ID SPAC521 standard; DNA; FUN; 10964 BP. XX AC AL163481; XX SV AL163481.1 XX DT 07-APR-2000 (Rel. 63, Created) DT 07-APR-2000 (Rel. 63, Last updated, Version 1) XX DE S.pombe chromosome I cosmid c521. XX KW 40s ribosomal protein s8; calcium permease family membrane transporter; KW confirmed intron (x2); dna-directed rna polymerase ii 138 kd polypeptide; KW rpb2; rps8-2; short chain dehydrogenase; signal peptide; yeast YHR134W. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-10964 RA Brown S., Harris D., Wood V., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (04-APR-2000) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; Q02061; Q02061. DR GOA; Q09814; Q09814. DR GOA; Q9P7B2; Q9P7B2. DR GOA; Q9P7B3; Q9P7B3. DR GOA; Q9P7B4; Q9P7B4. DR GOA; Q9P7B5; Q9P7B5. DR SPTREMBL; Q9P7B3; Q9P7B3. DR SPTREMBL; Q9P7B4; Q9P7B4. DR SPTREMBL; Q9P7B5; Q9P7B5. DR SWISS-PROT; Q02061; RPB2_SCHPO. DR SWISS-PROT; Q09814; YABF_SCHPO. DR SWISS-PROT; Q9P7B2; RS8B_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c521 is overlapped at the 5' end by cosmid c2G11, EMBL CC entry SPAC2G11, accession number Z54354, and at the 3' end by CC cosmid c23G3, EMBL entry SPAC23G3, accession number AL138854. XX FH Key Location/Qualifiers FH FT source 1..10964 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c521" FT /map="IL" FT misc_feature 1..103 FT /note="515 (+1) 36060 36162 SPAC2G11 S. pombe chromosome 1" FT CDS join(complement(388..557),complement(193..308), FT complement(1..120)) FT /db_xref="GOA:Q09814" FT /db_xref="SWISS-PROT:Q09814" FT /label=SPAC521.01c FT /note="SPAC521.01c, " FT /partial FT /gene="SPAC521.01c" FT /gene="SPAC2G11.07c" FT /product="conserved hypothetical protein" FT /protein_id="CAB86465.1" FT /translation="MNKNEELDEDELLKKCIICPPVPKALKKYWNNRYNLFSRFDEGIW FT LDYQSWYSVTPEKVAVAIAKSVVDFIQPELIIDAFSGCGGNTIQFAKYCPVISIEIDPI FT KIAMAKHNLEIYGIPSSRVTFIQGDVLDTFK" FT misc_feature complement(121..138) FT /note="ttaacgcttttgtttcag, splice branch and acceptor" FT intron complement(121..192) FT /note="confirmed intron" FT misc_feature complement(187..192) FT /note="gttcgt, splice donor sequence" FT misc_feature complement(309..326) FT /note="ctgacaaattataattag, splice branch and acceptor" FT intron complement(309..387) FT /note="confirmed intron" FT misc_feature complement(382..387) FT /note="gtatgt, splice donor sequence" FT CDS 1300..2151 FT /db_xref="GOA:Q9P7B5" FT /db_xref="SPTREMBL:Q9P7B5" FT /label=SPAC521.02 FT /note="SPAC521.02, len:284, signal sequence predicted 1-20 FT aa, SIMILARITY:Saccharomyces cerevisiae, YHT4_YEAST, FT hypothetical 30.6 