ID SPAPB24D3 standard; DNA; FUN; 29314 BP. XX AC AL590582; XX SV AL590582.1 XX DT 12-APR-2001 (Rel. 67, Created) DT 12-APR-2001 (Rel. 67, Last updated, Version 1) XX DE S.pombe chromosome I BAC pB24D3. XX KW 31 glycosyl hydrolase; agmatinase precursor; amino acid permease; KW ATP-binding cassette (ABC) superfamily; DNA-3-methyladenine glycosylase; KW Drug-efflux pump; membrane transporter; NADP dependent oxidoreductase; KW putative transcriptional regulator; ring cleavage dioxygenase; KW Zn_clus domain. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-29314 RA Collins M., Harris D., Wood V., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (12-APR-2001) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; Q92383; Q92383. DR GOA; Q9C0Y3; Q9C0Y3. DR GOA; Q9C0Y4; Q9C0Y4. DR GOA; Q9C0Y5; Q9C0Y5. DR GOA; Q9C0Y6; Q9C0Y6. DR GOA; Q9C0Y8; Q9C0Y8. DR GOA; Q9C0Y9; Q9C0Y9. DR GOA; Q9C0Z0; Q9C0Z0. DR SPTREMBL; Q9C0Y3; Q9C0Y3. DR SPTREMBL; Q9C0Y5; Q9C0Y5. DR SPTREMBL; Q9C0Y6; Q9C0Y6. DR SPTREMBL; Q9C0Y7; Q9C0Y7. DR SPTREMBL; Q9C0Y8; Q9C0Y8. DR SPTREMBL; Q9C0Y9; Q9C0Y9. DR SPTREMBL; Q9C0Z0; Q9C0Z0. DR SPTREMBL; Q9C0Z1; Q9C0Z1. DR SWISS-PROT; Q92383; MAG1_SCHPO. DR SWISS-PROT; Q9C0Y4; AGLU_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC BAC pB24D3 is overlapped at the 3' end by BAC pB1A11, CC EMBL entry SPAPB1A11, accession number AL512486. XX FH Key Location/Qualifiers FH FT source 1..29314 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="BAC pB24D3" FT /map="IL" FT CDS 1..180 FT /codon_start=1 FT /db_xref="SPTREMBL:Q9C0Z1" FT /partial FT /gene="SPAP24D3.01" FT /gene="SPAPB2C8.02" FT /product="putative transcriptional regulator; contains FT Zn_clus domain" FT /protein_id="CAC36897.1" FT /translation="DLNRMYSVNRFFVKLRDIGGDLAEKLASVTENFIHAAENYFAVQP FT AFMADAFDFASFLT" FT CDS complement(542..2173) FT /db_xref="GOA:Q9C0Z0" FT /db_xref="SPTREMBL:Q9C0Z0" FT /label=SPAPB24D3.02c FT /product="putative amino acid permease" FT /gene="SPAPB24D3.02c" FT /protein_id="CAC36898.1" FT /translation="MDETIGMKKEFHDISVGDIEVGESAPVTEDDKMLLNLGYKQEFKR FT EFSLLAVFGQSFGSMGLCPSLVGSMAFSMNCGAGGMVWSWFVGATCLLPIAFALSELAS FT SMPTSGSLYFWTAYLSPPKYRAFLSWFLGYVLALAYSTGFASTIYAAAGLVQATASVAN FT PSYAPTKYEEYGIYVALSFACSALIVLPTKFLARFSSFNVVFQICTILIFIISLAASST FT SETRNTGSYIFGNFENYSGWTNMGWSFILCFTTPVWVLSGFESCATIVEEAKNASKAAP FT IAIISSLTVSLFMGFCIMITIAGTMGHDFSSILNTPYGEPVSQVLYNNLGKRGAVGVSA FT VLIIALCFNCSALCLASSREIFAFARDKGLPGSWIFRKLTPGGIPLNAILLVNLYTIIV FT GLLMLVNVTAISSIFNLAIIAFFISYSLPLVCRLLFNRLNPGKFYCGKFSKPISIVAVA FT WLWFMALMLLFPSYQNPNKVEMNWAIVVLGFTVFFCVGYYYLPKYGGKTFFKGPVKTVD FT ENVTEGVTVDFQADHVSKEDDGKSYN" FT CDS 2937..4094 FT /db_xref="GOA:Q9C0Y9" FT /db_xref="SPTREMBL:Q9C0Y9" FT /label=SPAPB24D3.03 FT /gene="SPAPB24D3.03" FT /product="putative agmatinase precursor" FT /protein_id="CAC36899.1" FT /translation="MGLGFQEKNPVFVKEKQSPFYAVPSNYEEVEFSSIVEPMYSGIAT FT FGRLENVECLSKRSEDFDIAFIGMPFDTGTSYRPGARFGPSSLREGSRRINTKYGAVNV FT PLEINPFKSWAKLVDCGDIPVTTYDILKAMDQLESAYFQLIARKPSSFTDHDGFAKNDT FT VLPRVLSLGGDHTIVLPILRALHRVYGQPISVIHFDSHLDTWAPGLIGDGDEADGINHG FT SYFYFASQEGIMSKDANIHAGIRTPISSFSDYDDDVDCGFKIIEAREIDDLGIDGIVKK FT IRDRVGDNLVYLSIDIDVLDPAFAPATGTPETGGWSSREMRAILRGLQGLKFVGADLVE FT VAPAYDVAEITSLAGAQLLFDIVSMMVKYPLVKEADLSRYMPIHK" FT misc_feature 3135..3206 FT /note="Match to arginase Score 33.96" FT misc_feature 3435..3560 FT /note="Match to arginase Score 24.51" FT misc_feature 3717..3965 FT /note="Match to arginase Score 116.08" FT CDS complement(4590..5276) FT /db_xref="GOA:Q92383" FT /db_xref="SWISS-PROT:Q92383" FT /label=mag1 FT /note="pB24D3.C.cand.6 score = 17.88" FT /gene="mag1" FT /gene="SPAPB24D3.04c" FT /product="DNA-3-methyladenine glycosylase" FT /protein_id="CAC36900.1" FT /translation="MTLDIEEKEEIVTSLTKAEIHLSGLDENWKRLVKLVGNYRPNRSM FT EKKEPYEELIRAVASQQLHSKAANAIFNRFKSISNNGQFPTPEEIRDMDFEIMRACGFS FT ARKIDSLKSIAEATISGLIPTKEEAERLSNEELIERLTQIKGIGRWTVEMLLIFSLNRD FT DVMPADDLSIRNGYRYLHRLPKIPTKMYVLKHSEICAPFRTAAAWYLWKTSKLADYTKP FT VRPKKH" FT CDS join(complement(5677..5802),complement(5441..5677)) FT /label=SPAPB24D3.05c FT /note="231 (-1) 51 129 TR:Q9K3D3 Q9K3D3 BIPHENYL-2,3-DIOL FT 1,2-DIOXYGENASE III-RELATED PROTEIN. [0]" FT /pseudo FT /product="pseudo ring cleavage dioxygenase" FT /gene="SPAPB24D3.05c" FT CDS complement(6516..7466) FT /db_xref="GOA:Q9C0Y8" FT /db_xref="SPTREMBL:Q9C0Y8" FT /label=SPAPB24D3.06c FT /product="hypothetical protein; sequence orphan" FT /gene="SPAPB24D3.06c" FT /protein_id="CAC36902.1" FT /translation="MSASHPGILHEYTERLVAFELVGKSNVTLTSNVTRSLLLFVGGLG FT DGLLTVPYVQELVNPLDEIGWSIVQVQTQSSYIGWGTGSLKRDDEDLHKAVDYFLHIGG FT ADFSTRKIVLMGHSTGSQNVLYYLTQSILPNYLIAGIAQAPVSDREAAYQFNGKEKTKE FT LVDWVKAEYLDKGLGNDVLPRSKVENFFGEVPTSANRCIDLTDVRGNDDFFSSDLSADD FT FAKTFGNLKEISGSTAHSQLILLMSERDEFVSPSTDKAQLLNRFRESIRPTTSNSSLSG FT IIPGATHNVGPKSSPEALKWLINQLITALRSFIDQ" FT CDS complement(8476..9378) FT /db_xref="SPTREMBL:Q9C0Y7" FT /label=SPAPB24D3.07c FT /gene="SPAPB24D3.07c" FT /product="hypothetical protein; sequence orphan" FT /protein_id="CAC36903.1" FT /translation="MKSFVWTLLGALSLGSLTTAYGANASNSSVPTPDNTLVVSYTNTS FT CYTSGPLSPDTRFNRTTRGTFSKVRDALKFRLNGPIHHWDIANELFDTALGVEIIDTQY FT GINNRTSRDWCTAVSALEKGDLIEFAAAFTAFDDVNPTKEVVPDALVGTLALWAKYSYE FT YDLTSIVSLFGKNWTVDELGWGTYIAHSLNEISSNTTGAANATLFIDTQTKSDCYKLAS FT TIESWKYAPLSAFPNYGPFYIYGQCVATFTSGYSPLVEPAFTFASALNTTLNSFPNGTL FT PTQTQVVGDIGVKFLQYFA" FT CDS complement(11651..12700) FT /db_xref="GOA:Q9C0Y6" FT /db_xref="SPTREMBL:Q9C0Y6" FT /label=SPAPB24D3.08c FT /note="pB24D3.C.cand.3 score = 22.94" FT /product="putative NADP dependent oxidoreductase" FT /gene="SPAPB24D3.08c" FT /protein_id="CAC36904.1" FT /translation="MVSNNAVIIKKYLDSTAGYPVIGEHLAFEKREFDLENAQVDEETP FT