatgatcaa ttaagagtaa agcaggttga aaaaggacca taattaggct 180 agcatttctg tccacaaaat taggtatacg gcgcgaccac catttggagt aaaacattaa 240 agggggaacg agtattagaa gatgagatgc aataacagta gatctcatga ataattttaa 300 ttcaagactt tcaaatccac gagatgtgac atcagcaaac cattcggggt tgaaaaaata 360 atgcccaatt ataccaaaga accaagaaac atatgctgtt aaaggaggat aatctaatcc 420 ccaccattgc aaatctctaa aataccattg agacacagga gtatgcaatg ttagttccat 480 ccaatgtctt tgcgcttcaa aatcgccata cataggaggt gtattatacc cagaataagg 540 accgatagat ataagccatt gcatgaaaac taaactcatt ataaggcatg gaaaaaataa 600 aaatttagat gaataggatc gaaaacgaga aacgaattgt tgaacgggag ccccattctc 660 aaactcagat agcatgtttt aagcggccgt caaacggtaa ggatttcgct ttaaaacttt 720 gggtttctaa attaaaatat ccaacttgga aagcttaaag attaaaaaac gagtgaattt 780 gtatccggaa tgttttaaac aaggaaaagc taattcaaag cagatacaag ttgggataac 840 agtgaaatgg gttgggaacc acgaagtgga ctatgggtcc accattgcga tcatcgtgaa 900 atatggtttt ataatgtcca aaaaaatcaa ttcacttttt aattcattct ttctttctta 960 ttttttattt tcagtttcaa agcctaaaaa ttaaatacgc gcaaagttat cactacataa 1020 ttgatccaag ggtgagcaat aacataaaaa atgagttgat aaacatgaaa attaagctgt 1080 atcacttatt gactgattta cttttctctt aagataggta aatgttagaa taaattgagc 1140 ttggcaagtt aggagtttgt ttcagtgata ctagcccatt aaattcaatg aactgaaata 1200 tattacttaa ttgtttgctg tttaataatt tagctctaac gaaaatctta ttagcaaaga 1260 acatgctaag aaaaataatt cccttaatac atttactatg taattgatct cgaatttgta 1320 gctgcaatta agagctttga aattttaaaa gtcttttcgt tcatgataat ttctaaagaa 1380 aacccttgtt gggctaaaaa aaaaagcgac ggtttgacga aaaatcatgc ttttaaaacc 1440 agaattcata ataatattgt aaaattattt cttggtctgt tacagtttta agtaaaagca 1500 agcattatcc taatattttc tttttgcgtt gatggaacac tgtgaaatct ccattatttg 1560 tataatttta agcgatattt actaatcata tgtttagttt aattttttgt aaaacgattt 1620 gaaatagaaa ctgaagttgt atagttacta acattatttg cattctcgca ttgtttgtat 1680 attgtttact cttcagaata atttcaatat ttatgcttaa gctaaatgaa atattttcaa 1740 ggactcacaa atagttattt atatatttta tgaaaattta aaacctaatt agattaaatt 1800 taattaaaat acccaaaagt acattcgttt gagaagagat accagattga atgaataaaa 1860 acatactaac tgcttggcgg gcaaatgaaa ttcatttgta cactacagtg gttgatgctg 1920 tttttaaaat ctaaactttt atagcaataa agaatcatcc tcccttgagt attaaagtga 1980 aagcaaaaaa gccttactag gcaagagctt agaaccgata aacaactatt catttaaagg 2040 aaaaaaacaa agattcggaa agcattttgc gttctctatt tttttaaaaa aaattaaaaa 2100 tatctcaaaa gcgcaaaagt gtgaattcct gttttaattt tcaaaccgta aacaaaatgt 2160 tttaaatttt aatttaatac tgaaactact tttattaact taacgatttt taagattagt 2220 tccctactcc gctgttatgc agattaacgc aatgatagga gcttatcaca tgaattgaaa 2280 gataataaca gctttattaa aaacttaacc gtaccctctc atttttcatc gcgtttgctg 2340 ttattgcaat acttatacat tttttggagg gaagttttat tatactaaaa tggaccagga 2400 ttatgaggag ttacgtgcca agtttacaaa aataggatta aatgaaacaa cggtaaaaga 2460 tacgttaaaa aataaaaagc tttcttcttc attaaataag gtcattgagg aaactaacgt 2520 tggttcttcg ggatgtgata gaacaattgg