ID SPBC28E12 standard; DNA; FUN; 13000 BP. XX AC AL031517; XX SV AL031517.1 XX DT 08-SEP-1998 (Rel. 56, Created) DT 19-JAN-2000 (Rel. 62, Last updated, Version 4) XX DE S.pombe chromosome II cosmid c28E12. XX KW conserved hypothetical protein; KW GTPase-activator protein for Rho-like GTPases; RhoGAP; transport protein. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-13000 RA Wood V., Rajandream M.A., Barrell B.G., Skelton J., Churcher C.M.; RT ; RL Submitted (07-SEP-1998) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; O74359; O74359. DR GOA; O74362; O74362. DR GOA; O74390; O74390. DR SPTREMBL; O74358; O74358. DR SPTREMBL; O74359; O74359. DR SPTREMBL; O74360; O74360. DR SPTREMBL; O74361; O74361. DR SPTREMBL; O74362; O74362. DR SPTREMBL; O74390; O74390. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c28E12 overlaps cosmid SPBC3H7. XX FH Key Location/Qualifiers FH FT source 1..13000 FT /chromosome="II" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c28E12" FT /map="IIR" FT misc_feature join(complement(222..447),complement(1..92)) FT /note="see c9B6 SPAC9B6.11c for full length CDS" FT misc_feature complement(1..4001) FT /note="nominal overlap with cosmid SPBC9B6, EM:AL049769 S. FT pombe chromosome 2" FT CDS complement(531..938) FT /db_xref="SPTREMBL:O74358" FT /label=SPBC28E12.01c FT /note="SPBC28E12.01c, len:135" FT /gene="SPBC28E12.01c" FT /gene="SPAC9B6.12c" FT /product="very hypothetical protein" FT /protein_id="CAA20648.1" FT /translation="MDSNYNYVHMNKPGVVLFASDWLKDRLPVDDVEVRVEHLPPVTED FT EMTIQHSSANLILMKNKQLRHEPAWKDLELEDLVNAFAFIQGSSNAEGKNTIEDNFETD FT PFKSVKEAPMAPFLEANRRHQGEHASMRYFR" FT CDS 1970..3961 FT /db_xref="GOA:O74359" FT /db_xref="SPTREMBL:O74359" FT /label=SPBC28E12.02 FT /note="SPBC28E12.02, len:663, SIMILARITY: to a region of Sa FT ccharomyces cerevisiae, YLL032c, Q07834, hypothetical prote FT in, (825 aa), fasta scores: opt: 205, E():1.8e-07, (31.3% i FT dentity in 131 aa)" FT /gene="SPBC28E12.02" FT /product="hypothetical protein" FT /gene="SPAC9B6.13" FT /protein_id="CAA20649.1" FT /translation="MDSHVLAFPIPDPSTPPPEEASLYASKCDYYESDIYSQIRRLTEE FT KCIETEKELPVNIKLHVKHKGMSISSSRNELVVTVSGNYKNVYTAKIKILQAIPKILIS FT KLVLEEPLENLLFDEDGYVYEDTMKHLDKITEITGAKIYIMHRSMCHDIDFQLRTDSGF FT SNRLNEQQSFYQRHLESTRHEFSCQKNAENSFFIVFYGDYCSVEHARIRVLALMDEIRG FT LSVVAIATSVSFQPILVGKAFSSTAGMKATESINIYTLPFCSDSIPRLQTLPALNSSKI FT IITGEEEKLQRLEEAFYYAEEHLKLFTHVTEISFVKLFEFLAYEMDELRLIMEENSSFI FT RFPEYFKEGGETSPENSKVKIYSSSIANSEKTALRLAKLASKYVQGKTQFGVEDNEDFL FT RVAGSWRRASTIEKGVSSSELSSIVSSTGSIVETNGIGEKMSFSPLKKLSIPPTEFVAQ FT IAIICMASGVEMLLKTNGIEYFGQENTVPIAMDKASKIFYKFGQSQWHQILLEAPTKDQ FT DFISGKKNGKLDKVKQQCRFNLKNGDILFCPQSTSIFTVDIYSDELERVIKGMNTMLLE FT FPAEMHFYVPEEIHKKLIGFRGEQIQRVTKLYNSYIEFSTTPFDCYGHNVLIRTPSKFS FT ENLWAVRSLFIKTAEGLGYDIPKYLFAN" FT CDS