ID SPBC1D7 standard; DNA; FUN; 18000 BP. XX AC Z98270; XX SV Z98270.2 XX DT 08-AUG-1997 (Rel. 52, Created) DT 01-APR-2000 (Rel. 63, Last updated, Version 5) XX DE S.pombe chromosome II cosmid c1D7. XX KW byr2; cyclin-like protein; mitotic chromosome segregation; mlo3; KW protein kinase; snoRNA; Z15 small nucleolar RNA gene; Zinc finger. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-18000 RA Wood V., Rajandream M.A., Barrell B.G., Skelton J., Churcher C.M.; RT ; RL Submitted (05-AUG-1997) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA E-mail: RL barrell@sanger.ac.uk XX DR GOA; O14334; O14334. DR GOA; O14335; O14335. DR GOA; P28829; P28829. DR GOA; Q09330; Q09330. DR SPTREMBL; O14336; O14336. DR SWISS-PROT; O14334; PFD1_SCHPO. DR SWISS-PROT; O14335; SCR1_SCHPO. DR SWISS-PROT; P28829; BYR2_SCHPO. DR SWISS-PROT; Q09330; MLO3_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c1D7 is overlapped at the 5' end by cosmid SPBC2F12, CC EM:Z97211 and at the 3' end by cosmid SPBC11G11, EM:AL132717. XX FH Key Location/Qualifiers FH FT source 1..18000 FT /chromosome="II" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c1D7" FT /map="IIR" FT misc_feature complement(1..1565) FT /note="nominal overlap with cosmid SPBC2F12, EM:Z97211 FT S.pombe chromosome 2" FT CDS complement(477..2456) FT /db_xref="GOA:P28829" FT /db_xref="SWISS-PROT:P28829" FT /label=byr2 FT /note="SPBC1D7.05c, len:659" FT /gene="byr2" FT /gene="ste8" FT /gene="SPBC1D7.05c" FT /product="protein kinase byr2" FT /gene="SPBC2F12.01" FT /protein_id="CAB10981.1" FT /translation="MEYYTSKEVAEWLKSIGLEKYIEQFSQNNIEGRHLNHLTLPLLKD FT LGIENTAKGKQFLKQRDYLREFPRPCILRFIACNGQTRAVQSRGDYQKTLAIALKKFSL FT EDASKFIVCVSQSSRIKLITEEEFKQICFNSSSPERDRLIIVPKEKPCPSFEDLRRSWE FT IELAQPAALSSQSSLSPKLSSVLPTSTQKRSVRSNNAKPFESYQRPPSELINSRISDFF FT PDHQPKLLEKTISNSLRRNLSIRTSQGHNLGNFGQEILPRSSRRARPSELVCPLSSLRI FT SVAEDVNRLPRIDRGFDPPLTVSSTQRISRPPSLQKSITMVGVEPLYQSNGNEKSSKYN FT VFSESAHGNHQVLSFSPGSSPSFIEQPSPISPTSTTSEDTNTLEEDTDDQSIKWIRGAL FT IGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEH FT IVQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLVKNFIKQTLKGLEYLHSRG FT IVHRDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAPEVVK FT QTMHTEKTDIWSLGCLVIEMLTSKHPYPNCDQMQAIFRIGENILPEFPSNISSSAIDFL FT EKTFAIDCNLRPTASELLSHPFVS" FT misc_feature complement(483..1277) FT /note="Match to PF00069 pkinase, Eukaryotic protein kinase FT domain Score 342.58" FT misc_feature complement(867..905) FT /note="PS00108 Serine/Threonine protein kinases active-site FT signature" FT misc_feature complement(1188..1259) FT /note="PS00107 Protein kinases ATP-binding region signature FT " FT misc_feature complement(2262..2453) FT /note="Match to PF00536 SAM, SAM domain (Sterile alpha FT motif) Score 99.66" FT CDS complement(4273..4872) FT /db_xref="GOA:Q09330" FT /db_xref="SWISS-PROT:Q09330" FT /label=mlo3 FT /note="SPBC1D7.04c, len:199" FT /gene="mlo3" FT /gene="SPBC1D7.04c" FT /product="mlo3 protein" FT /protein_id="CAB10980.1" FT /translation="MSMELDQSLDAIIASKPKGGIRKRRARSNKPKPTKNAKPAVNTAS FT ALKSVISEESKIIVSNLPTDVTEAQVKELFVKSIGPCKRVSLAYGPNGRSKGIATIIFS FT RPGDATRAYEQYEGRLVDGTRKMKVEIILDPSRQLNSLAARVSPASNASATASKNGAKS FT SKRKTTRRRRTPNRPKKSAEELDKEMDDYFGSNEKE" FT misc_feature complement(4498..4704) FT /note="Match to PF00076 rrm, RNA recognition motif. (a.k.a. FT RRM, RBD, or RNP domain) Score 63.29" FT CDS complement(6201..7586) FT /db_xref="SPTREMBL:O14336" FT /label=SPBC1D7.03c FT /note="SPBC1D7.03c, len:461, SIMILARITY:Saccharomyces FT cerevisiae, CLG1_YEAST, cyclin-like protein clg1., (452 FT aa), fasta