ID SPAC25H1 standard; DNA; FUN; 14220 BP. XX AC Z98944; XX SV Z98944.1 XX DT 02-SEP-1997 (Rel. 52, Created) DT 03-FEB-2003 (Rel. 74, Last updated, Version 6) XX DE S.pombe chromosome I cosmid c25H1. XX KW G-beta repeat; wd-40 repeat. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-14220 RA Devlin K., Churcher C.M., Barrell B.G., Rajandream M.A., Wood V.; RT ; RL Submitted (14-AUG-1997) to the EMBL/GenBank/DDBJ databases. RL Schizosaccharomyces pombe chromosome I sequencing project, Sanger Centre, RL Hinxton Hall, Hinxton, Cambridge CB10 1RQ E-mail: barrell@sanger.ac.uk XX DR GOA; O14154; O14154. DR SPTREMBL; O13977; O13977. DR SPTREMBL; O13978; O13978. DR SPTREMBL; O13979; O13979. DR SPTREMBL; O13980; O13980. DR SPTREMBL; O13981; O13981. DR SPTREMBL; O13982; O13982. DR SPTREMBL; P78890; P78890. DR SPTREMBL; Q9Y825; Q9Y825. DR SWISS-PROT; O14154; AMY3_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPAC5H10.01c. CC SP (S. pombe), A (chromosome 1), c5H10 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c25H1 is overlapped at the 5' end by cosmid c23H3 and at CC the 3' end by cosmid c4A8 XX FH Key Location/Qualifiers FH FT source 1..14220 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c25H1" FT /map="IL" FT CDS complement(<1..261) FT /db_xref="SPTREMBL:P78890" FT /gene="SPAC25H1.01c" FT /gene="SPAC23H3.15c" FT /product="hypothetical serine-rich protein; sequence FT orphan" FT /protein_id="CAB11598.1" FT /translation="MSYQQRANDSMNSAKQYSSSAGAVHNSDEPFSSSGAPQNRNFDTS FT YTSEIPSNSSRAANDMGTDIGSGDPYAGMTSDTKKGFNSVES" FT misc_feature 1..494 FT /note="nominal overlap with cosmid SPAC23H3, EM:Z99163 FT S.pombe chromosome 1" FT CDS 1572..2966 FT /db_xref="SPTREMBL:O13977" FT /gene="SPAC25H1.02" FT /product="JOR domain; possibly chromatin associated (Koonin FT et al); no apparent S. cerevisiae ortholog" FT /protein_id="CAB11599.1" FT /translation="MVYRPTAHEFDDLPKIEFIDSCPYQVFLEQYLKPCVPVLIGPKLT FT AQWKANTTWITSKGDPNILHSYILPDKPCTSRDNTSGNSLLNDNDIKNFIRSYAERIVN FT NEDKNVFLDSLLLSPNYEYLEENYGTIPVPLAYCNEKDRYGSQRRETVPLKSALHELRD FT EQVQLQCRQAPSNQALKSLYAKDMHLFRHLDPADFPYSTPDIFADDWLNAYVIDCESDD FT FRFAYLGSHLTTTGLHTDVYASHSFSVNLCGVKCWLFIDPKDLQTIASLYDDQQLPSWI FT TKDDLFRGPLVNHRHLIKILFQYPGQTVFVPSGWYHQVLNIGTTLSINHNWCNASCILQ FT MYTALKEQYEVSAESLKDLLEDGIVTKDRFSQVVTEVVEANYGWCWRRFWGMIKHQLKR FT RDAILHSSEYFSKWPIQPEFLPPLSWEYSILKNILLNDEPGSTFDSGSPPSSIVTIFKS FT LGDFKE" FT CDS join(3693..3756,3809..4299) FT /db_xref="SPTREMBL:O13978" FT /gene="SPAC25H1.03" FT /product="hypothetical protein; low similarity to D. FT melanogaster CG7053 and human CDNA FLJ11773; no apparent S. FT cerevisiae ortholog" FT /protein_id="CAB11600.1" FT /translation="MTNTVTIELKIGYKYAAEVVKAVLGVILFHRQFSTVPARTIDVLD FT ITVPTLVGAELNEQLATKAAEFIDTIRNEAGANGQMILLLYERSPKKSWFGKGNTIPWE FT QWILHTTILEEGDSYQESSLSLEAAVEQIVQAVNLRSLSYLPPVAMDSGNYPYEIVTPT FT STEGWGSLLKRMIIENVSGGD" FT misc_feature 3757..3762 FT /note="gtaagt, splice donor sequence" FT misc_feature 3797..3808 FT /note="ctaatcctttag, splice branch and acceptor" FT misc_feature 4027..4053 FT /note="PS00075 Dihydrofolate reductase signature" FT