ID SPAC19A8 standard; DNA; FUN; 35858 BP. XX AC Z98974; XX SV Z98974.2 XX DT 08-SEP-1997 (Rel. 52, Created) DT 17-FEB-2000 (Rel. 62, Last updated, Version 5) XX DE S.pombe chromosome I cosmid c19A8. XX KW conserved hypothetical; cytochrome p450; ergostrol biosynthesis; KW protein-tyrosine phosphatase; PSU1-like protein; ribonucleoprotein; snRNP; KW tryptophan synthase; vacuolar transport; Zinc finger. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-35858 RA Skelton J., Churcher C.M., Barrell B.G., Rajandream M.A., Wood V.; RT ; RL Submitted (03-SEP-1997) to the EMBL/GenBank/DDBJ databases. RL Schizosaccharomyces pombe chromosome I sequencing project, Sanger Centre, RL Hinxton Hall, Hinxton, Cambridge CB10 1RQ E-mail: barrell@sanger.ac.uk XX DR GOA; O13818; O13818. DR GOA; O13819; O13819. DR GOA; O13820; O13820. DR GOA; O13821; O13821. DR GOA; O13824; O13824. DR GOA; O13825; O13825. DR GOA; O13829; O13829. DR GOA; O13830; O13830. DR GOA; O13831; O13831. DR SPTREMBL; O13818; O13818. DR SPTREMBL; O13819; O13819. DR SPTREMBL; O13820; O13820. DR SPTREMBL; O13821; O13821. DR SPTREMBL; O13822; O13822. DR SPTREMBL; O13828; O13828. DR SPTREMBL; O13829; O13829. DR SWISS-PROT; O13817; SC73_SCHPO. DR SWISS-PROT; O13823; YEE7_SCHPO. DR SWISS-PROT; O13824; NMD2_SCHPO. DR SWISS-PROT; O13825; YEE9_SCHPO. DR SWISS-PROT; O13826; YEEA_SCHPO. DR SWISS-PROT; O13827; YEEB_SCHPO. DR SWISS-PROT; O13830; YEEE_SCHPO. DR SWISS-PROT; O13831; TRP_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe) CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPAC5H10.01c. CC SP (S. pombe), A (chromosome 1), c5H10 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c19A8 overlaps cosmid c32A11 at its 5'end and cosmid CC c23H3 at its 3'end. XX FH Key Location/Qualifiers FH FT source 1..35858 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c19A8" FT /map="IL" FT misc_feature 1..20 FT /note="nominal overlap with cosmid SPAC32A11, EM:Z69796 S. FT pombe chromosome 1" FT CDS complement(1369..3462) FT /db_xref="GOA:O13831" FT /db_xref="SWISS-PROT:O13831" FT /label=SPAC19A8.15 FT /note="SPAC19A8.15, len:697, SIMILARITY:Saccharomyces FT cerevisiae, TRP_YEAST, tryptophan synthase, (707 aa), fasta FT scores: opt: 2877, E():0, (61.9% identity in 703 aa)" FT /gene="SPAC19A8.15" FT /product="tryptophan synthase (EC 4.2.1.20)" FT /protein_id="CAB11651.1" FT /translation="MTEQIKKTFLKAKEENKNVLVTFVTCGFPNVDETIKIMQGLQNGG FT AGIIELGIPFSDAVADGPTICKGNEIALKNNITLEKVFETVKLARDAGVTIPIILMGYY FT NPIFSYGDAKTIQKAKEVGANGFIIVDLPPEEAVGFREECKKQGVSFVPLVAPSTTDRR FT MELLASVADSFIYVVSRMGSTGSSATGVINTALPQLCQRVRKFAGDTPLAVGFGVNTSE FT HFHQVGSVSDGVVVGSKIIDLILKAEPGTAATVVEEYCKYLTKEDPSAPVPKQFQSGGS FT VATAPPAAVVEPINEMYLPQKYGMFGGMYVPEALTQCLVELESVFYKALHDEKFWEEFR FT SYYEYMGRPSALDYAKRLTEYCGGAHIWLKREDLNHGGSHKINNCIGQILLAKRLGKNR FT IIAETGAGQHGVATAICAAKFGMKCTIYMGAEDCRRQALNVFRIRLLGAEVVPVTSGTQ FT TLRDAVNEALKAWVEQIDTTHYLIGSAIGPHPFPTIVKTFQSVIGEETKAQMQEKRKKL FT PDAVVACVGGGSNSIGMFSPFKADKSVMMLGCEAGGDGVDTPKHSATLTMGKVGVFHGV FT RTYVLQREDGQIQDTHSISAGLDYPGVGPELSELKYTNRAEFIAVTDAQCLEGFRALCH FT LEGIIPALESSHAVYGGMELAKKLPKDKDIVITISGRGDKDVQSVAEQLPILGPKIGWD FT LRF" FT misc_feature complement(1411..2553) FT /note="Match to PF00247 , Score 942.36" FT misc_feature complement(2314..2343) FT /note="PS00168 Tryptophan synthase beta chain pyridoxal-pho FT sphate attachment site" FT misc_feature complement(2740..3408) FT /note="Match to PF00290 trp_syntA, Tryptophan synthase FT alpha chain Score 369.92" FT misc_feature complement(3277..3318) FT /note="PS00167 Tryptophan synthase alpha chain signature" FT CDS complement(4051..4668) FT /db_xref="GOA:O13830" FT /db_xref="SWISS-PROT:O13830" FT /label=SPAC19A8.14 FT /note="SPAC19A8.14, len:205, SIMILARITY:Saccharomyces FT cerevisiae, YBF7_YEAST, hypothetical 23.1 kd protein in FT shp1-ptc3 intergenic region., (214 aa), fasta scores: opt: FT 501, E():1.6e-25, (45.5% identity in 191 aa)" FT /gene="SPAC19A8.14" FT /product="hypothetical protein" FT /protein_id="CAB11650.1" FT /translation="MKVPFVNFMISSFPAAVLVGAVVGFMIGRKYSVADASRGYSSKNA FT NKASNPEKESPVSVSNDEDSESETELLDMLKGNSSLAALALAEGQTKMVLVVRTDLGMT FT KGKIAAQCAHAALACYKIASAVDPDLVRIWENAGQAKITLQAQTEETLELLQAQAMSLG FT LCARVIHDAGRTQIASGSATVLGIGPGPVSVINEVTGSLKLF" FT CDS complement(5060..5845) FT /db_xref="GOA:O13829" FT /db_xref="SPTREMBL:O13829" FT /label=SPAC19A8.13 FT /note="SPAC19A8.13, len:261, SIMILARITY:Homo sapiens, FT P78493, 68 kda, (437 aa), fasta scores: opt: 652, FT E():5.1e-30, (43.0% identity in 263 aa) also similar eg. to FT YIL061C, RU17_YEAST, Q00916, u1 small nuclear FT ribonucleoprotein, (300aa), fasta scores, opt:543, E() FT :5.4e-24, (38.0% identity in 266 aa overlap)" FT /gene="SPAC19A8.13" FT /product="putative U1 small nuclear ribonucleoprotein" FT /protein_id="CAB11649.1" FT /translation="MAEKLPAPLLALFAPRPPLRYLPPMDVPPEKRSTPRVSGIAKYLK FT YAQSHDQQYHPTESLEEKRLRLRDEKQKQQRERLRSMIKVWDPDHDRHVIGDPYKTMFL FT SRLSYDTKESDIEREFTRYGPIERIRVVRNKVTGKSMGYAFVVFERERDLKVAYKASAG FT LMLNGRRIVVDVERGRTVKGWLPRKLGGGLGGRHYTKERPRRERGSRFRGDSGFRGGYR FT GGFRKSSGGGSRFGRGPTRSSHSSDYGGRDSSPKRRRYN" FT misc_feature complement(5327..5539) FT /note="Match to PF00076 rrm, RNA recognition motif. (a.k.a. FT RRM, RBD, or RNP domain) Score 79.66" FT CDS complement(6437..8662) FT /db_xref="SPTREMBL:O13828" FT /label=SPAC19A8.12 FT /note="SPAC19A8.12, len:741, SIMILARITY:Saccharomyces FT cerevisiae, PSU1_YEAST, psu1 protein., (970 aa), fasta FT scores: opt: 776, E():0, (29.1% identity in 784 aa)" FT /gene="SPAC19A8.12" FT /product="hypothetical PSU1-like protein" FT /protein_id="CAB11648.1" FT /translation="MSFTNATFSQVLDDLSARFILNLPAEEQSSVERLCFQIEQAHWFY FT EDFIRAQNDQLPSLGLRVFSAKLFAHCPLLWKWSKVHEEAFDDFLRYKTRIPVRGAIML FT DMSMQQCVLVKGWKASSGWGFPKGKIDKDESDVDCAIREVYEETGFDCSSRINPNEFID FT MTIRGQNVRLYIIPGISLDTRFESRTRKEISKIEWHNLMDLPTFKKNKPQTMKNKFYMV FT IPFLAPLKKWIKKRNIANNTTKEKNISVDVDADASSQLLSLLKSSTAPSDLATPQPSTF FT PQPPVESHSSFDIKQKILHLLNEGNEPKSPIQLPPVSNLPLNPPIQSSNSRLSHDNNSF FT DPFAYLGLDPKNPSASFPRVVSQNNMLTNKPVLNNHFQQSMYSNLLKDQNSVQHLFAAS FT DMPSPMELPSPSTVYHQVFYPPTSTSVSSYGLGKTPQPAYGSSSPYVNGHQTQQISSLP FT PFQSQTQFLARNSDNSGQSYNSEGDSNSKRLLSMLSQQDTTPSSSTLSKEANVQLANLF FT LTPNSLETKKFSDNSQGEEISDNLHGESCNNPNANSVHSAQLLQALLHPSATETKEETP FT KKTSDSLSLLTLLKSGLPTPANDLQNKSQNNERKASSQVKELEVKNYSKSTDLLKKTLR FT IPRNDEPLEAANQFDLLKVSPQQKSEVPPKRNELSQSKLKNRKKKENSETNKNHVDMSP FT GFVKILKRSPLADQKKEDTQESDFKGSDDHFLSYLQSVVSSNSNGLH" FT misc_feature complement(8213..8311) FT /note="Match to PF00293 mutT, Bacterial mutT protein FT Score 43.67" FT misc_feature complement(8222..8281) FT /note="PS00893 mutT domain signature" FT CDS join(9059..9116,9157..9546,9589..9780,9824..9924) FT /db_xref="SWISS-PROT:O13827" FT /label=SPAC19A8.11c FT /note="SPAC19A8.11c, len:246," FT /product="hypothetical protein" FT /gene="SPAC19A8.11c" FT /protein_id="CAB11647.1" FT /translation="MRVILVIGRSNSGKLDFIKALTGSLPKGLDDEAFNNDHSGLIHKY FT NIRNKYFEASVGIWIEEYSNLAETLDAYSSEEAKEVIDSLGAIVYTFRSFDEAEWSLFK FT NFIDKLQLEIPVIGLHMSDEKLLEPPDVFTPEYISISEEGVNEFNEKVGLDRVREILDC FT CEWNLSQVDKSFSEEKDDAGDFYLPERFKGSPDMQSTDLDNLMKEMNQIRDADLEKNEK FT KAKALNLLEKLLGDEFEENDYESL" FT misc_feature 9117..9122 FT /note="gtaaat, splice donor sequence" FT misc_feature 9145..9156 FT /note="ctaattgaaaag, splice branch and acceptor" FT misc_feature 9547..9552 FT /note="gtaaag, splice donor sequence" FT misc_feature 9572..9588 FT /note="ttaacaagtctctttag, splice branch and acceptor" FT misc_feature 9781..9786 FT /note="gttggt, splice donor sequence" FT misc_feature 9807..9823 FT /note="ctaacaacgaaatttag, splice branch and acceptor" FT CDS complement(10206..10970) FT /db_xref="SWISS-PROT:O13826" FT /label=SPAC19A8.10 FT /note="SPAC19A8.10, len:254," FT /gene="SPAC19A8.10" FT /product="hypothetical zinc finger protein" FT /protein_id="CAB11646.1" FT /translation="MQFNGSNGIDESSVIDLTRSPSPPVETSISSTNIIDLDAIPDDSF FT