ID SPAC186 standard; DNA; FUN; 30176 BP. XX AC AL157811; XX SV AL157811.1 XX DT 22-FEB-2000 (Rel. 62, Created) DT 22-FEB-2000 (Rel. 62, Last updated, Version 1) XX DE S.pombe chromosome I cosmid c186. XX KW 2-hydroxyacid dehydrogenase; KW D-isomer specific 2-hydroxyacid dehydrogenases domain; gene free region; KW l-asparaginase precursor; l-lactate dehydrogenase; KW mitochondrail transit peptide; pyruvate decarboxylase; subtelomeric region; KW Tf1-type LTR; Tf2-type LTR; Uncharacterized protein family UPF0016 domain. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-30176 RA Wood V., Rajandream M.A., Barrell B.G., Seeger K., Harris D.; RT ; RL Submitted (22-FEB-2000) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; P87015; P87015. DR GOA; Q9P7P6; Q9P7P6. DR GOA; Q9P7P7; Q9P7P7. DR GOA; Q9P7P8; Q9P7P8. DR GOA; Q9P7P9; Q9P7P9. DR GOA; Q9P7Q0; Q9P7Q0. DR GOA; Q9P7Q1; Q9P7Q1. DR REMTREMBL; CAB75868; CAB75868. DR SPTREMBL; P87015; P87015. DR SPTREMBL; Q9P7P6; Q9P7P6. DR SPTREMBL; Q9P7P8; Q9P7P8. DR SPTREMBL; Q9P7P9; Q9P7P9. DR SPTREMBL; Q9P7Q0; Q9P7Q0. DR SPTREMBL; Q9P7Q1; Q9P7Q1. DR SPTREMBL; Q9P7Q2; Q9P7Q2. DR SWISS-PROT; Q9P7P7; LDH_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c186 is overlapped at the 5' end by cosmid c869, CC EMBL entry SPAC869, accession number AL132779. XX FH Key Location/Qualifiers FH FT source 1..30176 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c186" FT /map="IR" FT misc_feature 1..100 FT /note="nominal overlap with SPAC869 S. pombe chromosome 1" FT misc_feature 1..2929 FT /note="gene free region" FT CDS 2929..3909 FT /db_xref="SPTREMBL:Q9P7Q2" FT /label=SPAC186.01 FT /note="SPAC186.01, len:326, SIMILARITY:Schizosaccharomyces FT pombe., CAB69629, hypothetical serine/threonin repeat FT protein., (416 aa), fasta scores: opt: 334, E():2.6e-13, FT (33.3% identity in 261 aa)" FT /gene="SPAC186.01" FT /product="hypothetical serine/threonine rich protein" FT /protein_id="CAB75865.1" FT /translation="MNVVKYIIFSFALAPLLLVNANTYNFTQIQKRSVNQAVLESSQDT FT NSVGGEASSTACPLFTTIYTNGITPGTTTIYPTSISTSGVSSNNIDETSVSSESIITST FT ITTTITSGSQLYTTTITGQNTPVDTVEVVIPTAGTFTTTLTSGSSYPVATTTVRTASGT FT QSGEVEVITPSCGCSPENSFHLKIDNDKISPSYVYMDPNAPVRTNGAGREGNMFASTNG FT DNEGLNLFYYDSTIQRVLTCDCQRPSYTVYIEDPIIGNGFSSAWNLIKNSDGIFTPVES FT RNNEPLHFHVDNNGRVWMTSQEYDTEVSSTDERNFRANDVTLQLY" FT CDS complement(5199..6197) FT /db_xref="GOA:Q9P7Q1" FT /db_xref="SPTREMBL:Q9P7Q1" FT /label=SPAC186.02c FT /note="SPAC186.02c, len:332, SIMILARITY:Zymomonas mobilis., FT DDH_ZYMMO, 2-hydroxyacid dehydrogenase homolog, (331 aa), FT fasta scores: opt: 743, E():0, (47.6% identity in 319 aa)" FT /gene="SPAC186.02c" FT /product="2-hydroxyacid dehydrogenase homolog" FT /protein_id="CAB75866.1" FT /translation="MRVVLFSSQSYDRGPFEEANKTFNHEIIYHNFSLNKDTVSLAGKA FT QVVCVFVNDQVDADTLKALAENGVKLVALRCGGYNNVNLKAASEYKITVVHVPSYSPFA FT VSEFTVGLLLSLNRKIHRAYVRVREDDFNIVGLLGCDIHGKTVGVIGTGKIGSNVAKCF FT KMGFGCDVLAYDINPDKKLENYGVQFVEQNEVLKKADFLCLHCPLTPSTTHIVNSDSLA FT LMKKGVTIVNTSRGGLIDTKALVDAIDSGQVGGCAIDVYEGERNLFYKDLSNEVIKDST FT FQRLVNFPNVLVTSHQAFFTTEALCSIAHTTLKSASDFYTNSLDESVIANK" FT misc_feature complement(5310..5966) FT /note="Match to PF00389 2-Hacid_DH, D-isomer specific FT 2-hydroxyacid dehydrogenases Score 325.65" FT misc_feature 6198..10434 FT /note="gene free region" FT CDS 10435..11517 FT /db_xref="GOA:P87015" FT /db_xref="SPTREMBL:P87015" FT /label=SPAC186.03 FT /note="SPAC186.03, len:360, SIMILARITY:Schizosaccharomyces FT malidevorans., CAB69634, l-asparaginase precursor., (356 FT aa), fasta scores: opt: 1636, E():0, (70.2% identity in 359 FT aa)" FT /gene="SPAC186.03" FT /product="l-asparaginase precursor" FT /protein_id="CAB75867.1" FT /translation="MWRSIISFLFFSVALCQPFLFQKRSSNISDFISFNASLPNVTIFA FT MGGTIAGYASSSTETVDYAAGSVGIATLVDAVPAIKNFSNIRGVQVTNVGSEELTPANV FT LNLTQLILAEVAKPDVHGIVVTHGTDSLEETAMFLDMTVNTTKPIVVVGAMRPSTAISA FT DGPMNLLNAVVVAASNRSIGRGTMILLNDRIGSAFYTTKTNGNMLDTFKSYEAGFLGMI FT LDQRPHFFYSPATPTGKVHFDVSNTTELPAVEILYGYQGLNPNLAKAAVDLGAKGLVLA FT GMGAASWTDPGNEVIDGLISNQSIPVVYSHRTMDGFSDYYYNGIPSYFQNPQKARYMLM FT LSINAGYSIQNITDIFSLEY" FT misc_feature 10579..11475 FT /note="Match to PF00710 Asparaginase, Asparaginase Score FT 335.65" FT misc_feature complement(13275..13334) FT /note="Duplicated region in c977 S. pombe chromosome 1: sub FT telomeric region" FT CDS complement(13811..14338) FT /db_xref="REMTREMBL:CAB75868" FT /label=SPAC186.04c FT /note="SPAC186.04c, len:175, SIMILARITY:Schizosaccharomyces FT pombe., CAB69639, putative transmembrane channel protein., FT (598 aa), fasta scores: opt: 609, E():4e-32, (64.4% FT identity in 149 aa)" FT /gene="SPAC186.04c" FT /product="possible pseudogene, similar to N terminal of FT transmembrane channel" FT /protein_id="CAB75868.1" FT /translation="MNTSSRIQLPSSNDAHVYDGRSNEPKASKRSYVNLTRQMRPKDAL FT KMNISSPNLKDLSKFADPDAQQWLEGYLAGKLEDNSKTPRSNFVDPLYEELNARRKPNK FT PVWSLSGPLPHVLGNSVVEKLEARSRASSVSNSRLNSRTNSSVSLKGMDGSSSWKNKIK FT NAVSNVTDQSKR" FT misc_feature complement(13838..14256) FT /note="Duplicated region in c977 S. pombe chromosome 1: sub FT telomeric region" FT CDS complement(15587..16375) FT /db_xref="GOA:Q9P7Q0" FT /db_xref="SPTREMBL:Q9P7Q0" FT /label=SPAC186.05c FT /note="SPAC186.05c, len:262, SIMILARITY:Schizosaccharomyces FT pombe, YD68_SCHPO, hypothetical 31.3 kd protein c17g8.08c FT in chromosome i., (287 aa), fasta scores: opt: 777, E():0, FT (50.8% identity in 240 aa)" FT /gene="SPAC186.05c" FT /product="hypothetical protein with PFUPF0016" FT /protein_id="CAB75869.1" FT /translation="MINVESPLNLETTLGSLQFSHGSVQNIGMSISMIIGCELGDKSFI FT