CDS 4740..5474 FT /db_xref="SPTREMBL:O13979" FT /gene="SPAC25H1.04" FT /product="hypothetical protein; sequence orphan" FT /protein_id="CAB11605.1" FT /translation="MSKCLQQLKRQLQHFGIDGCSLADGDIDYFFTVTGIDRGWGCGWR FT NIQMLISWLQYTNPNWFKRNFSSGNYEINSLQSLLLSAWMKGIDAEGYAQLGDNLHGKW FT IGATEVYSLFTGLFVNVALVDFDFRSEASASNALFLYVKKHFESSNDTSNVSPCYLQFQ FT GHSIIIIGFCSSLETLVVLDPDRYQSVQKKFVNIADFNHCYMRKKRSLKFSQFQLVHFK FT QNIFLNDFSSKLEVRSTRISDF" FT CDS 5793..6446 FT /db_xref="SPTREMBL:O13980" FT /gene="SPAC25H1.05" FT /gene="meu29" FT /product="meiotic expression upregulated; no apparent FT orthologs; predicted N-terminal signal sequence; 2 FT predicted transmembrane helices" FT /protein_id="CAB11601.1" FT /translation="MFVVKTAVLLFFALFIGNTYAYTYSLDRIQALKFSSESSNVDDGP FT RLHCKGPACSSHSNDLAICQHNQLNVAPHLLKWTCVWPNQSSHVEVIDYNIECKKTVAL FT SMDSITKTCILNYKLEWTYSGVLLHRPWKLFSLKPFTAAFVLLLAASYLATACFRMLGY FT LGTPRSRFHDNRRWNEQKFMELAVSAVEEQLSNGIQLFSNVKQRVPVPVLDESV" FT 3'UTR 6447..6859 FT /note="mRNA from AB054313" FT CDS 7108..8334 FT /db_xref="SPTREMBL:Q9Y825" FT /gene="SPAC25H1.06" FT /product="WD repeat protein; putative chromatin assembly FT factor; no apparent S. cerevisiae ortholog" FT /protein_id="CAB11602.1" FT /translation="MNTELDMQNFEHIKFLENQISEDHFRWKKNSKHLYNLLITRTLTW FT PSLSIQWLSAMESITEKAVLKNRLLLGTHAAEGMPNFLQLADLDLPDFNQTILDPVKHY FT NEDTGELGGYSMQHSCKFQISQRILHNGDVNRVRHMPQNPNIIATMSSCGNAYIFDRTK FT YTSMPAEEFLPNISLIGHKKEGFGLSWNRQQNCRLVTAANDSKILEWDLNNFSRDTRCL FT TPVKDFHYDDSPVNDVEYHPHHTNLYIAVNDNGIAFICDNRLQQTCSKTVKASNPLFSV FT RHNPSIATLFALGSEQDLQLWDLRNLNKSVFNTSEDLSDNRLKVPSRLTLGGTSLSWSW FT RHSGRIVSACQEYCYVWNFNKANPLEFVHAGHKGTVNEVDFDPFEAQCIASVADDNELH FT IWKPNVIVN" FT misc_feature 8194..8313 FT /note="Pfam match to entry PF00400 WD40, WD domain, G-beta FT repeat," FT CDS 9476..12133 FT /db_xref="SPTREMBL:O13981" FT /gene="SPAC25H1.07" FT /product="conserved protein; similar to S. cerevisiae FT YCL045C; predicted N-terminal signal sequence" FT /protein_id="CAB11603.1" FT /translation="MLRPLWPLFLTALFLNIYRAASVLIDEAGKNDFEISLLGKVNDLV FT YDTKNEYLYAVSQKGLLAKLNASNGDVIWRQSIAPETSQLNYNPVTNFIITVDKDYLYI FT WNSKNGILDRKIELADGKGKLFEVNKGFVYLNPHTRKFIELDLQASFSISIERDLQLDA FT ISFLTYAEKNYVLFKRDGQFVLQALDHNYAVYGPETVLNVPENAQLLVTEKDVIIYSSN FT GVIYGIHVSMADISQLLIDEYKTFEWSSIPGKRHGYSITVDSQSTPVTYLFVIIDSEFV FT LIDEYIHEDTEALGYIHMEDNQTFSRVFAVANQIKFAPATVITIPNQLSRPVFRLFTFA FT EGEISAIVILDDGTFFSFSNTELVWKREEALAYAINPSILPTTLLTSYQKSIQDEENSS FT VSFLNRWYRHFNQLIDFLKHPHGFTSSSVLDDAFTTKIIIPTSTGSIFCLSSDPKQVHR FT ILWRYDFNINPESVESWLLDISDEDPKFAFVHQWNDAFSFYILNASDGSVISQKSRDFK FT ADEFYYVDNISKNLPNQIFAVKDYKVLPLTGDNSIFEKISQEANSIFVYTSETKVEGFS FT ISADLTMDVQWSYNLAEGEIVIASIRRNPHEIVASFGRVLQNREVMYKYLNPNLFALFS FT KCKNDLVVYVMDSVTGSIVYQNKHQGIILFDKVYGVFSENWLVYSYQSDVPNLSTKIIS FT VELFEGSHSNEKIDSNEIYSRHNDYRPYAFTKAYIFDREITTLGVTNTPQGITSRDVLL FT GLSSNQVAMIPQALLSPMRPVLRPNEKANDASFIPYEPIIPLNDDMVLSYNKRVYGVSQ FT ITSGITNFESTTLVLSTGLDVFFTRTAPSMPYDMLSSHFDKKQLMLTTFGILLAVLLTK FT PLVKKKQLNTKWYN" FT 3'UTR complement(12260..12355) FT /note="mRNA from AU007971" FT CDS complement(12356..13555) FT /db_xref="SPTREMBL:O13982" FT /gene="SPAC25H1.08c" FT /product="WD repeat protein; similar to S. pombe pop3 FT (paralog)" FT /protein_id="CAB11604.1" FT /translation="MAEEEENQELYIAENEVEEVIKDNDKLMDQGVTEDEAEQEQNDTM FT NNMVMDMSVQGFFEHKDSVFSVSINPVHSNLCASGGGDDLGYIWDITTGEQICQLTGHK FT DSIVAIDWSFDGTYIATGGMDSQVRLWKSSTGFEFITAFETVDEIVWLSWHPKGLFLAA FT GCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFIPPGVGKRLATVDDSGTLIVWNPATG FT APECRMSSDDHRFDPGNEETAAGWTSFDCNAEGNVLFLGGSSGKVKVVNINSSHILASL FT EAQTESVEAIALCTALPICACASVDGTVALYDSASLKFRKSLPHEQAVIDCKFLPNTPY FT LLTACADCVIRKWDVRSGQLLGEYTGHQEPILCMAITPDGKRVVTGSDDTELLVFDCEH FT " FT misc_feature complement(12368..12484) FT /note="Pfam match to entry PF00400 WD40, WD domain, G-beta FT repeat," FT misc_feature complement(12902..13024) FT /note="Pfam match to entry PF00400 WD40, WD domain, G-beta FT repeat," FT misc_feature complement(13160..13276) FT /note="Pfam match to entry PF00400 WD40, WD domain, G-beta FT repeat," FT misc_feature complement(13286..13402) FT /note="Pfam match to entry PF00400 WD40, WD domain, G-beta FT repeat," FT 5'UTR complement(13556..13584) FT /note="mRNA from AU012110" FT 5'UTR 13757..14115 FT /note="mRNA from AU007561" FT misc_feature 13900..14220 FT /note="nominal overlap with cosmid SPAC4A8, EM:Z98762 FT S.pombe chromosome 1" FT CDS 14116..>14220 FT /gene="mde5" FT /gene="meu30" FT /gene="SPAC4A8.01" FT /gene="SPAC25H1.09" FT /protein_id="CAD62442.1" FT /translation="MKHNEVFGWTLKVLSFLLVVIPANALDKHGWRKQS" FT misc_feature 14116..14220 FT /note="SPAC25H1.09, see SPAC4A8.01 for full length mde5" XX SQ Sequence 14220 BP; 4406 A; 2595 C; 2450 G; 4769 T; 0 other; tgactcgaca ctattgaatc ccttcttagt gtcgctagtc attccagcat aaggatcccc 60 ggatccaatg tctgttccca tgtcgttagc agcacgacta gaattgctgg gaatttcaga 120 tgtgtaagag gtgtcaaagt tgcgattttg aggggcacca ctagaagaga agggctcatc 180 actgttgtgg acagcaccag cgcttgagct gtattgctta gcagagttca tagaatcgtt 240 tgcacgttgt tggtaagaca ttttatgaaa atatttgtag tattgtaagt agaataatat 300 ttacttttca agattcgaat ttattttgcg aatatcgatg gaggaatatc cctatttata 360 aataaaaaaa cctttctcca tttatgaact gttgcaaagc actgacgaat ttcttcatca 420 tgcaatgtgc gttttcttta tttgatcgcc actcttgaat taaaccacgt acgacaactt 480 tcttcacttt gatctctaag ttccctctgt taacaaattg gcatgatcga tttcagcctg 540 ctgatatcac tatttacaga tcttccaata ctaaccatct gcgtcataca tcactagcat 600 tttggtggtg aacttggtta cagttcgaag tgcgtagcga gaaatgacga agtcagttat 660 tgtcataatt atgtatgaag cttgttgggg attccattta caaagtgtat gtttagcgaa 720 tgtaaacacg ggttaccagt agaaaaaaaa attttatgaa atttcttcaa taatggtttt 780 tttatctcca ttctatttca ttagaaattt ttttttttgc tttatttcca ttctttgttt 840 ttattttttt ttttattttc aatattacta taaattctca ttttataaaa atagattttg 900 caacagtaaa acttggaccg agttgatgat gtctacactt gtagtatggc tttttaaaaa 960 aaaaaaaaaa aaaagataat aattatcatc cttacttcct cgaaagtata gataaatctt 1020 tgcgttcaca ttcagtgtat aatctaatgt ttacctctgt gattcttatt taacttgtaa 1080 accttggtac gggcatatta tctcgctcgt ttcctgaatg tctgagttta aatgatagat 1140 atccgatttc tgctttattt ttatttttat tcttgcattc agttaaataa attaatttta 1200 ttatttggta gttttcataa acttttggca aacaaataca cactccaata aatatactca 1260 ctctctgtag