VLLKNIYTSVDPYLRMRMQSPKHASYIPPLELGKPFYNSTVAKVVKSTLDQYKPGMDVV FT FVSGWEEYTFVSKQALGFLQPINNPYKLPLIDFVGSLGMPSQTAYCGLKHIGKPKAGET FT IYISAASGAVGQMAGQLAKAMGLHVVGSVGSDEKFKICLDSGYDSVFNYKKESPFKALP FT RLCPKGIDIYFENVGGETMDAVLENMNLQGRIIFCGAISQYNNPNPYRVKNLGMVLVKS FT LTIQGFIVANILPQYQEQYFEEMPKLIAEGKIKYKCDVYDGLESAPEAFIGMLQGKNSG FT KTIVKIADE" FT misc_feature complement(11663..12604) FT /note="Match to adh_zinc Score 112.69" FT CDS complement(13614..17804) FT /db_xref="GOA:Q9C0Y5" FT /db_xref="SPTREMBL:Q9C0Y5" FT /label=SPAPB24D3.09c FT /gene="SPAPB24D3.09c" FT /product="putative Drug-efflux pump involved in resistance FT to multiple drugs; by similarity to S. cerevisiae SNQ2; FT member of the ATP-binding cassette (ABC) superfamily" FT /protein_id="CAC36905.1" FT /translation="MSEQEKGKGDLDDPNSKNTKCPDKFEQKVEEYLEVLNELHLTGRT FT SGFCMRNFTVEGAFNPKFQIRSFFAQLLHPINIIFRTGPKRDIIPLVKGFDGYLQPGSS FT LLVLGHEGSGGSTLLKALCGIVEENERLNGSLHYDGLDYKIAHSQFKADLSYCGEGHSK FT VATITVRRLLEFVCSCRLPASKYDHPRSHYIRRICEIIRDAFDLGDFYNHRILRVFNSG FT DQIKVDVAQTMCARPLIQCWDNNMRDFDSISVIDILSRIKVLSHKLGTTLVAIVSQASD FT RIFHMFDMVTLMYEGEQIFYGPTSRLKPYFLDLGFIPAKHSTTVEFVTSLTYPEMRIIN FT KKHQGFIPSTPAEFRECWLRSEDYAKLIKFMDRYEENHSDIHAFKDAKFDQTRLQKFLR FT WLNSNPCLIPYRLQVFATAKVTFFQYLHDYSYIATFVFTYVFQALMLGSLFYNLRNESS FT ELYSRGSVLSNAIVFTAIQTMSEVDIIFLKKSLFKEHRVQSLYHPSAALMGSSLVEFPM FT RIVVVTMYDIIVYFLSDLKRNARSFFIFYLFTIVITFCMSAVFRFIALLSTTAEIAALI FT GGIGALVLIIFCGAVMPVQYIGWWFRWIAYANPVNYGYESIMLNEFDGREIPCSLMAPA FT PDTAPIENNFCLATAGRTGTSIVSGYQYLQVVYQYKADFLWRNCGIILGFAIFILASSL FT ILANFIRYDRESVHIPEFQKRKSYSQVASSFLIEPQDKPPSQTEPDNKKVDVSTTLSTN FT DNLVLCWRDLNFTVVTKTSKKQILTNVSGYLKKNTLTALLGENKSGKSVLLRILSQRGI FT AGSVEGEITLSGLKNPKNLRKRIGYVRKNPLFISEYTVRETLRLHAALRQSKQRSLSEQ FT YAYVEYVIDFLGLGEVADFIVGDMGKGLSLYHKRLLSIAVELSARPGSILLLDEPANGL FT DSQSAWMLVCILQKLARSGLSILCSVSQPSSRILELFDMMLILDLNGNTVYYDTMGRDL FT SKLVNYFKRIHGTNEHSKDTADFVLHCIQFLKQGPEFDYAGAWASTNTHKQIIEHVNFI FT MDNPELTDDDFPNETRFMTSFFFQIYKISMRNFVAYWRDSSLLRARVAFNIVAGLIIGF FT SFYKQGVGVEETQNKMFSAYMLTVASTSTMNGLQPKFIYFRSIYEQYEQNTAIYSRTAF FT IIAFFLVEAVINCCFATLFFFGWYYPSGFYEFNHNIPFYGGFAWLMLMIFTLYYTTLGI FT GIATISPSIGTASIISGTAFVFIQYFNGMIQLPGVIVGFWKWMDALSPYKYFLEGMIGG FT VLHDAPITCEKFEIHYVDPPPNYSCGEYFSSFLNSSGHGIVYNPEAYSSCQYCPYKNAD FT ELMVGFGYHYNHKWRNFCIMIGYTAFNLGAAIALYYIIHKTPWKRLAARFVPD" FT misc_feature complement(14916..15440) FT /note="Match to ABC_tran Score 73.30" FT CDS complement(18531..21440) FT /db_xref="GOA:Q9C0Y4" FT /db_xref="SWISS-PROT:Q9C0Y4" FT /label=SPAPB24D3.10c FT /note="pB24D3.C.cand.1 score = 71.24" FT /gene="SPAPB24D3.10c" FT /product="putative family 31 glycosyl hydrolase; FT glucosidase" FT /protein_id="CAC36906.1" FT /translation="MMISTAYQSLFLTALFSAISIAVGNVYQTFNVIGDRNVTIPTNGI FT PQRLSVYDPYRGVNCQGYQAVNISESQNGVTAYLALLGEPCYAYGTDYPLLFLNVTYEE FT ADRVHISIKDANNTQFQFTSRKDLWDAPLYSPSYNNTNLLYNFSYNANPFEFWVTRKSD FT GEVLFDTRGQKLVFEDQYIELTTNMVENYNLYGLAETIHGLRLGNNLTRTFWANDEPSP FT VDQNMYGSHPYYLEQRYKADGINSTLNETTYTSSSHGVLMLTANGMDVLLRQDYLQYRM FT IGGVIDLFVYSGSTESPKETVKQFVQSIGKPAMHQYWTLGYHSCRWGYTNITEIMDVRQ FT NYIDADIPVETFWSDIDYMEKYRDFTVDPVSYSKSDMQTFFSDLVSNHQHYVPIIDAAI FT YAANPYNHTDDSYYPYYAGVEKDIFLKNPNGSIYIGAVWPGFTAFPDFTNPDVVDYWKD FT CLINLTYAFGSNGTVPFSGIWTDMNEPSSFCVGSCGSAMIDLNPAEPLTGISKQYSIPE FT GFNVSNVTEYSSAYSASLSNYYATATSSVFQIVSPTATPLGLKPDYNIDWPPYAINNEQ FT GNHDIANHIVSPNATTHDGTQRYDIFNMYGYGETKVSYAALTQISPNERPFILSRSTFL FT GSGVYGAHWLGDNHSLWSNMFFSISGMIVFNMMGIPMVGADVCGFLGDSDEELCSRWMA FT MGAFSPFYRNHNNIYQISQEPYTWSSVAEASRRAMYIRYSLLPYWYTIMAKASQDGTPA FT LRALFVEFPNDPTLADVDRQFMVGDSLLVTPVLEPNVEYVQGVFPGDNSTVWYDWYNHT FT EIVRQYNENVTLYAPLEHINVAIRGGSVLPMQQPSLTTYESRQNPFNLLVALDRDGSAT FT GELYLDDGVSIELNATLSVSFTFSDGVLSAVPTGSYEVSQPLANVTILGLTESPSSITL FT NGQNVSSFQYSNDTEELLITGLQNITSSGAFANSWNLTL" FT misc_feature complement(18651..21038) FT /note="Match to Glyco_hydro_31 Score 1261.89" FT rRNA 27242..27431 FT /note="784 (+1) 22 210 SPRG5S yeast (s.pombe) 5s rrna gene, FT clone pym3" FT CDS 28263..29314 FT /db_xref="GOA:Q9C0Y3" FT /db_xref="SPTREMBL:Q9C0Y3" FT /label=SPAPB24D3.11 FT /partial FT /gene="SPAPB24D3.11" FT /gene="SPAPB1A11.01" FT /product="putative membrane transporter; similar to C. FT albicans fluconazole resistance protein" FT /protein_id="CAC36907.1" FT /translation="MSVSDKDFKDIELLPVKSIESKDSIDQCDPLTWPIRIRIINTIII FT SFMTMLCMYGSSVFMPSIPELCEKFGEPETLVVLGATLYVIGVMLGPLIFSPLSELYGR FT RPLNIFGYTLFALMQIPTALSVNLAMFVVFRFFSGFFGSVGLGIGAGSLSDMFSKRDRG FT KYIGIYFLGICLGPAIAPIASGFIAGSSISWRWEFWILLMLSGVSLLAGVVFLKETYAP FT VLKRKQAKKLLEKQENQKSVEVKISEITESSQQIDPDKSFAEVVHILVTTIRRPLHLLC FT TQPIMILISLIVGTVYGILYLLFTAFAEVWISQYHFTSGLSGLTYISLSIGQVFAVFVL FT LPLNQKYWLSA" FT misc_feature 29120..29314 FT /note="nominal overlap with SPAPB1A11 S. pombe chromosome FT 1" XX SQ Sequence 29314 BP; 9498 A; 5344 C; 5531 G; 8941 T; 0 other; gatcttaatc ggatgtattc tgttaacaga ttctttgtta aattaagaga cattggtgga 60 gaccttgctg aaaaacttgc atctgttact gaaaatttta tacatgctgc cgaaaattat 120 ttcgctgtac agccagcatt tatggctgat gcttttgatt ttgcgagctt tttgacgtga 180 gttagtcaaa agcgcttaaa catttttttg gaatatgggg taaatatctt cttcatcttt 240 aagtcctaat tgtatattat agtttaactc ggtgttgatt gctatatagt agaaattttt 300 aaaaaatatt ataactgggt tgaattttaa aaggtgaagc aatgttcttt taaaaactta 360 gctgttttat agcggactgc ttttgaattc agctacgctt gtttataata ttaccatatg 420 acagagatat atatatatat atagtttaat cgaggaaaat tggtacctaa gtctttcaca 480 tatttattca tcgattaatc aatatcataa taattattac acaaaactaa tatacaatat 540 gctaattata agacttgcca tcatcttctt tggacacatg atctgcctga aaatccacag 600 taacaccttc agtaacattc tcatcaactg ttttaacagg acctttgaaa aaagttttac 660 ctccgtattt tggtagataa taatatccta cgcagaaaaa gactgtgaac cccagcacta 720 caatggccca attcatttcc actttattcg gattttggta actagggaaa agaagcataa 780 gcgccatgaa ccataaccaa gccacggcta caattgaaat aggcttgcta aatttcccgc 840 aataaaactt