join(5266..5352,5490..5545,5688..6037,6101..8409) FT /db_xref="SPTREMBL:O74360" FT /label=SPBC28E12.03 FT /note="SPBC28E12.03, len:892, SIMILARITY:Schizosaccharomyce FT s pombe, O14014, hypothetical 108.6 kd protein c29a4.11 in FT chromosome I, (969 aa), fasta scores: opt: 404, E():8.2e-18 FT , (23.2% identity in 966 aa), also similar to RGA1_YEAST, R FT HO-TYPE GTPASE ACTIVATING PROTEIN RGA1/DBM, (1007 aa),fasta FT scores, opt:230, E():4.5e-17, (21.9% identity in 990 aa ov FT erlap)" FT /gene="SPBC28E12.03" FT /product="GTPase-activator protein for Rho-like GTPases" FT /protein_id="CAA20650.2" FT /translation="MNSGTTLHLDRLSLETPSERTCFCIKCWESVPSTSQVWFGGKCWH FT SDCFKCVNCNKKLDPSSEDFSQDDQKQIFCKLCVDICNGCSTPICEFNAVSNSQANHPC FT CSNCRAFINSNAFGKFKGQHYCLPCLRKQDEENQKAVMESASGFIPLRNIAQTAENTSL FT TGQNQGFQNPHFIASDSPSSVLSGRMQNTSSPTNSLRPQLKVQTNGYETPGDINSAKSY FT KDIQKDFLLKPKNSFVKTSPSPLANGPSFRSANASPFDSCDSFHSGSSIPIEPVSSRQS FT SVVNNNSVQQPVAYHAFVQSPTENGTLPQLPKNESVVNPPPLRRSSTMNYKSVSTTTSP FT SKYGYVSGRIALSPIHLRGALRDVTNKCNLKVPRNRNSLSNLDEYYVNGLESDETPTKA FT RFPRYPTVFNKLDDKRLSSEPNGLKKRLTNSSNYEASPRAKSLNLSQVSLHQACEPEYN FT RSSLVRASDVFTSNVFDATEESANELAIRISELQAEVGTLLLEATSLASIIEQQTPVSP FT EAFKQELVADLNYRLDYLRKSFQPELSTLLLRRDALSTTVSKLQNAYSTVMEETAYLNV FT KNTELVSLNNQLERELAYLREQQHKKRTSSSFGIFNNDKKSNRTISTPSPRESFSRLQM FT VASSLGFRPKDNKDKESGGYNKRNSKIDLKKSFSKRFHWKRDSPHMSSTPSISEEHLAS FT EEQEDFVPAVGHCKLCGKYSNELRAHYQDCVSSTIDRQYQSKKSESPVWALNPDDFDQN FT RLTLLRVPTLIVSCINFIESYGMDFEGLYRKSGATSQMKKIVALLRNEDTVLDPSEDIS FT AVTSVFKQYLRNLPNPIITYDQYFPFITAANCASFQDKLDGFIMVIKSLPPAHAEILQL FT IIRHLARVAAYSHANRMTSKNLAVVFSPTLIRDPDNSRDVIDMTVKNYSLAFLIDHVHE FT VFA" FT misc_feature 5640..5645 FT /note="gtttgt, splice donor sequence" FT misc_feature 5667..5687 FT /note="ctaattaagacggtttgctag, splice branch and acceptor" FT misc_feature 6038..6043 FT /note="gtaagt, splice donor sequence" FT misc_feature 6085..6100 FT /note="ctaactttaattttag, splice branch and acceptor" FT mRNA 7827..7977 FT /note="mRNA from AU014507 1 151" FT misc_feature 7888..8325 FT /note="Match to PF00620 RhoGAP, RhoGAP domain Score 168.05" FT CDS 9104..10174 FT /db_xref="SPTREMBL:O74361" FT /label=SPBC28E12.04 FT /note="SPBC28E12.04, len:356" FT /gene="SPBC28E12.04" FT /product="hypothetical protein" FT /protein_id="CAA20651.1" FT /translation="MADVIKRCILGPTEAGWFVAKSQIKKPVDQRPVILTHCKLHSKML FT EPKAIVYKKNSSAIPKRVDNILLRSQKPKHIECLLVDSKITKTRSLLKRFGSCLDETST FT IVLLNQSVSLWEDCYSLFPKTETRPRIYLGRFQTLFKSFPFNLISDSFSYRLNLSKLPR FT TPLEKCTVARACKQFPLNQRSPLLDLMGSFERDYVNFSNFSQMLSAQLCDSMAFLIQIF FT PTPLLRQKAANAWIEVLSKLPYFHILDKSFFSPHLLLQSSENQACKFFNIGPQVYFDPR FT ERLLHVKELLKFALKHIDSNDSLFTFLKQTCYTCDSPYAKVFQPDKQSFHSIISRKRLA FT HLEKEYFDKDVSKLVL" FT CDS 10805..11809 FT /db_xref="GOA:O74362" FT /db_xref="SPTREMBL:O74362" FT /label=SPBC28E12.05 FT /note="SPBC28E12.05, len:334" FT /gene="SPBC28E12.05" FT /gene="SPBC3H7.17c" FT /product="conserved hypothetical coiled-coil protein" FT /protein_id="CAA20652.1" FT /translation="MSTAEQLFGAEEEEKYVDQDLSEDEEDERFLKAIRSSRSTKPVVD FT VLKVKSESSADELEERDAHLDRFRRDSTFESETSDHEDFSGGSENELDEETTKNANSIK FT KISLEEVEKQRKAIKRSGVIYLSRIPPYMAPNKLRQILSQYGKIGRVYLTPESSAKRAQ FT RLRNGGNKRVMYEEGWIEFESKRVAKSVAELLNTNQIGGKKSSWYHDDIWNMKYLPKFK FT WHHLTEQIAAENAARESRLKVEIEQGRKQLKQYMRNVENAKMIEGIRKKRSERDTLNVS FT TEFPEETKDLSEDTKPSKQARRFFGQKSIVSNRNMPTDNAKQQKVENVLRRVF" FT misc_feature complement(10917..13000) FT /note="nominal overlap with cosmid SPBC3H7, EM:AL031261 S. FT pombe chromosome 2 " FT CDS complement(12077..13000) FT /codon_start=1 FT /db_xref="GOA:O74390" FT /db_xref="SPTREMBL:O74390" FT /label=SPBC28E12.06c FT /note="SPBC28E12.06c, len:307" FT /partial FT /gene="SPBC28E12.06c" FT /gene="SPBC3H7.16" FT /product="putative trafficking regulator with WD repeats" FT /protein_id="CAA20653.1" FT /translation="VACDERTFLTASLDLTLRLWTLSTNKPIKASLKRVLYGHRYRITC FT VTVCKAFSIIVSGDAGGNLIIWDLNRAEFVSSLSVYKLPIQTIAVNARNAEIAFSTGFY FT CCVVNVNGKILVKDKLSRIYNENSDENILCSCFYTGANSEWLHKNLFITGHPDGIIRIW FT EKRLQSNAKLEAEKNNADRPKWRFHLLRQLQHTKGLGRNRVATRQNIITITPNGQARGI FT FAGDDKGQVFSWMLPDTTSNVHLEKDNTSELCSLCDSRFSLMEWRSQCRACGNSNVCSD FT CVSMLKDTNIKTCYECYRQMPLCYKN" FT misc_feature complement(12797..12910) FT /note="Match to PF00400 WD40, WD domain, G-beta repeat FT Score 24.09" XX SQ Sequence 13000 BP; 4189 A; 2411 C; 2261 G; 4139 T; 0 other; gatggagagc atttcacgct ttataaagtc cgtattgaat tcgggtggag cattgcttgg 60 tggagcaata ggttttcgag cagccttctt agctaataat cagttaataa aattgagcaa 120 caaaaaatta aacaaaggag tagagattcg gtcttaaaaa aagtttcaca acaaccttct 180 tattgttgct cgactagatg aacgaaaatt ttttttcata cccattttct caagtttttt 240 ttggcgttgt ttctctatgt attcaggcgt tacgaacgaa ggagggcctt tagctgagcc 300 ttttttctta acgggtatcg aatctgccat cttgttcttt ttctgatcaa agaatgatat 360 agcaagtttg gataatctat aatcagtgtg gaatcgatcg ataaaaaact tcaaagtcaa 420 tgtacacgtt ttaggacaag tgtacataca atgacttttg agtagacttt atttaagttt 480 tcacagccga aatggattaa cgactgttgg ttcgtacaac ctcaggtata tcatctaaaa 540 taccgcatac tagcgtgctc tccttgatgc cttctgttcg cttcaagaaa aggagccatt 600 ggagcttctt tgactgattt gaaaggatct gtttcaaaat tatcttcaat tgtattttta 660 ccctcggcat ttgaagagcc ttgaatgaat gcaaaggcat taactaaatc ttcgagttcc 720 aaatctttcc aagccggttc atgcctaagc tgtttgtttt tcattaagat tagatttgca 780 ctagaatgtt gaatagtcat ctcatcttct gtaacaggtg gtaagtgttc tactcgcact 840 tcgacatcgt caactggaag tctatctttt agccaatccg aggcaaacaa aactactccc 900 ggtttattca tatgaacata attgtaattc gaatccatta attgttttac tgattccaag 960 taggagactt atggtgcttt tatacggttg gtgttattgg agaagtcggt ggtaagtgtg 1020 taaacaaagc atttagcagc aaagtctact agttgggggg agggagatct ttccatgaaa 1080 atcaattata agaattctag attaatttct tattcacata attctatgaa cttttaagta 1140 gaaataaaaa tcagttaggt ggtttgctac tattcttctc