kd protein in act5-yck1 intergenic FT region., (269 aa), fasta scores: opt: 194, E():2.9e-06, FT (28.0% identity in 189 aa)" FT /gene="SPAC521.02" FT /product="hypothetical protein, similar to yeast YHR134W" FT /protein_id="CAB86466.1" FT /translation="MIAILYLYYILTTSILLSVSFMLRINDDDHPNEKIGFISAIKGDF FT HDLSSDYLKRIAAMAFPIMKEHGFGVTSLDEVAYNAKFWGRNWNKGECIELVLRDASNR FT WLPFEFVMDVFLHELCHIWQGPHDRRFFSHLSTLRAALIALYAKGYKGPGKYMTWDSFV FT LANVVGNYNTVVFNGITLERSTMHGVETCGGSLQRKKKIRRKPTPSSTKKRKLTRTGQK FT LGTDMNIRLELLKSPAKPQAQSMRGREARIAAALLRVDNSNEYKPKDHNSSTTLENYFV FT VE" FT misc_feature 1639..1668 FT /note="PS00142 Neutral zinc metallopeptidases, zinc-binding FT region signature, " FT CDS 3212..3991 FT /db_xref="GOA:Q9P7B4" FT /db_xref="SPTREMBL:Q9P7B4" FT /label=SPAC521.03 FT /note="SPAC521.03, len:260, SIMILARITY:Saccharomyces FT cerevisiae, YM71_YEAST, hypothetical oxidoreductase in FT mrpl44-mtf1 intergenic region(ec 1.-.-.-)., (267 aa), fasta FT scores: opt: 858, E():0, (49.8% identity in 257 aa)" FT /gene="SPAC521.03" FT /product="putative short chain dehydrogenase" FT /protein_id="CAB86467.1" FT /translation="MSRLDGKTILITGASSGIGKSTAFEIAKVAKVKLILAARRFSTVE FT EIAKELESKYEVSVLPLKLDVSDLKSIPGVIESLPKEFADIDVLINNAGLALGTDKVID FT LNIDDAVTMITTNVLGMMAMTRAVLPIFYSKNKGDILNVGSIAGRESYVGGSVYCSTKS FT ALAQFTSALRKETIDTRIRIMEVDPGLVETEFSVVRFHGDKQKADNVYKNSEPLTPEDI FT AEVILFALTRRENVVIADTLVFPSHQGGANHVYRKQA" FT misc_feature 3230..3793 FT /note="Match to PF00106 adh_short, short chain FT dehydrogenase Score 180.12" FT CDS complement(4398..7043) FT /db_xref="GOA:Q9P7B3" FT /db_xref="SPTREMBL:Q9P7B3" FT /label=SPAC521.04c FT /note="SPAC521.04c, len:882, SIMILARITY:Saccharomyces FT cerevisiae, YN61_YEAST, hypothetical 102.5 kd protein in FT kre1-hxt14 intergenic region., (908 aa), fasta scores: opt: FT 807, E():0, (36.6% identity in 936 aa)" FT /gene="SPAC521.04c" FT /product="calcium permease family membrane transporter" FT /protein_id="CAB86468.1" FT /translation="MSQPADINQSESSAETITQGRRADRPEETPSSSVYEQNLRFGDFL FT MPTVGDADATDSLSQSTNDRDIYSPREIDQYTRKVSSRTDPSTSTISNARQHPRNSVSR FT LSRSSSNVRQQRDIPKQNFKVRPLSPLRGQSPASLRSEESFTLKERQNAINKTRAFGMR FT LWKPALYKKFRSINRDADIDIHDEPLKRPNTSISNVIWLICFGAPLFLVIFICYIFFTV FT LSFFNVPDAIVYSKLCRGLMFYLLYPFGQHVRHKVKRLSVRSPAHPIYQTQHSHYDETP FT TSHHPDPARLNFLSFSFCVNPMNQSLDCNTTPHRRNASSIIYTLMYYLIIAPTLLITSA FT ICMFTIFFVPCARTLWAICRHLRTCPLSLSFRPNLALPLSMDSSDVVLLCVKKAASWKY FT YKYTIDGIYIIYFDMLALIIPTIFFGFFGSQGHWFTSSVFLFTASLVSIIPLAYFIGMA FT VASISAQSSMGMGAFINAFFGSVIEVFLYSVALRKGNAGLVEGSVIGSILAGLLLMPGL FT SMCAGAIRKKFQFFNIKSAGATSTMLLFAVLGAFAPTMLFRIYGPFRLDCEPCGANCQK FT