ID SPAC513 standard; DNA; FUN; 13204 BP. XX AC AL122032; XX SV AL122032.1 XX DT 19-OCT-1999 (Rel. 61, Created) DT 16-NOV-1999 (Rel. 61, Last updated, Version 4) XX DE S.pombe chromosome I cosmid c513. XX KW alpha-mannosidase; cinnamoyl-coa reductase; KW dimeric dihydrodiol dehydrogenase; eft2; elongation factor 2; KW m-factor precursor; mfm2; oxidoreductase family. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-13204 RA Seeger K., Harris D., McDougall R.C., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (18-OCT-1999) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; O14460; O14460. DR GOA; P34069; P34069. DR GOA; Q9UT60; Q9UT60. DR GOA; Q9UT61; Q9UT61. DR SPTREMBL; Q9UT59; Q9UT59. DR SPTREMBL; Q9UT60; Q9UT60. DR SPTREMBL; Q9UT61; Q9UT61. DR SPTREMBL; Q9UT62; Q9UT62. DR SPTREMBL; Q9UT63; Q9UT63. DR SWISS-PROT; O14460; EF2_SCHPO. DR SWISS-PROT; P34069; MFM2_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c513 is overlapped at the 5' end by plasmid pYUK71, CC EMBL entry SPAPYUK71, accession number AL109734. XX FH Key Location/Qualifiers FH FT source 1..13204 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c513" FT /map="IL" FT misc_feature 1..102 FT /note="nominal overlap with small insert clone SPAPYUK71, FT EM:ALL109734 S. pombe chromosome 1" FT CDS complement(1..190) FT /db_xref="GOA:O14460" FT /db_xref="SWISS-PROT:O14460" FT /label=eft1 FT /note="SPAC513.01c, len:63" FT /partial FT /gene="SPAC513.01c" FT /gene="SPAPYUK71.04c" FT /product="elongation factor 2" FT /gene="eft1" FT /protein_id="CAB58724.1" FT /translation="MVAFTPEEVRNLMGKPSNVRNMSVIAHVDHGKSTLTDSLVQKAGI FT ISAAKAGDARFMDTRADE" FT CDS 1680..2330 FT /db_xref="SPTREMBL:Q9UT63" FT /label=SPAC513.02 FT /note="SPAC513.02, len:216, SIMILARITY:Schizosaccharomyces FT pombe, YA03_SCHPO, hypothetical 24.7 kd protein c5h10.03 in FT chromosome i., (219 aa), fasta scores: opt: 479, FT E():1.1e-24, (35.6% identity in 205 aa)" FT /gene="SPAC513.02" FT /product="hypothetical protein" FT /protein_id="CAB58725.1" FT /translation="MASKGIDKTIYFVRHGQVSHDVDENGVHREHDPLLNDEGRKQALQ FT LQHDLDAEKLPIELILVSPMRRALETMKIGFQHYIEDKHIPVKVIPLLQDCGDWACNVG FT SYTKDLEKQFPGYDYTACHEDPVFPKKEKIYKADYKTSIQRSRVLAEFFAKVPEKVFAV FT VTHGVDIRLFQKIQKPEDSLDAVPKEHSFSPCQHEEFRMHYEDDKNWNFEPVK" FT CDS join(complement(3024..3145),complement(2969..2981)) FT /db_xref="GOA:P34069" FT /db_xref="SWISS-PROT:P34069" FT /label=mfm2 FT /note="SPAC513.03, len:44" FT /gene="mfm2" FT /gene="SPAC513.03" FT /product="m-factor precursor 2" FT /protein_id="CAB58726.1" FT /translation="MDSIATNTHSSSIVNAYNNNPTDVVKTQNIKNYTPKVPYMCVIA" FT misc_feature complement(2982..2997) FT /note="ctaattcaatatatag, splice branch and acceptor" FT misc_feature complement(3018..3023) FT /note="gtaaga, splice