ID SPBC1E8 standard; DNA; FUN; 19218 BP. XX AC AL021746; XX SV AL021746.1 XX DT 04-FEB-1998 (Rel. 54, Created) DT 24-NOV-1999 (Rel. 61, Last updated, Version 2) XX DE S.pombe chromosome II cosmid c1E8. XX KW 3-isopropylmalate dehydrogenase; anaphase promoting factor component; leu1; KW phosphatidylserine decarboxylase; retrotransposable element; tf2; KW Ubiquitin family. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-19218 RA Volckaert G., Lyne M., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (03-FEB-1998) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk and Katholieke Universiteit Leuven Faculty of RL Agricultural and Applied Biological Sciences Department of Animal RL Production Laboratory of Gene Technology Willem de Croylaan 42 B-3001 RL Leuven Belgium XX DR GOA; O14333; O14333. DR GOA; O42971; O42971. DR SPTREMBL; O14333; O14333. DR SPTREMBL; O42967; O42967. DR SPTREMBL; O42968; O42968. DR SPTREMBL; O42970; O42970. DR SWISS-PROT; O42971; AN10_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 80% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c1E8 is overlapped at the 5' end by cosmid c16E9. XX FH Key Location/Qualifiers FH FT source 1..19218 FT /chromosome="II" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c1E8" FT /map="IIR" FT misc_feature 1..384 FT /note="nominal overlap with cosmid SPBC16E9, EM:Z99759 FT S.pombe chromosome 2" FT CDS 1..1088 FT /codon_start=3 FT /db_xref="GOA:O14333" FT /db_xref="SPTREMBL:O14333" FT /label=SPBC1E8.01 FT /note="SPBC1E8.01, SIMILARITY:Saccharomyces cerevisiae, FT DPS1_YEAST, phosphatidylserine decarboxylase proenzyme 1 FT precursor, (500 aa), fasta scores: opt: 784, E():0, (46.3% FT identity in 367 aa)" FT /partial FT /gene="SPBC1E8.01" FT /gene="SPBC16E9.18" FT /product="phosphatidylserine decarboxylase proenzyme 1 FT precursor" FT /protein_id="CAA16834.1" FT /translation="LTTLPLRTLSRWWGYVNRIEIPLWMRVPAFGLYSKIFGCNLTEAD FT PDDVRQYKNLAEFFTRKLKPGARVIDPDAPIVIPADGKILNYGVIEGGQLEQVKGITYS FT LDALLGDEKLARLKRSHAIPSPDHIPHIRQEEFAKLNGIHYSLQDLMGHDHGERPSHVK FT DASAQHIDLLSSTKVAAKSQFTLFGSRETNCLYYAVIYLAPGDYHRFHSPTDWVVERRR FT HFSGELFSVSPFMARRLGNLFILNERVALMGRYKYGFMSMIPVGATNVGSIRIKFDKDL FT CTNQFGKLGPVGTFDEAVYTSSSSILHGHPLLRGDEVGNFELGSTVVLVFEAPADFEFL FT VKQGQKVRVGLPLGRVVPSSH" FT CDS 2191..4002 FT /db_xref="SPTREMBL:O42967" FT /label=SPBC1E8.02 FT /note="SPBC1E8.02, unknown, len:603aa, contains Pfam PF0024 FT 0, Ubiquitin family" FT /gene="SPBC1E8.02" FT /product="hypothetical protein" FT /protein_id="CAA16835.1" FT /translation="MSEYRIRVTTVDQKVGIFQVPRTKTVLELKELIAVTFEAPADRLK FT LIHAGRVLRNETPLEEILHDATDLVTFHLVIAVFNSTSTTLPSATSSSVPQSRTSELSS FT TNSIPTPRITSLNPEELSRRERAQRLLQTYNSFHGSGLGGLFPNIHRELESHGFSLPTH FT EQSSPVAESLDNSVSSALSPHLETLRRRNLSIHHQHIQAHEMAQESLETRNPGNISSSS FT APLASDQSPTVSSNHIHASGNLALGSNSGLNPRSPNSFSSPLDNPALHTVDSTNVNGSL FT SPLSNSSSINQVHQNETHGSTISVPNPNLSQMGPSHSSSVPSNLSPNPAQNENPSTTSI FT PSINNQPFPSGLSASNSNFASSSFIPQSVPQLLPIYYQTIFYNGNYYLQQLPSASPPTM FT FRDHSFAPLVSPSIVSPYGVLENEETGECAFLFSPNASQPHFQPRAPTFGIPRNVRSLF FT TLPFFHTIRNIERHFRLFIRLALFCVLTTYNVSLSQTILLTSIMSVVFLLQTGALAPFI FT NDNPLIQSGMRHIRNLQDEYRRRRNRTAQRVVEIPNETQTEDEQDGTNTPDNRADAEER FT ELTRSQRIYRTVVRTIVAFALSFVPRA" FT misc_feature 2200..2373 FT /note="Pfam PF00240, Ubiquitin family" FT CDS complement(4450..5883) FT /db_xref="SPTREMBL:O42968" FT /label=SPBC1E8.03c FT /note="SPBC1E8.03c, unknown, len:477aa" FT /gene="SPBC1E8.03c" FT /product="hypothetical protein" FT /protein_id="CAA16836.1" FT /translation="MVVIANKGALWAYYCKRLLNSVTYMMYPLIRKRTMKKLLLIVGLL FT LACSTVMRRIPLFHESFHLPSLDPRASTTTSQKFQEYRSDFLEKLETAEPPEDVIMFTA FT YGLGVHTHNLFMLACDMAKTSDSQIRFLLLTDGTILPEALYDYNRETVSTCPLSFLSYS FT TGVERLSKELILKDLLSLQFQQALLAISPSVIVTSEHSPLVMFQAINPYLNNNYYTHDT FT