ID SPAPB1A11 standard; DNA; FUN; 11203 BP. XX AC AL512486; XX SV AL512486.1 XX DT 03-JAN-2001 (Rel. 66, Created) DT 10-FEB-2003 (Rel. 74, Last updated, Version 2) XX DE S.pombe chromosome I BAC pB1A11. XX KW fluconazole resistance esterase-lipase; FMN dependent dehydrogenase; KW fungal Zn(2)-Cys(6) binuclear cluster; lactate dehydrogenase; KW membrane transporter; RNA binding; spliceosome associated protein 49; KW transcriptional regulatory protein. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-11203 RA Harris D., Wood V., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (03-JAN-2001) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; O14102; O14102. DR GOA; Q9HDX1; Q9HDX1. DR GOA; Q9HDX2; Q9HDX2. DR GOA; Q9HDX3; Q9HDX3. DR SPTREMBL; Q9HDX1; Q9HDX1. DR SPTREMBL; Q9HDX2; Q9HDX2. DR SPTREMBL; Q9HDX3; Q9HDX3. DR SPTREMBL; Q9HDX4; Q9HDX4. DR SWISS-PROT; O14102; SP49_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC BAC pB1A11 is overlapped at the 3' end by cosmid c31G5, CC EMBL entry SPAC31G5, accession number Z98979. XX FH Key Location/Qualifiers FH FT source 1..11203 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="BAC pB1A11" FT /map="IL" FT CDS <1..631 FT /codon_start=2 FT /db_xref="SPTREMBL:Q9HDX4" FT /gene="SPAPB1A11.01" FT /gene="SPAPB24D3.11" FT /product="putative membrane transporter; similar to S. FT pombe SPBC1348.05 and SPAC750.02c and SPBPB2B2.16c FT (paralogs); similar to S. cerevisiae TPO1; similar to C. FT albicans fluconazole resistance protein" FT /protein_id="CAC19726.1" FT /translation="ILISLIVGTVYGILYLLFTAFAEVWISQYHFTSGLSGLTYISLSI FT GQVFAVFVLLPLNQKYWLSAVQKNNGVPEPEFRLPMAFLGCFAIMTGMFIFGWTVQYKV FT FWFVPLIGTTLVGAGFVMTFNPMNMFIVDNYGRYAASAMAAIAIPRNIFGACFPLFAEK FT LFERLGYGWGSSLLAFLLVAINFSIAALYMFGKTIREKRPFDHTKY" FT CDS join(1806..1865,1963..2922) FT /db_xref="GOA:Q9HDX3" FT /db_xref="SPTREMBL:Q9HDX3" FT /gene="SPAPB1A11.02" FT /product="putative esterase/lipase; no apparent S. FT cerevisiae ortholog" FT /protein_id="CAC19727.1" FT /translation="MAELEFTDEKFTKVDPELKEILKKHPAGTENITNIWQMRAMDEEC FT RKQLAETILPLPDDVSVTDILIPTRDGTEIDGRVFTPVSVPADYRSLMVFYHSSGWCMR FT GVRDDDSLFKILTPKFGCVCVSVDYRLAPESKFPVAHNDAIDSFKWVASNIEKLGANPK FT RGFFLGGASAGGNFVSVLSHIARDEKIKPELTGLWHMVPTLIHPADLDEETMAQFRSYK FT ETIHAPVITPKIMDIFFENYQPTPKSPLVNPLYYPTGHKDLPPSFFQCCGWDPLRDEGI FT AYEKALKAAGNETRLIVYEGVPHCFWVYYPMLSLRKKYFEDAIDGFTWLLSHVKKEDD" FT misc_feature 1866..1871 FT /note="gtgagt, splice donor sequence" FT misc_feature 1951..1962 FT /note="ctaaccttgcag, splice branch and acceptor" FT CDS 6119..7342 FT /db_xref="GOA:Q9HDX2" FT /db_xref="SPTREMBL:Q9HDX2" FT /gene="SPAPB1A11.03" FT /product="FMN dependent dehydrogenase; putative cytochrome