ID SPAC637 standard; DNA; FUN; 35905 BP. XX AC AL034583; XX SV AL034583.1 XX DT 22-DEC-1998 (Rel. 58, Created) DT 26-JAN-2000 (Rel. 62, Last updated, Version 2) XX DE S.pombe chromosome I cosmid c637. XX KW eifIII; elongation initation factor III subunit; exonuclease; KW galactosyltransferase; histone acetyl transferase; meiotic development; KW microtubule-associated coiled-coil protein; KW mitochondrial atp-dependent rna helicase; nucleotide binding protein; ssm4; KW tetratricopeptide repeat; TPR domain protein; tpr1; KW ubiquitin fusion degradation protein; vacuolar atp synthase subunit b; KW vma2; zds family proteins. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-35905 RA Purnelle B., Goffeau A., Wood V., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (21-DEC-1998) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk and Unite de Biochimie Physiologique, Universite RL Catholique de Louvain, Place Croix du Sud 2/20, B-1348 Louvain-la-Neuve, RL Belgium XX DR GOA; O42667; O42667. DR GOA; O42668; O42668. DR GOA; O94236; O94236. DR GOA; O94442; O94442. DR GOA; O94443; O94443. DR GOA; O94444; O94444. DR GOA; O94445; O94445. DR GOA; O94446; O94446. DR GOA; P31411; P31411. DR GOA; Q10435; Q10435. DR SPTREMBL; O14100; O14100. DR SPTREMBL; O94440; O94440. DR SPTREMBL; O94441; O94441. DR SPTREMBL; O94442; O94442. DR SPTREMBL; O94443; O94443. DR SPTREMBL; O94445; O94445. DR SPTREMBL; O94446; O94446. DR SPTREMBL; O94447; O94447. DR SPTREMBL; P78817; P78817. DR SWISS-PROT; O42667; SSM4_SCHPO. DR SWISS-PROT; O42668; TPR1_SCHPO. DR SWISS-PROT; O94236; IF37_SCHPO. DR SWISS-PROT; O94444; RPNA_SCHPO. DR SWISS-PROT; P31411; VATB_SCHPO. DR SWISS-PROT; Q10435; YDE1_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c637 overlaps cosmid c27D7 and cosmid c31F12. XX FH Key Location/Qualifiers FH FT source 1..35905 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c637" FT /map="IR" FT CDS complement(1..889) FT /db_xref="GOA:O42667" FT /db_xref="SWISS-PROT:O42667" FT /label=ssm4 FT /note="SPAC637.01c, " FT /partial FT /gene="ssm4" FT /gene="SPAC637.01c" FT /product="microtubule-associated coiled-coil protein" FT /gene="SPAC27D7.13c" FT /protein_id="CAA22580.1" FT /translation="MSYLSVGDEVLIRGELGIVRFAGSTDFESGIWLGVELLNGKGKND FT GSVKGKRYFSCEKGKGIFVRACSSNVMKRPSVVKSRKKGSENISNFMEKTKAIKQKSRR FT EPSKFERSLARPLCITPIDSSTPTKTATFYTSSTTENLDELNFSTEELSSFDTTLLNSD FT TSKLSGLDDSSFMEEEFVWQVDNVLQECEKKFTPHSKGSYLKENLKSELRKGRLDELMC FT ENTALKEKIDKLNKELEKVEPQLTFLRSKNSIEKPRNFRREKFLKKFLAMQKEIKYLRK FT RKLQIRKIPNYKYSD" FT misc_feature 1..5489 FT /note="nominal overlap with cosmid SPAC27D7, EM:AL009227 S. FT pombe chromosome 1" FT misc_feature complement(695..823) FT /note="Match to PF01302 CAP_GLY, CAP-Gly domain Score FT 86.29" FT CDS complement(1338..4457) FT /db_xref="GOA:O42668" FT /db_xref="SWISS-PROT:O42668" FT /label=tpr1 FT /note="SPAC637.02c, len:1039, related protein in yeast asso FT ciated with G1 cyclin activation" FT /note="SPAC637.02c, len:1038" FT /gene="tpr1" FT /gene="SPAC637.02c" FT /product="tetratricopeptide repeat protein" FT /gene="SPAC27D7.14c" FT /protein_id="CAA22581.1" FT /translation="MEGFTLETHASRIIEVPLLGQEDQSVEIDCSSLPSDATELCEILV FT NEQAPREFWTKFAHEYYIRGLREQAILILKSGLETLKDSESLCILNANIAAIYLSMARE FT AMLKKDTDLRDEQLRNVRTYLEAANNIDSKSEINVLLHGIYRILLNPTDKESLENAARC FT FDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFKPDPRIGIGLCFWN FT LDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDLAFQNVNNDSFVQNYGKALQHIQRA FT FKTRNNDPVASSILERYVYSKKNYEGCIKLAENVIQNSFSSSLIADGYYWMGRAYHQMG FT NNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVV FT LGCLHASDSKPDLTKARMLLDRAFNLVGSSKLPRVVDSDLYITQARLWEKEDTKKSLGF FT LTRALDFLESAHMSVGPELLNNIAVLQYHLGLIPEAHGNIIKAKSVLPDANPELSLLLD FT YNLARCEEELGNTSVASEAYVSILEKHPSFIDARIRKCLLQLSNPNEETFKEIRHIMNA FT DSQNLEVRAFFGWYLSKQKRRPVEDPEVRHCSQTLRHWHDDIYSLVQLGNAYMRQAREF FT RVHNDREKLKRQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKV FT REAIKDATTLINIGNCLAELKQFSRAIEVFETVYSSTGESDTYGVLSCLGRVWLQRGRE FT SKNVDYLKESVRYATLALEKNPENPSLLFNVAFVQFQLCELIRQKPENSRTVEDLNFAM FT QQLDASIETFTKLVSVEHPPYSPTSIEQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKL FT EDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWRKSQQKASEDDMS FT LSDDEEKQSGKKKKKDRKKRKSKSKQESSDSGVSEDDEIPLSDARNKTKKRRVNRRVIS FT EEYTFDQDSDAEGNQEEEVSRTIEEKQDNDITDNQDDNKELNLFSEEDEE" FT misc_feature complement(3390..3473) FT /note="Match to PF00515 TPR, TPR Domain Score 23.01" FT misc_feature complement(3840..3926) FT /note="Pfam match to entry PF00515 TPR, TPR Domain" FT CDS 6757..7566 FT /db_xref="SPTREMBL:O94440" FT /label=SPAC637.03 FT /note="SPAC637.03, len:269" FT /gene="SPAC637.03" FT /product="hypothetical protein" FT /protein_id="CAA22582.1" FT /translation="MQITRESKYIIGLVLALGVSFATLLAHLFTKPSLEWVYNHHATPF FT FANKFMLGGYLLVEYLSFLLMIVPLLMLGDQVNDFTFSIIHTSIWYNVFVVFTVWAFTR FT EKLYWTAFFSLCLFSSSFTMYGQSLRLRNGFVEMISMKLPSKLVFGKSLWFVVYAFSAA FT LHCTGIGCRVFSNVFIWFFAAMYLVPILGFHDWALSLVSAYLFLSIGIGQMFIHLFALQ FT HIFAFIIAGLMTLFAALLFLLPYRQRRAALTGESAPLLQDNNAGPAV" FT CDS join(8277..8285,8325..8436,8493..10960) FT /db_xref="SPTREMBL:O94441" FT /label=SPAC637.04 FT /note="SPAC637.04, len:862" FT /gene="SPAC637.04" FT /product="hypothetical protein; possible coiled-coil" FT /protein_id="CAA22583.1" FT /translation="MFSAKAKTYELKLEQTRCNGDWQAIPEVARKLHKHNSSKSFVCEL FT AKIEASLKSALTAELKNIANVLEPKLIDNQYSLIPALPSARTDPLLSQLNSLNIQNATE FT DEKLQETSIRLLLYIVQRKFPEAVDLDWSPQGIPWTETSTGICILQATVLSSLAQYAQA FT NDEVAYQYVRSAIGLIQNANIGKKPLPELTRWCDLAYSLYAQMSVSACSSQLERANILT FT TCLSYFTEHKSVNLLYKLVTSRQAIKYLEHILRTNTNGSKIFTKSPVKNLYLNWPQLVL FT DYGSLLCNFTSFPKAGDQNMFAVEFIELATSIWINTEKSYDITVSLIRMLYQLTGKCFQ FT AQQIFRSLVFFLRHIEEFEEASEAFEIYKFLCVKSHERLARKNSDVAGSFSDIKPVFVD FT EPKSIIEVCSVMMTVYAQYLRNLKKVSEILDYITKIASDYDLLKRDDIAPLIYHTEGVA FT YSFMYYQANNPSLRERYHQKSVQSYQKCLEKQPTNTNALFHLAMQYSERRAITDAMQIV FT RRLLEVNPKYSIVSWHLLVLCVSCSEQYAAGIKLIDSVFETWGINHVNEDGTIEISLTN FT LTFNDRCALVDLLITKLALFEAEKGVEATLDIQDEIFTLFASIFDLNEYRISKEGSSDE FT LSTLLERSTIQSIKSSKKISKDVENEKGSILGFSRKSSLKRSTVLSKKSHSSYKENFQL FT RRGKTVSYLNQKLWLTAASLFLKSGNDDQARSALLEAKKIDHECAWVYYLNGLSLLQQG FT KEVEGYEQLDVAHYLDPEDPLISTALAKCLLQGGYGPMHSRRNRADAILSSCTLQYGWD FT LPEAWYYTAEIFRQLGDLKQAAFSYDYCIQLADTNPVRRWSNLQPRFMNV" FT misc_feature 8286..8291 FT /note="gtacgt, splice donor sequence" FT misc_feature 8312..8324 FT /note="ctgactgatatag, splice branch and acceptor" FT misc_feature 8437..8442 FT /note="gtgagt, splice donor sequence" FT misc_feature 8478..8492 FT /note="ctaacctttttttag, splice branch and acceptor" FT CDS join(complement(12991..13031),complement(12878..12949), FT complement(12771..12819),complement(11828..12677), FT complement(11283..11782)) FT /db_xref="GOA:P31411" FT /db_xref="SWISS-PROT:P31411" FT /label=vma2 FT /note="SPAC637.05c, len:503" FT /gene="vma2" FT /gene="SPAC637.05c" FT /product="vacuolar atp synthase subunit b" FT /protein_id="CAA22584.1" FT /translation="MASLFDINAAAAVKDYSIKPRLSYNTVNSITGPLVILDNIRRPQY FT NEIVNLNLPDGSVRSGQVLEVAGHKAIVQVFEGTSGVDVRKTTIDFTGHSMRIPVSEDM FT LGRVFNGSGLPIDKGPNLLAEDYLDINGSPINPYARIYPEEMIQTGISSIDGLNSIARG FT QKIPIFSAAGLPHNEIAAQICRQAGLVKRPTKDVHDGHEDNFSIVFAAMGVNLETARFF FT QRDFEENGSFERVTLFLNLANDPTIERIITPRLALSASEFLAYQTEKHVLTILTDMTSY FT ADALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDDIT FT HPIPDLTGYITEGQIFVDRQLHNNAIYPPINVLPSLSRLMKSAIGEGMTRNDHGDVSNQ FT LYAMYAIGRDAASMKSVVGEEALSQEDRLALEFLGKFEKTFISQGAYENRTIFETLDLA FT WSLLRIFPREMLTRIPKKILDQYYSRSSAYTESSKDVIDNTPESS" FT misc_feature complement(11361..11642) FT /note="Match to PF01038 ATP_synt_B_c, ATP synthase beta FT chain, carboxyl terminus Score 215.49" FT misc_feature join(complement(11828..12677),complement(11661..11782)) FT /note="Match to PF00006 ATP-synt_ab, ATP synthase alpha and FT beta subunits Score 440.93" FT misc_feature complement(11783..11797) FT /note="ctaattttttcttag, splice branch and acceptor" FT misc_feature complement(11822..11827) FT /note="gtatgt, splice donor sequence" FT misc_feature complement(12678..12688) FT /note="ctaattaatag, splice branch and acceptor" FT intron complement(12678..12770) FT /note="confirmed intron" FT misc_feature complement(12765..12770) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(12820..12834) FT /note="ctaactctgctatag, splice branch and acceptor" FT intron complement(12820..12877) FT /note="confirmed intron" FT misc_feature complement(12872..12877) FT /note="gtacgt, splice donor sequence" FT misc_feature complement(12950..12961) FT /note="ttaacaatttag, splice branch and acceptor" FT intron complement(12950..12990) FT /note="confirmed intron" FT misc_feature complement(12985..12990) FT /note="gtaagt, splice donor sequence" FT CDS 14129..15172 FT /db_xref="SPTREMBL:P78817" FT /label=SPAC637.06 FT /note="SPAC637.06, len:346, SIMILARITY:Saccharomyces FT cerevisiae, MN10_YEAST, galactosyltransferase mnn10, (393 FT aa), fasta scores: opt: 1031, E():0, (49.3% identity in 272 FT aa)" FT /gene="SPAC637.06" FT /product="putative galactosyltransferase" FT /protein_id="CAA22585.1" FT /translation="MWNPKKKSEALAKFKSFPYPKPGTSNVLDSKEGDTRRKYFTKTHL FT HRLFVFVVLLLCSGYFLKHTLLTRPKESNVVMIFVNNIGGGVLDVKSPRQWELEKISTE FT NKKKYAERHGYHFFVKSTGLKRRYAHEWRESWEKADYIMEAMKKYPHAEWFWWVDLTTF FT IMEPQYSLEKLIINRLDHIATRNITDSMEFNPKNFHEIPFVDYSEDINFILGQDCNGFS FT LGSFLVRRSDWTSRLMDFLWDPVVYGQKHMDWPHDEQNAIEYFYENNAWLRSGMGFVPL FT RLFNSYPPGACAGEGENPRFFYNQKEGDFLVNLAGCNYGRDCLDEINHYKGLAQRKRGW FT RKLVPFL" FT CDS 16054..17757 FT /db_xref="GOA:O94236" FT /db_xref="SWISS-PROT:O94236" FT /label=moe1 FT /note="SPAC637.07, len:566" FT /gene="SPAC637.07" FT /gene="moe1" FT /product="elongation initation factor subunit; negative FT regulator moe1.; microtubule destabilising protein" FT /protein_id="CAA22586.1" FT /translation="MATGFKLPELAPVKSAWGPPETEQIGGDIPYAPFSKGDRLGKIAD FT WSVDQPKDGREQRGRQGAFAGRFRDQYQTYGYGASSIFGYQHSEDESSFSVIDRGSVNR FT TRTSARNGGTLLKVRGRGQNVQRGGRGGRYGSSGGRGAGDTVVSRSSGAGGARGRRFGW FT KDYDKHQRLRNASVTVGDDWQLLDEVEFSHLSKLNLAAAAPVTVDSYGYIYPYDKSFDK FT IHVKSEKPLQALDRVHYNPTTTEDPVIQKLALNSDANIFITDSILSLLMCSTRSVYPWD FT IVITHQSGKLFFDKREGGPFDYLTVNENAYDSPMDADNREGVNSPGALSVEATYINQNF FT CVQALRETEEEKYKLPHPNPFYNSKEESEPLAAHGYIYRDVDLSLETDEKPVKLMVRTE FT VDGYVKNPANDVQYISIKALNEYDPKFTNVTGSVDWRSKLESQRGAVFATEMKNNSCKL FT ARWTVEALLAGVDSMKVGFVSRSNARDAQHHGILGVVAYKPADLASQMNLSLSNGWGIV FT RTIADVCLKMPDGKYVLVKDPNRPILRLYSVPPNTFEEAAGPSLEASSTA" FT CDS 18318..19271 FT /db_xref="GOA:O94442" FT /db_xref="SPTREMBL:O94442" FT /label=SPAC637.08 FT /note="SPAC637.08, len:316, SIMILARITY:Saccharomyces FT cerevisiae, NB35_YEAST, nbp35 protein.nbp35 protein., (328 FT aa), fasta scores: opt: 1437, E():0, (62.9% identity in 302 FT aa)" FT /gene="SPAC637.08" FT /product="putative nucleotide binding protein" FT /protein_id="CAA22587.1" FT /translation="MQIQETVPLDAPEHCPGPSSENAGTASACEGCPNQQICASAPRGE FT DPDLPLVVERLKEIKHKILVLSGKGGVGKSTFSSQLAWGLSLEEDKQIGLMDVDICGPS FT IPRIMGVEKEEAHQSSKGWSPIYVCPNLAVMSIGFLLPSEDSSVIWRGPKKNGLIKQFI FT KDVNWENLDYLIVDTPPGTSDEHLSLVQFFKNSGIDGAVVVTTPQEVALQDVRKEIDFC FT RKASIPILGLVENMSGFVCPSCKGKSNIFTITTGGGEALAKEMGLPFLGKIPLDPLIAR FT SCDFGKSFIDECPESPASEIIIDIINKIDESLQKRQ" FT misc_feature 18519..18542 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 18819..18869 FT /note="PS01215 Mrp family signature" FT CDS 19626..21497 FT /db_xref="GOA:O94443" FT /db_xref="SPTREMBL:O94443" FT /label=SPAC637.09 FT /note="SPAC637.09, len:622, SIMILARITY:Saccharomyces FT cerevisiae, YG5S_YEAST, hypothetical 62.8 kd protein in FT taf145-yor1 intergenic region., (553 aa), fasta scores: FT opt: 613, E():1.2e-30, (29.6% identity in 587 aa)" FT /gene="SPAC637.09" FT /product="putative exonuclease" FT /protein_id="CAA22588.1" FT /translation="MGELQDGITQEDSIEKKSKNVASHGEKRKVKRKKEDLSMDGSNDG FT VKDSPDSNDDSQSKKKKKKKLKKSQQPLNEENYPRLQTTENNLQKPLKISDLQELVFWC FT LADGQAPSWVLVRNKQMIHRAVILLVPGLEPSQFGFQPVRGNKHSFLLPNLLNENGPIQ FT LPDFCEVFDRAWPTRSPGDRFRVFSPVNAFLQSPLSNEQKKKRDKETRAMASFSKPSDY FT LMSYESFIEDEYPLHPTVMKGEEVTQPSGWVASAGDFHSPPINPKILAIDCEMVRTENG FT LEIARVTIVDMKSEVIYDEFVKPESPVTDYVTQYSGITEEKLRNVTTVLSDVQSYLKKT FT VDNNTVLLGHSLNSDLNCLKFTHPHIIDTANIYNHTRGPPSKPSLKWLATKWLRREIQK FT AGALGHDSAEDALACVDLLKLKVKNGPAFGLFNQDFESIFHRLSRQQPTPLIGAIADYG FT NPESCIGKAAHKSVSCANDDEVVSAVVSLSDMHNFVWGRFRELEHAAMWNANRNTKQEN FT NSDTDTENDSVEEDQVTSYSSALERFNRRIRLLYDSLPKGSLLLLYTGTGNPIEMSKLN FT AIRQQFRKEYQTKKWDELSVKWTDEENMKYISAVENTRNGLSFMTIK" FT misc_feature 20433..20912 FT /note="Match to PF00929 Exonuclease, Exonuclease Score FT 73.61" FT CDS join(complement(22814..22839),complement(22625..22771), FT complement(22222..22545),complement(21924..22158)) FT /db_xref="GOA:O94444" FT /db_xref="SWISS-PROT:O94444" FT /label=SPAC637.10c FT /note="SPAC637.10c, len:242, SIMILARITY:Mus musculus, FT PSD4_MOUSE, 26s proteasome regulatory subunit s5a, (376 FT aa), fasta scores: opt: 716, E():0, (46.9% identity in 241 FT aa)" FT /gene="SPAC637.10c" FT /product="26s proteasome regulatory subunit; s5a" FT /protein_id="CAA22589.1" FT /translation="MVLEATMILIDNSEWMINGDYIPTRFEAQKDTVHMIFNQKINDNP FT ENMCGLMTIGDNSPQVLSTLTRDYGKFLSAMHDLPVRGNAKFGDGIQIAQLALKHRENK FT IQRQRIVAFVGSPIVEDEKNLIRLAKRMKKNNVAIDIIHIGELQNESALQHFIDAANSS FT DSCHLVSIPPSPQLLSDLVNQSPIGQGVVASQNQFEYGVDPNLDVELALALELSMAEER FT ARQEVAAQKSSEETEDKKMQE" FT misc_feature complement(22159..22171) FT /note="ttaacaattttag, splice branch and acceptor" FT misc_feature complement(22216..22221) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(22546..22558) FT /note="ctaatcatattag, splice branch and acceptor" FT misc_feature complement(22619..22624) FT /note="gtatat, splice donor sequence" FT misc_feature complement(22772..22783) FT /note="ctaacatggcag, splice branch and acceptor" FT misc_feature complement(22808..22813) FT /note="gtaaga, splice donor sequence" FT CDS 23496..25439 FT /db_xref="GOA:O94445" FT /db_xref="SPTREMBL:O94445" FT /label=SPAC637.11 FT /note="SPAC637.11, len:647, SIMILARITY:Saccharomyces cerevi FT siae, YPL029W, SUV3_YEAST, mitochondrial atp-dependent rna FT helicase suv3 precursor, (737 aa), fasta scores: opt: 1222, FT E():0, (39.8% identity in 553 aa)" FT /note="SPAC637.11, len:646, SIMILARITY:Saccharomyces FT cerevisiae, SUV3_YEAST, mitochondrial atp-dependent rna FT helicase suv3 precursor., (737 aa), fasta scores: opt: FT 1222, E():0, (39.8% identity in 553 aa)" FT /gene="SPAC637.11" FT /product="mitochondrial atp-dependent rna helicase suv3 FT precursor." FT /protein_id="CAA22590.1" FT /translation="MFLETLIHGVTFCVPFFSKSARIHTLSKDVFQQRKFPGNTLWAAA FT LNRFTAYLFASKELSSKQAYLAQDFVNVCKDASVFQNVYYYELKKNILTDLGFSDLKNS FT DKSLALSKSSSTFDLQKIKKIHDCLLSEYRKYVRYQERIEETRPDLQKQLTDLKNPIEW FT YPGARKLRRHIIMHVGPTNSGKTHRALERLKTCKKGIFAGPLRLLAHEIYNRLQANGIA FT CNLYTGEEIRNDYPFPQVVSCTVEMCNLSTTFDVAVIDEIQMMADPSRGYAWTQCLLGL FT QAKEIHLCGEESVVKLVRSIAKMTQDDFTVYRYERLNPLHVAEKSLNGKLSELKDGDCV FT VAFSRKNIFTLKSKIDQALGKKSAVIYGSLPPEVRNQQASLFNSKSSDENILLASDAIG FT MGLNLGVKRIVFSDLKKFSGVSTIDIPVPQIKQIAGRAGRHNPNGSKQSAGIVTTLYQK FT DFAKLNRAMNLPTKNLFNACIGAKDDLFFRYLSLFSDDIPQKLIFDRYFKLAKTTTPFV FT VSEGALSTFIIEYLDHIKGLTIKDKIKLLGCPVLKHSKYAPLFIREIGCVIAQGKRLQI FT YDLKSVPLEILERGIPTTETELQQLEQLHKLIVAYMWASIRYPAILQNGAAEKTKAIAE FT AFLIKGISKLQK" FT misc_feature 24030..24053 FT /note="PS00017 ATP/GTP-binding site motif" FT misc_feature 24564..24818 FT /note="Match to PF00271 helicase_C, Helicases conserved FT C-terminal domain Score 43.76" FT CDS complement(25587..26978) FT /db_xref="GOA:O94446" FT /db_xref="SPTREMBL:O94446" FT /label=SPAC637.12c FT /note="SPAC637.12c, len:462, SIMILARITY:Saccharomyces FT cerevisiae, ESA1_YEAST, esa1 protein., (445 aa), fasta FT scores: opt: 1548, E():0, (56.7% identity in 466 aa)" FT /gene="SPAC637.12c" FT /product="putative histone acetyl transferase" FT /protein_id="CAA22591.1" FT /translation="MSNDVDDESKIETKSYEAKDIVYKSKVFAFKDGEYRKAEILMIQK FT RTRGVVYYVHYNDYNKRLDEWITIDNIDLSKGIEYPPPEKPKKAHGKGKSSKRPKAVDR