CTKHYVLENDSLYKNRVLPFTYCCSIMLVLAYAIGLWFTLRTHASHIWQNFTADDISFL FT KAEEEVGEPVNQDTAGNMSDSSEGGEAVVNGNSQHHHNRDDASSGLSSNGSENESLEHE FT PTNELPQRPLVNQSQNSHGDDAPNWSRSKSAIILLSATFLYSLIAEILVEHVDTVLDKF FT AISEKFLGLTLFALVPNTTEFMNAISFALNENIALSMEIGSAYALQVCLLQIPCLMGYS FT LFQYYRSGDSISFKHLFTMVFPTWDMICVMICVFLLTYVHSEGKSNYFKGSILVLAYLV FT SMLGFTFFNY" FT misc_feature complement(4833..4880) FT /note="PS00038 Myc-type, 'helix-loop-helix' dimerization FT domain signature" FT CDS 7587..8189 FT /db_xref="GOA:Q9P7B2" FT /db_xref="SWISS-PROT:Q9P7B2" FT /label=rps8-2 FT /note="SPAC521.05, len:201" FT /gene="rps8-2" FT /gene="SPAC521.05" FT /product="40s ribosomal protein s8" FT /protein_id="CAB86469.1" FT /translation="MGITRDSRHKRSATGAKRAQYRKKRKFELGRQPSNTRIGPKRIHE FT VRVRGGNKKFRALRLDSGNFSWGSEGVSKKTRIIQVAYHPSNNELVRTNTLTKSAIVQI FT DAAPFRVWYETHYGILMGSKGKKATATPTPKSKHVQRKHSARLGDSKVDSALETQFAAG FT RLYAVVSSRPGQSGRCDGYILEGEELHFYLRRMAPKK" FT misc_feature 7593..7967 FT /note="Match to PF01201 Ribosomal_S8e, Ribosomal protein FT S8e Score 274.45" FT CDS join(8743..8758,8797..10964) FT /db_xref="GOA:Q02061" FT /db_xref="SWISS-PROT:Q02061" FT /label=rpb2 FT /note="SPAC521.06, len:728" FT /partial FT /gene="rpb2" FT /gene="SPAC521.06" FT /gene="SPAC23G3.01" FT /product="dna-directed rna polymerase ii 138 kd FT polypeptide" FT /protein_id="CAB86470.1" FT /translation="MSYEDYQYNETLTQEDCWTVISSFFEETSLARQQLFSFDEFVQNT FT MQEIVDDDSTLTLDQYAQHTGAQGDVTRRYEINFGQIYLSRPTMTEADGSTTTMFPQEA FT RLRNLTYSSPLYVDMRKKVMVAADSNVPIGEEEWLVEEEDEEPSKVFIGKIPIMLRSTF FT CILNGVSDSELYDLNECPYDQGGYFIINGSEKVIIAQERSAANIVQVFKKAAPSPIAYV FT AEIRSALERGSRLISSMQIKLMARNTENSGQTIRATLPYIRSDIPIVIVFRALGVVPDR FT DILEHICYDPNDFQMLEMMKPCIEEAFVIQDKDIALDYIGKRGSTTGVTREKRLRYAHD FT ILQKELLPHITTMEGFETRKAFFLGYMIHRMLLCALERREPDDRDHFGKKRLDLAGPLL FT ASLFRMLFRKMTRDVYKYMQKCVETNREFNLTLAVKSNIITNGLRYSLATGNWGDQKRS FT MVNRVGVSQVLNRYTFASTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGMVCPAETPEGQ FT ACGLVKNLSLMSYVSVGSPSAPIIEFLEEWGLETLEDYNPSASPNATKVFVNGVWLGVH FT RDPAHLTETLRSLRRRLDISAEVSIVRDIREKELRLFTDAGRICRPLFIVDNNPNSERR FT GELCIRKEHIQQLIEDKDRYDIDPEQRFGWTALVSSGLIEYLDAEEEETVMIAMSPEDL FT EASRQMQAGYEVKEELDPAQRVKPAPNPHVHAWT" FT misc_feature 8759..8764 FT /note="gtaagt, splice donor sequence" FT misc_feature 8782..8796 FT /note="ttaacaccataatag, splice branch and acceptor" FT misc_feature 9075..10955 FT /note="Match to PF00562 RNA_pol_B, RNA polymerase beta FT subunit Score 501.71" FT misc_feature 10857..10964 FT /note="540 (+1) 1 108 SPAC23G3 S. pombe chromosome 1" XX SQ Sequence 10964 BP; 3604 A; 1986 C; 2109 G; 3265 T; 0 other; atttaaaagt gtcaagaacg tctccttgaa tgaaagtgac