FT b2 (l-lactate dehydrogenase); similar to S. cerevisiae CYB2 FT but lacking the N-terminal heme binding domain" FT /EC_number="1.1.2.3" FT /protein_id="CAC19728.1" FT /translation="MFRNYNWFDAKEPISYESEIYAKGLKFQRPQITVDGRHWEQLAVE FT RMTKDAAGYVYGCAGKRETYDKNMESFKKWSIIPNRLIKSGFPDLSTTVFGQKYPFPIA FT LAPVGVQKIFNPEGESGSCAAATREHIPYIISTASATSFEDIEKASGPGERWYQLYWPS FT NDHQDITISLLNRAKKTGCRVLIVTLDTFILGWRPSDMDNGYDPFLNPDSIGVEHGFSD FT PVFRKQFKEKHGVEVEENMLEAAKEFAGIVFPGISHDWEDLKFLRKHWDGPIVLKGIMN FT VPDAKKAVEYGMQGIVVSNHGGRQQDGGVASLTMLPKIVDAVGDKLDVLFDSGVRSGAD FT IAKALALGAKMVLIGRPYVYGLALEGSSGVSHVIRCLLGDLELTLHLSGIVSVKPKDLN FT RDVLYKEE" FT misc_feature 6254..7330 FT /note="Match to PF01070 FMN_dh, FMN-dependent dehydrogenase FT Score 380.76" FT CDS complement(7669..9762) FT /db_xref="GOA:Q9HDX1" FT /db_xref="SPTREMBL:Q9HDX1" FT /gene="SPAPB1A11.04c" FT /product="putative transcriptional regulator; zinc finger FT protein; zf-fungal Zn(2)-Cys(6) binuclear cluster domain; FT similar to S. pombe SPAC1327.01C (paralog)" FT /protein_id="CAC19729.1" FT /translation="MIAAVEKDAVPRKRRVISQVSQACIRCRQKKIKCSGEKPSCQACS FT NNKVECIWPDRPNMRGKKPSSAARTLSPLTGIVQPYLGSHPFSPTILSPSSPNMDFTYS FT INSFGDYQKQLRLPTSRKLLQLWDIFLKTSYTELFGIFNKAQITSQIASDTAPPVLVLC FT ICAHAARFSQEEVNRFKSSTAASDYYANQAFSLLPCRFQDISLTNITCLLLLCLIELGS FT CRGAKAWLLLGMALRMVDSLDLGNEINDNPLTMGSNTVSWTEAEQKRRVYWACFFVERL FT LSTGYMAPSKLRSLSLSLQKTSIQLPCPEPNFLFNQPILTELFDGSLPENTQSDTTSMA FT PYQRSLQLEFMTGSLIRLSNLWSEISRWALCGGYTKDITPPWLNQSQFHRSFELLKAWH FT ENLPPRAVWSYTNYSAYSSPGESAGACYTFMHLLYHTTLTYLLRNVLDLFPEKSRQKSK FT LFSSVSQRFGQQPPTVWMDMILDQVITSADFITKLSKDPLNYIMSPFVGFSILTAATIH FT MLLKFCVVNIDQNYISSSRLVHVDHQILQDRSKYWKINQAMLVTLQRLYNFYRFQYLEE FT QSLYNFKIPGFPLCILEYGIVEDQSMKSNPDLNSFSKELFSRGTNELLNNGDDTQSGNS FT TPAMGVSEIRTDTILDEEVPVDPLITSILDDGRWWEEMFGSERKAGFKETVFEDMNGRS FT IRL" FT misc_feature complement(9583..9699) FT /note="Match to PF00172 Zn_clus, fungal Zn(2)-Cys(6) FT binuclear cluster domain Score 52.86" FT CDS join(10729..10840,10898..>11203) FT /db_xref="GOA:O14102" FT /db_xref="SWISS-PROT:O14102" FT /gene="sap49" FT /gene="SPAPB1A11.05" FT /gene="SPAC31G5.01" FT /product="putative pre-mRNA splicing factor (PMID 8598051); FT RNA-binding protein; rrm RNA recognition motif" FT /protein_id="CAC19730.1" FT /translation="MSIREDRNQDATIYLGNLDEKVTDSILFELCLQAGPVVNIHIPRD FT RVRNSHNGFGFCEFLHEQDVEYACQILNQVKLFGKPIRVNRASQDRGVNTLIGANLFVG FT NLDPLVDERVLYDTFSALGQLVKAPQVARDENGRS" FT misc_feature join(10765..10840,10898..11037) FT /note="Match to PF00076 rrm, RNA recognition motif. (a.k.a. FT RRM, RBD, or RNP domain) Score 44.29" FT misc_feature 10841..10846 FT /note="gtatgt, splice donor sequence" FT misc_feature 11104..11203 FT /note="nominal