FT RRSITAPSKTEPSTPSTEKPEPSTPSGESDHGSNAGNESLPLLEEDHKPESLSKEQEVE FT RLRFSGSMVQNPHEIARIRNINKICIGDHEIEPWYFSPYPKEFSEVDIVYICSFCFCYY FT GSERQFQRHREKCTLQHPPGNEIYRDDYISFFEIDGRKQRTWCRNICLLSKLFLDHKML FT YYDVDPFLFYCMCRRDEYGCHLVGYFSKEKESSENYNLACILTLPQYQRHGYGKLLIQF FT SYELTKREHKHGSPEKPLSDLGLISYRAYWAEQIINLVLGMRTETTIDELANKTSMTTN FT DVLHTLQALNMLKYYKGQFIICISDGIEQQYERLKNKKRRRINGDLLADWQPPVFHPSQ FT LRFGW" FT CDS complement(28097..29593) FT /db_xref="SPTREMBL:O94447" FT /label=SPAC637.13c FT /note="SPAC637.13c, len:497, SIMILARITY:Saccharomyces FT cerevisiae, YNE7_YEAST, hypothetical 74.8 kd protein in FT alg11-yip3 intergenic region., (656 aa), fasta scores: opt: FT 347, E():9.6e-15, (21.4% identity in 491 aa)" FT /gene="SPAC637.13c" FT /product="hypothetical protein" FT /protein_id="CAA22592.1" FT /translation="MELSGKSEFPTRTEIPNQASNGDAVPNTDAYMGLCNSLTYRFEGW FT RHLVENLIAFFKQLESTSKNNAKEYMKLSKVIVHPYKDANVFEEHGIQDIFAALRDQTA FT AIASDSEQISIQLPGTIINILELLREDLREHCKKIAAEGTKGVKVVEKQRAETQKYLSL FT LDRALLPWRASSPPTVNIKNDPFIVDRQVLNCLARQVQEENNHSVAVAQLQEFSFRFEQ FT NLIAKIKDTVKQFEGMMNQTHVKAINHLQEVVRVSEAQTLAGEWTGYAKREPEFIHGSV FT PPRSVDAIKYPGKNDQPTVPIMAGYLIRKTSFLKKKQRGFYAFTHSGYLYEFKSSDSLQ FT DPEPEFALYIPDCLIGRPSEKKPKFKITGKDATKKIFGARNDYAFRASNNTELMRWWEA FT LNTHIANVNYIQPLSNANGPSAVSDSDDDDDDPNDFRPAVERQSSTMNTRMSQPSSAVN FT TNRSYGSEQIPSYADSQGNSGANNNFIYNASATGHNAWNV" FT CDS 31510..34326 FT /db_xref="SPTREMBL:O14100" FT /label=SPAC637.14 FT /note="SPAC637.14, len:937, SIMILARITY:Saccharomyces FT cerevisiae, ZDS1_YEAST, zds1 protein, (915 aa), fasta FT scores: opt: 294, E():2.6e-07, (21.8% identity in 858 aa)" FT /gene="SPAC637.14" FT /gene="SPAC31F12.01" FT /product="related to yeast zds family proteins" FT /protein_id="CAA22593.1" FT /translation="MSSSSVSNTLSIETKSDPKDPAFVASQESTECNEHDTTQLSGSSS FT EPLENNSSLTRSTDDPSVEIRSKLVSPDNEANLLSDQNITISNENNNENDTTEEAETSS FT GNEAADDEDSSSDAQSSVPSFSEIHDGMSEEELDKERKTLTHLRRISLQGADDPEIPTD FT WSVAMSPPETEQDASTLFWVPANLHPELNPTGWKSFLDLQVKNLKSPTATDTSSSPLEH FT IRSLRRRKSLLSRQVKADDAVINYQDGSPIVEKAYLKRHRSLRLNELEHLESLARDPHR FT MVSLVDGMSNGSPEDSPLLVSPNHFLQRSSRTTIRRTGASIRTIHRGKTSTLSGNRSHS FT ILQKPTDTSPLHKIEPISADELVESDDSRTSALSNSQNPSDDVENQSDQALEVLSLTNP FT PKIDNASADTTLHKETNKIDKLYVSENKAESAVASESSLSEGTLALKAPAPENKPEKSS FT TSKPPVPENKAEDSVVLKSSVPEDKSENSIASKPSATEGIPENAIALQSSVPENKAEDS FT VVLKSSVPEDKSEDSVPSKSSVLEDKHENSVEIDKKADDSLPSNNKTEGYTPSVVREEK FT NYSEPNASPSVIPPRVPTPVPGRTLSPKPTRIPTPIPSSLNVSLESSKKPEIFHERHIP FT TPETGPNKPSKNNILKSTQVPVTPKQKSSTANKGSTSSPSPPSSESKKTKRSWGRLFVS FT GDSDKEHKEHKKDKQKKKNDQISSSSKSASSFKKDRDKESIFGSLFGSKKKQTEIPPVS FT SSPPHNDAPPKAKPISAPSELPNTTSVAEAKCQTVTDDEGTDQQSDEKSTEPKTFIPDK FT DYYWSRFPICTERAIYRLSHIKLSNAHRPLFQQVLLSNFMYSYLDLISRISSNRPMNNV FT QQSTAKPIRKDINGQQRRSEFSAENVKNELENLSYQFGDQRKRNLNRKGSTIHTVSQNI FT QKVSKNAK" FT misc_feature 31978..35905 FT /note="nominal overlap with cosmid SPAC31F12, EM:Z99166 S. FT pombe chromosome 1 " FT CDS complement(34701..35905) FT /codon_start=3 FT /db_xref="GOA:Q10435" FT /db_xref="SWISS-PROT:Q10435" FT /label=SPAC637.15c FT /note="SPAC637.15c, SIMILARITY:Saccharomyces cerevisiae, FT UFD4_YEAST, ubiquitin fusion degradation protein 4, (1483 FT aa), fasta scores: opt: 826, E():0, (43.5% identity in 421 FT aa)" FT /partial FT /gene="SPAC637.15c" FT /gene="SPAC31F12.02c" FT /product="putative ubiquitin fusion degradation protein" FT /gene="SPAC12B10.01c" FT /protein_id="CAA22594.1" FT /translation="SVSFLLSRNPELSKNESSSILQFVSLHRQKIRISRKKIFNYALHL FT LATYAASENILEIEYEDEVGSGLGPTLEFYTSVSKEFTLNSLDIWRNDQPNSKFVYQAS FT GLFPSPIPLLGSSPENERKISLFFALGQFVARSIYDSRIISIQFNPLFFARNIPLTISS FT VAKVDKGLANSLRYLEKLIPGKNPTNAETDIKLEDLHLDFTLPGFPSIELIPDGASTPV FT TTFNVSDYLNYVIDYTVGKGVQQQLEAFQNGFSSVFPYTSLQVLTEHELVTLFGTVDED FT WSYATLMKSIVADHGYTMESPTIQRLLTLMSQMNFQEQRDFLQFITGSRKLPIGGFAGL FT NPPLTVVRRLNEPPYVPDDYLPSVMTCVNYLKLPEYSSSEVLGSRLSKAILEGQGSFHL FT S" FT misc_feature complement(34719..35672) FT /note="Match to PF00632 HECT, HECT-domain FT (ubiquitin-transferase). Score 213.81" XX SQ Sequence 35905 BP; 11142 A; 6704 C; 6637 G; 11422 T; 0 other; gatcagagta cttataatta ggaatctttc gaatttgcaa ctttcgcttt cttagatact 60 ttatttcttt ctgcatagcc aagaattttt tgagaaactt ttcacgccta aaattccgag 120 gtttttcaat actgttttta ctgcgaagga atgtcaactg aggttcaact ttctctaatt 180 ccttatttaa tttatcaatt ttttctttta aggcggtatt ttcacacatc aattcatcca 240 aacgaccctt ccttaattct gactttaaat tctcttttaa ataacttccc tttgaatgag 300 gagtaaattt tttttcacat tcctgcaaaa cgttgtcaac ttgccataca aattcctctt 360 ccataaaact actatcgtca agcccagaca atttgctcgt atctgagttt aacaaagtag 420 tgtcaaaact tgataattct tctgttgaaa aatttagctc atctagattt tcagttgtag 480 atgaagtata aaacgtagct gtctttgtgg gagtagacga atcaataggt gtaatgcaca 540 atgggcgtgc caatgatctt tcaaattttg agggctccct acgtgatttt tgtttaattg 600 ctttagtttt ttccataaaa tttgatatgt tttctgatcc ttttttcctt gacttgacga 660 cacttggtct tttcatcaca ttcgaagagc atgcgcgtac aaatatccct tttcctttct 720 cacatgaaaa atatcgtttc ccttttacgc ttccatcatt ttttcctttt ccatttaaca 780 attctacgcc taaccaaata ccactttcaa aatcagtact accggcaaat cgaactattc 840 ctaattctcc acggatgagg acttcatccc cgacggacaa ataactcatt tgaaaaaaaa 900 gaaaggctca gaaagtactt gataaaatgg ttagaaactg tgagattagt gtggggaggg 960 gggaacaatg tttgcaatac aggcgcgcta aaatcatcac tatgttgcac agttgagcat 1020 gttaatcacc aatgttcaaa tcacttttaa cacgcatgtt aatgttattt aagtagaatg 1080 aaacgattct tgggtgaata aacctattag ttctttttga aagggtggat agaaaaaaac 1140 aaatctagtc taaaaagcgt aaatgaatga caagagcttt tgtatacaaa aaattaattt 1200 aaatgatatt attacacgag atcataaatc atatatatga cagacaacaa ataactgaag 1260 ggagaaagtt aatatgccat tgaaataaga aaattcttat ctgaacggca taattcaaac 1320 agcaatgagc ataattatta ttcttcatcc tcttcagaga atagatttaa ctctttattg 1380 tcatcttgat tgtctgtgat atcgttatcc tgcttttctt cgatagtacg agaaacctcc 1440 tcttcttgat ttccctccgc gtcactatcc tggtcaaaag tatactcttc ggatatgact 1500 cttctattaa cacgacgttt tttagtttta tttctggcat cgctcaatgg tatttcatca 1560 tcttcgctta ctccgctatc cgaggattcc tgtttcgatt tagatttacg cttttttcga 1620 tctttctttt tcttcttgcc tgactgtttt tcttcgtcat cagacaagct catatcatct 1680 tcagaagcct tctgctgact ctttctccac tccaaaactt cttcttgcat cttttgtcgc 1740 tcttcctgaa gttgcctctc acgttcttgc ttttccttaa gtaaagcttc ttcctctgcc 1800 aatcttcgag ccttctcctt ttccctttga atcctagcat cttcaagttt ggcagcaaca 1860 ctcttctcat attcgatttg cgcttgaata gcgcgctcca attgacgctt agtagtattt 1920 ttagccatct ttgcacgttg ttcaatactg gtaggagaat agggtggatg ttcgacagac 1980 accagtttgg taaaagtttc aatcgatgcg tcaagctgtt gcattgcaaa gttcagatcc 2040 tcaacagttc tactgttctc gggtttctga cggatgagct cacatagctg gaattgtaca 2100 aaggcaacgt taaataaaag gcttggattc tcgggatttt tttctaaagc taatgtagca 2160 tatcgcacgg attcttttaa atagtcgacg tttttgcttt cgcgaccacg ctgtagccaa 2220 actcggccta aacagctcaa tacaccataa gtatcacttt ctccggtact agaatacacg 2280 gtttcaaata cctcaatagc acgactgaac tgtttgagtt ctgcaaggca attgccaatg 2340 tttatgagtg ttgtagcatc cttaattgct tcacgaacct tactcaaaat aagtagagct 2400 ttagaaaatt gcctgttttg tgctaatata atggcaatac cctgggcagc gtgtgcgttt 2460 tttggatcaa atttaatagc ttgatcataa gactgaatag ctttgatgta aagtttttgc 2520 ctttttaact tttcacgatc attatgtaca cgaaactctc ttgcctgtct catataggca 2580 ttaccgagtt gaactaggga gtaaatgtca tcgtgccaat gtctaagggt ctgagagcag 2640 tgtctaactt caggatcttc tactgggcga cgcttttgtt tactcaaata ccaaccaaaa 2700 aatgctcgaa cctctaaatt ttgagaatct gcgttcatga tatgacgaat ttctttaaac 2760 gtttcctcgt taggattgga taactgaagt aaacatttgc gaatacgggc atcaataaaa 2820 gatggatgtt tttcgagaat cgaaacatac gcttcactag ctacagaagt gttacccaat 2880 tcttcttcac aacgtgcaag attgtaatcc aagagcaagc ttaattcagg attggcatct 2940 ggtaaaacgc ttttcgcctt gataatattt ccatgtgctt caggaattag gcccaaatgg 3000 tactgcaaga ctgcaatgtt gtttaacaat tcaggaccta cagacatatg agcgctttct 3060 agaaaatcca gagctctggt aagaaatccg agactttttt tggtgtcctc cttctcccac 3120 aatctagcct gggtaatata gaggtcggag tcaacaaccc gtggaagctt tgagcttccg 3180 acaaggttaa aggcccgatc gagcaacata cgagcttttg taaggtctgg cttcgaatct 3240 