cgtaaggagt actcacctta tctgactatc tgatgctatt ttcatatgaa 1320 aattgaggtc agacggtaaa tagcattttc cattcttctt atcccttctt tttttttttt 1380 ttttttttac ttaacaccaa cttcgtgatg tcgtgatcca tcatccattt atccttccgt 1440 aacctcagtc aatttatcat cgtcatcgta tagctacacc cgctggtcat tttactagcg 1500 aaaaaacaac attttgttac gtaaattaca tatacacttt ctccactaaa tgaatcatca 1560 agttcatcac gatggtgtat cgtcccactg ctcatgagtt tgacgactta ccgaaaatcg 1620 agttcataga ttcatgccca taccaggtat tccttgagca gtatctaaaa ccttgcgttc 1680 ccgtacttat tggaccgaag cttactgctc aatggaaagc aaatactacg tggataacta 1740 gtaagggtga tcctaatatc ctgcatagtt acattctacc tgacaaacct tgtacttcta 1800 gagacaacac tagtgggaat tcactactaa acgacaatga tataaagaat ttcattaggt 1860 catatgcaga aaggattgtg aataatgagg ataaaaatgt gtttttggat tcgttattgt 1920 tatcgccaaa ctatgaatac ttagaagaaa attacggaac gattcctgta ccattggctt 1980 attgcaatga aaaagatcgt tatggatctc aacgtcgtga aacagttccc ttgaagagtg 2040 cacttcatga acttcgcgat gaacaggtcc aactacaatg ccggcaggct ccaagtaatc 2100 aggctttgaa atccttatat gccaaggata tgcacttgtt tcgacatcta gaccctgccg 2160 attttcctta cagtactccg gacattttcg ccgacgactg gttaaatgca tacgtgattg 2220 attgtgaatc cgatgatttc cgtttcgcat atttaggtag tcatttaacg actactggcc 2280 tacacaccga tgtctatgct agccactcct tctctgttaa tctctgcggt gtgaaatgct 2340 ggctttttat cgatcccaaa gaccttcaaa cgattgcctc cctttatgat gaccagcaat 2400 taccttcatg gatcacaaaa gatgatttat ttagaggtcc acttgtaaat catcgacatt 2460 tgataaaaat tctcttccaa tatcctggac aaacagtgtt tgttccaagt ggttggtatc 2520 atcaggtttt aaatattgga actacactct ctatcaacca taattggtgt aatgcatctt 2580 gcattttaca aatgtacacc gcattaaaag agcagtatga agtttccgca gagtctctca 2640 aggatttgct ggaggatgga atcgtaacaa aggacagatt ttctcaggtt gttacagaag 2700 tggtggaagc aaactacggt tggtgttggc gtcgattttg gggtatgatc aaacatcagc 2760 tcaaacgaag ggatgcaata ttacatagtt ctgaatactt ctcaaaatgg cccatacaac 2820 ctgagtttct tcctccatta tcatgggagt attcaatttt aaaaaatatt ttactaaatg 2880 atgagcccgg cagcaccttc gattctggtt ctcctccttc atcgattgtc acgatcttta 2940 aatctctcgg tgattttaaa gaatagtact actcatctaa actcctttta aaatgatgtt 3000 tttttcattc tgcgtctgct ttcttcaatt ttgcttacgt ctttgtatca ttctcatgca 3060 atggtttccc cagacaaata ccatccatat aattagttta ccagtaatat agatagattt 3120 agatatgtaa aataaaaatt aaaaaaatta ctttagtaaa caatatccga gagatgttgc 3180 ttaagttata aatttataat tgatgtatgc tgtaaaaact cttaagacac tggtgtttac 3240 tttaatatac taaaaaaaat tatttaaaaa aatcactatt gatagttcag gttaaaatgt 3300 tgattttctt tagagccagg tcttcggaag tcccttcttg cattttgaac tcacatgtgt 3360 tagtaggaaa ataaacattt acaattatct atcgtcatat ataattctta caattaatcg 3420 ttttctagtt tcaaatacta aaaatattta aattcacaga ctaattggat aattagatgt 3480 ttaaaaaaat gtggacgctt tgcaatgtac aatgcagaaa gtgtttattt acattgagat 3540 tcagaacgag taacacgtta cctaaaaaaa ttggaggacc ctatatatgc acgaacgtaa 3600 tgtatttcac ttgattgacc aagttcaaag ttcaatgcaa gtatcttagt ttgcattcct 3660 caattttact cttccaaaat tttagagatt aaatgacaaa cacggtgaca attgaactga 3720 aaattggtta taagtatgct gctgaggttg taaaaggtaa gtcaaattag ttgctggaaa 3780 tattacatat caaagtctaa tcctttagcc gttttaggtg taattctatt tcatagacag 3840 ttttctactg ttcctgctag gacaattgac gttttagaca