ID SPBC19F5 standard; DNA; FUN; 14000 BP. XX AC AL022599; XX SV AL022599.1 XX DT 22-APR-1998 (Rel. 55, Created) DT 23-NOV-1999 (Rel. 61, Last updated, Version 3) XX DE S.pombe chromosome II cosmid c19F5. XX KW aspartate kinase; Beta-transducin; cyclin; G-protein; puc1; KW Trp-Asp repeats; WD repeats. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-14000 RA Lyne M., Wood V., Rajandream M.A., Barrell B.G., Bothe G., Pohl T; RT ; RL Submitted (21-APR-1998) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk and GATC GmbH, Fritz-Arnold-Str 23, D-78467 Konstanz, RL Germany. XX DR GOA; O60163; O60163. DR GOA; O60164; O60164. DR GOA; P25009; P25009. DR SPTREMBL; O60161; O60161. DR SPTREMBL; O60162; O60162. DR SWISS-PROT; O60163; AK_SCHPO. DR SWISS-PROT; O60164; PESC_SCHPO. DR SWISS-PROT; P25009; CG1P_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 80% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c19F5 is overlapped by cosmids 25D12 and 13G1 at the 3' end. XX FH Key Location/Qualifiers FH FT source 1..14000 FT /chromosome="II" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c19F5" FT /map="IIR" FT CDS complement(1..830) FT /db_xref="GOA:P25009" FT /db_xref="SWISS-PROT:P25009" FT /label=puc1 FT /note="SPBC19F5.01c" FT /partial FT /gene="puc1" FT /product="cyclin" FT /gene="SPBC19F5.01c" FT /gene="SPBP8B7.32c" FT /protein_id="CAA18649.1" FT /translation="MLVSSNEEQLTAHTPTSSSSIEPKILAACSYSLSVGPCSLAVSPK FT GVNSKSPSLKNETAFVVDSVSTLSAESSALLYNTQSSLLTGLSMNGYLGEYQEDIIHHL FT ITREKNFLLNVHLSNQQPELRWSMRPALVNFIVEIHNGFDLSIDTLPLSISLMDSYVSR FT RVVYCKHIQLVACVCLWIASKFHETEDRVPLLQELKLACKNIYAEDLFIRMERHILDTL FT DWDISIPTPASYIPVLDPIFFLVLDASMFVPNLFKFPASKIACSVMNIVNEHVGS" FT misc_feature 1..3706 FT /note="nominal overlap with plasmid SPBP8B7, EM:AL032684 S. FT pombe chromosome 2" FT misc_feature complement(9..593) FT /note="Match to PF00134 cyclin, Cyclin Score 240.19" FT CDS complement(3920..6052) FT /db_xref="SPTREMBL:O60161" FT /label=SPBC19F5.02c FT /note="SPBC19F5.02c, len:710, SIMILARITY:Saccharomyces FT cerevisiae, Q06679, similar to g-protein beta subunits., FT (776 aa), fasta scores: opt: 1222, E():0, (37.2% identity FT in 740 aa)" FT /gene="SPBC19F5.02c" FT /product="WD repeat protein" FT /protein_id="CAA18650.1" FT /translation="MDIHRCRFIDYTPSAITAMAFSHKSGQNDSMPNNLLLAVGRASGN FT IEIWNPRNDWCLKTVLYGGVDRSIEGIVWSTGEEELRLFSIGFSTTITEWNLHTGKPLV FT NQDSNAGAIWSIAICDETKTLAVGCDDGSCVLFDISGGPGVIEFKRVLMRQTSRILSLD FT FQTKDHLVGGCADGVIKVWDLSTPNSAIISRMQVDRARKGEAALIWAVKSLRDGTIVSA FT DSSGAVKFWNGKFFTLSQSFKLHLADALCLGVSANGDMVFSSGIDRKTIQYSREGGKRE FT WVSNSFRRFHSHDVRCMAVFECKSLDVLISGGMDMMLAVIPVRQFNRKNHRMISAVPQR FT PRMAVAPKARLFMLWNDHEVLLWRIGSPGYRFLLKIVLADEENISHAAISPDGELIAIS FT SVLRTKLYQLQYSDENVKVETVEDSFLSNIGASLLSFTVDKNKLILVSNDSEIFLIELS FT RLDSRQLEVFELSQPTSKKIAPRQRSNVSSMCDGICSIAVSSDGDYFAVADTVGNIFCY FT SLSNLTYSELPRVNTYVRAMAFRPDVRGRLAVATAGNQVYEFDVQSRKLSEWSKNNSTN FT MPKEFSQLLDKAFGAFFDSKHPSRFWIWSANWVSFFDLNLQLPAPRAAGKRKIEMNATV FT DGNLNDKKLANANSNGISNYGTGDSRCFWITHKYRPMLLVGSVGNSELLVVERPIADML