scores: opt: 235, E():4.9e-06, (28.9% identity FT in 280 aa)" FT /product="hypothetical protein" FT /gene="SPBC1D7.03c" FT /protein_id="CAB10979.1" FT /translation="MSFPYQHTSRSQVQPPLAAPGLSMFAPVSSSNSANSASSVAALLS FT HAPMYGLGQRRPSFLPGVSVPDTLSVRSGFSIPSSSHHPSAVPSLLSQHRLQQPQPRLY FT PSAPLNYYWPSYQSVPSAAPPPPSQQRYMPDSAVAYNPNQDQFGNSVNVSAACNNVSAP FT LIANNCAPSFYQSRHPVADVPVTNNTATTTSETDNTIPGNLNMPSVANVQQRISPVCKT FT NMEDQEETVYTGGVAAKLDYKMDQMVEYLSIMTCKLYARFLNNAQMHSLANSLPGLVFS FT FRKVVTQILTSTRLPRASCLLALSYLSDRLDAASQTTDFVNQWTKESLFFQICALLTTA FT LILANKFLDDNTFTNQSWSQVTGFRTALLNSFEQDWLASMSWNLSPGPRGQKAWEWWSA FT SYSLFTSSNATYSGEQKTYSPTTLSTNAPPSPSSGRSCSNCNYYYPYTPVGYYPVYNRY FT AMT" FT misc_feature complement(7587..13748) FT /note="low complexity gene free region, with high G-C/G+C FT in first in 4253-7500 and low G-C/G+C in 7500-10000" FT misc_feature 9694..9749 FT /note="possible misc RNA, short region of DNA highly FT conserved with c2D10" FT CDS 13749..15446 FT /db_xref="GOA:O14335" FT /db_xref="SWISS-PROT:O14335" FT /label=scr1 FT /note="SPBC1D7.02, len:565, SIMILARITY:Candida albicans, FT CAB41348, zinc finger protein., (574 aa), fasta scores: FT opt: 532, E():2.4e-19, (29.5% identity in 577 aa)" FT /gene="SPBC1D7.02" FT /gene="scr1" FT /product="glucose mediated repressor of inv1" FT /protein_id="CAB10978.1" FT /translation="MSEATTATTTGKPSRSTKNPDAPRPYKCPLCTKAFYRLEHQTRHI FT RTHTGEKPHVCTFPGCAKRFSRSDELTRHARIHTNANSRRNAAAAAAANNSARSSNSPA FT GNLEPSTNNAGVHMTNASMNPNVNPSYPVFIPQVGMSVAPPVATAAVSMSYPHHYSASV FT QQQQATFVSNGQPHNLPAQAQPATIYGIPDALHTTQNGTTIHVTGTPPGAVSQRSEPDS FT RLSSMNEMQLLASAAANQLDAAPRITPTKSSGVNLMPLSNAPSPPKQMNVVGSLPSSSN FT TSPNHLASVPNRGLTSNSSTGSFTKYTNGSSNSLYSNSSMQTPYLPSKSNSSTSLHSMY FT GVGTTAYAPQSLRYAHYNYLPYSRPSVSNGFDDDSSSSDFAHFRYQRRSRPVSPCSTAP FT SSPTFSTRSFSPTPDVTPLVTPAHSPRLRPMDDPSCVQLPSIRSLSLRPSQVPLIPPLK FT CDPNAFSASTPASGAVSRTPSSVSLSSLSNVNSSMPHKPASQSNVGPVRISSNRRSRKF FT SSSSRVSVSNLLAGSPPSPSSSTKSASSSYSTTTPAFSIGPLTPMTKP" FT misc_feature 13824..13892 FT /note="Match to PF00096 zf-C2H2, Zinc finger, C2H2 type FT Score 31.42" FT misc_feature 13830..13892 FT /note="PS00028 Zinc finger, C2H2 type, domain, C" FT misc_feature 13908..13982 FT /note="Match to PF00096 zf-C2H2, Zinc finger, C2H2 type FT Score 32.68" FT misc_feature 13914..13982 FT /note="PS00028 Zinc finger, C2H2 type" FT intron complement(16203..16425) FT /note="confirmed intron - probably from the 3' UTR of FT SPBC1D7.01c" FT snRNA complement(16282..16382) FT /note="SPO223844 Schizosaccharomyces pombe Z15 small FT nucleolar RNA gene" FT CDS join(complement(17248..17256),complement(16984..17150), FT complement(16670..16832)) FT /db_xref="GOA:O14334" FT /db_xref="SWISS-PROT:O14334" FT /label=SPBC1D7.01c FT /note="SPBC1D7.01c, len:112aa" FT /gene="SPBC1D7.01c" FT /product="hypothetical protein; similarity to prefoldin FT subunit 1" FT /protein_id="CAB10977.1" FT /translation="MQNLASQIQEKAVDSQQQLRTIMVQIAAKERALKISELAKKELED FT VGEDKAVYTSLGKMFMKSDLASVRTHLDAEMASLREDIEALQKKQTYHETTASNAEQHL FT QKIKESIS" FT misc_feature complement(16833..16850) FT /note="ctaactgtttatttacag, splice branch and acceptor" FT misc_feature complement(16978..16983) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(17151..17173) FT /note="ctaatgagctttgggcatattag, splice branch and acceptor" FT misc_feature complement(17242..17247) FT /note="gtacgt, splice donor sequence" FT misc_feature 17901..18000 FT /note="nominal overlap with cosmid SPBC11G11, EM:AL132717 FT S. pombe chromosome 2" FT misc_feature 17967..18000 FT /note="SPBC11G11.01- see full length protein in c11G11" XX SQ Sequence 18000 BP; 5871 A; 3459 C; 