donor sequence" FT CDS 3364..3666 FT /db_xref="SPTREMBL:Q9UT62" FT /label=SPAC513.04 FT /note="SPAC513.04, len:100" FT /gene="SPAC513.04" FT /product="hypothetical protein" FT /protein_id="CAB58727.1" FT /translation="MTAKMAEPLYFRIWSSLNIICLMVTFLNVQLSKTPIVLMPLFIAL FT LKNNRKRETKKQTISVLVQKREEKTKLVLDDANNHNHAFLYHCQYLGQKKHVVIQ" FT CDS 4862..8095 FT /db_xref="GOA:Q9UT61" FT /db_xref="SPTREMBL:Q9UT61" FT /label=SPAC513.05 FT /note="SPAC513.05, len:1077, SIMILARITY:Emericella FT nidulans, O13344, alpha-mannosidase., (1049 aa), fasta FT scores: opt: 3253, E():0, (48.2% identity in 1057 aa)" FT /gene="SPAC513.05" FT /product="probable alpha-mannosidase" FT /protein_id="CAB58728.1" FT /translation="MTLFPVLNNTPVGKQVDSIYESRLDQFLSEGQYRDFNLPSVYDHA FT RIDNPSGDVNNDLSKGFVDLKVYRVPDLSRPSFNEVVGHKKFDETASKGDTFGPSWATF FT WFEVHIRLPKSWAKYEQVIFQWNCDNEGLVYSQDGVPLQAFSGSERTDFILPDSWKTTE FT DTFYIEMACNGMFGTGAGSQIAPPDPNRYFTLTKADLVAPNLPAMALAYDFLLMQQCVK FT QLPSNCWQKYKARQICNDIMNTFHPNDLSTINECRNLAKAFLGNDIDSEAVFEKNNDKA FT NVFAIGHCHIDTAWLWPFAETRRKIVRSWATQMNIMDRYPEYQFVCSQALQYLWLKEDH FT PDVFEKLKEYVNQNKFIPIGGSWVEHDTNIPNGESLIRQFLLGQHFFEKEFGVRCRTFW FT LPDTFGYSSQIPQICRLCGMDRFLTQKLSWNNINSFPTSTFNWVALDGSQVICHMPPAN FT TYTADTNVNDVLHSIDQHKNLVNDQAGLLVFGIGDGGGGPTPEMLEKLRRCKGIANTVG FT YLPNVKLGNTVDEFFDGILKRTNAGQTLPSWNGELYFEFHRGTYTTQAELKKLMRKVEI FT ALHDAEYVSTLASIFSKDYSYPKESLQDLWRDTLLCQFHDVLPGSCIEMVYKDAIPIMS FT KVLKNTEALLWQAIEQLGFKKASSSDNKEQLCLLNTLPWNVRGVITETEENKLVYFESC FT DGKGILTAAHTSLKHPAAAYQKDDNFILVNDHLRVTIAPNGLILSLFDLHKEREILDLK FT SGKNHAGANQYVLFEDTPLSWQAWDTEVFSLEKYEVLDKGKVSIKESGPLRASVVVDIP FT ISELSHMKATISLEGYNDCSEFTGVNFTCEVDWHESCKFLKVEFPVDIHSEFASYETQF FT GITKRPTHYNTSWDVAKFEVCHQKFADYSDFTYGVSVLNDCKYGFSTHGNLMRLSLLRS FT PKQPDAHADMGKHTIRYAVYPHSKPLDSSTVRAAHKFNSNFRLLTRASDTANLDIFDAF FT QLVGEPNVILSHIKMAEKGKSIILRVYESLGGKSRARLVIKSLTVASVTKCNGLEEDLE FT ELCTLKSNDYYEVPIELRAFEIATFKVNL" FT CDS complement(8323..9429) FT /db_xref="GOA:Q9UT60" FT /db_xref="SPTREMBL:Q9UT60" FT /label=SPAC513.06c FT /note="SPAC513.06c, len:368, SIMILARITY:Sus scrofa, FT BAA83486, dimeric dihydrodiol dehydrogenase, (335 aa), FT fasta scores: opt: 461, E():4.3e-25, (33.3% identity in 360 FT aa)" FT /gene="SPAC513.06c" FT /product="probable dimeric dihydrodiol dehydrogenase" FT /protein_id="CAB58729.1" FT /translation="MTSMSGASPVIHWGFLGAGSIAAVFAKDLVGVPERHKVQHEIVAV FT ATRDSEHRASSFAKNHCAPCKPKAYGSYEELVKDDKVDIVYISSTHPQHYEVVKLALLN FT DKAVLCEKPLTINYPEALELVELARARNLFFAEGFWIRFYPIVKAAKTLLHEDRVCGDH FT FRLFVDFSQDFRFRELPSESRLRTVSLGAGVLLDMGVYPLTWSRLLLYDDPKNEKQEPT FT VSSNALTFEDHNGDIGDYTTAVTLVFPKTESIAMLCTSMDRGKMSDDFLKLDGENGNQL FT FISGDCYRPQSIKLIRASGETEVFDFSFDDATGFFYEQDAVAECLLKNMKEAPEIPHEE FT TLKMMQLTDQIRRQINVTYPADLRYTTA" FT misc_feature complement(8611..9399) FT /note="Pfam match to entry PF01408 GFO_IDH_MocA, FT