tcgagatgaa ggaatgccat 60 aaatttccaa attatgcttt gccatagcga ttttgatagg atcgatctca attgagatta 120 ctgaaacaaa agcgttaata aacagtgata tgatacagat gtaaggttga taacaaacta 180 ttacaaacga acctgggcaa tacttggcaa actgaatagt gtttccacca catccagaga 240 aggcatcaat tattagctcg ggctgtataa aatctacaac cgacttcgcg atagcaacag 300 ctacttttct aattataatt tgtcagaccc attcaaatgc aaacaacaaa atcactgata 360 ttaatacatg aatgctatta tacatactcg ggggtaacac tataccatga ctgataatcc 420 aaccagattc cttcatcaaa tcgtgaaaat aaattgtatc gattgttcca atatttttta 480 agagctttgg gaaccggagg acatatgata cattttttta atagctcatc ttcgtcgagt 540 tcttcgttct tgttcattca aatttttttt tcgattaaac tacttttttg tgaaatttag 600 tcaacaatcg ttcacgatca acccgaaatt tatcgatatt cgttgctaat ccaaaagtcc 660 ttaattaacc gttactgaat tgacgaaatt tgaagtgtgt tcaaaaaatt cggtgttttg 720 ttactcaaac tccaaaaatt gtgaatgaaa agttcaatgc tctttcagaa taataaagca 780 atgaaatcag acacatatac agctaaatat gaaaaacatg aaaaagaatt tatctttgac 840 ttattcacga atttcgtttg cttccttcat caacatatat atatatacca tgggaatcga 900 tatgttacaa tttaaataaa actcattgtc tgcttataag aaaatttatt caatttaagc 960 attttataat ccttttacaa tttgttaaaa aggatgtcag taattgtgtt tagaaaagta 1020 tttagtaata tatatatttt ttgtcaataa atattttatt acatattttt tatcggtgtt 1080 gccatcgatc tgtatcgata ggaagcaatt tcactaaact tattgaaatt aaggtaataa 1140 tataatttta acagaaaatt aattgattgt gaaaatatgt taatttttgt actgtaatgt 1200 ttttcatttc tatttatttg catttgaaaa ttatttttcg ttaagcgaat tcaagaagcc 1260 ctatgacggt accataaaat attaaaacgc agtaactcca tgatcgctat attgtattta 1320 tattatattc tgactacgag tatcctttta agtgttagct ttatgctacg aataaacgac 1380 gatgaccatc caaatgagaa aataggattt atatctgcta taaaaggaga tttccatgat 1440 ctatcttctg attatttaaa aagaattgcc gcaatggcat ttcctattat gaaggagcat 1500 ggattcggag tcacttcgtt ggatgaggtt gcttacaatg caaaattttg gggaagaaac 1560 tggaataagg gagaatgtat tgagcttgtc cttagagacg cttcaaatcg atggttacca 1620 tttgaatttg tcatggacgt gtttttacac gaactctgtc atatttggca ggggccgcac 1680 gatcgtcggt ttttcagtca tttatcaact cttcgagctg ccctgattgc tctttacgcc 1740 aaaggttata aaggccctgg aaagtacatg acttgggatt catttgtcct tgccaatgta 1800 gtaggaaatt ataacaccgt tgtatttaac ggaataactt tggaacgcag cacaatgcat 1860 ggtgtggaaa cttgtggtgg atctttgcaa agaaaaaaga aaatcagaag aaagcctacc 1920 ccttcctcaa caaagaagcg gaagcttaca cgaacaggac aaaagcttgg aactgatatg 1980 aacataagat tagagctttt gaaatcacct gcaaaacccc aagctcaaag catgcgcgga 2040 agggaagccc gaattgcagc ggcacttctc cgagtcgaca attctaatga atataagcct 2100 aaagatcaca atagctctac aaccttggaa aactatttcg tagtagaata aattagacaa 2160 cagaataaat acataaaaaa gaaaaaaatt tgtatacaaa atcaaatcac ctttaaattg 2220 tagcattttt tgggggacat