3267 G; 5403 T; 0 other; gtagacaatt tattttatat ctactatacc taatcttttc tcctcaagga gtgaacaaaa 60 aatccccttc tctacgacta atgcatacat acgtttttga gttttacttg tttaagtgat 120 agaattcccg tagatatgtg ttattatata tttatgttat cgttttcaca aagtaaataa 180 aaataaaaag ttttttcttg aaaaggaata atcaatggat attttttaaa caaactgaac 240 atgtaaaata gtattttttt agtaactaaa ctcataatgg tatttatcaa ggacattcac 300 aaaatcatta aaaacatgaa tattgtagaa aaatatagca acttaaatca tacggtttat 360 aggttaaata aattcattag ttctaaatgg cataaatgca atgataatga tgcaaaaaaa 420 cataaaaaag atagatcgta aaataatgtt tctgttttca tcataactta gccggcttat 480 gaaacgaacg ggtggctcaa caactctgat gctgtaggtc taagattaca atctatggca 540 aacgttttct caaggaaatc tatggccgat gaagaaatgt tagaagggaa ttccggcaga 600 atgttctccc caattctgaa aatggcctgc atttgatcac aattcggata agggtgctta 660 ctagtgagca tctcgattac caaacatccc aaagaccaaa tatctgtttt ctccgtatgc 720 atagtttgct tcaccacttc gggagccatc caaaaagaag agccttgaaa agaagggcga 780 gcaccacccg tcttcgtaga ggtactattt agttcaagtt tcttcgatat cccaaagtcc 840 gaaattttaa tcttcccttt attatcaacc aagatgttcg caccttttat atcacggtgt 900 acaatgccgc gtgaatgaag gtattctaag cctttaaggg tttgcttaat aaagttcttg 960 actagcgttt cctcaaagct tccatacatt gtaagcaatc cggcaaccga ccccccagga 1020 acatattcca aaaaaatgtt caagtggtcc gaatttaagt tagaaccgag atattggaca 1080 atatgctcat gagacaactc ctgtagaaga gcaatttcac ccgctaatgc atctaaaagt 1140 ttggcatggc ggtcttttga ttcagaaaca gaatctaaga tcacttgctt aacagccatc 1200 aactcaccac tagatgcatt cataccgaga taaacttgtc caaacgatcc tgaacctatt 1260 aacgcaccac gtatccattt gatagactga tcatcagtgt cctcttcaag tgtatttgtg 1320 tcctcacttg tagtggaagt tggagaaatt ggggatggtt gctcaataaa tgatggggat 1380 gaaccaggtg aaaaggaaag tacttgatgg ttgccatgcg cgctttctga aaaaacatta 1440 tacttcgacg atttttcatt tccgttggac tggtataaag gttccacacc aaccatggtt 1500 atggattttt gaagcgatgg tggtctagaa atacgctgag tagaagatac agtaagtgga 1560 ggatcaaatc ccctatcaat cctaggaagt cggttaacat cttcagcaac agaaatcctc 1620 agagaggaaa gaggacaaac caattcggaa gggcgagccc gccgagagct tcttggcaaa 1680 atttcttgac caaaattacc aagattgtgc ccttgagacg tacgtatgct aaggtttcta 1740 cgaagagagt ttgatattgt tttttccagt agctttggtt gatgatcggg gaaaaaatcg 1800 gaaattctag aattaataag ctcgctagga ggtcgctggt aggattcaaa tggtttcgca 1860 ttatttgagc ggacacttcg tttctgagtg ctcgtgggaa gaacagagga aagtttagga 1920 gaaagggagg actgtgatga taatgctgcc ggttgagcca attcaatctc ccaagaacgg 1980 cggaggtctt caaacgatgg acaaggcttt tcttttggca caataattaa cctgtcgcgt 2040 tccggtgaag atgaattaaa acaaatttgt ttaaattctt cttcagtaat cagcttaatt 2100 cgactactct gtgaaacgca tacaatgaat tttgaagcat cttcaaggct aaactttttc 2160 aaagcaatag cgagtgtttt ctggtaatct cctcgtgatt gaactgctcg agtttgcccg 2220 ttacaggcaa taaacctcag tatacatgga cgtggaaact ctcgtaaata gtctctttgt 2280 tttaaaaatt gtttgccttt ggcggtgttt tcaatgccta ggtctttcag taaaggcaag 2340 gttaaatgat ttaggtgtcg tccttcaatg ttattttgtg aaaattgttc gatatacttc 2400 tccaatccga tacttttcaa ccattctgct acctccttcg aggtataata ttccataaat 2460 gcaggaaagt ggttgtacaa cgtataactt ctaagttcaa agttggtagc atttacgttt 2520 aacctgcctc ccttagtctc gtgctctttg acgtaacaat ataactatac actttataac 2580 cgatattagt ttcactaaat ctcattacca aaatgaagct gccaaaaaat tcgtaaaggc 2640 tgcttgttta tataggtatt gcaattctca cccggcacag attcagatat ctattaaata 2700 acacttacgt acatatacga gttccacaag gagtctaaat atcgacgaga aattgtaatc 2760 agatattaaa atctaaaact ttcgtataaa ccatgtgtag caagtgaata ataatctttc 2820 tctttatctg caatacaaat gtcgttaacc accgttcaga tactactggt ttaaggtacg 2880 aacgtaaagt actgttttaa caatttcaat gtttcaatcg gtttcagagg acggcaagaa 2940 tcgcgcacta aaattagcaa cccgcaaatg cgcattctga aagcgatttt tggtttgtaa 3000 cacaatcacg acggatcgta