tccagggttc agccgattaa acaacaaacg gcatactaaa ggtaaagaat 900 atgaaataaa aaatgcgatg atagctaaat taaagataga gctgatggct gtcacgttaa 960 ccaacatgag caagccaaca ataatggtat agagattgac aagaagaatc gcattgagtg 1020 gaatgccgcc aggagttagc ttacggaata tccaactacc aggaagaccc ttgtctctag 1080 cgaaagcaaa aatttctcta gaagaagcca ggcataacgc agagcaatta aaacaaagag 1140 ctattatcaa aacagctgac acgccaactg cacccctttt gccaagatta ttataaagca 1200 cctgagaaac tggttctccg tagggagtgt ttagaataga actaaagtcg tgacccattg 1260 tgcctgctat agtgatcata atgcaaaatc ccataaaaag agataccgta agacttgaaa 1320 taattgcaat gggtgctgct ttgctagcat ttttggcctc ttcaacaata gtagcacacg 1380 attcaaagcc tgacaaaacc caaacggggg ttgtgaagca aaggatgaag gaccaaccca 1440 tgttagtcca tccagaataa ttttcgaaat ttccaaaaat atagctccca gtgtttctag 1500 tctcggaagt tgatgatgct gctaaactga taataaatat aagaatcgtg catatttgaa 1560 acaccacatt aaaactgctg aaacgagcaa ggaactttgt tggaagaaca atcaaagctg 1620 aacaggcaaa acttaaagcg acatagatac cgtactcttc atatttagtc ggagcatacg 1680 agggattggc aacagacgct gttgcttgaa caagacccgc agcagcatag atagtagagg 1740 caaatcctgt agaatatgcg agtgcaagta catatcccag gaaccaactt aagaaggcac 1800 ggtactttgg aggagagaga taagccgtcc aaaaatataa actgccagaa gtgggcattg 1860 atgatgccaa ctcgctcaaa gcaaaagcaa ttggaagtaa acaagtagca cccacaaacc 1920 aagaccaaac catacctccg gcgccacaat tcatactaaa ggccatggag cccacgagag 1980 aaggacacag gcccatggat ccaaaggact gaccaaacac ggcgagtagg gaaaattctc 2040 gtttaaactc ttgcttataa ccaaggttca atagcatctt atcgtcttct gtaacggggg 2100 cagactcacc aacctctatg tccccaacag agatatcgtg aaattctttc ttcatcccaa 2160 ttgtttcatc catctttcct agacacaact aacgatatat aaaaccaaac aatacaaagt 2220 gcagaacacg aaagattccc cagttgaata cacacgaggc aataactcca attgaatacc 2280 aatattaaaa acaaaaattg gtcacagcaa aaggtagtga gaaggcagta agcagataaa 2340 tgggatagcg atattgagtc aaaatagcaa aaagccaaat gattaaactc ttgattaagt 2400 atacgatttc ctaaaaaatt tcctgagaca attgaacgta gaagcccgtt tttatattgc 2460 taattaagat gatgatcatc tttctaatgt actgcttaat ctattgatta agtaagttct 2520 atttaaattc tggataggat aagagatttc aataagctat tacccttttc atttatcttg 2580 tcgaggttca tctctatgaa ataagaaaca ataaggcttt agatttccgc caaacctatc 2640 gatagcttat tttcctaacc acccccctat gcttgcagta aaatttatcg gccatttttc 2700 tccatggact ccgttataca gtacttctgc aatacaggcg ccgatattcg ccataaaatg 2760 agttatacga ttagtagatt tttgatatga tgggcttgta ttagccctaa atttgaaagt 2820 atataaaggc cagtttcact gtcttagaac cgtagctaca agaaattatg aaaagtgttg 2880 aatggtttac atggggagtt tttctgctac tttctggctt tggagaagct gggaggatgg 2940 gcttgggctt tcaggagaag aatccagttt tcgtaaagga aaaacaatca ccattctatg 3000 ctgtacctag taactatgag gaagtagaat tctcaagtat agtcgaacct atgtattcag 3060 ggattgcgac gtttggtcgt ttggagaatg ttgaatgttt gagtaaaagg tcagaggact 3120 ttgatattgc ctttatagga atgcctttcg atacaggcac ttcttaccgc cctggtgctc 3180 gatttggtcc aagcagtttg cgtgaaggat ctcgacgcat aaatactaaa tacggtgcag 3240 tgaatgtacc tcttgaaatc aatcctttca aatcatgggc aaagcttgtg gattgtggag 3300 atattccagt caccacgtat gatattctta aagctatgga tcagttagaa agtgcatatt 3360 tccagctaat agctcgaaag ccctccagtt ttactgacca tgatggattt gcaaaaaatg 3420 atactgtgct tcctcgagtc ctttcactcg gtggtgacca taccattgtc cttcccatct 3480 tacgagcttt gcatcgtgtt tacggacaac ctatttcagt tattcatttc gatagccact 3540 tagacacgtg ggctcctgga ttgattggcg atggcgatga agcagatgga ataaaccatg 3600 gttcttattt ctactttgct agtcaagaag gtattatgag caaagatgcc aacattcatg 3660 ctggcattcg tactcctatc tctagtttct ctgactacga tgatgatgtt gattgtggtt 3720 tcaaaatcat tgaggctcgt gaaattgatg atttggggat tgatggtatc gtcaaaaaga 3780 ttcgtgacag agttggtgat aatttggtat atttatccat tgatattgat gtgcttgatc 3840 ctgcatttgc acccgctacg ggtactcctg aaactggcgg ttggtcatct agagaaatga 3900 gagcaatttt acgtggtttg caaggtctga aattcgtagg cgctgacctt gtcgaagtag 3960 ctcccgctta cgatgttgca gaaataacat ccttggctgg tgcgcaattg ttatttgaca 4020 ttgtatctat gatggtgaaa tatcctttgg taaaagaggc tgatttatct cgttacatgc 4080 caatacataa ataattgaaa taactggttt atttaatatt caatatttat atcgacatca 4140 tagatacaga tacagaaatg agcatgttca aaaaaaatca ttattcatta tattattaac 4200 atatcatacg caagtatatc gttagagaca gctgagcgtc atctatcttg tatcacataa 4260 agtaaaagac aaatgtagca gaaacgggtt ttcttaacca cccaagagtg ttttgtaaat 4320 atttgcaaat gaacccatta aaacatctca tctccctttt gttatttttg ccatcattca 4380 ccaaaaaatc acttctttta tataagcgta atgtgacgaa aatgcttcgt ctgagtggac 4440 gtagacattc tattcagaaa tgattgaaaa gatactataa attggtaaac caaaaataaa 4500 aagaagcgta cataaaatgt aaaagaccaa ccaggaataa acttatcgaa ttcaactttt 4560 tacttttaaa tatataatac atctgtcctt cagtgtttct tcggcctaac aggctttgta 4620 taatcggcaa gttttgacgt tttccagaga taccatgctg ctgcagtacg aaaaggtgca 4680 catatttcac tatgcttaag aacatacatc ttggttggaa tttttggtaa tcggtgtaga 4740 tatcggtatc cattacgaat actcaaatcg tcagctggca taacatcatc acgattcaac 4800 gaaaagatga gtaacatttc tactgtccat cttccgattc ctttaatctg agtaagtcgt 4860 tctatcaatt cttcatttga gagcctttca gcttcttctt tagtaggaat caaaccgctg 4920 attgttgcct cagcaatgct ttttaatgaa tcaattttac gagctgaaaa tccacaggca 4980 cgcattattt caaaatccat atcacgaatt tcctctggtg ttggaaattg gccattgtta 5040 gaaatacttt taaagcgatt gaaaattgcg ttagcagctt tactatgcaa ttgttgagat 5100 gctaccgcac gaattaattc ttcataaggc tcttttttct ccatacttcg attgggtcga 5160 taattaccaa cgagcttcac gagccgtttc caattctcat ccaatccaga aagatggatt 5220 tctgcttttg tgagtgaagt gactatctct tctttctctt caatgtccaa agtcataata 5280 gcaaagattc aattgatcaa aaatttatca ctcattatgt gcttttgact aaacggtaag 5340 ggttttcatt ccttaggaat tgcactgcaa ttcgttattt atgtaagcaa gtcctaagct 5400 aaaaaaaagg aatcttgaag caaattcaac attcttagat gtaatttgaa acttcaatta 5460 aattttcatc tggatcgcga aaataaatag agaggataac tccttcagct ccagcccttg 5520 taataggacc ttcttctatg agaacatttt gcttttttaa gtgagcaatg acttgctcta 5580 agggtgtttt agctattagg caaatatcat ttgacccagg agtcagtatg tgtgattttg 5640 