VDTNALEENSWITKLDMQSLQHFRTPRINVVLIVEDGTYKYLLNLMRDLGRDFKNSEEY FT PHLFIHLFMSENIPNLSSIRANWPQHRLFINLHFNQKDLNLIEVWTPPNDYTYALVVDL FT QPDSPPQLSSNLITWLKYKILLIYYHKSSSTYKNNIAAIVPSFDFSNEEAVILSQTINS FT NIVLFAPVVFQKFQEYMAVRLLNPNFELPESNGIEFAHEDSVLGHSKPSLTEFHAILGL FT YSLVISYNHFEGSLSNEYV" FT LTR 8941..9289 FT /note="tf2 type LTR" FT misc_feature 8941..13855 FT /note="transposon and LTRs- pseudo" FT CDS 9456..13453 FT /pseudo FT /gene="SPBC1E8.04c" FT /product="transposon" FT misc_feature 10257..10292 FT /note="PS00141 Eukaryotic and viral aspartyl proteases acti FT ve site" FT misc_feature 10761..11300 FT /note="Match to PF00078 rvt, Reverse transcriptase FT (RNA-dependent DNA polymerase) Score 154.95" FT LTR 13507..13855 FT /note="tf2 type LTR" FT CDS 14980..15933 FT /db_xref="SPTREMBL:O42970" FT /label=SPBC1E8.05 FT /note="SPBC1E8.05" FT /gene="SPBC1E8.05" FT /product="serine rich protein" FT /protein_id="CAA16838.1" FT /translation="MKLSFILSTLVAGALAYNEFSAPGPNAVLQEGGGVNTVSWSNLTS FT STVTLTLYRGGNSALTPIETIASDIDNTGTYLWNIATYYEAADDYLLGLSFDGGETYSQ FT YFTLQACSTCTISTSSLSYSGTISSTSIAPSMIGTRTSSSYFITSSSSTPSSSSSSSSS FT SPSSSSSKSSSSSKSSSSSSSSSKSSSSSSSSSKSSSSSSSSSKSSASPSSSKSSSKFS FT SSSFITSTTPASSSSSGAIVSNAKTASTDDSSSASSATSSVSSVVSSASSALSASASSA FT SASVSSSASSDASPALKTGINALVAVGVVSAIALFL" FT misc_feature 16193..19218 FT /note="nominal overlap with cosmid SPBC1A45P, EM:AL031174 FT S. pombe chromosome 2" FT CDS join(17433..17599,17671..17997,18056..18131) FT /db_xref="GOA:O42971" FT /db_xref="SWISS-PROT:O42971" FT /label=apc1 FT /note="SPBC1E8.06, len:189aa" FT /gene="SPBC1E8.06" FT /gene="apc1" FT /gene="SPBC1A4.01" FT /product="anaphase promoting complex subunit" FT /protein_id="CAA16839.1" FT /translation="MAQIRQEALKKQKSETQKSTEGFVDIGNLAQWTCSSEKSGFPIRL FT VRDDNIDTYWQSDGSQPHTIHIKFVKRVSIKYVSMYLQYTLDESYTPSTLRISAGTGFQ FT DLEIVTTVQVEEPTGWVHVPVGDFGRNGLLDVHLIQIKILANHQSGKDSHVRLIKIYAP FT EIEQPAIAVDEIPYTSLQFISRNQLR" FT misc_feature 17600..17605 FT /note="gtaagt, splice donor sequence" FT misc_feature 17644..17670 FT /note="ctaactataattttctttgtctttaag, splice branch and accep FT tor" FT misc_feature 17998..18003 FT /note="gtacgt, splice donor sequence" FT misc_feature 18041..18055 FT /note="ctaacactgatgcag, splice branch and acceptor" FT CDS complement(18554..19218) FT /codon_start=3 FT /label=leu1 FT /note="SPBC1E8.07c " FT /partial FT /gene="leu2" FT /gene="SPBC1A4.02c" FT /gene="SPBC1E8.07c" FT /product="3-ISOPROPYLMALATE DEHYDROGENASE" FT /protein_id="CAA16840.1" FT /translation="SGYAMDTWPYSLEEVSRIARLAAWLAETSNPPAPVTLLDKANVLA FT TSRLWRKTVAKIFKEEYPHLTLKNQLIDSAAMLLVKSPRTLNGVVLTDNLFGDIISDEA FT SVIPGSLGLLPSASLSGVVGKSEEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLL FT RYGLNAPKEAEAIEAAVRKVLDDTSIGGRGLYTRDLGGEASTADITKAVVEELEKIL" FT misc_feature complement(18581..19210) FT /note="Match to PF00180 isodh, Isocitrate and FT isopropylmalate dehydrogenases Score 384.92" FT misc_feature complement(18878..18937) FT /note="PS00470 Isocitrate and isopropylmalate dehydrogenase FT s signature" XX SQ Sequence 19218 BP; 6308 A; 3594 C; 3263 G; 6053 T; 0 other; tccttaccac tttaccatta cgaactctct cgcgttggtg gggatatgtt aatcgtattg 60 agattcctct atggatgaga gtgccagcgt ttggccttta ttctaaaata tttggttgca 120 acttgacaga agctgacccc gatgatgtcc gccaatacaa aaatctggcc gagtttttca 180 ccagaaagtt gaaacctgga gcgcgcgtaa ttgatcccga tgccccaatt gttattcctg 240 cggatgggaa aatcttgaat tatggtgtta ttgaaggagg tcagcttgaa caagtaaaag 300 gtataaccta ttcccttgat gcactattgg gcgatgagaa gttagctcgt ttgaagcgca 360 gccatgctat tccctctccc gatcatatcc ctcacattcg tcaagaggag tttgccaagt 420 taaatggtat acattacagt ttacaagatt taatgggtca tgatcatggt gaacgaccaa 480 gccatgtcaa agatgctagc gcacaacata ttgatttgtt aagctcaaca aaagtggcag 540 ccaaatcaca gtttacgttg