ttcgtactag agtaacacga ttaacaaaga gaaataatga 2280 atacattaaa acaaacagct ttcatttaaa gactaatata tctcttaatg attgataaac 2340 caataaaaat gtattaaaac aaaatatcat aaaaaatggc agaaagtatt gttcaaaaaa 2400 aaacacatag aaatgggaat tcgctagctt tcctaagtaa taaatttcaa tagataggga 2460 aaaaaaaaat aaaaaaaata aataaaaaaa taaaatgaaa ataacttaaa taaccaaaac 2520 cctcgtttca gcaccaatta ttgaaaaaat ccattattaa gctgcaaaac agtgttgaaa 2580 cctgcatgtc aaaaaaattt cgcgaaaagg taagcataaa tttcaacctt acttccctat 2640 cactaccaat tgcgtattac attactatat gcgattacta ttcactaatt ttctggggag 2700 atcttctgtg atctaacgct gaaatttgca atcattcgca attatatttt attccaagat 2760 ctctaaaaag agtctttttc cgttgaaaag aacatttccg atgttctacc atctcattca 2820 tatacaaatc ctaactgctt aaggaaaatg atttccgcgg atattccacg gagcagccaa 2880 ttaatgaggt tttcggtaga taatctgcta ataacgataa aaaactatct aatattatca 2940 aattgataga atatatatat aggagcaagt taggagttat gaacctcgta aatattagga 3000 acctcaataa agtcttggcg cactaatagg taacctaaac caagtacagt ctgttgattt 3060 aaatcatcac ccccacgtta ttttctaagt ctggaacatc tagattttta ctgtggtttt 3120 attatataaa ttacgttcat ttgtaatttt atctttgtat ttattttttt gttcttactc 3180 ttcaaatact ttctgcctta tatctttaaa aatgagccgt ttggatggaa aaacgatttt 3240 aatcactggt gcctcttctg gaattggaaa aagcactgct tttgaaattg ccaaagttgc 3300 caaagtaaaa cttattttgg ctgctcgcag attttctacc gttgaagaaa ttgcaaagga 3360 gttagaatcg aaatatgaag tatcggttct tcctcttaaa ttggatgttt ctgatttgaa 3420 gtctattcct ggggtaattg agtcattgcc aaaggaattt gctgatatcg atgtcttgat 3480 taataatgct ggacttgctc taggtaccga taaagtcatt gatcttaata ttgatgacgc 3540 cgttaccatg attactacca atgttcttgg tatgatggct atgactcgtg cggttcttcc 3600 tatattctac agcaaaaaca agggtgatat tttgaacgtt ggcagtattg ccggcagaga 3660 atcatacgta ggcggctccg tttactgctc taccaagtct gcccttgctc aattcacttc 3720 cgctttgcgt aaggagacta ttgacactcg cattcgtatt atggaggttg atcctggctt 3780 ggtcgaaacc gaattcagcg ttgtgagatt ccacggagac aaacaaaagg ctgataatgt 3840 ttacaaaaat agtgagcctt tgacacccga agacattgct gaggtgattc tttttgccct 3900 cactcgcaga gaaaacgtcg ttattgccga tacacttgtt ttcccatccc atcaaggtgg 3960 tgccaatcat gtgtacagaa agcaagcgta ggcattaaaa ctatgttaca aagctgttcg 4020 ttattattac gatttagcaa ttaagttcaa tttaatgtat gcatgaagtt ttgaaatttt 4080 attaataaca cgtttcccaa ctatttccga cattcggtta tatcagaaga tattcgttat 4140 tcattagttt tcgtcaatgc ttgagggccc ataaaacgta aaaaaatata aacatgaaaa 4200 tgataaagca taacttgatt gaaaattgcg tatagagatc gaagcctctt cgtttcttat 4260 tacaaaaatg gttcactgaa tgaaacgcaa gtttcaaagt gatgatgtaa gctaaaaata 4320 ataatctata ataaaagtgt aaaaataact agagctcaat tacaacatat tgacaacaag 4380 gtgtgcagag aaaaaatcta gtagttgaag aatgtgaaac caagcatgga