ggtcaatctc attacccttt tgatgcaagt tgatttttta tgaccgaaac cgagtgcctt 5700 gcgattgttt ccaaatgcga taaccgacat tcctaatgtg cgctcataga actcacaggt 5760 ggcttctacg tcttggacag tgaaaacaat atggtggaaa cgatcaattt atataatatc 5820 tttttccatt agttagtatc aaagatcttt tatagatgta aaatgttgta aaggagagtc 5880 agaggaaact aaccacttcc gttaaacaag taacaactct tcgaccttag agtatatgac 5940 agattaaaga aatattgggc gttcaataag gcataaaatg gataaaacga tggaatagct 6000 ataaagaaag catagtgttt taagaattat tcatccacct tactaagctt actttctcta 6060 attagcattg acgttgaaca taaagaagct ttgcagttgt cttcataata caattgaagt 6120 aactatacgc cttaatttac aatgacagaa gtatggagat gaatattgtt atataatctt 6180 aacacgtata aaatggataa atgcgctatg aagggaatgg gataaacatt aagtcttaat 6240 ttgtaaaaca gtagattagt aactggaatt gttctcaata taccttttat agcatttcaa 6300 aagtaacttc aaagataaaa aatatcacaa aagttatcaa actccaactt tgaggaagct 6360 tttgatagct taagggtatg cttttgaatt taaaacatta cttttgttaa atctccattg 6420 cgagattttg tcgaatattt catccggatc acaattatct aaactgttct acgtgacttt 6480 tagcgctaaa gtcatattct atgtattacg aatctttatt gatcaatgaa gcttcttaaa 6540 gccgttataa gttgatttat caaccatttc aaagcttctg gtgaagattt tggcccgaca 6600 ttatgtgtag ctcccggtat gatgccgctt aaggaactat tagaagttgt aggacgaatt 6660 gattcgcgaa atcggttcag taattgtgct ttatcagttg atggcgagac gaactcgtcc 6720 ctttccgaca taagcagtat caactgacta tgtgctgtgg agccggagat ttctttgaga 6780 ttaccaaaag ttttagcgaa atcatcggcg ctcaggtcag aggagaaaaa gtcatcattt 6840 ccgcggacat ctgtcaagtc aatgcatcga tttgcagatg tcggaacttc accaaaaaaa 6900 ttctctacct tgcttctagg taaaacatca tttcctagtc ctttgtcaag atattctgct 6960 ttaacccagt caaccaattc ctttgttttt tctttcccgt taaattgata cgcggcttct 7020 ctatccgata ctggagcttg tgctattccg gcgattaagt agtttggaag aatggactgt 7080 gtaagatagt atagtacatt ctgcgatccc gtggaatgtc ccatcaaaac gattttgcga 7140 gtagaaaagt ccgcgcctcc aatgtgcaaa aaatagtcca ctgccttgtg taaatcctcg 7200 tcatctcgtt tcaaacttcc cgttccccat cctatatacg aggactgagt ttgaacctgt 7260 acaatactcc aaccaatttc atctaatgga ttgaccagtt cttgaacata tggtactgtc 7320 aaaagaccat cgccaagtcc cccgacaaat aacaataatg atcgagttac gttggatgta 7380 agtgtaacgt tactttttcc aactagctcg aaagcaacaa gcctttctgt gtactcatgg 7440 agaataccag gatgcgaggc tgacatcgtg caataaataa aagaatcaaa tttttagatg 7500 ttgaaagttg aataattttc gcctaacctt acaaagtaga tattcatacg atgctcaaat 7560 acgagatatg agcaaggatt atatcttatc cattatcagc aaaacaacaa ctaagctcac 7620 tattttgatc gcgtgcttta taatataatt acaatccggt ttacaatcaa gtttaagata 7680 tgattataga aatctcatat agaaggattg aattagtaaa tttaggtatt gaagcttgga 7740 gttgattgta caaaagttaa tcaattcaag agtttaaggc gttcgaaact atttgcttag 7800 tattttccaa aaattattgt ttatagatca ttcagctact ataaagtacg aattttgcaa 7860 ttccttcttt tgcttttgct ttatgtagct ttccataaac cactatggat ttcaaataat 7920 gatggtcgca gttggaacga attcacaaac ccagcttggt aaaatgatta atgagaaaga 7980 gatatatcgc tctaaatgaa agttggataa cattattact agcagaaaag tggatatgtg 8040 cgataataca agtttaaaga tgcatacaat ggcaattaac gatttgagtg gtgtcaattt 8100 tgatttgtat gatgtatcca atcgaaaaag attgagtaag ttatatcttg tactgaacat 8160 cataaaattg caattagacg aaaatacagt aaacgtttat ctactcacta caattactac 8220 tactgagaga atacattaca ataaaccttt tcacaacagt gaccacataa ctaaacaaaa 8280 gtgattttta ttttcacata gaataaatta tgtaagacga taaacgacta caattaacca 8340 ggagtttcaa gaccgtgttt gagataactt atctaaaggg attagctttt cgcagcaaat 8400 cgcattaaca ggagagtttc atacgtaaag acccgtcttt ttcgtcaatt aatagggatc 8460 aaaaaacgag agaatttaag caaagtattg aaggaacttg acaccgatgt ctccaacaac 8520 ttgggtctga gtgggcaaag taccgttggg gaaagagttc aaggtagtgt tcaaagcact 8580 tgcaaaggtg aaggcaggct caacgagagg gctgtaacca gaagtgaaag tagcgacaca 8640 ttgtccataa atatagaagg gaccatagtt ggggaaagcg gaaaggggag catacttcca 8700 gctctcgatg gtgctagcca acttgtagca gtcgctcttg gtttgagtgt caatgaaaag 8760 ggtggcatta gcagcaccgg tggtgttgct gctgatctcg ttgaggctat gagcaatata 8820 ggttccccat ccgagttcat caacagtcca gttctttccg aacaagctaa caatgctagt 8880 caagtcgtac tcgtagctgt atttggccca gagagccaat gtaccaacca aagcgtcagg 8940 aacgacctcc ttggtagggt taacatcatc gaaggcagtg aaggcagcag cgaattcgat 9000 caagtcaccc ttctccaaag cgctgacagc agtgcaccag tcacgagagg tacgattgtt 9060 aataccgtat tgagtatcga taatctcgac acctaaagcg gtgtcaaaga gttcattggc 9120 aatatcccag tggtgaatag gaccattaag acggaacttg agagcatcac gaaccttaga 9180 gaaagtaccc ctagtagtcc tgttgaaacg ggtgtcaggg gaaagagggc cactggtgta 9240 gcaagaagtg ttggtgtagc taacaaccaa ggtgttatca ggagtgggaa cacttgagtt 9300 agaagcgttg gcaccataag cggtggtgag ggaacccaag gagagggcac ccaacaaggt 9360 ccaaacgaat gacttcattg aattgattga aaaaaaaaaa aaagagagag agagaaagcg 9420 aaaattaaaa taataaaaat aaaaaactta ttatgtctag aaagaccgtt taactagtaa 9480 cgactgcgtt taatagggac ggatgttttt agccaccaaa gtgttagcaa aatcccttta 9540 ctttttgagc aatttcgaaa ttgcaatact tttccttgtc ctaattgaac aatgcaagca 9600 tcatgaccag ccttcctata tatatcgttt ccgcagaact tccggacttt tcacaatttg 9660 tgtatgattc ttccgtgatc cgcagccgac tattcgcatc agttctaaga acattgttgc 9720 tcagccgtcc acctatcttc catacgctag aaaaatagtg aaacttttgc aggcttagac 9780 atggggcaat ggccacattc catacgaaaa tagaatcatc tggttcttga actgcatatc 9840 cgtgagggcc aacttttggt atttttcaac acaggatgga ttggaagagg ctttgtgttt 9900 ccaggattta tttttaacag tattcatttt ttttcaattg atcgtttttt ctctcaaaag 9960 ccatgaactg ccggttaggc tagacaggcg actgcttatt ttaaatttag gttatcacat 10020 tttcctttag aaattctttt tatttattta ttttatttat tattattttt ttattttttt 10080 aacaataaat ctttgctatg aatcccagaa gatgaatttt gtataaagaa aaattgttta 10140 aataaaattt tggaattctt ttttgtatta ttagaaatta ttgttgtagt gttttttact 10200 ggaatttttt tttttttttt tttttttttt ttttaattgt taaatatttt tttcaccact 10260 ttttttttat atcatacaag gcaacttagg tgggaggttt ttaatggatt ttattttatt 10320 ttatatcatt gtatacttat ttattcttca gtatcatttt tcgcattaca gcaaaaacat 10380 agtaataagt tagttgtatt gtatatgtat atactttttg aaatataccc