ttcggatcaa gagaaacgaa ttgtttatac tacgcagtta 600 tttacttggc accaggtgat taccatcgat ttcattcgcc gactgattgg gtcgtagaac 660 gaagaaggca tttttccgga gagctgttta gcgtttctcc ttttatggct cgtcgactcg 720 gaaatctttt catcttgaac gaaagagtag ctttgatggg gagatacaaa tacgggttta 780 tgagtatgat acccgtcggt gctacaaatg ttggcagtat ccgaattaaa tttgataaag 840 atttatgtac gaatcagttt ggaaaactag gcccagtagg tacttttgat gaggctgtat 900 acacctcatc ttcttctatt ttgcatggtc acccattact tcgtggagat gaggtcggaa 960 attttgagct tggtagtaca gtggtattgg tgtttgaagc acctgcggat tttgaatttt 1020 tggtcaaaca agggcagaaa gttcgtgtgg gattaccttt gggtcgagtt gtcccatctt 1080 cccattaata aaagagatga acactcatat tttagattgt ggatttccca tatgtttaat 1140 tttattttca ttgtcttttt gttgaaatct acaaacttaa gggattttat cttggaattt 1200 ctttgtttca atatagcaag caatgcatat tggtataaac ttgttgtatt aaaaggacgg 1260 actggataaa acgagaagaa atgaatctat tcgtcaacgt aattatgata atccaatgta 1320 atattaagtt aggaaaaata cacaaattaa aatatgtaca tgcactaaat tacaaccact 1380 ccaccttgaa gtagtcgtac tcaacggcat ctcagatttt tatagtctca tttaattagc 1440 catacaatta aatatcgcta atctcaactc aatcctcatc ataaaaaaat ataaggagag 1500 tttgatggag acagagtaga tttactcgtt tcaagttttt ataattacaa ggtccaatga 1560 gctgagaaca aaggtattta atattattgt atttgtacag atgccaaacg atagttttaa 1620 taaactatca attagaacat aagattgtta gctacacata gttggtggaa gtttaatttt 1680 tcaagtcagt ggaatatata aaagcacact agtgcaatac tgagaagtac agcatttttc 1740 gtaatacact ttgcatgtat gattaatttt tttatctcta ccggtaattt tatgagataa 1800 ataatttgaa ttcacttttt aaatgagttg ttttctaaca agaattcctg ggaagtatgc 1860 tgcgaagttt gtcaagatcg ctctgtgttg ggatgaattt gaatggattt tctcagccaa 1920 tatagcgttc tgactaccta caattagaag aacgaaagaa taagattaaa agattccctc 1980 ccttttattt cagaatgttt acttcttcta acgactatat agcaggcaat gttcactgtg 2040 agaaaacaca ctcgatttag tgaagtacag agatacgcta tttactgcgt gtgattcgtg 2100 ccgctcaaca ttccttcaag tgattcctaa cattgctgta cattctcttg aaaagcgttt 2160 taaccttttc aattctgaaa cttgtaaaga atgtcagagt atcgtattcg agtgacaact 2220 gtggaccaga aggttggtat ttttcaagtt cctaggacaa aaacggtttt agaattaaag 2280 gaactgattg ctgtaacatt tgaagctcct gcagatcgat taaagttgat tcacgctggt 2340 cgtgtattga ggaatgaaac tcccctcgag gaaattttgc atgacgctac tgatctggtc 2400 acttttcatc ttgtaattgc ggtttttaat tctacaagca caaccttgcc atcagcgaca 2460 tcatcttctg ttcctcaaag taggaccagc gaattatcat cgactaattc aattccaact 2520 cctcgaatca ccagtttgaa cccggaagaa ttgtcaagac gtgaacgtgc ccaacgttta 2580 ttacagacat acaacagttt ccatggatct ggcttaggag gactttttcc aaacatacac 2640 cgggaactag aaagtcacgg attttcattg ccaacccatg agcaatcatc acccgttgct 2700 gaatctctgg ataattcggt atcgtctgct ttatctccac atttggaaac gctgcgtcgc 2760 cgcaatctca gtattcatca tcaacatata caagctcacg aaatggcaca agagtccttg 2820 gagaccagaa atccaggaaa catttcttcc tcgagtgctc ctttagctag tgatcaatcc 2880 ccgactgtat catctaacca tatccatgca tccggtaatt tggctttagg atcaaattcg 2940 gggttaaatc cacgaagccc taattctttt tcttccccat tggacaatcc tgcacttcat 3000 actgttgact caaccaacgt caatggttcg ctttcacctc tatcaaattc ttcatctatc 3060 aatcaagttc accaaaatga aactcatggt tctaccatct cagtacctaa cccgaactta 3120 agtcaaatgg gcccttcaca ctcttcttct gtgccctcaa atctgtcacc aaatcctgcc 3180 caaaatgaaa atcctagtac aacctctatt ccatcaataa ataatcaacc attcccgtct 3240 ggtctttctg cttctaactc taattttgcc tcttcctcgt ttatccctca gagcgttccg 3300 caactattgc ctatatatta tcaaactatc ttttacaacg gtaactatta tttacagcag 3360 ctcccatctg catcgcctcc cactatgttt cgagatcact catttgctcc tttagtttcc 3420 ccttctattg tttctccgta tggtgtttta gaaaatgaag aaactggcga atgtgccttt 3480 ttgttttcac caaatgcctc ccaaccccat tttcagccga gagcccccac gtttggcatt 3540 ccacgaaatg tgagatccct cttcacctta ccgttcttcc atactatccg taatattgag 3600 agacatttcc gattatttat tcgtttagcc ctgttttgtg tattaacgac ttataatgtt 3660 tctctctcac aaacaatttt gctaacatct ataatgtctg