Oxidoreductase family," FT CDS 11529..12539 FT /db_xref="SPTREMBL:Q9UT59" FT /label=SPAC513.07 FT /note="SPAC513.07, len:336, SIMILARITY:Schizosaccharomyces FT pombe, O94563, putative cinnamoyl-coa reductase., (336 aa), FT fasta scores: opt: 727, E():0, (39.8% identity in 337 aa)" FT /gene="SPAC513.07" FT /product="putative cinnamoyl-coa reductase" FT /protein_id="CAB58730.1" FT /translation="MSGKLVLVTGVTGFIGAHVAEQLLQAGYRVRGTVRSMEKADELIR FT LNPGLKDKIEFVIVKDVSASNAFDGVLKDVELICHIASPFFVENVTDNKSQLLDPAVKG FT TLGILEAAQGVKSIKRIVITSSFAAVGNFQIDPHNNKVYTEKDWNPITYEEALTTDNGI FT VAYCASKKLAEEAAREYVKEKKPSYDICTINPPYVYGPPIHPMKNMDSLNTSNQIFWKL FT IDGSKEATPFYYYYVDVRDVAAAHVFALENAKLSNGRMLVSKGVFTTGDICKVLRKEFP FT NKSDVIAEPVDITVDPSFFKLDNSFSKSLGFKYHSDEECYVDTAKKLWERAEEFK" XX SQ Sequence 13204 BP; 4255 A; 2313 C; 2349 G; 4287 T; 0 other; gttcgtcagc acgagtatcc atgaaacgag catcaccagc cttggcagca gaaataatac 60 cggccttttg aaccaaagaa tcagtcaacg tagacttgcc gtgatcgacg tgagcaatca 120 cagacatgtt acggacattg gatggttttc ccatcaaatt acggacctct tcaggagtga 180 acgcaaccat tttttagaga tttttaaatg tcagtggcgg acgaaacaat ttcaaacaca 240 ccaagtcaaa ttgatattat agtctgaaac cctaaccctg tgttttttgc gatttattgc 300 gttgcagtat tttaatcgtc gttataataa tgcattaagt gaaatttaaa ttaaaagaaa 360 atacctattt gagaattaga gagggattac atgactagga aggttgagtt ttaaagtcat 420 tctctcttat ttcaagtttt tgtttagtgg gtaattgtgc ttttctggct taaaaataat 480 ctttgttgta caaactgctt tggatctttt attaaagatt ggtgattttc gaataagtaa 540 tttttaaata catttattat tctgctttct gtgacaatgt accaaggatt aaaacatctt 600 gacacagcaa atctaaatac taaaagtacc taatttttga agtctaaggc tgtgctcagg 660 gcctaagatt aatggtttca tttagaaaaa tttaatgaca gttgaatatt tgttaaattc 720 aatgaaattt tattcaccga ttaacttgcc ttacaaagac ttcataccaa atgatgttga 780 aaaaaatggt tcaagctagt aaatccaaat caattgaaag attctgcttt tagaaaggcg 840 taaaaaggct tcttctaagg tacccagctt caccctatac taattttagt aaattacttg 900 cgtgagcctt cataataaat actaggaaat tcacttacat aatgcataat tatttaattg 960 aaagcttaaa ttcatattcc agtagcatat tatatacaaa tatacaagca ttcttcctct 1020 tggaaattga ggatactcta taatagcgaa agaaacctgt caggcataac agagtataat 1080 cccatactgt gtggtaatta aaacaataat attttacaaa tattgatcaa ttactaaaaa 1140 aattaaataa aataaaattt ggaacgtgag gttattagcc ttcctaaaac aaaactaagg 1200 ttgttatatt agcgaagact ttaaagcttc gctagttagt ttaagtactg aatatattag 1260 atgtcattaa aaagttacaa aggaaaacag tttctttatt tctcctagat atagtgaata 1320 attgaatata catagcacta aggattgcta tacaatcata tgaaaatttt cgggttcgaa 1380 gatgttctgt taaatacagc atagcatcat tcttacgtta aaacatgaaa tgacatgcca 1440 aaacgtaaac gacagattcc ggatttggta attgaagaag caaactatct cgatagtgtc 1500 atactcctta ttcggtattt attcttttca tagctctgtc tctgccttat atttgtaggg 1560 ccttcctgca ctttatgatc agtactttca atacttgtaa cactacaata ccctcaattg 1620 ccagcagcgt tattttgtaa gttccttcta