atattcaata 10440 tacaaactct ttaatatgat cgacgcttac atttttattt gcacctccta gcttgttgcc 10500 tctatattat tatttatata cccttttgtt aatacaatta ctagtaatga atgaattggt 10560 gaaattattt tactgtaatg tgtacaaggt atacggtgct atgtaaatat acaatgattt 10620 tgtaaaacta tggggtttat ttccatacat atggtttcat gatatcttac aaaaaaacat 10680 atcgactcca tatacttact tcatgttttt tgggtcactg ttttgattac tttatttacg 10740 atttttgcaa acccatttct aattcatcct tgcttggaaa accaacctgt atactgcacc 10800 atcagtaaac tgtactatca tgaatagtag cgtaatcgaa catatatatt accacatata 10860 attcgtcagt cctggataca acggcccgct atgggtaaag cctaaaaacg ccccctttct 10920 cgagaacacc ctagaaccac agttgccgaa cgtcctatac tgtagtaaaa tttaatagcg 10980 gcaacctttt tttacacact gtgttagaat gcagaatgtt tatttaaaaa atttaataca 11040 actggctact atatataaat agggaattgt tcagaaaata atttactttc agtaattttt 11100 ttagcagagg acaagatata tcgaggtaat aaattgtaat ttgatatatg tttgcttaac 11160 actgttagac aaatgtagaa tttacacgcg gttcgcataa taagtatatt gaaaatggat 11220 ttaattacct tatctttttt tttaaaaaaa aaaaaaaaag atgtgctaaa tagactcgat 11280 gccgaatccc aacatttttg gtgaatttat ttacagtcgt tgaattgtaa atacaaagca 11340 aaataattta atgagccaaa tgcacattta tatatgataa agagagtatt aaatacttaa 11400 taaattttta aatgaaactg aataactaat taacggaaaa caaggatgaa gcatgcaatt 11460 gaatataaac aaatactaat tacttcttaa agtagcttct tcaacttgat tttcaatttc 11520 agtcttgtta acttacaatt tttaatagct cataaatttt atgcaacatt tgtattgaga 11580 aacgatgtaa tcaatagcac aaaaaaataa aactataaag ccctagtcag ggtctaattt 11640 tcatgtcttt ttactcatct gcaatcttca cgatggtctt acccgagttc tttccttgaa 11700 gcatgccaat aaatgcctcc ggcgcagact caagaccatc ataaacatcg cacttgtact 11760 ttatttttcc ttcagcaatc aacttgggca tttcctcaaa gtactgctcc tggtattgtg 11820 gcaagatatt agcgacaatg aagccctgta ttgtgagact tttgacaagt accataccca 11880 aattcttcac cctataagga ttaggattgt tgtattgact aatggcacca caaaaaatga 11940 tccggccctg taaattcata ttctcgagta ctgcatccat tgtttcacct ccaacattct 12000 caaagtagat atctatacct ttaggacaca aacgtggtag tgctttaaat ggactctctt 12060 tcttgtaatt gaatacactg tcataacccg agtctaagca tattttgaac ttctcgtcac 12120 tacctacgct gcccactaca tgcaatccca tagctttagc caattgtcct gccatctgcc 12180 ctactgctcc tgaagccgca gatatgtaaa tagtctcacc agcctttggt ttgccaatat 12240 gctttaaacc acaataggcc gtctgactgg gcataccgag tgatccgaca aagtcaatca 12300 aagggagttt atatggattg ttgatgggtt gaaggaaacc aagtgcttgt ttactcacaa 12360 acgtatattc ctcccatcca ctaacaaaaa caacatccat tcctggcttg tactggtcga 12420 gtgtcgattt gactactttg gcgactgtag agttataaaa cggttttccc aattccaaag 12480 gcggaatata cgatgcatgc tttggtgatt gcatacgcat acgaaggtaa ggatcaacag 12540 aggtataaat gttctttaaa agaacaggcg tttcttcgtc aacttgcgca ttctccaaat 12600 cgaattccct tttttcaaaa gctaagtgtt ctcctataac aggatatcca gctgtagaat 12660 caagatattt tttaataatt acagcgttgt ttgataccat cttcgctaag ttaggacaat 12720 gttaaatcta tagcgcaaac aaaaataagt gatttgggcc agaattgagt gagttacaat 12780 ttatagtctt ctgctgctta tgtaagatga gtatttgatc atcgtgacag tttgtgaatg 12840 ctcggatttg tgagatctac ggaattattg gcgatatcca acgctttaaa atttaaaaca 12900 tattttacaa gtaaatataa agaatgtttt gaagtgcgaa attgagattt aaatgaatgc 12960 tgttaactta taattcaccc aacgctgagt gttgttcagg ttcatttttt actcgttact 13020 tacattttgt gtaataagtc aaggaacaac gatattccac gtgttgatag gtatttgtta 13080 ggtatccttt tggaaacaat agttagtcct tactaaaata agctaatata tcaactcgcc 13140 aacttcgatt ttcctttcat aaaaactgta acgaattttt gtataggcat cagcacttaa 13200 atatcctcta gcggcatcta tatggcaata gcaatagcat ctaccacact actcataaaa 13260 tcttgaattg taattacgct gtgttacaga cgtactacct cgtatcatct tagctttaca 13320 gttttacttt gcgatctact ctaccattac tgatgagccc tgtatcatag acaaatacaa 13380 tacccgtttg cagcttgaaa acaaataaat aacaaaacta attttattaa aggtaaacaa 13440 aatgactatt atagacctaa aaaatccttt ataggtttct cgtctagaat atagataaat 13500 tggaatccca gaaccccggg tatcgaataa ataaaaaaaa aaaacgatgt tggctttaaa 13560 atccgtgtaa tctttttctc taaagatgtt acgcaaaacc aacagtaaga gatctaatct 13620 ggaacaaaac gagcagccaa ccttttccaa ggcgttttgt gtatgatata gtaaagagca 13680 attgcagctc caagattaaa agctgtgtag ccgatcataa tgcaaaaatt tcgccattta 13740 tggttgtagt ggtagccaaa gcccaccatg agttcgtccg catttttata aggacagtac 13800 tggcaactag aataagcttc tggattatat acaatcccat ggccactaga atttaaaaag 13860 ctactgaaat attctccaca gctataattc ggtgggggat caacgtagtg aatttcaaac 13920 ttctcacaag tgattggagc gtcatgtagc actcctccta tcatgccttc taagaaatac 13980 ttgtagggac taagtgcatc catccacttc cagaaaccta caataacacc cggcagttga 14040 atcataccat tgaaatactg aataaacacg aaagcagtac cactaatgat agaagcagta 14100 ccgatactag gtgaaatcgt agctataccg attccaagag tcgtatagta taatgtaaat 14160 atcattaaca taagccatgc aaatccacca tagaaaggaa tgttatggtt gaactcgtag 14220 aaaccactag gatagtacca tccaaaaaag aaaagggtag caaaacagca attaattacg 14280 gcttccacca gaaagaaagc gattataaat gccgttcgag aataaatagc agtgttctgc 14340 tcatattgct cataaatgct tctaaaatat ataaatttgg gttgtaaacc attcatcgtc 14400 gatgtggatg ctaccgtgag catatatgct gagaacatct tattctgcgt ttcttcaaca 14460 ccaactcctt gtttatagaa tgaaaaccca ataataagac cagcaacgat attaaatgcg 14520 accctagctc ttaaaagaga actatctcgc caatacgcta caaaatttct catggagatc 14580 ttgtatattt ggaaaaagaa actagtcata aacctcgttt catttggaaa atcatcatct 14640 gttaattctg ggttgtccat gatgaaattg acatgctcaa ttatctgttt gtgagtattc 14700 gtcgaagccc atgcacccgc ataatcaaac tcaggacctt gtttcaagaa ttgaatgcaa 14760 tgcaaaacaa aatcagcagt atccttactg tgttcattgg ttccatgaat acgtttgaag 14820 taatttacaa gtttcgacaa atctcttccc atagtatcgt aatataccgt atttccattg 14880 agatcgagga taagcatcat atcaaatagc tccaaaattc tagaacttgg ttgactaaca 14940 gagcataaaa tagataaacc tgatctggcc aacttttgca aaatgcacac caacatccaa 15000 gcagactgac tgtcgagacc atttgcaggt tcatctagca gtaagattga acctggtcta 15060 gctgaaagtt caactgcgat actaagtaac cttttgtgat ataaactcaa acctttaccc 15120 atatcaccca caataaaatc ggcaacttct