ttacggttcc tactctggtt 3900 ggtgcagaac taaatgaaca actagcaact aaagcggcgg aatttattga taccattcga 3960 aatgaggctg gtgcaaatgg tcagatgatt ttactgttgt atgaaagatc gcctaaaaag 4020 tcttggtttg ggaagggaaa tacaattcct tgggaacaat ggatcttgca cactaccatt 4080 ttagaagagg gtgactctta tcaagaatct tctttatctc tagaggcagc agttgagcaa 4140 attgtgcaag cagttaacct tcgaagcctt tcatacctgc ccccagttgc tatggattcc 4200 gggaattacc cgtatgaaat tgtaactcct acttcaacag aaggttgggg ctcactgctg 4260 aagcgaatga ttatagaaaa cgttagtgga ggtgattaaa tcaaatctca ccaggtttgt 4320 acttcaaact tgatttctca ttcagcattt aaaattcttc attcaccata catctatacg 4380 gtttggcgac gcaaagctcc atatgttaac atgttgctgg agaattatgt atcgatggta 4440 tatttacatg ctacttgtaa tcctttcgca attgattatt ttggactaat gaaacttgca 4500 tgcgttaata tagtacattc gcgcatgggt tataagaaag ttggatttag gacggatgct 4560 gtgccattta tatcatgact ttaattgaca gccataattt ttgaaattag cgtttgtact 4620 ttccaaagtt gttttaacaa aatgaccggc gcattcttaa tcgactttta gcttaccgag 4680 atttaacgtg tgaatatttt ttaaatttac tcatttcttt ttacatttcg aaatttacta 4740 tgtcaaaatg cttgcagcag cttaaacgac aacttcagca tttcggcata gatggatgct 4800 cattagcaga tggtgacatc gattattttt tcacagttac cggtattgat cgtggatggg 4860 gctgtggttg gcgcaatata cagatgttaa tttcctggct tcaatacacc aatccaaatt 4920 ggtttaaacg taattttagt agtggaaatt atgaaatcaa ttctttgcaa tcgttgttgc 4980 tcagcgcttg gatgaaaggt atagatgccg aaggttatgc tcaattagga gacaacttgc 5040 atggtaaatg gattggtgct actgaggttt atagcctatt taccgggttg tttgtcaacg 5100 tcgctttagt agactttgat ttcagatctg aagcttctgc tagcaatgca ctttttcttt 5160 acgttaaaaa acattttgaa agttctaatg atacaagcaa tgtttctcca tgttatttac 5220 aatttcaagg gcattctatc attatcattg ggttctgttc ttctttagaa actcttgttg 5280 tgcttgatcc agatcgttat cagagtgttc aaaaaaagtt tgtgaatatt gcggacttta 5340 atcactgtta tatgcgaaaa aagcgatctt tgaaattctc acaatttcaa ttggtacatt 5400 ttaagcaaaa cattttttta aatgatttca gttcaaaact ggaagttcgt tctaccagaa 5460 tttcggactt ttagctgtcc aagcgctggt gatgtttttc ataatattta tgaaggccgt 5520 ttccccatat attaatttat agaaaaagga aaaactgttg aaaaataata atatatctga 5580 ttattctctt ttgacttact actatgtagt atacgtatat ttaaaattgt tgatagtttc 5640 tcatattttc atatagcgac attgttattg aatttaaaat ttgttgtttt gcggtgaatt 5700 cggtgtttac atcggtatat ccgactttgg cttccgaatg tggataaagg ctaaagttgt 5760 taccaaaagt aaacaactac cagccttgca caatgtttgt tgtcaagact gctgtattat 5820 tattctttgc attatttatt ggaaatactt atgcatatac ttattctctg gacagaattc 5880 aagcattaaa atttagttct gaatcctcca acgttgatga tggaccacgg cttcattgca 5940 aaggaccagc gtgtagctcg cacagcaatg atttggctat ttgtcagcat aaccaactta 6000 acgttgctcc tcatttatta aaatggactt gtgtatggcc taatcagtct tctcatgtag 6060 aagtaataga ttataatatt gagtgcaaaa aaaccgtcgc cttgtccatg gacagcatta 6120 ctaagacatg cattttaaac tataagttgg aatggaccta ctctggagta ttactacata 6180 ggccttggaa attgttttca ttaaagccat tcactgctgc gtttgtgctc ctccttgcgg 6240 cttcatatct ggcaactgcc tgtttccgta tgcttggtta tttgggaaca cctagatctc 6300 gtttccatga taacagaaga tggaatgaac agaaatttat ggagttggcg gtttctgctg 6360 tagaggagca gttatctaat ggcatacagc ttttctccaa tgtcaaacag agagttcctg 6420 tacccgtgtt ggatgaatct gtttaatact ttgcatttga atcctcgtgt ttagcttcca 