gaggcatgaa gacaaccgag gacgactaga gcctcaaaac aactttgatt ctgctcagca 3300 atacgttcaa acgtcaattt ggcactggtt aaatcatttt gtaaaatctg aatttgaccg 3360 attccaacgc tggacagcag atgtcgatca tctgctgctt tggccttttg ataactagcc 3420 atggcctttt cgttattacc catttgatgg taagcacgac ccatccagta atagccgtcg 3480 gcaatcaggc tagaggaaaa agaattttga ataacgttct cagccaactt gatacagcct 3540 tcataatttt ttttggaata aacatatctt tccaaaatgc tagaagcaac aggatcgttg 3600 tttctggttt taaatgctct ttgaatatgt tgtaaagctt ttccgtaatt ttggacgaaa 3660 ctgtcgttat tgacgttttg gaaagcgaga tcgtaatagt aaagtccaat ataggtatcc 3720 accactgtgt tttttggatc aagctgctgt acacgagtcc aagccgataa ggcatccgtt 3780 ttcatatcca aattccaaaa gcaaagacct ataccaatgc gaggatcggg cttgaactgt 3840 ggattggaga caagggcacg ctgataaagc tttaaggcgg aacgataatt tccttttgca 3900 tacaagattc gcgcttttcc aagaaaacca aggatgtttc ctccggattt ctgcaacaca 3960 aaatcaaagc agcgagctgc attttccaag gactccttat ctgtggggtt caataaaatt 4020 ctgtaaattc catgcagcaa gacattaatt tctgattttg agtcgatgtt gttggcagct 4080 tcgaggtatg tacgtacgtt tcgtaactgc tcgtcccgca agtctgtatc ctttttaagc 4140 atggcctctc gagccattga caaataaatg gcagcgatat tggcatttag gatgcacaga 4200 ctttctgaat ctttcagcgt ttccaaccca ctcttaagga ttaggatggc ctgttctcgt 4260 aaaccacgaa tgtagtattc gtgagcaaac ttcgtccaaa attctctggg agcttgttca 4320 ttcaccaaaa tttcacacaa ctccgtggca tcgcttggta agctagaaca atcgatttcc 4380 accgactggt cctcctgacc aagtaaagga acttcgataa ttcgcgatgc atgggtttcc 4440 aaggtaaaac cctccatctt ctacaaattg ccttttaaag aatactcaaa tctttaaaaa 4500 agcaagacaa aacaaaccgc tttgactaaa caccttggta tcagcaactg tagcggtgaa 4560 ttgaatgtgt gcggctttag cgacacgttc ctttatcgta gctttgtgag ctgaattcac 4620 agctaaagag ctaatgctag ctatcagtaa gtttcgctaa tgttatggct tgaacacgcg 4680 cgactgataa atagataagt aaggtgaaaa ccccgccccc ttcgggagaa agtgtaattt 4740 tgcacgctcg acagtagtac aataaacaat ataaggaaac tcgttagaag tctgtatttg 4800 atgattgtag aaagcaaaac aaaaagaagc acaatctaaa aactagtact tgaaagagaa 4860 aggaaagttg ttcatatata gtagtcagac aagtaattgg atcgttgaac gagttcccca 4920 ttgcttttag gagatttcga acgagggtgt cggaatgtgc tgctcggtaa acatagaaaa 4980 aacaataaaa accagtttcc cagtcaatgc agaatttgaa aactgtttgt aatgaaaata 5040 attaatcgtg tccgtaaaag cacaaccttt aacacgaaat ttgtttaatt gagaagataa 5100 gatggggttt tcgcttacat atatttagac aagcgcaaca taatagggta agtatcacag 5160 gaagaagagg aaaaattaga atacaatttt aaaatcatga caatgtaagt agtgtaagag 5220 cgaggacttc tataatattt gacagcggca attcgggaaa acatattgcc taagtctgat 5280 tttttttgaa gttcattatt ttgctcaaag gagtgtgctg aaagaaataa ataaatcagc 5340 gttaataaaa tttaatataa atgaatcaga atataagtta gatgaaaaat tcgataagta 5400 agcaatcaag cagtttaact gttcggctaa taatacacgg gcaggtttat tcctataata 5460 tctaacgggt ggtctgcatt tgatatgatc attgcaacgt tggtgtctga cagaaaaaag 5520 tcgaattctt atagatgaat tctagcattt cttcagtcag aaaaatatat cgaagactct 5580 aagtttaccc tttaaatgtg tcacttgtgg ttttcttata cggaaaagat acagaacaat 5640 ccacggctaa aggagatcct catccaacaa cccgagaaag tctatcattt ggatgaacgg 5700 atactcatcc aaaactttca agaattgtgt tttttttgct tctatcttca atgccctgta 5760 tcgaactgaa ttgcgattgt cattaatttg ccttgctatg ccataccaag ccaagctatt 5820 ttaagcaaac ggtttagttg gactccaata ataaatgctt tacaaaaaag aaatgcgatt 5880 gataaactag aacactctcc aatgtatgtc taccaattcc taaatacttt caattcgcaa 5940 cattcttatg gcctttgtgg tcgcttcaat tcggctttga aaaccgggtt aaaaggcatc 6000 gcataaattt gtatcttcca aaacagttga ttttataaaa agctcataaa taatttctca 6060 gcgcgagcaa atggtaattt ctttgaaatc agcgcctttg gaattttcat tttacgcctt 6120 attgacattc ccatcgatat acgtaacatg ttactccatg atacatggtt tcagctgatg 6180 ccaaggcatc gttgcgtaag cattacgaag gaatatgatg atggaaggag gcatgggttg 6240 ggcagtttct gcagtctgct aaatttaaat agtctgccta tatatattaa atctctcgca 6300 cttttatgac cttccctctc ccatacatat ttgcaagttt gcgtataacg ttgctttcta 6360 acacaattta cttttaatcc acttcaaaca cttggtttag cttttaaaga aaagcttagg 6420 attttgctac tgtttgttac gaggaattgt tgcagaagaa ttcaattttt ttaagtcgta 6480 tttaccaacg attttattca atttaaaaag tttgactttc ataggctgtt gcttagttta 6540 tcgtcaattc cttgcgtatt gccggaacct agttaatatc taaaaaaaca caaacaaacc 6600 aaattccaaa agtggttgaa aattgccgct tcgctacttt tactatctcc gggaaagaag 6660 acctgtaatt taattttttc ttcttcttcc aattcgtact attaatatta ccgctagttt 6720 cttcttattc tttcgcctac tacttaattg ttcaatatgc aaattactcg tgagtcaaaa 6780 tacattattg ggctcgtctt agccttgggt gtaagctttg ctaccctttt ggctcatttg 6840 tttaccaaac catctcttga atgggtttac aatcaccatg ccactccatt tttcgccaac 6900 aagttcatgc ttggtggcta cctcttggtc gaatacttgt ctttcctttt gatgattgtg 6960 ccccttttaa tgcttggtga tcaggtaaac gattttacct tctccattat tcacacatct 7020 atctggtaca atgtatttgt cgtgtttacc gtctgggcat ttacccgtga gaagctgtac 7080 tggactgcat tcttttcctt gtgtctattc tcatcttctt tcaccatgta cggccaatcg 7140 cttcgcttga gaaatggttt tgttgagatg attagcatga agttgccctc gaaacttgtt 7200 tttggcaagt ctctttggtt cgttgtttat gccttctctg ccgctttaca ctgcaccggc 7260 attggttgcc gcgtcttttc taatgtgttt atctggttct ttgccgccat gtatcttgtt 7320 cctattttag gattccatga ctgggctctt tccctcgtca gcgcatacct tttcctttca 7380 atcggtattg gacaaatgtt tattcacctc tttgccttgc aacacatttt cgcctttatc 7440 attgctggtc tcatgaccct tttcgctgct cttctcttcc tccttcccta cagacagaga 7500 cgcgctgctt taacaggcga gagtgctcct ttgcttcagg acaacaacgc gggacccgca 7560 gtttaaactc ttgtagtctt ctgcatgttg ttgctccgtt ctactaaata gtatgataat 7620 gaatttgctt aattgtatta tgttacactt aactttagta taaaaattta atttttctcc 7680 cataaatctt tcgactcaaa attcaggtgg atagcagatt aaagcatagt tttgacgatc 7740 aacttcatca tggttaatag cacccttctt agtataaagt tgcttcgtgt gctaacttta 7800 caagcacttc attgacgaag acatccagct tattcttata tggatcacga aagtgtcatc 7860 atattcaact attcgtactc tggctaactt gtacgctaat tatttaatct tatttgcttc 7920 atgtatttat taaagaaccc ttaaagcaaa aaacttggta tacactactt tttctttact 7980 tagctcaata tctcaattac tttctcatgc cgacggttac gcacctccat tcaaccttgg 8040 cctactccat atatcgaacc atcaaaattc cttcatcttg gtattcttga ggcgttaaat 8100 accttcttta aaccttttct ttttacaatt ccttcgtttt tcttgttact gtaaatatat 8160 atcaatttat ttaaagtttg cgttcaaagt tctataaacg aattttacgt tccaactact 8220 gcgtttgacc ttttttttct ctttatatat acaaatacca agttataaaa aaattcatgt 8280 tttccgtacg tctaaactat gagttttcat actgactgat ataggctaaa gcaaaaacct 8340 atgaactaaa actagaacaa acaagatgta atggagattg gcaggcaatt cctgaggttg 8400 ctagaaaatt gcataagcat aactcttcaa agtcctgtga gtgatttaca gtcaaagttt 8460 tccacttgtc atctagacta accttttttt agtcgtttgt gaattagcaa aaattgaagc 8520 ttctcttaaa tcagcattaa ctgctgaact aaaaaatatt gcaaacgttt tggagcctaa 8580 attaatagat aatcagtatt ccctaattcc ggctttaccc agtgctcgta ccgaccctct 8640 tctaagtcaa ttaaactcat tgaacattca aaatgccaca gaagatgaga agcttcagga 8700 gacatccata cgcttgttat tatacattgt acagcgtaaa tttcccgaag ccgtagattt 8760 agattggtct cctcaaggaa ttccgtggac tgaaacttcc actggtatat gcatcctaca 8820 agcaacagtg ctatcatcgc tagctcaata tgctcaagct aacgatgaag ttgcatatca 8880 atacgttcgt tcggccattg gcttaattca aaatgccaat attggcaaga agcctttacc 8940 ggaacttaca agatggtgcg atcttgcata ttcattgtat gctcaaatgt ctgtaagcgc 9000 ttgttcgagt caattagaaa gagctaatat acttactaca tgcttgagct attttaccga 9060 gcataagtcc gtgaatttgc tttataaact agttaccagc agacaagcta ttaaatattt 9120 ggaacatatt ttaagaacta atacaaatgg atcaaaaatt tttactaaaa gtccggttaa 9180 aaatctttat ttaaattggc ctcaacttgt cctcgattat gggtctttgt tatgtaactt 9240 tacctctttt cctaaagctg gtgatcaaaa catgttcgcc gttgaattta ttgaacttgc 9300 aacatcaata tggataaaca cagagaaatc ttacgatatc actgtcagct tgattcgaat 9360 gctttatcag cttactggaa aatgcttcca agcacaacaa atttttcgtt ctttggtatt 9420 ttttttaagg catattgagg aatttgaaga agctagcgag gcttttgaaa tttacaagtt 9480 tctatgcgta aaatctcacg aacggttagc aagaaaaaat tcagatgtcg ctggctcttt 9540 ttctgatatc aaaccagtgt ttgttgatga accgaaaagt attattgaag tatgctccgt 9600 tatgatgacc gtttatgcgc aatatcttcg taatttgaaa aaagtttctg aaatacttga 9660 ttatattaca aaaattgctt ctgattatga tttactgaaa cgtgacgata ttgctccttt 9720 aatttatcat acagaaggag ttgcttattc tttcatgtat tatcaagcta acaacccttc 9780 gttaagggaa agatatcacc agaagagcgt ccaatcttac cagaaatgtc tagaaaagca 9840 accaaccaat