ID SPAPYUG7 standard; DNA; FUN; 10679 BP. XX AC AL136521; XX SV AL136521.2 XX DT 19-JAN-2000 (Rel. 62, Created) DT 31-MAY-2002 (Rel. 72, Last updated, Version 3) XX DE S.pombe chromosome I plasmid pYUG7. XX KW pyrroline-5-carboxylate reductase; RNA polymerase II subunit 9; rpb9; sin1; KW stress activated map kinase interacting protein; KW transcription initiation factor IIE alpha subunit. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-10679 RA McDougall R.C., Rajandream M.A., Barrell B.G., Saunders D., Harris D.; RT ; RL Submitted (17-JAN-2000) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; O74635; O74635. DR GOA; Q9P3W1; Q9P3W1. DR GOA; Q9P7Y7; Q9P7Y7. DR SPTREMBL; Q8X1T0; Q8X1T0. DR SPTREMBL; Q9P7Y5; Q9P7Y5. DR SPTREMBL; Q9P7Y8; Q9P7Y8. DR SWISS-PROT; O74635; RPB9_SCHPO. DR SWISS-PROT; Q9P3W1; T2EA_SCHPO. DR SWISS-PROT; Q9P7Y7; PROC_SCHPO. DR SWISS-PROT; Q9P7Y9; SIN1_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC The 3' end of plasmid pYUG7 overlaps clone c1782. XX FH Key Location/Qualifiers FH FT source 1..10679 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="plasmid pYUG7" FT /map="IR" FT CDS join(<1..17,59..200,329..1288) FT /codon_start=1 FT /db_xref="GOA:Q9P3W1" FT /db_xref="SWISS-PROT:Q9P3W1" FT /note="SPAPYUG7.01, len:372, SIMILARITY:Saccharomyces FT cerevisiae, T2EA_YEAST, transcription initiation factor FT iie, alpha subunit, (482 aa), fasta scores: opt: 333, FT E():1.2e-12, (26.0% identity in 411 aa)" FT /gene="SPAPYUG7.01" FT /gene="tfa1" FT /gene="SPAC458.07" FT /product="transcription initiation factor TFIIE alpha FT subunit" FT /protein_id="CAB66310.1" FT /translation="DRLLAIQSRTEMKEGQQRQYHTTYFYIDFCSTIDSIKWRMHQLVK FT TVEDRMRNDFDSKGYVCPFCNKKFSSLDVLSLVTNEGTFACNVCGTELKDDEESAEMMS FT SQKRLGKLMGQVNGIIDALKRVDEIVVPQNNFQSALEHAVPVSLDTQNLSQQNLSKSNS FT DVRLSTSSPSITVDFSADKETDEKRERNCDKQVKAAQNILPEWHATSTISGSITRAGAK FT DAALHSFRTETVNEVQDTKTDITSEKSALDAYYATLRAKQKEESEFMDSENVDDEEDDD FT FLDVTTATSLQNKSTDYGSVKRKTENLNSDSDIQNKRTKSIEENNSLPPIVSTNGITDG FT DTEMQESKKNVIINGFNEDDEDDEDEADFEDV" FT misc_feature 18..23 FT /note="gtacgt, splice donor sequence" FT misc_feature 47..58 FT /note="ctaacctttcag, splice branch and acceptor" FT misc_feature 201..206 FT /note="gtaagt, splice donor sequence" FT misc_feature 317..328 FT /note="ctaacttagcag, splice branch and acceptor" FT CDS join(complement(3455..3477),complement(1512..3395), FT complement(1382..1472)) FT /db_xref="SWISS-PROT:Q9P7Y9" FT /note="SPAPYUG7.02c, len:665" FT /gene="sin1" FT /gene="SPAPYUG7.02c" FT /product="stress activated map kinase interacting protein" FT /protein_id="CAB66311.1" FT /translation="MELTREKVLLLTFLRMQYSHILPDSIENRVISTEAPEWELDKSLQ FT DLLIHDYDYSKTSFSSSPPIVANDTVSNVRKPSDTKQVNGAGGQVNHSRAEDSDYATSD FT LSESSDVGDDDNSCIFSFSKVPMQKDVASIKEEERLDPKISTLNNIDAIANLKLTNMVE FT SSQAVNLTSSKQSSINQQSSVSTDYDDLRSISEESFHLSQGEIPLTFPMNSSLTDTEAD FT AVVAVDALFPGKQRGTHNTVNKARSVSNAKAPTSALRALLEHKENSSQNGPLAENFATF FT SGHAESNALRLNIYFPSSESPSKPLFVELRKNVLVSEAIGYILLQYVNQQLVPPIEDEA FT QNPNYWNLRIVEDDGELDEDFPALDRVGPLSKFGFDAFALVKATPAQIKENQAAYPFKS FT KHPTSIPEANNKTHIRHTSSTSSQSQKQAQDVKDTLNTSHVVQVRLPPYGDNARFCNIE FT ISKTTRLAMVLNQVCWMKQLERFKYTLRVAGSDTVLPLDKTFSSLDGNPTLELVKKKVR FT DKKGSTQQLPTSSPQNSVYGSIKKDAQSSTYNATDIMSSNTYQEFLVWKRQPVSFMGRH FT ERLLAIDGEYVHIMPSESKNIFETPKTSSIHAGSIILCKQSKKSPCNFKMIVSKNRETK FT RYDFEVLSALEAAIIVSRIRALMNTVKKIN" FT misc_feature complement(1473..1485) FT /note="ctaacgagttcag, splice branch and acceptor" FT misc_feature complement(1506..1511) FT /note="gtaaga, splice donor sequence" FT misc_feature complement(3396..3415) FT /note="ctaatacgtttattttacag, splice branch and acceptor" FT misc_feature complement(3449..3454) FT /note="gtaagg, splice donor sequence" FT CDS complement(4328..6442) FT /db_xref="SPTREMBL:Q9P7Y8" FT /note="SPAPYUG7.03c, len:704" FT /gene="SPAPYUG7.03c" FT /product="hypothetical protein; contains pleckstrain FT homology dopmain" FT /protein_id="CAB66312.1" FT /translation="MTASQQDQHAKMYLADIHRALRIPSPIPSTDYECSDYASTIASIS FT RESTMRNFNRSNISSTAPSFAESEDAEDGDSFPYDQTLSNSSSFDDHQSLLPFSTEVRR FT TPTYSVMNETDSSSTSVEDVNKENILSLNDSCLIKLSDDEASNKSSRSSTPRNSIKSNS FT SNQGHGDIPIPKKNPARSVCNSKLFNEDTLPAEFEEVSISPPVKLELPTHSHNSSDTSF FT TNSIVSSVSDMVGLGEGINSIASFGFSEDSSSFQDIKTPPRLSFADENRENCRTDIYRS FT DSIHEYEEPLTSSITSLDSPHVLDENAPIPLLPKVVSLPDPRFTNVLSAFDALTRTYLL FT RQNSKVVHATSQKQEMQTSRRVVNSCYMPESLSRNLSSSLQQTGGSGRLFVRLMEIRNL FT TIPLASGMTTRFTYTISGKHIQVPWNALHSTTKIENEYTFDESISSSIVCTLRAAYDPP FT KVRTRSTLGKVFSTNKRKSMTTDPVSEALHGFVSEDGTFGEVTINTDSVSRTALGRCQS FT MVLPIMNKWTVDPAAKDVKPLPRKVGELEIHVFFLPALPVSLKELPASIESAMYDLKLA FT EWDRTLLCDGYLCQQGGDCPYWRRRYFQLIGSKLVAFQQFSKVRRATIDLSEATHIVDD FT NHYSDEEELEGYLYFESGFRIIFSNGDYIDFYAETVGEKDEWMSTLRQHLGQCSMVHKN FT WTKSFLSLSF" FT CDS join(complement(7481..7521),complement(7347..7413), FT complement(7174..7223),complement(6999..7131), FT complement(6873..6923)) FT /db_xref="GOA:O74635" FT /db_xref="SWISS-PROT:O74635" FT /note="SPAPYUG7.04c, len:113" FT /gene="rpb9" FT /gene="SPAPYUG7.04c" FT /EC_number="2.7.7.6" FT /product="DNA-directed RNA polymerase II subunit" FT /protein_id="CAB66313.1" FT /translation="MSNFQYCIECNNMLYPREDKVDRVLRLACRNCDYSEIAATSKVYR FT HELQSSNVENTTVSHDASTDPTLPRSDKECPRCHQHEAVFYQTHSRRGDTMMTLIYVCV FT HCGFAFEEQ" FT misc_feature complement(6924..6936) FT /note="ctgacttaattag, splice branch and acceptor" FT misc_feature complement(6993..6998) FT /note="gtgtgt, splice donor sequence" FT misc_feature complement(7132..7143) FT /note="ctaaatttgtag, splice branch and acceptor" FT misc_feature complement(7168..7173) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(7224..7236) FT /note="ctaatttgtatag, splice branch and acceptor" FT misc_feature complement(7341..7346) FT /note="gtaagc, splice donor sequence" FT misc_feature complement(7414..7431) FT /note="ctaacatgaaataaatag, splice branch and acceptor" FT misc_feature complement(7475..7480) FT /note="gtacgg, splice donor sequence" FT CDS 7983..8831 FT /db_xref="GOA:Q9P7Y7" FT /db_xref="SWISS-PROT:Q9P7Y7" FT /note="SPAPYUG7.05, len:282, SIMILARITY:Saccharomyces FT cerevisiae, PROC_YEAST, pyrroline-5-carboxylate reductase, FT (286 aa), fasta scores: opt: 559, E():1.9e-28, (34.5% FT identity in 284 aa)" FT /gene="SPAPYUG7.05" FT /product="Delta 1-pyrroline-5-carboxylate reductase" FT /protein_id="CAB66314.1" FT /translation="MSGFCVLGCGTMGKALLTGIFDSIAENGNDVSDEIIIPNKFYACV FT KFPKEKEDVQKLFGDRVKVVMGAKENAEMAAISNVLLLSCKPQAAEDVLNSPKMKEALK FT GKLILSILAGKTISSLQSMLDESTRVIRIMPNTASRIRESMSVICPGPNATEEDIKFAE FT WVFNGIGRSMKLPEKLIDAATAVCGSGPAFVATMIEAMTDGGVMMGIPFPQAQELAAQT FT MVGTGRMVLQGQHPAMIRNDVSTPAGCTISGLLALEDGKIRSTIARGIEQATKTASGLG FT K" FT misc_feature 7998..8777 FT /note="Match to PF01089 P5CR, Delta FT 1-pyrroline-5-carboxylate reductase Score 263.19" FT CDS 9372..9977 FT /db_xref="SPTREMBL:Q8X1T0" FT /note="SPAPYUG7.06, len:191, SIMILARITY:Arabidopsis FT thaliana, AAF14657, f23a5.4 protein., (231 aa), fasta FT scores: opt: 368, E():5.5e-17, (35.8% identity in 187 aa)" FT /gene="SPAPYUG7.06" FT /product="hypothetical protein; conserved domain in FT Arabidopsis; C elegans, Drosophila and human, contains FT motif Y.G..YHL{IM}.{KR}NCNHF; one of the human protein FT PNAS-4 is human acute promyelocytic leukemia cell line FT NB4's apoptosis-related gene; Pfam-B_13142; no apparent S. FT cerevisiae ortholog" FT /protein_id="CAB66315.2" FT /translation="MKVYINVYDLMPDSPVNKLAWTLGLGIYHTGLVLEGKEYAFGAHE FT IPGSTGVFATMPRPPLEGCRWRCSIALPNCTLPKPDVDRILIRLSQEFTGLSYSLLERN FT CNHFTNAAAIELTGSPIPSFLNRISRIGLAFPTITNALLQHGQKNTSDVDDSSDSSSDV FT DEETLIVSKSKKAHKDIPKFSAPPPSADLNNLITDSLP" FT misc_feature 9782..10679 FT /note="nominal overlap with cosmid SPAC1782, EM:AL158056 S. FT pombe chromosome 1" FT CDS 10196..