ttgtgttttt gttacagacc 3720 ggtgctctag ctccattcat caatgacaat ccactcatcc agtctggtat gcgtcatatt 3780 cgtaatcttc aagatgaata ccggcggcgt cgaaaccgaa cggctcaaag agtagttgaa 3840 attcctaatg agacacagac tgaagatgaa caagatggta caaatacgcc ggataatagg 3900 gctgacgctg aagaacgcga actaactcga agtcaaagaa tataccggac ggtagtaaga 3960 accatagttg ccttcgcatt aagctttgta cctcgagcgt aacatttttt tcttaaaaac 4020 aaaagtgata atatagctgt aaagtcattt ttcattacta attagaaata ttgtctaagc 4080 ttgctattaa taaaagagtt ctagctagac taaattttga cagtgtcgaa atatcattcc 4140 aaggtacccc atcagattaa caaatttata aacatatatg caaatataaa ttgcagaata 4200 gtataattca tagaaaaaac aattaacaag cttacattag gggttcacaa aatatagaac 4260 gaataggaaa agagcttaaa ctgccataat aagggcacga agtgacggaa ttatacaatt 4320 ttttggattc gttttttgca ccttggaaac ttagtctttt gctgtcgtaa gtaaaataaa 4380 gatttttttc ggaaatctcc tcgaaattaa taacagatgg attcttcaaa aagtaagcaa 4440 ttaaattgtc taaacgtatt cgttgctcaa gcttccttca aaatggttat aagaaattac 4500 taacgaataa agacctaaaa tggcatgaaa ctctgttaaa cttggttttg aatgtcctaa 4560 aacagagtct tcatgagcaa actctatacc atttgattcg ggaagctcaa agttaggatt 4620 caataatcga acagccatat actcttgaaa cttttggaat acaacgggag caaaaagaac 4680 aatgtttgaa ttaatcgttt gagaaagtat caccgcctct tcattagaga aatcaaaaga 4740 aggaacaata gcagcaatat tattcttgta agtggacgac gatttatgat aataaattaa 4800 tagaatttta tacttaagcc atgtaattag attcgaagaa agttgtggtg gggagtccgg 4860 ttgtaaatcg acaacaagag cgtacgtata atcattcggt ggtgtccaaa cttcaatcaa 4920 atttaaatct ttttgattaa aatgcaggtt aataaaaagc cgatgttgag gccaattagc 4980 acgaattgaa gaaagattag gaatattttc ggacataaag aggtgaatga acaaatgtgg 5040 atactcttcc gaattcttga agtccctacc caaatctcgc attaaattta gaagatactt 5100 gtaagtacca tcttccacaa tcagtacaac atttattctg ggggtacgga aatgctgcaa 5160 tgattgcata tccaactttg ttatccagct attctcttca agagcattcg tatcgactgt 5220 atcatgagta taataattat tgtttaggta aggatttatc gcctgaaaca tcactagtgg 5280 agagtgctcg gaggttacga taacgctggg agatatagcc aaaagggctt gctgaaactg 5340 caaagaaagc aggtccttta aaattaattc tttcgacaga cgttctacac ctgtactata 5400 ggaaagaaaa ctcaaaggac atgtcgaaac agtttcacga ttataatcgt acagagcttc 5460 tggtagaatt gttccgtctg ttaacaaaag gaaacgaatt tgggagtcgg atgttttagc 5520 catatcacaa gcaagcataa aaaggttatg agtatgaaca cctaatccat aagcggtaaa 5580 catgataaca tcttctggag gttcggcagt ctctagtttt tctaaaaaat cgctcctgta 5640 ttcttgaaat ttctgggacg tagtggttga agcacgagga tctagtgagg gcaaatggaa 5700 actttcatgg aaaaggggaa tgcgtctcat tacggtgcta caggcaagaa gtaaaccaac 5760 gattaataaa agctttttca tggtgcgttt cctaattaat ggatacatca tatatgtaac 5820 tgaatttaac aatcttttgc aatagtaagc ccaaagcgca cccttgttag caataacaac 5880 catgaagcga taacttaagt tccgtaagag aaaataagaa aggagaatga agaaagaaaa 5940 aaaaaacgaa aggaccaatt ttaaatatgt acagcaccaa gatgagtcct gtccgaaagt 6000 aaaaaaacca cttcgaggac acacgtaaac aagggtaatc taaaaacaaa gaataggctc 6060 gtctattgag cgatactatc caatccaaac acttttaaaa ggattattaa gaaaatatac 6120 aatttacgat ccctttgttt cgtattaaca cttcgtatcg atcaaataaa aaatccttac 6180 tattctttca aacaaagaac gtactgtatc acattcaatg ttacactgat ggagttatta 6240 tcttatttga acagcagaca taaaaaattc gaaacttttc aaaaagagga aggaaagaaa 6300 tcgatacgaa aggtaaaaaa tagtggaaat caggcggact ccaaacgcca gatacaaaca 6360 cggatattag taatattaag cagggaaacc gagctggatg tttattcctt agctatataa 6420 aactaatatt taatattaag cctttattac cactttacca agcctaagag agaaaactcg 6480 gtgtttattg gaaaagtggt actaacaagt gtgggaagta tgtttgacag attcattaca 6540 ttagaggcag tcagccaagc gtataaataa ggggtatgca cttgtccgaa tatcacgctt 6600 tacaattgaa aagttacaaa ttcaagtttt tactaaaaag aattctttcc aatcgagttg 6660 gatggaaacg tgttatgtgc gagtcagtct gtgtatacta catgaatcaa ccgcattggc 6720 gttgaagcga aaggaaaaag agtactataa tattatattt gcgactgaag tttaagagat 6780 aattgatttt gattatacgt aaaaagagca agctgttgta gtgagaggaa