PSSPVLSPRRRRMNRRRNERSRNFPSNHLSYLEDMIYLGPQVSTRRSSSRRDLMGMIAR FT TFPEFSSVNSLSPSLFQLIVNRMRFDAIHPEWTNGSDDEYFSNHFEESYDDFTSSLENI FT KQSYKPPGPPKSGFTRSFNNDTLMVCPRCQEPLGTSKSKEKSALWATKCGHVYCGSCAK FT VLKTSKRSQSKCLVNDCGRYLNTKNAMWELFY" FT misc_feature complement(10308..10337) FT /note="PS00518 Zinc finger C3HC4 type signature" FT CDS join(complement(12003..12030),complement(11906..11965), FT complement(11754..11855),complement(11656..11711)) FT /db_xref="GOA:O13825" FT /db_xref="SWISS-PROT:O13825" FT /label=spac19a8.09 FT /note="SPAC19A8.09, len:81" FT /gene="SPAC19A8.09" FT /product="hypothetical protein" FT /protein_id="CAB11645.1" FT /translation="MFGFGNILYVTLLLLNAVAILSEDRFLGRIGWSQSAALGFGDRQD FT TIKSRILHLIRAIRTVMTFPLIAINTIVIVYNLVLG" FT misc_feature complement(11712..11728) FT /note="ctaattttaaattttag, splice branch and acceptor" FT misc_feature complement(11748..11753) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(11856..11872) FT /note="ctaattattgaaaatag, splice branch and acceptor" FT misc_feature complement(11900..11905) FT /note="gtatga, splice donor sequence" FT misc_feature complement(11966..11977) FT /note="ctaatttgttag, splice branch and acceptor" FT misc_feature complement(11997..12002) FT /note="gtaaga, splice donor sequence" FT CDS complement(12505..15654) FT /db_xref="GOA:O13824" FT /db_xref="SWISS-PROT:O13824" FT /label=SPAC19A8.08 FT /note="SPAC19A8.08, len:1049, SIMILARITY:Arabidopsis FT thaliana, O80955, t16b24.10 protein., (1029 aa), fasta FT scores: opt: 931, E():0, (25.5% identity in 1014 aa) also FT some similarity to Saccharomyces cerevisiae, NMD2_YEAST, FT nonsense-mediated mRNA decay protein 2, (1089aa), fasta FT scores: opt: 216, E(): 1.4e-05, (22.3% identity in 1152 FT aa)" FT /gene="SPAC19A8.08" FT /product="hypothetical protein" FT /protein_id="CAB11644.1" FT /translation="MSREEQIKKLNQYLDNRELAFRAKDGDKNIFHTESQLDSSLKKNT FT AFMKRCKSSLTSENYDSFIKEIKTLSLKKFIPEITAAIVEGMMKCKATKDILSSVKIVW FT ALNLRFSTAFTGPMLANLYCALYPNPGYSLCHESYFELKQNENEVSEKDRSSHLLKVRP FT LLRFLIEFWLNGVVGTPEDFVSYLPSTDSNDKKFRKPWFEEQNLKKPLVVLLFNDLMDT FT RFGFLLLPVLTSLVRTFSCELFTTEDFEDKETLELVNRLNPVVWRTYLRKSLNSYVDKL FT EVYCQKRKSLFEELNKQYQEQSIIRADPNNEKFQRLANFSKSIESEFSSYASLSEVLNR FT KASEDLLELNFMEKASSGTNSVFNASGERSESANVETAQVWDDREQYFFYEVFPNFNEG FT SIAEMKSSIYESSQEGIRSSSENNKKEDDLKDSTGDLNTTQVSSRVDNFLLKLPSMVSL FT ELTNEMALEFYDLNTKASRNRLIKALCTIPRTSSFLVPYYVRLARILSQLSSEFSTSLV FT DHARHSFKRMIHRKAKHEYDTRLLIVRYISELTKFQLMPFHMVFECYKLCINEFTPFDL FT EVLALLLESCGRFLLRYPETKLQMQSFLEAIQKKKLASALASQDQLVLENALHFVNPPK FT RGIIVSKKKSLKEEFLYDLIQIRLKDDNVFPTLLLLRKFDWKDDYQILYNTIMEVWNIK FT YNSLNALARLLSALYKFHPEFCIHVIDDTLESLFSAVNNSDHVEKQKRLAQARFISELC FT VIHMLDVRAITNFLFHLLPLEKFESFLTMKASTLTNINNDMFRLRLIVVVLQTCGPSII FT RSKTKKTMLTYLLAYQCYFLIQPEMPLDMLYEFEDVIGYVRPSMKVYMHYEEARNALTE FT RLQAISDDWEEDDTRPVFQGANDGDISSNEESVYLPEDISDESETDEESSGLEESDLLD FT SEDEDIDNEMQLSRELDEEFERLTNESLLTRMHEKNPGFDVPLPLRASSLGSPYVTRNE FT ESASESSHVMFTLLTKRGNKQRSQYLEIPSHSSLVRSTKNQQTEEIMERKRVKEMVLNF FT E" FT LTR complement(17946..18294) FT /note="solo tf2 LTR" FT CDS 18428..19297 FT /db_xref="SWISS-PROT:O13823" FT /label=SPAC19A8.07c FT /note="SPAC19A8.07c, len:289, SIMILARITY:Saccharomyces FT cerevisiae, YNH5_YEAST, hypothetical 33.5 kd protein in FT mks1-msk1 intergenic region., (290 aa), fasta scores: opt: FT 1043, E():0, (52.6% identity in 291 aa)" FT /product="hypothetical protein" FT /gene="SPAC19A8.07c" FT /protein_id="CAB11643.1" FT /translation="MLRRAVRERRQFIYKRNQELQEAKLNEKRRALRKALEGNKELNKD FT LQEDSQLQKDYKYDESRATQEETETNLDDEYHRLGEREPKVLVTTSREPSSRLAQFAKE FT VRLLIPNSYRLNRGNIVVGSLVEAARANDITDIVILHEHRGIPDGLVISHLPYGPTLSF FT SLHNVVLRHDIPNTGTMSEAYPHLIFENLTSKLGKRVKTALSALFPPDPKDTTPRVVTF FT ANTDDYISFRHHIYAKTGPKQIILSEAGPRFEMKLFEITLGTVDMVDADVEWKLKPYQR FT HKRDVLAE" FT CDS complement(19677..20870) FT /db_xref="SPTREMBL:O13822" FT /label=SPAC19A8.06 FT /note="SPAC19A8.06, len:397, SIMILARITY:Saccharomyces FT cerevisiae, YNS1_YEAST, hypothetical 46.5 kd protein in FT npr1-rps3 intergenic region., (407 aa), fasta scores: opt: FT 594, E():0, (37.0% identity in 389 aa)" FT /gene="SPAC19A8.06" FT /product="hypothetical protein" FT /protein_id="CAB11642.1" FT /translation="MSVVCSCLLPTPSTDFVNQRNMPIPIIAHIAQFKYEHLITHWAQY FT TKAAIAVSTIAAFKFWTSGRTTTWERKMNGMVVMVTGGSSGIGQVVVEKLASLGAQVVI FT LLRTEPDQFTVDYIMDLRKRTKNQLIYTEVCDLSSMLSVRKFATKWIDCTPIRRLDMIV FT LCSGVLLPPFMDRQTTEEGVELQWATNFLGPYQLLRILRPVIYGQPGHREVRIVAATCS FT SYILGNIDFNDLDLSNHPYPRKSPWKVVGNAKLALMTYLYDFQKKAEAHERPDKMPCNL FT HTIMANPGVVRTPGFRRVVSFGKVWGLFLYLLLWPFWWLLLKGTIHGAQSFFHAICSPE FT FASITQPVLVNECSIVEYSRKEITDPEFAEKLIKAADAQIDEVEKQYKKKKIKKSKK" FT CDS 21830..23662 FT /db_xref="GOA:O13821" FT /db_xref="SPTREMBL:O13821" FT /label=SPAC19A8.05c FT /note="SPAC19A8.05c, len:610, SIMILARITY:Saccharomyces FT cerevisiae, VP27_YEAST, vacuolar protein sorting-associated FT protein vps27., (622 aa), fasta scores: opt: 828, E():0, FT (35.3% identity in 501 aa)" FT /gene="SPAC19A8.05c" FT /product="putative vacuolar protein sorting-associated FT protein" FT /protein_id="CAB11641.1" FT /translation="MSRWWNSNSQFASDIEKATSETLPAGSEEISLYLEISDQIRSKSV FT DPKFAMRILKSRIDHSNPNVQIMALKLTDTCVKNGGSGFLLEIASREFMDNLVSILRSP FT AGIDEDVKMVILRYIQSWALAVPDTNSPLSYIIHVYQNLKDGDYEFPEPSQNITSKFLD FT TETPPDWTDSEVCLRCRTPFTFTNRKHHCRNCGGVFCNQCSSKTLSLPHLGINQPVRVC FT DSCYSLRTKPKGSKSRARNERKFHAKTRKTPSKPVTNNEDEDIKRAIELSLKEMPQSRE FT PPSYERPSEANVVISQDQHLTEDEDEELKRAIAISLEEAQKSSQKDDNVTAPNNMNISY FT PSVPAHTVSTDIRSSPFSGRPSDNPSTLISTADADNITLYATLVQKLKKLPPGSIFTEY FT QLQELHENMGVMRTRMMRSLGETMSKYNGLIQALQKLQTCMRLNDALIEQRLSSTYAHH FT YIDSSMDSNRSIEPEPDVISTVRNSSTIPQASSSSVPKIVVDSSPVTENPPSHSDVMGQ FT KDTISSYYSTDTDVSANVMGNRHDEVVFSDTASGEKNTKLNIDESTNYYNTDSIDKVGE FT PFDEISSGYDDLMNGNDKQGNDIPEVQEASLIEL" FT misc_feature 21848..22267 FT /note="Match to PF00790 VHS, VHS domain Score 228.06" FT misc_feature 22331..22522 FT /note="Match to PF01363 FYVE, FYVE zinc finger Score FT 136.70" FT CDS join(complement(25689..25815),complement(23858..25356)) FT /db_xref="GOA:O13820" FT /db_xref="SPTREMBL:O13820" FT /label=SPAC19A8.04 FT /note="SPAC19A8.04, len:541, SIMILARITY:Candida albicans, FT CAA21953, cytochrome p450., (517 aa), fasta scores: opt: FT 1706, E():0, (51.8% identity in 485 aa)" FT /gene="SPAC19A8.04" FT /product="putative cytochrome p450 (EC 1.14.-.-)" FT /protein_id="CAB11640.2" FT /translation="MNQTETLIPAARNVIRVLGYEIEYSKWTICFALLAVCIAYDQISY FT QMQKGHIPGPRFKIPFMGSFLDSMKPTFEKYNAKWQTGPLSCVSVFHKFVVIASERDLA FT RKILNSPSYVQPCVVDAGKKILKHTNWVFLDGRDHIEYRKGLNGLFTTRALASYLPAQE FT AVYNKYFKEFLAHSKDDYAQYMIPFRDINVATSCRTFCGYYISDDAIKHIADEYWKITA FT AMELVNFPIVLPFTKVWYGIQSRKVVMRYFMKAAAESRKNMEAGNAPACMMEEWIHEMI FT ETRKYKSENKEGAEKPSVLIREFSDEEISLTFLSFLFASQDATSSAMTWLFQLLADHPD FT VLQKVREEQLRIRKGDIDVPLSLDLMEKMTYTRAVVKECLRLRPPVLMVPYRVKKAFPI FT TPDYTVPKDAMVIPTLYGALHDSKVYPEPETFNPDRWAPNGLAEQSPKNWMVFGNGPHV FT CLGQRYAVNHLIACIGKASIMLDWKHKRTPDSDTQMIFATTFPQDMCYLKFSPFDASTV FT DWKNSKEAFSNEAVSAATVETESA" FT misc_feature complement(23987..25330) FT /note="Match to PF00067 p450, Cytochrome P450 Score 98.74" FT misc_feature complement(24101..24130) FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand si FT gnature" FT misc_feature complement(25357..25371) FT /note="ctaacatttttttag, splice branch and acceptor" FT misc_feature complement(25683..25688) FT /note="gtatgt, splice donor sequence" FT CDS join(complement(28434..28457),complement(27802..28377), FT complement(26677..27756)) FT /db_xref="GOA:O13819" FT /db_xref="SPTREMBL:O13819" FT /label=SPAC19A8.03 FT /note="SPAC19A8.03, len:559, SIMILARITY:Homo sapiens, FT CAB38778, dj710l4.2, (401 aa), fasta scores: opt: 751, FT E():0, (39.1% identity in 435 aa)" FT /gene="SPAC19A8.03" FT /product="putative myotubularin-like protein-tyrosine FT phosphatase" FT /protein_id="CAB11639.1" FT /translation="MENIKVAKVGNVKFVNKGNELNGTLHLTAYHSIFSISENGKEIWT FT AYSMINNVKLCSNEKSFCIRIQCRDFMFFCWRFQSTEDAMDVYDTLQELMSINSINMLY FT AFYYMPSGDEEKLPSSWKSFLLENEYRRMGVGDSTQADGAGGNWRITKINENYSECHSY