overlap with SPAC31G5 S. pombe chromosome 1" XX SQ Sequence 11203 BP; 3611 A; 1981 C; 2088 G; 3523 T; 0 other; gatccttatt tcattaatcg ttggcactgt ttatggaatt ttgtaccttt tattcactgc 60 ctttgctgag gtctggattt cacaatacca cttcacttcg ggattaagcg gtctgaccta 120 tatttctcta tcaattggtc aagtatttgc ggtgtttgtc cttcttcctt tgaaccagaa 180 gtattggctt tctgctgttc agaaaaacaa tggagtgcca gaaccagaat ttcgcttacc 240 aatggctttt cttgggtgtt ttgccattat gaccggtatg tttatttttg gttggaccgt 300 tcagtacaaa gtcttttggt tcgtgccgtt gatcggaacg acattggtag gagccggatt 360 tgtcatgaca ttcaatccca tgaacatgtt tatcgtcgat aattatggcc gatatgcggc 420 aagcgcgatg gctgccatcg ccattcctag aaatattttc ggtgcctgct ttcctttatt 480 tgcagaaaaa ttgtttgaga gacttggata tggttggggt tcgagtctac tagcttttct 540 tttagtcgcc ataaattttt caatagcagc attatatatg tttggaaaaa ctattcgtga 600 aaagcgtccc tttgatcata caaaatacta ggttttcgaa acaatcgcta tttgtttttt 660 tttttttaat tttaaaaaaa ttaaacatgc attttaaatg attaccaaag tttactaata 720 acccatgaat aatttaaaac cttttttaat ggatccccgc aaccgtctcc acacagaacc 780 taatacttat tcgcgcgcat ttaacattct tctactttaa tcgttggcag gtccaactgg 840 ataggaattg gaatacttta tttcttttct gtactcttaa aacagtattt ttcatatatg 900 ttacctaaat aattttttta tagttttact cattcaatag tttttttaaa aaataataat 960 aataataata attaaactat tcatctttac tctttacaat cgcctacttc cacaaactaa 1020 tattgtagta gctgtagcac ttcatactta cattattttc gcacatttgg ttcttcctgt 1080 aggcagtgtt tcactgccga tcatactcgc ttagtactgc tttatagagc caatgggaca 1140 aggaagggtg cgggtgaata tgcgggttcc ttagccgaaa acatgtgcgg gatctcttat 1200 ttacatggtt tgacacataa ttgtgtacga ttaaataaaa attaattcat caattttata 1260 ctctgataat ctggttgctc ttataggcaa tacctccaaa atattggact cgaaaaccga 1320 actttcaagc gatatttttc tcgtgaaagc acaggctcaa tgaactaaat ttttatttaa 1380 tacaacagaa acaaacactt catactaaac aaaaagaagt tgtgctgaat ttctgtacaa 1440 aatcctctag aagcggccat gcgatgacct gacaagcaag ctgagcggcc cgtgcaagga 1500 gcgctgaaat tttgaaacaa gccgaggatt ctaaggttcc cgatttaaac caacttttag 1560 tatcagagtg aacgtcagtc acgggtatga gtaaataaaa aaagtgaaaa acgtaattcc 1620 ttgagctgat accgaatgca ttcgtgaaaa acaacagtat tgtgattgac gagaatgcgg 1680 aagttacgta attgtcattc tcacagaaac acccgattac tcaaacgaaa ttgatatata 1740 tatgcgggta aagatcaaag tatagaacta ttcataattg taattgatta ctttgaaaaa 1800 acatcatggc agaactcgaa tttactgacg aaaaattcac aaaggttgac cctgaactaa 1860 aggaggtgag ttttaaaaat gagtaccaaa tgtcttaaca tgactttgtt gtcacagttt 1920 gactaaggtc cgttgttttc gttcattgtt ctaaccttgc agatcctcaa gaagcatcct 1980 gctggaactg aaaacattac caacatttgg cagatgcgag caatggatga ggaatgtcgt 2040 aagcaacttg ctgagacaat cttgcctctt cctgatgatg tttcagtcac cgatattttg 2100 attcctacac gagatggaac ggaaatagat ggtagggtgt ttactccagt gtcagtacct 2160 gcagattatc gttctctgat