cagatctttc aaaaaaatca aaattataag tgccaaaaat 3060 atatgtgtgg gacttcaatt taaattgttt gatgtgacaa tggttcgaac ataaaaccaa 3120 gcaatgttta ccaaaacaaa tttcgagata cggtcggcaa ttcaaccata acaataattt 3180 acaaataata ataaacgtcg gaagcaaaaa aaacgggaat ggaagtgact agggtttaaa 3240 agtttcaaaa gaatgcattg cgcgtaattc atcaatcagc gagtttaaaa tgcaatcgtg 3300 gaaaagttct ataaatgtgg tttacataca aaggaaggaa tgaagccagt tctgtcatgt 3360 acaatttgac aaagatgaaa tagagccatc gaacgcgatg attttacgaa tagaaattcc 3420 tcatccaaac aagccgtgcc acatatagta aaacaagact tggaataagt gtgacgtgaa 3480 ccaaaaacca tcatgaacat aataaacaca gtcaagttgg ggtatggaag ctttgacttt 3540 cagcaaacat gcaataataa accctgtcgg taagctcaac ccagtatagt ttagcaacat 3600 gatgatcaaa acagctgcct tgtacagtaa cttagattaa ataaagtaac agtagccgaa 3660 gctaccatta tccacctctt ttaaccactg tctacatagg ttttgctttt gtattaaaca 3720 agaagggagc gcttatcaac cataaaggat ttctgcacaa gagctgataa agttgcaaac 3780 ataacaggtg aacagatatg ctaataatga actcgactca aagcttagct tcttggtagc 3840 gtttaagctt gcatactaca aatcaacaga tatgtcaaaa gttagcaaaa gtcaaaacct 3900 ccaacccaac gttaaccacc gaaaaagaaa taagtaacca aattcgttcg atgtcaatga 3960 aacatatatg tctatcaaaa aagagatata aataaaaaat ttaatgaaat tctttgaaat 4020 aatggcataa tggcaatatg acccaataca caccatatat actaacaaga actggttcag 4080 ctcacttctc caaatccatt acgaaagacc caaaacacaa aaacaacttc aagaactgcc 4140 attcgaaaca gcattatatt gccaatatta tttaactgag ggagtatgtt gtataggtcg 4200 ttattaatac caagaagcat ttgacatctt caaaatatat gtatatatag tagaatcttc 4260 aaattattaa agttactcct tctcatttga tccaaaataa tcatccatct ccttgtcgag 4320 ctcttcggcg gattttttag gacgattagg agttctacgg cggcgtgtag tcttccgctt 4380 ggaagatttg gcgccattct tgctagcagt ggcgctagcg ttgctggcag gacttacacg 4440 tgcagccaaa gaattcaatt gacgactagg atcaaggatt atctcaacct tcatttttct 4500 agtgccatca accaaacgac cctcatactg ttcataagct cgagtggcat caccaggacg 4560 agaaaaaatg atagttgcaa tacctttcga acgaccgttg ggaccgtaag ccaaggaaac 4620 gcgtttgcaa ggtcctatgg atttcacaaa aagctcctta acttgagcct cggtaacgtc 4680 agtaggtaag ttagaaacaa taattttaga ttcctcagaa atgacggatt taagggcaga 4740 ggcagtgttc actgcgggtt tcgcgttctt tgttggcttt ggcttgttag agcgcgcacg 4800 acgctttcta atacctcctt taggctttga agcaattatg gcgtccaagg actgatctaa 4860 ttccatagac atttttatcg agttactgtt gggtagttag ttgttgttag gtggtaaagt 4920 ggcgggtggg gtttacaact gatcaggatc taggtaaggg tagtacacaa ggtgtcgata 4980 tttaaaatta ttattttgta gattcctaaa tatatttagc gatgttgaac gcttacttta 5040 aagtcttcag aaatttgaca aaaaaataat attacaaatt aaacttactt tacactttat 5100 tggcatcaga actaggatgg acgcgttcac ttataaaagt tgagagatta ttgataaaac 5160 agaatttatt gtttttttgg aaagcaattt ttgtaaccat aataccaaac gtttgatatg 5220 atgcctacac gattagatag atgcaaacgc ttcgccgctt cttggtagct taacaatgca 5280 gaatctagac agaagaataa cgattatgca atttttagaa acacggaaaa cattcaaaga 5340 caacataatt cagaattaaa aagcacgatt cagtgcaaca gaatcaagta taagagatta 5400 tataaatccg ttatctcact agtagacata cgacgaatgc gcaataaaac taggtaatca 5460 taacaaacag tttgggagtt ggaaaatcgc aataaaaaat tttatgctta atccttagaa 5520 aacagcaagc aaaggtttct catttaagta tcaaaaggag aaaaaataaa caaaataagg 5580 acaaaaacga tgcccgaagt aaaatctttg ctaatgaaac agaaaaataa actcaaagca 5640 tccatgggcc ttttcatcta ttcacaatgt atttcttgat gaagctagtt gtataagtag 5700 actactaatt tttgaaggcg aactttaaaa aggaaatccg cgatccctat agtagtagcg 5760 gatgtatata catcaagcag tattaacaaa tcagaattgc atcaaaagat attccaatag 5820 ataacaaagc cacacgagaa agcaaaataa aagtccaacg acaaaaataa aacagatact 5880 gataagaagt tggttccttt ttttcggtat actacttttc aatttttttt gggaaatttt 5940 ttttttctct gttaaaattt gaaaaaataa gaaagtagaa aagcaagatc aaacggcaaa 6000 ttaatttcaa gagagccgaa ttcatcacgg agatgattag