gacaaggtat 4440 gccaatacca aaatcgaacc tttgaaatag ttgcttttcc cttctgaatg aacataggtt 4500 aacaagaaaa cgcaaatcat cacgcaaatc atgtcccacg ttggaaaaac catggtaaac 4560 aaatgcttaa acgatattga atcaccagaa cgataatatt gaaacagact gtatcccatt 4620 aaacaaggta tctgcaaaag acaaacttgt aaagcataag cggacccaat ttccattgac 4680 aaagctatat tttcatttaa cgcaaatgat atagcattca taaactcagt tgtattcggt 4740 actaaagcaa atagagtaag tccaagaaac ttctcgctaa tggcaaattt atccaaaacc 4800 gtatctacat gttcgacaag aatctcggca atgagggaat ataagaatgt tgccgacaaa 4860 agaatgatag cactcttgct tcttgaccaa tttggagcat cgtcaccgtg ggagttctga 4920 ctttgattaa ctagaggtct ttggggtaac tcgtttgttg gttcatgctc tagcgactca 4980 ttttcacttc cattagacga caaccctgaa gaagcatcat cacggttgtg atgatgttga 5040 gagttgccgt tgacaacagc ctctcctcct tcagagctat ccgacatatt gcctgcagta 5100 tcttgattta caggctcacc aacttcttcc tcagccttga ggaaagagat atcatcggcg 5160 gtaaaatttt gccatatatg ggaggcatga gttcttaaag taaaccataa accaatcgca 5220 tatgccagta caagcataat cgaacaacag taagtaaatg gaaggactct atttttatat 5280 agtgaatcat tttctaaaac atagtgtttc gtacacttct gacagttcgc gccacaaggc 5340 tcacaatcta acctaaaagg accatagatt cgaaaaagca tagtgggggc aaaagcaccc 5400 aaaacagcaa aaagaagcat tgtgctagtt gcaccagcag actttatgtt aaaaaactga 5460 aatttctttc gaattgcacc agcacacatg gagagcccag gcatcaaaag taaaccagct 5520 agtatactgc caattacact tccttcaacc agtccagcgt tacccttacg cagagcaact 5580 gagtaaagaa atacctcaat tactgaacca aaaaaggcat ttataaaagc gcccattccc 5640 atactgcttt gagccgaaat tgaagccacg gccattccaa taaaatatgc aagagggata 5700 atactcacca acgaagcagt gaataaaaat acagaagaag taaaccaatg accttgggat 5760 ccaaaaaagc caaaaaaaat ggttgggatt atgagcgcta gcatatcaaa ataaattatg 5820 taaataccat cgatagtata cttataatac ttccagcttg ctgctttttt tacacatagt 5880 aagacaacat ctgaagaatc catcgataac ggcaaagcga gatttggacg aaaagacaaa 5940 gataatgggc aagttcgcaa atgtcgacaa atagcccata aggtccttgc acatggaacg 6000 aaaaaaatag taaacataca aattgcagag gtaatgagta gtgtcggagc aataatcaag 6060 taatacataa gtgtataaat gatactggaa gcgtttcttc gatgtggggt agtattgcaa 6120 tctaacgatt ggttcattgg attaacacag aaagaaaacg aaaggaagtt taagcgggcc 6180 ggatccgggt gatgtgaagt aggagtttca tcataatggg aatgttgagt ctgataaatt 6240 ggatgagcag gagagcgtac tgatagacgc ttgactttat gtcgaacatg ttgaccaaag 6300 ggatagagga gataaaacat aaggcctcga caaagcttag agtaaacgat cgcgtcaggc 6360 acattaaaaa atgaaaggac tgtaaaaaat atataacata taaagatcac tagaaaaaga 6420 ggagccccga aacaaatcag ccatatgaca ttagagatgg aggtgttggg gcgtttcaga 6480 ggttcatcgt gaatatcaat gtcagcatca cggtttatgg atcggaactt tttatataat 6540 gcgggtttcc atagccgcat cccgaatgca cgagtcttgt taatagcgtt ttgcctttct 6600 ttcaaagtaa