FT MSKSMPASFYEHKFGS" FT misc_feature complement(5501..5545) FT /note="PS00678 Beta-transducin family Trp-Asp repeats signa FT ture" FT CDS 6910..8706 FT /db_xref="SPTREMBL:O60162" FT /label=SPBC19F5.03 FT /note="SPBC19F5.03, len:598, SIMILARITY:Saccharomyces FT cerevisiae, RSD1_YEAST, recessive suppressor of secretory FT defect., (623 aa), fasta scores: opt: 1528, E():0, (43.6% FT identity in 564 aa)" FT /gene="SPBC19F5.03" FT /product="possibly involved in secretion-by similarity" FT /protein_id="CAA18651.1" FT /translation="MVQFEANEKQFKLRREDCCLTIDRESGAVSFEPDELKPVARSKEN FT SVTLFGSIKLKKDKYLILATEKSSAAQILGHKIYRVHKFEVIPYRNLLADDQDELDLYN FT LLQNHLKTGPFYFSYTWDLTNSLQRSCTDEGKASPILRSDKRFFWNEFASKDFIDLIGA FT HSEVSLFITPMIYGFITSASTIVKGRTITLALISRRSKQRAGTRYFTRGLDENGNPANF FT NETEQITIVSDEKSEVTYSHVQTRGSVPAFWAEVNNLRYKPLMVANSASMAAAAAKKHF FT DEQISIYGDQVVVNLVNCKGHELPIKQLYENVIRRLDNPHIHYHYFDFHKECSHMRWDR FT VSLLLNEIQPELEEQGYTTLDTQKYRVLSRQNGVVRSNCMDCLDRTNVVQSCIGRWVLT FT NQLRKCGIIGATHPLRSVIPLDNIFCNIWSDNADYISLSYSGTGALKTDFTRTGIRTRK FT GAFNDFVNSAKRYILNNFYDGARQDAYDLVLGQFRPDVNFRYRLDLRPLTIRCVPYILL FT ACLILFFMTLFSRSSSTILPPSILLILTFLGIVASLYYCFAHGLQFINWPRLLLPSFLR FT SDMTPEGRVFVINRQLASKHKV" FT CDS join(9450..9562,9934..11380) FT /db_xref="GOA:O60163" FT /db_xref="SWISS-PROT:O60163" FT /label=SPBC19F5.04 FT /note="SPBC19F5.04, len:519, SIMILARITY:Saccharomyces FT cerevisiae, AK_YEAST, aspartokinase, (527 aa), fasta FT scores: opt: 1739, E():0, (56.3% identity in 494 aa)" FT /gene="SPBC19F5.04" FT /product="aspartate kinase" FT /protein_id="CAA18652.1" FT /translation="MSIAKNIENDPSKGWVVQKFGGTSVGKFPIKIAVDVAKEYLSTKR FT VALVCSARSTDTKAEGTTTRLIRATEAALRPAVGSVHDLVRIIETDHVQAARDFIQDVG FT IQDELIDAFHADCVELEQYLNAIRVLSEVSPRTRDLVIGMGERLSCRFMAAVLKDQGID FT SEFIDMSHIIDEQREWRNLDASFYAYLASQLASKVTAVGNKVPVVTGFFGMVPGGLLSQ FT IGRGYTDFCAALLAVGLNADELQIWKEVDGIFTADPRKVPTARLLPLITPEEAAELTYY FT GSEVIHPFTMSQVVHARIPIRIKNVGNPRGKGTVIFPDTISRHGSATPPHPPKIMPDDI FT SASLANKGATAVTIKDTIMVINIQSNRKISAHGFLASIFAILDKYKLAVDLITTSEVHV FT SMALYEESDDGNMHEAFVELRRLGTLDILHGLAILSLVGKHMRNTTGYAGRMFCKLAEA FT QINIEMISQGASEINISCVIDEKMAVKALNVIHKELLEPLALHEVPSQASMLVEKPWLY FT SA" FT misc_feature 9498..9524 FT /note="PS00324 Aspartokinase signature" FT misc_feature 9563..9568 FT /note="gtgagt, splice donor sequence" FT misc_feature 9917..9933 FT /note="ctaaataatttatttag, splice branch and acceptor" FT misc_feature 10241..10918 FT /note="Match to PF00696 aakinase, Aspartate kinases, FT Glutamate kinases and Gamma glutamate phospho-reductases FT Score 103.77" FT CDS join(complement(13776..13797),complement(13570..13737), FT complement(11782..13415)) FT /db_xref="GOA:O60164" FT /db_xref="SWISS-PROT:O60164" FT /label=SPBC19F5.05c FT /note="SPBC19F5.05c, len:607, SIMILARITY:Saccharomyces FT cerevisiae, YG2S_YEAST, hypothetical 69.9 kd protein , (605 FT aa), fasta scores: opt: 1508, E():0, (46.4% identity in 614 FT aa)" FT /gene="SPBC19F5.05c" FT /product="hypothetical protein" FT /gene="SPBC25D12.01c" FT /protein_id="CAA18653.1" FT /translation="MARVKQKGKAGAARIYITRNQALKKLQLTLADFRRICILKGVYPR FT EPKNKKKANKGSTAPVTFYYTKDIQYLLHEPIVQKFREYKVFARKLSKALGKGELETAK FT RLEARKPTYSLDHIIKERYPTFHDALKDIDDALSMLFLFSTMPVTDKIGAATVANCERL FT CAEFQHYVIRSNSLRKAFLSIKGIYYQAEIFGEQITWIVPYKFAQSVPTDVDFRIMHTF FT LEFYQALMGFVNFKLYNTLGLRYPPKIDVAKSESAAGLAAYELEESSSLPAIVHGNNKN FT ARKNIATLKSKIRDIVNSDANVVEQSEKTTEDADEEPETEENLDEFKPADGADNEDSKS FT LVSHISSSNTSLFSNFTFFLSREVPRFSLEFVIRAFGGKVGWDPILGSGSPFSESDPVI FT THHICDRPHISQKYEGRIYIQPQWVYDSINKGILERTDLYACGATLPPHLSPFVKVGEN FT DYDPEAELSAEENDDVSEALDDNISGEAVPISKKNDEPENVEQIDDAEEEDLEHQRELE FT AEAGGVAYSEYVKQNSKSAKKTKKRQRDTLTAEEKEEKEAKELSKMMMSNKQRKLYSKL FT KNENSKNENYNNALRNRKRDIEKRKKLKVEN" FT misc_feature 12222..14000 FT /note="nominal overlap with cosmid SPBC25D12, EM:AL031158 FT S.pombe chromosome 2" FT misc_feature complement(12283..12555) FT /note="Match to PF00533 BRCT, BRCA1 C Terminus (BRCT) FT domain Score 29.92" FT misc_feature complement(13416..13431) FT /note="ctaataaatataatag, splice branch and acceptor" FT misc_feature complement(13564..13569) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(13738..13751) FT /note="ctaattgaaaacag, splice branch and acceptor" FT misc_feature complement(13770..13775) FT /note="gtatgt, splice donor sequence" XX SQ Sequence 14000 BP; 4563 A; 2538 C; 2512 G; 4387 T; 0 other; gatccgacat gttcgtttac gatgttcata actgaacatg cgattttgga agcgggaaat 60 ttgaataaat taggtacaaa cattgatgca tcaagtacta agaaaaaaat cgggtctaaa 120 acaggaatat acgaagctgg tgtagggatt gagatatccc aatcaagagt atcaagtatg 180 tggcgttcca tacgaataaa taaatcctca gcatagatgt ttttacaagc taacttcagt 240 tcttgcaata atggaacacg gtcttctgtt tcatgaaatt tactggcaat ccaaagacaa 300 acacatgcta ctaactgaat gtgtttgcag tataccactc tcctcgagac atatgaatcc 360 atgagggaaa tactaagcgg aagagtatca atagacaagt cgaatccatt atgtatttct 420 acaataaaat taacgagtgc aggtcgcatt gaccatctga gttccggttg ctgattagaa 480 agatggacat tcagcaaaaa atttttctct ctagtaatca gatgatggat aatgtcttcc 540 tggtactcac ctaaataccc gttcattgat aaaccagtga gtaaagagga ttgagtgtta 600 taaagtaagg cgctagattc cgctgacaat gtgctaacag agtcgacaac aaatgcagtc 660 tcatttttaa gagagggaga tttggaatta acgccttttg gtgaaacagc taaagagcaa 720 gggcccactg atagagaata tgaacaggca gctaatattt taggttctat acttgaagat 780 gaagtgggag tatgagcagt aagttgttcc tcattggaag aaactaacat actgggtaga 840 caggtatttg aaaataatga gaaggaaaga gtagaaaagc tcttcacagt cgatgaagtt 900 gcagctcaaa gttcagtgaa ttattaaaaa aatgatactg aagaaaaaat aattggacat 960 aaacaggctc agattgcttg ttaagaggta gtggtcaaag cgaatagtgt ttaactaact 1020 gaaagcgata caacggcgga aaattaaggg acgatttaaa aaggaagaaa aaaaaagagt 1080 gaggtgacga ttaaaaaaaa gggaaaaatt actgggtttt caaggacgct aaagagatat 1140 caataatgga aggggtaata taaaggaatc gaaagagtaa attgcaaagg acttgtaaaa 1200 agccaagacg aaagaaccca ataatatata gtgaaaaaag gctatataaa tattaaaaga 1260 atgcaaaatg aagcggaaga aattagatgc gataaatata tgtttccaaa aaggttcggt 1320 gaatagttat ttagtttgat taacggattt cagaagcaga caatgcattc atactaatga 1380 aaatattaca aagaaacaca aggttaattc caaaaagaaa aaaaaaataa aaaaaaataa 