>10679 FT /db_xref="SPTREMBL:Q9P7Y5" FT /note="SPAPYUG7.07, len:173, SIMILARITY, some at N-term FT to:Saccharomyces cerevisiae, YHD0_YEAST, hypothetical 210.4 FT kD protein in gut1-rim1 intergenic region., (1868 aa), FT fasta scores: opt: 212, E():1.7e-07, (33.1% identity in 121 FT aa)" FT /gene="SPAPYUG7.07" FT /gene="SPAC1782.01" FT /product="conserved hypothetical protein; similar to S. FT cerevisiae ECM29" FT /protein_id="CAB66316.2" FT /translation="MAENELRLLNNAELKLALAESEDSFQSLVSVFLCPILLKLDSPHE FT SVRNKTISIANHIMTRLNNNAQAILPLEALVSQYVEANQPLRKRFLLAFISIGEKRIPC FT SENLALLQICLNHVNEYPLVLLTLTIRLLRFSKPTSAITCSNDVILSLSSFYLIQKD" XX SQ Sequence 10679 BP; 3392 A; 1903 C; 2061 G; 3323 T; 0 other; gatcgtttat tggcaatgta cgtgaaggca attccatgac cagctgctaa cctttcagtc 60 aaagtaggac ggaaatgaag gaaggccaac aaaggcaata tcatacaacc tatttctata 120 tcgatttctg ttctacgatt gacagcatta aatggcgtat gcaccaatta gtgaaaacag 180 tagaagatcg aatgcgaaat gtaagttcct tttttaattg ggcctttttt cataaaaggt 240 ttaccatatt gtttccttct ttttgcttag tgttttaccc actactttta cgaatctctt 300 attatcgtca ctttcactaa cttagcagga tttcgattct aaaggctatg tttgtccatt 360 ttgcaacaaa aagttttcta gccttgacgt tttgtctttg gtgaccaacg agggaacttt 420 tgcttgtaac gtttgtggaa ccgaactcaa agacgatgag gagagtgcag aaatgatgtc 480 tagtcagaaa aggctaggaa aactgatggg acaagttaat ggtataatcg atgcattgaa 540 aagggtggat gaaattgtcg taccacaaaa caatttccaa tctgctttag aacatgcggt 600 tcctgtttcg ttagacaccc aaaatttgtc gcaacaaaac ttgtcaaaaa gtaattcaga 660 cgtccgtctt tccacctctt cgccatctat tacagttgat ttctctgctg ataaagagac 720 tgatgaaaag cgtgaaagga attgcgacaa gcaagtcaaa gctgctcaaa acattcttcc 780 cgaatggcat gcaacatcaa caatttctgg ctccattact cgtgctggag ctaaagatgc 840 cgcacttcat agttttagaa ctgaaactgt taatgaggtt caagacacta aaacagatat 900 tacttctgaa aagagcgcct tagatgctta ttacgcaaca cttcgtgcaa agcaaaaaga 960 ggaaagcgag tttatggaca gtgaaaacgt agatgatgag gaggatgatg acttcttaga 1020 cgttacgacg gctacctctc ttcaaaacaa aagtactgat tatgggtcgg tcaagcgtaa 1080 aaccgagaac ctaaattcag atagtgatat ccaaaataaa agaacaaaat cgatagaaga 1140 aaacaattca ttaccaccta ttgtttctac aaatggtatt actgatggtg atacggaaat 1200 gcaagaaagt aaaaagaatg ttattattaa tggatttaat gaggacgatg aagacgatga 1260 agatgaagct gattttgaag atgtttaata aaaatgacat aggggagaga gcaatgtgat 1320 accaaaaaac aaaggtgttt atacctatgt attcatagaa tctttttgta ataaataaat 1380 gttaatttat ttttttaaca gtattcatca gtgcacgtat cctgctaact ataatggcag 1440 cttccaaggc ggacaaaact tcaaaatcat acctgaactc gttagcttat tagcgttaaa 1500 aaatttctta ccgcttagtt tccctattct tggacacaat cattttaaaa ttacatggtg 1560 attttttaga ctgcttgcat aaaataatcg atccagcatg tatactggac gtcttaggcg 1620 tttcaaatat atttttggat tcagacggca ttatgtgaac gtattctcca tcaatagcta 1680 gtagacgctc atgtcttccc ataaatgaaa caggttgtcg tttccataca agaaattctt 1740 gataggtatt gctcgacata atatctgttg cattgtatgt tgaagattgt gcatctttct 1800 taatagatcc ataaacggaa ttttgtggtg aggaggttgg