ataataaaaa aaagcatttt actcttataa 1680 tggcatctaa aggaatcgat aaaaccattt attttgttcg acatggtcaa gtttctcatg 1740 atgttgacga aaatggcgtt catcgcgaac atgatccttt actaaacgat gaaggacgca 1800 aacaggcttt gcaacttcaa catgatttgg atgcagaaaa gttgccaatt gaactgatac 1860 ttgtttctcc tatgcgccgg gccctagaaa caatgaaaat aggttttcaa cattatattg 1920 aagataagca tatcccagtg aaagttatcc cccttctaca agattgcggc gattgggcct 1980 gcaatgttgg ctcatataca aaagatttag agaaacaatt tcctggttat gactatacag 2040 catgtcatga agatcccgta tttcccaaga aggaaaaaat atataaagca gattacaaaa 2100 ctagtattca acgttcacgt gtcctcgcag aattctttgc caaggtaccc gaaaaggtct 2160 ttgcagtggt aacccatgga gtagatattc gattattcca aaaaattcaa aaaccagaag 2220 attctttaga cgccgttcct aaagaacatt cattttcacc ttgtcagcac gaggaattcc 2280 gtatgcacta tgaagacgat aaaaattgga actttgaacc tgtgaaataa acaacaaacg 2340 gtttttttta tcagcgaact tctctctttg gaatcaagtt attaccattg attataattg 2400 caacttattt cgaatgtgtt gtgcaatttt ttactagcat gtatgtcttt atgaattaaa 2460 gttataataa gtaaggaaat gaaatttaat gtttagataa ctaatcagct tgtgagtaaa 2520 atcccaagta cgtaaataaa taaatagtga aaaccggaaa acatagacat tacaaaggtt 2580 cgtagtgcac gatgctttat atattctgat cattaagaag tctgttgcgt ttgctaatta 2640 gaatacgaaa aaaagcaata aattattcat taataatttg tcgtcttact ttttacacag 2700 tctcttactc atatataagg aagataataa ctgacgaaaa cagaatcata aattaattaa 2760 ttataaaaaa aaaatagcaa aacgatgcaa ttagaaatca caaacattgg aaagttaagg 2820 cacgtgggtt ataaggaaaa gacacatata gtataaaatt gcaaaaagta ttcataaagt 2880 gctttacaag tttgtattcc ctaggaaaaa aatgaataaa atcaaacata aattgctggt 2940 aaaccttggc aaaaagattc cagtttgatt aagcaattac actatatatt gaattagaat 3000 gagtaaatac taacaattct taccacatat aaggaacctt tggagtataa tttttaatgt 3060 tttgagtttt tacaacatcg gtaggattgt tgttgtaggc attgacaatg gatgaagaat 3120 gagtgttagt tgcaatggag tccatgtcta atattgatga aaagaacgta aatagaagtg 3180 tgtattagat gagaagtcaa tataacttga taataattat gtacattttc ccttcctata 3240 aatacctttt gcaaaatgcc aattccccag aaactgtgat ctctttgttc atttgcctat 3300 tgtttgaccc attgtttaat tctggaatag ggatgcctta tgccggtcgc caaaatataa 3360 acaatgaccg caaagatggc tgaaccattg tactttagaa tatggtcctc gttaaacatt 3420 atctgtttaa tggtgacttt tcttaatgta caattgtcaa agacacctat tgtgttgatg 3480 cctttgttta ttgcactatt gaaaaacaat aggaagcggg agacgaaaaa gcaaacgata 3540 agtgttttgg tacaaaaaag agaagagaaa acaaagctag tattagatga tgctaataat 3600 cacaatcatg cgtttcttta ccactgtcaa tatttagggc aaaaaaaaca tgtagtgata 3660 caataaaaac aggtattaca caacactgaa ttttcatata tatcaaaaac attttaccat 3720 aatttttatt attttaatat ttaaaaaaca attttcttta tcttcctgta atacctacgt 3780 ttaagcatcc acttttctat tttccattca taaaatggag aggtatgtta ttcgaaaaca 3840 aaacaaaccg ccgtcgtttg ttacttgttt aaattaaatt cgcgtcgcgt tgtagcgcgc 3900 cgtgttgttg ttgtttaata attcacgaca gaaacttaag aatagtcaag ccatttagct 3960 gctttacaaa