1440 aaggaagaga aagatattta gtaaaatatg tccatatgca gcaaaaataa ggaaataaat 1500 ttcaattaaa ccaaacgatg tattgcaaaa gaaaaacaaa atttggttac gctgttcaaa 1560 ctttcgaatt catttacagt gcagtcaatt taatttaccg caaccttgat aggacagaaa 1620 ttataaaaga acaccaaaag ctggagaaaa gtaagtggta cagactcttt taaagaaaac 1680 aattcagttc cgtcagctac tattttataa aaaatgataa acggatacga ctaagagatc 1740 gaatttgtga acgattcgta ccaagcaata aataaagttg tcgcttgtat accaaaagca 1800 attatggtgt ggtaagaaaa gagaatgtaa caaaaaacaa ggcggaactg gtaaagagat 1860 aaattatgga aggttataaa cggtgggcaa tcgatatctt tataaggata aatcttatag 1920 tgtagtgaca atatcgcgaa tcggtatcct tacattgtga atgtacaatg tccattctaa 1980 ctcgtaattt ctgcaacgta actagctact gttagtaaca acaaccggaa ttttcggatt 2040 tgaattaatt aagcctcaag tgatctccat cttggtatgg ccgattcaca aatttaccat 2100 accaacgatg tgtactgaaa gcgtaaagta ctaacacaca attaattcaa tgggtcaagc 2160 acatcatgta agtgacgacg tagcccaaaa ctattccatt catagcacgc catctatcaa 2220 agaacttgaa caaagaaact agtacaaaat tttgattttc aaaagcggtt aattgataag 2280 ttacttgctg taaatcatat tggccaaatc gtgaaatgta cgtactgcta acattgcgca 2340 cgcaagtaag aaaaagtggg gacaagaagc agaggtaaat caattattca agaatgtaaa 2400 tattgacccg ttcgatcatc tacagctttt tttttatgaa aatcacgtta ttaacaaaat 2460 ggctggtgca atccagctat aactacagct agatagatta acattaataa tatcgatttt 2520 cttcacaata gcatataccg caatctttat tttacatagc agaaggaaat aagcagccca 2580 attactgtgt gtaaatgttt atcacttagt atatggatta aacaaattgt aaataatagt 2640 caagacttaa gtcagttaat ttccgatgaa ataattaatt tttgaggaga atgtggggaa 2700 tgaacatgaa taactagcat ggataaatag attcgcaatc agtgacataa cgatatttat 2760 gagccgtcta gtttcacaga taattccacc tggtggtgcg gataaaagta ggatagaaaa 2820 taacagaacc aaaacgttga aaaacgcatt gcttggctta aaggtcataa cattattcta 2880 ttcaatggaa aaaaatgttt ggtagttgaa cgagattgct tctcaacgca atgttttatt 2940 ttcactacga aatgttctca tgcttctaat ctatgacttc tactttacat gctgttgatt 3000 caggtggtgt ttttgtacca aagtgggggg tctaagtcgt tagtactatt gtccttcttc 3060 tggttagtac tgacagtttg tattacattt taagtgggat cgtagtaact aaatgggggt 3120 acataaaact ggtactacta aacagattta tctaagttgt gaacaaattt caataaacaa 3180 acgaatgtat aatctcatcg gcaagaaaat aattttttac gtcaatcact tatttcactt 3240 ctttatttta ttttgaatat atcaaatgta atcaagttta gaaacgtaga cgggttcatg 3300 tatgagcttt cttcgtttca tttgcatata tatcctttgt aagattctgt tactttgaat 3360 atgttttctt tataagttgt agatggtaat tgctactctt taaatacaag ctgtcttcta 3420 caataatttt aattttacca gagtattttt aattatcctc atgcgagtaa ttttctaatt 3480 atgtggtgta acaaaaatag cgttcggtta aattttagtt cgccgtgtta agtctattaa 3540 tcaaaaaatt tgggttcgta aaattgtacg cctatctgcc tagaatcaag tgaaaccata 3600 ttacaggcat aatgctccaa tcgataatgg gaataaacaa ctcagacttt ggaaattcac 3660 agctacattg ccataatcat attgtggatg ggtgtgtcac cttgaaatgt tttattgata 3720 aactaactag caactaatct atgcttttta tcggaaaaaa taaaaataaa ataaactcct 3780 ataataaaag acctttttgt acaaaatcat aataatacca ccctattcca gacatttttt 3840 ttacgtaaaa tgacatatta aaacctcttc gtttttttta gtacgaagaa actcctccat 3900 cttcatacat aatacatatt tacgagccaa atttgtgctc ataaaagctt gctggcattg 3960 