aaatttgcta tttacattgg ccaacgcttc 2580 tttaaaacaa aaagacccga aatccaatgc tcatgaggca ttcatagctt ccaaaattgt 2640 atctggagac ttaaaaacaa acctccaagt caatgcggct attacctatt gcaaggacaa 2700 agacacgatc gacgaatctg agttcgataa agaaactggt gttggtgtag tcttaacacc 2760 tgaacaaatt gaacaactcg tcggtgatta tgtcgctgag aataagtcaa aaattttgga 2820 gcaaagatac cagctgttaa atccttctgc ctctgcttta cgtcagcatg ctttattgaa 2880 atgggctcct caactggagg tcaagcagac ccttgatagg aaattccttg aactcttggg 2940 accaaaaacc gaacaagatg ctgccgctgg taaaaaaaaa ggcgcaaaag ccaagaattc 3000 gaagcagaag actgttgatt ctgggaaagc taaggaacaa aaaattgttt ctgaacagtc 3060 taagaaatat aatatgtttg aggaagggtt tttagcaaag ctacataaac caggtggtaa 3120 tacgcagctg attcctgaaa ggatgaagga gcacctgcag gctactggag gcggcgttgt 3180 aaccaggttt cctccggaac caaatgggta cctccatatt ggccattcca aagcaatcgc 3240 tgttaatttt gggtttgctc gctatcataa cggcgtttgt tatttacgct ttgatgatac 3300 taatccggaa gctgaagaag agcgttactt tgaaagcatc aaggatttgg tagcctggtt 3360 gggattccaa ccttataaga tcacctattc cagtgattac tttgataagt tatatgagtt 3420 agccgaagag ctcattaagc gggacaaggc atatgtttgt cattgtaccg atgctgaaat 3480 taaaaaagct agaggtggtg aggagcgcgg tcctcgttat gcttgtgttc atcgggaccg 3540 cccgatagaa gaatcgcttc ttgaatttcg taatatgcgt gatggaaagt atcaaccgaa 3600 ggaggctatt ttacgtatga aacaagatct cagtgatgga aatcctcaaa tgtgggacct 3660 tattgcctac cgtgttctta attctcctca tcctcgtact ggagacaagt ggaaaattta 3720 cccaacttat gattttaccc attgtttagt tgattcgttc gagaacattt ctcactcttt 3780 gtgtacgact gagtttatat tatctagagt aagttatgag tggttatgta atgccttgga 3840 agtttattgt cctgctcagc gtgagtacgg tcgtttgaac gttgtcggaa ccctcatgag 3900 caaacgaaaa ataatgaaat tggtaaagga aggatacgtt catggttgga atgatcctag 3960 gctatatacc cttgtagctc ttcgccgccg aggtgttcct ccaggtgcta tccttgagtt 4020 tgttagtgaa gtcggtgtca ctactgccgt cagcaatata gaagttgctc gatttgagaa 4080 ctgtgttcga aaatttctcg aaaacagtgt accacgtctt atgtttcttc ctgatcctat 4140 caaggttaca ttagaaaatc tagacgactc ttacagagag caaattgaga taccctttaa 4200 tcctaaagat ccttctatgg gatctcgttc tgcttttctt acaaagcata tatacattga 4260 ccgttctgat tttcgtgagg aagcatcttc tgactttttc cgtttgacat taggtcaacc 4320 ggttggcttg ttccgtgcct ctcatcctgt agttgccaaa agggttgtaa aaaatgatga 4380 aggggaacca atagaaatca tcgctgagta cgacgctagc tcttcaaaga agcctaagac 4440 ctttattcaa tgggtgtcta gggacaaaga aagtaatagt ccagtactta ttgctgaaac 4500 ccgcctcttt aataatcttt tcaaatgtga taaccctgcc gccctaaaag aacaagagct 4560 cgctgcacaa ttgaatccag agagcgaagt cgtactaaaa aattccatta ttgaacctgg 4620 catttatgat ttaattaaat cggcaccttg gcctaagact gattcatcgg ctggtgtcga 4680 caaagccgaa aatcctgaaa gtgtccgttt tcaagctatg cgggttggat atttctgttt 4740 agatgaggat actaagaaac caaatcatct tgtattgaat agaattgtat ccctcagaga 4800 agattcggct aagaataaaa attaggaagc ttagaacact tgtgatattt gaggggaatg 4860 ttttaggatt gaatttgttg attagggaat taatagctgt tagcgtgatt ataatctatg 4920 ttttgagtca tttatggtat tattttcgaa ttgctagcaa