tcttgttctt catccataaa actatctttg attcaaatgt ttcttctttt 4020 cacgagaatt tgatactttt ttgtcaatat aatatccctc gcttttcgca aataacgaaa 4080 atgaaaatgc gttttcaatg ctgctgagaa tttttactgt actatatata tgtattaaca 4140 attcactact ttatgaataa tacaatttaa tctcatgata tttgaatctt gtttccgacc 4200 gctaatgaaa tagcaagttc caccttcgct cacggtactt ttgcacatct cggctggcct 4260 tgcgataacc tagttacata gtccaagcac agctccgtca ttatatagac attgggctga 4320 tttttcaact cgtaaaacca cattacatac atcggaatta tgtacctaat aaaggactca 4380 gtttacatca acttcccgaa tttgatgtgt ttgataggaa agctgaacat tcttagtttg 4440 tactacatcc actctaaatt tatcaggtca atttaatgat tagttcgtta ttatttggca 4500 tacaaacttg cttaaattga aacttttcat tcgcggatag acttcttgag gttgaatcgc 4560 attgtttgtt tgttattgta accaacatac tctctattca ttgagatttt ttaagttact 4620 tattctggtc ttatatagtt ttttaagtct tttttaatta ttgaaaaata aacaaagaca 4680 gattaagtct tagccaatct attcttccac gttccgttcc taccaaacgt tttcaattta 4740 aagatcttct gctttcctca gcagtttaag gttgtttgga aatttttcaa acaaaaaaac 4800 atacctaaat tacatatact ttacacctac cgtgctatct tttcagctat agacgattgc 4860 tatgacactc ttcccagtat taaataatac tcctgtcggt aaacaagttg actcgattta 4920 cgaaagtcgt cttgatcaat tcttgtccga agggcagtat agagatttta atcttccaag 4980 tgtttacgat cacgctcgga ttgataaccc tagtggagat gttaataatg atttatccaa 5040 agggtttgtt gatttaaagg tctaccgtgt acccgatttg tctcgtccga gcttcaatga 5100 agtggtagga cataaaaagt tcgatgaaac tgcttccaag ggagatacat ttggacctag 5160 ttgggcaact ttctggttcg aggttcatat tcgattgcca aagtcgtggg ctaaatatga 5220 acaggttatt tttcaatgga attgcgataa tgaaggtttg gtctattcac aagatggtgt 5280 tcctcttcaa gcttttagtg ggtctgaaag aactgatttc atattgcccg attcgtggaa 5340 aaccactgaa gatacttttt atattgagat ggcttgtaat gggatgtttg gaactggtgc 5400 tggcagtcaa attgctcctc ctgacccaaa cagatacttt actcttacca aagctgattt 5460 agtagctcct aatcttcctg ccatggcttt ggcatacgac tttcttctta tgcagcagtg 5520 tgtcaaacag cttccttcca attgttggca gaaatacaag gctcgccaaa tttgtaatga 5580 tattatgaat acttttcatc ctaatgactt atctacgatt aatgagtgcc gaaatctcgc 5640 aaaagcgttc cttggcaatg acattgattc tgaggcagtt tttgagaaga ataatgacaa 5700 agcaaatgtg ttcgcaatcg gtcattgtca cattgataca gcatggttat ggccgtttgc 5760 agaaacgaga cgtaaaatag tccgttcttg ggctactcag atgaacatca tggatcgtta 5820 tccggagtat caatttgttt gctcgcaggc actacagtat ttgtggctca aggaagatca 5880 ccctgatgtg tttgagaagc taaaagaata tgtgaatcaa aacaaattca tcccgattgg 5940 tggtagttgg gttgaacatg acacaaatat tccgaatgga gaatccttaa ttcgccaatt 6000 tttactggga cagcatttct tcgagaaaga atttggagta cgctgtcgga cattttggtt 6060 accagacact ttcgggtatt ctagtcaaat tccacaaatt tgtcgtcttt gtggaatgga 6120 tagatttctg actcaaaaat tgtcatggaa taatatcaac tcatttccta cttctacatt 6180 taattgggta gcattagacg gctcccaagt tatttgccat atgccgcctg caaatactta 6240 tactgctgat accaacgtta acgacgtgtt gcattcaata gatcaacaca