ID SPAPB18E9 standard; DNA; FUN; 14089 BP. XX AC AL691402; XX SV AL691402.1 XX DT 12-MAR-2002 (Rel. 71, Created) DT 12-MAR-2002 (Rel. 71, Last updated, Version 1) XX DE S.pombe chromosome I cosmid pB18E9. XX KW . XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-14089 RA O'Neil S., Harris D., Wood V., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (11-MAR-2002) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA E-mail: RL barrell@sanger.ac.uk XX DR GOA; Q8TFG6; Q8TFG6. DR SPTREMBL; Q8TFG2; Q8TFG2. DR SPTREMBL; Q8TFG3; Q8TFG3. DR SPTREMBL; Q8TFG4; Q8TFG4. DR SPTREMBL; Q8TFG5; Q8TFG5. DR SPTREMBL; Q8TFG6; Q8TFG6. DR SPTREMBL; Q8TFG7; Q8TFG7. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC BAC pB18E9 is overlapped at the left by cosmid c11G7, EMBL entry CC SPAC11G7, accession number Z99161, and at the right by BAC pB15E9. XX FH Key Location/Qualifiers FH FT source 1..14089 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="BAC pB18E9" FT /map="IR" FT misc_feature 1..105 FT /note="nominal overlap with SPAC11G7 S. pombe chromosome 1" FT CDS join(165..340,396..484,529..630,734..987,1048..1284, FT 1340..1687,1737..1838) FT /db_xref="SPTREMBL:Q8TFG7" FT /gene="SPAPB18E9.01" FT /product="putative tRNA modification enzyme, or involved in FT methionine biosysnthesis (see Pfam); similar to S. FT cerevisiae TRM5" FT /protein_id="CAD27467.1" FT /translation="MHLQIRTVHNMAELLHPNKVEMKPFLKNLDKNLFKKTYNLVAAKV FT SPKKVGLLNKVCKKDLLDWPRVKHVYQQNNEKLVLLNRDASLDGTRGLSDATVSFIKEN FT NIELVPFQLTLDYDYWRADDILDAILPPGEKEDHPSGFTAVGHIAHMNLREEWLPYKYI FT IGKVILDKNPSIETVVNKTDTIDTKFRTFQMEVLAGKDDFIVTQSESNCKFRFDFSKVY FT WNSRLSTEHDRLIQQFQPGDAVCDVMAGVGPFACPAGKKNVIVFANDLNPYSYESLVEN FT IFLNKVANFVKAFNQDGREFIRSSVQKLLGFSKDEKAITVFPPRKRARKLEENKDPVRQ FT DIPIPPVFSHYVMNLPGSAIEFLDAFKGCYYGLEYLFKDRSLPKVHVHCFCRFPDPEED FT LINRIYASLGYRFSPEEVDFYYVRKVAPNKVISFFI" FT misc_feature 341..346 FT /note="gtatgc, splice donor sequence" FT misc_feature 380..395 FT /note="ttaactaaatttttag, splice branch and acceptor" FT misc_feature 485..490 FT /note="gtaaag, splice donor sequence" FT misc_feature 518..528 FT /note="ctaatttcaag, splice branch and acceptor" FT misc_feature 631..636 FT /note="gtagga, splice donor sequence" FT misc_feature 716..733 FT /note="ctaacaacttttacttag, splice branch and acceptor" FT misc_feature 988..993 FT /note="gtatgg, splice donor sequence" FT misc_feature 1030..1047 FT /note="ctgatgaatttattttag, splice branch and acceptor" FT misc_feature 1285..1290 FT /note="gtataa, splice donor sequence" FT misc_feature 1324..1339 FT /note="ctaactagctattaag, splice branch and acceptor" FT misc_feature 1688..1693 FT /note="gtatga, splice donor sequence" FT misc_feature 1719..1736 FT /note="ctaaccaagtttttttag, splice branch and acceptor" FT CDS join(complement(6414..6544),complement(2225..6044)) FT /db_xref="GOA:Q8TFG6" FT /db_xref="SPTREMBL:Q8TFG6" FT /note="pB18E9.C.cand.3 score = 83.45" FT /gene="SPAPB18E9.02c" FT /product="putative serine/threonine protein kinase; similar FT to S. cerevisiae RIM15" FT /protein_id="CAD27468.1" FT /translation="MVMQERNSNEDNKVNHGIDNIYVLELDLDGSVLFASTNFSQITGS FT LELTGKPAALLSSDQEIFNAAIEQLLDDDSHSVKIHTVISKLPSLEENVFVQDEEMELQ FT SKSVELDCVGVLIRDPLTSRPSHTLWVLQPLKPTRITRQEIGQQLTETLGFGAQLLAQH FT LEKLQTVPSTDSLPPFETVLCRVCDHEIQNWYFEHHTELCLLIHHAEARAQEANDLLNE FT QRNALQSLLDSLDDQIEPDVSYLGVPLAAVLPSSITSSAKSNSRSSLSQKIRNYISNML FT FDAISYTDSCLAIHLPFIPESTTREDNQPFSEIRLLSPASEVFNAKTLSWCLPHIDDPG FT LQLMFENTDALVKKKLDAINRLSNIIYYSERVRCEIEDQVQTIIEQSIQVDGYDEPLST FT TTPTLIEPIQETLMTQSPIIECEPFNTVKPSVSPEEVHDISQFNHRNDPPITAASVDSS FT NSFSVHRSSTNHSSTNSGSPNLSRRNNLAIPIASRRKSVSAVNTLYGVGSSYTSESFPF FT SKLTVPVERNSFRETESPKPFLSRQIGISTLSSNISSGKGTPSIQDYEIIKPISKGTFG FT TVYLSRKNTTGEIYAIKVLRKVDMISKNQVANVKAERAVLMAQEESAFVAKLYYAFQSR FT DYLYLVMEFMNGGDCASLLKSLYTIPESWAKIYIAEVALGLEHLHRLGIIHRDIKPDNI FT LMSITGHLKLADFGLSQLGLTTRQLRLQKGKNNILSPPSFQSPTALGDPGDNIASSPLI FT LPTSVSAFSYDEKSQKQKTELATFTTYKEDDTTTTTRTSIDSISSKYLESPVDSQKVNR FT TPNLQSVPFFRQPDAPKRFVGTPDYLAPETLRGSTQDDMVDWWALGCVLFEFLFGYPPF FT HAETPEKVFENILANNIAWPDLEMYPCSEEALDLINGFLQPNPERRLGFSDINEIKEHP FT FFNGINWDDIFSHEAPFIPAPETPLDTAYFDSRGAGAAESNMSSSVNSGEEVSKDNNVS FT QERGSQFLRSSHGRSRERSTSARRSRRFSEANSEFDEFGPFSYKNLSVLERANRNAIEK FT IRSEIAGKLHISPPDPHIGYTPGSDMPSAKLYDQQLTLSPSLMTNQGSNFSSTDSTPRK FT SINSSDVESRSKTDGPKSMHDLIKQLHMRKHSSHTNQSTGSSESDDLFNLDLPISNLET FT SYPFKIEEGQASPLSSPLSKTPPFFSSSVPLKALICVSKLNLFSELIKLLKSYKFQVSI FT VTDEDKMLRTLMADEKFSIIFLQLDLTRVSGVSILKIVRSSNCANRNTPAIALTPTRID FT INAAIPRMFDGRLYLPINAFLLRGYIARLCNK" FT misc_feature complement(6045..6067) FT /note="ctaaccaagttgcatagaattag, splice branch and acceptor" FT misc_feature complement(6408..6413) FT /note="gtaagt, splice donor sequence" FT CDS join(complement(8161..8170),complement(8034..8053), FT complement(7833..7937)) FT /db_xref="SPTREMBL:Q8TFG5" FT /gene="SPAPB18E9.03c" FT /product="very hypothetical protein" FT /protein_id="CAD27469.1" FT /translation="MFSIVKEEVGLPGMIIYFLLQISISRCVFSKNGFYHVCNKMINL" FT misc_feature complement(7938..7948) FT /note="ctaataaacag, splice branch and acceptor" FT misc_feature complement(8028..8033) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(8054..8064) FT /note="ttaatttcaag, splice branch and acceptor" FT misc_feature complement(8155..8160) FT /note="gtaagt, splice donor sequence" FT CDS complement(8557..10959) FT /db_xref="SPTREMBL:Q8TFG4" FT /note="pB18E9.C.cand.2 score = 42.11" FT /gene="SPAPB18E9.04c" FT /product="putative glucoamylase; similar to S. cerevisiae FT STA1; similar to S. pombe SPBPJ4664.02" FT /protein_id="CAD27470.1" FT /translation="MNRFFISTLLLLAQHLAPAAASCGLANEASLSANEVQDIYHDFVA FT TSINYADLLKRNEDLNASLSTGSPVEITSTSCTTDTSASTPIITESTSSTSSASTTGSS FT SSPLPSTSTSCTTSTSIPPTGGSSSLSTPITPTVPPTSTSSTSIPIPPTSTSSTDTNSN FT PLPTTSTSCTTSTSIPPTGGSSSLSTPITPTVPPTSTSSTSIPIPPTSTSSTDTNSSPL FT PTTSTSCTTSTSIPTGGSSSLSTPITPTVPPTSTSSTSIPIPPTSTSSTDTNSSPLPTT FT STSCTTSTSIPPTGNSTTPVTPTVPPTSTSSTSTPPPPASTSSTGTSSSPLPSTSTSCT FT TSTSIPPTGNSTTPVTPTVPPTSTSSTSTPPPPASTSSTGTSSSPLLSTSTSCTTSTSI FT PPTGNSTTPVTPTVPPTSSSTPLTTTNCTTSTSVPYTSTPVTSTPLATTNCTTSTSVPY FT TSTPVTSTPLTTTNCTTSTSIPYTSTPVTSTPLTTTNCTTSTSVPYTSTPVTSSNYTIS