gaacaacttt 6840 taaacagacg taaataagat tctttctgta aggttagcat atttaaaaca gtaattttaa 6900 ttttttaacc ttaattagct tttcattctg tctttgtggg tttatttgcc aagtgcatta 6960 gccagcacaa tgtatttaaa cagactggtc ttttgatcaa aagtcattgc aatatgatca 7020 aaaccgtcga gacttcataa cggctattaa aagcaactcg cttaaaaaaa aacagatgaa 7080 taaatttcaa attgtcattt ttcatacgaa cgacatactt cttgacgcaa agcaatgtca 7140 gtgtgcatag aagacatatt ttgaagatgg agaaagtttc aaaatttgga accctcaatt 7200 ttacatattt ttacattttt gagtaagatt ttctggtctt tagaatgaat cccacccgtg 7260 tttgaatgaa cgagttcaga tcaataatga aacacaatgt taaattttgg attaattgcg 7320 aaataacaga taaccttgta cctataggaa attcataaaa gatttatatc ctttctcgtt 7380 ataggtgata ctatttccat atgttgaaag ctttgaattt tcatctttaa gtatttgcgt 7440 ctatccacat tagcaatgtc aatttttcct ttatatgtaa atatttttac ctcgatttaa 7500 tgcatttagt agtacttcat atgctgtagc acctttcagg ataatagttc acactatgac 7560 attcaaatat ttacccaccg aaaatatttt tcgctgaaca gtgttataaa taatttgtta 7620 aataaataaa aagaaaaaaa agatggttaa aaaaatagat taaactggca atacagacgc 7680 tggtggagaa tatctcatgg aagtatatta acaaaacttg cagatgctac attactcaat 7740 tcatgactgg ttgatataaa gtcaattatt gacaagtcaa acttcaattt cttcttatac 7800 gcagtacatt aaatcaggta cgcgcaatta aagttactag ctgttcattt ttgttaactt 7860 tatatacgct attatgattt cagaatttga gctgcaataa tagattgttc attatctatg 7920 ttttattacg gtatacaaat cttgaatagg cgacacagtc aattcaaatt gaaattttat 7980 ctcaattgag ttttataaca aatgttgaaa ccaaaaaaaa aaggtattta atcaaacgaa 8040 ctgtgaaact ctcaaaaaaa ttaagaatta ggcagattgc actttgtttt ataggaaact 8100 tgttacactg ggtttttgta ttgttttcgc ctaatccaat gctgaatttt tatgatctta 8160 acagcttcct tttttctttt tttttttttt atttacactc gatcctcgtc ttttcgctgt 8220 ttcatcaatc caacagatta gccaattatt gtataatatc tttatatttt attttttgat 8280 ctgccttttt attttgaata gaacaataaa agtaaggaaa atatcaaaaa aaaaacagaa 8340 aagaagtaag aaatagttta gagcttttaa cgaaacctcg acagctacgt gattaatcat 8400 tttcatatga gtaagcatgc aatgcaatgc aaacatcagc ggattgttta tatatgtata 8460 tccatatata aatgtaaaaa agtaaataaa atctagagat atgagtggat taagaaagaa 8520 aaaaccgagg aaattaaaaa acaactttag taacaattac attccttaaa aaacgctgat 8580 tattcttaac gatttagcat tagttaaaca aatctcaaaa attaactttt acattgaggt 8640 tgaatctagc ttgtgtaaga gattccaagg ttactgtttg tatcatcaca tgagtctaaa 8700 aaattgcttt aataacttat gtaactctta gccgtctaag gctttcttta ccttacactc 8760 aacacatcct ctgaaattca taaaccaatt tatttgatcc tataacgaag cgcttggcaa 8820 gtttgcgtag ctttcgccaa cgctgctacg ttcattttcg ttgtatatat taccataaca 8880 gccatacgat ctgtatacgc tttaaggatt agtaaaccaa agagaataga aggactataa 8940 tgtcagcaat actacactac gctataatac actacgttga gtatcactat atgtcacatg 9000 ttctaattat atatcgtacc atgtatgata cgatatggag attgatctta atgataatct 9060 attaagatca atattatctg aatactataa atagagctac tgctgaacct cgttcctcag 9120 ttcagttatg agctatatta gtgataggta acattataac ccagttaata caatacctat 9180 actcagttgc tacttataca acctgtgtat tgtaatataa tagatcacaa ggaaagctca 9240 ccgcagttct acgtatcctt aaatcagata ccaaactgcg tagcttacaa taactgaact 9300 cttgtgatct acaattaact ccttttagga aaaaggaatt attgaataaa tatatatcat 9360 aaatatatat atttctctcc ttctgggttc aaaggagaaa gaactttgga aggactgtta 9420 tcccttttga aatctcccaa agggaaacat atacaatgtc ctacgcaaat tatcgttata 9480 tgaaagcaag agcaaaacga tggagaccag agaatttgga tggaattcaa acatcagacg 9540 aacatttaat aaaccttttt gcaaaaatat tatcgaagca tgtaccagag atagggaaat 9600 tcgatcctaa taaggatgtt gaaagttaca tttcaaaact tgatcaacac tttactgaat 9660 acccttcatt attcccaaat gagcatacta aaagacagta tacattgaat cacctagaag 9720 aattagagca acaattcgct gaacgcatgt tttctgagaa tggaagtctt acatggcaag 9780 aattactcag acaaacaggg aaagtacaag gatccaacaa aggtgatcgt ttaactaaaa 9840 catttgaagg ttttagaaat caattggaca aagttcaatt tataaggaaa ctcatgtcaa 9900 aagcaaatgt tgatgatttc catactcgct tgtttatatt atggatgctg ccatattcct 9960 