VTALLAYQYGRASVFFGSYLALFFMTSFAVLVGRAAPFLFPKSITHILGGTLFLIFGVK FT MLKESKEVRESQQSLENEFDKVEKIIVNEEDMKKTLELGLPASNRSSSTLKDKFFKVFS FT MSCFKNLFSKKFSRAFIKAFALIFVSELGDRSQIATIVMSAKEKVLDVFIGVNIGHMLC FT TMVAVIVGRYISNKIEMYKVLFFGGIVFMIFGILYIFQGF" FT misc_feature complement(15590..16291) FT /note="Match to PF01169 UPF0016, Uncharacterized protein FT family UPF0016 Score 278.33" FT LTR complement(16780..17089) FT /note="719 (-1) 44 349 Tf2-type LTR" FT CDS 17656..18210 FT /db_xref="GOA:Q9P7P9" FT /db_xref="SPTREMBL:Q9P7P9" FT /label=SPAC186.06 FT /note="SPAC186.06, len:184, SIMILARITY:Saccharomyces FT cerevisiae, YHI9_YEAST, hypothetical 32.6 kd protein in FT dap2-slt2 intergenic region.hypothetical 32.6 kd protein in FT dap2-slt2 intergenic region., (294 aa), fasta scores: opt: FT 219, E():1.8e-07, (26.5% identity in 189 aa)" FT /gene="SPAC186.06" FT /product="hypothetical protein" FT /protein_id="CAB75870.1" FT /translation="MSIKLGYLFKLPSYKTSSISPEVIVDLEKFLNLCEGSCSQCNTPF FT CVDVGPRNAIIQLPNGADVLNLNPNFQAIFECCSKNSLTGVQIFGMYNDGTYELRSFCP FT VHGVNEDPANGSGAGSVGVFFALNNPSIISSDFAHLLFNQGKILGRNALIRVAIKLSAN FT GLYDIHVGGGSKICISGTAEI" FT LTR complement(18480..18715) FT /note="degraded LTR" FT CDS complement(20852..21850) FT /db_xref="GOA:Q9P7P8" FT /db_xref="SPTREMBL:Q9P7P8" FT /label=SPAC186.07c FT /note="SPAC186.07c, len:332, SIMILARITY:Synechocystis sp., FT P74586, 2-hydroxyaciddehydrogenase., (333 aa), fasta FT scores: opt: 1132, E():0, (51.4% identity in 327 aa)" FT /gene="SPAC186.07c" FT /product="2-hydroxyacid dehydrogenase" FT /protein_id="CAB75871.1" FT /translation="MRIAFFSAQPYEKEPFEKVNENYKHEIDYHESILNKKTAVLAEKA FT PVVCVFVNDKVDADTLKVLAKNGTKLIALRCAGFNNVDLKAAADNGITVVRVPAYSPYA FT VAEYTIGLLLSLNRKIHRAYVRVREDDFNLNGLLGHDLHGKTIGLLGTGRIGGLVAKCL FT KLGFGCEVLAHDIKPNKELEKFGIQFVEQQEVLAKADFLCLHCPLTPDTEHLVDEKLLA FT SMKKGVKIINTSRGGLVDTKALVKAIESGQVGGCAMDVYEGERRLFYRDLSNEVIKDTT FT FQQLANFPNVLVTSHQAFFTAEALSAIAHTTLKNVSDFASQNNDPSVIVKN" FT misc_feature complement(20963..21619) FT /note="Match to PF00389 2-Hacid_DH, D-isomer specific FT 2-hydroxyacid dehydrogenases Score 346.23" FT misc_feature 22716..22859 FT /note="region duplicated in c16A3; c5G8; c569; possible FT telomere associated fragment" FT CDS join(complement(25193..25249),complement(24121..25056)) FT /db_xref="GOA:Q9P7P7" FT /db_xref="SWISS-PROT:Q9P7P7" FT /label=SPAC186.08c FT /note="SPAC186.08c, len:330, predicted to contain a FT mitochondrail transit peptide 1-24aa, SIMILARITY:Bacillus FT megaterium., LDH_BACME, l-lactate dehydrogenase, (318 aa), FT fasta scores: opt: 960, E():0, (47.9% identity in 305 aa)" FT /gene="SPAC186.08c" FT /product="putative l-lactate dehydrogenase" FT /protein_id="CAB75872.1" FT /translation="MTAGSKVFSNDSVRSSSFKSIKIVIVGAGNVGSTTAFTLLLSGLA FT AEIVIIDLNKKKAEGEAMDLNHAAPLSHETRVYLGDYKDCKDATAVVITAGKNQKPGET FT RMDLLKANISIFKEILREVTKYTKDAILLVATNPVDVLTYATLKLTGFPAERVIGSGTI FT IDTARFQYLIGKLYGLDPQSVNADIIGEHGDSELAVWSHASIAGLSLADFCEESETKYD FT EQALNECFKETKNAAYDIIQRKGSTEYGVAAGLVRILAAIIRDENALLTVSGLDSYSNI FT GDVCFSMPRKLNKDGAHRIINAKLSKDEDAKLVESVKSIKHAIESIGLN" FT misc_feature complement(24139..25050) FT /note="Match to PF00056 ldh, lactate/malate dehydrogenase FT Score 439.48" FT misc_feature complement(25057..25073) FT /note="ctaacttaatattctag, splice branch and acceptor" FT misc_feature complement(25187..25192) FT /note="gtaagt, splice donor sequence" FT CDS 28048..29766 FT /db_xref="GOA:Q9P7P6" FT /db_xref="SPTREMBL:Q9P7P6" FT /label=SPAC186.09 FT /note="SPAC186.09, len:572, SIMILARITY:Neurospora crassa., FT DCPY_NEUCR, pyruvate decarboxylase, (570 aa), fasta scores: FT opt: 2310, E():0, (58.5% identity in 561 aa)" FT /gene="SPAC186.09" FT /product="putative pyruvate decarboxylase" FT /protein_id="CAB75873.1" FT /translation="MKDNQQAVQLQQPTTIGHYLAVRLAQAGVKHHFVVPGDYNLGLLD FT KLQYNNYLEEVNCANELNCAFAAEGYARANGIAACVVTYSVGAFTAFDGIGGAYAEDLP FT VILISGSPNTNDIGSSHLLHHTLGTHDFSYQYEMAKKITCAAVSIQRPTEAPRLIDYAI FT KMALLKKKPVYIEVPTNVASQPCAAPGPASLITEPETSNQEYLQMAVDISAKIVNGKQK FT PVLLAGPKLRSFKAESAFLELANSLNCSVAVMPNAKSFFPESHPNYAGIYWGQASTLGA FT ESIINWSDCIICAGTTFTDYSSNGWTSLPPKANVLHVDVDRVTVSDAEFGGVLLRDFLH FT ELAKKVKANNASVVEYKRIRPESLEIPMENPKAALNRKEIIRQVQNLVNQETTLFVDTG FT DSWFGGMRITLPEKARFEIEMQWGHIGWSVPSAFGYAIGAPKRNVVVFVGDGSFQETVQ FT EVSQMVRLNLPIIMFLINNRGYTIEVEIHDGPYNRIKNWDYAAIVEAFNAGEGHAKGFR FT VGNGHELAEAIRQAKENSQGPTLIECNIDQDDCSKELINWGHNVGAANGKPPAKE" FT misc_feature 28117..29676 FT /note="Match to PF00205 TPP_enzymes, Thiamine pyrophosphate FT enzymes Score 602.53" XX SQ Sequence 30176 BP; 10150 A; 4861 C; 4948 G; 10217 T; 0 other; atgattattt gttgtcgatt tataaaaaga catttgtaat cttttgttaa gccgaaatgt 60 ttattaaaaa ttttatagat aaactatccg ttttaagatc atttttatat gagaataatc 120 tttagtaaga ctattttttt ataaaaaaaa gctttgaaaa aaccgtcaag agtttagcta 180 gatgactgat ttatagaata tatctaacat aagaaaaaat ccttcatttt tcgtaagtat 240 tttatgatat gacttatttt tcaataacag aattaacttt gttttaacaa tacatcactg 300 cttacatgcg agcttcacaa agcaagtatt cgtctttttt ctgcgaattt cattcgatta 360 aagaagtgaa ctatacattg ttgagttcac cgaccctaac cctagacaaa ggaattgggt 420 aacatacatt gattattgtg ttttataccc tatcaaaatt gtttgagtaa cttgaagtgt 480 aaaatgaata aaagataaat tggtaataac ttgctttagt gtatttcagg ccgatttaag 540 taagttttta atagtgtcaa accaagtttg ctcacccgag ggtgttctgt gggaatctgc 600 tttgtttttt aatagattat atagtttggt ttgtaagggt ttatgaacgc taaacaatat 660 accgtttgta cctagcgggt aggtatcaca cgccgttccc gtgggtccag atgacagaag 720 tgacgggact gctaaatata gcggatcgtt ttttaacgat gaaccttttt cttatccgaa 780 tttcgagcta aacagctagg tattaggatt tagtgaagtt tcaatctttg gacgtacttt 840 aacgggaaca caattgaatt atggattaca gtgggatact taagttcaag ctttgagaaa 