acaaatgcac ttttccattt ggctatgcaa tattcggaga gacgtgccat 9900 tactgatgca atgcaaattg ttcggcgact tcttgaggtg aaccctaagt acagtattgt 9960 atcttggcat cttttggttt tgtgtgtgtc ttgttctgaa caatacgcag caggaattaa 10020 gctgatcgat agtgtatttg aaacttgggg cattaatcat gtcaatgaag atggcactat 10080 tgagattagt ttgacaaatt tgacatttaa tgaccgctgc gctttggtcg atttattgat 10140 tacgaaacta gctctttttg aagccgaaaa aggcgtagaa gctactctgg atatccagga 10200 tgaaatattt acattatttg ctagtatttt tgatttgaat gagtacagga tatcaaagga 10260 aggatcgtca gatgaattat caacgctttt agaacgatcg actattcaat ccattaaatc 10320 atccaagaaa atctctaaag atgtggaaaa tgaaaaagga agtattcttg ggttttccag 10380 gaaatcatcg cttaagagat ctactgtttt aagcaaaaaa tcccactctt cctataaaga 10440 aaattttcag ttacgtcgtg gtaaaaccgt atcatatctc aatcagaagc tttggcttac 10500 cgctgcatct cttttcctta aaagtggaaa tgatgatcaa gcacgaagcg ctttactaga 10560 agctaaaaaa atagaccatg aatgtgcttg ggtgtactat ttaaatggtt tatctttact 10620 acaacaggga aaagaagttg aagggtatga gcaacttgac gttgctcatt atttagaccc 10680 ggaggatccc ttaatttcga cggcccttgc aaagtgtctt ttacaaggtg gctatgggcc 10740 tatgcattct cgtagaaata gagcagatgc tattttatcg agctgtactt tgcagtatgg 10800 ctgggatcta ccagaagctt ggtattatac tgcagaaata tttcgtcaac tcggtgattt 10860 aaaacaagct gcgttttcgt atgattattg catccagcta gctgatacaa accctgtacg 10920 ccgatggagt aacttgcagc ctaggtttat gaacgtttaa actgtctaca ttttttggac 10980 ttttattatt tataaattga atttacaaac tttaaggcac tttcaatagt aatttatatg 11040 tttcctttgt agtgattgta acttcaatat gaactcacat aatagacata aatagataaa 11100 tgttatttat gacattgtgt taaattaata acgaagcaat tgcaccttga atcagtatct 11160 ataacagtct tctttccaaa tcaccaacaa acaaatagca ttagataatt gcaccgaaaa 11220 taacgattca aggacatttc aaaattagcg attatttggt ctgtatttgc agcgtcaaaa 11280 aactaagagc tttcaggagt gttgtctata acatctttgg aagattcagt ataggcagag 11340 gatcttgaat aatattgatc caaaatcttc ttaggaatac gagttaacat ctcacgaggg 11400 aagatgcgaa ggagggacca agccaaatcc agtgtttcaa aaatagtacg attctcgtaa 11460 gcaccttgac taatgaaagt cttttcaaat ttacccaaaa attcaagagc aaggcgatct 11520 tcttgagaaa gggcttcctc gccaactact gatttcatgg aagcagcatc acgaccgatg 11580 gcatacattg catacagctg gttagaaaca tcaccatgat catttctagt cattccttca 11640 ccaatggcag acttcatcag acgagaaaga gagggcaaaa cattaatggg aggatatatg 11700 gcattgttgt gaagttgacg atctacgaaa atctgaccct cggtaatgta accagtcaaa 11760 tctggaatgg gatgagtaat atctaagaaa aaattagcaa ttaaaaaaaa gatttacaaa 11820 aacataccgt cattaggcat agtcaaaata ggaatttgag taattgaacc gttacgaccc 11880 tccacacgac cggcacgttc gtaaatagta gacaagtcag tatacatata accaggataa 11940 ccacgacgtc cgggaacttc ctctcgagca gctgaaactt cacgaagagc atctgcgtaa 12000 gaagtcatgt cggtaagaat agtaagaacg tgcttttcag tttgataagc caaaaattca 12060 gatgctgaaa gagcaagacg aggagtaatg atacgttcaa ttgtggggtc attggccaag 12120 ttaaggaaaa gggtaacacg ctcaaaagat ccattttctt cgaaatcacg ttggaagaaa 12180 cgggcggttt ctaaattaac acccattgct gcaaacacga tggaaaagtt atcttcatga 12240 ccatcgtgaa catctttagt aggacgtttt acaagaccgg cctgacgaca aatttgagca 12300 gcgatttcat tgtggggaag accagcagca gaaaagatag gaatcttttg accacgagca 12360 atactattta aaccatcaat cgaagatata ccagtttgaa tcatctcctc gggataaata 12420 cgggcataag gattgatagg agaaccattg atatcaagat aatcttcagc aagcaagttg 12480 ggtcctttat caattggtaa accagaacca ttgaaaacac gaccaagcat atcttctgaa 12540 acagggatac gcatggaatg accagtaaaa tcaatggtag tttttctaac atcgactcca 12600 gaagtgcctt cgaaaacttg tacaatggct ttatgacctg caacttctaa gacttgacca 12660 gaacgaacgg aaccatccta ttaattagca ttaataaagt aacgaaataa gaaacagaag 12720 acattaagaa acacatcttc caagatatat aatttctcaa gggcacttac cggtaggttt 12780 agattaacaa tctcattgta ctgaggtcta cgaatgttgc tatagcagag ttagcaataa 12840 ttcatcaaag tacggctaaa aggctcagaa aacgtactct aaaattacta gaggaccagt 12900 aatagaattt acagtattgt aagagagtcg aggttttatg gaataatccc taaattgtta 12960 atacaggcat tcgtaaaatt ttacacttac tttacagcag cagctgcatt gatatcaaag 13020 agcgacgcca tgttaacgat tttctggaga actagaggtt caggcagaag gatttcctag 13080 tcatttacga ataaggaggt ctaaaaagag gcattttctc gttgttaaca tatgcaaaac 13140 tcgtttaaca ttgtcattat tgaaacggag ctatgcacaa tttttaaata agatatagta 13200 tgaaaataac gctatttact aatagtaaaa tgctataacg aacttcgtta attcgtaaaa 13260 aattatgtaa aaccgataga ttcctcacgt atgaaacaag aaaaatgaag caagagcgat 13320 atataccagt tgaatttaat tttggtttaa aaaataaata aatttaaata tttttcaaca 13380 cttataatat agaatgaatg aataaacatt gcaagcgata tataatagcg cgtatgaaaa 13440 tacgacgaaa cacggtgttg tcatgatggc aaataacgag gattaattaa atgtcttaaa 13500 tgctgaatcg aatattagta atattgtttc atttaacaga atttcagtga tgttttatca 13560 attgttacat tagaatgatt gtttaacaat atctaatttt ttacatgccg aatccttaat 13620 tcgagttgct gccaagtttc cttctcatgg ttgtttacac ttttcctaaa acagaattgt 13680 taaattagtt ggtagctgat aattatttgt ttactaaact aaataccttc atcgtcaaac 13740 catgagaaat ctgtcagagt ctttgcaact gacatatttt atggaaaatt tctatcgcta 13800 atttatttag catatctgag tagatgaacg cgagaataaa agtgctaaaa ctttttgagt 13860 aaacaaataa ataaaattat gcaatcagaa tctacttaac tttaccgacg ttatcgcgta 13920 ctttggctat ttactcgacg acaaggctat gccagctttg atacactggg acgttacttg 13980 ctcacgactt tcgcctttgc caaacagcct agttctgtgt gaaacctcaa acggcattgc 14040 cgtagtcata ttatcattcg aaaatatata atttaaaggt taataagaag aattaacgta 14100 aacgtcgagt cttatattat attaaaaaat gtggaacccc aaaaagaagt cagaagcatt 14160 agctaagttt aaatcctttc cttaccctaa gccaggcact tccaatgtac ttgattccaa 14220 agaaggtgat actagaagga agtattttac caagacgcat ctacataggt tattcgtctt 14280 tgtggtactg ttgctctgct caggctactt tttaaagcat acactcttga cgcgtcccaa 14340 agagagtaat gttgttatga tatttgtcaa taacatcgga ggtggcgttt tagatgtaaa 14400 aagtcccaga caatgggagc tggagaagat ttcaacggag aacaagaaga aatacgctga 14460 aaggcacgga tatcatttct ttgtgaagag cacaggctta aagagacgat atgctcatga 14520 atggcgtgaa tcttgggaaa aagcagatta tatcatggaa gccatgaaga aataccctca 14580 tgctgaatgg ttttggtggg tcgatttaac aacattcatc atggaacctc aatattctct 14640 tgaaaagctt attattaaca gacttgacca tattgcgacc aggaatatta ctgatagcat 14700 ggagttcaat ccaaaaaatt tccacgaaat tccatttgtt gactatagtg aagatatcaa 14760 ctttatttta gggcaagatt gcaacggttt cagtttgggt tcttttctgg ttcgtcgaag 14820 tgattggact agcagattga tggacttcct ttgggatcca gtagtctatg ggcaaaagca 14880 catggattgg cctcacgatg agcaaaatgc aattgagtac ttctacgaga ataatgcttg 14940 gcttcgaagc ggcatgggat tcgttcctct tcgccttttc aattcatatc ctccaggtgc 15000 ttgtgctggt gaaggtgaaa atcctcgttt cttttataac caaaaagaag gagacttctt 15060 ggtaaacttg gcaggctgta attatggaag ggactgccta gatgaaataa atcattataa 15120 gggattagcg caaagaaaac ggggttggag gaagttagtt ccgtttcttt aatagagacc 15180 tcacatattt ccatcattat tattaatatt ttaaattcat actttatcat tctttttcct 15240 tgcgtgtgct aggctgtcaa tgcgatcctt tatcatgtga tgcactaaac tctctccttt 15300 gctacttagc agcttttgcg gtcatttaac actgcttaat atttggtgct ttccgttttt 15360 atacattaat ttcttcgcaa acaattgttt taataggatt agatgtgtat attttttatg 15420 cgacatgtga tgacagaaaa gagagaatgt ctgagaacct tggcgttcat ttttttcttt 15480 cttcaaaaga cagcgttgac gaaattaaaa ttttctaaaa catgcttttg tcagaaacat 15540 ttaagccttg agacaatgac tataaaggca aagtctgatg tcgtaatcag ttttaaatta 15600 tagcataaca tatcttttat ttcaatatca atttctccca ttttttaatt taataacatt 15660 tagtgctgat ataacctgct agtatgataa agtaattcta cctactatag ttttataatg 15720 tagtgagtgg ttgagatttc cacatatcgt cttctgaata ggcatgtggg ttcacaaata 15780 aagaagtagt ttgataaata cagtaacata tactaattgt taatagatgt agtttttcta 15840 caaatatagc accttgattg caaaaggaaa tgtataacat ttaacttttt cacgaaccaa 15900 aaagtatata tattacattt aagtactttt gtattacaaa taaagcttta gaacttcaaa 15960 tattaccatt gttggctttg gtgttttagc gtctcccagt tcgtttgcac actatactgg 16020 cgtccacttc gaagaaaact tcaccactcc caaatggcaa ctggatttaa attgcctgag 16080 ttagcacccg taaaatcagc atggggacct cctgaaacgg aacagatagg aggtgatatt 16140 ccttatgctc cttttagtaa aggtgaccgt cttggaaaaa ttgcagattg gtctgttgat 16200 caacctaaag atggacgtga acaacgtgga cgtcaaggag catttgctgg tcgtttccgt 16260 gaccaatatc aaacttatgg ttatggcgcg tcgtccattt ttggttatca gcattcggag 16320 gacgaatcca gtttctcggt gatcgatcgt ggttctgtca atcgtacacg