atttactcat caacatatcg gcgattggtc gttcgactac cagcaattca gagtttccta 4020 cagagcctac aagtagcatt ggtcgatatt tgtgagtaat ccagaaacac ctagaatccc 4080 ctgttccata atttgaaatg ccgttcgaat tagcattcgc caattttttg tcattcagat 4140 tcccgtcaac tgttgcattc atttcaattt tacgttttcc ggcagcgcga ggcgctggta 4200 attgaagatt aagatcgaaa aatgaaaccc agttggctga ccaaatccag aatcgactcg 4260 gatgtttaga gtcgaaaaat gctccgaatg ccttatctag aagttgcgaa aattctttgg 4320 gcatatttgt agaattgttt tttgaccatt cagataattt acgggattga acatcaaact 4380 cataaacttg atttcccgcc gtagcaacag ctaaacggcc tcgtacatct ggacgaaaag 4440 ccattgcacg aacataagtg ttaactcgtg gtaactctga atatgttaaa tttgacaagg 4500 agtagcagaa aatatttcca actgtgtccg caacagcaaa ataatctcca tccgaagata 4560 ccgctatact gcaaatacca tcacacatgc tgcttacatt gcttcgctga cgaggagcaa 4620 ttttcttgct agtgggttgt gataactcga aaacttctag ctgacgagaa tccagtcgac 4680 ttaattcaat gagaaatatc tcggaatcgt tactaacaag gataagcttg ttcttatcta 4740 cagtaaaact aagcaggcta gcaccaatat ttgaaaggaa ggagtcctca actgtttcaa 4800 ctttcacatt ttcatcgcta tactgtaatt gataaagctt cgtcctcaaa acggaagaaa 4860 ttgcaattaa ttccccatca ggagaaattg ctgcatgtga aatattttct tcgtcagcca 4920 acacaatttt taataaaaac ctatagccag gagacccaat tctccagaga agtacttcat 4980 gatcattcca taacataaaa agccttgctt tcggtgcgac cgccatgcga gggcgttgag 5040 gaacggcaga tatcatcctg tgattcttgc gattaaattg tcgaacagga attaccgcaa 5100 gcatcatatc cataccaccg ctaataagaa catccaaact tttacattca aaaacggcca 5160 tacatcgaac atcatgagaa tggaaccttc taaaactgtt gctgacccat tctcttttac 5220 ctccttcgcg tgagtactga atagttttcc tgtcaatccc tgaagaaaat accatatctc 5280 cgttagcaga aacacccaaa cacaaagcat cagccaaatg tagtttgaac gattggctta 5340 atgtaaagaa ttttccattc caaaatttaa cagcacctga tgaatcggca cttacgatag 5400 tgccatcccg taaacttttc acggcccaaa ttaaagcagc ttctcctttt cgagcacgat 5460 ctacttgcat tctagaaatt atagcggaat ttggagtgct aagatcccaa actttgataa 5520 caccgtcagc gcaaccacca acaagatgat cttttgtttg aaagtcgagc gaaaggatac 5580 gagacgtttg gcgcatcaaa actcgtttaa attcgatgac acctgggcca ccactaatgt 5640 caaatagaac gcaacttcca tcatcacatc caacagctag agttttagtt tcatcgcata 5700 tagcgattga ccaaatagct cctgcattag agtcttggtt taccaatggt tttccagtat 5760 gtaaattcca ttcagtaata gtagttgaaa atcctatact gaataatcgt agctcctctt 5820 caccggtact ccaaacaatc ccttcaatac tgcgatctac accaccgtat aacacagttt 5880 ttaagcacca atcgtttcga gggttccata tttcaatgtt tccgctagca cgtccaacag 5940 cgagtagtaa attgttaggc atagaatcat tctgaccgct tttatgggaa aatgccattg 6000 cagtaatagc tgaaggggta tagtcgataa agcgacaacg atgaatatcc atgttgctaa 6060 ttaaatttaa ataaaagaaa gaacgaacag gaaactaatc agaagtatgt atggaaaaaa 6120 ttattttttt gcaccaaagt caatttccca aatcaaaccc aaaatatcgc caaagtcggc 6180 tattagctag ataattgtaa tccttttttt gaaaaaaata taaaagaaaa aatttaaaag 6240 gtttcaatgg aataaatcaa ctatgttttc gctctttttt tcaaaaatga aaattttgat 6300 gaacgagtga atcctcagga ttcaaccaca aaacgaagat cacagtagta tagtgatttc 6360 aacgtgaaga ataatcaaag tatctactat taatattaca aatatgtatt attcttctaa 6420 agcactcttc agagtgtcct ttggaactcc gttggtaaat ggtagtggaa gaaatttgta 6480 tttacaaggc