cccaatccaa gaaagtcaat aacgtattca 15180 acgtatgcat attgctctga aaggctcctt tgcttcgatt gtcgaagggc agcatgcaaa 15240 cgaagagttt ctcgcacggt atactcagag atgaataacg gattcttccg aacatatcca 15300 attcgctttc taaggttctt tggatttttt aaaccactca aagttatttc gccttcaacg 15360 gatccagcta tgcctctttg ggatagaata cgaagtaaca cagatttacc agatttattc 15420 tcaccaagta aagctgttaa agtgtttttc ttgagatatc cactgacatt tgttaagatt 15480 tgcttcttag aagtcttcgt taccacggta aagtttaagt ctcgccaaca taataccaga 15540 ttatcattag tagaaagagt cgttgaaacg tcgacttttt tattgtctgg ctctgtttga 15600 ctaggtggct tatcttgcgg ttcaattaga aaagacgaag caacttgaga ataagatttc 15660 cgcttttgaa attcaggaat atgaacagat tctctgtcat acctaataaa gttagctaga 15720 atcaaactgc tagccagaat gaaaatagca aacccaagga tgataccaca atttctccat 15780 aggaaatcgg ctttatactg ataaacaacc tgcaagtatt ggtagcccga gacaatactc 15840 gtaccagttc ggccagccgt ggcaagacaa aaattatttt ctattggagc agtatccggt 15900 gcaggggcca taagagaaca gggaatctct ctaccgtcaa attcgttcaa cataattgat 15960 tcatatccat aatttactgg gttagcatag gcgatccatc taaaccacca accaatatat 16020 tgaacaggca taacagcccc acaaaaaata ataaggacca aagcgccaat accaccgatt 16080 aaagcagcaa tttcggcagt cgtggatagt agagcaataa accggaacac agcagacata 16140 cagaacgtaa tcacaatcgt aaaaagatag aatataaaga aagatctagc atttctctta 16200 aggtcggata aaaaatacac aataatgtcg tacatggtga caaccacaat acgcatagga 16260 aactcaacga gactggaacc catcaatgct gcagacggat gatataaaga ttggacacga 16320 tgctccttaa acagcgattt tttcaaaaaa atgatgtcca cttcagacat tgtctgaatg 16380 gctgtaaaaa caatagcatt cgacaacaca ctgccgcgtg agtacaattc acttgactcg 16440 tttcttaaat tataaaaaag agagccaagc ataagtgcct gaaaaacata agtgaaaacg 16500 aaagtagcaa tatacgagta atcatgaagg tattgaaaaa aagtcacctt agcggtagca 16560 aatacctgaa gtctataggg aataaggcat ggattggaat taagccatct taagaatttt 16620 tgtaaacgtg tttgatcaaa tttggcatct ttaaaggcgt ggatatcact atgattttcc 16680 tcatatcgat ccataaactt gattagtttg gcataatctt cgcttcgaag ccagcattct 16740 ctaaattcgg caggagtcga aggaataaat ccctgatgct ttttatttat aatacgcatt 16800 tctgggtatg tcaaagaggt gacaaattca acagtagtgc tatgttttgc tggaatgaaa 16860 ccaagatcca agaaatatgg ctttaaacgg ctcgtaggcc catagaatat ttgttcacct 16920 tcatacatca aagtgaccat gtcgaacata tgaaaaattc tatcagaagc ttgactaaca 16980 atggctacca gtgtagtacc tagcttatgt gaaagcactt tgatacgcga aaggatgtca 17040 ataacggata tggagtcaaa atcacgcatg ttgttatccc agcattgtat taggggtcgt 17100 gcacacatgg tctgagcaac atcgacctta atctgatcgc cggagttaaa gacgcgaaga 17160 attcgatggt tgtaaaagtc tcccaaatca aatgcatcgc gaatgatttc gcaaatgcga 17220 cggatataat gacttctcgg gtgatcatat tttgatgcag gaagtcgaca ggagcaaaca 17280 aactctaata aacgtcggac cgtgatagta gctactttgg aatgaccttc accacaataa 17340 ctcaagtcag ctttaaattg agaatgcgct attttgtaat ctaaaccgtc gtaatgaagc 17400 gatccattca acctctcatt ttcttctaca ataccacaca aagcctttag cagtgtggac 17460 ccaccggatc cttcatggcc caacaccagt aatgatgaac cgggctgcag ataaccatca 17520 aatcctttaa ccaaagggat gatgtcgcgt ttaggacccg ttcgaaatat aatattgatg 17580 gggtgtagta attgcgcaaa gaatgatcga atttgaaatt tcgggttgaa ggcaccttcg 17640 acggtgaaat ttcgcatgca aaatcctgat gtccgacctg tcaagtgcag ttcattgagg 17700 acttctaagt attcttcaac tttctgctca aacttatcag gacacttggt gtttttgctg 17760 ttaggatcat ccaaatcacc tttccctttt tcttgttcac tcatgccaca gtgcaaacaa 17820 ttgtatgtgt ttcaaaagag tgtcaaacct ttaaatcctt ctaattacaa ccttcaatgg 17880 tagccataag tagtatgaag aaagcaaaaa ttttttaaag acaatcgatc gtgacgttgc 17940 taactcgggt ttgcccttat actatttgtt gcgtagatcg tagtttgtca cctggttata 18000 tcaatacagc aatttcttgc attcgataat tggataagct gaaggaatcc attatacaag 18060 ttccttgttt acaagaaaaa ttgtgaagat actttagttt taccttactt caaggattcc 18120 tgattaatac ctttgctttt acatcttcaa gctttcgcta gtaaatatgg tttgcaccac 18180 atcatactac ttttaagata attagcgaat tcggacgaca aaaaatttta tcgctataca 18240 gatttaacgg cgacgaagca ggtttaatag tatgtgtaaa tttgtttaat gcgtttgaaa 18300 gatcaacggt aaattttacg ttaaatacat aaacatccat ctttacgcag cggtgctatc 18360 tgatgggttg tgtagaaaaa gtagtttatt tattgaattg actaacaatg actgtaagtt 18420 tattccatat actacaagca tctcgagagt tgctagatgc aacaaactag actgttaatt 18480 agtgctcggt tcctggattg ccggtgaaaa atcgggtgaa gcgagagcga ctacaaagta 18540 agattccagc tgttggcaaa tgcaccagag gaagtaatgt tctgtagacc ggtaattagc 18600 aattcctcag tatcgttaga gtactggaag gaggagacgt tttgtccatt caaggtgatt 18660 gaactagggg attcagtgag accaaggatc gttacgttgg ccaagggttg gctaacttcg 18720 tagctgccag ttggaacggc actcaaaaca ccatcactaa atgtgaagct aacggaaagt 18780 gtagcgttta gctcaatgga aacaccatca tcaaggtaaa gctcaccagt agcagaacca 18840 tctctatcca aagcgacgag gaggttgaat ggattttgac gactttcata agtagtgagc 18900 gaaggttgtt gcatgggaag aacactacca ccacgaatag cgacattgat gtgttccaaa 18960 ggagcgtaca gagtaacatt ttcgttgtat tgacgaacaa tttcagtgtg gttgtaccag 19020 tcataccata cagtgctgtt gtcaccaggg aaaacacctt gaacgtattc aacattaggc 19080 tccaagacag gtgtcaccaa tagagagtcg cctaccatga attgacggtc aacgtctgct 19140 agagtaggat cgttggggaa ttcaacgaac aaagcacgta gggcaggtgt gccatcttgg 19200 gatgccttag ccatgatagt ataccagtaa gggagtaaag aataacgaat gtacatagca 19260 cgacgtgagg cctcagcaac agaagaccat gtgtagggct cttgtgagat ttggtaaatg 19320 ttgttatgat ttctatagaa tggcgaaaaa gcacccatag ccatccaacg agagcaaagt 19380 tcttcatctg aatcaccaag gaaaccacaa acatcagctc ctaccattgg aatacccatc 19440 atgttaaaaa cgatcattcc agaaatggag aagaacatgt tagaccatag agaatgatta 19500 tcacccaacc aatgtgcacc atagactcca gatcccaaga aggtagaacg actcaagata 19560 aagggtcgtt cattaggaga aatttgggtt agagctgcgt atgagacctt tgtctcacca 19620 taaccataca tgttgaaaat atcgtaacgt tgggttccat catgagtggt cgcattgggg 19680 cttacaatgt gattggcaat atcatgattt ccttgttcat tgttaatagc ataagggggc 19740 cagtcaatgt tgtaatctgg cttcaaacct aatggagtag cagttggtga aacaatttgg 19800 aacaccgatg atgttgcagt ggcatagtag ttgctaagtg aagcactgta agcagaacta 19860 tactcagtca