aggattcttc agatctgaga gaggcgggag actgacctct taagggagac 6660 agaggacgta ccttaaagtt ctgcttagga atatctcttt gttgccgaac attactagaa 6720 ctacgactta aacgagatac cgaatttctg ggatgctgac gagcatttga aatagttgaa 6780 gttgatggat cagtccgaga ggaaactttc cgagtatact gatcaatttc tctaggagaa 6840 tatatgtcac gatcattggt agattgggat aatgaatccg ttgcatcagc gtcgcccaca 6900 gttggcatta agaaatcgcc gaatcgcaga ttctgttcat aaactgaaga agaaggagtt 6960 tcttctggtc tatcagcccg tcgaccctgg gtaatggttt ccgcagagct ctcagattga 7020 tttatatcag caggttgaga cattgtaggc ggtagtaatt gtcacaatga ttacttttcc 7080 gaatcaaacc ctcgccaaat attctatccc ttaaaacacc tgtacgtagc taagaggatt 7140 gagtaaatag gtatttataa aaaattgttg aaggaatagt gagaaaggaa ggcatgattg 7200 gaaaggttgc gatcattttc tattacgcat atcataatca gaataccaaa ttgaaaaaaa 7260 gaacgccaat tctacaatat cgaagtcctc ccattagttc gttaatgagc atacaatgtt 7320 tacttcgtta aagattgtcg ggatgaattg agcttaatca gagccgagca tcgttgtaca 7380 gtttactaaa tgtagagcta agcgataata cgctaactta cggtatcggt ttttgtaaga 7440 atacaccgaa tttcgttaag tacaaagtat tagtagtagt atgaaacaaa aataacagtc 7500 acagccaaac ccaaacaatt tcagttactg tgttatatac tagttcatcg taaccacagc 7560 aaatctcttt ctgcaaaagg atcaggatgg gtattacgag agattcccgc cacaagcgct 7620 ctgctaccgg tgctaagcgt gctcaatacc gtaagaagag aaaattcgag ttgggtcgtc 7680 aaccttccaa cactcgtatt ggacctaagc gtatccatga ggttcgtgtt cgtggtggaa 7740 acaagaagtt ccgtgctctt cgtcttgact ctggtaactt ctcttggggc tctgaaggtg 7800 tttccaagaa gactcgtatc attcaagtcg cctaccaccc ttctaacaac gagttggttc 7860 gtaccaacac tttgaccaag tcggccatcg tccaaattga tgccgctcct ttccgtgttt 7920 ggtatgaaac tcactacggt attttgatgg gaagcaaggg taagaaggcc actgctacac 7980 ctactcccaa atccaagcat gttcaacgta agcatagcgc tcgtcttggc gattctaagg 8040 ttgattccgc tttggaaact cagtttgctg ctggccgttt gtatgctgta gtttcctctc 8100 gccctggtca atctggtcgt tgcgacggct acatccttga aggtgaagag ttacatttct 8160 accttcgtcg tatggctcct aagaaataag gttgtttctt caataaatta gttcataaag 8220 gaaggaataa aaggattccg agattgttgt atttcacctg tattgttgat tattatcagt 8280 aaccaaggtc gttaattatg tagagaaggt aatttttatt attggcattt agaaaagtgt 8340 ctgctaaatg tttagtaatc tctccatttg tcccaatcag taattgaaat tcgtttatgt 8400 gctattagat atgatttctt tactaaatct cattgaacta cgtttagtga agcctttacc 8460 tttttaataa aaattcacgc taagtagcct tttacacata atgaaagagt tgcgaattgc 8520 tttgaaagga aaatggcctt tcacgtacct tagctatatt gaatgattaa aacaagtaaa 8580 agatataaaa aaactggttc tttttttgat gcttaaagac ttttttactg aacacaaagt 8640 cgaattgcca ctacggtacg atatccttgt tacggtagcc tcaacattta ttcctcttcc 8700 tcaccgccaa catatcctgt tgcgtgtgcc atttcaacaa caatgtctta tgaggattgt 8760 aagttactaa taaagtcatt tttaacacca taatagatca