caattgttgg gtacttcctt 1860 ttttatcgcg taccttcttt ttaacaagtt ctagagttgg atttccgtct agtgaactaa 1920 atgttttatc aagtggtaaa acagtatcag atccagcaac tcgcagagta tacttaaatc 1980 gctccaattg cttcatccaa cacacctggt tcaacaccat agccaatcta gtagtttttg 2040 atatttcaat attgcaaaat cgagcattat ccccgtatgg gggaagtcgt acctgtacga 2100 catgagaagt attaagtgta tctttgacat cctgagcttg cttttgtgat tgacttgaag 2160 ttgaactagt atgccgaata tgcgttttgt tattggcttc aggaattgat gttggatgct 2220 tcgatttaaa cgggtaggca gcttgatttt cctttatttg ggcaggagtg gctttaacta 2280 aagcaaatgc gtcaaaacca aattttgata atggacctac acggtccaaa gcgggaaaat 2340 cttcatctag ctccccgtca tcttcaacaa tacgtaaatt ccaataattc ggattttgag 2400 cctcatcttc tattgggggc acgagttgct ggttaacgta ttgaagtaaa atataaccga 2460 tagcctcaga gaccaaaaca ttctttcgga gttctacaaa taagggcttt gaaggacttt 2520 cgctcgaagg aaaataaatg tttaaacgga gggcatttga ttctgcatgt ccagaaaaag 2580 tagcaaaatt ttcagccaat ggcccattct ggctactgtt ttctttatgt tcaagtaatg 2640 cacgaagagc agatgtagga gcctttgcgt tcgaaacaga tcttgcttta ttgactgtat 2700 tgtgtgttcc gcgttgctta ccaggaaaaa gagcatcaac cgcaacaact gcatcagctt 2760 cagtgtcagt taaggaagaa ttcattggaa aagtaagagg aatttctcct tgacttaaat 2820 gaaatgattc ctcagaaatc gaccgtagat catcataatc cgtagaaaca ctgctttgct 2880 ggtttatgga agactgtttg gacgaggtta aattcactgc ctgcgaggat tctaccatgt 2940 tggtaagctt aagatttgcg atagcatcaa tattatttaa tgtggaaatt ttggggtcca 3000 gtctttcctc ttcttttata cttgcaacat ccttctgcat tgggactttg ctaaaagaaa 3060 atatacacga gttatcgtca tcacccacat ctgaagattc ggataagtca gaagtagcat 3120 aatcagaatc ttcagctcga gaatgattaa cttgaccccc agcaccattt acttgtttag 3180 tatcactcgg ctttcggaca ttggatacag tgtcattagc gacaatcggg ggacttgaag 3240 aaaacgaagt tttagaataa tcataatcat gaatcaacaa gtcttgcaat gatttgtcca 3300 attcccattc cggggcctca gtagatataa ctcgattttc gattgagtca ggaagtatat 3360 gagaatattg cattcgcaaa aatgttaaca aaagactgta aaataaacgt attagtttgt 3420 ataagtttca taggaaaaaa aatagtatcc ttacactttc tctcttgtta attccattct 3480 gagtccttat tatatcgcat ttacagactt tataaaatat ttaatttcaa cgaagtttga 3540 atacttagcg accatacttt ttatggcacc ttaatataga aaatttgtaa actcaattat 3600 gtgaaacgtt ggtgacggac gccgcgtgct ttatttcagt tgctatgtat cccccgctaa 3660 gcatttaatt aagtgttggg ggtaacaccg taaagtacca ccaaatttca aaagacagca 3720 aaatatgaac gaaactatta attcaaacag ttattaactg aagtacaaaa acgctagaca 3780 atgaaaaaaa gtgatctcat atacgtttta gatattgcga aacagctaaa aatggtattt 3840 gaactatata gcaattacgg tattaattat ttacagaata atgtaattaa attattgtgg 3900 aatttttatt ttttgaagtt tctcaaatgg caagcttacg acttaataaa ttcactcgac 3960 aacgccaagc tagagtattt taaggaattt gatttattta caaagccaag ataaacgttt 4020 tgagacaact tattttgaca acgtttcttc