6480 cgtagtatca catatcttaa atggatgaca gtctaactct cagaataggc aaacaacagt 6540 tgaaatcgca cctctgttac atatattaca agttcattcc cttattaatc actcattaat 6600 gaatgcctcc taattgaaat cgagcgctgt catccccacg gctaataatc gttagatttc 6660 tgcattctat ttagtaatat tcttgcatta ttaccatcat attctctgtc cactttcgtt 6720 tgcttcttta acttacagtt agagaaaata cactttaaaa tataataatg gaaaacagct 6780 atattaaaaa tcaatattgg catagcagat cattcatagt attatataac ttcttgatat 6840 aaaattgttt cttttttcat ttatttgttc agctgtatat ggtaatccat atttcgtact 6900 aagcgcttcg tctaccgacg ttgtaggttc aaccttccat gtacatacct tccaacaaaa 6960 ctttcttaca tattgatggc aaatagtggc ttatagacag atattttagt ttaactcatt 7020 ctctaaaagt aaaatcactt gcattctttt gaggtggtag aggtggttta aactcaaatt 7080 gttaaaaatt tgttaaagta tgcaaaaatg aacaccgaac tggatatgca gaatttcgaa 7140 catattaagt ttctagagaa tcagattagt gaggatcatt ttcgttggaa aaaaaattcg 7200 aaacatctat acaacttact aataacccgt actttaacat ggccctcttt aagtatccaa 7260 tggctctcag caatggaatc gatcactgaa aaagcggttt taaaaaaccg tcttctccta 7320 gggactcatg ccgctgaagg gatgccaaat ttcttgcagc ttgcagattt agatttacct 7380 gatttcaatc aaactatatt ggatccagta aaacactaca atgaagatac tggtgagcta 7440 ggaggctata gtatgcaaca ttcttgcaag ttccaaatct cgcaacgaat tcttcataat 7500 ggcgatgtaa atcgtgttcg acacatgcct caaaacccaa acatcatagc tactatgagc 7560 tcttgtggaa atgcatatat atttgatcgg acaaaatata cttcaatgcc cgctgaagaa 7620 tttttaccaa atatctcttt gattgggcac aaaaaagaag ggtttggact atcttggaat 7680 cgtcagcaaa attgccgact tgtaacagct gctaatgatt cgaaaatttt agaatgggat 7740 ctaaataatt ttagccgtga tacgaggtgc ttaactcccg taaaggattt tcattatgat 7800 gattctccgg ttaatgatgt tgaatatcat ccgcaccaca ccaacttata tattgctgta 7860 aatgataatg gaattgcctt tatttgtgat aaccgacttc aacaaacatg ttcgaaaaca 7920 gttaaagctt caaatcccct ttttagcgtc agacataatc cttcaattgc gactttgttt 7980 gctttggggt ctgagcaaga tttacagctt tgggaccttc ggaacttaaa taaatcggtt 8040 tttaacactt ctgaagactt atcagataat agattaaaag tgccttctag actaactcta 8100 ggaggcacca gtttgtcatg gagctggaga cactctggtc ggattgttag tgcctgccaa 8160 gagtattgct atgtgtggaa ttttaacaaa gctaatcctt tggagtttgt gcatgcaggt 8220 cataaaggta cggtgaatga agtggacttt gatccgtttg aggcacaatg tattgcttcg 8280 gttgctgatg acaatgaatt acacatttgg aagcccaatg ttattgttaa ttaataaata 8340 cttacatcca tcacacgagg taatacaaag ttttaagtta tacagcaatt aattaattgc 8400 aattttgatg ggtatgttgc agggctatat tgtattcatt catcttcaaa tttgctcaac 8460 gtgtacatta aaattaccta atgacataga gatatttcat tactaatgaa aagataattt 8520 ttcactcact aatcgtccgt tcggtaatca aggatttcct acttatgttc ttcaatgtat 8580 ttcctataaa gtagtattag taaatatatt ccaaacactc gctatagagc aatagcttta 8640 cttacaaaat gaattcttct tcttctttgc ttttggcatt caaaggagga acatcctttg 8700 cgctaagtgg cttatttctt ttaaacaatt tactatagat cacaggacca acaaatactg 8760 aaccgagaac agctaaactc aactatgttc attgttaggt gtacggaatt tgaaaaatac 8820 atacttgatg agcttggaat tgacgacctg caattgtata aaccgacata atgcttatat 8880 ttaatagtga atgattgaat caagagaagg gaggtaaagg tttaacacgg ttagcagcga 8940 atatgaagcc gactgtaaac ttagcaatca atatattcgt taaattagct taacgaaaaa 9000 taaggaatac agttatcact tcaagtacat ataaaattgc aatagaatca actacatgaa 9060 attaggaagt tagctagctt