tagcacaaca tgaccaagag catctaccat atttaggtga aagtgcgtta 6540 gcagttatgt gtacggcaat taagttttga aagtattcat gttaattatt ttacatttta 6600 agatgtcaat gagatattta ttctcaatat ttaaacaaac accagatacc ctaggaataa 6660 ttcagcgacc ttcaatatga tcattgtagt ataatatttt attgaggatg gatacttact 6720 agcaaattta gtaattgata aatcatagtg aaaatgtcat ttattctatc tacgataata 6780 ccacatgact tagcatagaa aaccgtatgt tacagtacag cagtaagcag gttcgttgtc 6840 tgccgtctac caaccatcaa cttcacagat cttggtatct atcctacaaa aactttagaa 6900 aatttcttca tggttcagtt tgaagcaaac gagaagcaat ttaagcttcg tcgagaagat 6960 tgttgtttaa caattgaccg agaaagtggt gcagttagtt ttgagccgga cgagttgaaa 7020 ccagttgccc gcagcaaaga aaatagtgtc acattgtttg gttcaatcaa gctgaaaaaa 7080 gataaatatc ttattttagc tacagaaaaa tctagtgcag cccaaatttt gggacataaa 7140 atatatcgtg ttcataaatt tgaagttatt ccctatcgta acctactagc tgacgatcaa 7200 gatgaattgg atttatacaa tttgttacaa aatcatttga aaacaggacc tttttacttc 7260 tcgtacacat gggaccttac taactcccta caacgttctt gtacggatga gggaaaggcc 7320 tcacctattc ttcgaagtga taaacgattt ttttggaacg agtttgctag taaagatttc 7380 attgatctta tcggtgccca ttctgaagta tcacttttca ttacgccaat gatttacggc 7440 ttcatcactt ctgcttccac tattgttaag ggacgaacaa tcacgttagc attaatatct 7500 cgacgctcta aacaacgcgc cggtactaga tattttacca gaggtttaga cgagaatgga 7560 aaccccgcca acttcaatga aactgagcag attactatcg tttcagacga aaagtcagag 7620 gtcacttatt cacatgttca gacccgcggt agtgttcctg ctttttgggc agaggttaat 7680 aatcttcgct ataaaccatt gatggttgca aattctgctt caatggctgc agccgctgca 7740 aaaaagcatt tcgacgagca aatatccata tacggtgacc aggttgtagt taatttggtc 7800 aactgtaaag gacatgagct tcctattaaa cagttatatg aaaatgttat acgtcgtttg 7860 gataatcccc atatccatta tcattatttt gactttcata aagaatgtag ccatatgagg 7920 tgggaccggg tttcactcct tttaaatgaa atacaacccg agttagaaga gcaaggctac 7980 actacattag acactcaaaa gtaccgtgtt ttatctcgtc agaatggcgt tgtacgctcc 8040 aactgcatgg attgtcttga tagaaccaat gtggtccaaa gctgtatagg tcgctgggtg 8100 cttacgaatc aacttcgtaa atgcggaatt ataggtgcta cccatcccct tcgttccgtc 8160 attcctcttg ataacatttt ttgcaacatt tggtctgata atgcagatta cattagtctt 8220 tcttattctg gtacaggagc tttgaaaacc gattttacta gaaccggtat tcgaactcga 8280 aaaggcgctt ttaacgattt tgttaactct gctaaacgtt atattttaaa taatttttat 8340 gatggagcac gtcaagatgc ttatgattta gtacttggac agtttagacc cgatgttaac 8400 ttccgatata gattagattt acgtcctctt actattcgtt gtgtccctta tatattattg 8460 gcatgtttaa tccttttctt catgacattg ttttctagat cttcttctac gatccttcca 8520 ccttcaattc ttttgatcct gacatttttg ggaatagttg catctcttta ttactgtttt 8580 gcccacggac tccagtttat caactggcct aggctacttc ttccttcttt tttacgctct 8640 gatatgactc cagaaggcag ggtatttgta attaaccgcc aactcgcttc gaagcataaa 8700 gtttgaatac tgatattctt atgttaaact atgagtttcc ttgtatatac ttatcgttga 8760 tagttgtact cttgtaacct ttgggtactt gatttgtcga tggtaaggat tttcatcgga 8820 tgaaatatat acgattattt atcgtaataa cacatttatt aaagcattat tttcctttgc 8880 gtgctacaga agtgaaatcc ttttgtttga gtaataacaa tgtacaaact tatgcccgta 8940 cactgaaatt tattcctaga caacataaag tgttacgcgg acagcttatg cagtcattaa 9000 atatatactg