aaaaccttcg tctcttaatc 1200 tatttattcc tattggcatg ttatttttct tgataaataa ggtaaatata tgtgcttgct 1260 tagcttacaa atttcaaaga atgacactaa tagtgcaatg ttttacttaa gctatgattg 1320 tgtccaaaac cctagcaata ctgacagagt tataatgaaa aattaagcgt atatttcaca 1380 atcatataat catattcccc cttttctgaa aaaatgtcaa tggcaaatca tatactgttt 1440 tgagttaaag aggctttggc agatcataaa tcagccatcc taattagtaa aaagaataca 1500 aaattgtgat ggttatgtta aaagtattcc tagtcattag tgcatcacct tagagtcatg 1560 tgctgtatat atatatgtgt ctacctttgc ataaacaaac ttgtattcca cagtcaaact 1620 agtacaatac acatcgttct gcgaaaacgt tctgtttatt tttcagcaaa aaattaaagt 1680 ttaagctatc attcattgcc aatcgcatat caattccaag atttattcat tgtttattta 1740 catttggaag ctaaacaata actttcacgg aagcaacaac acaaccaaca accaaccctt 1800 cagaagtaac tttcggaata attttgtatt caaacctata tcgtttatca ttcctttgga 1860 tttcttttaa tctttctttc gaacacgaaa aacttactct tcactaagct tcgaaatttc 1920 caatcaaacg atttaacaat aagaaaattt tgtgcttaaa atcaccaaaa tggattctca 1980 tgttttagca tttccaattc ctgatccatc tacacctcct cccgaagagg catcccttta 2040 tgctagtaaa tgtgactatt atgaaagcga tatttactct caaattagga gattaaccga 2100 agaaaagtgc attgagacag aaaaagagtt gccagttaat ataaaactac atgtcaaaca 2160 taaaggaatg agcatatcat cttcccgcaa tgaactagtg gttactgttt caggaaatta 2220 taaaaatgtg tacactgcaa aaataaagat tttgcaagcc attcccaaaa ttctaatcag 2280 caaacttgtg ctcgaagaac ccctcgaaaa cctccttttt gatgaagatg ggtacgttta 2340 tgaagacact atgaaacatt tggacaaaat aacggaaata acgggagcaa aaatttatat 2400 catgcatcgt tccatgtgtc atgatatcga ttttcagcta cgtactgaca gcggattcag 2460 caatcgatta aatgaacaac aaagcttcta ccaaaggcat ttagagtcta ctaggcatga 2520 attttcatgt caaaagaacg cagagaattc tttttttatt gtcttttatg gtgactattg 2580 cagcgttgaa catgctagaa ttcgcgtatt agcattaatg gatgaaatca gaggattatc 2640 ggtagtagct attgcaactt ctgtatcttt tcagccaatt ctcgttggaa aagcattttc 2700 tagtactgcc ggaatgaagg ctactgaatc aattaatatt tatacattac cgttttgcag 2760 cgactcaatc cctcggcttc aaaccttacc cgccttaaac tcaagtaaaa taattattac 2820 aggagaagag gaaaaattgc aaagactcga agaggcgttt tattacgcag aagaacatct 2880 aaaactgttt actcacgtaa cagaaatttc atttgttaag cttttcgaat ttctcgctta 2940 cgaaatggat gagcttcggc ttattatgga agaaaattct tcgtttattc gctttcctga 3000 gtatttcaaa gaaggaggag aaacgagccc agaaaattca aaagtcaaaa tctactcatc 3060 ttctatagcg aattctgaaa aaacagcact ccgattggca aagcttgcaa gtaaatatgt 3120 acaaggaaaa actcagtttg gagttgaaga caacgaagac tttctgagag ttgctggttc 3180 ttggagaaga gcgtctacaa ttgaaaaagg agtttcaagc tctgaattgt cctctattgt 3240 atcctcgact ggctccatag tggaaacaaa tggaatagga gaaaaaatgt cattctctcc 3300 tcttaagaag ctaagtattc caccaacaga atttgtagct caaattgcaa taatttgcat 3360 ggcttctgga gtcgaaatgc tcctaaaaac caatgggatt gaatatttcg gacaagaaaa 3420 caccgtgcct atagcaatgg ataaagcaag caaaatattt tataaatttg gacaatccca 3480 atggcaccag atactgcttg aagccccaac caaggatcaa gatttcatat ccggtaaaaa 3540 aaatggaaaa