atacaatgag acattgactc 8820 aggaggattg ttggaccgtg atctcgtcgt tttttgagga aacgtcgtta gctcggcaac 8880 aattgttctc tttcgatgag tttgttcaaa atactatgca agaaattgtt gatgatgatt 8940 ccactttaac tctagatcaa tatgcacaac acacgggtgc tcaaggagat gttacacgtc 9000 gatacgaaat aaattttgga cagatttatc tttcaaggcc tacaatgact gaagctgatg 9060 gtagtacaac tactatgttt cctcaagagg cgaggcttcg taacttgact tactcgtctc 9120 ctttatacgt tgacatgcgt aaaaaagtta tggttgctgc cgattctaat gttcccatcg 9180 gcgaagagga gtggcttgtt gaagaagagg atgaagaacc ctcaaaagtt tttattggaa 9240 agataccaat catgctccgt tctacttttt gcattttaaa tggtgttagt gattctgaat 9300 tgtacgattt gaatgagtgc ccttatgatc agggaggata ctttattatc aatggctctg 9360 aaaaggtaat cattgctcaa gagagatctg ctgccaatat tgtacaagta tttaaaaaag 9420 ccgctccgag ccccatcgct tacgttgctg aaattcgctc tgctttggaa cgaggtagta 9480 ggcttatttc ttctatgcag attaagttaa tggcacgtaa tactgagaat tctggtcaga 9540 caattagagc aacacttcca tatatcagga gtgacattcc tatcgtcatc gtgttccgtg 9600 ctcttggagt tgtacctgat cgtgatattt tggaacatat atgctacgac ccaaatgatt 9660 tccaaatgct tgaaatgatg aagccctgta tcgaagaagc atttgtgatt caagataaag 9720 atatagcttt ggattacatt ggtaaaagag gcagtactac tggtgttacg cgtgaaaaac 9780 gtcttcgata tgcccatgac attttacaga aagagctgct tccgcatatt actacaatgg 9840 aaggttttga gactagaaag gcgtttttct taggttacat gatccatcgt atgcttttgt 9900 gtgcgttaga gcgtcgtgaa ccagatgatc gagatcattt cgggaaaaag cgtcttgacc 9960 ttgcaggtcc attacttgca tctctgttcc gtatgctctt tcgtaaaatg actcgcgatg 10020 tgtataagta tatgcagaaa tgcgttgaaa caaatcgtga attcaacctt accctggctg 10080 tgaagtcaaa cattattacc aatggtttac gttattcatt ggctactggt aattggggag 10140 accaaaaacg cagtatggtt aatcgggttg gtgtatcaca agttcttaac cgatatacat 10200 tcgcttcaac tttatcacat ttaagacgta caaatactcc tatcggtaga gacggaaaat 10260 tggctaaacc ccgtcagttg cacaacacac actggggtat ggtttgccct gctgaaacac 10320 cagaaggaca agcttgcggc ttagtcaaaa atttgtctct aatgagctat gtttccgtag 10380 gttcacccag tgctccaatt atcgagtttt tagaagaatg gggtttagaa acactggaag 10440 attacaaccc ttcagcgtct cctaatgcaa caaaggtctt cgtgaatggt gtgtggttag 10500 gagtacatcg tgatccagct catttaacag agacgctacg cagccttcgt cgtagattgg 10560 acatatctgc agaggttagt atcgttcgcg atatccgtga aaaagagctt cgtctcttta 10620 cagatgcagg tcgtatttgt agaccattat ttattgtgga taacaatcct aatagtgaaa 10680 gaagaggaga gttatgtatt cgtaaagagc atatccaaca actaatagag gataaagaca 10740 gatatgacat tgaccccgaa caacgctttg gatggaccgc tttagtatct agtggtctca 10800 ttgagtatct agatgcagaa gaagaggaga cggttatgat agcaatgagt ccggaagatc 10860 ttgaagcatc acgtcaaatg caagctgggt atgaagttaa ggaagaactg gatcctgcac 10920 aaagagttaa gccagctcct aatcctcatg tgcatgcttg gacc 10964 //