900 acgaggaaag gcgttaatcc tttgtattga caataagaag tgatgctcaa gaaataagtt 960 ttaatgctaa gttgattgaa ctggtcaatt aatatttgat aaattttttc aatcttattg 1020 taatttgatg cattaaggtt cgtataaaca gcttttcgat agtttgtgaa ataaaatgca 1080 gaagtactca gtagtctgtt acagaattta tgtttttggt gttatttgaa gacaaaacct 1140 taatggattc gttttatacc tgtaaatata ctatccaatt ctatcaaacg tacttaaaaa 1200 caaataccga ttcatagaat ttgttacgat gaaatatttc taataatagt atactaattg 1260 caaataattt accaggtcca aagtcattga tctggactat attgacattc caaatattaa 1320 tagtatgtct tagcgtatat aaaaattaag aagacttcaa cgctaagtat ggattcagct 1380 ctttattttg ttataaaaaa ataactcaat gctaaacaat aaaatagccg agcagttttc 1440 aattaagaat tgtctagcga aatttcatta aacaacctaa atcatatgga gtttttttct 1500 tttttgatat ttggctcagg caaagaagaa aagttaagag tggtatttct taataaatta 1560 atgtctcaaa aaaggaataa attttttttt taaaatgcta aattttaaac gtcctcagtt 1620 gcatagatga actttaaatg ataagcgaac gaaatgcaat cgataaatca ttgtctctta 1680 gtaaagtgtt cggttaaaat gactgacatt tcgtccgaaa taatatcagt gtaaatatca 1740 tgggaaaatt tcgtgtattt ctttatttgg aatgcgcagc aaagtatcaa gagaataatt 1800 agtgttttat atgatttaat tttattgccg gtacaattgt atggttgttc tgataaatat 1860 acatgctttg tcggtttatc actctgaata aatttgtgat atatattggt ttatttattc 1920 aatctatgta tcatgtagtt gatgctttca tttttttcat aattttaaaa atatcagtta 1980 atcatttatt cagcaactgt aacgttaaat cattaatata tatatctata tcggcatgca 2040 ttaagttgct accgttaaac atcttaatta aaactagtct tttataataa ctaactcttt 2100 aattttttga aattagttca atttactgtg gagggcagtc gattgataaa agcttttcga 2160 ttcacttgta gctttaatcg gtgctcgttg catcaatatt ggtttatata agccaaagct 2220 ttcatggcta ttaatgagtg atgccggttt aactactcta aaatgttttg aaaatgatag 2280 gtatgttttg atttgcttca tctttttatt tcagtattaa caacctagta attaaaatgt 2340 taacaaaaaa atttgactac cttttcgaat cacatgtttt cagtgctaag ttgcctccag 2400 actgtctgca gtgagtatag gtgttttata agaaatttgc tacatagtat caaatcaata 2460 atatgaatgt agttttatca aaaaaatatt cattaaggcg actgtactga aagagaagta 2520 ggttaataat agactcttaa gaaaattaac gagaggcgtc aatttctgtt gctagcatat 2580 attgcgaact cgatcggtat gtgaattact acgaaaacat gcgagccgcg ttaacaaatg 2640 tgcattgcct tgtcttaaag taactaagtt tctcagaagc agtataaata gtagactaca 2700 ttaatttcga agttccgata atgatctttt tatagaactc aaatttttta atttgatatt 2760 gagaattcga ataaaaataa ctatgggatt aacaataagg gggtttccga aattttgggt 2820 actggtttta tatgcgcagt ttttgtataa atgaacaggc cttctcacac gtcttttcgg 2880 ttcatattta gcgatcagaa gtcgttaaaa atttttctcc tataaacaat gaatgtggtg 2940 aagtacataa tttttagctt tgctctggcg cctttgttat tagttaacgc gaacacatat 3000 aattttacac agatacaaaa gcgaagcgta aaccaagctg ttcttgaatc aagtcaagat 3060 accaattcag taggcggtga agcttcttca acagcttgcc ctttattcac tactatttac 3120 actaatggta taacaccggg aactacaacg atttatccaa catctatctc gacatctggc 3180 gtatctagca acaatatcga tgaaacttcg gtatcctctg agtctatcat cacatccact 3240 attacgacta ctataacatc tggttcgcaa ctctatacta ctaccattac cggtcaaaac 3300 acacctgttg ataccgttga agtggtaatc cctactgctg gtactttcac aactacattg 3360 acttctggat ccagttatcc tgtcgcaaca actacagtgc gaacagcttc tggaacacag 3420 tcaggtgaag tggaggttat cacaccgtcc tgtggatgca gtcctgaaaa ttcattccat 3480 cttaaaatag acaatgataa aatcagccct tcctacgtgt acatggatcc aaacgcaccc 3540 gtgagaacta atggtgccgg tcgagagggg aatatgtttg cttcaactaa tggagacaac 3600 gagggactaa accttttcta ctatgattcc actattcaac gagtattaac atgtgattgt 3660 caaagaccgt cttacactgt atacattgaa gatccaatta taggcaatgg tttttcaagt 3720 gcttggaatc tcattaaaaa tagcgatggc atatttactc ctgttgaatc aagaaataat 3780 gagccactac actttcatgt agataacaat ggaagagtat ggatgacttc acaagaatat 3840 gatacagaag tttcatcaac cgacgaaaga aattttaggg ccaatgatgt tacacttcaa 3900 ctgtattagt tgaagcagca aatttagaat tgcacatact ctcgtttaat tttttgtatt 3960 tcaggtcata catataattt tttttacatt catttgatat aatattttaa aattacaatc 4020 catgaaatcc tttatcaatc cctattgaag atgtcaagaa gttgacttcc tcggatttca 4080 tatttttctc aagttctgct gtaaactgaa aatagggata tttaaatagt tcttaattat 4140 tttttccact agaaattgat tgctctacta ataaaatact gttccaagtt atcggcacaa 4200 ttattacttt cgtaaacaaa atttgtattt tatttatttt tttttttttt aaattaatca 4260 taactagtgg tattaggaat gcatatttta atctaagttc aaattaattg ctttcatagt 4320 aatcattgat atttgttaaa taactaggtt taggtaaacc gtactaaaat tgaacaggaa 4380 aggataaatt ttagtaaatt ttgtagatta tgcttttcgt aaaaaatagt ggtggccggt 4440 tttaaagata agtttggata aactggttat aatttcctta agtgaaattt aatcacttaa 4500 aaaaatatta gatctaaata gtaactatag acaagttttg tataaggaaa atgacaatta 4560 aagataagga gctagactag tctagcgctt gttttgagtt taatattaga ccattcagaa 4620 tttttttact cattattact aaaaaagaaa acttaagcaa gaatttaaat tgtggaaagt 4680 ctcttttact tattaataat tgtaagcaat aaggataaga aaatcaaaac agtttttttt 4740 aaaaatgttt ctaaatttaa aaaaaaatct aaaccatatg ctgcgttgcc tgtaaatagt 4800 gtatctaggt cggatgagat tattgttttc aactttattt cttcgttttg taagaaatga 4860 actatattgt tgtagaaata gaataacgtt actaatctct tgaatatggg ttaaaaaaca 4920 aaattcacaa taattagaaa attttttacc tttttatagt tttacccaat tatttactaa 4980 aaattattgt agcaactatt ttaaatagta aatggtggat tttctatcaa gcagtaggta 5040 aattattgca gcataatact gaacaaaagt tttcatttca ttttcaagta ctcacgaaat 5100 ttttattgaa ttgaaagaaa actattttgt atatgaaagg cgctaaaaaa ttatatcttc 5160 attatcactt ttgattcaag agactaatac taatttgctt atttatttgc gattactgat 5220 tcatcaagac tattagtata gaaatcggac gcactcttca atgtggtatg tgcaatggaa 5280 cagagagctt ctgtagtaaa aaacgcctga tgtgaggtaa ccaaaacgtt tggaaaatta 5340 acaagacgtt gaaacgtaga atcctttatt acttcgttag aaagatcctt ataaaataag 5400 tttctttcac cttcatatac atctattgca caacctccga cttggccgga gtcgatggcg 5460 tcaaccaacg ctttcgtatc aattaaacct cctctactag tgttcacaat tgttactccc 5520 tttttcatta aagctaggga gtcagaattc acaatgtgcg ttgtactggg cgttaatggg 5580 caatggaggc