FT PQALAVPASISDSVIYYGCKYRSKNRFPTLTYLHKNSFSITRASQPLVGIRQNRSAQDE FT KLVEAIFATSIIPGKENLIVDARPSTNAMANIAVGAGSENMDHYRFAKKIYLGIDNIHV FT MRDSLNKIVNALKNTDISAAPPLIELLNRSSWLKHLANILQGAVLIVKTVHFRHAHVLV FT HCSDGWDRTSQLCALPQLCLDPYYRTIEGFFALVEKDWLSFGHRFAERCCHLPGKRIFT FT IDSSYSEEPPQSSPSSTLQYTFSTVRSALSGFSIDHSEKMMSPVFHQFLDCVWQIMDQF FT PNCFEFNERFLRRLLYHLYSCQYGSFLYNSERERAQASVSTHTRCIWDYFLSRKDEFKN FT PNYVPYDDVIMPDPSSLRWWSASFAQPDENMNIPSPSESPSL" FT misc_feature complement(27301..27339) FT /note="PS00383 Tyrosine specific protein phosphatases activ FT e site" FT misc_feature complement(27757..27769) FT /note="ctaatttatttag, splice branch and acceptor" FT misc_feature complement(27796..27801) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(28378..28388) FT /note="ttaacaaatag, splice branch and acceptor" FT misc_feature complement(28428..28433) FT /note="gtaagc, splice donor sequence" FT CDS join(complement(29347..32648),complement(28909..29248)) FT /db_xref="GOA:O13818" FT /db_xref="SPTREMBL:O13818" FT /label=SPAC19A8.02 FT /note="SPAC19A8.02, len:1213, SIMILARITY:Saccharomyces FT cerevisiae, YHV5_YEAST, hypothetical 143.6 kd protein in FT spo16-rec104 intergenic region., (1228 aa), fasta scores: FT opt: 191, E():0.00012, (20.9% identity in 1288 aa), also FT some similarity to Saccharomyces cerevisiae, SIP3_YEAST, FT (1229aa), fasta scores: opt: 160, E(): 0.013, (21.0% FT identity in 1294 aa)" FT /gene="SPAC19A8.02" FT /product="hypothetical protein" FT /protein_id="CAB11638.1" FT /translation="MAAPANASSKKDHVIPVLLNECSIDSPSFRASMYYLGNQIKAFNE FT WSHDFLCCCNKFIESIMAIEPIVASMSLNAMPSNVASGFFDPDYATTALLHGQDLFRSS FT YMVQLQQAKNLRKFIVAPLDLFRDSKVKPLLQLNDRFKAEQAKYDAEVLRYSSLGHSKD FT LSQMRDEAKSLYEARKSYFTVALQYVVRVTSFRSSIDFIVIESICKFSIETFRLTDRLH FT ESNRHINDQLIRLLSYETKLKESYPSLKRIVSNVFDRIEKEILKRVQPPTNLDAYRFDP FT QQICQTNATKRQGWLLRNISSSKADNKAIWRKYWFFVDNGYVGYLINDANGGVFESEKI FT GVLLCKFSVLPSNHRKFCFQIKTKSVSYILQAETHMEMLEWGSVINNAREHCINSGISA FT NRILSPTLPSFSAKATSIINPQVNGRSNSTGKIGKNYRPRRTYSGRLLCGPNNYEVSTI FT MRSPTISTVPPPKYLSNSINGAKFLNPLAPWTLVNAPLITNLTHETITSLLDQEAFFHG FT NSPCALLANFWGSVNYGHVLERQNVYIEDLSNPSYKRLAREIHIEKLPSELKLRNAEFR FT GIFGESEASTVLFVCRVCSKREDQIRMPGRMYCTMKGIYIYYNINGLVLIEHFPISSIL FT NVKQFASTKCDYFYMNIQNIGTVRFRLYLDSSKALTDRLNVLLCNYIADKPNSSIQLLS FT CIKRLNDDVKRFERGGDDNALKSYGVQPSQEDLLIRRGRSSRALTNLINKNESNDSFME FT DLRDFKIAMLPKETVQVVRSHHLDDIVFDRVYNVSTKALFHIVFGDRSTVLSGAYNLHG FT VDDVEFLPWGKDPKTNLSRRYINYKVYNYDQEGQCQSYHYEDCQIMDVRNDYHLYIMTW FT LHHSWTLPYRDYFKIVTKTSISHLRREKSRLLISVGLEWIVKPFAISKVIEAECRKLAI FT KYIKTEVNFLEKATRRARNQPLIAIINQYGRVGDYNESMVYRRKIPFNCELKNLSIIDI FT IRNNWWLFLQGLAIDLLKLPWAVFHIFLRYLFSHSFLVIIFACSVILNLSLMFCFGAKY FT WDERQNNKFVGQVFDEFKNIETSARYVYMKDVDDLLVGLPTYLHPNVTYPSECLQSFAL FT KSSPQKSHWLRKRNYIAEKRKKILENLASLNYYEYIIHEDAVYQYIQQELLGCDKAREF FT DLYPPSMQRYCDSCTQDWRNRTLFFGKDTLATRLLTLETVENADYAA" FT misc_feature complement(29249..29263) FT /note="ctaatctttttacag, splice branch and acceptor" FT misc_feature complement(29341..29346) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(30186..30218) FT /note="PS00133 Zinc carboxypeptidases, zinc-binding region FT 2 signature" FT misc_feature complement(31485..31781) FT /note="Match to PF00169 PH, PH domain Score 48.39" FT CDS 34574..35858 FT /db_xref="SWISS-PROT:O13817" FT /label=SPAC19A8.01c FT /note="SPAC19A8.01c, len:427," FT /partial FT /product="hypothetical protein" FT /gene="SPAC19A8.01c" FT /gene="SPAC23H3.01" FT /protein_id="CAB11637.1" FT /translation="MTFRIPSSQESSNKSEKDTTVNSPNASSFSSFFKKSSQTYLSKRS FT EKLNEHNSKLKSSGSFTSNSQTDLSNSPSSKKKNIFYPIARAKHSFYFNHNWSSDLQQA FT NSPVASYSSQSVSNDSNFPKDVTSPISTDLSGSNPSLKSPSSINSAKLRASRSFFRFPK FT WSRKSWNPDVNSTTSSPSEVGSLDKAGGPLNQQNENLSAESDNTILQNGTRKSSVKMSD FT LGKRIASLPVVKRPPIQFSISSDYIKPVDKSDQTSNVPSPSSSVGSLRLYRSPSIPNDV FT EQPQPQSSRSRPRSSTIPTQRTLERLRENRSSIFSFRTLRRDDDECVAQTIENSALFSD FT IKPNPTKFLSSVPELTADDTAESYLSKLRETVPYSRMIPVLAEKDHVTLNKALHLCMSG FT MEFENRPLDFCLRLFLLKSHLPKETQQID" FT misc_feature 35840..35858 FT /note="nominal overlap with cosmid SPAC23H3, EM:Z99163 S. FT pombe chromosome 1" XX SQ Sequence 35858 BP; 11622 A; 6502 C; 6430 G; 11304 T; 0 other; gatccgaatg taattgagat attcgttaac gttcactgct aatagatcgt tgctgattgc 60 tcctctaaat ctaatgcaat aaaacacaac ttgaaatatc gtaaagagat gcaatttcac 120 tccaatttga tccttgcaag agcctaatta atttctgtcc taatttaatg aattaaacag 180 aatgcttatg gtttcataaa taatgtagtt tttatatggt tgatgtggtg gttttaattc 240 acatatcgct cttcacttaa ctaaccgaac aattatatta cgaactctaa cgtactacct 300 tgccttagaa acgacgcccc caatacatat tggtaaatcc tttagtaaag tgaatgaacg 360 atcgattgct tctaatgagc aagtctttgt ttttaagacc tattatttga aggatacttt 420 tgtcgaatgg gtacatctag ggtcatatgt aattcataga atatatagat aaatcataat 480 tttgtcctca actttactat taactatgtg gggaattgtg gagaaacact aatgttacat 540 ttactgtcta aactgtaagc gagaatacta cctatctgaa tattgtaata taaaaacata 600 gaaacattac taaattttta aaaatttgat ctgtaccact tgtttgattt tatacttttt 660 tttcaattta ttctacgggt aatgctgttt taggagtgcg aacttaagta attgtaattg 720 ggagttttac catagttcaa agatttgtga cactttttat tattcagtgc taaagacttg 780 agtggtctta ttaggcgaat atacagaaag aattttattt tctctccata aactgctaac 840 ttcaatctgg aagatttgct aatataccaa agattaaagc ttatgttaat agactatgtc 900 gcgactctaa aaagccaaaa ccatataaat tgaaaatact acgacatctt gctcgtgctg 960 ataaattgtt ttaaaacatt ttttgcactt gcattgtagt gtaaatagga catgattctc 1020 aaaatcatag actaaagaaa accgctttgt tgaatgttct tcttcagcat acacataatt 1080 ctcttaagcc tttgaaaaat tagcctaaga aattaaatcc acagaaaacc tttattaggt 1140 aaataagtac agtattatgt acaggttatt acatgactac aacgctattt aaggctagta 1200 aatagtagaa gcaaaattga aatgatattt atagataaaa agaaatacac atatgttttg 1260 gtataaaaaa gtttaatcgc atgcgatgct tgtatatcta tagatcgcaa ctccgcttaa 1320 gtttacggag ccttaatata aatcagaaaa tcgtgagtag aacattgctt aaaagcgaag 1380 gtcccatcca attttaggac ctaaaatagg aagttgttca gctacgcttt gaacatcctt 1440 gtcaccacga cctgaaatgg tgatcacaat atccttatct ttaggtaact ttttagcaag 1500 ctccattcca ccatacacag catgagaaga ttccaaagcg ggaatgatac cttcaagatg 1560 acatagagcg cggaatcctt ctaaacattg agcatcagtg acagcgataa actctgcgcg 1620 attggtatat ttaagttcag ataattcggg tcccacacct ggataatcca atccagcaga 1680 tatagagtga gtatcttgaa tttgtccatc ttcgcgttgc agaacatatg ttcgaactcc 1740 atgaaataca ccaacttttc ccatagtcaa tgtagcacta tgtttggggg tatctacacc 1800 atcaccacca gcttcacaac ccaacatcat tacactttta tcggctttga agggagaaaa 1860 cattccaatc gaattggatc caccaccaac acaagcaaca actgcatcag gaagtttttt 1920 acgcttctct tgcatttgcg ctttcgtttc ctcgccaatg acactttgga aagttttaac 1980 aatggtaggg aatggatgag ggccaattgc agatccaatt aaataatgag tggtgtctat 2040 ttgttcgacc cacgccttca aagcttcgtt aacagcatca cgaagggtct gtgtacctga 2100 agtaaccgga acgacttcag ctcccaaaag acggatgcga aaaacgttga gtgcttgacg 2160 acgacaatct tctgcaccca tgtagatagt acatttcata ccaaatttag cggcacagat 2220 agcagtagca actccatgct gaccagcacc agtttcagca atgatacggt tttttcctaa 2280 acgtttggca agaagaattt gcccaataca gttgttaatt ttgtgtgaac caccatgatt 2340 caagtcttca cgcttcaacc aaatatgggc accaccacaa tactcagtta aacgcttagc 2400 ataatcgagg gcacttggac gacccatata ctcataataa gaacgaaatt cttcccaaaa 2460 cttttcatca tgcaaagcct tataaaatac actttcaagt tcaactaagc actgggttaa 2520 tgcttctgga acatacatac caccaaacat gccatatttt tgaggaagat acatttcgtt 2580 gataggttcg accacagcag cagggggggc agtagcaaca gaaccaccgg attgaaactg 2640 tttaggtaca ggtgcggatg ggtcttcttt agtaagatat ttacaatatt cctcaaccac 2700 ggtagcagca gtgccaggct ctgccttcaa aatcaaatcg ataattttgc ttccaactac 2760 aacaccatct gacacgctgc caacttggtg gaaatgttca ctggtgttaa caccaaaacc 2820 aactgctaga ggggtatctc cagcaaattt acgaacacgc tgacagagct gaggcaaagc 2880 agtattgatt actccggtag cagatgatcc tgtactaccc atacgagaaa caacgtaaat 2940 aaaggagtca gccacagagg ccaagagctc catacgcctg tccgtagtag aaggagcaac 3000 aagaggaacg aaactaacac cttgcttttt acattcttct ctaaagccga cagcctcctc 3060 tggaggaagg tcaacgatga tgaaaccatt agcgccaacc tcctttgcct tttgaatagt 3120 tttggcatct ccataactga aaataggatt gtagtaaccc atcaaaatta tagggatagt 