ctggataagg taaagcagca atgccgtttc aacttaaaga atggggacat 3600 cttgttttgt ccccagtcga cgagtatatt cacggttgat atatatagtg acgaattgga 3660 aagagtaatt aaaggaatga acacaatgtt gcttgaattt ccagctgaga tgcactttta 3720 cgttccagag gagattcaca aaaaactcat tggatttcga ggagagcaaa tccaacgtgt 3780 aactaaactt tataatagtt acattgaatt ctcaactact ccttttgact gttacgggca 3840 caacgtgctc attcgcacac catcaaagtt ctccgaaaat ttgtgggccg tccgatcttt 3900 attcattaag acagctgaag gattaggata cgacatcccg aagtatttgt ttgctaattg 3960 aattttaagt cagaatccag tcatcgacct gcccatagat caccacactt tctcgttata 4020 ttttttatgt ccataacaga cactcaagct ggttattaaa ttcggaaact aaattttttg 4080 aaaatcaaaa gtgctccact gtatcaactt tgatacacat cttaagtgca caatataatt 4140 taatgaacgt gatccacgca gaattttgaa gcacatgaca agtttaaact ttaagcagtt 4200 caacgatttg tgcaggacgg caaccactgt tcgtatgcct tttttatttc ttattttgtt 4260 aataaattgt cattgaaaac aaaagataaa acgtcgataa acacagctag attgatataa 4320 taacaacaaa catcttttca gtaaaaagaa gtagaaactg gcactaaccg ttattaatca 4380 acttgctata cgctgtgaca tctaacactc tttgaccagt taattagaat cgtatttgat 4440 gagaaaacga tattgagtta atccatccac tttctttgga atgcatgatg attaaattag 4500 taaattaaag aaacaaaaag ggattacaca agagttgtta aacataaaga cgtcgttcga 4560 ctataaaaaa agacgtgtga accgtaatgc accctttgcg gttattgggt ttcttcggtt 4620 ttttttatac aaattatatt acgcttaact gaacgaacta atcaagtagc acagaaacaa 4680 gccactctta ttttttctca agagtcgagc aatacttcgt tctcgctgac aggattgcta 4740 ataacactaa cgaaagatga acagggggaa tgttgtatag ttcattttta gtcgtacaat 4800 aaatctcgat aaatttgtat aagcaatatc attttaaatg tttcaaaatc tcaaaataat 4860 atgaaggaag caaccatcac ttacacaaag tatgaaacat aaggaaacga tatagaaaga 4920 atctggaaaa taagcaaata ttaataatag ctagatcgaa acctggtggt ttattcgctg 4980 caaagccata gcggtaacaa aaggaacaaa tgccagtgta gccttctata taaacaaagg 5040 tcctattctt tgacctccac cacaaacggc tacgagttta aaagagctag caaatgttgt 5100 aaagccttgg tatttttatt tattttttaa tcaagaacaa actttgaata aaaccgtaaa 5160 gagttttcta tcttagctgc cgctcatttt ttgagctggt gtaatttacc tatccattct 5220 cttgggaaac acctttcttt taattttcag aatattgatt tccttatgaa ttcgggtacg 5280 acacttcatc tggacagact tagtttggag acgccatccg aacgtacttg tttttgtatt 5340 aaatgttggg aagtatgtga ggttcaaaat ttaatcgccg tgtccggaga gcggtctttt 5400 cacaaaacga gaccctgtct tgaaattgga cactgctctt ttattttttc ccagctgtaa 5460 tgaacggcat ttactaactt ttgctctaga gtgttcccag tacctctcaa gtttggttcg 5520 gtgggaaatg ttggcattcc gattggtatg attgaaaatg caaacgttgg gatttttgga 5580 tctttttttt ttcttataga ttgaataaaa aaatataaaa tgctccaaag attacccttg 5640 tttgtgcttc ttgttgtttt gatttactaa ttaagacggt ttgctagttt taaatgtgtg 5700 aactgcaaca aaaaattaga cccttcctct gaagattttt ctcaagacga tcaaaagcaa 5760 atattctgta aattatgtgt tgatatctgc aacggttgct caactcctat ttgcgagttc 5820 aacgcagtaa gcaatagtca agctaatcat ccttgttgct ccaattgtcg agctttcatt 5880 aattcaaatg cttttggcaa gttcaaaggt caacattact gccttccttg