cacttccgct 16380 cgcaacggcg gcactttatt gaaggttcgc ggtagaggac aaaacgttca acgaggtggt 16440 cgtggcggtc gctacggttc ttctggtgga agaggtgcag gtgatacagt ggtttctaga 16500 tcctcaggcg ctggaggagc aagaggtcgt cggtttggtt ggaaggatta tgataaacat 16560 caacgtcttc gcaacgccag tgttactgtt ggtgacgact ggcagcttct tgacgaggtt 16620 gagttcagcc atttatctaa gctcaattta gctgctgctg ctcctgttac tgtggattca 16680 tatggttata tttatcctta tgacaaatct tttgacaaga ttcatgttaa atcagaaaaa 16740 ccattacaag ccttggaccg tgttcattac aaccctacca ctactgaaga ccccgttatc 16800 caaaaactcg ctcttaatag tgatgctaac attttcatta cggattccat tttgtcttta 16860 ttgatgtgtt caactcgctc agtgtatccc tgggatattg taattactca ccaaagtgga 16920 aagctattct ttgacaaacg tgaaggcgga ccttttgatt atctcactgt caatgaaaac 16980 gcatacgatt ctcccatgga cgctgacaac cgcgaaggtg ttaattctcc tggagccctt 17040 tctgtcgaag ctacgtacat taaccaaaac ttctgcgtcc aagctttacg tgaaaccgaa 17100 gaagagaaat ataaattacc tcatcccaat cccttctata attctaagga agaaagtgag 17160 ccattggctg ctcacggtta tatctatcgg gatgttgatc tttctctcga gacagacgaa 17220 aagcctgtta agctaatggt tcgtaccgaa gttgacggtt atgttaaaaa tcctgcgaac 17280 gatgttcaat acatttctat caaggctctt aatgagtacg atcccaaatt tacaaatgtt 17340 actggttctg tggattggcg ttccaagctc gaaagtcaaa gaggtgctgt gtttgccact 17400 gaaatgaaga acaatagttg caagcttgcc cgttggactg tcgaagcttt attggctggt 17460 gttgatagca tgaaggttgg ttttgtcagt cgttcaaatg cccgtgacgc tcagcaccac 17520 ggcattttgg gtgttgtagc ttataagcct gctgatttgg cttcccaaat gaacttaagt 17580 ttgtctaatg gttggggtat tgttcgtact attgcagatg tctgtttgaa aatgcctgat 17640 ggaaaatatg tccttgtaaa ggatcccaac agacctattt tacgcttgta ctctgttcca 17700 cccaacactt ttgaagaagc tgctggaccc tcccttgaag cttcttctac tgcttaaaaa 17760 ggacggatgt agaaagttca ttaaaaaggt tacatgtata atactcaatt acatgtgcaa 17820 atctaagatc tttaaatcgg ttttatattt tcggtttctt tattttttaa tcttatgaac 17880 tgtttctcgg taaattagaa gctaagtgta aagtaatgta tttgttggaa tagtaaaaat 17940 gaagcgaagg aaaattaagt gccgtttaat tcatttggaa atatctgatt ttcgatgctt 18000 ccaacgtgat ttttttcatg aacattgctt ttaacacact ttagggtatt acggtaaaaa 18060 aattagaact cgattagtag aaaaccgata tagctcattg ccactagcca agagatcgta 18120 aaacggtttc aagcttagtc agaatattgt ggtaaaacaa gaggtaaagc ttttagcaaa 18180 aattcgtttg aagagaattt acaccggatt acacttataa tttaccatac gtggtttaca 18240 aaaatagcta ctaaaagttc actaagcacg tgaaataaag acttttacta agcatttgct 18300 ttaatattgg cttttctatg caaatccaag aaactgttcc tttagatgca ccagagcatt 18360 gccccggacc gtcatctgaa aatgcaggaa ctgcatcagc atgtgaagga tgccctaatc 18420 aacaaatttg cgcttcagca cctcgtggag aagatccaga tttaccattg gttgtagaac 18480 gcttgaaaga aatcaagcac aaaattcttg ttttatcagg taaaggaggt gttggaaagt 18540 ccacattctc ttcgcaatta gcatgggggt tatcgcttga agaagacaag cagatcgggt 18600 taatggacgt ggatatttgc gggccttcaa ttccgagaat aatgggtgtt gaaaaggagg 18660 aagcccatca atcaagcaaa ggctggtccc ctatttatgt atgccctaac ttggctgtta 18720 tgtcaattgg atttttatta ccaagcgaag attcatctgt tatatggagg gggcccaaaa 18780 aaaacgggct gatcaaacaa ttcatcaaag acgttaactg ggaaaattta gactatttga 18840 ttgttgatac tcctccggga actagcgatg aacatttatc tttggttcaa ttttttaaaa 18900 attccggaat tgatggtgct gttgtagtta ctactcctca agaggttgct cttcaagacg 18960 tccgtaaaga aatagatttt tgcagaaagg cgtccatccc tatccttgga ttagtggaga 19020 acatgagcgg ttttgtatgt ccttcttgca aaggcaagtc taatatattc actattacta 19080 caggaggagg tgaagcgtta gcaaaagaaa tgggactacc attcttgggt aaaattcctt 19140 tggacccatt gattgcacgt tcatgtgatt ttggaaaaag ctttattgat gaatgtcctg 19200 aatcgcctgc ttccgaaatt atcattgata ttattaacaa aattgatgag agtttacaga 19260 aaaggcaatg aaaaaaatat aaaaaaaggt tggaatctgc ttaatttcaa tttttttgta 19320 taatataaaa tacgtttatt caaatattta ttgaaccttc tgagtatatt ccttgtatat 19380 cctcattgag cacttaaagt aaacatgtag tcattgtgac attttttgga ttaaaaagaa 19440 atttgaaatc cttagttaat ggatataata caagacaatg ctaaagcctg caattcaaat 19500 aaaaactcgc aatcaacata agcacattag tattccgagg atctgaagat gcattgcccg 19560 cggaatagcc gaccaccata gtgataccac caaaataaaa aatgtcaaag atgggatcct 19620 caagcatggg tgaacttcag gatgggataa cccaagaaga ctccattgaa aaaaagtcaa 19680 agaatgttgc ttcacacgga gaaaaaagga aagtgaagcg aaaaaaagaa gacctaagta 19740 tggatggttc aaatgatgga gtgaaagatt caccagactc taatgacgac tctcagagta 19800 aaaaaaagaa aaagaaaaag ttaaaaaaat ctcagcaacc gctaaatgaa gaaaattacc 19860 ctagattgca aactacggaa aacaatcttc aaaaacccct aaaaattagc gacctacaag 19920 agcttgtatt ctggtgttta gctgatggac aggctccttc atgggttcta gtgagaaata 19980 aacaaatgat tcatagagca gtgatacttt tagttcctgg attggagcct agtcaatttg 20040 ggtttcaacc cgtgcgcggc aacaagcact catttttgct gccgaatttg ctaaatgaaa 20100 atggccccat tcaattacct gatttttgtg aagtgtttga tcgcgcatgg cctacgagat 20160 ctcctggaga tcgatttcgt gtcttttctc cggtgaatgc ctttttgcaa tctcctctga 20220 gtaatgaaca aaagaagaaa agagataaag aaacacgtgc tatggctagt ttttccaaac 20280 catctgatta cttaatgagt tatgaatctt tcattgaaga cgaataccca ttacatccta 20340 ctgtcatgaa gggtgaagag gttactcagc cttcaggatg ggttgcttct gcaggagatt 20400 ttcattctcc tcctataaat cccaaaattc ttgctattga ttgcgaaatg gtgcggactg 20460 agaacgggtt agaaatagcc agagtaacta ttgtagacat gaaaagtgag gttatttacg 20520 acgaatttgt aaaaccagaa tcacccgtca ctgattatgt tacccagtat tctggcataa 20580 ctgaagaaaa actgagaaat gttactactg ttctttccga tgttcaatct tacttaaaaa 20640 agactgtgga caacaatacc gttcttttag gccatagtct aaattctgat cttaattgct 20700 taaaatttac acaccctcat atcattgata cggcaaacat ttataatcac actcgtggtc 20760 ccccttcaaa accatcgctt aaatggcttg caacgaagtg gttgaggcgt gagatacaaa 20820 aagcgggagc tctggggcac gattctgcag aagatgctct tgcttgtgtg gatcttctaa 20880 agttgaaagt taagaatgga cctgcctttg ggttgtttaa ccaagacttt gagtcaatct 20940 ttcatagatt gtcacgacag cagccaactc cattgattgg tgcaattgcc gactatggta 21000 atccggagtc gtgcattggc aaagcggctc ataaaagcgt ttcttgtgcg aatgatgatg 21060 aagtcgtaag cgctgttgta agtctttcag acatgcataa cttcgtgtgg ggtcgttttc 21120 gcgaattgga gcatgcggct atgtggaacg ctaatcgaaa tacaaaacaa gaaaacaact 21180 ctgatactga tacagagaat gattcggtag aagaggacca agtaactagc tattcttctg 21240 ctttagagcg ttttaatcga agaattcgtc ttttatacga ctccttacca aaaggttctc 21300 tattgctttt gtatactggt actggaaatc ccatcgaaat gtcaaaatta aacgctattc 21360 gccaacaatt tagaaaagaa taccagacca aaaaatggga tgagctatca gtaaaatgga 21420 ctgatgaaga aaatatgaaa tatatatctg ctgttgaaaa cacaaggaat ggattgtctt 21480 ttatgacgat caaataagtg tgtttttata ttgcgatcaa gtaaattttg ggtaaagggt 21540 ctgcatttta ttggtcataa tagatagttg aagaaaacaa ttgttttggt ttatgtatat 21600 gttgaaatta agaaaggtaa acagctagtc agacacgtat attaggggcg tttttattat 21660 tggatgccac taacgctacc ttgattgtag attaatacct ttccttctag taatgtgttt 21720 ctagaatgcg ctaacctttt ctacaatgct aattacgaaa atgaaacaaa atgctgccaa 21780 tttattattt tggatatatt ttgaaaaatc atgattttta ggattcaatc taatttaaac 21840 gttgctgcat aaagcatggc tagtaaagta caagaacgtt aatttgtctt tcataaggat 21900 aaggaatcgt agacatcttc ggatcattct tgcatttttt tatcctcagt ttcttcagat 21960 gatttttgag cagcaacttc ttgacgtgct cgttcctccg ccattgaaag ttccaaggct 22020 aacgccaatt caacgtcaag attaggatcg actccatact caaattggtt ttgagaagca 22080 actacacctt gtccaatagg ggattgattt accaaatctg aaagtaactg cgggctaggt 22140 ggaatgctga caagatgact aaaattgtta atactagtaa aaaaaagaag ccaaaaatgt 22200 ccgaaaaatc cgtagactta ccaactgtca cttgaattag cagcgtcaat gaaatgctgc 22260 aaagctgatt cattctgaag ctcaccaatg tgaatgatat caatagcaac attattcttt 22320 ttcatacgct tggctagacg aataagattt ttctcgtcct caacaatagg agaacctaca 22380 aatgcaacaa ttctttgacg ttgaattttg ttttctctat gctttaaggc taactgcgca 22440 atctgtatac catcgccaaa ctttgcgttt cctcggacag gcaggtcgtg cattgcagat 22500 aagaatttac cataatctct ggttaatgta gaaagaactt ggggactaat atgattagaa 22560 tttctgtaaa gtattttata gctgaacata aagtaccgtt caagccgtaa tattaatcat 22620 atacctatta tcaccaattg tcattaaacc acacatgttc tccggattat cattgatctt 22680 ttgattgaaa atcatatgta cagtatcctt ttgagcttca aacctcgtag gtatataatc 22740 accattaatc atccattctg aattatcaat tctgccatgt tagagcaata atttaacaaa 22800 aataaattct tacagaatca tcgttgcttc taacaccatc ttgaagacct ataatttaaa 22860 acttaatgcg aagaaatttg