3180 tacacctgca tcacgagcga gctttacagt ttcaaatact ttttctaaag taatattatt 3240 cttcaaagca atttcgtttc ccttgcaaat tgtaggacca tcagcgacgg catcagaaaa 3300 aggaatacca agctcaatta ttcctgctcc tccattttgc aaaccttgca taattttgat 3360 agtttcatca acattaggaa aaccgcaagt gacaaatgtc actaaaacat ttttgttttc 3420 ttcttttgct ttgagaaacg tttttttaat ctgctctgtc atttttcatg agttttgcga 3480 tagtcaaaaa aatattggcg gtggaacaga gattggaggg accgacagaa tagatcgtta 3540 agatttcaaa cgaagatgac catattgata agtcaaataa ttttatagat aactaaatta 3600 agtttcaaaa cattataaaa tcgttaaggc ctgcaattgt ggtgcagatt gaaccaaatt 3660 tcgtaagttc atgggcaaat taccttcagg tggatggatg ttaaactaaa aagttaaatt 3720 tcgacttcac cattaacttc acttgaatgt aagctgttta ctactaatat aaaagtatat 3780 gcctagttga tactaaattt tgttatgaat gaacggaatc aacctgagac atcaatgtct 3840 agattaatca aatgtaagta aatgagaatt ggggttgctg actttcattg ttattagaaa 3900 tatatacagt ttttacagaa cggaagctga ttgcacagac aattcgcctg tcgaaaaata 3960 agagtattgg cgttacatag caatccatca aaaaagtttg tcatattttg ttgcattaaa 4020 tatcaccttt tggtacattt tttagatttc tcagaataat tttaaagatc ctgtaacctc 4080 attgattacg ctgacaggcc caggaccaat gcccaagact gtagcagaac cagatgcaat 4140 ctgggtgcga ccagcatcgt gtataaccct ggcacatagc cctagagaca ttgcttgggc 4200 ttgcagtaat tccaacgtct cttcggtttg agcttgaaga gtaattttag cctgtccagc 4260 attttcccat atacgtacca aatcggggtc caccgcagat gcgattttgt agcaggctaa 4320 ggctgcatgc gcacattgag ctgctatttt tcctttggtc atgcctaaat ccgtcctaac 4380 gaccaatacc attttagttt gtccttccgc caatgcaagc gcagccaaac tgctgtttcc 4440 tttcagcata tctaaaagtt cagtttcgga ctcgctgtct tcatcattgc taacagaaac 4500 aggactttct ttttctgggt tagatgcttt gttggcattt ttggaactat aacctcttga 4560 tgcatctgct acactgtatt tgcgtccgat cataaacccc actacagcgc cgacaagtac 4620 tgctgcagga aaggaggaga tcatgaaatt tacgaaaggt actttcataa ctactatgaa 4680 attataatgt caaaataatt atgtgtgcga aacttaagag ctaagaaaca taatatatac 4740 cggcaacatc attaaattga tgtagtgaag cgcaacatac tcctctcaaa actattaatt 4800 tgtttcacaa aattaataat gatgcattca gagaaattaa tattaaattt cattaaaaga 4860 acgaagaagg atatctcata tatgtgtttg aaaagtttga ctgaccagaa gccaactcat 4920 ggtacttatt taaatttagg cgtctccaat cttctatgcg cttctccatt ttaacatgat 4980 aactcgaaga aagaatgagt aatcaagagt atacaaaaaa ttatgtttag cgttaacatt 5040 gaagtgagac tttctaacat caattgtagc gacgacgctt aggggaacta tctcttcctc 5100 catagtctga agagtgagag gagcgagtag gaccacgacc aaatcttgac cctcctccag 5160 aagattttcg aaatcctcct cgatagccac cacgaaatcc agagtcgcca cgaaatcggg 5220 atccccgttc ccgtcgcggc ctttcttttg tataatgtcg cccgccaagt ccaccaccta 5280 acttacgcgg tagccatcct tttacagttc tacctctttc gacatcgacc actatccgcc 5340 ttccatttag catcaaacca gctgatgctt tgtaagcaac ttttaaatct cgttcccttt 5400 caaacacaac aaatgcatat cccattgatt ttcctgtaac tttattacga acaactcgta 5460 tgcgctcgat aggcccatat cgagtaaatt ctcgttcaat atcgctttcc ttggtatcat 5520 agcttaaccg agaaagaaac atagttttat atggatctcc aatgacatgg cgatcgtgat 5580 caggatccca taccttaatc atggaccgta atctttctcg ttgctgtttt tgtttctcgt 5640 ctctaagacg caaacgcttt tcttccaagc tttcagtcgg gtgatattgt tgatcgtgag 5700 actgcgcata tttcagatat tttgctatgc ctgaaacgcg aggtgttgaa cgtttctcag 5760 gaggcacatc cataggaggc agatacctca atgggggacg tggagcaaac aatgcaagta 5820 gaggagccgg taatttttca gccattctat atgaattgtt tttttttatt tagaagtgtg 5880 tgggtgcaat gctgtgtagg gtatatccca gtaaagcgat attgcctgta taataagtgc 5940 tatgtggggg cgtacagtac aattttttcg cttattatta aaatatgtaa gcaaattata 6000 tagtcatatt tatttgacat aaaagggaag caaatatgta tttaccctat gaataaacct 6060 agtacacgca tgggctgcat caaaaggaaa cctcataatt ttaaaggacg aaaagcctca 6120 ccagctaata aaagttaggg aaatccttat ttcaacgttg aattcatgca tgattaaaac 6180 gacaacaaca gaacattgag tagaccgtta ttctcaacaa aaagtgatag aaaaaaatga 6240 aaagagccac tagattaact cagtgttcaa cattaacatc taagtctcat ttaaagtcag 6300 tagtcttgat attcattaac aatttgaatg taaaacgaaa aataaacatt aaaggaataa 6360 ctttagaaga gaataccata tgtgtattac acagtcgttc attagtttct aatgcaatgc 6420 caattagaat aacaaattaa tgaagaccat tggagttaga agacacgaca gattgtaaat 6480 atgacagaaa atgatcatca gaccctttga aatcggattc ctgggtatct tccttttttt 6540 gatctgccaa aggcgaacgt tttaaaatct taacgaaacc aggactcata tcaacatggt 6600 ttttgttggt ttccgaattc tccttcttct ttctattttt caattttgat tgcgataatt 6660 cgtttcgttt aggaggaacc tcagactttt gttgcggaga tacttttagt aaatcaaact 6720 gattagcggc ttctagtggc tcatcatttc tgggaatacg aagtgtcttc tttaacaaat 6780 cagtgctttt gctgtagttt ttgacctcca actcctttac ctgactggaa gctttgcgtt 6840 cgttattctg tgatttattt tgcaaatcgt ttgcaggagt aggcaatcca gatttaagaa 6900 gtgtaagtaa acttaacgaa tcagatgtct ttttcggtgt ttcctctttt gtttcggttg 6960 cggatggatg taagagagct tgaagtaatt gtgcggagtg tacagaattg gcgttaggat 7020 tattacaact ttcaccatgc aaattatctg atatttcctc tccttgacta ttgtcagaaa 7080 atttctttgt ctctaatgaa ttaggcgtca aaaaaagatt cgctaattga acatttgcct 7140 ctttgcttaa cgtagaagat gagggtgtcg tatcctgctg agagagcata cttaataacc 7200 tttttgaatt tgagtctcct tccgaattat atgattgacc tgagttatcg gaatttcgag 7260 ctaaaaactg agtctgagat tgaaaaggag gaagagaaga aatttgttga gtctgatgac 7320 catttacata gggagaagaa gatccgtatg ctggttgcgg agttttgcct aaaccatagg 7380 aactaacgga agtcgaagtg ggaggataaa aaacttgatg ataaacagta cttggcgagg 7440 gcaattccat tggagaaggc atgtcgctag cggcaaataa atgctgaaca gaattttggt 7500 ctttaagtaa atttgaatac atactctgct gaaagtgatt attcaacaca ggtttattag 7560 ttaacatgtt gttttgagaa acaactcttg gaaaagaagc agatggattt tttggatcca 7620 atccaaggta agcaaaagga tcgaaactgt tattatcatg cgataaacga gaattgctgc 7680 tttgaatggg gggattaaga ggaaggttcg acacaggagg aagttgaatt ggagatttag 7740 gttcatttcc ttcatttaat aaatgcaaga ttttctgttt aatgtcaaaa gaagaatgtg 7800 attcaactgg tggctgagga aaagttgaag gttgcggagt agcaaggtct gaaggtgctg 7860 tcgaagattt caaaagagaa agcagttggg aagaagcatc agcatcaaca tcaacggaaa 7920 tgttcttttc tttggtagtg ttattggcaa tattcctctt cttaatccat ttcttcaatg 7980 gcgccaaaaa tgggattacc atgtaaaatt tgtttttcat ggtctgaggt ttattttttt 8040 tgaatgtagg aagatccata agattatgcc attcaatttt actaatttct tttcttgtac 8100 gagattcaaa tcttgtatcc aaagatattc caggaataat atacaatcga acgttttgtc 8160 cacgtatagt catatcaata aattcattag gatttatacg gctagaacag tcaaagcctg 8220 tttcttcata tacttcacga atagcacaat caacatcaga ttcatcttta tcaatttttc 8280 ccttaggaaa tccccagccg gatgatgctt tccatccttt gacaagtacg cattgctgca 8340 ttgacatatc aagcattata gctccgcgga caggaatacg agtcttatat cgtaaaaaat 8400 catcaaacgc ctcttcatgg accttactcc acttccacaa taaaggacag tgagcaaaaa 8460 gctttgcact aaaaacacgc aaacctagtg atggcaactg atcgttttgc gcacgtataa 8520 aatcttcata aaaccaatga gcttgttcga tttgaaaaca aagtcgttca acgctacttt 8580 gctcctctgc tggtaaattc aagataaatc tagctgataa atcatccagc acttgcgaaa 8640 acgtggcatt tgtgaacgac atatttcttt taatatatag tagtctattg tttgcattta 8700 aaattctaag tcactccaaa gcacgacaaa ttcgtcaact ttaatttttg tgcgtcttgg 8760 tatttaaagc catttatgcg tgtgcgtata acacagagtt agggacacgt aaaattacgt 8820 accaaccttc gttagtgata aactaaacca ttattgattt aggaatgtat cacactgcgc 8880 tatactattg ctcaatcctt gtttcattaa actgttagac tgtagttaaa atcacaattt 8940 gccttacctt taggtctttc gagaatttat ttatccacca aaaacttgtt taatattcta 9000 cagaactgat tgaaaatata aaaaagcgaa ttaatttttg ctaagtacat aaaatcatat 9060 gcgagttatt ttggttatag gtcgctctaa ttctggaaag ctagatttta ttaagggtaa 9120 atattagtgt tctatttgca attactaatt gaaaagcttt gacgggttct ttaccgaagg 9180 ggttagatga cgaggcattt aacaatgatc attctggctt gattcataag tataatatca 9240 gaaataaata ttttgaagct tcggttggta tttggattga agaatattct aatttagctg 9300 aaactttgga tgcttatagt tctgaagaag cgaaggaagt tattgatagc ttaggtgcca 9360 ttgtatatac ttttcgaagt tttgatgaag ctgagtggtc tctttttaaa aattttatag 9420 ataaactaca gctagagatt ccggtaattg ggttgcacat gtcagatgaa aaattactag 9480 aaccacctga tgtgtttacc ccagaatata tttctatcag cgaggaagga gtgaatgaat 9540 tcaatggtaa agtcaaccaa tcttctattt attaacaagt ctctttagag aaagtaggac 9600 tggaccgtgt tcgagaaatt ctcgattgct gcgaatggaa cttgtcacaa gttgataaaa 9660 gtttctcgga agaaaaggat gatgccggag atttctatct cccggaacga ttcaaaggaa 9720 gtccagacat gcaatcgacg gatctggata atttgatgaa agaaatgaac caaattagag 9780 gttggtaact