atagcgtaca agaaatgttc 4980 actatttttt gataaacaaa acatatcctt ctttttgatt tgtttattga accattattt 5040 gtttacgttt atctcaggtt gctaattata ataccttacg tttgtttgtt tacaaataaa 5100 ctgaaagact ataaatacta gtgctggact tctctatcta ctgccaagat atatatttag 5160 tgcaatcaaa cggtattttt aagcattctt ggagaaggta ttgaatatta tattgcaaca 5220 tgggtgttgc taatattatt tatgcattgt tccttttagg accctctatt tttttaaaag 5280 ctacagcaca aacacatcca atagtgatta aaggaaatgc ctttttcgat tctaagacta 5340 acgagcgttt ctacataaga ggtgttgatt atcaacccgg cggttcctcg tctttggttg 5400 acccattagc atccagatct tgtaagaaag atgttgagat attcaagaag ctcggaatta 5460 atacggttcg agtttaccaa gtcgataatt cagccgacca tgacaagtgt atgaatgcgt 5520 taagtgaagc aggcatttat gtgatcttgg atttgaacac ctataggcat tcaatatctc 5580 gtgctcatcc tgctctatct tacaacaaag tttatctgca acatttattt gctactatag 5640 acgcattcaa aggatacgat aatgtactag gattcttctc cggcaacgaa gtagtaaatg 5700 acgaagacac taccgctatt acatgggtta aagcggttac tagagatgtg aaggcataca 5760 ttaagaaaca tagtgatcgg catattccag ttggttattc tgctgccgat gtagcagaaa 5820 accgtttaca gctagctcat tattttaatt gtggagatga gagcgaacga gcagattttt 5880 atgctttcaa tatgtatgaa tggtgtggat actcaagtat gactgtttca ggttattatg 5940 atcgcatcaa ggaatttagt aactattcaa ttccgctatt cttgtcagaa tttggttgca 6000 atactgttga aataaacgac gatacgactc ctaaccgacc ttttacggag attgaagcaa 6060 tatattcaca cgatatgacc ccagttttct ctggtggtct ggtctacgaa tattcagccg 6120 aacctaatca ttatggatta gtcgttattg acaaagatga cgagcgtaga gtgtcgagaa 6180 attttataac gttgatgaag caatatgcca aaactccaaa tccaaaaggg gatggtggtt 6240 ataaaaaggc cggatcgcca agtaaatgcc ctgctaattc tactcaattt aacgcatggg 6300 aaaaattacc tgaaatgccg gaaggtgcaa aaatttacat ggaaaaaggt gctggcgaac 6360 ctttgggaat tgaaggtcca acgaatatgt ggtctccttt tcacgatggt gacgatgatg 6420 aatctacctc tcgacgtccc aagccaaaaa acaaaccatc taatgttact agtacaacta 6480 gttatacatc tggcatgact agctcctctg aaagcggttc atcgaaaatt ggcgttgctt 6540 tttgccaagc actttttatt actgtcctta tcgctaccct cagcttctaa aaaaagaatt 6600 gttgaaattt agagcttagc tgaatgactt gtttcagtaa ttcaattgaa ctcttctaaa 6660 gccgatttgt tacaagacaa tgctaacatt tccagttaca atttagtata attaaatgaa 6720 atcatattgt ttatcattta cggacgttga aaggattgct aatgtagtat ttgtctgttc 6780 aagtaatttt tggtattcct aaagaaccaa cttcattatg attcagggct taaagggtta 6840 taggaattaa catatttttc ctttaaatat cgtattgact aagaattcac ctaatataaa 6900 tagcgaattc aacgctcaat tgcaatcgta ggatctgaaa tataactact taattgacag 6960 ccaaagataa ttcagaatct aaatatgctg tatttacgct ttctcacaaa cgtagtaagg 7020 tatcatttac ataacattat taaatatttg attattttat tttataagtt atatttattt 7080 ttcctcgaag ctatcatact acccaaatta agctatgttt gtttcaagga taggattttt 7140 gcagtgtaat caaacgttat tgttaaacaa cgcaacgaac tacaacgaaa gctagagctt 7200 cgtggtttcg acacagtaca tacaacctgt cttttgcatt tcgcagttta agcagtttgc 7260 gattgggata atgtcgttga taactttcaa agcaggaaag cttcgcagag ttccaggaac 7320 aaagctttta cgtgctgacc cagaaaaagg gtatgctcgc