FT SSTPVTSTPVTTTNCTTSTSVLYTSTPVTSTPLATTNCTTSTSVPYTSTPVTSSNYTIS FT SSTPVTSTPVTTTNCTTSTSVLYTSTPITSPNSTSSSSTQVSWNSTTPITGTSTSKVTS FT STSIPLTSTNRTSTTFTSSTSISTSSSSTATSSTSFASESSSFYSNVTTSSSTVSTPPP FT TTSFPSTFTTSFITSSSLSSIPNNSTEVKTASTSSGTEIKTASTSSGSSSSSSYTPASS FT TSTTTSSVSSRQSSSSSSFTPSSAISTAKSSFVLSTLSILIALYMVA" FT CDS complement(12503..12775) FT /db_xref="SPTREMBL:Q8TFG3" FT /note="none" FT /gene="SPAPB18E9.05c" FT /product="hypothetical protein; sequence orphan" FT /protein_id="CAD27471.1" FT /translation="MNEVISQPPCNIFRPLILSMHLSPVSILSPVLLIYLVIHSQNELV FT SMSWLFRSTICFGVSLFLSFFLVRILWGIAYSYNSNSMSIYFSYI" FT CDS complement(13094..>14089) FT /codon_start=1 FT /db_xref="SPTREMBL:Q8TFG2" FT /gene="SPAPB18E9.06c" FT /gene="SPAPB15E9.01c" FT /product="hypothetical protein; sequence orphan; low FT complexity protein; similar to cell surface proteins" FT /protein_id="CAD27472.1" FT /translation="TVAPTSTFTSSGFNTTSGLPTSSVSTPLSNSSAYPSSGSSTFSRL FT SSTLTSSIIPTETFGSTSGSATGTRPTGSSSQGSVVPTTSTGSSVTSTGTGTTTGVTEV FT TETSTFETTEIITSTIEPTTASGTGGGNPTAAPTNEPTVTTGTETTEGTATYTEPTTFT FT STFSFTTTIIGGTTTIIPVNPGNPSSSVSAPPTTSFTPGPGGSGYPSYSNTTQGMNTTS FT IWNSSNSTIVSNVTATITGNVTITTGDLTTIDPTTFTSTYLSSGFQTVSNTTATSGSDD FT DVKTASTSSSTSYTSSSSSSSSTTSAASSKASVSMGLNGLMIAAVILLVA" FT misc_feature 13974..14089 FT /note="nominal overlap with pB15E9 S. pombe chromosome 1" XX SQ Sequence 14089 BP; 4583 A; 2430 C; 3047 G; 4029 T; 0 other; aattaaatca gttcggctaa ctttaatctt ccataaagca agcagagctt aattgttaaa 60 aatatatgta ttttatatga tgtgttccat aaaaaaacaa ggatcaggtt cataaagcga 120 tttttaagac gcagtccaat ctcacctcaa atgtgttttc acacatgcat ttacagatta 180 gaactgttca caatatggca gaattattac atccaaataa agttgaaatg aagccattcc 240 ttaagaattt agataaaaat ttgtttaaaa aaacatataa tcttgttgca gccaaggttt 300 ctcctaaaaa agtgggactt ttaaacaaag tctgcaaaaa gtatgctaaa tttttccatt 360 agggtaattt tgatatcatt taactaaatt tttagagacc ttttggattg gcctcgtgtt 420 aaacacgtat atcaacaaaa taacgaaaaa cttgtacttt tgaatcgtga tgctagcttg 480 gatggtaaag acaagatttt ttatttataa ctgtatgcta atttcaaggt actcggggtt 540 tatcggatgc taccgtatct tttattaaag aaaataatat agagttagtt ccttttcagt 600 tgactttgga ctatgactat tggagagcag gtaggattat ttgaatcgta aattgcaata 660 aacacatata gcgtcgtcgt ctcttctttt cgagatttat ttgttgtagc ttctactaac 720 aacttttact tagatgatat actggatgct attttacctc ccggcgagaa agaggatcat 780 ccttctggct tcaccgctgt tggacatata gcacatatga acttacgtga ggaatggctt 840 ccttataaat atatcattgg aaaagttatt ttagacaaga atccttctat tgaaaccgtt 900 gttaacaaaa ctgacactat cgataccaaa tttcgtacct ttcaaatgga agtattggcc 960 ggaaaggatg attttatagt tactcaggta tggctattgg tcaactttca gcaattaaga 1020 tttgctttac tgatgaattt attttagtct gaatcaaact gcaaatttcg atttgacttc 1080 tccaaagtat attggaattc acgccttagc actgaacatg accgtttgat acagcaattt 1140 caacctggag atgctgtttg cgacgtaatg gcaggagttg gcccatttgc ctgtccggct 1200 ggaaaaaaaa atgtaatcgt gtttgcaaac gatttgaatc cttacagcta tgaaagttta 1260 gttgagaaca tttttctaaa caaggtataa acttcagctt ggtcaaaagc ttgtgagata 1320 atgctaacta gctattaagg ttgcgaattt tgtaaaagca ttcaatcaag