ccttgagtcg actaaactaa caacgaaatt tagatgctga cctggaaaaa 9840 aatgagaaaa aggccaaggc tttaaatctt ttagaaaaat tgttaggcga tgaattcgag 9900 gaaaatgatt atgaatcgct gtagaaacaa ggcctttgtt cgtatccgga gaatacatgt 9960 tgtcgctgga gcacaaattg atgtataata actatttgag tttgcaagaa aggttcaatt 10020 aagttttatc aaagtatttt ttactaaaat ctaaatctgc tgtattgaaa gaggacctat 10080 tagcaactta aaaaaaattc gtaagtaaag ctcagtcaca aattgtgata attttggtcg 10140 tatttcatta ttatagacat tataaatcca acacaatgga ctacattttc aatgtacaag 10200 gttcgtcaat aaaataattc ccacatggca tttttcgtat ttaaataacg gccacagtca 10260 ttcactagac attttgactg agatcgttta ctggttttca aaacttttgc acaagagcca 10320 caatagacgt gaccacactt tgttgcccat aatgcagatt tctctttgct tttggatgtt 10380 cctaatggtt cctgacatct tggacaaacc atcaatgtat cattgttaaa gcttctagta 10440 aatccagatt ttggagggcc tggaggcttg taagactgtt ttatattttc taaagaagaa 10500 gtaaaatcat catatgattc ttcaaaatgg ttagagaaat attcgtcgtc tgaaccgtta 10560 gtccattctg gatgtatagc gtcaaatctc attcggttca caatcaactg gaaaagagaa 10620 ggggataagg aattaacaga actaaactca ggaaatgtcc tggcaatcat tcccatcaaa 10680 tctcgacgtg aagaagaacg acgagtggac acctgaggac ctaagtaaat catgtcttcc 10740 aaatacgata aatgatttga aggaaagtta cgagaccgtt cattccttct ccggttcata 10800 cgccttcttc gaggacttag aacaggagat gatggaaagc tgtcatcagg aatagcatcc 10860 aaatcaatga tatttgttga agaaatagaa gtttcgactg gtggagaagg tgatctcgtc 10920 aaatcaatta cactgctttc atctattcca ttgcttccat taaattgcat tgatgtgtga 10980 aaaaagatac acaattgttt cctgtcaagt aattgacaac gggcaaaaaa ttaagtcgat 11040 ttatttgtat atattttggc cttgcatata ttaacgaaac ggtattattt aatataaagc 11100 tctaatgtat tgctgtatat caaaataccg cagaccaaca gttcggtgca tttttaaggc 11160 aatgtccagt atgctttatt atttataaac taatggctag taaagaaacg taaattagaa 11220 gtcgcatttc tttgtttaca cattatcttt ataaaaagga aatgacctta tgtgataatt 11280 tactgagaag atcaaacgcc aaagaagata tggcgaatag aggaatttta cgagcttaat 11340 ttagcaagaa gaaccaaaaa aatatgcctc tagtagacga tatggatttt ttattaaagc 11400 acagaaaatg aatttaaaat actagacgat atttgatagt acaattgttg aagaattagg 11460 attgtattta ttaaatccgc tagattctga agttaaactt tcacaaatga gtaattggaa 11520 catcagcgct tgaatatcaa gttcctgtct tgaatttttt tgagtataaa tatgataaat 11580 caaataatgg ataacactgc ttttagacca gcatcaaaag cgagcgacat taacaaagat 11640 tcgtaaagcc tttaatcatc ccaagacgag gttataaaca ataacaatcg tgtttatggc 11700 aataagaggg actaaaattt aaaattagaa attataaagt ttttaatact tacaagtcat 11760 gacagttctt atagctcgaa ttaaatgcaa aattcggctt ttgatagtat cttgtcgatc 11820 accaaatccc agggcagcac tttgggacca tccaactatt ttcaataatt agaacaacat 11880 atttggttaa aattgtagtt catacttctt cctaaaaatc tatcctctga aagaatagca 11940 accgcgttta aaagcaataa agtgactaac aaattagaaa gctgcgttca aaaacatctt 12000 accatataat atatttccaa acccaaacat aatgctcgat actttttaat acaattgaag 12060 ttcaatattt ttttttaaag gttttggtag tgatttaatg ccagaataca gcagcatatt 12120 acgtatcgtt atgcaagtta tggttttcac ctttgactga aagcaaaaag acttctataa 12180 attagaaatt tacatgttag ataataaaaa atctcctgaa aataataatg tatcaatttc 12240 ttagcttcga acatattatt agtgaactgt tcagtgtttt tcaattggta ttaataaagt 12300 attgtaccta attagcttgc atattttaga atgtaaataa ttaaagaagg ctaccatagt 12360 aaattgcaag ctttgatttg gtaatgaaaa agctaaatat tatacaaaag gttcgtctat 12420 tctagttgta aacgaagcag gtaatttacc agcaatggct tagaatttcg gtatttagag 12480 gacgaagata aacaagagct tctcttattc gaagttcaaa accatttctt taacacgttt 12540 ccgttccatt atttcttcag tttgctgatt cttggtagac ctgaccaacg aagaatgcga 12600 gggaatctct aaatattgag aacgctgttt atttcccctt ttggtcaata aagtaaacat 12660 cacgtgcgac gattcgctag ctgattcctc atttcttgtc acatatggag agcctaggct 12720 agaagctcta agaggaagtg gaacatcaaa tcccggattt ttctcatgca tacgagtcag 12780 taagctttca ttagttaggc gctcaaactc ttcatcaagc tctctactta attgcatttc 12840 gttatcaata tcttcgtctt cactatccaa cagatcagac tcttccaatc ccgatgattc 12900 ctcgtctgtt tcagattcat ctgatatatc ttccggcaga taaacacttt cttcattcga 12960 gctaatatca ccatcattag caccctggaa tactggacgt gtatcatctt cttcccaatc 13020 atcagaaatg gcctgaagcc tttccgttag agcattcctg gcttcctcat aatgcatgta 13080 tactttcatg ctaggtcgca catatcctat cacgtcttca aattcataaa gcatatctaa 13140 aggcatttct ggttgaatga gaaaataaca ctgataagct aatagatatg taagcatcgt 13200 ctttttcgtt tttgaacgga tgattgatgg tccacaagtc tgcaaaacta caacaataag 13260 tcttaatcga aacatgtcat tgttaatatt ggttaatgtt gacgctttca tggttaaaaa 13320 agattcaaat ttctctaatg gtagtaaatg gaacaaaaaa tttgtaattg cacgcacgtc 13380 gagcatatgg atgacacaaa gttcagatat aaatcgagct tgtgccaatc ttttttgctt 13440 ctccacatga tcggaattat taacggctga aaacaaactt tccagtgtat cgtcaatcac 13500 atgaatacag aattctggat ggaacttata aagcgcacta agcagacgag caagagcatt 13560 taaagaatta tattttatat tccaaacctc cataattgta ttgtacagaa tttgataatc 13620 gtctttccaa tcaaacttcc taagcagtaa aagggtcgga aagacattgt catcttttaa 13680 acgaatttga attaaatcgt acaagaattc ctctttcaat gatttttttt ttgaaactat 13740 gataccacgc tttggcggat tgacgaagtg taaagcattt tctagtacaa gctgatcttg 13800 agaggcaagc gcagaagcca attttttttt ctgaatggct tctaaaaacg attgcatttg 13860 caacttggtt tccggataac gaagaagaaa tctcccacaa ctttctaaaa gtaatgctaa 13920 aacttccaag tcaaatggtg taaactcatt tatacacaat ttatagcatt caaaaaccat 13980 gtggaaaggc atcaactgaa atttagtaag ttcagaaata taacgaacaa taagcaatct 14040 agtatcgtat tcgtgcttag cttttcgatg aatcatcctt ttgaacgaat gtcttgcatg 14100 atctaccaat gaagtggaaa actctgatga aagttgagaa agaatacgtg ctaatcgaac 14160 ataataagga acaaggaaag acgatgtcct agggatagtg cacaaagcct ttataagtcg 14220 attcctagat gcctttgtat ttaagtcgta aaactccaag gccatttcat tcgtgagttc 14280 taaggaaacc atggagggta attttagcaa gaagttatca actcttgagc ttacttgcgt 14340 tgtatttaga tcgcccgttg agtccttaag atcatcttct tttttattgt tttcagatga 14400 agaacgaata ccttcctgac tggattcgta aatgctactt ttcatttcag ctatagaacc 14460 ttcattaaaa tttgggaaca cctcgtaaaa aaaatattgc tctctatcat cccaaacttg 14520 agccgtttca acattggcag actcactcct ttcgcctgat gcattaaaca cgctattagt 14580 tccagaggaa gccttttcca taaagttgag ttccaagaga tcttcggaag cttttctatt 14640 caatacttct gaaagagaag cataagaaga aaattcagac tcgatcgatt ttgaaaagtt 14700 agcaaggcgc tggaattttt cattgtttgg atctgccctt ataatgcttt gctcttgata 14760 ttgtttgttt aattcttcaa aaagagattt tcgcttttgg cagtagacct ctaatttgtc 14820 tacgtaggaa ttcaacgact ttcttaaata agtcctccac acaaccggat taaggcgatt 14880 aactagttct aaagtttctt tatcttcaaa atcctctgta gtgaaaagtt cgcaagaaaa 14940 agtcctcacc aaagatgtca aaaccggtaa caagagaaac ccaaatcttg tgtccataag 15000 gtcattgaat agcagaacca ccaagggttt ttttaaattt tgctcttcaa accatggctt 15060 acgaaacttt ttatcattcg aatcagtaga aggtaaataa gagacgaaat cctcaggagt 15120 gccaacaaca ccatttaacc aaaactcaat caaaaaccta aggagcggtc taactttgag 15180 taaatgagag gaacggtcct tttcggaaac ttcgttttca ttttgcttta gttcaaagta 15240 tgattcgtga cacaatgagt atcctgggtt tgggtataaa gcacagtata agttggccag 15300 catgggtcca gtaaaagccg tggaaaaacg cagattaaga gcccaaacaa ttttgactga 15360 cgacagtatg tctttagtag ctttacattt catcattcct tctacgatgg cggcggtaat 15420 ttcaggaatg aactttttca aagacagggt ttttatttcc tttataaagg aatcgtaatt 15480 ttcagaagtt aatgaggact tacatctttt cataaatgct gtatttttct ttagagaaga 15540 atccagctgg ctctcagtat gaaatatatt tttgtcacca tctttggctc ggaaggcaag 15600 ctctctatta tccaaatatt gattaagttt ttttatttgt tcttctcttg acataattta 15660 acgaaattgc attgaaaagc acttcaattc tcatatcttg tttagaacac tagtcgacga 15720 tagttggcgt aaagtgagta gataaatttg acacatgtcc tcttccacaa cgaaataata 15780 ttgtaaagta actatggcaa gtatcttaaa ttatactggt tttttttttt aaaaaagaat 15840 aaacagtatt ggattatatt ttagttgcat aaatgctata ttgttgctgc agtttcatat 15900 attagaggaa taaatcaatt ggggatgatt agaagcaata ggaggtttgt gcattggtac 15960 aatttaaaca taatttgtta ggcatgaaga ataaaacagt taatacaggt agatgtatgc 16020 atcatcttga taaggacctt ttatgattga cgaaaatata tctacggttt ccacttttac 16080 gcttactgtt gatgtgtaac aatcttaaat aaaaaggaaa aaaaggtaac agtagcaatt 16140 tattgaagct attaagtgtg ctaacagaaa ttcaatacaa ttgttgatac tcagaaaggg 16200 taattaagca atactcagaa aaccatgtat tgccttcgaa taaataaaac acttttataa 16260 ataaatatca tattcaacaa aaaattgctc agatcgttaa aacattagtc