ggtattctat catagctctg gatggtgtat gcgtggtgtt 2220 cgtgatgatg actcactttt caaaattctg actccaaagt ttggatgcgt ttgtgtttca 2280 gtcgattacc gtctagcacc cgaaagcaaa ttccccgttg cccacaatga tgccattgac 2340 tcctttaaat gggttgccag caacattgaa aaactcggtg caaatcccaa acgtggtttc 2400 ttcttaggag gtgcatctgc tggcggaaac tttgtttccg ttttgagtca tatcgcgaga 2460 gatgaaaaga ttaaaccaga gctcactggt ctctggcata tggttcctac acttattcac 2520 cctgcggatt tggacgaaga gactatggca caatttagaa gctataaaga gactattcat 2580 gctccagtaa tcactccaaa aatcatggat atcttcttcg aaaactatca accaaccccc 2640 aagtcacctt tagttaatcc attgtattat cccaccggtc ataaggatct tcctccatcc 2700 tttttccagt gttgtggatg ggatcctctt cgtgatgagg gaattgctta cgaaaaggct 2760 ctcaaagccg ctggaaacga aactcgtctc attgtatatg agggtgtacc acattgcttc 2820 tgggtatatt accctatgtt gtctttgagg aaaaaatact ttgaagatgc aattgatgga 2880 tttacctggc ttttaagtca tgtaaagaaa gaagatgatt aaagaacata ttatagcctg 2940 ttccttttta gcctccttaa aaaaaacgga acttctaaga catgtagatg caatatttat 3000 tcatatgaca acagcagctt gaaatgccaa aaatggtctt tcataacaag cgctgatatt 3060 atacgaggaa gtgataaccg tatttatctc tgcttgattc acacaattaa tgatatatat 3120 tattattcca ttataggaat tgatgtccag agtgatttaa gagtactagc ggaagtcaaa 3180 cgacagaatt agttagcttt gtacaatcgt attgagtagt tgataaacaa acaggagaat 3240 ggttgcaacg ttattctttt ctggcaatta gagattgggg acttttaagt gatttaccga 3300 gaggtgagta tttcaatgct aattttttga acttcttgca tcttactata ctcacgtttt 3360 aaggtaaatt tagcggtgtt ttgtgtagcc ttttccatcc cgatcaatta tttcgagtat 3420 gagtaacaag tcacttgtta aggagaagag gacagagtat ttactaatat atgaagccgg 3480 catataatta ttttgagtaa gtactgtaat ggtataacga tacaattcat aatatctgct 3540 atcatccgaa acttgtgtag ctcccttcag ttaaacgttt ttgatcaatt ttcaaataaa 3600 aattaataaa actaatgcgt tcatttggat tttcttagtg tgattggttt gactagcgaa 3660 attatgatct aggcagtgaa catattcaca atagcaatat ttttcccgtt gtgaaacata 3720 ccgctggggt tcatggccat tcctcagaag tttgacgtct gccttaattt atgcaattca 3780 atatagtaca aagccacttt atcaagaaat catcttcgga agaaagcagg cgtccgggat 3840 ttattgacta tgtgttatcc attgtctctc cacctcttaa attttaaggt actttacctg 3900 ttaaaaggcg cctaagagag attcatcccg cacatacatg tgctggtaga aagatgagta 3960 taatttatga tatggctaac tttaggtgag gtttgctttg aatttatgga ataataaatg 4020 taaaaaagga actttgattt atctactgga ttgaaacttg tcctattcat ttattcattt 4080 tataagaaag gcaagacttg tttcgttaat taacaattgt caattattaa aataaggctt 4140 ttaatattaa aattaattaa ataaagcaac aaatgaactc ttcaaacaac actcatcata 4200 cttaactatt taattatccg tgaacactgg taacaaccaa ttgggtagaa ccgaacgcca 4260 atagtaagag tagctgtttc ataaatctga tattttttaa taaactcatt aataatccaa 4320 ttcacctgtc aaaattctat tccctccaag tcgaggccta gaatgatata ttttggcgga 4380 aggagataaa tccgttaaaa aaatcaaatt atgagttata tcacgttaac caaagatgaa 4440 