aaagaacgct tggtagatta cagaagatgt gttgcaaagt 22920 gaactagaca aggtattact actcaccttc tctagtcatt ctcggataac gatatgtaac 22980 gcatcacaaa atgaaacatc gaaaaacatg gtgatacaca attcatttcc tgttcgaatc 23040 cacaggttct ctaatttctt acagcacgcg taaataatcg aaagccaaca ccaaatgcgt 23100 gaaattgtta taatacaagt gtaggtaata aacgcttttt aaaaaatttt atatatttac 23160 tgaagcggaa aactggaatt taaagggtac tgctgagata ctaatttttt ggagatacat 23220 gcagagctgt tggtataaca tattagaggc ctcagcaggc aacttgactg aatctcgtag 23280 tcaaattatt actttttttt tcctttttta attaatagaa ggtaatattt ttaaaagcga 23340 taaagccagg gaccttcaga cgtttgagaa gtatttaatt ttctatataa acatttcttg 23400 tttttaaatt actttaaata cttggattaa gttttgctct ggttacaggg cggccagcaa 23460 tagagcattg ctagaaagat tttaactcgc caggaatgtt tttggaaact ttgattcatg 23520 gcgtaacgtt ttgtgtaccg ttttttagca agtctgctag aattcacact ttatcaaagg 23580 atgtttttca acaaaggaaa ttcccaggaa ataccttgtg ggctgctgcc ctcaatcgct 23640 tcactgcata tttatttgct tccaaagaac tttcgtcaaa acaagcatac ttagcccaag 23700 actttgtcaa tgtctgcaag gatgccagtg tctttcagaa tgtatactat tatgagttaa 23760 aaaagaatat ccttacagat ttaggatttt ctgacttaaa aaactctgat aaatcattgg 23820 ctctttcaaa atcttcttct acttttgacc ttcagaaaat aaaaaagatc catgattgtt 23880 tactctcaga gtatcggaag tatgtacgat atcaagagcg aatagaagaa acaagacctg 23940 acttacaaaa gcaattaaca gatttaaaaa atccaattga gtggtatcca ggagcgagaa 24000 aactcagaag gcatatcatt atgcatgtcg gcccaacgaa tagcgggaaa acacataggg 24060 ctttagaaag acttaagact tgcaagaaag gtatatttgc tggcccttta agacttttgg 24120 ctcacgaaat ctataatcgc ttgcaagcaa acggaatagc ttgtaatctt tacacagggg 24180 aagagattag aaatgattat cctttccctc aggttgtttc atgtactgta gaaatgtgca 24240 acttatctac tacttttgat gttgcagtca ttgatgaaat ccaaatgatg gctgatcctt 24300 cacggggata tgcttggact caatgcttgc ttggcttgca ggctaaggaa attcatttat 24360 gcggagaaga aagtgttgtt aaattagtgc gttcaattgc taaaatgacc caagatgatt 24420 ttactgttta cagatacgaa cggttaaatc ctctccacgt tgcagaaaag agcttaaatg 24480 gaaagttaag tgaactcaaa gacggggatt gtgttgtggc tttttcaagg aaaaacattt 24540 ttactttgaa gtctaaaatt gatcaagcat taggaaaaaa atctgccgtt atttatggtt 24600 cactgcctcc tgaagtccgt aatcaacaag caagcttatt taattcaaag agttctgatg 24660 aaaatatttt gctggcctcc gatgccattg gtatgggtct caacttaggc gtaaagcgta 24720 ttgttttcag cgatttaaaa aagtttagtg gagtttccac tatagacatc cctgtaccac 24780 aaattaagca gatagcagga agagctggcc gacataatcc caatggatct aagcaaagtg 24840 ctggaatagt aactacccta tatcaaaaag attttgcgaa attaaatcgc gccatgaatc 24900 ttcctacaaa gaacttattc aatgcttgta ttggagctaa ggacgattta ttctttagat 24960 atttatcact attctctgat gacattcctc aaaagctaat tttcgatcgt tactttaagt 25020 tagcgaaaac gactactcca tttgttgtgt cggaaggagc actaagcaca ttcattattg 25080 aatatttaga ccacataaaa ggtttaacca ttaaagataa aatcaaattg ttagggtgcc 25140 cagtgttaaa gcattctaaa tacgcaccac tatttattcg ggaaatcgga tgtgttatcg 25200 ctcaaggaaa acgtctgcaa atatatgatt tgaagtctgt acctttggaa atattagaac 25260 gcggaattcc aaccactgaa accgagttac aacaactaga gcagcttcac aaattaatag 25320 tagcatacat gtgggctagt atacgatatc cagctatcct gcaaaatgga gcagccgaaa 25380 aaaccaaggc aatagcagag gcttttctaa tcaaaggaat atcgaaatta caaaagtaac 25440 taaaatgaaa taaaaggtta caaattagtc tctattcctt caaactttaa gtatcattaa 25500 tatatatcta ggagatactt taattatgag aatttttttt ttttttaaga aagacgacca 25560 gcatctaatc cattctttgt acagaattac catccaaatc gtagttggga agggtgaaaa 25620 acaggaggtt gccaatctgc caacaaatct ccattgatcc ttcttctttt tttgttcttc 25680 aatctttcgt attgttgctc aattccatct gaaatacaga taataaattg acctttgtaa 25740 tatttaagca tatttagtgc ttgaagtgta tgtagcacat cattagtagt cattgaagtt 25800 ttgttggcta attcgtcaat agtggtttca gttcgcattc caagcacaag gttgatgatt 25860 tgttcagccc aatacgctcg ataactaatc aaccccaaat cagaaagtgg tttttcaggt 25920 gagccgtgtt tgtgctcacg cttggtcaat tcataagaaa attgtatgag taacttgcca 25980 taaccatgtc tttggtattg aggtaaagtt aagatacaag caaggttgta attttcggag 26040 gactcttttt cttttgagaa atatcctacc aagtgacatc catattcatc gcggcgacac 26100 atacagtaaa acaaaaaggg atcaacatca tagtaaagca ttttgtgatc cagaaaaagt 26160 ttggacaaaa gacaaatatt cctacaccat gtacgttgct ttcttccatc aatttcaaaa 26220 aaggatatat agtcatcacg gtatatttca tttccgggtg gatgctgcaa tgtacatttt 26280 tcgcggtgtc tttgaaattg tcgctcagat ccgtaatagc agaaacaaaa actgcaaata 26340 taaactatat ctacttccga aaattcttta gggtacggtg agaagtacca aggttcaatt 26400 tcatgatctc ctatgcaaat tttgtttata ttacgaattc gagctatttc gtgaggattt 26460 tgaaccattg agccactgaa ccgtaacctt tctacttctt gttcttttga aagactttcg 26520 ggcttgtggt cttcctccaa taacggtaaa ctttcattcc cggcatttga tccatgatca 26580 ctttctccag aaggggtgga tggttcaggt ttctccgtag aaggcgtcga aggctcagtt 26640 tttgaaggtg ctgtaatcga tcgtcgtctg tcaacagctt ttggacgttt tgaggatttt 26700 ccttttccat gagccttttt tggcttctcc ggcggtggat actcaattcc tttcgataaa 26760 tcaatattat ctattgtaat ccattcatct aaacgtttat tgtagtcatt atagtgtaca 26820 tagtagacga cgcctctagt tcttttttga atcattaaaa tctccgcctt tcgatattct 26880 ccatccttaa atgcaaagac tttggattta taaactatgt ctttagcctc ataagacttt 26940 gtttcaatct tggactcatc atcaacatca ttcgacatct tgagtctcaa taagtggata 27000 cttattccat gtacaaattg tgtagccacc ctgaaaattt ttttttcatg gtggtgagtt 27060 ttgctagttt cgaaaacatt tctttaccga ttcgttaaat gtcggtatgt tttttgtgaa 27120 ctttactgct ttaaattaaa ttgtttagca aatttcgacg aatttacaat ctttgctacc 27180 ttgaaattca ttaagcgaga tgatttttaa agttagagtt tcgctcgtta ttatagcatc 27240 gacgtaatta ttctcaacct gcgcttacag caaacgatgc taaccttttc gtttccaata 27300 gaaagtaaat taattaataa aatttttgaa aggatgaaaa gagtaataaa tactttcatt 27360 ttacacatat caagatagct gtgataaatt aaacgatcaa cttcaaaaat cctgaaatgc 27420 tcaattaaaa ttagtgttct ttgataatat aaaaatctag aaaatatttt tctcgggttt 27480 gaacacgagt atattcgaaa tttgtccaga aagtaccgaa aatgctataa acagtaatac 27540 aattcttcag ttttccgttt ccaattaaaa gaataatgcc aataaggaat aatagaagta 27600 cttttcataa ttaagggaat ttacttcact aacgcgctca gctaattcac aaaaaccaat 27660 aaaagtatgt taggcacttt atttacaagg tatataccat catcccagct gctaaattaa 27720 taaacatgaa acgagcggtt gagatatatc ggaatgaaac ctgctacatt aaaaagtaac 27780 tttcccgatt gaaacagtca tcagccacag gtatgggtga acagaaaatg tatttattct 27840 gagtttatat ataataccta tatatttgtt gactggtgtt tcaaaagttc actatatatc 27900 aagaaacact atcatgaatt cattacagta acagtaaaat ggttcacaat caacattcaa 27960 gtgctttaaa cgggaatcaa aaagatacaa ttaagacggg tatgggggag ttacaaagac 28020 tgccatttaa aacacaacgg cagtgtaaca aatatacatg agcacatttc gtacctaatt 28080 tgcgaatata caatctttat acattccaag cattatgacc agtagcacta gcgttgtaaa 28140 taaagttgtt gttggcgcca gaatttcctt ggctatctgc gtatgaggga atttgttccg 28200 aaccataact tcgatttgta ttgacagcag agcttggttg cgacatacgg gtattcatcg 28260 tagaactttg acgctcgacg gctggacgga agtcatttgg atcatcatca tcatcatcac 28320 tgtcggaaac agctgatgga ccatttgcgt tgcttaaagg ttgtatatag ttcacattag 28380 caatatgggt attcaacgct tcccaccatc tcattagttc ggtgttgtta gaagcgcgaa 28440 acgcgtaatc gtttcgcgcg ccaaaaattt tcttagtagc atccttgcca gttattttaa 28500 acttgggttt cttctcagaa gggcgaccga tcagacaatc aggtatgtaa agggcgaatt 28560 cgggttcagg atcttgaagt gaatcagaag atttaaattc gtaaagatag ccagaatgtg 28620 taaaggcata aaaacctctt tgttttttct ttaaaaaact tgttttacga attaaataac 28680 cagccatgat aggtacagtg ggttggtcat tcttaccagg atattttata gcatcaacgc 28740 tgcggggggg aacagagcca tgaataaatt ccggctcacg ctttgcgtat ccggtccact 28800 cgccagcaag ggtttgtgct tctgatacgc gaacaacttc ttggaggtga ttaatagctt 28860 tgacatgggt ttgattcatc atgccctcaa actgcttaac cgtgtcttta atttttgcga 28920 taaggttttg ctcgaaacga aaagaaaatt cttgaagctg tgccactgct acggagtgat 28980 tgttctcttc ttgaacttgt cgagccaaac agtttagcac ttgtctatct acaataaaag 29040 ggtcgttctt aatgtttaca gtaggtggac tggatgctct ccatggtaaa agagcccgat 29100 ctagtaagga aagatacttt tgagtttccg cacgctgctt ttcaactact ttcacacctt 29160 ttgtaccttc cgctgcgatt ttcttacagt gttcacgaag gtcttcacga agaagttcta 29220 atatattgat gatagtacct ggcaactgga tagatatttg ctcgctatcc gaagcgatgg 29280 cagccgtttg gtctcgaagc gctgcaaaaa tatcttgaat tccgtgttct tcaaatacat 29340 tagcatcttt gtaaggatgg acaataactt tgctcaattt catatactcc tttgcattgt 