ttttgggttt gtagcgctgc agcaagttta gactaaggtt aatagtaact 9060 ttacaattcg ggcgatatat aatttgaaat cattatttgt cgacaataag catacgattc 9120 aaatatagac ttttgtaaaa taatctaatg tattcacatt catcttctat aaagtatcct 9180 tcaaatcaac aaaacgccga caactcagcg ttcaaagtct tcatattaac atactcattg 9240 caatgcatat ctgatttaaa attaaatggt aaatatagtg aagcaaccaa gtatcatgca 9300 aattcccaac gcaaaacaaa ttaacgcaat tgtaaaaaaa attgcaaaat agaaggtggc 9360 aacgctatcg agattttcat ctgtgaattg atctaaatat cggaaacgtt gaattccaca 9420 cttgagcagt gccaactaaa acattgacca tgtcaattgc aaagaatata gaaaacgatc 9480 ctagcaaagg gtgggttgtt caaaaattcg gtggaaccag tgttggaaag ttcccaatta 9540 aaattgctgt tgatgttgca aagtgagtat tttgtttaca gtttatatga tggttcgagg 9600 agtatggtca tcgtctgaat ctagcaggtt caaaaatatt taagaagtca agagaacttt 9660 ttcctgaatg tgcgttagat tggagttttc atgctagaat gcccgaaatt atttaaaaat 9720 aagatatttc atgtgttgaa ttatgcttgg gaatattggc taattaggtt tttttgaatc 9780 gaattcaaaa tgagagaaag gagataaaag aggttttggt tactctttcc actttctatc 9840 gatatgagac ttatatattt aaatgcttac tcctctacaa actgtcgacc attttagacc 9900 gttaaattac aaattactaa ataatttatt tagggaatac ctaagtacta agcgcgtagc 9960 attggtatgc tctgctcgca gcacagatac caaagcagaa ggcactacta ctagacttat 10020 tagagcaaca gaagcagcat tgcgacctgc tgtaggttct gtgcatgatt tggttcgtat 10080 tattgaaact gatcatgttc aagctgctcg tgatttcatc caggatgttg gcattcaaga 10140 cgaacttatt gatgcttttc atgcagactg cgttgaattg gaacagtacc taaatgctat 10200 tagagttctt tccgaggttt ctcctcgtac tcgtgatctc gtgattggca tgggggagcg 10260 tttaagttgc cgatttatgg cggcagtttt gaaagatcaa gggatcgatt ctgagtttat 10320 tgatatgagt catataattg acgagcaaag agagtggagg aatcttgatg catcctttta 10380 cgcatatctt gcttcccaac ttgctagtaa agttaccgct gttggaaata aagtacctgt 10440 cgttactggc ttttttggta tggtaccggg tggtcttttg tcgcaaattg gccgtggtta 10500 caccgatttt tgcgctgctt tattagctgt tggtcttaat gctgacgaac ttcaaatatg 10560 gaaggaagtt gatggcattt tcacagctga tccccgtaag gttccaactg ctcgacttct 10620 tcctctcatc acacctgaag aagctgctga acttacttat tacggtagtg aagtcatcca 10680 tcccttcact atgtcccagg ttgttcacgc tcgtattcct atccgaatta aaaacgttgg 10740 caacccacgt ggaaagggaa ctgttatttt tcctgataca atttcacgtc atggtagtgc 10800 tacacctcct catcctccta aaattatgcc cgatgatatt tctgctagcc tcgctaacaa 10860 aggcgctacc gcggttacta ttaaagacac cattatggtt attaatattc aatcgaatcg 10920 taaaatatct gctcatggtt tcttagcttc catatttgcc attcttgata agtacaaatt 10980 ggctgttgac ttgattacta cttcagaagt tcacgtctca atggcgcttt acgaagagtc 11040 tgatgacggt aatatgcatg aggcattcgt tgaattgcgt cgattgggaa cgcttgatat 11100 tctccatggt ttagctattc tatctcttgt tggtaagcac atgagaaaca ctaccggtta 11160 cgctggtcgt atgttttgca aacttgctga agcccaaatc aacattgaga tgattagtca 11220 aggtgctagt gaaatcaaca tttcatgcgt tattgacgag aaaatggctg taaaggctct 11280 taacgttatt cataaagaat tgcttgaacc cttagcttta catgaagttc cgtcacaggc 11340 ctcgatgttg gttgaaaagc cttggcttta cagtgcttaa acgtactgta accttgaaag 11400 tcaatttaaa aaataaaaaa aaagtgttgt cttgccttca tttttttgtt ctttttgtct 11460 ttaaatattt tacattctct attttaaaat taccgtgagt tttattttac tcattattat 