atggtagaga 1380 atttattcgt tcctctgttc agaaactatt aggattctct aaagatgaaa aagccattac 1440 agtctttcct ccgagaaagc gagcacgtaa attggaagaa aataaagatc ctgtgagaca 1500 ggatattccc atccctcctg tattttcaca ctatgtaatg aatttacccg gatcagcgat 1560 tgaattttta gatgctttca aaggttgtta ttatggattg gagtacttgt ttaaagaccg 1620 ctctcttcca aaagttcatg ttcactgctt ttgtagattt cccgatcctg aggaagatct 1680 tataaatgta tgaaatgctt actttaaatg aaaatttact aaccaagttt ttttagcgga 1740 tatacgcttc gttggggtat cgtttttctc ctgaagaagt tgacttttat tatgtccgaa 1800 aagttgctcc caacaaggta atatccttct ttatatagca cttttaatgt aactaactaa 1860 acaactagga tatgtactgt tgtactttca cgttacctgg ttctataata tttgctaaac 1920 cggtttcagg ttagtcttta taggattgaa atgtcgttca ggagaagatg agctattttg 1980 ggcttattat tttttcatta ctttaactgt tacatatcct gtagaaaaaa cctcagtaaa 2040 aataaaagtt ataaatccaa aaaagtcttg taagttgaca aaagtaaact tttttcaaaa 2100 aaattagtgt tattaatatt attactatta taattattat acattcgaga aacaaaaagg 2160 aaaaaattaa agagagtatg gtaacaacaa aaaatgagca atcacgatta acaaacgttt 2220 gaactcattt attgcaaagc cgggctatat aaccacgtaa aaggaacgcg ttgataggca 2280 agtataaccg tccatcaaac atgcgaggaa tagcagcatt aatatcgatt ctggtaggtg 2340 tcaaagctat agctggcgta tttcgattag cacaattact tgatcgaaca atctttaata 2400 tagaaacacc agaaacacga gttaaatcta attgcagaaa tatgatcgaa aacttctcat 2460 cagccattaa agttcttaac attttgtcct catcggtaac aatagatact tgaaacttgt 2520 atgattttag taacttgatc agctctgaaa acaaattcag cttgctgaca catatcaaag 2580 cctttaaggg gactgaagaa gagaaaaaag gaggggtctt tgagagtgga gaagacaaag 2640 gagatgcttg accctcctca attttaaacg gatatgaagt ttccaaattc gaaatcggaa 2700 gatcaagatt aaaaagatca tcactttcag aagaaccagt tgattgattc gtatgagagc 2760 tatgctttcg catatgcagt tgcttaatca aatcgtgcat tgacttcggg ccatcagttt 2820 tagaacgaga ttcaacatca gaactgttaa tggacttcct aggtgttgaa tcagtggaag 2880 aaaaattaga gccctggttt gtcattaaag agggacttaa agttagttgc tgatcataaa 2940 gttttgcaga aggcatatcg gaaccagggg tgtatccaat gtgtggatcc ggaggggata 3000 tatgtaattt gccagctatt tctgatctta ttttttcaat agcatttcga ttagctcttt 3060 ccaaaacgct taaattttta taagaaaagg gaccaaactc gtcaaactct gagttagctt 3120 cgctaaatcg gcggcttcta cgagctgacg tacttctctc acgactgcga ccatgagatg 3180 aacgaaggaa ttgtgaacct ctttcctgag aaacattatt atccttagaa acttcctctc 3240 cgctatttac agatgagctc atgttagatt ctgcagcccc agctccacga ctatcaaaat 3300 atgcagtatc aagtggggtt tctggtgcag gtataaaagg agcctcgtgt gaaaaaatgt 3360 catcccaatt aatcccatta aaaaaaggat gttctttgat ttcattaata tccgaaaacc 3420 caagtcgtct ctccggattt ggctgtagaa acccattaat caagtctaat gcttcctcgg 3480 aacaaggata catttctaaa tcgggccatg caatgttatt agccaaaata ttttcaaata 3540 ccttttccgg ggtctctgcg tgaaaaggtg gataaccaaa cagaaactca aacaacacac 3600 agccaagagc ccaccaatca accatatcat cctgtgtact tccgcgaaga gtttcaggtg 3660 ctaaatagtc aggagtacca acgaatcttt taggagcatc aggttgtcta aaaaaaggaa 3720 ccgattgtaa attaggagtc cgattgactt tctgagagtc aactggactt tctaaatatt 3780 tactagagat gctatctatg ctcgtacgag tagtagtagt ggtatcatcc tctttatacg 3840 tagtaaatgt agccaactct gttttttgct tttgcgattt ttcatcatac gaaaaagcac 3900 taacactggt aggtaaaatc aagggagaac