taaggaaatt aaaggaaaga aattactgga aatcagaaat cagtgaaatt tatgactttt 10020 tagaggacaa aagaacagct tcgtatggta aaattcacaa gcgttttcaa ctgcaaaata 10080 aaaatctagg aaaagagtcc ctttcaaaga aaaataacac cactaatagc agaaacctga 10140 ggaagacaaa tgtttcgaga atagaatact catctaacaa attcctaaat catactagga 10200 aacgttacga aatggtatta caagctgaac ttccagactt caagtgctca ataccctgtc 10260 taatcgatac gggcgctcaa gcaaatatta taacagaaga aactgttcga gcacataaac 10320 tgcctaccag accctggtca aaaagtgtga tatatggtgg agtttatcca aataagatta 10380 atcgcaaaac aataaaactt aacataagtc taaatggaat atcaatcaaa acagaattct 10440 tggttgtaaa gaaattttcg catccagctg ctatctcctt cacaacatta tatgacaata 10500 acattgaaat atctagcagt aaacacacgc tctctcaaat gaacaaagtt tcaaatattg 10560 tcaaggaacc tgagttacca gatatctata aagaattcaa agacattact gcagaaacca 10620 atacggaaaa gctaccaaag ccaataaaag ggttagaatt tgaagttgaa ctaactcaag 10680 aaaactacag attacctatc agaaattacc cgctaccacc gggaaaaatg caagctatga 10740 atgatgaaat taatcaagga ttaaaaagtg gaattatacg agaatctaaa gccattaacg 10800 cctgtccagt aatgttcgtt ccgaaaaagg aaggcacctt gagaatggtg gttgactaca 10860 aacctttaaa taagtatgtc aaacccaata tatatccgtt accacttatt gaacaattac 10920 ttgctaaaat acaaggttct acaattttta ctaaacttga cctcaaaagt gcctatcact 10980 tgatacgagt aagaaaagga gatgaacata aacttgcttt tcgctgtcct cgtggagttt 11040 ttgaatatct agtaatgcct tatggcatat ctacagctcc agcacatttt caatacttta 11100 tcaatacaat acttggtgaa gccaaagaat cacatgtagt atgttatatg gatgatattt 11160 taattcattc aaaatcggaa tctgaacatg taaaacatgt taaagacgtt ctacagaaat 11220 tgaaaaatgc gaacttaatt atcaatcaag caaaatgtga atttcaccaa tcacaagtaa 11280 aatttatagg gtatcacatt tcggaaaaag gatttacgcc ttgtcaagaa aatatagaca 11340 aagtcttaca atggaagcaa cctaagaatc gtaaagaatt acgacaattt ctaggttctg 11400 tcaattatct taggaaattc attccaaaga catcacaatt aacacatcca ctcaataatc 11460 ttttgaaaaa ggatgtacgc tggaaatgga caccaacaca aacccaagcg atagaaaaca 11520 ttaaacaatg tttagtttct ctccggtgct acgacacttt gatttcagta aaaagattct 11580 actggaaact gatgcttcag atgtcgctgt aggagccgta ttgtctcaaa aacatgatga 11640 tgataaatac tatcctgttg gatactattc agcaaagatg tctaaagcac aattaaatta 11700 tagcgtatcg gacaaagaaa tgcttgcaat cattaagtct ctcaaacatt ggagacacta 11760 tttagaatcc actatcgaac ctttcaaaat tttaacagac catcgaaact taattggtcg 11820 cattactaac gaatccgagc ctgaaaacaa acgtttagct cgttggcaat tatttttaca 11880 agacttcaac tttgaaatta actacagacc tggatcagca aatcacatag ctgatgcctt 11940 atccagaatt gttgacgaaa cagaaccaat tccaaaagat tcagaagaca atagtatcaa 12000 ctttgttaat caaatctcga taaccgatga ttttaaaaac caagtggtta cagaatatac 12060 gaatgataca aaattgttga atttactaaa caatgaagac aaacgagtgg aagagaatat 12120 ccaactcaaa gatggcttac taattaacag taaagaccaa atcttattac ctaatgatac 12180 tcagctgact aggacaatta ttaaaaagta tcatgaagaa ggtaaattga ttcatccagg 12240 cattgaactt cttacaaaca ttatattacg tagatttacg tggaaaggaa taagaaaaca 12300 aatacaagaa tatgtacaga actgccatac atgtcaaata aacaaatcta ggaatcataa 12360 accttatgga cctttacaac caattccccc atcagaaaga ccttgggaat ctttatcaat 12420 ggattttatt acagctttac cagaatcatc tggttataat gcacttttcg tggtagttga 12480 ccgattttca aaaatggcaa tcttagtacc ttgtacgaaa tccattacag cagagcaaac 12540 agctcgaatg tttgatcaac gagttattgc ttatttcggc aatccaaaag aaatcattgc 12600 agataatgat catattttta cttcccaaac gtggaaagat ttcgcacata aatataattt 12660 cgttatgaaa ttttcgttac catacagacc acaaactgat ggacaaactg agcgtacaaa 12720 ccaaactgtg gagaaattac taagatgtgt atgtagcaca catccgaata catgggtaga 12780 tcatatatcc ctagtgcaac aatcttacaa caatgcgata cattcagcaa ctcaaatgac 12840 accttttgag atagtacatc gctattcacc agctttatca cctttagagt tacctagctt 12900 tagtgacaaa actgacgaaa actctcagga aacgatccaa gtatttcaaa cagttaaaga 12960 acacttgaat acaaacaaca taaagatgaa aaagtatttc gatatgaaaa tacaagaaat 13020 tgaagaattt caacctggag acctagttat