tgctttcgga gctacaaaat gtattttgct tttaaagtat aacatgttgg aactaattta 4500 gttgtccttt tgtaccaaaa aaataaaatt attataaaac ttccaaaaaa aacataataa 4560 taataatatt tgggataaaa aatacggggt ttttaaattc taatctttaa taactaatac 4620 gacaaactca tttgtactgt atctagaaga aaatttcctt ttgagcactt ttctccttta 4680 agtcttctta cgatgtacat tatttgaagt gacgtaatgt ttcgttatat cgggatagtt 4740 atacttgcat actattataa tctggaattg tggtaattcc agtgtttaag aacgcttact 4800 atgtgatcaa gcaagtagca tttagttaga tttcttgaat acaaccacta ctggttgatt 4860 atagaactgt taatatagct acaagtattg cagaatgcat tttgtgattc tataaatagt 4920 ataacaataa taatagatat tcttgtttct tatcgattat cccatatctg atagttgtga 4980 tgtactttat tttttgttaa atagtttttc accctgacga catatattat gaatctcaaa 5040 gtaccagttt cagcggcgtt ttcggagcaa cacagggtcg tagttatgtc tgttgtcttg 5100 ttacatacca aacattatta tgtattattg acttgatcac ctaaagagtt catcctttgt 5160 catttagacg ttgaattgag tgttgaaacg taaaagtaat aacttttttt ttcttattta 5220 acattataat tttttacaat atcggtcgat acgctttccg gacatcaaac cacccccttt 5280 aattctggcc tcctatagcc tctttagcaa agaatagatt gaacggttta gcaacatgtc 5340 aaagttgcag aacaagacga atccatttgc aaaatattaa ttaccaacct cattacgata 5400 ttatgctata aataatatgc ttaacttact caccattata tcgttataag atatgtcctg 5460 ttggaaaaac tagctagaga aacccacggg cacgtgggcc ttttagtagc aggtaaatca 5520 atgtcagtat tactttgtat attgtagaaa tgaaccgatt tcatgctagc cgttttgcca 5580 tcgtagtata agaaaggatg ctaaatgaac atggactttg tagctgagcg caatacatct 5640 aaattcatta ggaaaataat taatgaaagg tttcatgaaa tcatctctgg ttgtttcaaa 5700 tttggacaaa aacgggattt cgcttttccc aatgggtacg gaaagcgaat tcgtttacaa 5760 atgttttaat atgaaacttg agatgtcata tttacataat ttcgaaaacc aaaagttata 5820 aatgtagcac tgaattgctg taataaaaaa caatataaac tattactttt aaataccact 5880 ttatctgtta agaaatatta aaaaaataca acttcgcctt tatacactcc tcgtcccaag 5940 ttgaaattgt cggtccgata ttttcactca ttcattgcaa tatcagaaga cttttgaacc 6000 ttaaaagtta agaaactcat cattttaatt tctattactt ttttacgaca tttttggatt 6060 cttccctttc tcgaagacat tatctaagta atcaataaat tctcaatacg atttaactat 6120 gttccgcaac tacaattggt ttgacgcaaa agagcccatt tcatatgagt ccgaaattta 6180 cgctaaaggt ctcaagtttc aaagacccca aatcaccgta gatggcagac actgggagca 6240 actggctgtt gagcgaatga ccaaggatgc cgccggctac gtttacggat gtgcaggaaa 6300 aagagagaca tatgataaaa atatggaatc ctttaagaaa tggtccatca ttcctaaccg 6360 tctcatcaag tctggtttcc ccgacttgtc taccactgtc tttggccaaa aatatccttt 6420 tcctattgcc ttggctcctg taggagtaca aaaaattttc aatccagagg gtgaaagtgg 6480 atcgtgtgcc gctgcaacta gagagcatat accctatatt atcagtactg cgtctgcaac 6540 cagctttgaa gatatagaaa aggctagtgg tcctggagag agatggtatc aactttattg 6600 gccaagcaat gaccatcaag acattaccat tagtttgctc aaccgcgcca agaaaacggg 6660 ctgcagagtt ttgatagtta ctcttgacac atttattctt ggatggcgtc