ataaaaagtc agccttcttt aaaacctcat tttgctcaac aaattgaact 5640 ccatagtttt ctaacttctt atccggattg atatcgtaag ctaatacatc gcaaccaaaa 5700 cccattttaa aacattttgc aacattactc ccgattttcc cagtaccaat cactcccact 5760 gttttaccat gtatgtcaca tccaagtagt ccgacaatat tgaagtcatc ttcacgcacc 5820 cgaacatagg cacgatgaat tttacgatta agagacaaga gtaaaccaac agtgaattca 5880 gacacagcaa aaggcgaata ggaggggacg tgcacaacag ttattttata ttcggacgct 5940 gcctttagat taacgttgtt gtacccccca caacgaagag cgaccaactt aacaccattt 6000 tctgccaaag cttttaaagt atcagcatct acttggtcgt tcacaaacac acacaccacc 6060 tgtgctttgc ctgccaaaga aactgtatct ttgttcaatg aaaaattgtg atatattatt 6120 tcatggttaa aagttttgtt agcttcttca aaaggccctc tatcgtatga ttgactacta 6180 aaaaggacaa cacgcattgt tggaagcaaa ggggtaaaat gttatgaata gaggaaataa 6240 aagttaaaag ctgagagata ctataaatag ttgttcagcg ttcgcaatga agttcttatg 6300 aatgatatta atcaacctaa tctttggaaa cttattacat ttagaaattt aatttgccca 6360 cgagaatata gtcgatattt gttataatat ttttaatacg tcaacggtat gtaatatatc 6420 tatagtattg cagtgatgaa agtgttctgt aataaatgat aaaattaatt tattattgca 6480 aagtaatata ttgattattt aaatttcttt ttatcttttt aaacaaccat atgatcctag 6540 gtgtatttca gaaactatgg ggtaactagg tgcaatattt tttatttttt attgtcgcca 6600 cgcaagtcgc atatcaacta ttaatgataa tttgaatggt cttgcatata caaattaatt 6660 ggtgatttga tgttttaaga cttagtaagc catacaataa taagaagtcg attgaatttc 6720 taaaagttta atcactatta taggtgcatc gacgcgatgc ttatgttcat aaaaaaaatt 6780 gaaattgctg tcaacaacaa tgcataaaca aactatttgt taatttcagt ataggaaaaa 6840 aaataaagtt ttcgaacata ttttggaatt gcggattatt ttaactgaaa gacgaaaaaa 6900 aatgtaaaaa taatctaaaa acgtctgtgg tgcatatttt gattttaata catctttcgt 6960 cacttcaaca agcactgcaa aactgatgaa attctttgat gcttcagttc ttcatggctc 7020 aagccactca aacaagcttt ctgaataaaa aaaaggttgt aaaaaaaccg acgacgtctg 7080 aataagcggt aactaaatat gaattttcac gaatttatag agaatacctt ggttattccg 7140 agttttaaca gaactttgtg tcagtgctat atttgttttt atacataaat taagagggac 7200 gatgatttac ttataatata gaacattgcc aaaaataaaa aatttagttg gatttaaata 7260 tccttcggac acaaatccat gttactttcg tagttgtaaa caatcaatca taccgtcatt 7320 atgtaatagt acgaagaagt accagaattt tttaaattat cagcaactag cacctgtggt 7380 cattttaatc tgatgatagt ttattctaat atattttgtc tataaaatta tgatttggta 7440 tgccgcagtt cgtataaagc aagtaccggt tatctgatat atgcggcggc aactagtaat 7500 atatataact accttaaaaa aatgtagcaa aagagtaaaa tcgtgacgaa attgttttca 7560 ctaatattaa cagtaaacat catatgttaa tatgttagtg gatttcgtta gttgctttag 7620 attcctgcta taaacgccct tataatctaa aatgtaaaaa taccaatatc aaattcctgt 7680 tgactgtacg tagtgaatgt ggacatttct cgtataatat tgttgcacaa ttttatttta 7740 actttcgttc gtctactatc aaagttatac ttcaattgat agtgaggtat tcattttttt 7800 tggatgaaag aaccatgttt gttgagtaaa cttatatgtt taacttatca ttatttttta 7860 atttcataat tacaatagtt taaacaaaaa gaaaaaagaa ggaataaatt ttttaaatat 7920 aattcctatt tttttagtta tttaagcttt taccgcttac taatttgttt attcaaagga 7980 tgataatgat tatctgaatt ccctatgctc ctttagaaat tatccggtta ttataatata 8040 caaatgtgta tcaatttatt tgtttgcggt acacaaaatc attaacacag tctttcaaaa 8100 tatctgaata gttatgtaag tcatctatcc ctcatcataa tttcattatt agattgagcc 8160 tgaaacactt gcttaaaaat atttttattc atttctgctt tttactgttt gctggcagtt 8220 tttctaagat tgaaaattag aaattcaatt ggtccttcat caattacgtt aaggtttttc 8280 tttttattcg ttttagagct tttatgtaat gattaccctg gacgttcctt atgacaagcg 8340 aataccatag aaactttatg ttagtctcct gtaatataat cttatcgaaa aagtattgat 8400 tacgcacctt tgaatatttc ttaacggatt tttatgctat tgtttgtcaa tccccagctt 8460 taccgttgct tatcacaaac tgttttcttt ctagccataa aaattttata cattgaggat 8520 taattctcct gtgtggatca ataattgttg atttatttct tatacaatta acacgaataa 8580 ttctgtccgc attgtccatt ttgttgcaga caagtttgta gatctgtcgc tgtcctatga 8640 aaccggctta ttaaaaaaaa cagctttaaa catccaacta tggtctttgc attaagtcta 8700 cagaaataac gttgcaggtc taatccttca tcttacacat tttcttactt tacataataa 8760 gagctacatt gaggaaattt atgaattaaa caaaacagta aaacttcttt acaggttgtt 8820 taaaaaggta cgaagttgaa caataaattt tttttaataa acagtatttc catgatgaaa 8880 attcaaagtt aaagactaca tttgtttttt aaataatact ttgttttaaa ttattcatta 8940 gacacatttt aattcccatt gatgtattta ttacacagca tgacttcaag tgtattcact 9000 aaagaccggt tactttaaaa attttttaat gggtttaaaa aaaaatcaag aaatttacta 9060 atataatgta taaactgata gctttaaaat ttgtaggata ctaacctatt gtacgtttct 9120 tttgagttgt tcgaacgggt gatgaccgct catacataaa cgtatgctta taaaatttat 9180 agtaattcag ttaacttaat aacttgtatt gaatactgtt tagtgtctga ccaatgataa 9240 attcatataa aatttctgtg ttaagaactg ccggcaaaca ttcacattta catttttacc 9300 aataattaaa atataggcga gtgttttttt agtaaacagc tagaagaaac aacaatcatt 9360 ttcatgtaaa atacagcaca atttgctcac gcttaaacac taccgctttg acagtacttg 9420 aatgatgctt ttttgtcgtt ctaaaattta cttcaaggat atcaaagcgt agagtaatgt 9480 atcttcataa ttttttttat tataattcgc ccttaaaggg gtattgaaaa tttgggcaaa 9540 ggaaactatc tgaacaattc attcatttca actccaaacg ttgcaaaaaa tcggcgacaa 9600 aattcgaaca tctcttgata tatagaataa attgtgaaaa aaaaaaaagt taatattgag 9660 ctattaaaat tcaaaaaaga cggaaacatt cgatgtgata cagaaattat tacataaatt 9720 gtagctctta aacggaaaca tgaggcccta tcagttgttt ttatccttat agccgtgatt 9780 gatagcttct gcattttttg gtgggcatgc aagtgtttgt gccaaacaaa aaaattaaag 9840 tgcgtaacag tcaaatcgga gaaattccat ttttcccttc tgcatttgta tgatgtcatt 9900 tcgtaacata atgttaaaca gagacattga attgcgtgag cccattcatg gtaggcagtt 9960 gtggtaagta aaggcacata cgatattttg ttatcgcgtt agaaaaatac ccggcgatca 10020 atttagaagg accacaatgt ttagcgcacc actctgcgtc attaatcctg aaaataacat 10080 ggtgttggaa cagtgattct tcaatgaaca actaatattt ttattttaaa ttacattttc 10140 aattgtaaat gcaattgtaa actctctctt agaaacaaaa atgatatatt acagtgaaca 10200 gcaaaacctc atcccgtcgt tagtgtctcc atctctcagc cgaaatgttt tataagaatt 10260 tcccatgcag