agaatacaat atgacgggtt 6060 aaacaaaagt tcccgtcata caatatgaaa agagaaaaaa gttacaagaa taacaaaaac 6120 acgtaaagtg tttataagcg caaggaaacg aaaaacaaac cccgtcaagc aacaacaccc 6180 gcagaaagta agcacgatca ctaagtcatt gcatagcgat tgtacactgg ataatatccc 6240 acgggtgtat agggataata gtagttgcaa ttagagcaag aacgtccaga agagggcgat 6300 ggtggtgcgt tggtgctcaa cgtagtaggg ctataagttt tttgttcacc agagtatgta 6360 gcgtttgagg aagtaaacaa agaataagaa gcactccacc actcccatgc cttttgacca 6420 cgaggaccgg gactaagatt ccaggacatg ctagctagcc agtcttgttc aaagctgttc 6480 aacaaggcag tacggaaacc agtaacttgc gaccaggatt gattggtaaa cgtattgtca 6540 tccaaaaact tattagccaa aatcaaggcg gtcgttaaaa gagcacatat ttggaagaat 6600 aacgactcct tagtccactg gtttacaaaa tcagtcgttt gagatgcggc gtcaagacga 6660 tcggaaaggt atgacaaggc aagcaagcaa gaggcacgag gtaaacgcgt agacgtcaaa 6720 atttgtgtaa cgaccttacg gaaagaaaac acaagaccag gtaaagagtt agcaagagaa 6780 tgcatttgag cattattcag gaaacgagca tacaacttac aagtcatgat agacaagtat 6840 tccaccattt gatccatctt gtaatccagt ttagcagcaa cacctccggt ataaacggtt 6900 tcttcctgat cctccatgtt agttttgcag acaggagaaa tacgttgttg aacgttagca 6960 accgaaggca tgttaagatt acctgggatt gtattatcag tctcggaggt agtagtggcg 7020 gtattgttgg ttacaggcac atctgctacg ggatgtcgag actgataaaa ggaaggagca 7080 caattgttag caatcaaagg ggcggaaacg ttgttacatg cagctgatac attcaccgaa 7140 ttgccaaatt gatcttggtt aggattatag gcaacggcag agtcaggcat atagcgttgc 7200 tgggagggtg gtggaggtgc ggcagatgga accgactgat aagatggcca gtaatagttt 7260 agaggcgcag aagggtagag acgtggttga ggttgctgta aacggtgctg cgacagaagg 7320 gaaggaacag cggaaggatg atgagaggag gaagggatgg agaagcccga ccttaccgaa 7380 agcgtatcgg gcacagaaac gccaggtaag aaggacggac gacgctggcc aagaccatac 7440 ataggagcat gactcaacaa agcagcaacc gaagaagcag agtttgcact attgctggac 7500 gaaacaggag caaacatact caagccgggg gcagccaaag gaggctgaac ttgagaacgt 7560 gaagtgtgct gataaggaaa cgacattgct gaagaatttc gaaaaggaaa gcaaattgaa 7620 gaattaaaaa aaaaattttt aactcctttg ctattctacc taatcaagtc tttttcgagt 7680 tttgtaatcg atttcttgag tactcctttc aaggaaagaa gaatacaaag gaagaacgat 7740 aaaaaaaaat gaaaaagaga taaagaatgc tcaacaataa gaaatttacc caagagacag 7800 gaaaaagact tattaacact cacttctagc aaaacccgac caaggaatgc ttgtttcgct 7860 ggcaaataga cgaggcttag taaaaagctc gacttctgca aaaaaactgc taatatagaa 7920 ggaaaaaaat aggattgaac cctccaaact aaattttacg gtggttggtt gtgcgcaggt 7980 tctgaaaagc tggtaacgca gttgaaaatg cttgcaactt aggaaagaga attttttagg 8040 aataaaaaat ttcactttgt taagcactga aaaatagcgt agcgttgaag attattcagc 8100 aagaaagtta aacccaaatt aagatatcta acgtaataga tcggttagat aactttatgg 8160 attttaatta gcaattgccg gtgaggaaaa ttgggagcga ggtaaacaaa caatgggaca 8220 agcaggaaaa aaatcaaaga aaaataagtt aaacgtagca agacaaacaa taagtatgta 8280 aagaggagaa tttgaaagtt atctaaataa agaaacaact tgagaagtaa aaatcgagta 8340 gaaagtgaaa tgaaatggaa ggagcaatta aagaggagag aataaacaag aactgagtat 8400 gatagacgaa aagtagacgg aaaaaagaaa ttaaagagac aagagaaaat caactggtgg 8460 atgtctttgt cgtataagaa aagatgtata aatagaaatc aaagattaaa aagggaggta 8520 atgtttactt cagcaagttg agaaaaaaaa attcaacaat tagcttttcg agacaatttg 8580 gagtgaaacg aaaaaaaaag taaaaaataa cagtaaacaa caaaaactga aaaaaaaggg 8640 gagatgaaga gcgagtaaag aaatcgggtt tgtaattata aaaggataag tagggatgag 8700 cgattagatg aatgaaaaaa cagagagaga gagagagaga gaaaaagaaa aaaaaaagga 8760 ttaaaaagta aaagaaaaag aaaaacagac tacaaaatgt aagctgaaaa aaaaaaaaaa 8820 aaaaaaaaaa aagttgttca agtctcaaga cagtatacag tacgcaaact tttttgaata 8880 agggctaacc aaagcactga gtgaagagtg tattggcagt tgggggggaa gccgtagaaa 8940 gaaagcaagg cagatgcttt atatatatat atatatatat aactatatgt acttgagtaa 9000 ataaataaaa agatgcgcgc ataaatacaa ttgtagcagc gaaagaagaa aacgtaaaca 