tggcaatatt atcaccggga tcacccaacg 3960 cagtaggaga ttgaaagctg ggtggtgaca aaatattatt tttacccttt tgtaaacgta 4020 attgccgtgt agttaaacct aactgactta agccgaaatc cgctaatttc agatgtccag 4080 taatactcat aaggatattg tccggtttaa tgtcacgatg aattatacca agcctatgta 4140 aatgctcaag acctaatgca acttcagcaa tgtaaatttt tgcccacgat tccggtatag 4200 tgtacaacga ttttaatagg gatgcacaat cccctccatt catgaattcc ataacaagat 4260 agaggtaatc cctactttga aaggcataat acaattttgc aacaaatgca gattcttctt 4320 gcgccataag cacagccctt tcagctttca cattagcgac ctgatttttt gaaatcatgt 4380 caacttttct taagacctta atggcgtaaa tctccccagt ggtattttta cgggaaaggt 4440 aaacagtgcc gaaggttcct ttactaatag gctttataat ttcgtaatct tgaatagaag 4500 gagtcccttt accactgcta atgttggatg acagtgtcga tatgccaatc tggcgactca 4560 aaaatggttt tggtgactct gtttcacgga aagaattacg ctcaactggg acagtaagtt 4620 tactaaaggg aaaactttca gaggtatagg aagaaccaac tccatataaa gtattaactg 4680 cactcacaga ttttcttcta gaagcaatgg ggattgcaag gttgttgcga cggcttaggt 4740 tgggagatcc actattagta ctactgtgat ttgtagagga acggtggact gaaaaagaat 4800 tggatgaatc aacactagca gcagtaatcg gcggatcatt cctatggttg aactgtgaaa 4860 tatcgtgcac ttcctcagga gaaacagaag gcttaactgt attaaatggt tcgcattcaa 4920 taataggaga ttgtgtcata agggtttctt gaattggttc aataagtgta ggagtcgtag 4980 tactgagagg ttcgtcataa ccatcaactt gaatggattg ttcaataatg gtctgcactt 5040 gatcttcaat ttcacaacga acacgctcag aataatagat gatgttgctg agacgattaa 5100 tggcatcaag cttttttttt actaaggcat ccgtgttttc aaacatcaat tgcaacccag 5160 ggtcatcaat atgtggtaag caccatgaaa gagtttttgc attgaaaacc tcactagctg 5220 gtgataataa gcgtatttca ctaaatggtt gattgtcttc cctggtagtg gattctggta 5280 tgaaaggtaa atggatggct aaacaactat ctgtataact tatggcatca aacagcatgt 5340 tactaatgta atttctaatt ttttgggaca acgatgaccg ggaattcgac ttcgcggagg 5400 aagtaataga ggaaggaagg acggcggcga gaggaactcc caaatatgat acatctggtt 5460 ctatctgatc gtccaaagaa tccaacaaac tttgtaaagc atttctttgt tcgttaagaa 5520 ggtcatttgc ttcttgagca cgtgcttcag catggtgaat gagaagacaa agttcagtat 5580 gatgctcaaa gtaccaattt tgaatttcat gatcgcaaac cctgcaaagt actgtttcaa 5640 agggaggaag actatcggtg gaaggaacgg tttgaagctt ttcaagatgt tgggccagta 5700 actgagctcc aaaacctaga gtttctgtga gttgctggcc tatttcctga cgagtgattc 5760 gcgtgggctt caaaggttgc aaaacccata atgtatgaga gggtcggctg gttaagggat 5820 cacgaatgag gacaccaacg caatccaatt cgacagactt tgattgcagc tccatttcct 5880 catcctgaac aaagacattt tcctccaagg agggcagctt cgaaatcacg gtatgaattt 5940 taacactgtg ggagtcatcg tcaagaagct gttcaatggc tgcgttgaat atctcctggt 6000 cggatgacag aagagctgca ggtttgccag taagttctaa cgaactaatt ctatgcaact 6060 tggttagtaa aagacctagc aataaattga aaaagagcaa gatttcaaaa gttgaaggac 6120 agaggcgacc caaggagtat cagccatagc ttggccaatc cagcttaaaa gaactaaaac 6180 aggtcggcag caaatagaag atttaagtat tatacgtatg acttacagat caaggcaatt 6240 gaagccttat tcaatggcta tttttgcgta atctgcaaag tcataccaac cgaatcgtta 6300 aaagaaagat acaaattaaa tgtacaatat aaatattcta gcaagcaatg gtatccttct 6360 gccaacaaca cagagaaatt tcgtaacatc gcccgctatt ccactgcact tacccggtaa 6420 tctgtgagaa gtttgtactt gcaaacagca cagatccgtc taaatctaac tccaagacat 6480 