tttgcgtaaa 5940 caagatgaag agaatcaaaa ggctgttatg gaaagcgcat cagggtttat tcctcttagg 6000 aatatcgcac aaactgcgga aaacacttct ttaactggta agtttgttgc ttatgtagta 6060 tttattgata ttgtctttat gtttctaact ttaattttag ggcaaaacca aggctttcaa 6120 aacccgcatt ttatagcgtc tgattctcca tcctccgtat tatctggtcg aatgcaaaat 6180 accagctctc ctacaaactc tctccgtcct caattaaaag ttcaaactaa tggttatgaa 6240 acacctggtg atataaactc cgcaaaatct tacaaagaca tccaaaagga cttcttactt 6300 aaacccaaaa attctttcgt taaaacctct ccctctccac tagctaatgg tccctcattt 6360 cgttcagcta atgcctctcc atttgattcg tgtgactctt ttcattctgg aagttcgata 6420 ccaattgaac cagtttcttc aaggcaaagc tcagtagtaa ataataatag cgtgcagcaa 6480 cctgttgctt atcacgcctt tgttcaatca ccaaccgaaa atggtacgct tcctcaactt 6540 cctaaaaatg aaagcgttgt taatcctcct ccacttcgcc gctcttctac tatgaattac 6600 aaatctgttt cgacaacaac atcaccatct aaatatggat atgtgtctgg cagaatagct 6660 ctatctccta tccatttaag gggtgctctt cgtgatgtca caaataaatg taatttaaag 6720 gttcctagaa atcgaaacag tttatctaat cttgacgaat attacgttaa cggattggaa 6780 agcgacgaaa ctcctacaaa ggctagattt cctagatatc ctacggtatt taataagtta 6840 gatgacaaac gacttagtag cgaaccaaac ggcttgaaga aaagattgac gaactcttca 6900 aattatgagg cttccccgcg ggccaaaagt ttaaatttgt cgcaagttag tttgcatcaa 6960 gcatgtgaac ctgaatacaa tcgaagttct ttggttagag caagtgatgt gtttacttca 7020 aacgtatttg atgctacaga ggaaagcgca aatgaactcg ccattcgtat ttcagagctt 7080 caagctgagg ttggaacctt attgttggaa gcgacttcgt tggcttctat catagagcag 7140 cagactcccg tgtcccccga agctttcaag caagagttgg ttgcagattt aaattataga 7200 ttagattatt tacggaaatc ttttcaacct gaactgtcta ccttactttt gaggcgagac 7260 gctttgtcta cgactgtctc taaattgcaa aacgcttaca gcactgtaat ggaagaaacc 7320 gcatatctga atgttaagaa cacagaactg gtaagcctta acaatcaatt ggagagagaa 7380 ttggcatact tgagggagca gcagcataag aagcgaactt cttcctcttt cggaatattt 7440 aataatgata aaaaatccaa ccgaacgatt tcaaccccgt ctccgcgaga atcgttttcg 7500 cgtctacaaa tggttgcatc tagccttgga tttagaccca aagacaataa agacaaggag 7560 agtggagggt ataacaaacg gaactctaaa atagatctta agaagtcatt ttctaaacgg 7620 tttcattgga aaagagattc tcctcacatg tcgagtactc ccagtatttc tgaagaacat 7680 ttagcttctg aagaacaaga ggatttcgtt ccagcggtcg gtcactgcaa actttgcggt 7740 aaatactcca atgagcttag agcacattat caggattgcg ttagttctac tatagatcgt 7800 cagtatcaat ctaaaaaaag cgaatctcct gtttgggctt tgaatcctga cgacttcgat 7860 caaaacaggc taacactctt gagagtcccg acgcttatcg tttcttgtat aaattttatc 7920 gagtcatacg gcatggattt tgaaggtctg tatcgcaaat caggggcaac ttctcaaatg 7980 aaaaaaattg ttgcgttact aagaaatgaa gatacggtac ttgatccaag tgaggatatt 8040 tctgctgtca cttctgtatt caagcaatat cttcgcaacc ttcctaatcc aattattacc 8100 tatgaccaat actttccgtt catcacagca gcaaattgtg cctctttcca agataaatta 8160 gacggtttta taatggtcat caaaagtctt cctccagctc atgctgaaat tttgcagctc 8220 attattagac atttagcaag ggttgctgca tatagtcatg caaatcgaat gacatccaag 8280 aaccttgcag tagtattttc