9060 aacaaaccaa tgaaaaatta ggaaaccaat gacagcatga atactcagga aaatgagaga 9120 gagaaaacga aattaaaaga ggagagtgaa ggcacagtaa aaggaaaggg aaacaaaata 9180 acaaagcaaa gccaaaacaa aaacaaacga tgctagaaaa gaagaaggcg cgaaatcaag 9240 ggcgcgcaaa agaacaatta agagtgtaga gaagaaaacg cgtgaaatta aaaaataaaa 9300 ggaagagagg aaatggggag gaaggaagga gaaaacgcaa gcaaagtttg ttgatgtata 9360 taggcaaaaa gccgtcggag ccagaatgag cattaacgga gcacatgaga gggagacaaa 9420 ccttgttgag tggagagtgg aaggagggaa atggaggaaa tcgttaaatg ggataatgaa 9480 agagagagag agagaataag aaaaaagagc gaggaagagt ggagtggttg aggggaatag 9540 tggggtgaaa ggaggaggaa ggaagaagga agggaatgca gggagtgatc gttaaagatt 9600 tggaagagag tggttgaatg aaacggtgaa tacgatagtg aaatagaagg agtcgatatg 9660 agactacgtg gattgtcttg tcttactagt tctaggtaaa catctgtagc aaaagattgg 9720 ttcctgctgt ttgaaaatca tttcatttat tggagaatac ggtggagaaa ggaagatcgc 9780 taataagaaa agggagagga aattatcata ggttatgttt gttttatttt acattgatct 9840 attgaaagaa ggaggtgcag agcgattctt gaaaaggtcg tttacggtac tatgttagaa 9900 attgttaatg aatctattgg aaaaagaaaa tcaccccaag cgctaacaag ttgaaaggag 9960 caggcaagag agagtgcaag gcaatagacg gatgcagagt tgtggcaaag gaggtgcgga 10020 aggagcagtg cggtgaggta gagaggtcga gaaagcgaca ctgttgtaat aggaagaaaa 10080 aggagtgtta gggatggcaa tggccgaaga agcaaaaaaa taaacaaaca agaaaaagaa 10140 aaagaaaaaa gacaaaaaga caaaaagagt aggcaataca catgaagaac aaatgataaa 10200 ataaaaacta gactacgaaa taaaaaataa atactgaact gtgaaataaa aactaaatta 10260 tgaaatgaaa aaataataaa ataataaaat caaaaaaaaa aaagaataat cataataaat 10320 gataaattaa attttttctt tttttttttc tttttctctt tttttttatt tttctcattt 10380 tctgtctcct tttttaattt cttcaacctg tcacatcatg aatattgctg ctgccttctt 10440 tgcagtcgaa tgaagaaatt aaaaaaattt ctttcccact aatgatgctc caattggggt 10500 ggtaaaggtt tgagggatga aagaaaaaaa caattttttt tttgctgccg atgtagcgac 10560 ggaggaatct gtcacagcaa cagcaacgat agtagtattc catcgtattt tatcccatac 10620 catcatcata tctcgtccat tgtagctagt aataacacaa tgatcctata tgatttgaat 10680 caatactgag tgtgctagat atacacttat actttttgct tcactcttaa attctcactt 10740 ctcttaaatg ttcacttctc ttaaattctc acttcactct tatactctca ctactgtagt 10800 ttttactact acagtattga ttactactac caaataaggg gtattttctt cctactgtag 10860 catagtctat tctactctac gcttcactgc actgcactgc aatgtattac acaagcaaaa 10920 tcatttaaca gtccatttct ctgtatacgc tacaatgcct tatgaatgtt taacatttga 10980 ccaagagact gtgtttcaca gcacttgggg ttcccccact tgacgccttg ggctaaacac 11040 tgggggggag agaaggaggg ggtttgcata gggaagagga aaagacggtt atgttattgc 11100 ttgattaagg aatttcttgt tttatggttt ccttagtaaa tgccgccatt cggtgacctc 11160 cacctttggt gtcgaggttg agttttctag ataaataaac aaggatgcta cgctcgtcat 11220 cgccgctcat atcgaccctt ttcaacaagt tctggcttgg acgagtttgt ccagtttagg 11280 gactctccgc agcttaataa atttgactcc cggaggaatc agaagatgac gttgacaaga 11340 aaaagcggac acattagggc taaaaaagcc aaatcgccaa aagtctcgaa tggggatgcg 11400 ttgcgatgcg ataaatgaga attacgagtc gcagtacaag cacggtcgag agagagagag 11460 agaaaaaatg cagtaggagg aaatagagag acgagataaa gcgacaatat aaaattcaaa 11520 taaaaagact tcgaaaatgg attcaagatt gtaaaatatg cacaatcatc aaaataatta 11580 cccaattcat ctttacaaga atattcaatt catctttaca ttatcactat aatcataacc 11640 acaactttaa ccatcaaaac aatacacacc aacaagaaaa attcactaaa ttctaccacc 11700 tatacatatt taaaaaacaa acaaacaaac aaataccaac accaacactt atatttcata 11760 tgctgttcac ctctggtatt cctcttgtct atacctcttc tcttcttctc ttctcctctt 11820 cttctcttct cctcttctcc tcttctctcg tctaactttg cttcaccttg ttttcttacc 11880 tctccccttc ctccttcctc ctccctctcc ttcgctatct tctccttacc ccacacctcc 11940 ccaccctctc tatccttcct ttaacccccc atcaccattg ccctcgttaa gttacttttt 12000 agacttctct cgttaacctt catcctttcg agcgctccgc ctttccacct