aaatgttgtc tattccgtga tttactttgt tatcctcgtt ggaattgcgt tcttgcatta 6540 ccattaactt tataactcca ttcagatttt gatcctaatg tgcgacaagt aaaaccattc 6600 gaatacaatt agcgtttcgt tatttcataa aacccaatct atcgactaaa aaaacataga 6660 caatacggta accaattgat attctaatca aacacccaat ttatgaacgt gggtggctct 6720 tgatgactgt gtcaatattt atatgagtga gcagtgcgta gaggctaatc attgttaccc 6780 tgggacgatt gatacctgtg cttacttatc ccttgatcag gattcactaa ggggagagat 6840 cgcgagccga tgtcttaaat aacgatttcg atggcaataa ttatataatt atatatcgtt 6900 gatcgctata cttcggttta tgaattttca ttgcaagatg aaaaaaggtt ggtgattgaa 6960 aggaaagcga gacaatgtaa tgcaagctgt agaaatgcgg attttttttg gaaatgtctt 7020 ccatgatgtg ttattctgct ttcatttctg taacatgatt ttgcgcggaa aggtctcaaa 7080 caaaagtgcg actgcgcgca tgcacgtatg cgcttaatcc gcttagtacc aattatagat 7140 ggaggattga tattttggca gttaggatta aaacctgttc ttcttcaatc cctctttaaa 7200 gcagggatac cctccttgca gcccaactat tcctccgatt cgcactacta atttgttcac 7260 aggctaatgt ttacagatct gttggaatag ggatgaatgc gcccattcat agtgttgaaa 7320 ataggatatt cgagttgctt tgtttagaca ccccatcatt caatatgctc acagctgtgt 7380 tggtaaggaa tgcatatgta ttattgatgc ataaggagtt accaatttgt taatagataa 7440 gtaggtcata actgctattc ttttccaaaa tcataatttc tgtcgctttt cattagtacc 7500 tgctgaataa aattggtaat ggatgggtca tcagagaaac cgttttctgt accggatttt 7560 acactcccac gctctcatgc acagcgttct aataaatttc cgtatatctt aaaagaatac 7620 attatactct atgttaagat catatttcca aattcgatta cttgacagtt gactaaaaga 7680 gtgtatagcg tgtacactac cacaaagaaa agttccattt tagagttgaa cccccgaaat 7740 tcattcgaaa agcaaaacga tttcctttac tatgtttttt ctaaattttc catatcgtaa 7800 cgaaaatttt ggtagggaga ataactcact catcacaagt tgatcatttt attgcataca 7860 tggtaaaacc catttttaga gaaaacgcat cggctgatac taatttgcaa taaaaaatat 7920 attatcatcc ctggcaactg tttattagtt ttaggttagc atgggaagaa cagtggtgtg 7980 gaaaacggtt aaattaggaa ttgctcgata attcaagcac atggaaaact tacaccaact 8040 tcttctttaa caacttgaaa ttaacgtctc catcattgtc gtattcataa tagtgcaata 8100 ttactgtata atctaacaac ttacacaata caatattagt tattcttagc tacaacttac 8160 ttgaaaacat taatcacatg acttttctta taagctaaag attcattata tttcgaaatg 8220 aaattacgag atgttaaaga atcacgaatt caaaaaaata gacgaccata acagtgtcag 8280 gtttcttaga tactctgctt tactaacata gcgggcagaa atataaaaga ttcttgagat 8340 gcagttatgc tcgtaaaaaa taaataaccg ataaccgctg tgaacgagaa caaaaaaagc 8400 acatgaaaaa gccttgagct cagtttagct aatcgataat tcgaatgaac atagagaagt 8460 ttatattatt cagcggtcac cacgatcata caaacaacaa accatcagat atatttcatc 8520 aaaccacaag ttaaattttc atcgcatacc aatcacctaa gcgaccatat aaagcgcaat 8580 aagaattgac aacgtactca atacgaaaga gctttttgcg gtagaaatgg cagaagaagg 8640 agtgaatgaa gagctgcttg acgattgcct tgaactgaca ctgctagtag tagtagaagt 8700 agacgaagca ggagtatagc tcgagctcga gctgctaccg ctagaagtgg aagccgtttt 8760 aatttcagtg ccactagaag tggaagctgt cttaacttcg gtagagttat taggtatgct 8820 actaagcgaa gagctagtaa taaacgaggt ggtaaacgta ctagggaaag aagtagttgg 8880 gggcggagta ctaaccgtag aactcgaagt agtaacgtta ctatagaatg aagaactttc 8940 gctagcaaaa ctggtagacg aagtggcagt agaactacta gatgtactaa tactggttga 9000 agaagtaaaa gtagtagagg tacggttggt cgacgtcaaa