aaaatcttgt 6300 taacgatcaa gcaggcttac tcgtttttgg tattggtgat ggtggtggtg gccctactcc 6360 cgaaatgctt gaaaaacttc gtcggtgtaa aggaattgcg aataccgttg gatatttgcc 6420 aaacgtaaag cttggaaata cggtggacga attttttgat ggcatactta aaagaaccaa 6480 tgccggtcaa acgttaccct catggaatgg agaattatat tttgaatttc atcgtggaac 6540 gtacactacg caggccgagc ttaagaaatt aatgcgcaaa gtagagatag cgctgcatga 6600 tgcagaatat gtatctactt tggcttctat atttagtaaa gattattcgt atcccaaaga 6660 aagcctgcaa gacctctgga gagacacctt gttatgtcag tttcatgatg tacttcctgg 6720 atcctgtatc gagatggttt acaaagatgc tattcctatc atgagtaagg ttctaaagaa 6780 taccgaagct cttttatggc aggctatcga acagcttggt tttaagaaag cttcctcttc 6840 tgataataaa gaacagttat gcttgttgaa taccctgcct tggaatgttc gtggtgtaat 6900 cacggaaacc gaggaaaaca agctcgttta cttcgaatct tgtgacggta aaggaatttt 6960 aacggccgct catacgtcgc tgaagcaccc tgctgctgcc tatcagaaag atgacaattt 7020 catattagta aacgaccact taagagttac tattgcaccg aatggtctta tacttagttt 7080 atttgattta cacaaagaac gggagattct tgatttaaaa tctggtaaaa atcatgcagg 7140 agctaatcag tatgttttgt ttgaagatac tcctttatct tggcaagctt gggatacgga 7200 ggttttttca ttggaaaagt atgaagtttt agataaagga aaagtcagca tcaaagaatc 7260 tggtcctttg agagcatccg tagttgtgga tatccctatt agtgaattaa gtcatatgaa 7320 ggccaccatc tcccttgaag ggtacaatga ttgttccgag tttactggtg taaactttac 7380 ttgcgaagtg gattggcatg aaagttgcaa attcttgaaa gtggagtttc ccgtcgatat 7440 tcattctgaa ttcgctagtt atgaaacgca atttggcatt actaaaaggc ctacgcacta 7500 caatacgtct tgggacgttg ctaaatttga agtatgccat caaaaatttg ctgattattc 7560 ggactttacc tacggagtat ccgtccttaa tgattgtaaa tatgggttct ccacacatgg 7620 aaatttaatg aggctctctt tgcttagatc tcccaagcaa ccagatgctc atgctgacat 7680 gggcaaacac acgatccgat atgctgtata tccccactca aaacctctag attcttctac 7740 cgtccgagcc gctcataagt ttaatagtaa cttccgttta cttactcgtg cttctgacac 7800 agcaaatcta gatatctttg atgctttcca actagttgga gagcccaatg taatattgag 7860 tcatataaag atggcagaga aaggaaaatc tattattcta cgcgtttatg aatcccttgg 7920 tgggaaatct cgtgccagat tggttatcaa gtcgcttaca gttgcctctg ttacgaaatg 7980 taatggttta gaagaagact tggaagaatt gtgcacgcta aaatcgaatg actattatga 8040 ggttcccatt gaattgagag cttttgagat tgctacattc aaggtgaacc tttaatatta 8100 tattcataaa gtaccaagag taaagaaaga atatctatct tttcatgata aatgtgcgca 8160 gtagaagtaa acatatttta actaattgtc ttggcttagg tttgcaaagt ttcgtttaac 8220 aactacttat agtactaact gtcacgtcaa attttaaaaa tctttcataa aaatataaga 8280 ctcataaaag cagaaatcca attaagctct ttatcccagc agttacgcag tggtataacg 8340 caaatcagca ggatatgtga cattaatttg tctacgaatt tgatcagtta attgcatcat 8400 cttcaatgtc tcctcatggg gtatttcagg tgcctccttc atgtttttta ataagcattc 8460 agcgacggca tcctgttcgt aaaagaatcc agtagcatca tcaaaggaaa agtcaaatac 8520 ctctgtctcc ccagaagcac gtatcaattt aatactctgt gggcgatagc aatcaccaga 8580 aatgaacaac tgattaccgt tttctccatc