taggatacga 16320 gaaatgtttc tctccttgta ggtagcagcc tttccagtat gatcgttcaa tatttcataa 16380 cgagtctcct ctccgctatc gtttttaatc acctgctgga taactcctgt tgaggtgctg 16440 gtaccgctag ggccaccaat cttaaaccat ttgttaatac ttaatcacag tcgaaaaact 16500 tcaagacaca attcggtaca caaaatacag tgtacttaac tgacatgcct gaatcaaaaa 16560 ttcctactta caggatggta ttcgactttg tttcctttag aatatttggt cattttttaa 16620 acgatatgaa tatttatgat tttagtatgc aaacctccaa attatatagt ttttttatta 16680 tgaaagtggc aactaaacct cttaaacaat tgcacataat gttgtcgtga gtaagacgta 16740 aaccatctag acgtaatcaa tgcctttgat aatttttgtg tgaaatctga tacatgcaac 16800 cctgcagtac aacgtagcac gtttcatcac ttcgtgaaga cacatggata aatcgttcat 16860 catccaacac ttccatttga gaagaagcgg cgattgacat aactatagtg aacgtaataa 16920 attgtgattg aaaaccaagt tagtcttgtt tttttacgtg gcatcgaagt tatatctata 16980 gaaatgtagt atagaaaaaa aatgtgtgag attgaaagat agatagatat taattcattc 17040 caacttttaa aacaatggta gtttagcgta acgatttttc gtcatattta ctcatcaacg 17100 agaataattt ttcccattga aagttatctg gatgagaccg gagttcgctc atgaggttgc 17160 aaatacgagg ttagattaaa tcgactttct cattactacc agcataagaa aagtgatcct 17220 aagcattttt taaaacatta gtgaactttt cgaatcaatg tacagtgttc ctacttcgca 17280 ctttaaaaga tttagttggg taggaaaaac aatgtcaatc ctaacagtaa ttaaacggat 17340 gtagaatttg gaaaatcgac aaacattgtc atagtcaact tttttatatg aatgtgtttc 17400 caattcccaa tattctgggt tcatacaagg ctaatccttc atcaataagc ttcaattacc 17460 tatccttgtt tattatcgag cattttcaga acctggtaaa agcttctaaa aattcaaaaa 17520 atcggtcact cttttttttg gttcgtgaat tatatttttg ttttgcttcc cctaaaacgt 17580 ttgatgtgaa agttaaataa tacggatagt aaattttcta aaatatctct tcttctgcct 17640 tcagctactt ggctgtttgg atggataagt tataaaccaa ttaaattttt agaaaagaat 17700 atttaactat agtagtatac ttagtcggat aaaccttttt ctactgtagt ttaaccaaca 17760 atgttttaca aagattttca gtgctataat gcgattaggt tgtaagtgta attttattta 17820 aaagtctaaa cttatgatca tattaaaata cgcacatttc gtatatatac gtgctcagtt 17880 gattagtgaa gacgaacata taaatgatga acgctataga acaaaaagta ttaaactgag 17940 acaagtgttt gctacacagt ttggtatccg atttaaggat acgtagaact gcggtgagtt 18000 ttccttgtgg tctattatat tacaatacac aggttgtata agtagcaact gagtataggt 18060 attgtattaa ctgggttata atgttaccta tcactaatat agctcataac tgaactgagg 18120 aacgaggttc agcagtagct ctatttatag tattcagata atattgatct taatagatta 18180 tcattaagat caatctccat atcgtatcat acatggtacg atatataatt agaacatgtg 18240 acatatagtg atacgcaacg tagtgtatca tagcgtagtg tagtattgct gacattagtt 18300 cgcgacctat ccccatgcaa aaaatatttt cggcattagt gttaagaacg aggtgcatac 18360 aactttcgca ttgcaaacag ctagttgcat actgcaagtg taattttttt taatttaata 18420 atttaagatg cttcgtcgtg ctgttaggga aagaagacag ttcatttata agagaaatca 18480 agaacttcaa gaagcaaaac tcaatgaaaa acgacgtgca ttaagaaaag cattggaagg 18540 taacaaagaa ttgaacaaag atttgcagga agacagtcaa cttcaaaagg attataaata 18600 tgatgaaagc agagcaactc aagaagagac agaaaccaac cttgacgatg agtaccaccg 18660 tctgggtgag agggagccaa aagttttagt taccaccagt cgagagccct catctcgtct 18720 agcgcaattt gcaaaagaag tacgtctctt gattcccaac tcatatcgac tcaatcgtgg 18780 taatatcgtt gtcggaagct tggtagaagc cgctcgtgcc aatgatatta ccgatatagt 18840 cattttgcac gaacacagag gtatccctga tggtcttgta atttctcatc ttccttatgg 18900 tcctaccttg tcattttctt tacataacgt ggttcttcgt catgatatcc ctaatactgg 18960 taccatgtca gaagcgtatc cacatcttat ttttgaaaat ttgacttcaa agttgggaaa 19020 gcgcgttaaa acagctcttt ctgctttatt tcctccagac cctaaagata ctacaccacg 19080 tgtggttaca tttgctaaca ctgatgatta tatcagtttc cgtcaccaca tttacgccaa 19140 aacaggccca aagcagatta ttctatctga ggctggtcct cgctttgaga tgaaactatt 19200 tgaaattacc ctcggcaccg ttgatatggt agacgctgat gtggaatgga aattgaagcc 19260 ttaccagcgt cacaaacgtg atgttttagc tgaatgagcg taggtatgat gggtatggtc 19320 aaacggttat tttaggttca tttgggatac aggtaaataa ttacaattct tttatgtata 19380 ggcaaggcca ttagagtgaa tggtatcttt gataaataag gaggcaaaac tttctagtat 19440 tagtggttaa tggttatact attcaaaaca ttagtgaagt agaacatata tcagtagcga 19500 ttgtacttgg gttccttttt tatattttaa ttagtttact tgagcaatgt ttatgtacag 19560 cttaaagttt aagcactgta tttgtctttt taaaaatacc aaccttttaa cttcggacct 19620 acgttattat ggtgaatatt ccaaccaaat gacattccat atttttcgct aaacttctat 19680 ttttttgatt tcttgatttt cttcttcttg tattgctttt caacttcatc aatttgggca 19740 tcggcagctt ttattagttt ttcagcaaat tccggatcgg taatttcttt gcgtgaatat 19800 tcaactatcg aacattcatt tacaaggacg ggttgagtaa tcgaagcaaa ttcgggactg 19860 caaatagcat gaaaaaatga ttgagcacca tgaatagtac ctttcagaag aagccaccaa 19920 aacggccaaa gtaacaaata aagaaataat ccccaaacct ttccaaagga tacaactctt 19980 cgaaatcctg gagttcgaac gacacctgga tttgccatga tggtatgtaa attacacggc 20040 attttgtcag gtcgttcatg agcttcagct tttttctgaa aatcataaag ataagtcatc 20100 aaggcaagtt tggcatttcc cactaccttc cagggacttt ttcgaggata tggatgatta 20160 gataaatcaa gatcgttgaa atctatatta cctaaaatat atgatgaaca ggtagctgca 20220 acaattcgta cttccctgtg cccgggctga ccatatataa ctgggcggag aatcctaagt 20280 agctggtatg gacctaagaa atttgtagcc cattgcaact caacaccttc ctcggtagtt 20340 tgcctatcca taaatggagg cagtaaaact ccactgcaca aaactatcat atccagccta 20400 cgaataggag tgcaatcaat ccactttgta gcgaacttcc taacagataa catagagctc 20460 aagtcacaga cttcagtata aattagttgg ttttttgtac gctttctaag gtccattatg 20520 taatctacag taaattgatc tggctctgta cgaagtagaa taacaacttg agctcccaga 20580 gaagctaatt tctctacgac aacttgtcct attccagaac ttcccccagt gaccatgact 20640 accattccgt tcattttacg ctcccaagtt gttgttcgtc cagaagtcca gaatttaaag 20700 gccgcaattg ttgaaaccgc aatcgcagcc tttgtatatt gagcccaatg tgtaattaga 20760 tgctcatact taaattgtgc tatgtgagca ataattggaa taggcatatt tcgttgattt 20820 acaaaatctg ttgatggagt tggcaaaagg cagctacata ccactgacat tgaggtatac 20880 taaactcgtc ttcatattta attcttaaca atcaaaaatt taaaactttt ttttatacaa 20940 ttgttttaac tttagatgga tttaattgta caattattta atcgcttgac tgctagtgca 21000 tattactaat agcaactagc tccataaatt tgacaaagat aggattgaat tgtttttgta 21060 tatatacata atgtaattta tggaccgtaa aacagattgc ttacaaattg gaaagtaaaa 21120 tagactgttt atatgatata tatgtgaaat ttgaagatat actaaatact tgttttaaca 21180 taggaaaatt aagtatgtgt atactacaac atttgacata ttatttttta taatatttca 21240 agaaacactg tgatagtata taattcgcat agcaaatata aattattacg gtctgtctta 21300 ttagcaccta ccagaagtac agcactcaat ggtgaggtat cgttttcctt ctttgcttat 21360 ttatggtacc ttcaaaaagg ctgaaactac attgcacgct ttagcttgat ctacctaatg 21420 agtctataaa catcatcgat atttacgaca attagtgttc tctcaatact tgctttacta 21480 tatttgccgc tctgcactat caaccgttat accgagatgt gctaagctgc ccgcactatt 21540 acttagcaag tttgagccac gaacaatctg ttattgctgt cgagaaccaa actctttctc 21600 aaattgaatt ttattggaaa ggaggattta caatacatta ttttgccata atttcaaaca 21660 atcagaagaa ttgtgccaaa gttgttatac ttcacctgct gcttttgttt attaggaatt 21720 tttgaaggcc attggttatt tgtttggtga caatttagct tacaaataat aaaaagattt 21780 cttttgtttc ttaatttcgg tttttctttt cttctctatt ttcataacga tgtctcggtg 21840 gtggaattcc aattctcagt ttgcttccga catagaaaag gctacatcgg aaacgcttcc 21900 tgctggctct gaagaaattt cattatattt agaaatttct gatcaaatac gtagtaagtc 21960 tgttgatccg aaatttgcta tgcgtattct taaatcccga attgatcatt cgaatccgaa 22020 tgttcaaata atggcattga agttgacaga tacctgcgtt aaaaatgggg gttccggttt 22080 tttattggaa atagcttcta gagagtttat ggataatttg gtatctattc tacgatctcc 22140 tgcaggaata gacgaagacg ttaaaatggt cattttacga tacattcagt cttgggcttt 22200 ggcagttcca gataccaatt ctccacttag ttatattatt catgtttatc aaaatttaaa 22260 agacggtgat tatgagttcc ctgagccttc tcagaacatt actagcaaat ttttagatac 22320 tgaaacaccg cccgattgga cagatagtga agtttgtctt cgttgtcgta caccttttac 22380 attcactaat cgtaaacacc attgtagaaa ttgcggtggc gtgttttgca atcaatgttc 22440 ttcaaaaaca ctttctcttc ctcaccttgg aattaaccag cctgttaggg tatgcgacag 22500 ttgttattca ttacgtacga aacccaaagg ttccaaatca agagcgcgaa atgaaaggaa 22560 attccatgcg aagactagaa agacaccctc taaacccgta actaataatg aagacgaaga 22620 tatcaaaaga gctattgagc tttccctcaa agaaatgcct caatcacgag aacctccatc 22680 ttatgaaaga ccttcagagg ccaatgtagt tattagtcaa gaccaacatc ttacagaaga 22740 cgaagatgaa gagcttaaac gtgctattgc tatcagcctt gaggaagcac agaagtcatc 22800 tcaaaaggat gacaatgtta cggcacctaa