caagcgcttt tccagagtgg aaataatttt gaatagccta tcttccgcaa 10320 aaaaagaacg gagataagac atatagaatc tttgattttt cttctttctt ttttgtatat 10380 ataataccca agttactaac cgtaaccttc atattaaacc gaattttaac caaaatgtgg 10440 agatcaataa tcagttttct attcttttct gtggcattat gtcagccatt tttgtttcag 10500 aagcgctctt ctaatatttc ggacttcatt tcatttaacg cctcacttcc caatgttacg 10560 atttttgcaa tgggaggaac tatcgctgga tatgcttcat ccagcactga aacagttgac 10620 tatgccgctg gctctgtagg aatagcaaca ctggttgatg cagttcctgc tatcaagaac 10680 ttttcaaaca ttcgtggagt ccaagttact aatgttggca gtgaagaact gacacctgct 10740 aacgttttga atcttactca gttgattcta gccgaagttg ccaaacccga tgttcatggt 10800 attgttgtta cacatggtac agattcactt gaagaaaccg cgatgttttt ggacatgact 10860 gtcaatacta caaagcccat tgtagttgtt ggagcaatga gaccttctac tgcaattagc 10920 gctgatggcc ctatgaactt gttaaatgct gtagtggtag cggcctctaa tcgatctatt 10980 ggtcgcggta ctatgatctt attaaatgat cgtattggat ctgcctttta tactacaaag 11040 acaaatggaa atatgcttga taccttcaag tcatatgagg caggattcct tggtatgatt 11100 cttgatcaaa gaccacattt cttctatagc cctgctacac caactggtaa agttcatttt 11160 gacgttagca acactactga attaccagca gttgaaattt tgtatggata tcagggactg 11220 aatcctaact tggcaaaggc tgcagtagat ctgggagcca aaggtttagt cttagctggc 11280 atgggtgcag cttcctggac ggatcctggt aatgaagtga ttgatggatt gattagtaac 11340 caaagtattc cggttgtgta cagccacaga acaatggatg gattttctga ctattattac 11400 aacggaattc cttcttattt ccaaaatccg caaaaagcta gatatatgct tatgctttcc 11460 atcaacgctg gctattccat tcaaaacatt actgatatat tcagccttga gtattagagt 11520 ttttttttgg tgttgcttat caactattcg atatttctaa tttgaacata gaaaagcgag 11580 tatactttgt ttacgaagtg ggacttgtta aaattaaatt taaataaaac tcaagtcaaa 11640 cttatctctt ttatttgcaa cagagcctca aatttctata cacctgctat ctttccagta 11700 acataatcag cgtggtagaa ttactccttt atgaaataaa agtagtttgt agtcagagaa 11760 aaaaacttta gtgttttata aaaactacga aagtgttgaa taattaactt aactcatctg 11820 acgaaattat tagttttgaa tgttaccgat tgctattaag aggggtttcc tttgtaaata 11880 caaataatta tatatgatta ttcataacgt ttaaagttga aaaatccttt ttatttttca 11940 acactttgta agtaaacatt caattcagtt aagaattatt tcagttactc gtttgtttca 12000 attttataat tcaaataaat attaagcaaa tttttacccg tttgatgctt tctgaaacag 12060 ttttcagcag cttcacagtt aatttggcat ctgactagct tcaaactatc actatttcgt 12120 tgaaaggact tgccactaat ttcacaaaca atccacatat tcgtgatact ttgtttaatt 12180 tcagattaga ggaaaaaata agaaaacctt ttttaagaag atagttctgc aagaaaaact 12240 atggtagcct tgcaaatggt gatttgacgt ttagtatagc attgatatag tgttgcataa 12300 aagtaagtct acggtctttt tctagcggtc gtacgcataa gcttcatgct gtagtttaag 12360 catcctcata ctacaaatat ttaaatgaag taaatgttag ctcatgtctt gtactttgct 12420 aaaaagctgt gcgctacacc cttaataatg gtcactagat gtgcggtttt attaatttag 12480 cggcaccaaa acgaacaaaa catagctcct ttactttaac ttctttagta aagcgaaaaa 12540 aaatttaaat atagtaaaca tgaaatttca ttcatcacga aagaagcttg acgtacttct 12600 ctatcctttt aagttaacaa aacttgaaac agtcatgtaa aatttacgga tgtaaaaaaa 12660 ttattcaacg tcttaatata ataaaaaggt caaaaaatga ttattcgggt gtaatatttt 12720 cttatataaa ttataggatc aacttcttaa cttcaaagta aaatttcgtt ccaaaacatc 12780 acctaattag tcttgtcaat ttgaatagtg tttttttttt cttgtctcag ataattgatt 12840 gcaaacactg ggccagtata ttactaaatc agaacaatta ctccggcaat atcaacccct 12900 atgatattcc cgaacaccct acttccacca tacagacata cgacattcta cacctcatgc 12960 taatttagat ttaagttggc aggtatcgaa gagtcatatt agcagtcgca aaaagtaaat 13020 taataaaata caaacatgcc tcagggtact ggtgaatggt atcataccaa aacagctgtt 13080 ccaaaaaact tacaaaaaat gcgtttcctt aagtcgtaat gttttccatt gaactacaaa 13140 caactacttg tagccgtgct ctgatatcct aatatccccc aaattcagta atcaaactct 13200 ggtggtaacc ataagcgagt acattttttg gaatgcaccc tagatttata agtagacaag 13260 atagacacta ttcgcgaaga aatttgcgaa ttatggctaa tgagatagtc gtagctggat 13320 taacatcgct accagattta tgcacgctaa ccatcaaaca aaagccccaa ggaaaagaaa 13380 gagattgaaa acttccaaca ttttctttca tagaagtagc ttttacttcc ctacagcaaa 13440 gacatccaaa cttgagttcc cgaaaactca gcagaacctt aagaagcaaa tgcctaattt 13500 gcaccagtag ttaaggaata aaaatttgtt tttgctacac gaattaaaag tgacttcatt 13560 aacttcttta tttataatca gctggcagtc ttaacttctt ctactgctat gtaaaactga 13620 ctgctgtttt tgaatcacgg aaccacattc gtaaaacgat ctacgttgta atttcataag 13680 agtaaattca attgagtata accttacacc ttactatggg cgattgatga tttgtagaaa 13740 taagaattgc tttgaactaa agcctacttg ctctaccata aagactgaat gattttcatt 13800 ggctagtttt tcatcgttta ctctgatccg tgacattaga aactgcgttt tttattttat 13860 ttttccaact ggatgatcca tccatacctt tcagagaaac tgaagagtta gttctggagt 13920 ttagtctaga atttgatact gatgaagctc tagaacgagc ctctagtttc tcaaccacag 13980 aattaccaag aacatgcggc aaagggccac tcaaactcca caccggcttg ttgggttttc 14040 ttcgcgcatt taattcttcg taaagaggat cgacaaaatt tgaacgagga gttttagaat 14100 tatcctcaag ttttccagcc aaataccctt caagccattg ttgagcatct gggtctgcaa 14160 atttgcttag gtccttaagg tttggagaag agatattcat tttcaaggca tctttaggtc 14220 tcatttgtcg tgtaagatta acataggatc tttttgaagc ttttggttca ttggatcggc 14280 catcataaac gtgcgcatcg ttcgatgatg gcaattgaat tcgtgaagaa gtgttcatat 14340 aatatagaat gaagaggaat gacctcaact tatatggaaa tttcacgata cgtatttgga 14400 tacacccgga cgaagtttaa ttgatttatg aagaaggtgg ggaaattttc ttacaacttt 14460 ttcttttcga ttttttaaca aaatgcttgc gctttagtaa ggaaaaacta ttgaaacgta 14520 tgaagttttc tttatgattg cttccacaac agataatcct ttagtatacg cattcgcata 14580 tgtgcctatc ggtctcaagt attaatgtgg acaatgtaac cgatcacctt ggttatataa 14640 tttacagcac aacctctttg tactcggtat ttcacagaat ctgaatgggc cgtggatagg 14700 ctaatataat cattgaaacc ataggtggta gtccttttgg atcgtgtagt cggttcgcca 14760 ttttttattg acctttatgt cattatgtca ttataaagag gagtagctgt acttcatccg 14820 aagttcgctt agtgggcttc gaagtactac tagtcgactc ctaatggagt tttaagtggg 14880 gtcaggttca ttcggactcc