caatttaaga aaatcatcgg acattttacc 8640 acgatccatt gaggtgcata gcatagctat ggattctgtt tttggaaata ctagagtaac 8700 tgctgtagta taatccccta tatcgccgtt atgatcttca aaggtaagag cgtttgagga 8760 aacagtgggc tcttgctttt catttttggg atcatcatag agcagtaatc gagaccaggt 8820 aagcggataa acacccatat ctaataaaac gccagcgccc aaagaaacgg tgcgtaaacg 8880 ggattctgag ggtagttcac ggaaacgaaa atcttgtgaa aaatctacaa aaagacggaa 8940 gtgatcacca caaacacgat cttcatgtag aagagtcttg gcagccttta caattgggta 9000 aaaacggatc caaaaaccct ccgcgaaaaa tagatttctt gctctcgcta attccaccaa 9060 ttctagtgct tctggataat taatggtaag aggtttttcg cataagactg ctttgtcgtt 9120 caacaaggca agcttgacaa cttcataatg ctgagggtgg gtcgaactaa tgtaaacgat 9180 atccacttta tcatccttta ccaattcctc atatgaaccg tacgctttag gcttgcatgg 9240 ggcacaatga ttcttggcga aagaggaagc acggtgttca ctgtcacgtg tagcgacagc 9300 cacaatttca tgttgaactt tgtgacgctc tggtacgcct acgagatctt tggcaaagac 9360 cgcagctata cttcctgcac ccaagaaccc ccaatgaatt acaggactgg caccactcat 9420 agaagtcatt ttcaaaactt acgttcaacg aatcaaagga aaattacgat tgtatattat 9480 gagaagaaaa actgaattat atttttccaa ccgtttgttt gacccaagtg tccgttttat 9540 agcaacaaaa agttggagaa ttaagcaaac acagaagaaa ccacagagca aagaagtggt 9600 tatgagttca gtacttatcg aagcttatat acatttacaa ttatgtaagc gtaagtacat 9660 gtgtttccaa tttgcgtgct aaataataag attttcgtta gctatcggga tatcgctttg 9720 aagtcaccac tatgaagtaa atgagtgtca ttaaaaatga ttgactaccg agagtgattg 9780 cttatgaata aaagatcata ttatgacctg aatatgtcta tcacactgtt cactctttaa 9840 taggaatgtt gttaagtagt agattgaaaa ttttgaaact cagtacatct tggaatggtg 9900 gaagtttgaa tacctagaga aaacatgtgc gatagtcgta cacaagttta tggttccaga 9960 atttggtcta acacttggaa tcaagttgtt ttgtcaattc gttacttcta agacaaactg 10020 taaatatact agggttttat cgactaagtc tgtgttttat ccttaaacga aaaattgatg 10080 ggatcatagc gtcaaaggta aaaactatac tacttgggag ttaatccttt gaatatgcat 10140 tcatgaatat gaagttgatt ttttaaattg atccatatca ttcgtatgcg aacgtactgc 10200 tataagaaaa tacttttatt tacagataat attaattatc gtattgcaaa ttccataaag 10260 ctgtatacat atgagatagc gtaaagcgtc atttatcggt ttattatttt acagaattaa 10320 aataattcat gcggtatata ctttgtaacg cttttccacg tgcgttgtta aaaagatgag 10380 atggtagcta taacaaatag acaaaagaag ttaaagatag acgttcattg aaagcatatt 10440 tttttagaaa ctttcaatca aaggagaagg aggaacagga aacaaaaaat aagtcctagg 10500 aataatacgc tagctatgtt caaaattaaa caagttccga aagatttcgt tgcgctgcat 10560 tgcgatatgc tatttgtcct attaaccaaa tgtgtataat cttggctact gtattaaaca 10620 catagttaat tttggcaaaa ggtatttaat atttacaaat actacttggg gataaattca 10680 attgcaaaat taattatttc tattcattca tatagataat aaaatccaac agttcgatta 10740 gttcattaag ctaaactaac gttttcgcct taattagtct actgcgagtc tcttttcaat 10800 accttaaaat aataatcttc atagagcata ccgaatgatg atatttgaga aaggacgaaa 10860 gaggtgggta cggaaatatg tgtatgtaaa gcagaaatcg tatttttaag gtgataattc 10920 