caatatgaat atttcttacc ctagtgttcc 22860 agctcacacc gtttcaactg atattcgatc atctcctttc tctggtaggc cgagtgataa 22920 tccttctact ttaatttcta ctgcggatgc tgataacatc actttatatg ctactttggt 22980 gcaaaagtta aaaaagctac cacctgggtc tatttttacg gaatatcagc tacaggaact 23040 ccacgaaaat atgggtgtta tgcgaactcg tatgatgcga tcgcttggtg aaacaatgag 23100 taaatataac gggctaattc aagctttgca aaagctccaa acttgtatgc gattgaatga 23160 tgctctaata gaacaaagac tttcatccac gtatgcacat cattatattg attctagcat 23220 ggattcaaac cgatcaattg aacctgagcc ggatgtaatt agcactgtga ggaatagttc 23280 aaccattccc caggcttcgt cttcttctgt cccgaaaatc gttgtcgatt cgtctccggt 23340 aacagaaaat ccccctagtc attctgatgt gatgggtcag aaagatacta tctccagtta 23400 ttactcgacg gatacagacg tttctgcgaa tgtaatggga aatcgacacg atgaagttgt 23460 attttctgac accgcatctg gtgaaaagaa tacaaaatta aatatcgatg aaagtaccaa 23520 ctattataat actgattcaa tcgataaagt tggagagcct tttgacgaaa tttcctctgg 23580 ttatgatgat ttaatgaatg gcaatgataa gcaaggtaat gatattcctg aagttcaaga 23640 agcatcttta atcgagcttt aggttttaaa catcttataa tacatattaa atacttagat 23700 caatttatcg acaatgcatg tctgtttacg atccttttaa tatttttttg tttttcaaaa 23760 ttgatcaatt gtaacctaaa attcagaatg gtgaatacat acgtaaacta aactaataaa 23820 cgactataga ctccgaacct gggtagttat ttgtaaatca agcgctctca gtctccacag 23880 ttgcggcaga gactgcttca tttgaaaaag cctccttgga gtttttccag tcaacagttg 23940 aagcatcaaa aggtgaaaat ttgaggtaac acatatcttg aggaaatgtc gtagcgaaaa 24000 tcatttgagt atcagagtca ggggttcttt tatgtttcca atcaagcatg atactggcct 24060 ttccaatgca agcaattaaa tgattaacgg cataacgctg gcccaaacat acatgaggac 24120 cattaccaaa aaccatccaa ttcttaggac tttgctcggc aagaccattt ggtgcccagc 24180 ggtcaggatt aaatgtttct ggctctggat aaaccttaga atcgtgaagt gcaccataga 24240 gggtaggaat aaccatggca tccttgggta ctgtgtagtc aggagtaata gggaaagctt 24300 tcttaacacg ataaggaacc atcaatacag gaggacgaag acgtaaacat tccttaacaa 24360 cggcacgggt ataagtcatc ttttccatca agtccaagct gagtgggaca tcaatgtctc 24420 ctttgcgaat acgaagctgt tcttcacgaa ccttctgcaa aacatcagga tgatcagcca 24480 aaagttgaaa gagccaagtc atagcactag aagtagcgtc ttgggaagca aataaaaatg 24540 acaaaaacgt aagtgaaatt tcctcatcag aaaactcgcg aataaggaca ctaggcttct 24600 cagccccctc tttattttca gatttgtatt tacgagtttc gatcatttca tgaatccatt 24660 cttccatcat gcaagcaggg gcattaccag cctccatgtt cttacgggat tcagcagcag 24720 ccttcataaa gtagcgcata acgactttgc gtgattgaat accgtaccaa actttggtaa 24780 acggcaatac gatagggaag ttaaccaact ccatagcagc agtaatcttc caatattcgt 24840 cagcaatgtg cttaatagca tcgtcggaga tatagtaacc gcaaaatgtg cgacaagagg 24900 tagcaacatt tatgtcacgg aatggaatca tatattgagc atagtcatct ttactatgag 24960 cgaggaattc tttgaaatat ttgttataaa cagcttcttg ggctggtaaa taagacgcaa 25020 gagcacgggt agtgaataaa ccattgagtc ctttacggta ctcaatgtga tcgcgaccat 25080 caagaaaaac ccaattcgtg tgttttagaa ttttctttcc agcatcaaca acgcagggtt 25140 gaacataact tggagaattt aaaatcttac gggccaaatc gcgttcggaa gcgataacaa 25200 caaatttgtg gaaaacagaa acacaagaaa ggggtccggt ttgccattta gcattgtatt 25260 tctcaaaagt tggtttcata ctatccaaga aagatcccat gaaagggatc ttaaatctag 25320 gtccagggat atgccccttt tgcatctgat acgagactaa aaaaatgtta gaatcacacg 25380 gtacatatca atagactaaa taaacattga gaataaagaa ttagcaactc ataaatcaca 25440 attaaaatcc atggtaaata tgagatcgta gtaaatttat cattaaaacg aatgatttga 25500 tcactaggct ccattgataa agttggcaca gagtgacatt gtcaccagtt cccgaatagc 25560 agattcgttc gcatcagcaa agcgaaagta gataaattaa ttacttaaat cgagagaaaa 25620 tgatgctttt catcgtggta tttatgcagc agttgataca aaaaaataat tctcaatctt 25680 taacatactt tgatcataag caatgcagac agccaaaagg gcgaagcaaa ttgtccattt 25740 cgaatattca atttcgtatc ccagcacccg aataacgttt cgggctgcag gaatcaaagt 25800 ctcagtttga ttcatctcca tcgttttaaa ggaaggagca cgatgaatga atcaacaaat 25860 ccaactcgtt gggtattggt gaaggaaaag tccttgtcgg gctatcggtc ttatatagaa 25920 aattaccgac acgcaattat acgctccgaa atgagataga taaatctggt acgatgtgaa 25980 tcttacaata aagtaaaaaa aaaagaaaag aaaaatttaa agttatgaaa actaatacta 26040 taatttcaaa agctttctta ctgcagtaat tagaaaggct tactaacact cactattata 26100 ttgaaaaaac tcgttactgg gcagtcattt aagatcagct gttaaactac caatcatgag 26160 atgtgcaatc atacatacta tatataagca tcgcttagca tatctacacc aaactttgtt 26220 aagtgattgc atgagaatgc agtgaatggt ccgttatacg agtagagtag aagaacattg 26280 gaagaattga taaaataaaa gtatcatagg aacgggattc gtagtccaag cgataatcgt 26340 ataaaagggg ataaaaaaat tttagcatgg atcaccaaaa taaatggaag atttgggacg 26400 taaactttca aaatatgtat cagtaaatta aacgactctg tcgtcctctt catgcgttca 26460 tagtctctcg caaaagtcca tgtagataga ttatcggagt caacatgcga tgatgaaaag 26520 ttgaattagg caaaagagag gctaaaaaga gagaaagaaa gagatgcaat caatctaaat 26580 tgcgctaaaa tgagcataaa aaggaattaa taaagaactt ccaatgaaga caaaaatgga 26640 aggaaaatgt ccaatgaaga ttttcaagta aatgtttcat aaagacggag attcggaggg 26700 tgatgggata ttcatgtttt catcaggttg agcaaaagaa gctgaccacc atctcagcga 26760 tgaaggatca ggcattataa catcatcata aggtacatag ttaggattct tgaattcatc 26820 cttccgagaa aggaaatagt cccagataca acgagtatga gtgctgacgg atgcttgagc 26880 tcgttcccgt tcagagttgt ataggaacga accgtattgg caagagtaaa gatggtaaag 26940 tagacggcgt aaaaatctct cgttaaactc gaaacaatta ggaaattgat ccataatttg 27000 ccagacgcaa tctaaaaact gatgaaagac cggagacatc attttttcgg aatggtcaat 27060 tgagaagcca cttaaagcag agcgtactgt tgaaaaagtg tattgtaaag tcgaacttgg 27120 tgaagattgg ggtggttctt ctgagtatga gctgtcgatt gtaaaaatac gtttaccagg 27180 taaatgacaa catctttctg caaacctatg cccgaaggaa agccaatcct tttcgacgag 27240 agcaaaaaat ccctcaattg ttctatagta aggatccaaa cacaattgag gtagagcaca 27300 taactgggaa gttctgtccc atccatctga gcaatgtaca agtacatggg catgcctaaa 27360 atgaactgtt ttaacaataa gaaccgctcc ttgtaaaatg ttagccaagt gcttaagcca 27420 acttgatctg tttaagagtt ctatcaatgg aggtgccgca ctaatatctg tatttttaag 27480 agcattcaca attttattta aagaatccct catgacgtgt atgttatcaa ttccaagata 27540 tatcttcttt gcaaaacggt agtgatccat gttttcgctt ccagcgccta cggcaatgtt 27600 agccatcgca ttagtagaag gcctcgcatc aactataaga ttttcttttc caggaatgat 27660 tgatgttgcg aatatagctt caacaagttt ttcatcctgt gcacttcgat tttgacgaat 27720 acccacaagg ggttgagagg cccgcgtaat tgaaaactaa ataaattagt attaaagcct 27780 ctcaaagtta gtaaaactta cagaattttt atggagatac gtaagggtag gaaatcgatt 27840 tttagatcta tatttgcatc cataatatat aacactgtca gaaatgctag cgggaacggc 27900 tagagcttgc ggataagaat ggcactcaga gtaattttcg ttaattttag ttatcctcca 27960 atttccgcca gcaccatcag cttgggtgga atcacctact cccatgcgcc tatattcatt 28020 ttcaagtaga aatgatttcc aagaagatgg cagtttctct tcatctccgg agggcatata 28080 gtaaaatgcg tatagcatat ttattgaatt aatagacatc aattcctgta aagtgtcgta 28140 tacgtccatc gcatcctccg tgctttgaaa cctccaacaa aagaacataa agtctcggca 28200 ttgtatacgt atacaaaatg atttttcgtt agagcaaagc tttacattat ttatcatgga 28260 atatgccgtc caaatttcct tcccattttc cgagattgaa aaaatagaat gatacgctgt 28320 caaatgcaat gttccgttca attcgtttcc tttgttcaca aacttcacat ttccgaccta 28380 tttgttaata ttttgataaa attaagtttt agatctaatc gcattatgct tacttttgca 28440 actttgatgt tttccatcac acggaaactt ctttttataa gcaattgaat aaaatgaagc 28500 aaccctcgta ctatcaagta ctgtgacaaa atatgagtac aaagaattaa atatgtgttt 28560 agcgcagaat gtaattgcgt tctacttaga tagatgaagg ttttaaacta tttacggtgg 28620 tgctgtcgat taatgctgcc aagtgcatgg ctgtaatcat tgcggttatc aaggctacaa 28680 cttgacatat cattaccttg tttattaaac aatagaaagg acgattctga aagatgtaga 28740 ggagttacac ttatctttgg tatatatatg tttaataaat tcaactttat taatttgtgt 28800 atctgacaaa aaaaaacgag tgcttgatca aataactcat aaaaccctaa atataaaaaa 28860 gataataaaa taacaataaa aataattaag ttacagtttc attaacaatt atgcagcgta 28920 gtctgcgttt tccacagtct cgagtgtcaa taatcttgta gctagagtgt ctttgccgaa 28980 aaacaaagtg cggttcctcc aatcttgcgt gcaagaatcg caataccttt gcatcgaggg 29040 tgggtataaa tcaaattccc ttgctttgtc acatcccaac agctcttgtt gaatgtattg 29100 atatacggca tcctcgtgaa ttatatattc gtaatagttt agagacgcca aattttccaa 29160 tatttttttt cttttttctg caatataatt ccgttttcgt aaccagtgac ttttttgagg 29220 agaacttttt aaagcaaatg attgtaaact gtaaaaagat tagaataata ataataacaa 29280 aaaaaagata atataatgta catgtaatca acatttataa ttacatggta ctactaacaa 29340 