11520 tatttgtacg tttataaata aatattgact acataaaatt aatattttat aatatatctc 11580 aaaaattgat attcatcttc tttatctccc agtcgaaaaa atgttaagca aaagtgtatt 11640 tattatataa aaacgatcag cttcaattaa attgaacacg aacctaatcc atggatacag 11700 taaaatacaa tgaactcatt ttaagaaaca aaaagtaaat gacccaaaat aatctattac 11760 tatgattact gtttattaaa cctagttttc aacctttaat tttttcctct tttcaatatc 11820 cctcttccga ttgcgaagcg cattgttgta gttttcgttt ttgctatttt cgtttttcaa 11880 cttactgtaa agctttctct gtttattact catcatcatt ttggataact cctttgcctc 11940 tttttcttct ttttcttctg cagtcaaagt atcacgttga cgcttcttag tctttttcgc 12000 ggacttagaa ttctgtttaa catattcaga ataagcgaca ccgcctgctt ctgcctccag 12060 ctctcgttga tgttctaagt cttcctcttc agcgtcatca atttgttcaa cattttcagg 12120 ctcgtcattc ttcttactta tgggcactgc ttcgccagaa atattatcat caagagcttc 12180 ggaaacatcg tcgttctctt cagcagaaag ttcagcttca ggatcgtagt cattttcacc 12240 tactttaaca aatggactaa gatgaggagg gagcgtagcg ccacaggcat acaagtctgt 12300 cctttccaag attcctttgt tgatagagtc gtatacccat tgtggttgaa tatatatcct 12360 accttcgtac ttctgtgaaa tatgaggacg atcacatata tgatgagtaa tcacaggatc 12420 agattctgaa aatggagaac ctgatccgag aattggatcc catccaactt taccaccaaa 12480 ggcacgaatc acaaattcca gagaaaaacg ggggacttca cgagaaagga aaaaagtaaa 12540 attagaaaac aacgaggtat tagatgatga aatatgtgat actaggcttt tggaatcctc 12600 attatctgca ccatcagctg gtttaaactc atctaagttt tcctccgttt caggttcctc 12660 atcagcatcc tcagtagttt tttccgactg ctcaacgacg ttcgcatcac tattcacaat 12720 atctcttatt ttacttttta aagtagcaat attcttacga gcatttttgt tattaccatg 12780 gacgatagcg ggtaaggaag aagactcctc taactcataa gctgctaaac cagcggcaga 12840 ttcgctttta gcaacatcaa tcttaggggg ataacgaagt cccaaggtat tatataactt 12900 gaaatttaca aaccccataa gtgcttgata aaattccaaa aaagtgtgca tgatacgaaa 12960 atcaacatcg gtaggaacag attgagcaaa tttgtaggga acaatccagg tgatttgctc 13020 accaaaaatc tcggcctgat aataaattcc tttaatagag aggaaagctt tacgaaggga 13080 atttgaccga attacatagt gttgaaattc agcacataat ctttcacaat tagcgacagt 13140 agcggcacca atcttgtcgg taacaggcat agttgaaaat aagaacagca tactaagagc 13200 atcatcaata tctttcaagg catcatggaa ggttgggtaa cgctctttaa tgatatgatc 13260 caaagaataa gtgggttttc tggcctctaa acgtttagca gtttctaatt ccccttttcc 13320 caatgctttg ctaagcttgc gagcgaacac tttgtactcg cgaaacttct gtacaatagg 13380 ctcatgtaac aaatactgga tatccttagt ataatctatt atatttatta gtacataatt 13440 tcattctttt agttcatcaa aaaaagacta gcccatgata aaattgacca ttcggaaaat 13500 gctttttata ccaaacgtcc atgttcagat agctatgatt ccggtaaaaa ttgatgctat 13560 tagacttaca gaaagtgact ggagcagtgg agcctttatt tgcttttttc ttattttttg 13620 gctcacgagg ataaacaccc tttaaaatac aaatacgacg aaaatcagca agagtgagct 13680 gaagcttctt aagcgcttga tttctcgtaa tgtagatacg agctgcacct gctttccctg 13740 ttttcaatta gaaaattttt ttacaagcta catacctttc tgttttaccc tcgccatttc 13800 ttcaatttga tggctttttg cagaaagagg gtgttggaag aattttgcaa aatccaaaat 13860 ccttcataca gactagctta gctctctgca ctgcgtaaat ggtgttagat ggtagtatta 13920 tctcacagcg ctaaattttc ttatactatt ttacgttaaa tttcgctata tttgtgtttt 13980 tccgtacttt tgagataaat 14000 //