ggaatcgagg tactgctagt 9060 aactttagaa gtggaagttc ctgtgatggg tgtagtgctg ttccaactaa cttgagtgga 9120 agaactagat gtagagttcg gactggtgat aggagtactg gtataaagga cactagtact 9180 ggtagtacaa ttcgtagttg tgacaggagt gctagtgaca ggagtactgg agctaatagt 9240 atagttcgaa ctggtaacag gagtactggt ataagggaca ctagtactgg tagtacaatt 9300 cgtagttgcg agaggggtgc tagtgacagg agtactggta taaaggacac tagtactggt 9360 agtacaattc gtagttgtga caggagtgct agtgacagga gtactggagc taatagtata 9420 gttcgaactg gtaacaggag tactggtata agggacacta gtactggtag tacaattcgt 9480 agttgtgaga ggggtgctag tgacaggagt actggtataa gggatactag tactggtagt 9540 acaattcgta gttgtgagag gggtgctagt gacaggagta ctggtataag ggacactagt 9600 actggtagta caattcgtag ttgcgagagg ggtgctagtg acaggagtac tggtataagg 9660 gacactagta ctggtagtac aattcgtagt tgtgagagga gtgctactgc tggttggagg 9720 aacagtagga gtaaccggag tagtgctatt tccagtaggt gggatgctag tactggtagt 9780 gcagctagtg ctagttgaga gaagagggct actgctggtg ccggtactag aagtactagc 9840 aggaggaggt ggagtgctag tgcttgaagt actggttggg ggaacagtag gagtaacggg 9900 agtagtgcta tttccagtag gtgggatgct agtactggta gtgcagctag tgctagttga 9960 gggtagaggg ctgctgctgg tgccggtact agaagtacta gcaggaggag gtggagtgct 10020 agtgcttgaa gtactggttg ggggaacagt aggagtaacg ggagtagtgc tatttccagt 10080 aggtgggata ctagtactgg tagtgcagct agtgctagtt gtcggtagag ggctactgtt 10140 agtgtcggta ctagaagtac tagtaggtgg aattggaatg ctagtactgg aagtactagt 10200 aggaggaaca gtgggagtga taggagtact caagctcgag ctacctcctg tagggatact 10260 agtactagta gtgcaactag tgctagttgt cggtagaggg ctactgttag tgtcggtact 10320 agaagtacta gtaggtggaa ttggaatgct agtactggaa gtactagtag gaggaacagt 10380 gggagtgata ggagtactca agctcgagct acctcctgta ggtgggatac tagtactagt 10440 agtgcaacta gtgctagttg tcggtagagg gttactgtta gtgtcggtac tagaagtact 10500 agtaggtgga attggaatgc tagtactgga agtactagta ggaggaacag tgggagtgat 10560 aggagtactc aagctcgagc tacctcctgt aggtgggata ctagtactag tagtgcaact 10620 agtgctagtt gagggtagag ggctactact actgccagtc gtagaagcac tgctagtact 10680 tgaagtactt tctgtaatta tgggagtaga ggcactagta tcagttgtgc agctagtaga 10740 tgtaatttcg acgggagatc ccgtggacaa agaagcatta agatcttcgt ttctttttaa 10800 aagatcggcg taattaatgg atgttgctac aaagtcatgg tagatatctt gtacctcatt 10860 agcacttaat gaagcttcgt ttgcgagtcc gcaggatgct gctgctggag caagatgctg 10920 tgcaagcaat aaaagagtcg aaataaagaa gcgattcatt tgaggtaaaa acttcaaaaa 10980 ggtttaaaat ggtatattcg atgtcaagaa ttaaagctgg aagagaacag acaattcctt 11040 tacgatataa aaaaaaggga agaatgcttc acaggttgaa attaaatcga ttcaataact 11100 cttttaaaga ttgtaaacgg tgtggaaaga atgaatacaa aagatattaa agaaacgatc 11160 aaaagtaatt acggatataa agaaagaagc aatccgaaaa ataaaccagc gttctactaa 11220 taatgagaaa gctgtatatg ttaaagaccg aaaattttcc aaaaaaattc aaaaatgaag 11280 gcgaacacac gaggaaaaag aataatgaat ggaaccaagt gctaaagatt aaaaaattgt 11340 gacgagtaaa gaaagcaaaa cttttcacag aaaaatatgt ctgtattaaa agttgtcaca 11400 gaattaggat tatctgccaa caattatcga aattaacatt cacggagttt gtccaaaaac 11460 caatgttttc caaagcagac gaagtgctat gggtctattg aatataaaag attggatgga 11520 ttgcaaatat aagtaaacaa tcgattaaag atattccaaa aaaaagtcca cacccaacag 