attagagtct atctctcatc tcaagagttt ccttttagta 14940 aagagtaagt aagtactgtc aaccaacttt tctaatttgt agctctcatt atttttaaag 15000 aagcgatcta tgaaaaacgt tgcaatggag ttagtatggt ctttagagta attgtatagt 15060 gacaaaaaaa taaataaata aataaagaga aaaatacaat taatgagaaa attgtaaata 15120 agtattgaat attgatataa acaagtttta tcaaaaacag aatatgtcaa aaatgcaaat 15180 aatagtataa ataatttcta aaatatacat ttgtacaaaa gtagctatta aattactaat 15240 tccatatata gtatagtact tgaagtaacc agtatacagt taattgtacg aaactattgc 15300 attgaagtta ttaaaaaata gtatcaaaat acagagaatt tggtgccaac tgacagataa 15360 attagcaaaa taagtcattt ccgatcaaaa taattttctc acaacgagta aatggcattg 15420 cttttttaag aatttaaatc ctttggaaaa tctaaataag gactttaaag agtcgtatgt 15480 taacgctgaa agcattatcg gaaggtataa aacgtagcaa ccgttgaaaa ttatttcttc 15540 acttagctat aaaatatcaa agtaataaaa attgtaacca tcatcatcaa aagccttgaa 15600 aaatgtacag tatcccaaaa atcatgaata caatccctcc aaagaacagt accttataca 15660 tttcgatttt atttgatatg tatcttccga caatcaccgc taccattgta cacagcatat 15720 gaccaatatt caccccaatg aaaacatcaa gcaccttctc ctttgccgac ataacaatgg 15780 tagcaatttg agaacgatcc cccaactcac taacaaaaat tagtgcgaaa gcttttatga 15840 aagcccggga aaattttttc gaaaacagat ttttaaaaca gctcatacta aagactttga 15900 aaaatttgtc tttaagcgta gagctgcttc tattgctggc tggtaatccc aattctaatg 15960 tttttttcat atcttcttcg tttacaataa ttttttcgac tttgtcaaat tcattttcaa 16020 gagactgttg actttctctg acctctttac tctctttcag catttttacc ccaaatatca 16080 agaatagtgt tccaccaaga atatgtgtta tcgatttagg gaacagaaaa ggggcagcac 16140 gcccaactaa cacagcaaac gaagtcataa aaaaaagagc caaatatgaa ccaaaaaaaa 16200 cggatgcccg tccatattgg tatgccaaca gagcagtaac gatgaaagat ttatctccaa 16260 gctcacagcc tatgatcatt gatattgaca ttccaatgtt ttgaacggaa ccatgactaa 16320 actgcaaact gcctaaagta gtttccaaat ttaagggact ttcaacatta atcatgattc 16380 atttacgtta gagggtaaag gaagataaaa caatgaataa gcaataactc taatcgacag 16440 ttatttgaag cttcactcaa taaaaatcta aaatttgcaa ttcaggtggt taggcacaac 16500 gaaagttggt aattgatggc caatgctgat aacgaatata atgatgtctc aaacttaagg 16560 ccttctaaaa tacaaacaaa aaatttcgat gtttaaaaca ttatcgaaaa ttacaacgca 16620 cactttatgt atagaagaag ttgagtcacg gatgatccaa tccgaagctt aaagaaacaa 16680 aatcgttaga ttctaccaac acggatgtgg gaaaacttag cttttcaccg gaaaaaaagt 16740 aatatataag catgggaaaa ttaccgacca tttttatttt gtcagctagg cagtttggta 16800 tctgatttaa ggatacgtag aaatgcggca agttttcctt gtgatctatt atattgcgat 16860 acacaggtag tagaagtagc agatgagtat aggcattgta ttatctaggt tataatgtta 16920 ccaataactg atattgctta taacatttaa aatagcaaca attttaactg atagttagtt 16980 actttatcat aaatgatatt acaaccgtat taataactta ttatgtgaag ttgatagagc 17040 aaatagaaca ttatgaacat gtgacgtata atgatacgca acgtagtgac tgtattaaaa 17100 attttacagg aaaccaaata gtgataatcg tagcacgtcg aacattaggt ttcactattt 17160 ccagtttatc tttatacatc agtagacata gctagataag agtttcagat tgtatcttgc 17220 taatcaaatt tttttaatat ataaaccctt ctcagttaag ctgttgacaa aattatttag 17280 ctttacttaa catagcttta tctgcacgaa tggcattata tccattcagg caagtcgatg 17340 tgttttctac taaaggatac gctggtaatc ctctggcagt ttttttggac gctgacggtt 17400 taaacagcac gcaaatgtaa caaatcgcta agtggaccaa tctatccgaa acaacattca 17460 tacagaagcc taccatccca ggaacagatt acagaattcg tatattcaca ccgggttgtg 17520 agcttccatt tgctggtcat cctactatcg gatcatgctt tgttttgttg gacaataagt 17580 cttgtagtgc caagaaaaat aaagtagtgc agcaatgtaa ttccggcctt gttgaattga 17640 cgttacataa cgaagatgtc aatcaaactt ggatatcttt tcaaattacc gagttataag 17700 acttcaagta tctcaccaga agtaatagta gatttggaaa aatttttgaa tttatgtgaa 17760 ggttcatgtt cacaatgcaa tactcctttt tgtgtagatg ttggtccaag gaatgctata 17820 attcaactac ctaacggtgc tgatgttttg aacttgaatc ctaattttca agctattttt 17880 gagtgctgtt caaaaaattc gttgactggc gtccaaattt ttggaatgta taacgacggg 17940 acatacgaac ttagaagttt ttgtcctgtt catggggtaa atgaagatcc tgctaatggg 18000 agtggagctg gatcagttgg tgtatttttc gccctcaata atccatcaat aatctcttcc 18060 gatttcgctc atttattatt taatcaagga aagatattag gcagaaatgc tttaattcga 18120 gtagctatca agttgtctgc aaacggatta tacgatattc atgttggtgg cggatccaaa 18180 atctgcattt ctggaactgc agaaatctga tttttattta acaaaaggac tgataaaata 18240 ttcactcgtt aagttactga taaatattga aaatattaaa aaaatgaata gggtttgttt 18300 tatatcggta tcctaaaata gcaattaaaa atagtgatat tcaatatgta ttgatcaacg 18360 gattttgaat ttattattca ttattttttc atttcttttc tttcgataaa aaaagtgatt 18420 tcttaaccaa aatcggttct gatttttaat gaattagaac atcgcccata taacatacca 18480 catgtagagc atgttaaaga tgttttacag agactgaaaa atgcacattt gattatcaac 18540 caagcaaaag cgcaaaattt tacaaactaa caaatgaatt tgtagggtat catatttatg 18600 aaaaggaatt tacattttgt caagaaaata tagacaaagt cctacaatgg aaacaaccta 18660 agaattgtaa agaataccta aaatttctag gttctgtcaa ttatctaaga aacttatata 18720 atctgcaaag tcaaataaac aacatatcaa cagaaatacc cttgccatca ttaaactact 18780 caaccattga aaatttattg tatttacctt attcatacct tttccctttt tttaatacaa 18840 aataagtgtt gggttatacg attaatggct ctttattaga tgttttagtg ttcgggtatc 18900 gggactttgt atattccata ataataatag cgtgaaaagt tatattgttg cttatcattc 18960 gaataaagtc ataataatta aattttgttt ctttgactaa atacaatttt tcggttgtgt 19020 gtattgttaa tgtaaattgt tatgaacgaa ctgaaccaaa acttagatgt agaaatttat 19080 tcaggagtgt attacactat atttgttgaa ccctttaagc gctataagtt ttttggatta 19140 ttttatataa ttaaataaac ccgcatatgc attagagttg ttgggcaaga taatgtgaca 19200 tattctgaat ttctccattc agcagcgtat gcgacctttt ttctaacctt ttttaggtaa 19260 aaaataaata caaataaaat gttaaactta atctttgtat caaataagca atacatataa 19320 ctcttaaatc gctaaaactt tcatttttta taaccttcat tcttccattt aacatattat 19380 acgatatgac atatttggca tgttaaacgt gattatattg attgtataga tgaagttgct 19440 gtaaaattag ttccactatt actacacaat gttatatagt gaccaaaccc gttaattata 19500 cactacattt ggaatttttg ggataataac