ggatcaaggg aaactttcaa aaatgaagta 4080 ttttgcaact gaagtataaa tatacatggg gagtagtaag taattgctat ccgattttta 4140 acagcttata taaaacgagc tcatttcaac cgaatctagc ttctcgatgg tagataaaat 4200 gaacattatg tattatgcga gggaaacaac aaaaccaatg aaaaatgcaa gacgatatag 4260 ataaaggaga agataaagac caaatgtgat ttaaatagaa aaagtgaggt cgaagcaaat 4320 ggtcaattta aaaactcagc gaaagaaatg atttggtcca atttttgtga accattgaac 4380 attgccccaa atgctgacga agtgtagaca tccactcatc tttttcgccg acggtttcag 4440 cgtaaaaatc gatgtagtcc ccattactga aaatgatacg gaaacccgat tcgaaataca 4500 gatacccttc tagttcttct tcatcactat aatggttgtc atccacgata tgtgtggctt 4560 cagacaaatc aatcgttgct ctgcgaactt tagagaattg ttgaaaagct actaactttg 4620 atcctattaa ttgaaaatag cgacgacgcc aataagggca atccccacct tgttgacata 4680 gataaccatc acacaataaa gttctatccc attcagcaag ctttaagtca tacatggcag 4740 actcgattga agcgggaagt tctttcagag agacaggaag cgctggtaag aaaaatacgt 4800 ggatttcgag ttctcctact tttcgaggga gaggcttgac atctttagct gccggatcaa 4860 cagtccattt gttcatgatt ggtagaacca tagattgaca acggcctagt gcggttcggc 4920 ttacagaatc agtgttaatg gtaacttcgc cgaaagttcc atcttcagaa acaaatccat 4980 gaagtgcttc tgaaacgggg tcggtagtca tagactttct cttatttgtt gaaaatactt 5040 ttccaagtgt agaacgagtg cgaaccttag gtggatcgta agccgcacgg agcgtacata 5100 caattgaaga actaatactt tcatcaaaag tatactcatt ttcaatttta gtagtagagt 5160 gtaaggcgtt ccatggtact tgaatgtgct taccagagat tgtataagtg aacctagtgg 5220 tcatccccga tgccaaagga atagttaagt ttctgatttc cataagacgg acaaacaatc 5280 ttccactccc gccggtttgt tgcaaactac tggacaaatt tcgcgataac gattctggca 5340 tataacaaga attgacaacg cgccgcgaag tttgcatttc ttgtttctga ctagtggcat 5400 gtacaacttt agaattctgt cgtagcaaat atgtcctagt caaagcgtca aaggctgaaa 5460 gaacatttgt aaagcgagga tctggtaaag aaaccacttt tggaagaagc ggtatcggag 5520 cattttcgtc aagaacatga ggggaatcta aagaggtgat ggagctcgta agtggctctt 5580 cgtattcatg aatagaatct gaacggtaga tatcagtcct acaattctct cggttctcat 5640 ctgcgaatga taagcgagga ggtgtcttta tatcttggaa cgaggacgaa tcttcagaga 5700 aaccaaaaga tgcaatactg tttatacctt cgccaagacc aaccatgtca ctaacactgc 5760 taactatact gttcgtaaaa ctagtgtcag atgaattatg agagtgagta ggtaactcaa 5820 gtttgacagg tggtgaaatt gaaacttctt caaattcagc tggcaatgtg tcctcgttaa 5880 aaagctttga attacaaacg gaacgagcag gatttttttt aggaattggt atgtcgccat 5940 ggccctggtt agatgaatta ctctttatcg agttgcgtgg agtcgagcta cgactgcttt 6000 tatttgaagc ctcatcatca gataatttga tcaaacatga atcgttcaat gacagtatgt 6060 tctctttgtt tacgtcttca acacttgtac tactactatc cgtttcattc atgacagagt 6120 aagttggggt cctacgaact tctgtagaaa aaggaagaag agactgatga tcatcaaaac 6180 tggaagaatt tgataacgtt tgatcataag ggaaactatc gccatcttca gcatcctcag 6240 attcagcaaa agaaggggcc