ggtcaaaaga acgaaaacag gttttcttca 13080 taaatccaat aaattagcac ctagttttgc aggaccgttc tatgtgttac agaagtcggg 13140 tccaaacaac tatgaattgg atcttccaga ttcaatcaag cacatgtttt catctacttt 13200 tcatgtttct cacctagaaa agtatcgaca taattcagaa ctcaattacg ctaccattga 13260 tgagtctgat attggaacaa ttcttcatat cctagaacat aaaaacagag aacaagtact 13320 ctacttaaat gtcaagtaca tttcgaatct aaatccgagt actattatgt caggatggac 13380 tacattagct acagcgctac aagcggacaa agcaattgtc aatgattata ttaaaaacaa 13440 taatctaaat atctgagaac atatgactta tcctcagatt tacatagaaa atcttgggga 13500 gggcaatgtc agcaatacta cactacgcta taatacacta cgttgagtat cactatatgt 13560 cacatgttct aattatatat cgtaccatgt atgatacgat atggagattg atcttaatga 13620 taatctatta agatcaatat tatctgaata ctataaatag agctactgct gaacctcgtt 13680 cctcagttca gttatgagct atattagtga taggtaacat tataacccag ttaatacaat 13740 acctatactc agttgctact tatacaacct gtgtattgta atataataga tcacaaggaa 13800 agctcaccgc agttctacgt atccttaaat cagataccaa actgcgtagc ttacatataa 13860 actggtttag cagtatgcgg taaaaattct aatattactt acaatcctgt cttatacttc 13920 gttattagca aaaggaattt attagtattc tagtaaatgg tagtatatca tgtcgatagt 13980 ttagcaacag agaagtagag ttccgtagct tgataacgcc acgctcattg gtgtttctag 14040 tccagcaatg aatattgctg gaaaagatca gttacgtaaa ccggaattga agtgatgtgt 14100 tagagaatag aattgctggt ataccacaga acgggctgtg tatagcacag tacgttacac 14160 accattatac accttaaaac cttatccctc caattcacta tgttgttcgc tgagctagcc 14220 aggatggttg cgattgtttt gtcataattt aatttcgtga tttttgcaaa caaatgacca 14280 atttcttctt gctttctcta attttaaaat tgaatggagt gatacatcac caaaatattc 14340 catcgtcttc tctcacttgt ttcccttcct tttcccataa tgtctgagat ttgtttacat 14400 ttgaatgaat ctttgtttac atctgagcga atctttattt acattaagtg atggagtgta 14460 tacgggttta cccggttccc agttagttac cctgacaacg cgttctcatc gttaccttag 14520 cggactcgtt acttacgttg cgaggtggct caggtgcaag aaagccacct ccctgaccca 14580 ctcacgacgc taaatccgtg tcacatgacc attcgttact tgaggggttt ttcaaatata 14640 aaaggaaagg atgccgcagc aaatttctac tcagacccaa ctacgagtat tcatttttga 14700 tatttttact tgtgagttta atttccgtcg ttggacttga agctccttta tctgtcttta 14760 tatatattca ccgatcacta atttcgttcg atcctttagc aaaatttcat tcgttcgaaa 14820 acggaagatt ttttcattaa cacctttatt tatctttcat ttctttggta ataaaatttc 14880 tcattgattg cattcatcta tctatctaca tcccatccat ccatattatc tgtctttttt 14940 tccaactttc acatacttac ataatatcat ctatccatca tgaagttgtc tttcatttta 15000 tctactctcg tcgccggcgc tttggcatac aatgaattct ctgcccctgg acctaatgcc 15060 gtccttcaag agggtggtgg tgtaaacact gtttcttgga gcaatttgac ttctagcact 15120 gtcactttga ctttgtaccg cggtggtaac tctgcactta ctcctattga gaccattgct 15180 tctgacattg acaacaccgg tacttatctc tggaacattg ctacttacta cgaggctgct 15240 gatgattact tgcttggtct tagctttgac ggtggtgaga cttattctca atactttact 15300 ttgcaagctt gctctacttg tactatctcc acttctagcc ttagctacag tggtaccatt 15360 tcttctacct cgatcgctcc ctctatgatt ggtactcgta cttcttcctc ttactttatc 15420 acttcctcct cctctactcc ctcctcttct tcctcttcct ctagctcctc tccctctagc 15480 tcttcttcca agtccagctc cagctccaag tctagctctt cctccagctc cagctccaag 15540 tctagctctt cttccagctc tagctccaag tccagctctt cttccagctc tagctccaag 15600 tctagtgctt ctcctagctc ttccaagtct tcttccaaat tctcttcttc tagctttatt 15660 acctctacca ctccagccag ttcttctagt agcggtgcta ttgtttctaa cgccaagact 15720 gctagcactg acgactctag ctctgccagc tctgccactt ccagtgtatc cagcgttgtc 15780 agctctgcta gctccgctct ctctgcatct gcttcatcgg cctctgcttc tgtttctagc 15840 tccgcctctt ctgatgcttc ccctgctttg aagactggca tcaatgcatt ggttgctgtt 15900 ggtgttgttt ctgctattgc cttgtttctt taattgtggt atcctagagg tatgatgaat 15960 agctggtagg gtttaaaata aatttgcttt tctctctctt tagccctatc tttaaattac 16020 aaattttttt ctttatttca ttcatctaat caccacttac ttttattcat cacaattttg 16080 acatgacgta tctttttttt gatatttttg gtcgtcgttt tcattagtat caactttttt 