atttatgata gctattgaat tttaaacttg 19560 tactatttac tcaactatag gttaatagtg agccagatgt acgataatac ttagcgaaaa 19620 catactaatt catcagtagg tccgctcgcc ctaccagagt tcggtaactg taaataattt 19680 gaaccatcac tgattgaggt agagtctgaa ttattttaaa gaggaatgtt gatctaatgg 19740 tttaatgaaa atgaaaactg tgacagtagt aacttaggcc aaattaatac ggcttatatg 19800 gaatgtaaaa cacaatcgtt gaaccaggct acaaagtgca tttttatcca gaataaagcg 19860 gcattagtca aatacagatc cgcaaattta ttctgccatt aatgtgtcgt agaattggga 19920 tgatatgaaa gaagtatcat ttgaatttta atttgtcttc cttaagattc ctgtatgttc 19980 acttatcaaa gacttttttc taataaacta acgtgatgaa tataaagtat aaacaagtta 20040 acaagtctta taaaataaag ttcgatcaat ccattaaata ttctaaattc aattcatatc 20100 acacattcga aagatatgaa ttaaaaaatc ttagtgtaaa taaataaatt ggaggattga 20160 atttttcaat tgatgaacat gaatgcttag taaaaataga ataaagtaat tagtaaaaat 20220 ttttattctg ttcgatactt ggatttgaat taaggtatgt aattaattga actgatatac 20280 aaaatttagt taattaaaaa taaagaattt tttttaacaa tttgaccttt ttttcatatt 20340 tgctttcaat aaatttgatg gattagcgcc tcgtttagtg tcggggagct taaggaaaca 20400 ataagaagta aaagatcaat cagttcgaac tccaatgtcg ataatttgat tgtttaaagg 20460 aagtgttcat agggggaaga gcaataaaga aagaattatc gagatactga tttaaagtaa 20520 gaatgttacc ttaataggtg catacgattg cagacctcta cgatagcact ttgagtggat 20580 cacgattcaa cttagtattt tattaacttc aaagcaataa ggaaactgca aaactttttc 20640 atcatttacg ttttcattga cacagcaatt atggtttaac ggtgcagtat tttctctcgt 20700 tatgtacgtt caagtaatag ggtattataa gtttttcaat atgatatttc caactcaaac 20760 taaattctca tttaagataa agaaattgaa aaggctaaat ttataaagga attactttaa 20820 gaaataacaa caatatcatt ttataagttt tttaattctt gacgataaca gatggatcat 20880 tgttttgcga tgcaaagtct gagacattct ttaaagttgt gtgtgcaatc gcagaaagtg 20940 cctccgcagt gaaaaaggcc tggtgagaag tcactaaaac gtttggaaaa tttgccagtt 21000 gttgaaaagt agtatctttg atgacctcgt tggacagatc tctatagaat aagcgtcttt 21060 ctccctcata aacgtccata gcacagcccc ctacttggcc gctctcgatt gccttaacga 21120 gcgctttcgt atccaccaag ccaccgcggc ttgtgttaat tattttgact cctttcttca 21180 tagaagctaa caatttctcg tctaccaagt gttcggtatc tggtgtcaat ggacagtgta 21240 agcacaaaaa gtcggccttt gctaaaacct cctgttgttc aacaaactga attccaaatt 21300 tctccaactc tttattgggt ttgatatcat gagctaaaac ttcacaccca aatcccaact 21360 ttaggcactt tgcaactagt cctccaatgc gtcccgtacc cagtaatcct attgtcttgc 21420 catgcaagtc gtgaccgaga aggccattaa gattgaagtc atcttcgcgc actcgaacat 21480 acgcacgatg aatttttcgg ttaagtgaca ataagagacc aatcgtgtat tccgctactg 21540 cgtaaggaga ataagcagga acacgaacga cggtaattcc attatcagca gccgctttta 21600 aatcaacatt attgaaacca gcacaacgaa gagcaatcag cttggtacca tttttagcta 21660 acacttttag tgtatcagcg tccactttgt cattgacaaa aacacataca acaggtgctt 21720 tttctgcgag gacagctgtt ttcttattca atattgattc atggtagtca atttcatgtt 21780 tgtaattttc atttaccttt tcaaatggtt ctttttcata tggctgagca ctaaaaaaag 21840 cgatacgcat cttttaataa attgcttaaa taaataatgg gtaataaatt tctaagtaat 21900 aatcgaggtt cttcaaatct cctgaacaaa ttagtagata gtttcacgaa tattggaact 21960 atttataata ttttggatat atgaaacatc ataatagaaa ttttacgagt gtttaatgac 22020 gatgtgtttc caggttaact cgttcgtttt gtacgtcaat gaatgttgca tattctaaac 22080 actcggctgt acttacaacg gatcccctct agtcattttc ccaagaaaat tcagaatggc 22140 actcattctc ttatggaagg tttagcgtta tcaacagccc atttattttt ggttaaacag 22200 gtattgaatt tttggaattc atgaacattt gcatttgtga tgactttaga agcatgcttt 22260 aatccgaaaa accactttag tctaaacatt tttggtataa tttgtggaat cgaaataaaa 22320 atatcgtaat atacaattat gcgtcattta taatagaatg aggagcatgt tactctctat 22380 gaggtaaact atttcgctta aaaatttatt tactatattc gttcaatagg tcacttgtgt 22440 tttctaataa ctgaatgatt aaaaaaaaaa aaaaaaggcg attgacaaaa tacatataaa 22500 aaaattgtat ttggaagtga aagtaaaaat attgcagttg atatggtaaa ctaactataa 22560 aaaaccagaa agcgatagca taagtgtatt cgaaatattt taaacgggtt gtagcggaaa 22620 cacctaaaga attggatggt aaaaaagggg gcaaggtatg taagttacaa gctacgtgaa 22680 aagatacttg ataaaataat ataaacaaaa aatcgttata actgaatgga agcgttgttc 22740 atccgttgat tatcgtcata aagtattata cctcatctaa catatatata tatccattaa 22800 tcaatattcc catatcaaat gtaaccgtaa ccatgaaaaa catgacacac aaaaaagaag 22860 catatttaga aggaaccaac taagtaactt attactttta ctttttcctt tatttaattt 22920 acctcaattt tatttcactt tcttagcctt aacttttctt tgtagagctc tcaactagtg 22980 gtgaaaggaa gggttaaagt gagagtttct ttattattat tattatagaa tatgaaaatt 23040 cgattattca aactgtaaac gtaaaatcaa acattttttt tttaacaaaa aatttatggc 23100 gtaaaagtat gagttattct caaagcagtc aatctattca caggtaattt cttctttact 23160 agtcaagaat caaatgtcaa cttgcaacac tctcaacaaa gttcaaaagg acttcagcag 23220 ctaagttgct tttcaaacta tacaagtttt gagtccacat agaaaacaaa gaaaatgggc 23280 taatttgaca aattcaccgt gtatgtaaga tttttttttt tttggtaaaa attataggta 23340 actaacaatc gattgtacta gaacatggtc tgtcaaatgt gatcttatcg gccgaacttt 23400 tttacctcaa gtcttaagta gtactgatag tcaaactttt gaatagaagt gtgtatctac 23460 tatttttttg gggggggttt tttatgtaca ggctcaacaa tgtatatatg cagtaaagat 23520 tatgaacctt tgtagtcagg attatcataa tttacttttt aaaactaata cataatcggt 23580 acacaattgt tgcaatagat attcaaagga tttctttcaa ttttatgact tcattgtcga 23640 ctgattagga atatagatga tacattgaaa attggatttt acgtaactca tgccaggttg 23700 cttttcaagt taccgattta gtttttgtag accaacgttc caagccactt ttttaaagca 23760 gaaagagatt gatgtctttg cgaaaagatt tgaactttac agaatagtag acagaatctt 23820 aattttcaag gcggataact aaatagtcga ttgcggttgc aaataatttc cttactaaat 23880 atttgaaaca atcttaacgc tcttcatggc aaggtgtttt gcgaggtttt tatttcgtca 23940 aaatacatga tgcattcttg atttattcag tgaatctatt atgaaaaata gtatcagctt 24000 atcactaacc atttacttaa actcgttgat ataatgaaac caagtatgtg gtttaataaa 24060 taattataat aaattcatat ttctatcatc atcagctgtt aagctactaa tttctaaaaa 24120 tcaatttaaa ccaatcgatt caatagcatg