ttgcctttta tatgaactac ttcaaattag cagataaata 9120 gtaaaaaatg tgattataga cattttgttt gcatttagta cgtttgctaa acgtagagaa 9180 tgtacaggtg tttcacagca aatttttaat taactgacta ttctttttaa atatctaaat 9240 ttttcaatca ttcatcttgc tgcgacattg ctatacgctt tcaaaccata ttgtttagtt 9300 tacagtaccc aatgtgtatt tattgcgaaa agcatcgcta taacagcata ttcttgggac 9360 gcacttcagt aaactgtgtt gtagttcgct actcctcagt atatttgata ccttgcatta 9420 acaataggaa ctatacaggt actggactac ataccatctt ttcatatcag ttacgatgtt 9480 acggcctctg tggcctctct ttcttactgc tttgttttta aacatctata gagctgccag 9540 tgttttaata gatgaagcag ggaaaaacga tttcgaaatt tctctacttg gtaaagttaa 9600 tgacctagtt tatgacacca aaaatgaata tctgtatgcc gtttctcaga aaggcttatt 9660 ggcgaaatta aatgcatcaa acggagatgt gatttggcgc caatccattg cacctgaaac 9720 tagtcaactc aactataacc cagtcactaa ctttattatc accgtggaca aagattattt 9780 gtatatttgg aattccaaaa atggtatttt ggacagaaaa attgagctcg ctgatggaaa 9840 aggtaaatta tttgaggtta ataaaggttt tgtttacctc aatcctcata ctcgcaagtt 9900 catagagttg gatttgcaag cttcattttc tatttcaatt gaaagggatt tacaattaga 9960 tgctatttcc tttttgactt atgctgagaa aaactacgtc ttgttcaaga gggatggtca 10020 atttgttcta caagctttag atcacaatta tgctgtttat ggacctgaaa ctgttcttaa 10080 tgttcctgaa aacgcacaat tattagtcac agagaaagat gttattattt actcttccaa 10140 cggtgttatt tacggtatcc atgtttctat ggcagatatt tctcaactgc ttatagatga 10200 atataaaaca ttcgaatggt ctagtatacc tggtaagaga catggctatt caattacagt 10260 cgattctcaa tccaccccag tcacttacct ctttgttatc attgatagcg aatttgtttt 10320 gattgatgag tatatacatg aggacaccga agctctagga tatatccata tggaagataa 10380 ccaaacattt tctcgagtgt ttgcagtggc taatcaaatt aaattcgcac cagccacagt 10440 aattaccatt cccaaccagc tttctagacc tgtattccgt ttatttacat ttgctgaggg 10500 agaaatttcc gcaattgtaa ttttggacga cggaactttc ttttcatttt cgaataccga 10560 attagtttgg aagcgggaag aagcattggc atatgctatc aatccctcta ttcttccaac 10620 aactttattg acaagctacc agaaatccat tcaagatgag gaaaattcat cggtctcttt 10680 cttaaatcga tggtaccgtc attttaatca actcatagat ttcttgaaac atcctcatgg 10740 ttttacttca tcctcagtat tggatgatgc ttttaccacg aaaattatta taccaacatc 10800 aacaggatct atattttgtt tatccagcga ccctaaacaa gtgcacagga tattatggcg 10860 ctatgatttt aatattaacc cggaaagtgt tgaatcttgg ctattggata tttcagacga 10920 agatccaaaa tttgcttttg tgcaccagtg gaatgatgct tttagctttt atattttgaa 10980 tgcatcggat gggtccgtga tatctcaaaa atctagagac tttaaagctg acgagtttta 11040 ctacgttgat aatatctcca aaaacttacc taatcaaata tttgccgtaa aagattataa 11100 ggttttaccc ttgaccggtg ataactcaat attcgaaaaa atttctcaag aagccaattc 11160 tatttttgtt tacacttctg aaaccaaagt cgaagggttc agtatttctg ctgaccttac 11220 aatggatgtt caatggtcgt acaatctagc cgagggtgaa atagttattg cttctatacg 11280 tcgtaatcct cacgaaatag tggcttcttt cggtcgtgtt ttgcaaaacc gtgaagtaat 11340 gtacaaatat ttgaatccca atttatttgc gttattttca aaatgcaaaa acgatttagt 11400 cgtctatgta atggactccg ttaccggttc tatagtgtat cagaataaac accaaggaat 11460 aatattgttc gacaaagttt atggagtctt ctccgagaat tggcttgttt atagttatca 11520 gagcgatgtg cctaatttgt ctaccaagat aatatcagtt gagctttttg agggatctca 11580 ctctaacgaa aaaatcgaca gcaacgaaat atattctcgt cataatgatt acaggcccta 11640 tgcgttcact aaagcatata