cattggaaac gttaaatcct tctgggatgg aatactgctt tgaaattccg 19920 gtcaagggct ctgcagggtt taagtcaatc atagcactcc cacaagagcc cacgcagaac 19980 gaagagggtt cgttcatatc agtccaaatt ccactgaatg gaacagtacc attcgatcca 20040 aaagcataag taaggttgat aagacagtct ttccaatagt caaccacatc gggattggtg 20100 aaatcaggga aagcagtgaa tcctggccaa accgcaccaa tgtagatact tccattagga 20160 ttttttaaga aaatgtcctt ttcaacgcct gcatagtatg gataataaga gtcgtcagtg 20220 tgattgtagg ggtttgcggc ataaatcgca gcatcaatga ttggaacgta atgctgatga 20280 ttgcttacca aatcactgaa aaatgtttgc atatctgact ttgaataaga aacagggtca 20340 acggtaaaat ctctatattt ctccatgtaa tcaatatcag accaaaaggt ttccactgga 20400 atgtctgcat caatgtaatt ttgacgaacg tccatgattt ctgtgatatt tgtgtaaccc 20460 caacgacatg agtggtaacc caatgtccaa tattgatgca tagcaggctt tccaatggat 20520 tgaacgaatt gcttgacagt ctccttggga ctctcagtgc taccactgta tacaaaaagg 20580 tcgataacac caccgatcat tcgatactga agataatctt ggcgcaaaag aacatccatt 20640 ccattagctg taagcataag aacaccatga gaagaagaag tataagtggt ttcgttcaaa 20700 gttgaattta taccatccgc cttgtatctt tgttctaaat agtatggatg acttccgtac 20760 atgttttggt ccacggggct aggttcatca ttagcccaaa aggtacgggt taagttattt 20820 cccagacgta aaccatggat ggtttcagcg agaccataaa gattataatt ttcaaccata 20880 ttagtagtta actcaatata ctgatcttcg aaaaccaatt tctgtccgcg tgtatcaaat 20940 aaaacttcac catcgctctt acgtgtaacc caaaattcga aaggattggc attgtacgaa 21000 aagttgtaca gaaggtttgt gttattgtaa gaaggtgaat ataagggagc atcccaaaga 21060 tctttcctac tggtaaattg gaattgagtg ttattagcgt ctttgattga tatatgaact 21120 cggtcggctt cctcatatgt gacgttgagg aacaacaatg ggtaatcagt accataggca 21180 tagcaaggct cgccgagtag tgcgagatag gcagtaacgc cattttgtga ctcagatatg 21240 ttaacagctt gatatccttg acaatttaca ccgcgatatg ggtcatatac ggataagcgt 21300 tgagggatac cattggtagg gatagtgaca ttgcgatcac caatgacatt gaaagtttgg 21360 tagacgttac cgacagcaat cgagattgct gaaaacagag cagttaaaaa tagagattgg 21420 taggcagtag aaatcatcat cgttaaaaaa aaacaaaaaa gagatcaaaa agttttaaga 21480 aaaatcaaag taccaactaa aaagaatcgt agagaaaaag aatggaaaag attaaccaaa 21540 aaggcaattt ggcaatagaa gggcggttta aagaggcgaa atcgtaaaga aaaggagggt 21600 tttaagagac agacaaaaaa ttaagcaaga actacaacaa tagaattgta gactttcttg 21660 tccaagtttt tttttcaata taaataaaaa gttatatata tatatgtgtg tgtgtatgta 21720 tatatatagt aagttaggaa agaaaagctc tttcacgaaa agcttgaaag ggtttgttta 21780 aacgcgcgtt ttaaaaagga gcgaaaccca aaaaaaggta agaggtagga ttaaccaatc 21840 aagtccaaaa cgacgtaatt aagagcggct aagcgaacct tataaaagtg ggggagaaac 21900 ttttgtagct tgtgttactt agcacttttt gcaaaacgaa gtgtatgttc gcttgaaggt 21960 gcaaagaacg aggaggaagc gaaaagcctt gattaattga tttgatgggt aaagcctttg 22020 aaagccaagt cgaatcgaat caatctaaaa gcaaaaaaaa agataatcaa acccaacgtt 22080 tagtaacttt tttgtaaaaa aagtagggcg ataggttgga aaatggatcg attttctcgt 22140 ggggatggaa tcaatcgact cgtttctttt gcaatgtggg gagacttact aaggcggatg 22200 tggggggagg acaaaaaaac aagtagcaaa gaatcaaaac ttaacaaaat aaattaaagg 22260 tgtggaaggt ttgagagcac ttctgttcta gtggaacaga tattgcttgg ttttaataaa 22320 gggagtggtg taatcacagg agaaaacagt aggaaaacta ttgagttata cccaactgtg 22380 ttaccaatag agtacagaca ctggaagatt tcggatcaaa aaagttgatg aaaacttaga 22440 accaaaaagg cgcgaggtat tcacttgact tatgaataaa cgaatcgatt aaaaaaagtg 22500 cgagcgaacg ctttctttta taactacaaa atttcattct tcacaaatat cactcttacc 22560 cttcatgttg tcattttcga cgtaagggtg gggaaagcga aattcgggtc agatcaaaat 22620 ctcccatcat tcgataattg ccgttaaggt tttatcaaat tccgccaacc gaaatgatgc 22680 aagttcacac tgtggggaag aatagtgtca agggaaaaac aagtgtcaga tgtttatatg 22740 atatgataac tcttagacaa atcttaacct ttagcatcca ccactaacat ggctatttta 22800 agcgtccaaa aacattgatc atctgaaccc cggactttgc gctttcctac gccgtaaaaa 22860 attgattcag gatttcggag tttaagtgtg ctttaggttt agatagccca acaattatta 22920 ttgtttgcat ttctcaggtt aggtaaagct tcttttcaca aagcaataac ggctgtgtaa 22980 tgaaattgaa agatgaaaaa taacgatgga aacggatgca ttgcaatatt aaaattagag 23040 gagctgtaag aaagaaacga acaaaaatac ccaggctaaa aatatgtcga ggcaagtaaa 23100 tagaacggtt cttgtttcat agtgtagtag tagatggcat agacgacgaa taaaaaacca 23160 tatgtacgtt gtataacaag ttaattctta tcatttgttc aattacgagt ttctttgttc 23220 atgtaactat gtagatacat tatctcatca tgcaaaagtg ctttttcgac tccttttttt 23280 ttgttttatt ttttcaacaa agaaaggccc aaaataaaac acacacatac acaccacttt 23340 gtagcggtga gcgcacatca ggtgccataa tgtctacccc attttcgcct ggttaaaaaa 23400 cgtaagctct cctgacccat taactaatga tccaaacgga ttatttggtc gcttgcgtga 23460 cttacgtgga ccattctttt cgttgtaggg aattttgcga gtagtaagca aatatgtgct 23520 ataggcagta gcgatcgaat gtggtgtgcg aaggagtgcg aaatggagaa tggacaagac 23580 aagaggagaa tatgcaagga aaagaattct ttggggtgga aggagcaaaa aaaaaggaaa 23640 tcgaaatcgg aacggtattg agttacttgg ataatgaaag attcttgatt aattgacgga 23700 tagcgatcca aacgctaatc ccaacatatt cacccttgtc gcctatacta aaagttcgga 23760 tgtaattctc acctgaggga tgaaatgttc actaaacgac tcgggtgtaa attcatgaaa 23820 catccgcttg gaaccacaat tctccagttt gaaatgatca gcttgcggca accatagatg 23880 aaaagacact agaaaaaaca tatgtctagt caattatgcc tgtggcagaa aattggtttg 23940 ccctgatgta ctttgtttcg gcagtcgagg ggaatcatga tggatggagg ggcgatgtca 24000 ggttactaaa aggaaaccat taattttaaa aaaggtattc aactatttcg aaaaggaagt 24060 ggttccgctg ttgttgtgtg ttgagaagag gaattgatgt tgattgttcc aattcgagca 24120 gaaaagaatg ggcaaattaa ctttgtacca taaatgctta aaccttacaa gctctttttt 24180 taataccgtt attttgtctt gggtatacaa atcaaatgaa caataatctc taccacctag 24240 caaaatgtag acgaagcgaa ttgagaatgc attctctacc tgctggaagc gaaatagtct 24300 gtttcccaac ttacagcgaa gttgccgtta ctttcactaa aatcatacag tgaagaattc 24360 cgtaacaagt ttaactgcgt taaaacaatt tatcaagagg taacgcatct cgcatttctg 24420 tacagctaaa aataggcttg tcttgaactt gaaaagtgtg atagagtttg ttagactctg 24480 ttagaccaat agaaataaat ttgtcaactt ccgttcgcag tctatcagat tacatagtaa 24540 tttgttaaga cttgttagat tcctttaaac ctaaagacac cgcggttatc tgttagattt 