cccaacatta atacgcgacc ccgataattc cagagacgtt 8340 attgacatga ctgttaagaa ttacagtctt gcgtttttga tagatcatgt acatgaagtc 8400 tttgcctaaa ttcacactat cctttaataa ttcgctcttt tgttttgcac gttcctttat 8460 attctttatt cgtctttttt tgttgtttta gtagttgtac cataactttg ggcagttata 8520 tcgagattcc tttttgcatt tgctaagata gtttcatttt tggtcatttt tagatgtcat 8580 cgtgaaatca gtggcagatg agtgttttat ggatttggcg tatagcttct tcataatgca 8640 ttatcactgc agactgacat ccatcgcttt tatttaatca tttccctgtt ttagtctact 8700 tggcattact cacaatgcta ggctatgaat aaaatgcaat tgcatgtata aaaaaggaga 8760 aatttgtatt tttttttaat tttattatgc tttcaaggat ttaaagaagc attttttccc 8820 aagatcccta acttaggaaa tgctagtgca acgtattgtg agtaagtgat tttgtagata 8880 tatcatgccc attatcttaa tggaattcta aaaaaccaaa agcaattcct ataaacaaaa 8940 attatatacg ttatatggta aattttttga agggggttaa atagagtttc gaacgtctaa 9000 caaaaaacca actcctgttt tactaccact tttttttgag aaaagagggt ctttaagcag 9060 gatattttat tatctatgtg aacaaaatta cggaatttta ctaatggcag atgttattaa 9120 acgatgcatt ttgggcccga ctgaagccgg ctggttcgtc gcaaagtctc aaataaaaaa 9180 accagttgac caaagaccgg ttatcctaac ccattgtaag ctgcacagca aaatgctaga 9240 gccaaaggcg attgtttata aaaaaaattc atctgcaatt cctaaacgag ttgacaacat 9300 tcttcttcga agtcaaaagc ccaaacatat agaatgccta cttgtggact ctaaaatcac 9360 caaaacaagg agccttttga aaagatttgg aagctgtctt gatgaaacta gtaccattgt 9420 acttttaaat caaagtgttt ccttgtggga ggattgctac agtttatttc caaagactga 9480 aaccagaccg cgaatatacc ttggcaggtt ccaaactcta ttcaaatctt ttccatttaa 9540 tttaattagt gattctttca gttatcgtct caaccttagc aaacttcctc gtacaccttt 9600 ggagaagtgt acggtagcta gagcctgtaa acagtttccg ttaaaccaaa ggtccccttt 9660 acttgacttg atgggttcct ttgaaaggga ctatgtaaat ttttcaaatt tttcacagat 9720 gctttctgca cagttatgtg actctatggc ttttttaatt caaatttttc ctactccatt 9780 actcaggcaa aaagctgcga atgcgtggat cgaagtactt tctaaattac catatttcca 9840 tattcttgat aaatcatttt tttctcccca cttgttactt caaagctctg aaaatcaagc 9900 atgcaaattt tttaatattg gtcctcaagt ttatttcgat cctagggaaa gattgcttca 9960 tgttaaggag ttactgaagt tcgctttaaa gcatattgac agtaatgatt ctctatttac 10020 attcttaaag caaacttgtt atacttgtga ttcgccttat gctaaagtgt ttcagcccga 10080 taaacagtcg tttcatagca taatttcaag aaagcgtctt gctcatcttg aaaaggaata 10140 ttttgataag gatgtatcca aattagtgct ttgatttgat atgaggtgaa aaattgaccg 10200 aacatattcc atctactggt aatttaactg ttcaatccgt tctaataaat tcaccataat 10260 ttcgagagaa ggttgttttc aattttttat gttaaaaaga aaaagcaaaa gaaatctagg 10320 gataaaatat cgctaaattt aattcttagc ctgatccaaa agctactgaa gactactgta 10380 tctcagataa agcattgtca attataacca ctcccccatg atgtttcatt cttagtcact 10440 cctttgttta tcttcgagga ttcactcatc tttcaaataa tttgaacacc tatactttgt 10500 tgagattgca aacagcctct attacctttt tattgatcat agatcattaa cttgaaaaat 10560 gttagttata aataacataa aatattacta aaatcatttc attctcatct tttttcacgg 10620 ttttcctttt taggtaacaa tttattgtca cttgaaattc atgaaactcg