cgcccatctc 12060 cttcccctcc taccagcaag cgccaccata tttctctatc gactgcgtta ttctgaatta 12120 caaagtggat cccttcctcg tgctcctttt acccctccct tttctccaat tttaccatat 12180 cgcaactgca ctcgaatacg taacagcata tatatatacg aaacgtaccg cccggagatc 12240 actcccctcc tcgagtattt agctaaccca caccccgcgt ttttcatttt taaccgcaca 12300 ccacaccacc atactcaaag taaatcaagc tccaccggta gtatccccat actaccagtg 12360 tgtgacaaag tgaaaatttt ttaatttcaa ggcttcaaga cttgtttgct tgctttcttc 12420 catttgactt gggttttcat agcatttcct tcagttctct gcgttgcctg ctactttggg 12480 atttccttag agtcgtaaat tttttttttt ctttcccaat tttttcaatt ttctcttttc 12540 attcttcctt ttattattat tttattttta gttttattct attttatatt tttctccctt 12600 tcctttcttt tccttcattc ttcttttttg tttgtgggtc tgtttttatt ctattttttc 12660 ctcttctact tcttctgtat tttccttaca tccaactttg gaaaatctca tccatccgtc 12720 ttacattgcc tcgactttgt atcgactgtt tttttctcac ctcatctgct ttgctttgct 12780 ttgcattttc ggatctcaat ccggttcctg ttgtattcgg tccgttaatt tttaaatttg 12840 tcgccttctc gctacatcat tcctctcttc gttcgatcga gggatccgtc ttttttcttt 12900 cgtcaacaaa ttgacttgtc tattcttcct cctctttctc cttttctttt ttgtccatcc 12960 attagtcctt ctgtgtgttc gtcttccatt gccactcaca taatcgtctt gttggatcct 13020 ttttcttgac tcccattcaa tcgccttttt tttatctctt cgtataactt gttgaaagtt 13080 tggctgcttt tttctttttc aagctttctt cctcttcgtc ctatacttta ctccgccttt 13140 agaagctttc ttcccatccg ccatatctat atctatttta tctattatta tatataggtg 13200 atcttgttat attgttttcc ttttcattgg ttccttcatt ggcattttct atcaatctct 13260 cttcttcgtt tacattgcct tcctcctcgt aaacattttc cttttttggc tctcatctgt 13320 ccaacaaagg atcctgctta ttcctctttt ttacttcaat tctttttatt attatttaca 13380 aagttatttt tttcccaagt tgttttcgta atctttggaa ctttcgtttg ggctcctttg 13440 aagcattcaa ctatataact ttgaatttta ttttttccaa tcctctctca tcgttgaaat 13500 ttcttctcgt tattaactag aattcctcta atcttctttt ttttctcttc cagcgatttt 13560 tttttattat cttcactatt actattatta ttattattat tattcatttt tttctttaaa 13620 cggtcgtttc tttctctttc ttgggtgaaa taagctattt tttattaaat actaccctta 13680 ctcgtgctat ttttttcttc tcttttttta cttctccttc tttgccgtgc tctgtttatt 13740 acttcgtcat gtccgaagcc accactgcca caacaaccgg taagccatcc cgctctacca 13800 agaatcctga cgctcctcgt ccttacaaat gcccactatg caccaaggcc ttctatcgtt 13860 tagagcatca aacccgtcat attcgaacgc atacgggtga aaagcctcat gtttgtactt 13920 ttcctgggtg tgccaaacga ttctctcgta gcgatgaatt gacgagacat gcacgcatcc 13980 atacaaatgc aaactctaga aggaacgctg ctgctgccgc tgccgctaat aattctgcta 14040 gaagctccaa ttctcctgct ggcaatttag aaccatctac aaacaatgct ggtgtgcata 14100 tgaccaatgc ttcaatgaat cctaatgtga atccttccta ccccgtgttc attcctcaag 14160 ttggcatgtc ggttgcacct cccgtcgcca ctgccgccgt ttccatgagt tatcctcacc 14220 attactcggc ttcagtgcaa caacaacaag ctactttcgt tagtaatgga cagcctcaca 14280 acctacccgc tcaagctcaa cctgccacta tctacggtat tcccgatgcc cttcatacca 14340 ctcaaaatgg tactacaatc catgttacgg gtacccctcc gggtgctgtt tctcaacgct 14400 cggaacccga ttccagattg tcgtccatga acgagatgca attgttggct tcagcggctg 14460 ctaatcaatt ggatgctgcc cctagaatca ctcctacaaa gtcttcgggt gttaatttaa 14520 tgcctttatc taatgctcct tccccaccga agcagatgaa tgtagtaggt agtctgccat 14580 catcatccaa tacttctcct aatcatctcg catcggttcc caatagaggc ttaacttcta 14640 actcatccac tggttcattt acaaagtata ctaatggctc gagcaactct ttatatagta 14700 attcgtctat gcagactccc tatctgccta gcaaatctaa cagtagtact agccttcatt 14760 caatgtatgg cgttggtact acggcttacg ctcctcagtc tttacgttat gcccattaca 14820 actatttgcc ttattctcga cccagcgtat ccaatggctt tgatgatgat tcttcgtcaa 14880 gtgattttgc ccatttccga taccagcgtc gctctcgccc ggtttccccc tgcagcactg 14940 caccgagtag tcctaccttt tccactagga gctttagtcc caccccagac gtcacacctc 15000 tcgttacacc ggcacattct cctcgtttga