cctcagacat 6720 ggacaatggt tacgatccat tcttaaatcc tgacagcatc ggtgttgaac acggattttc 6780 cgaccccgtt ttccgtaagc agtttaagga gaagcatggt gtggaagtcg aagaaaatat 6840 gttagaggca gctaaagagt ttgctggaat tgtctttcct ggaatcagcc atgattggga 6900 agacttgaag ttccttcgta aacattggga tggcccaatt gttctcaaag gtatcatgaa 6960 tgttcctgat gctaagaagg cagttgaata tggcatgcag ggcatcgttg tatcaaatca 7020 tggcggtaga caacaagatg gaggtgttgc ttccttgacg atgctaccaa agatcgtaga 7080 tgctgttggt gataaattag atgttctatt tgactctggt gttcgttcag gtgctgacat 7140 tgccaaggcc cttgcattag gagctaagat ggttttaatc ggtcgtccct atgtttacgg 7200 gttagccctt gaaggttcat ccggtgttag tcatgtcatt cgttgtctct tgggagattt 7260 ggaattaacg ctacatctat ctggtattgt atctgtgaaa ccaaaggact taaaccgtga 7320 tgtcttatat aaggaggaat aaatttatgc attagttaat gatcagcaaa tttagtttaa 7380 ttcccgttat accatttaat atttatttac gctatgagta atataaaact acccattaat 7440 aagaatatga gtaacttata ttaataagca taaaaagcaa tcaataagtg ttatgagaaa 7500 ctgactcaag taaccagttc catcaatatc attaatttcg agttcgtgaa taaaaggaat 7560 tccaggggtg tagaaaaagt aaagcattat aagcttttta aattagagtg ctagtataca 7620 aaagaataaa gaaacaaaaa ctaaagaaac tattgtacat cgtataattt acaatcgaat 7680 acttcttcca ttcatgtctt cgaacaccgt ttccttaaaa cccgccttcc tttctgatcc 7740 aaacatttcc tcccaccagc gaccgtcatc taaaatcgaa gtgatcagtg ggtctacggg 7800 gacttcctca tccagaatag tatcagttcg tatttcagaa acacccatag caggtgtcga 7860 attcccactt tgagtatcat cgccattatt caaaagctcg tttgttcctc ttgaaaacaa 7920 ctcttttgaa aatgaattca gatcaggatt agacttcatc gactgatctt ccactatacc 7980 atattctaga atacataaag gaaatcctgg aattttgaaa ttgtaaagtg actgttcctc 8040 taaatactga aagcggtaga aattatacaa tctctgaaga gttaccaaca ttgcttgatt 8100 aattttccaa tatttggatc gatcctgtaa aatctgatga tcaacgtgta caagtcgaga 8160 ggaagaaatg taattttggt cgatgttgac aacacaaaac ttaagaagca tatggatagt 8220 agcagcagtc aatatactaa accccacaaa tgggctcatt atgtagttta aggggtcctt 8280 tgaaagtttt gtaatgaaat cagcagaagt aatgacttga tctaaaatca tatccatcca 8340 tacagtagga ggctgttgtc cgaagcgttg tgaaacagag gaaaaaagtt tggatttctg 8400 cctcgacttc tcaggaaata aatctaagac gtttctcaga agataggtca aggtagtgtg 8460 atatagcaaa tgcataaaag tgtaacaggc accagccgat tctccgggag aactatacgc 8520 cgaatagtta gtgtatgacc aaactgctct tggaggtaaa ttttcatgcc aggcttttaa 8580 aagctcaaag ctacgatgga attgagactg atttagccaa gggggtgtga tatctttcgt 8640 gtatccacca catagagccc atcttgagat ctcactccac aaatttgaca agcggattag 8700 ggaacccgtc ataaactcca gttgtaaact tctttggtat ggggccattg aagtggtgtc 8760 tgactgagtg ttttccggta aagatccatc aaataactca gtaagaattg gctgattaaa 8820 taaaaaatta ggttccggac aaggtaattg tatactagtc ttttgaagag ataaagaaag 8880 tgagcgcaat tttgaaggtg ccatgtaacc tgtacttagc aaacgttcga caaaaaaaca 8940 agcccaataa acccttcttt tctgctcggc