24600 cggtagactc ctttaaatcc tgtaaggctg cgttaatgtc tgttatacgt ctgtagaatt 24660 cctttaactc atataaagcg actttattct ctgctatccc ttgttagact cccttaaact 24720 ttctagtgca ccgttatttt ctcttattgt tagactctct tacaccttat gaattcgtgt 24780 accgcccgtc tcggtgaaca attttacgag ttgctgcgta atcggatcgt gttgagaata 24840 ctgtggatat tgggatattg gtctgggaaa tgaatggatt gatcgtcgtt ggccagacaa 24900 acatacaaga cgattccttt ttcaaaagag caatttgcaa tctttctatt ttcatgtggc 24960 aaagattgtt tgctcaaacc actattgata gtccagagtg acatctattc aagattgatc 25020 atctctattc accattgctt cattactcca tctttttggc ttgctaagga tttgctctca 25080 acggcaacgc agtaccaatc aatcaaaata tacctttgca aatgctaaaa ttctaaaaaa 25140 aaaaaaaaag aaaaaaaaat gtcgatagaa tagacagcat gtcatgttta tgagtgttat 25200 ggtttgctac tcttggtcga attttgacat cttaaattaa taaaaaaaac tcttggcatt 25260 tatcgcacca gcgcttcatc gataccgtca ctgaaccaat ccttttcaag gggtcactca 25320 ttctaaatac attctcttac aagtgtaata acacataagc taatcatgtg tcgtttattt 25380 taaactttct tgcagcttct gcttcactgt ttcgatcact tggcgcaatg cttatggagg 25440 taatgtatta aattgcttct tttcaccgag gcaagacgat ttgcaaaagt gttggcatat 25500 gcagacgtat acttgtattg tctgtagctt taagagagat ttgtgttcta gaatttttct 25560 aacacactac tgcaatggcg acaaggtaca tagataatgt gttgtgtatt ggtagtagaa 25620 cgaaattgtg ttgaatttat ttttgagaaa ataatattat attatatctt cgtttttccg 25680 aattcggttc ccttctaaca atttctcgct tatgattagt ccttgatatt caggaaatat 25740 ttaaaaaaaa aatatcggat taatcaatat atcttcaaac aattggtggt gaataagttc 25800 gtaactcttt acatcatgac tccagctgga tatgcaggct ttggataatg aacgtaaact 25860 taatagcgaa tggcatagca cttttgtctt agaggttatg gaagggtgac aaaattcaca 25920 tgcgtcttga ccgaaccatt ctgtaaaaat agtatatata gtagtgggtc aagcgcattt 25980 ttatttcatg aacttaagcg tatttgtcta tcattgatac attatctgga gtattctacg 26040 ctaaggaaaa cacatattta aaaaagcggt ttagacactt attcgtatat caatatgact 26100 actggaaaac ctcaatcttt cgaaaaaatg cgcactccat ttcctggaag atctaaagcc 26160 aaagggccgc agagcgatat tatcccaagt gctcccccaa atactcctgt aacagagcat 26220 taaaaggaag cgctagacga cttgactggt ctttacttaa ttcgatttgg gaattattaa 26280 ggacggctga ttcagcgcaa cgatatactg aattggaaac aattgtgttt tgccaaacgc 26340 gttaccaatc aatctctgga ggtttgattt gaacgaaacc caattcttct ttatttgttt 26400 taaacgattt tacgaattca acattttctt cctttcaaaa ttttgttcta gaatttttct 26460 tcatgtgaaa aatatgtttt tttattatta ctactattaa ttaaatgaca catgatagat 26520 gcttgttaat aagccacaaa tgtgccacga attttattta tttctttctt ttcttataca 26580 gtcaatattc aatacaggct tgtttggact gccgtatata aatagcgaac tggtttcctg 26640 gtagctaaag agtgtattag atatcgaatg aattgccttg agtaaagaga gtttcacttt 26700 tcaattcaat gtaaagcaga gcaactccga aaatgaatat tacgtattag agttttagcg 26760 cactaaatac aaaaacatag tacacttaag gacagtaact gttttagacg aaagggtcga 26820 acttgtcgac accgtgtaat ataaaagtgc tttatggaag gatattttga tgcaaaaatt 26880 tgagttgagc agttgctgaa ggattacaga ttttcatgaa actaacaggt taaccctttg 26940 cctttagacg ataataaata taatcctata ttgtaaaaat gttattctat tctactaaag 27000 ggttttctat ataaaaagac gttttatatt gtaaaagtgt tataaaagat atcgactgaa 27060 taccaattat acttttaatg gcatggaaat ggaagcgtct aaaaatttaa aaaatatatg 27120 ttaacacttt tcgataaatc caagcgtttc ggttattaaa cagctcacat aaaatttcct 27180 ttttgtgcta gttcaaagcg ttgtctcttt ttacccataa ggaaatgtga ttttttttac 27240 caataaattc tacttatgaa taaatcaaat gtctacggcc atacctaggc gaaaacacca 27300 gttcccgtcc gatcactgca gttaagcgtc tgagggcctc gttagtacta tggttggaga 27360 caacatggga atccggggtg ctgtaggctt ccttttattc tttttttcta ttttttatta 27420 atttcatttt cataaaaaaa aatcttgctt tgtctgatat tttttacggt ccaaattcga 27480 ctattctttg tgaataaaga aatgatgtga aatattcaat tatggtttcc acaatgtcct 27540 tgattgacca ctaaggcgct aagcgaaaaa agtctgatgc gttttcgata tgattgcctt 27600 tgattatatc ctaggccgac aatcgctcgg tttttatttt attttaaaaa aaaaataaaa 27660 aacttagaac cacgtggctt gtggaatctt tcgctttttt ttttttattt ttttttttta 27720 agaataattg atgcattaat ttttcatttg agtttcaatg tgtttgctct agcaacttga 27780 ttatttaaat gctctccatc acacagtcaa tatcacatct tgtacaaagg gaaaattcgt 27840 ttacgaccgg aaaagaattt tctctttcct atcatgttta tagccagcgt atttaagact 27900 gactttgctt gtttacacat gtgtcactat gaactaaagt tgcctaccca acagactgca 27960 taatggaatt gaatagaaat tttcattttg agttcatcga acgttttgtt catgatcata 28020 cgctcgtgta acctaacaat tgatctaata gtaatcgact tcgtatcgct cgcttcaccg 28080 tatcgctaaa ctccgaggat ataagtgcaa actttgaagc tagctcctgc actagcactg 28140 ttttaactgc atgcttatcg ccgaggaaag ttcataacgc cgaagcaagt aattgcaaat 28200 gatatatata ttctcatcat tctcaatctt cttcatcttg tttcagaaat taaacaatta 28260 taatgtctgt ttctgacaag gatttcaaag atatagagct tttgccggtg aagtcaattg 28320 aatccaagga ttcaattgac caatgcgatc ctctcacctg gcctataagg attagaataa 28380 taaatacgat aattatttct ttcatgacta tgctatgtat gtatggatcc agcgttttta 28440 tgccaagcat tcccgagctg tgtgagaaat tcggtgaacc ggaaacattg gtcgttttag 28500 gtgcgactct ttatgtgatc ggcgtaatgc taggcccttt gatattcagt cctctcagtg 28560 aattatatgg aagaaggcct ctcaacatat ttggctatac tcttttcgcg ctgatgcaaa 28620 tacccacggc tttgtcggtg aaccttgcaa tgttcgtggt ctttcggttt ttcagtggat 28680 tttttggatc agtaggtttg ggtattggag ctggtagctt aagcgacatg tttagcaaaa 28740 gagacagagg aaaatatatt ggaatttact ttctcgggat ttgtttggga cccgcaattg 28800 cccctatagc atcaggcttt atcgccggga gctccatctc ttggagatgg gagttttgga 28860 ttctgttaat gctttcagga gtaagtcttt tagctggtgt tgtgttttta aaagagactt 28920 atgctcctgt actgaaaagg aaacaagcaa agaaacttct tgaaaaacag gaaaatcaga 28980 aatcagtcga agtcaagatc tcagaaatta cggaatcctc acaacaaatt gaccccgaca 29040 aaagcttcgc tgaagtagtg catattctcg taaccacgat tcgacgtcct ttgcatctgc 29100 tatgcacaca accaattatg atccttattt cattaatcgt tggcactgtt tatggaattt 29160 tgtacctttt attcactgcc tttgctgagg tctggatttc acaataccac ttcacttcgg 29220 gattaagcgg tctgacctat atttctctat caattggtca agtatttgcg gtgtttgtcc 29280 ttcttccttt gaaccagaag tattggcttt ctgc 29314 //