atattatgta tgatagctaa 7380 caaatcacag ttatatagtc atgaatcggg acgcctatgg attaattcat tttcaatggg 7440 caaaaaggaa tgatcttgaa aatcccgagg atgtaagtat cactttcaat accacctgta 7500 acacattaaa agttctagtc gatactaacc aagtttagga tataattgta ttttcttctg 7560 agtgtacatt tgaaaaagtt acggaatgta ccactgggag agcttacatg ctcaaatatc 7620 cttctagcgc tcatagccta ttttactgga tgcaagaagc ctcagacgat aacgatactt 7680 cttacgctga aagaattaac agctacatta aggatcaaga tttattagat ccggcccgct 7740 ctgatgttgc aacggtttct gatatgatgg aagtggatac tgttgagcaa tcggaaccta 7800 ttgctcaacc aactgaatct tcaaaagaga gctccgagat tggagccccg aacagcgatg 7860 aaattaattc atcggaagct gtgaggaatc tattggctac aatttctgct caggctggat 7920 ttggaggtag tacagtcgat ctttgcgaaa tcctcaaacc ttcgaattta accgatcttt 7980 tatgccaaga aggtgttatt gatcgactca tgccttacat gcctcctgat accccaaata 8040 atttggaggg ggttttggct attgttagta gtcctcaata tgctcaagct ttgagaagct 8100 tttctcaagc tttaaattct cctggtggtg taaacattat ttcagcactt ggtctctcac 8160 tcgacgaatc tgccaatcct aatgagggag gtgctctgca atttcttaaa gcaattgctc 8220 gcttcgtgag caggaataat ggttctgagt aatgtcttcg attaagtaat tcgtcgtata 8280 tcaaaaattt ctatttaaaa tattatccgt tgaatcgttt ctttataatt cactgacgat 8340 tcgtattaaa agtttttaaa ttgagcatta ctggcgttct tttttttttt tttaaataaa 8400 tatggaggaa ttaaaatgct ttcatggtag gatttgtcct cttaccaaaa tgagtaagag 8460 taagttggag tacacaatac aatgttgctc gctcaaaatg ctctttacag aatgtttatt 8520 ggtacagttt cattttttct catatatgaa atatttgttt taggaaatag gcaatcttta 8580 tttttcttgc atacaatgct tatctttcct aaacacttaa gatttataaa tgcaatgtat 8640 gttcatgaat atgaactgcg agcgccaagg atgaattaca ttaggacgac taaaaatgag 8700 aagttgcact cccgaagtat ctctacttca tacttcatta ttatttatgc tttatattga 8760 ttattgttgt tttacaaaat atgttttatt tccaaaacag ttggtaaaat gtaggatatg 8820 taatgtcaaa tacataatac caacatctat tcttaataag ttagaaagtt gaacagtatt 8880 gaaatgattt actaaagcta gaaagtagcc aactgtaaat ggttaaagta ttgacgtgta 8940 gtcacattca atttttgcgc aatatcattg aatttcaaat ctaacgattt tacttttgta 9000 aacagccaaa aaagtggtca taaaacggtc agggagggac tcgaaccctc gacctcacga 9060 ttaacagtcg tgcgcaataa ccaactacgc tacccgacct cggtgtcatc cgttacattt 9120 agtaatatat attgttaaaa aaataaagcg tagtaaatgt aattgctttt ttgagctatg 9180 gcttgttaca ttctttctct tgagcaaatt tagacttgct cattacaatc ataatcgctt 9240 tataacgtct atctgcttgt cttcatttgc atgaaaaaaa atcatataaa caatgtatgc 9300 ggatagtcaa ctcaaacaaa atagtagtaa ttaaatagca ataataaaga aggagcctac 9360 agcaccccgg attcccatgt tgtctccaac catagtacta acgaggccct cagacgctta 9420 actgcagtga tcggacggga actggtgttt tcgcctaggt atggccgtag acagctgtta 9480 agttttaata aagtatataa acgatagtta tcactcatta ggaattcgaa tgtatgttgg 9540 ctccactacg aataagatat gaatgttagc aatataacct gaaactatat ttgacattct 9600 ttttttagaa atatcattaa acaagcaaaa tctattttct atgattgttt caaaaagtca 9660 agatgaaaag ttcaaaactc aaatttaaaa ttacttcttc aacattactg attctaacaa 9720 cataaatctc ctatcgaacg tattaataaa agtggaaaca tgctgtagtt