ttcagtccat gaaacagtgt tggatcccat 9000 cgtaagagga ttatcattta tttcgttacc aagatctaaa gaatcgacca tacggagagc 9060 catacccagt aaaagccagg ctttagcgcc tctacaagag cccaactcaa ttaagcaaag 9120 caagagcagg caagtgatat tagtcagtga aatatcctgg aaacgacaag gaagcagtga 9180 aaaggcttgg tttgcgtagt aatcagatgc tgcagttgaa gatttaaatc tattgacttc 9240 ctcttgactg aaacgagcag cgtgagcaca tatacaaagt acgaggactg gcggagcagt 9300 atcacttgca atttgagacg taatttgggc cttattaaat atcccaaaaa gttcggtata 9360 tgaagtttta agaaatatgt cccaaagctg taataacttt ctactggttg gtagccttaa 9420 ctgcttctga tagtcaccaa agctattaat agagtaagta aaatccatgt taggagatga 9480 tggagagagg atcgtaggag aaaaaggatg agagcccaga tacggttgca ctataccagt 9540 aagaggactc aaggttctgg cagcggaaga tggctttttg cctcgcatat tcggtcgatc 9600 aggccaaatg cattcaactt tgttgttact gcaagcttga catgatggct tttcaccaga 9660 acactttatt tttttctgcc tacaccgaat gcatgcctga gatacttgac tgattactcg 9720 cctttttcga ggcacagcat ctttttcgac agcagcaatc atgtcgaaaa taaaatacta 9780 aaatgaagta ataaaatatt ctgtgtcctt ttaaaccgtt taaaaaccta gataatcgaa 9840 gaaatcctgc gttgagtaga caggtcttaa aaaagaaaag aaaagaaaag cagacgtgcc 9900 aattgtctga tcgtacgtct gttagaaaaa gctcacgagc ttaaatcaga aaaaataaat 9960 aagcaataaa cgtaaaggct acgaacagtc ctttcgaaaa gtttgcaagt agaaaattaa 10020 acataaacaa taatagactt aagtgaaaga aaaaaggggc atctaggact acacaagtac 10080 gctttttcaa aacaccaaca tcacagaaat attttgatta aaaacacact cgaaaagcta 10140 taaaattcaa ctgaagtcgt ggtatcacct gaagggtgaa gatcataaga aggttacaaa 10200 gaccacatgg gagtaaaaag cccatctagg gtaacataaa taagccctca gttgtgttca 10260 aaactacagc agcaaaaata aatatacatg gccaaacatc gtttttacaa aaagttaata 10320 aatgaaccta ttaaatgtac tagtgtacga tggatgtaag gaaattaggg ctgtataaag 10380 agataggttg ctataaaaaa tatttcgtca gtctaccatt cacaactgta ccttcaactt 10440 gaatataatt caatctcatg agtaaaatta taaaataata aaaaaaaaac gaagatttag 10500 tattaaaaat ctccataaat gtgtttggaa aacgctggac actgaaattt taacgatgaa 10560 tactgtaatt tagttttcta ttgtgctatt tggtgctcgt cattaagtca ataacgagac 10620 tatgcaccaa tttcttgaat cttctaccag cgtcttcaaa cgtgtctatc tatttattct 10680 aataaatttc tataatagac actttaactt atttttactt atttattaat gagtattcga 10740 gaagacagga atcaggatgc aactatatat cttggcaatc ttgatgaaaa agtaacggat 10800 tctattttgt ttgagttatg cctgcaggca ggtccagttg gtatgtaatt attcgagtgt 10860 tggttgtatt tgtggctttc gatactaatt catacagtaa atattcatat tccaagagat 10920 agagtaagga atagtcataa tggctttggt ttctgcgaat tcttacacga acaagatgtt 10980 gagtatgcat gtcaaattct gaatcaagta aagttgtttg gaaagcctat aagggtcaat 11040 agagctagcc aggacagagg agtcaatacc ttaattggtg caaatttatt tgttggcaac 11100 ttggatcctc ttgttgatga acgcgtattg tacgatacat tttctgcttt gggacaactt 11160 gtcaaggcac ctcaggtagc aagagacgag aatggaaggt cga 11203 //