tattcgatag agaaattacg actttgggtg tcaccaacac 11700 tccgcagggc atcacctcga gagatgtttt acttggccta tcaagtaacc aagttgcaat 11760 gattccacaa gctcttttga gccctatgcg cccagtcctt agacctaatg aaaaagcaaa 11820 tgatgcgtcc tttatcccat acgaacccat tataccattg aacgatgata tggtgttgtc 11880 ttacaacaag cgcgtgtacg gagtatctca aatcacttct ggtattacta attttgaaag 11940 tacgacgttg gttttatcaa ccggacttga tgtttttttt accagaacag ctccaagtat 12000 gccatatgac atgctcagta gccattttga taagaaacaa cttatgttga ccacttttgg 12060 cattctgctc gccgttctgt taacaaagcc tttggtaaag aaaaagcagc ttaataccaa 12120 atggtacaat taaaaacacc atggagaata aaaatatact tgattagatt tgctacagat 12180 tatataggaa taataattct tggataaaac actagtttac ttgtattact tgtttactca 12240 atagtttaaa aaaaaaatat taatccccat gaatatatat aaattaatat cgaacgcgtt 12300 tatcccataa taataatttt tttttctttt caaaaaatta acctttttaa cacttttaat 12360 gttcgcaatc aaaaacaagt aattcggtgt catcagaacc ggttacaaca cgtttaccat 12420 ctggagtaat agccatacac aagataggct cttgatggcc tgtatactcg ccaagtaatt 12480 ggccagaccg aacatcccat tttcgaataa cacaatccgc gcatgcagtc aacaaatatg 12540 gagtgttggg taaaaactta caatcaataa ccgcttgttc atggggaagg gattttctaa 12600 acttaaggga tgcagaatcg taaagcgcga cagtaccatc gacactagca cacgcacata 12660 taggtaaggc cgtgcaaagt gcgatagctt ctacactttc agtttgggcc tccaaagaag 12720 caagaatatg actactatta atgttgacaa cttttacttt tcctgacgaa cctcctaaga 12780 aaagaacgtt accttcagca ttacagtcga agctggtcca accggcggca gtttcttcat 12840 taccaggatc aaagcgatga tcatcactag acattctgca ttctggtgct ccagtagccg 12900 ggttccaaac aattaatgta ccagaatcat ctacggttgc taaacgcttg ccaacaccgg 12960 gtgggatgaa ttttccagca tttacaggtg ccgtatggcc atacataacc tgaaccacct 13020 taccagaggg aagactccac atccatatac ttccgtcatt acaaccggcg gctaagaaca 13080 agcccttagg gtgccaagat aaccaaacaa tttcgtccac agtttcaaaa gcagtaatga 13140 actcaaaacc tgtactggat ttccacaatc tgacttgact atccatacca ccagtagcaa 13200 tataagttcc atcaaagctc cagtctatag ctactatgga gtctttatgt cctgtcaatt 13260 gacatatttg ttcaccggta gtaatgtccc atatataccc taggtcatct cctccaccag 13320 acgcgcacag atttgaatgc actggattga tagagacgct gaatacagag tctttatgct 13380 cgaaaaaacc ttgaacagac atgtccataa ccatgttatt catagtatcg ttttgttctt 13440 gctcagcttc gtcctctgtg acaccttggt ccattagttt gtcattatct ttaataactt 13500 cttctacttc attttctgct atgtataatt cttgattttc ttcttcttcg gccattatta 13560 atgtgggtgt gtaccagcta aaaagctttg caaaggtcaa gcttagtaag gaaatcagta 13620 tgtatgtaat tttacttagg taataatata ttaattttat tcattatata tacatataat 13680 aaaaataaat aacaaaagta tcttaaaata aaactagttt aattaaatta tttattacgt 13740 ttaaccagtg aatgagtgca agatagtata caaaaatttt caatatttca aaatgctaca 13800 attcatatta gactcaaata tatatagtta taacctaatt cttcataaac aataatcttt 13860 cgtagtaatc cacttcttga agttttcata ttcgtaattg atccaccatc tgtaatagcc 13920 aaataagaat tcctacggcc attattactg gatacgctga attaacgtat gaaatggttt 13980 gtttactttc ttgagcgttt taaagctata aagggaaaga aagtattttt gtttgtttac 14040 aatgaagtaa acaaaaaaaa actacttaag tgacaagcgc aagcaaacac ttctctggag 14100 caactatcat aaagtatgaa gcacaacgaa gtttttggat ggacactgaa ggtgctttca 14160 tttcttttgg tggtaatccc ggccaatgca ttagacaaac atggttggag aaaacaatca 14220 //