acttaccatt cacttggata agtgacgttg gggtgcaaat aagtaggaag tccgactaat 29400 aaatcatcaa cgtccttcat ataaacataa cgagcagaag tttcaatatt tttaaactca 29460 tcgaaaactt gcccgacaaa tttgttattc tgtcgctcat cccagtactt agctccaaaa 29520 caaaacatga gagaaaggtt caagataacc gaacaagcaa aaataataac caaaaatgag 29580 tgagaaaata aatatcttag gaaaatgtgg aagacagccc acggcagctt tagtagatca 29640 attgccaatc cttgaagaaa aagccaccaa ttattgcgaa taatatcgat aattgacagg 29700 tttttcaatt cacagttaaa aggtattttt cttcgataaa ccatcgattc attgtagtcg 29760 cctactcttc catattgatt tattatcgca ataagcggct gatttcttgc tcttctagtt 29820 gccttttcca aaaagttgac ttccgttttt atatacttga tagccagttt tctacattca 29880 gcctcaataa cctttgatat agcaaaaggt ttaacgatcc attcaaggcc tacagatatg 29940 agcaatctag acttctccct tctaaggtga gatatagaag tttttgtcac gattttaaag 30000 taatctctat aaggcaaagt ccaagagtga tgaagccatg tcataatgta taaatgataa 30060 tcattgcgga cgtccattat ttggcaatcc tcatagtggt aagattgaca ttgaccttct 30120 tggtcgtaat tataaacctt ataattgatg tatcgacgac tcaaattggt ttttggatct 30180 tttccccatg gtaaaaattc gacatcatct actccatgaa gattgtaagc accagacaac 30240 acggtgcttc tatcaccaaa aacaatatga aacaatgcct tagtagaaac attgtacact 30300 cgatcaaata caatatcgtc cagatgatga gaacgaacaa cttggactgt ctctttcgga 30360 agcatagcaa tcttgaagtc cctgaggtct tccataaatg aatcattact ctcattctta 30420 ttgatcaaat tagttagcgc tctactactc cttcctcttc gaataaggag atcttcttga 30480 gatggctgta ccccataaga cttgagagca ttatcgtcac cacccctttc aaagcgtttt 30540 acatcatcat tcaatctttt gatacatgac aacagttgta ttgaactgtt tggtttatcg 30600 gcaatgtaat tgcacagtaa cacattaagt cggtcagtta gagctttcga agaatcgaga 30660 tagagacgga accttacagt cccaatgttc tggatattca tgtaaaaata atcacattta 30720 gtactagcaa attgttttac gtttaaaatg ctagaaatgg ggaaatgctc aatgaggacc 30780 aatccattga tgttgtaata tatgtaaatc cctttcatag tgcaatacat tcgaccaggc 30840 atacgtattt gatcctctct tttactacaa acacggcata caaataaaac ggtagatgct 30900 tccgattcac caaatatacc tctaaattca gcattcctca acttaagctc agaaggaagt 30960 ttttcaatgt gaatttctct agctaaacgt ttataagaag gatttgatag atcttcaatg 31020 tacacgttct gacgctctaa aacatggccg taattgactg aaccccaaaa atttgccagt 31080 aaggcgcaag gagaattacc atgaaaaaag gcttcctggt ccaaaaggct ggttatcgtt 31140 tcgtgagtca aatttgttat cagtggtgca ttgactaggg tccatggagc aagcggatta 31200 aggaatttag cgccatttat ggaatttgaa agatactttg gaggaggaac agttgaaatt 31260 gtgggagatc gcattatagt tgaaacttca taattgtttg gaccacataa caatcgtccc 31320 gaataagtac gacgaggacg ataatttttt cctattttcc ccgtagagtt tgagcgccca 31380 ttgacttgtg gatttataat tgatgtagct ttagcagaaa acgatggtaa ggtaggagac 31440 aagattcggt tagcagatat cccggaattg atacagtgtt ctcgagcgtt atttattacg 31500 ctgccccatt caagcatttc catgtgagtt tcggcttgca gaatgtagct cacggacttc 31560 gtttttattt gaaaacaaaa tttccgatga ttgcttggta aaacagaaaa cttacacaga 31620 aggactccga ttttttcgct ctcaaaaaca ccaccattgg catcattaat aagatatccg 31680 acatagccat tgtcgacaaa aaaccagtat tttctccaaa ttgctttgtt atctgccttg 31740 ctagaactga tatttcttag taaccaccct tgacgtttag ttgcgtttgt ttgacatatt 31800 tgctggggat cgaaacgata tgcgtctaaa ttagttggtg gctgtactct cttaagaatt 31860 tccttctcaa ttctatcaaa aacgttagat actattcttt ttagtgaagg ataagattcc 31920 ttaagtttag tttcgtaaga gagtaagcga attagttgat catttatatg cctattggac 31980 tcgtgcagac gatcagtcaa acgaaacgtt tcaattgaaa acttgcaaat gctttcaata 32040 actatgaaat caatggatga gcgaaaggag gtaactcgaa ctacgtattg tagagcaact 32100 gtaaaataac ttttacgagc ttcgtataaa gattttgctt catcccgcat ttgcgataaa 32160 tcttttgaat gtccaagaga agaatacctt aagacttccg catcatactt ggcttgctcg 32220 gctttaaagc gatcatttaa ttgaagcaaa ggcttaactt ttgaatctcg aaatagatct 32280 aatggagcaa caataaattt ccgtaaattt ttagcttgtt gaagttgcac catatatgac 32340 gaccgaaata agtcttgacc gtgaagcaaa gcggttgttg cataatcagg atcaaaaaat 32400 cctgaagcaa cattagaagg catagcattc aacgacatac tggcgacaat gggctctatc 32460 gccattattg actcgataaa cttgttgcag caacataaga aatcatgaga ccattcgtta 32520 aacgctttga tttgattccc tagataatac atgctcgccc taaaagacgg agaatcaatg 32580 ctacattcgt tcagtaagac tggaataaca tgatcctttt ttgaagacgc atttgcagga 32640 gcggccatga tttttcattt ccttctatta gtttccaaaa acttcaattc atataagaaa 32700 gcattaagaa cgatatgtcc actcgtctaa aggatgattt ttaaaccggt atatgcgctt 32760 tcggctgtcg gatgcggcat gtttgtagcg gcgtacttga tgtttttgac ttaagagtga 32820 cgctgcattt tttaaccaag atgaagcaat tcgttatatt agaataacga tatttaagta 32880 cttctattat aaggtaaaca aatacgaaat aactgagtgt tagaaattta atcacaagga 32940 aaatgtttca gctagctaag gaatttttac ttaaaatata taagtgaaat gattccatcc 33000 ttatacatat cataaatata aatacattta ctattagaaa aataaaagtg cttttaattt 33060 ttcgttttct tcttttttaa gtaaaattta ctaagaatga gttagcctta ttacaaaaat 33120 tgtggcacta atttgtgagc atagtatctt aatttatact tgatgtttgc acttaatctt 33180 ttttaagtca ttataaaaca atatacaaat tgagcacgat caataactgt aatggtcagg 33240 tttggttgta cttcaattgg tatgtaaaca aaatatttgg taaagtggtt aaataaattt 33300 tatgaacagt taggaattat gtatatagta aaacaaaagc atctctaaaa ttataaaaaa 33360 tacctagatt tttctgttgt gggtaaatta cttgttactt tttttattgc cacatctggt 33420 tgctatttgc tttcaaaatt aatttttaaa aaaaaaatta ttataatgag taaagggtgc 33480 aacctagaaa catgttcagc tgagcttgtt aaaaatattt gttatgttta taattttgaa 33540 gtagtgtatc ttaagcactt gcgatagcga actaaatttt tctaaatcat tgacattaga 33600 aataaaaaaa taaactacat tatggtgcca tttgccccat tagattatca ggaacatcgt 33660 gctagccatt tgctatctac gtttctatca gaccatgtcg gatttggtca tacgaggaag 33720 ggtgtggcag aataccttgc ggtgggcggg tttgtatgca ttgggcgata aagacacggg 33780 catgttgtgg acggagcaaa taacactact gtaaccaaca aaactagtat ttacttttca 33840 attctttttt ctggagcacc aaaacttgta ctcattatta aaattctagg gaaattaatt 33900 agttgaattg gttagcaatt gacgattcat taaatttcct gctatcaacc caaggacatg 33960 acttttgctc attaattttg tgttcgtatt tccattgagg gtttcaaatt actagagttc 34020 attttacttt cgttgctttg cttattcggt ttgctctgcg ctgcctaaat cagatcacac 34080 ttggtttttg tgcttttttt tttaaaaaat ttcgattcat ttgaaccgtc tcacagaagt 34140 ttcactttta catcttcgtt tcagtttctc gttctttgtt cataaccatt tttcatcttc 34200 cataccttcc agttcattac ttttcattca tttcatttca ttccatgctg catgcattat 34260 attaatcact aattgttttt cccttgttcg ttcgcttcgg tagtttctca attgattttt 34320 cttttgatta ttcgggaaaa aatatctgtt cattaaaggt aatacgttgg ttgctttctc 34380 cttattacag tcagttttat cctcgtatag tcgacaaatc tatctactgt ctccaattgt 34440 tataaattta gatcctgact taagtttaca ttacatttct ttttgaatct tcctttcatt 34500 ttcgaggtct ctctttactt caatcttttt taagtctttc tttttcttca acttacatgc 34560 gccgaggcgc gaaatgacct tcagaattcc ttccagccag gagtcttcaa ataaatccga 34620 aaaggatacc actgtaaatt ctcctaacgc ttctagtttc tcctctttct ttaaaaagtc 34680 tagtcagaca tatctgtcca aacgttcaga aaaactaaat gagcataaca gtaaactaaa 34740 gtcaagcgga tctttcacaa gtaattcaca gaccgacttg agtaattcgc cctcttctaa 34800 gaaaaaaaat attttttatc cgatcgcaag agccaagcac tcgttttact tcaaccacaa 34860 ctggtcttcg gatttgcagc aagcaaattc tcctgttgca tcgtattcaa gtcaaagcgt 34920 ttcaaacgat tccaattttc caaaagatgt cacgtctcct atttcgacag acctaagcgg 34980 ttccaatcct tctttgaaat caccatctag tatcaactcg gcgaaacttc gtgcttctcg 35040 atcatttttt cgatttccga agtggtctag gaagtcctgg aatcccgatg ttaactcaac 35100 tactagttct ccttctgaag ttggttctct cgataaagct ggtggccctc taaaccagca 35160 aaatgagaat ttgtcagcgg aatctgataa tacgatttta cagaatggta ctcggaaaag 35220 tagtgtcaaa atgtccgacc tggggaaacg cattgcttct ttacctgtag taaaaagacc 35280 tcctatccag ttttccatat cttctgatta cattaagcca gttgataaaa gcgatcagac 35340 ttctaacgtt ccatcacctt cttcttctgt gggttccctc cggttgtatc gttcgccttc 35400 tattcctaat gatgttgaac aaccacagcc acaaagctct cggtcacggc ctcgtagttc 35460 tacgattcct acccaaagga ctttagaaag attgagagaa aaccgttcta gtatttttag 35520 ttttcgaact ttgcgccggg atgatgacga atgcgtagct cagactattg aaaattcggc 35580 tttattttct gatattaagc ctaatccgac caagtttctt tcttctgttc cggagctcac 35640 agcagatgat actgcggaga gttatctctc aaagcttaga gagacagttc cttatagtcg 35700 tatgatccct gttctagcag aaaaggatca tgtaacattg aacaaagctc tgcacctttg 35760 tatgtcggga atggagtttg aaaatcggcc gttggatttt tgcttgcggt tatttttact 35820 taaatctcac cttcctaagg aaactcaaca gattgatc 35858 //