tgtacatcag 9780 gtcaaacaat tattaataaa attagaaaat aagtttttct accttgagcc cttcatttcc 9840 atattaatat atatatatat atgattagcc aaatagctgg tgttgtaact aaacgttctt 9900 aactgctttc atataaagta acggtgcaac gtgttactta tgcagagctt acaacagata 9960 aatcgaaatt tgggttaagc cctggttaaa tttgtagttc tgacaattgt gaggtatttt 10020 agatgttttc aatattttgt ttgaaagttt aacaatatta tggaggtgaa tgatacctct 10080 ttgcataaag gatttggcct tgacataaat tctcaacgtg tatttggagc acaagcagca 10140 atttctcgta acaattattc aaaagtgaat gcttcaatta atccttcccc tcctaggagt 10200 aatgataatt ctaataagga gtttagttat tctaaggatg tgaataacaa tggtgctgtt 10260 gaggagctaa gtcttacgca gttgtttgaa gtacctagtc aagctgcttt tgcaaaacag 10320 agttcccagg acatttcgga tgatgaactt attcaacatg attctcgtaa ggtgatatcg 10380 tcgccttatt cacccaagca gacacataca gtgttaaaac gcttatacga tcgtcaatca 10440 gttatatcgg accatgaaaa gctgttgact cctcagaatg tatctaattc ttcccaaatt 10500 ctttccccat ttacttctct attaccatca actctttcaa ctttaaaaga tacacctttg 10560 tcagtttctc aaaatgagaa aaacttagaa accgttggag aagtccttgt acctgaaacc 10620 gtagctcaac ataggacaaa gttttacgat tacactttgg atgagatgga aaatgagaca 10680 gaaagcggtc aagtagagac tacacctact cgactggcga cttctctagg gtctcccgtt 10740 ctttatggtc gagtagagtc cactcctcct gcttttttac cagagacatc cgaaaaacaa 10800 tataaacgaa aatttagctt tactgagccc tcgtctgaaa aagttgataa tacggaaacc 10860 aagttttcaa aaaaaactaa aaacattaat gatgaaaact ttcctaatcc atttaatgtg 10920 atttcttcat atgaaacaag tgcttcaccg tcgactgtaa tagatcagtc tagtcaagtg 10980 agctcaattt ttgtaaacaa acggctgaga aaatcggtta ataatcaagc tatctcaagg 11040 tctgacagcc taagcctgga tactcctaaa attgatagtt tattcactag ggcttctatt 11100 aagccattaa aaccttccca atcaccgaat tcaagaaggt cttttaaaaa ccgtgtactc 11160 gcttttttta aaggatatcc ctctttttac tacccagcaa ctcttgtcgc acccgtacat 11220 tcagccgtaa caagttccat catgtataag gttcaatttg atgatgcaac tatgagcacg 11280 gttaattcaa atcaaattaa gagatttttt ttgaaaaaag gagacgttgt acaatccaca 11340 agattaggaa aaatcaagca tactgttgtg aaaacatttc gatctactaa tgagcaatta 11400 tcccttatag cagtggacgc tctaaacaac gacatggtta ttttggcaca cggagaaatt 11460 gaggttacgg ttcccatttc tactatttat gttgctcctg tgaacattcg gcggtttcaa 11520 ggaagagacc tcagtttttc tactttaaaa gatatgaagt ttgaggaaac atcatttctt 11580 ccttcacatg attctcagag aaaccgctct tctttgaaag aaagggattc ttcctttgtc 11640 aagaagaact tggattcaga aagtaatcag ctcatctttg acgattgcgt gtttgcattc 11700 agcggtcccg tgcatgagga tgcctatgac cgaagtgcat tggaaactgt agttcaggat 11760 catggaggat tagttcttga tacaggctta cgccctttgt ttaatgaccc gtttaaaagc 11820 aaacaaaaaa agttacgcca tttgaaacct caaaagcgaa gtaaatcgtg gaatcaagct 11880 ttcgttgtat ctgacacatt ttctagaaag gttaaatatt tagaagctct agcttttaat 11940 atcccgtgtg tccatcctca atttattaaa cagtgcttaa aaatgaacag agttgttgat 12000 ttttctcctt atttattggc atctggctat tcacaccgtc tagattgtac actttcccaa 12060 cggatagaac cttttgatac cactgattct ttatatgaca gacttttggc aaggaagggt 12120 cctttatttg gaaaaaagat