gtagacgaga tgttactgcg attaaaattt ctcattgtac 6300 tttctcgaga tatcgatgcg attgtagagg catagtcaga acattcgtaa tcagtacttg 6360 ggatgggaga aggaattctc aatgctctat ggatgtcagc taaatacatt ttagcatgct 6420 gatcctgttg agaagcagtc atcaacatta tggaaagcct tggaatttaa cagctctgct 6480 gaaattagaa tataaaaaaa aataaaggca caaagaatta agggttttta tttaattggt 6540 attcggatta caaggctatt ccgtatggat tattgtatac aaataactga aacagtttca 6600 gtatattcca gaaggtacac cgaatgtgaa ataaagaaat tcaagtgttt tggtaggcgc 6660 gttgcttaat ataaaggaag gaggcgagca tatgattgag aggctggtaa atccattttc 6720 ggcaaaggtg gctggtatca ctcgaaaatc cagttttcca gcacagaagc gagagagtgg 6780 ttacatcaag cggatcattt aaaccgaagt ctaagagcca ttggtggacg cagctagttt 6840 tacaatccct tgttagaccg aattgtcgca tattactgtt cttcaaaagc aaatccacaa 6900 tgtacgcaaa cataaatcag agtctaatta agtcagtaaa attgttttta aacctaaata 6960 ttaaaattgt tttctcaatg aaacaatgcg aaacacacca tcatagtatc accccgacga 7020 gaatgagtct gataaaaaac tgcttcatgt tgatgacaac gcgggcattc tttgtctgat 7080 ctaggtaaag tagggtccgt tgaagcgtcg tgactgaccg tcgtgttttc tctacaaatt 7140 tagtgattat tcgaaggatg aaatctaact tacacattgg agctttgtaa ctcatggcga 7200 taaactttac tagtagcagc gatctataca aattagctga tgagatattt aaaacttcca 7260 aatgatgagg aaaaaagtaa tcgaaaagaa cttcgaattt ttttcttgaa gtgaataaac 7320 ccagtaggag aaaaaaacaa gcttacctct gagtaatcac aattacgaca agctagcctc 7380 agaacacgat ccactttatc ctctctaggg tacctattta tttcatgtta gtgttttcaa 7440 acaattttca gtgtcatctt tttgagaaac taatccgtac agcatattat tgcattctat 7500 acaatattga aaatttgaca ttttaaaaaa gcaaacaaaa gtattttact tcaacgcaat 7560 aaactttcaa aagaacgtgg tggttagtgg atatggaaaa tacagtggac aacagcgtcc 7620 tgatggttca catctataag ttcgaaaaag cttttgttta tctacaacgt ctctacaaga 7680 tttcgttaaa aactgtgtag ctgctttaaa atttatttgc gatatactta atattactaa 7740 ttatatagaa gatatattga ctttaacgtg tagcattatt caaacatgga ctagtcctac 7800 aaacttgtaa catcatactt cagtatctta cattatgcac atcagcgagt aaaacggtaa 7860 tttacagtat gagtttgatt ttggaattaa cgatccctta gcatatgctt tagtcgaatt 7920 tattttcgct ttaaaagaag actacaaaaa tagttaaaca tttttaagca taactttaaa 7980 aaatgtcggg gttttgtgtt cttggttgtg gtacaatggg aaaagcactt ttgactggaa 8040 tctttgattc cattgctgaa aatggaaacg atgtttctga cgaaattatc attccgaata 8100 agttctatgc ttgtgtcaaa tttcctaaag aaaaagagga tgttcaaaag cttttcggag 8160 atcgtgttaa agttgtaatg ggggccaaag agaatgccga gatggctgcg attagtaacg 8220 ttttgttgtt gagttgtaag cctcaggccg cagaggatgt tttgaattcc ccaaagatga 8280 aagaagcgct caaaggaaaa ttaattttgt caattttggc tggcaagacc atctcttcat 8340 tgcaaagtat gcttgatgaa agtactaggg tgattcgcat tatgcccaat actgctagtc 8400 gaatccgtga aagtatgagc gtaatttgcc cgggacccaa cgcaactgaa gaagacataa 8460 agtttgctga atgggtattc