agtgtataga 10680 agttttcatt tctacaattt aggcgtttcg aagattaagt tgttgtggca tagaatttct 10740 ttaaaagatt acttcttaac ttttagattg aaaagtaaac caacaagcaa atcattagcc 10800 aaatatgtct acagctgaac aattatttgg ggccgaagaa gaagagaagt acgttgacca 10860 agatttgagt gaagatgaag aagatgaacg atttttaaaa gctattcgtt cctcaagatc 10920 aacaaaacca gttgtagacg ttttaaaggt caaatctgaa agctccgccg atgagcttga 10980 ggaacgagat gcccatcttg atcgcttccg gagagattcc acgttcgagt ctgaaacttc 11040 agaccatgaa gacttttcag gcggctctga aaatgagctg gatgaggaga ccacaaaaaa 11100 tgcaaattct ataaaaaaaa tatcacttga agaagttgaa aagcaaagaa aagctattaa 11160 gcgttcagga gttatatatc tttctcgtat ccctccttac atggcaccaa acaagcttag 11220 acaaattctt tctcagtatg gaaaaattgg aagggtatat ttaacacctg agtcatcagc 11280 taagagggca caaaggctga gaaatggcgg aaataaaaga gtaatgtatg aagaaggttg 11340 gattgaattt gaaagcaaac gcgttgccaa atcagttgca gaattgctta atacaaatca 11400 aattggtggt aaaaagagca gttggtatca cgatgatata tggaacatga aatatcttcc 11460 taagtttaaa tggcatcatc tcactgaaca aattgctgct gagaatgccg cccgtgaatc 11520 tcgcctgaag gttgaaattg agcagggtcg caagcagtta aaacaatata tgagaaatgt 11580 tgaaaatgcc aaaatgattg aaggtattcg taaaaagcga agtgaaagag atacactcaa 11640 tgtctctaca gagtttcctg aagaaacaaa agacttatca gaagatacta agccaagcaa 11700 gcaagcccgc cgcttctttg gtcaaaaaag cattgtcagt aatcgtaata tgcccacaga 11760 caatgccaag cagcagaaag ttgaaaacgt tttgcggagg gttttttaat gcttttcatt 11820 tgtgatcttg tagtcttcga aaactacaat tcctttcttt attattgtat tatagtttga 11880 gttgaaattt aagggtttag gttaataata ttttggtgag ttatatgcat tttcatttag 11940 acgttttaca tctttttatt cttccaacaa agagaatggt tactaatatt ttaaaatatt 12000 tgttagccct acaagcatcg ttaccaaact aggtgtaaaa atttttcatt attctaatct 12060 attattaaga cataaattaa ttcttataac ataaaggcat ttgtcggtaa cactcataac 12120 aggtttttat atttgtgtct ttcaacatag aaacacagtc gctgcaaacg ttagaatttc 12180 cgcacgcgcg acattgactt cgccattcca ttaacgaaaa ccttgaatca cacaacgaac 12240 acaattcact agtattatct ttttccaaat gtacgttcga agttgtatct ggcagcatcc 12300 aagaaaatac ttgtcctttg tcatctcctg caaaaatacc tctagcttgg ccgtttggag 12360 taatggtaat aatattttgc cgagttgcaa ccctgttcct gccgagccct ttagtgtgtt 12420 gaagttgtcg taacaaatga aacctccact tcggacgatc agcattattt ttctcagctt 12480 ccaactttgc attcgattgc aaccttttct cccatatacg tatgatcccg tcagggtgcc 12540 ctgttataaa caagttttta tgtaaccact ccgagttcgc tccggtatag aaacaagaac 12600 aaaggatgtt ttcatccgag ttttcattgt aaatccgaga taacttatct ttaacaagta 12660 ttttcccatt gacgttgacc acacagcaat aaaaccctgt ggaaaacgca atttctgcgt 12720 ttctggcatt tacagctatt gtttggatag gcaatttata tacagataac gagctaacaa 12780 actctgcgcg atttaaatcc caaataatca aatttccacc agcatctccg ctcacgatta 12840 tactaaatgc cttgcaaaca gtaacacatg taattctata acggtgacca taaagaaccc 12900 gcttcaagct agccttaatg ggtttattgg tagataatgt ccaaagtctt aaggtaagat 12960 ccaaagacgc tgttaagaaa gttctttcat cacaagcaac 13000 //