catgcagaat tatattcccc gatgtgtatt ccactttact ataaaaaact cactctaagt 10980 ttctcagccg taactagaaa gaaataaaac ccatctaatg ctatccataa atctgaaaac 11040 tgctttttat atctttttac catgaataga atagctgtat gccaaagcgg gatactaaat 11100 ttacacaacc atttattttc attttctttc taatttgtat taacaaaact tttattgctc 11160 agaagcaata gctgaccatt gtttacatcc ctacttcttt actaaatttc cgtattacga 11220 aactctcctg tattcaacaa gttttgtgag acttttacta taatgcgtaa gaaatggcag 11280 aacgaaaact tgagaaagtc aagttatcca tttcacgtca tgttatagcc cattaataat 11340 attatatttg attactaaaa aaatgggaac aatcggatgc gcaacttccg aagaaaaata 11400 tggaacaaat ttttcgttgc ctactcattt tcttatatat tacaaggaaa gtctacttcc 11460 attgtcaaca agtgatattt caggtataat cacttatatt ttttagaaca aacacaaaac 11520 cttcaaagat gagtggaaaa ttggtccttg ttactggtgt tacaggattt attggagccc 11580 acgtcgctga gcagctcctg caagccggct accgtgtgcg tggtacggtg agaagcatgg 11640 aaaaggcaga cgagcttatt agactcaatc ccggattaaa ggataaaatt gagtttgtaa 11700 tcgtcaagga tgtctctgct tctaacgctt ttgacggtgt tttgaaagat gtggaattga 11760 tttgtcatat agcatcacca ttctttgtgg aaaacgttac tgacaacaaa tcccaacttt 11820 tggaccctgc cgtgaagggt actctcggca ttttagaggc tgctcaaggc gtaaagagta 11880 ttaagcgcat tgttattact tcatcttttg ccgcagtggg caatttccaa atcgaccctc 11940 ataacaataa ggtgtatact gagaaggatt ggaatcccat tacctatgag gaggcattga 12000 ccactgataa tggcattgta gcatactgtg cttcgaagaa actcgccgaa gaggctgctc 12060 gagagtatgt aaaggaaaag aagccttctt atgatatttg tacgatcaat cctccttatg 12120 tgtatggtcc accaattcac cctatgaaaa atatggactc tttaaatacc tccaatcaaa 12180 tattttggaa attaatcgat ggatcgaagg aagccactcc attttattat tactatgttg 12240 atgtccgtga tgtagctgct gctcacgttt ttgcccttga gaacgccaag ttgtctaacg 12300 gccgtatgct tgtctccaag ggtgtattca ctactggtga tatttgcaag gtccttcgca 12360 aagaattccc caacaagtcc gatgttattg ccgagcccgt cgatataact gtggatccca 12420 gtttcttcaa gttagacaac tcattttcca agtctcttgg attcaaatat cattccgacg 12480 aggaatgcta tgttgacact gctaagaagt tatgggaacg tgctgaggag tttaaataaa 12540 atgtttacaa acgttgggtt gagcattctt ttgttacgaa ttcatttttg ctccttattt 12600 atttcacgat ttcttctttc aatttatatc gctacgacat atatagactt tagacatatt 12660 aaattattag aatttcattg catttagata aaagactttt ttcgatagtg cttgtcggta 12720 cactttgttg tatacaattt tttcaatatt ttgaaatttt ttactctatc aatcgatttg 12780 cgattttttc tactcttatg atggtatact gcaattgccc ttacagtgta acgaaatata 12840 tctaaccgat atttatttcc gttttttcag tatttacgta agtttctttt tgtaaagcgt 12900 tggaatattt gtttgctctt ttttttgatc tactattgtt acaaaactac caactgttgc 12960 aaaaaaaaat tcataaaact tgacacctta aattgtactt aagtttatac ggcatactgt 13020 actatacttc tgtaacacat tcaacaatat ataaggattt ttcggaactt ttctggagcc 13080 atttttacaa atggtgacgc ttacataatg ccctcgtaaa tgaaatatat attcggcctc 13140 gaactcttct ataatctttt aattttcttg gtctaccttt ttgtcaaaat tcgaagtact 13200 gatc 13204 //