aatggcattg gacgttcaat gaaacttccc gaaaagctta 8520 ttgatgctgc taccgctgta tgtggaagtg gacctgcttt tgttgctact atgattgagg 8580 ctatgacaga tggtggtgta atgatgggta ttccgttccc tcaggctcag gaattggctg 8640 cccaaactat ggttggtaca ggtcgtatgg ttttacaagg tcaacatcct gctatgattc 8700 gtaatgatgt ttcaactcct gccggatgta caattagtgg tttgttggca ttggaagatg 8760 gaaaaattcg aagcacaatc gcacgtggta tagaacaagc aaccaagact gcttctggcc 8820 tgggtaaatg atactagcaa attcattttg tgctattaaa tatcctggtt ccaaacatgg 8880 atttgtatat aaaattcttg ggttagtact tctgtttcct ctttaaagct agtttcgtta 8940 tctagttgta ttaaagcgtt gtgacttagt ttcattcaat gattcctctg tttaagcttg 9000 caattctgtt acattactaa taatatgcgt attcgaacag cgagattata tttcattaac 9060 tttttagaac gttgtatgca attaaaccca tttcattgcg attgctatcg tagtgaattt 9120 agctaaaggt attcaatatt gaagaaacgt actatgtttt gattatttta acattgtcat 9180 agtcgtaccg atgtaaacaa aatcaccacc ataaacagct cccgtatttt aaatttttat 9240 ccttaattcg actctacttt tttttattaa aaatacttaa ttgtacaggt atcgaatctt 9300 aaaattcaac ctgcttaagg aggaccaagg aaatttgcaa gttgttcttc gccatccgaa 9360 cgtattcgaa tatgaaagta tacattaatg tgtatgatct aatgccagac agtccggtaa 9420 acaaactagc atggactctt ggacttggta tttaccatac aggattggtt ttagaaggta 9480 aagaatatgc gttcggagca cacgaaattc ctggctccac cggtgtgttt gctaccatgc 9540 caagaccgcc tttagaaggg tgtagatggc gctgttctat tgctttacct aattgtaccc 9600 tccctaaacc cgacgtggat agaattttga ttcgtttgag tcaagaattt acggggttat 9660 catattcttt attagagaga aattgcaatc atttcacgaa tgctgcagca attgaactta 9720 cgggcagccc tatcccttct tttttaaatc gaatttctcg aattggattg gcgtttccta 9780 cgatcacgaa tgccttatta cagcacggtc aaaaaaatac atccgacgtt gatgattcct 9840 cggattcttc ttcagatgta gatgaagaaa ctttaatcgt atcaaaaagt aaaaaagctc 9900 ataaagatat tcctaaattt tccgcacctc ctccttctgc tgacctcaat aacctcatca 9960 ctgattcact tccttaagtc gcatgctgtt agtcagcctt ttaacctacg aaatacaaca 10020 cacacatcca aaattgtaga ttttatttat gccttgttct atcaattaag tgtaaagtca 10080 atttgggact tttttttaat tacttgcttt ctgatatata tctctttatt catctttgtt 10140 tggtatttta ttgtagagtg tttttttatt agtgattata attaactcta caataatggc 10200 tgaaaatgaa ttgagattat taaacaatgc agagctgaag ctcgctctag cggaaagcga 10260 ggactccttt caatcgcttg tgtcagtttt tttatgtccg attttactaa aactcgattc 10320 gcctcatgaa agtgtgagaa acaaaacaat ttcaattgca aaccacatta tgactaggct 10380 caacaataac gcgcaagcca tactacctct tgaagcctta gtaagccagt acgttgaagc 10440 aaatcaacct ttgcgaaaaa gatttctcct tgctttcata tctataggcg aaaaaaggat 10500 accttgttct gaaaatttgg cccttctcca gatttgtcta aatcatgtca atgaataccc 10560 attagtatta ttgacattga caattcgttt acttcgtttt tcaaagccaa cttcggctat 10620 tacatgctct aacgatgtca ttttatctct ttcttcattc tatttgattc agaaagatc 10679 //