29400 tttttgacgt tgactctaat tgcttaaaga atgcaatcag attttccacc aaatgtctcc 29460 atccttcaaa ccgataagtc aaggagttgc aaagtcccat atatgcgtct gtgtttggga 29520 ctgcatctcc gtttgaagcc tggtttggaa tctccgtcct ggttggaaat tccgatttcc 29580 ctgaaagttc catcttgttg gttcttggtg aagctttttt gacttggaac ttgttaaaga 29640 aaacgatctg ctcgtatgac gccaatcacc ctcctgaagg ggtttgctgt accgatataa 29700 atgttctggg ttggtattct gtttaacgta actcataata ggaaattggt ggtacttgaa 29760 gtaaagggtt ttgttggaaa tagaacattc agtgcttaag aaaaaatgtc aaagaaacag 29820 gtgaagcaaa atttgaactt gcaatgtatg ttcgacttgt atatttataa aattatcgac 29880 catcatcaaa caaaggcttg atatgctcgt tagttatggc aaacaatagg tgcttgcttg 29940 ggaacatagg tattttgtac ctttaatgag caattgatac attattggga aattatagtt 30000 gatagggagt ttgaaccaag gaaaaggttt ttcttctttt attcaaacgt ttcaatttct 30060 ttggttctgc tataaggaag taactcaaga aactgcctcc gttggactgg ataaatatgt 30120 ctattttctt tgaataggga aaagcaggaa gaatgatgga actagtagaa atcaagtttt 30180 gaggtcagaa aatataaata ttatactttg tactcctttt caaaaatact taattagtcg 30240 aattttcgcc atttttctat gtcgctaagc actcatattg caaatttttt actaaaaaaa 30300 taacgctatg aaagaaatta aacatagata ggttttagct cttttttttt tcctactcaa 30360 cttatccaac ctaatacact aaagtacctt ttgtttacat tttctaatac tgtacttcgt 30420 tgttttgcgt tatataaatt gtacgagtct tcgacacaag tgatgaagga cgattgcgct 30480 gcggcactat aagctgctga gatgcaataa aggtgtcttg gtattccaga gcatccttcc 30540 agcacccaaa catttgcata gttcgtattt tacccttgaa ggagggaata gcattcgctg 30600 tgaaaaaaaa gaagttactt ttttgatttc gtttttgaat ctcgtgtgtt tacttcgtct 30660 gtattgggaa aaccagtgtt gtatgaaact cggattgttt gtttttccaa attattcctt 30720 tctacgcttt gttaatcatt gaggtgtttt tcttgcattt ctttcatttc ccttttttga 30780 tcggagtaat taattaaatt actttaatat tccaaggcgc cccattgttg ctgtgctgtt 30840 tgacggacgg tcggctgtgc ttgtttctga gcggatctgt tcatgaaatt gctttttaaa 30900 ttccttagtt gaaaactgtt atttccataa agctattcca tgcggccaaa ggctattttc 30960 tgatttgtat tgacgaatta tccgtctagt acccaacctt actagaattg gaacatttta 31020 tttattttcc tttttttttt taaaaacgaa aaaaaactgg acttttgttt cgcaaatacg 31080 gattggcaac ggtgggaaga ttgaaagaag acctattgtg attattactc acgtattggg 31140 gtgtctcatt ttcctttgta aataatattt gaaaccattt tattctactt ttctttcttt 31200 cttctcaaat taaagtataa taaagtactt gtttattcaa atcctttgat ttgccccttt 31260 ttcttttttt gtttttactt tgcttttcat taaatatttt caacttgttc atttctagga 31320 tacattttga gagcattgca acttcaattt cctctgcaac ttaacttcct atttcttctt 31380 atttttttaa ttctctcaca aacttggcat acgattcctt tctttctttt ttatttgatt 31440 aattctgtca aactattttt tcaactgatt ggttctcttt cttttctttt tccttttaaa 31500 taaaaaataa tgtctagttc ttcagtttct aatactctat ccattgagac taaaagtgac 31560 cctaaagatc ctgctttcgt tgcttctcag gaatctactg aatgtaatga acatgacaca 31620 acccagctat ctggctcttc atctgaacca cttgagaata attcctcttt aactcgctca 31680 acagatgatc cgtcggtaga aattcgttcg aagttggtga gccctgataa tgaagctaac 31740 ttattgagtg atcaaaatat cacaatatca aatgaaaaca acaatgaaaa cgataccaca 31800 gaagaagcgg agacttctag cggtaacgaa gctgccgatg atgaggattc ctcctctgat 31860 gctcagtcat ctgtcccttc tttttcggaa attcatgatg ggatgtctga agaagagttg 31920 gataaagaga ggaaaactct aacacatctt cgaagaatat ctctgcaagg agctgatgat 31980 cctgagattc caactgactg gtcagttgcg atgtccccac ctgaaaccga acaagatgca 32040 tctaccctat tctgggtacc agcaaattta catcctgaat tgaacccgac tggttggaaa 32100 tcgtttttgg accttcaagt taaaaacctt aagtccccta ctgctacaga cacatcttca 32160 agtcctcttg agcacattcg ttccctaaga agaagaaagt cattgttgtc acgacaggtt 32220 aaagctgacg atgctgtaat taattaccaa gatggcagtc cgatcgtgga gaaagcgtat 32280 ctcaaaaggc atagatcttt acgcttgaat gagttagagc atttggaatc tcttgcacgt 32340 gatccccata ggatggtttc tttagttgat ggcatgagca acggctctcc cgaagattcg 32400 cctttactag tatctcctaa tcattttctt caacgttcct caaggacgac aattcgaagg 32460 acaggtgctt cgattcggac tatccaccgg ggtaaaacat caactctatc tggcaaccgt 32520 agtcactcta ttttgcaaaa gccgaccgat acttcgcctc tacataaaat agagcccata 32580 tctgctgatg aacttgttga gtcggatgac tctagaactt cggcgctgtc aaactctcaa 32640 aatccatcgg acgatgttga aaaccaatct gaccaagctc tagaggtttt atccttgacg 32700 aatccaccaa agattgataa cgcctctgca gatacaacct tacataaaga gacgaataag 32760 atcgataagc tgtatgtttc ggagaataaa gctgaaagtg ctgttgcatc tgaatcttcg 32820 ttatccgaag gtactctcgc attgaaagca ccggcaccgg aaaacaaacc tgaaaagtct 32880 agtacatcga aaccgccagt accagaaaat aaggctgaag attctgttgt attaaagtcg 32940 tcggtaccag aagataaatc tgaaaattct attgcgtcga aaccgtcggc aacggaaggt 33000 ataccggaaa atgctattgc gttgcaatca tcggtaccag aaaataaggc tgaagattct 33060 gttgtattaa agtcgtcggt accagaagat aaatctgaag attctgttcc gtcgaagtcg 33120 tcggtactgg aggataaaca tgaaaattct gttgagattg ataaaaaagc agatgactca 33180 ttaccttcta ataataaaac tgagggttat acaccttcag tagtccgtga ggaaaagaat 33240 tattctgaac cgaacgcttc tccttccgta atacctccta gagtccctac tcctgtgcct 33300 ggtaggactt taagtccaaa gcctactagg atacccacgc ctattccttc ttctttgaac 33360 gtttctttag agtcctcaaa aaagccagag atttttcatg agcgtcatat tccgactcct 33420 gaaaccggtc ctaataagcc atcgaaaaac aatattttaa aaagcactca agttcccgtt 33480 actccaaaac aaaaatcatc cactgctaac aaaggttcaa cttcttcacc aagtccaccc 33540 tcttctgaat caaagaaaac caagaggtcc tggggccgtc tttttgtgtc tggtgattct 33600 gataaagaac acaaagaaca caaaaaagat aaacagaaaa agaagaatga ccaaatttct 33660 tcttcttcaa agtctgcttc ttcttttaaa aaggaccgag acaaggaaag catttttgga 33720 tctttatttg gctcgaagaa aaagcagacg gaaatacccc ctgtatcttc ttctccaccg 33780 cataatgatg ccccaccaaa agcaaagcca atttccgcac ctagtgaatt gcccaatacc 33840 acttctgtcg cagaagctaa gtgtcagaca gtgacagatg acgaaggtac cgatcaacaa 33900 agtgatgaaa agagtacgga accaaaaacg tttattcctg ataaggatta ttactggagt 33960 cgttttccaa tttgtactga acgtgccatt tatcgtctct ctcatataaa gttgtcaaac 34020 gcgcatcgcc cattgtttca acaagttctc ttaagtaact ttatgtattc atacttagat 34080 ttaatttctc gaattagctc aaatcgcccg atgaataatg tacaacagtc tactgctaaa 34140 ccaatacgca aagacattaa tggacaacaa aggcgttcag agttttcagc agaaaatgta 34200 aaaaacgagc tggagaatct cagttatcaa tttggagatc agcgtaagcg aaatcttaat 34260 aggaaaggat cgactattca taccgtttct caaaatattc aaaaagtttc aaagaatgct 34320 aaataatcat tttaccctac tgctattcgt tggtctaaca tttttcctca ttggttaatt 34380 attagcattt ggcgactttt gttatatgtt acagggtctt cattgtcttt aaaaatttgt 34440 atcttgttca ccaacacttt ctggaagcag gtggttattt attttcatga gttaaatata 34500 aaattcttac tcaatgcata agtttctaat gaatttcatt cgctatgcta ctttacattg 34560 taaggggagt acgaagttac ccattctata ataaattacc aattcttttt cgctttatat 34620 ttgtacatag cctctatttt gaagtaatca tagaacgcta ctgaagtgct atacaataac 34680 tttttttttc taaacaatgc ttaggataaa tgaaaactgc cctgtccttc taaaatagcc 34740 ttagaaagtc gacttcctaa aacctcactt gaagaatact caggtagttt caaataattc 34800 acacaagtca tcacgcttgg aagataatca tcaggtacat aaggaggttc atttaagcgc 34860 ctaacaacag ttaacggggg atttaggcca gcaaatcctc caataggaag ttttcggctt 34920 ccagtaataa attgcaaaaa gtctctttgt tcttgaaaat tcatttgact catcaaagtc 34980 agtaatctct ggattgtagg actttccatg gtgtaaccgt gatctgctac tatagatttc 35040 atcaaggtcg cgtaactcca atcctcatcg acagtaccga atagtgtgac caattcatgt 35100 tctgtcaaaa cttgcaaaga agtataagga aaaacgctgg aaaacccatt ttgaaatgct 35160 tctaattgtt gttgaacacc ctttccaaca gtatagtcaa tgacataatt taaataatca 35220 ctcacattga atgttgtcac aggtgtacta gctccatcag gtatgagttc aatagacgga 35280 aatcccggta gagtaaaatc gagatgaagg tcttcaagct taatgtccgt ctcggcgttt 35340 gtagggtttt tacccggtat taatttctct aaatatcgta acgagttagc taagcccttg 35400 tcaactttcg ctacagagga aatggttaaa ggtatatttc gtgcaaagaa aagtggatta 35460 aactgaatgc ttattatcct tgaatcataa atcgagcgtg caacgaactg tccaagagca 35520 aagaacaacg aaatttttct ttcattttct ggactggacc ctaataatgg aataggagaa 35580 ggaaaaagtc cagacgcttg gtacacaaat ttagagttgg gttgatcatt ccgccaaata 35640 tcgagagaat ttaaggtaaa ttctttagat actgaagtat agaactccaa agtgggccca 35700 agacctgaac caacttcatc ttcgtattct atttcaagaa tattttcaga agccgcataa 35760 gttgcaagca aatgcaaagc gtaattaaat atttttttcc gagaaatacg aattttctgg 35820 cgatgtaagc tgacaaattg aagtatggag gaactttcgt tttttgatag ctcaggattt 35880 cgggacaaaa gaaaagaaac ggatc 35905 //