tttatttatt atacctgaag caaaatcttg gcagaaaaag 12180 attgaaaata cagagcaggg tcaaaaagct ttggctcatg tctatcacgc gttggcattg 12240 ggtgctgacg ttgaaattag accaaatgtt gcacatttgg agtgtgattt gatacttacg 12300 atggatggaa acattgtaga tgaaactaat tgtccggtcg ttgatcctga atggatagtc 12360 gaatgtctta ttagtcagtc tgatatttct acttagtttt ggttttttga tatagttatt 12420 tttactaact ccccctgagt ttcactctca ttaatttagc tttttattaa ttttagatat 12480 ttgttgttta ttaatttatt tgcaatactg acgaaaagtg tcaatttcaa tattaaacaa 12540 aaactttctc taaaaatcta catgagagga ttgattggga ttattaaaaa ttttcaacga 12600 acttaaagtc ctttattttt tcactttttt tcgtggctgt agaatattgg cttgcgtagc 12660 aggtttcgaa tggttgtgat ttttacgatc atcacgtttt gccaacccac atatatctag 12720 cttgtagcgc ttataatgaa aatcctttaa attttgtaca gcggaaagtg tgttactaag 12780 aaacttttct gttgacgact gtgcatcaga taaagagcca aatggatgct tcaataaagt 12840 atcgtaagtg actctgtata atttagctgg aatcattaca ccagaatcac caaaattatc 12900 tttagcaata aattctcttg tttgatagaa ctgtagctgt aatgtgaaaa agccaactag 12960 tttacctgag gagcactctt gtctataagt cagcgtatcc caaaactctt caacggacat 13020 gtcacttttc tcatcttgaa gctcgcataa atacctacat tttgggtcat ctggaaatct 13080 tggtaattct tcaactgctt ttccagttgt tatagcgttg ctttcaatcc aatgacgatt 13140 gggtaagtac gaacgaatat tttcaagtcc aggaacaaat aaataagcct taggaagtaa 13200 tgtggaattc ttttgctttt cggaatcgtt tggtgcttca ctgtcagtat aatacttcct 13260 gagtttttcc aaacaattta cccaccagcg taacaaacca gaatcattca gcacatgctt 13320 ttgtccattg tccaccgact caggaaataa atattgacct tgagcaatcg caaacagagt 13380 caaagttaca ttttcggctc cttgttttct aagaccgtca ataagtgtca ctaagcagca 13440 aaaagcaaga gagttacaag ataccccttt gctgccgaat ccggtagaat ctgctttaga 13500 tacaaatact ataaactctt tgtttttttc gtaaactatg cattccatgc caaaaataaa 13560 tacattttgt tcctctacca aaaaaagatg actcccaaat tgaaaatcct tagacttctt 13620 actttgacca aatagaaatg gacatttctc taaagtactt ttaagatgat aaatactcaa 13680 ttttctgcct tctaatatac tttctgacca aagatccggc atattcttta gtttaaagga 13740 taaagagagt taacgcaact acagcaatta ttgtgagtga atactatgtt acaattgctt 13800 aagtgatata atgaatctaa taaaacaacg tcaaaatccg taaggagctt taatttttgc 13860 tggtaaacct ttatagtgtg ttcgttattg atgactattc tgagatgcat ggcaagaggt 13920 gttgtttcta cagctctctt aaaagttcca acttattaca ctctcaatac acatcaatat 13980 gagtacatta gacttgaacc atttagcaga tctttatgac agaaaggatt ggaatgcttg 14040 taaaaaggaa cttctgaaac tgaaagtcga acttgctaag cagaacctct tcgtccctac 14100 tagcgataaa gagaaagcta gttttgccag tatgttattt gtatagttat ctaagaacag 14160 acctctaatc ttccttatag gaaatgtatt tgaatacggt gtacttgtct cgattcaaac 14220 ttgtgatatt gaatcgtttg caaggtatgc tagccaagta attccttttt atcatgattc 14280 ccttgtccct tcatcaagga tgggacttgt tacaggatta aatttgttgt atctattatc 14340 tgaaaatcgt atcgctgaat ttcacacagc cttggaatcc gttcctgaca aatcgttatt 14400 tgaaagagat ccgtacgtag aatgggttat ttctctagaa caaaatgtaa tggaaggtgc 14460 atttgataag gtagcatcca tgattcgatc ctgtaacttt cctgagtt 14508 //