16140 ttatattttt ttgcatttca ttttgtctca tattcaattt tttttcaact ttgatcatca 16200 ttgctttgcc agtgtgttgt gtttattgtt tgtaaatctc taaaactctt ttcgatgatg 16260 gtatttctcc aatggtgtac tgatgatggt aaaatttaac atttatgtga catggttctc 16320 ttctgtaaat gttttgcagc gtactattgt tttatcattt ggaaagtatg gtgtgcttgc 16380 atgaagtctg gaggttgtac aaatcttttt gttttggggg catctggatg tttgtcgcac 16440 tcgtattttg tacggtgaca atttcgataa gtcttttatc atctgtgccc gatatgttgg 16500 aaatgttgaa taattggata tcaatgtgca attacagtat aaggaagact ttgaattctg 16560 tttgtctata aagttgcgtt tgactgcaaa acattgaata tttacagtcg gtttactttg 16620 tatacaaaaa tgtgtaatcc ttttacttta cgaatttacg ttcgcttgtc ttactgaatc 16680 tatctatagc ttggaccacg acgggtgctt tgaagggttg gctgctaata attcttcttt 16740 gatctaatcc agtataactt cctatttcgg cattcaaaaa gtctatagag ttctgtaata 16800 tcgcgaattg gttcatcttg gcaagacaaa ttgctcatta ctttgtaaat caatataatt 16860 caaacactgt gtctttcata aaatgacttt tttgcattcg cataagtgta ttgatctatc 16920 tttctttctt ttttagcttt ataataaaac aatgaatact gcatgatata agcgttacac 16980 aattcttttt ccctactgct gcaataagtc ttttaaagaa gttggattta agccaacaat 17040 agacaggtat atctgtgtat gttgagtcaa taaaaactaa aaagcctgtt tatctgtagt 17100 actataactt acattgtttt tctggtttga atatatatta acgaactatt ctattagtaa 17160 tgtatgctca caacgagtac acgtcgctct ttacgttcca taaaaggtac ttgattcttc 17220 agctaaccag cgctagactt ttttattagt atatcagagg agtgaatttt tgaaacttgt 17280 gcactcgaca ttattctcta acaacacttt attataatta ttgagaaccg tttaatggtt 17340 gtatagcgta cacatttgta aatatagata aggaagcctt gggaggacgt tatgtcaaca 17400 tctcacaagt ccgcattgtt tacatttagc ttatggcgca aattcgacaa gaagcattga 17460 aaaaacaaaa gtctgagacg caaaaatcaa cagaagggtt cgttgatatt ggaaatttgg 17520 ctcaatggac ctgctcgagc gaaaaatccg gatttcctat acgcttggtg cgggatgata 17580 atatcgatac atattggcag taagtgtatt tgtataaata tagtcaggga agaaaatgtt 17640 ttactaacta taattttctt tgtctttaag gtctgacggc tctcaacctc ataccatcca 17700 tattaaattt gtaaagcgag tatcgattaa gtatgtgagt atgtaccttc aatacaccct 17760 tgatgaatct tatactccca gtactttgcg aatatcagct gggacagggt ttcaagattt 17820 ggaaattgtt acaacagttc aagtcgagga accaactggt tgggtacatg tgccagttgg 17880 tgattttggg cgaaatggct tgttagatgt gcatttaata caaatcaaaa tacttgcgaa 17940 ccatcaaagt ggaaaggata gtcatgttcg tttgataaaa atatatgcgc cagaaatgta 18000 cgtattttgc atagcaaaat cttcattaat ataaaatgtg ctaacactga tgcagagagc 18060 agcccgcgat agctgtggat gaaattccct acacaagttt acaattcata agtagaaacc 18120 aattacggta atgcaaaagt catgtctctg gctctctcaa agaatcgggt tgtcatcgtt 18180 acaataataa ttgttacgtt ctcgaatttt tatggttttt ttcttctttt cccctattat 18240 ttatgttaca ggttacttcg tttaaaaaga aataattaat gatattatgt ttgaaacttt 18300 tcatagtaaa aaaagagtaa gtacacagcg acaactcggt cataaagttg aacggatgtc 18360 gtaaatcaat tccatgcttt tgcaacttaa tacatctttg cttgactata acataccaaa 18420 agaaaaaaca ttagagcctt aaaatttacg cttttgtcaa ttgcattttt aacgataata 18480 aatatgcgac acaattaatc aataaaaatt aggtcaaatc aaatcatatg aatttattct 18540 acattaaacc ctattacaaa attttttcaa gttcttcaac aacagcctta gtaatatcag 18600 cggtagaagc ctcacctccc aaatcgcgag tataaagacc acgtccacca attgaagtat 18660 catccaagac cttgcgtacg gcggcttcga tagcttcagc ctccttagga gcattcaaac 18720 cataacgaag gagaagggaa gcagataaaa ttgtaccaac aggattaaca atgcccttgc 18780 cagcgatatc gggagcgcta ccgtgaatgg gctcaaccaa acaatgaacc ttttcttctg 18840 attttcctac cacaccggaa agggaggcag aaggcaaaag gcccaagcta ccaggaatga 18900 cagaagcctc atctgaaata atgtcaccaa acaagttgtc agtcaaaaca acaccgttaa 18960 gtgtacgagg gctcttgacc aaaagcatgg ctgcggagtc aatgagctgg ttttttaagg 19020 taaggtgagg atattcctcc ttaaaaatct tagctacagt cttgcgccaa agacgagaag 19080 ttgccaaaac attagctttg tcgagtaatg tgacgggagc aggagggttg gaagtttcag 19140 ctaaccaagc agccaaacga gcaatacgag aaacttcttc caaactgtaa ggccaagtgt 19200 ccatagcata acccgatc 19218 //