gacccatgga tgatccatct tgcgttcaat 15060 taccttctat ccgctcgctt tctctacgac cttctcaagt tccgttaatt cctcctttga 15120 agtgtgatcc taacgccttt tccgcgtcta caccagcctc tggtgctgtc tctcgtactc 15180 catcgtccgt ctctctgagc tcgctctcca acgttaatag cagcatgcct cacaaacctg 15240 catcccagtc gaatgttggt ccagtccgta tatcatcgaa tcgacgatca cgcaagttct 15300 cctcttcttc gcgtgtgagt gtcagcaacc ttttggccgg atcaccgcca tctccttctt 15360 catccacaaa gtcggcgtcg tcttcctatt ccaccaccac accggcattt tcaatagggc 15420 cgttaactcc tatgaccaag ccctaaccca atatttgcgc tgtgaacgct agttaccttt 15480 gcttccttta aaccatctaa acaccttggt tgtgtgttat gctattttat aaattaagta 15540 ttaaattttt tattagtatc atgagtctcg acatttgagg ttccattgtt cagtttttct 15600 tttttttttt gttttaaatt ttttttaaac ttcttggcat ataattagta atgttatttt 15660 gtgtttatta gactgctttc ataggtgaaa atttatgtta tatgtttaaa ttacttcttg 15720 atcagtgtat gggtacaata gaccataaac taataaagtt attttttttt accgatggtg 15780 tttaatcctt tttgctttta tttagctaaa tttattgtat ataaagttgt ctgcagatct 15840 tatcaaaaag ttgaactgca ggatctacat taatgacttt aactagaact acagcaaatt 15900 accatcataa tttaacggca acttcacaat tcgtatatag aattattatt ttaattcaga 15960 aacaaacatc tgatatgaga gaccttcaag tcctaatatt gtcgccatag ttaatattaa 16020 tacattacta catactttgt taaacaatga ttagtgacag ttcgtttcgg ataattttat 16080 tcataaacta taagtaagct ataaactatt ccttgtgcat ctctcaaaaa gaaatcagaa 16140 gttaatggag aacaaaacag cttccacaca gttaatgata tccttgaaaa aatatagaac 16200 accttaaagt atgggtcagt aaaacagcca acacaaaagt cagacaaaca gacgttgaaa 16260 aagaaagaaa caaaagggaa cgagaaatct cagactgacg tgcaaatcag atggaaaaag 16320 tttcagcata cgatgctcag ttgaactatg cttttttgga atcatcaaag aaatcctttc 16380 tccatttact tttccaaacg tcaattctaa cagtagaaaa cttaccttaa aagtataaca 16440 tatactaaat tcacaagtct tcaagcttga aatttaagta tccatacaca aaagcgcagt 16500 cacagtgatc aaaatttcgg ctcacaaatg ccccagtatt tgttagaaat gcaagaagat 16560 taatggaaca aatttacttt aattctacag ttttaaagat aaaaaagaaa gtcataaact 16620 ttccaatccc ataatccaat ttaccaatga gatgattata attgatgttt taagaaatcg 16680 actcttttat cttttgtaaa tgctgctcag catttgaggc cgttgtttcg tgatatgttt 16740 gtttcttttg tagtgcttca atatcttctc ttaaacttgc catttctgcg tccaaatgtg 16800 tacgtacgga agccaaatcg gatttcataa acctgtaaat aaacagttag taaatgactt 16860 tacatataga ttgacagtac ggtcaattcc attccaaaag tgctgttttt gctaattccg 16920 tattctttcc ctatttttat agaaaagaaa ataaaaatac atgtttcatt ttatgacact 16980 tacatctttc caagagaagt atatacggcc ttatcttctc caacatcctc taactctttt 17040 ttggctaatt cacttatttt tagtgcccgt tccttggcag caatctgtac cattatggtc 17100 ctcagttgtt gctgtgaatc aaccgctttc tcttgtattt gactagctaa ctaatatgcc 17160 caaagctcat tagtttacca tgtaacacag ttaaaaagag ggaaattcct aacaaaataa 17220 ttctcttctc aatgatgaaa tacgtacatt ttgcattatt taaaggaaac ttgggtatat 17280 ctcaagaact tatttttttt ggattgaatt gctctttcca aaattatggt acaaagaata 17340 gtccttttaa tacttttttt atagacaaat caagaacttt ttcaatatat ttgaatatac 17400 cacctttaca agtatatcaa gtcttaggca aaatgttggt taggccttaa gtacaaagct 17460 ggcatgttac aagctacttt acactgcttt tattatcggt acgtttcgca aatgtgaatt 17520 acataatacg ccacaatttg taataaatat tttgtgaaat gttttgccat atccttaagt 17580 tcttccttac ataaattgtt ggcgatggcg ttcacaaacg aatcttcatt tcattccttc 17640 tctgtttcaa atttttgtgg aaaaagcata tccatattct tactaaatcg gatttctgga 17700 cttttctatt gctttggaaa tccattatcc ttgtagttca ctcatttgcg cctcaaatcc 17760 tttataattg gaattggctg tttacattga taatttagca tttttgcatc atactcaacc 17820 ctttttttct tcttttatat ttgagttgtt gaattttttt tcaagtgact gtagtttttt 17880 caacattttc cgtttattta tattaatccg cctttaaaat aattaaggca cattcaaaga 17940 ccaatatagg aagcaataac gacatcatga ctgaaaaaca cacccttcgc ctcgctgatc 18000 //