11580 gactgataat tagtagctta gtagctttct actctcgttt caaacgaatt tgatcaagca 11640 gcaaagttgc acctattaaa agcacacaag tagacaacct ttctgtaatg aaaaagagta 11700 caacagcaat tgaattaatg gagtacactt caagattgtg ttaccacgag tgtatgaatc 11760 ttgactatcg tacaagttca cagaaaatct aaccaagtgt tgaaaagcaa gtgcaataag 11820 ccaaaggtaa gctaactaag ccgaaattta tcacaatggg atggaggaaa acacaccaca 11880 aaagtgcctg cgccatccgt tttaaaggtt tttctaaggc gaattcattt cataaacccc 11940 ttggacattt caaacctcaa ctatgtaatt tttgattaac cgtgtgcagt gtccctccgg 12000 gtatccagaa gttctaatga atcaaatgtt tcaaacgaac aatccacgac atcgatgaag 12060 catccgcagc gttcgtgacg acaatctcca ccctttcccg tacatttcac aggattccat 12120 tacaacgaaa agtgtttcac aggcaaaatc tgaattgcag ctacgtttat catcgacgta 12180 tatgacaggt taagtcatag tgcttctaat tttaattcaa tggcgtaaaa tcaagttgaa 12240 attttggtgg taaccggtct aaattatttt ccgccttgca atttgtaaac ccatctctaa 12300 atatagagcc cacgttgtgg gagttgattt gctaagcata tcatactgca cggttattga 12360 acacagcttc ccaatttcag tggacagaga tcaagtagag gttttaaagt caaatttcat 12420 acagacaaaa aggtcaagat acttagctta aaatcggata tatggctacc attagaggaa 12480 tcacacatca ttactaaatt tttcatatat aggagaaata aatggacatt gaattactgt 12540 tgtagctgta ggcaataccc cacaaaatcc ttactagaaa aaaagaaagg aaaagagaaa 12600 ccccaaaaca aattgtagaa cggaaaagcc aggacatact taccaattcg ttttgggaat 12660 gaataactaa atatatcaat aacacagggc ttaaaatact taccggggat aaatgcatgc 12720 tcaggatcaa tggtctaaaa atattgcaag ggggttgact gattacttca ttcatcctcc 12780 tgtccacatt ccacccgaaa aagtaagaag agataaaacg gctgaggcca aacaccgatt 12840 ctatagatac atgacataaa acccccgtag cagaaaacac ccaaccagaa aacaaaattc 12900 aaagtcaaca atcaccaaca tgaaggcgta actaaaaata atggaaacaa ataagacatg 12960 aacctaaaat gcaagatgca aagaggctgc atcaattttg atatcaaaag cgaccgaagc 13020 tgcccatgat acgttttcaa ataaaattca gaatggacac aaaaagtatt tattctttac 13080 attccaaatc accttaagca accaacaaaa ttaccgcggc aatcatcaat ccattcaatc 13140 ccattgatac gctggctttt gaggaggcgg ccgacgtcgt actagagctg gatgaggagc 13200 tagaagtgta agaagtgctg cttgaagtag aagcagtctt tacatcgtca tcagaaccag 13260 atgtggcggt agtgttgctg acagtttgga aaccagagct caagtacgta gatgtgaagg 13320 tggtgggatc gatagtagta aggtcaccgg tggtaattgt tacgttgcca gtaatggtag 13380 cggtaacatt cgatacaatg gtggagttgc tactgttcca gatagaagtg gtgttcatac 13440 cttgagtagt gttgctataa ctaggatatc ctgagccacc tggacctggg gtaaagctag 13500 tagtaggagg agcgctaaca ctgctacttg ggttacctgg gttaacaggg atgatggtgg 13560 tagtaccgcc gattatggta gtagtgaagg agaaggtact ggtgaatgtg gtaggctcag 13620 tgtaagtagc agtaccctcg gtcgtttcag ttccggtagt aacggttggt tcgttggtag 13680 gagcagctgt tgggttaccg ccgccagttc cacttgcagt ggtgggttca atggtagaag 13740 ttataatctc agtagtttca aatgtcgaag tttcagtaac ttcggtaaca ccagtcgtgg 13800 ttccagtacc ggtggaagta acggagcttc cagtactagt ggtaggaacg acactgccct 13860 gagaggaact tccagtggga cgagtaccgg ttgcagaacc agaagtagaa ccaaaggttt 13920 cagtagggat gatgctgcta gtcaaagtag agctcaatct gctaaaggta gaagatccac 13980 ttgaaggata agcgctagaa ttgctcaaag gagtggaaac actgctagtg ggtaagccgg 14040 atgtagtatt gaaaccagag gaagtgaagg tgctagtagg agcaacggt 14089 //