cttgatgctt ttcacggatt ctacaagctt 24180 ggcatcctcg tctttggaaa gctttgcatt aattatgcga tgagcaccat ctttgtttag 24240 ctttcttggc atactaaagc aaacatcacc aatgtttgag taagaatcta atccagatac 24300 tgtcaatagt gcattttcat cccgtataat tgcagctaga atacgaacga gacctgcagc 24360 aacgccatat tccgtggatc cttttctttg aataatatca taagcggcat tttttgtttc 24420 tttaaagcat tcattcaatg cttgttcatc atacttcgtc tcagattctt cacagaaatc 24480 tgcaagtgaa agtcctgcaa tactggcgtg ggaccataca gccaattcgg aatccccatg 24540 ctctccaatg atatcggcat ttacactttg aggatcaagg ccatataact ttccgataag 24600 atattggaat cgtgcagtat caataattgt tccggatcct atgactcgtt cagctgggaa 24660 tcctgtgagt tttaatgtag cgtaagtaag tacatccaca gggttggttg caactaagag 24720 gatggcatct tttgtatatt tagtgacttc tctaaggatt tccttaaaga tggaaatatt 24780 tgctttaagt agatccattc ttgtttcacc tggcttttga ttctttccag ctgtaattac 24840 aactgccgtt gcgtccttac aatctttata gtcacccaaa tatacgcgag tctcatggga 24900 aagtggagct gcatgattca agtccatagc ttcaccttct gctttctttt tgttcaagtc 24960 aatgattacg atttcagcag ctaatccact tagtagtagt gtaaaagcag tagttgaacc 25020 cacatttcca gcaccaacaa tcacaatttt aattgactag aatattaagt tagaactata 25080 ttccctttcc tttattgaat aaaacgattt agtcaagaat cctataagtt tgtttccact 25140 tgcaatgccc gtttcacttc gagaaggaac aagtgtgcaa tatgtcactt accttgaaac 25200 ttgatgaacg aacagaatcg ttgctaaaca ctttagaacc agcggtcata ttgttatatt 25260 tcttgttatt cttatacgct tgaatacagt ttgttttgaa tgcagttaag tgttaagatt 25320 gcttgtttat atatcttttc catttcacta ttgaatatgt aatttgattt ttcttcatgt 25380 tcattcacgt aaccattaca attcctttag accaaatgtg tagcataaaa aaaaacctag 25440 attcattaac catcccttgt aaccgttacc ttccccaaat aaaatttaaa aagcgaacaa 25500 atgacgagaa agtattcgat gccgaaaaca taaaggtcat tttgaactcg ccagattgga 25560 acaatgtggt ttgtagaaga atattgtgat attagaataa atcccaaaat gtgtatgagt 25620 tgacagtaaa aagtcttggt tagaaagagt catgtcgtgc taagtaatat tatattgtct 25680 tttagaagat tatttttttt gtctgggaat ctcattattt gtcaaattta ccgttttttc 25740 tctttttact cggatgcgtc atttcaccag tagaattgat taattcttga aggaaataac 25800 atgatgtttg aaatactatg tctgcgtcac tacaaaaatt gttaaaatat gtaaaccagt 25860 ttttacagta ttgattttac gatttatgga ataatgttaa aatgtttatt tatttattct 25920 ttttgggttt gattcattac aattataaat tttataaagc agaactgact ttagaattat 25980 tttgtttgta caataaactt cattaaattt attcacgctg ggtgtttata atgctgagtg 26040 tctcgttagg cagaaaatga tttctacgaa taatattgtt attagagagt ttgatgtcgc 26100 ttagttgtaa gcttggatta gtgtcacgag tagcagttgt tttaattggt ggtttggaat 26160 cctccgtttg ctacttatta tgattattat cattatttat ggaatattgt ctaaggaatc 26220 ctaatgattc aactttacga tatttatgag ctttttgctg gaccgttagt ttaccatgta 26280 actttttttt atgtaaaaaa taaaaatgtc tggaatctat taatgatcta aaagtagata 26340 aaagtcattc gagtacatta catgttttgc atgccaatat ccccaacaga gctacgattt 26400 tagacgaaag tttacgtctt acaacattac aagtatcatg ttatctcagt tgcatcgcgt 26460 atgttgtata gcaatgttca ttacaataaa aaaaaaattt cctaaatagt gttcgtctat 26520 tgctaagtca ttttagtgag tacatgcttt gtgaatcttt gtactttgta agctaataat 26580 agccactttt ggagttacag ggaatccgaa aactcctgtg ataacccatt ccgctcaaac 26640 tgtgtagttt taatatgacg aatcccaaaa gtagaaaaca acaactatat aatttatttt 26700 ttgtttgtag caacttaaaa gtgaaacaaa catgaggcat aacaaataaa attggttgta 26760 atcataaaga aaataaaggc ttttttgtct actactaacg tttaattgac cgtcactttg 26820 tacatccatt gcaaaagtat agcccgtttc tcaaattcac atatcattat atcgtaataa 26880 taatatcaaa cattctttgc aagaatatac cgttataatg aaaatttatc gttaacggct 26940 ttttgttgaa tgacgaaagt tgtccaaaaa atcacagcat ggcttgcact ttggtttttg 27000 ctaacgaatg tattgattga aaagactatc agaggtttct tacttaaaat ctaaaagaat 27060 aaatgaaaac cacatcgaaa ggaatgtaaa gtgtatatcg gtaaagatat gtacgctgta 27120 ggtagagggc tttgacacga aggcatattc gttgattaac ccatttagca gtataagggt 27180 cgttgaaacg aactagcata actttcggaa ctttttgtcg ctaaaaactt atttataaac 27240 ttattgcatt ttacgtagct gtttacatcg ttacaagtat cggtgaaaat agtgagtaag 27300 gctgagcgag tgacttctgc agtctatagc tggtgtcact tgtggattat taaattttct 27360 ttgaagaatt ttaaatattt acagccattt catcaacgtt gttcgttgtt ccgtggatgt 27420 gtacatgata ataatttaag taatataaat aaacaaaata taaatgacga acacttttat 27480 taaaatcggg tcttttttaa tttcccccct ccactactaa tctttgcctt gatgccctat 27540 aaagtaagat taaataaagg ttgtttattt ccataaagaa atatcatgag ttgacgagaa 27600 actaaatatc gtttatttga atcgaactac aatgaattca tgcctcagga tatctaaata 27660 ttggttagta tgcaatcctt aactctcgga atagtttata cggtgacgag caaacgtata 27720 actagttgat caaaattacc taattcaaat ttgacacttg gttgaattga attttcacat 27780 gatatttgaa agttgtttaa tcaataatta ttgttaacga cattaacgaa agcagaatta 27840 cgtagctata actcactaaa tctagaagta caatgatgtt gttatgtacg aaaggtgcta 27900 ttgaacacaa tatatatatg tcctacattg ctttcacatt tttacttgaa acaatcaaca 27960 ttagctggac ataaaatttt cttctcaaaa ggaaattaaa atttgaagta acttgaaaaa 28020 gtcaaagaag ctattataat tattactatg aaagataatc agcaagcagt tcagttacaa 28080 cagccaacaa caattggaca ctacttggcc gttcggttag cacaagctgg cgtaaagcat 28140 cattttgtgg ttcccggtga ctataatctt gggttacttg acaagctaca atacaacaat 28200 tatcttgaag aggtaaactg tgcaaatgag cttaactgtg cttttgctgc cgaaggatat 28260 gcacgtgcca acggtatcgc tgcgtgtgtt gttacctata gtgtaggagc tttcaccgcg 28320 tttgatggga ttggaggtgc atacgctgaa gaccttcctg taattttgat tagtggatct 28380 ccaaacacaa acgatatagg atcgtctcat ttattgcatc atactttggg aacccatgac 28440 tttagctatc aatatgagat ggccaagaaa attacttgtg ctgcggtatc tattcaaagg 28500 ccgactgagg cacctcgact aattgactat gcaattaaaa tggctttatt gaaaaagaag 28560 cctgtttaca ttgaagttcc tacgaatgtt gcttctcaac cttgtgcagc gccgggacca 28620 gccagcttga ttaccgagcc tgaaaccagc aatcaagaat atttgcaaat ggccgttgac 28680 attagcgcca aaatcgtaaa tggaaagcaa aagcccgtat tgttggccgg acctaaactt 28740 cgaagcttta aagctgagag cgcattcttg gagttggcga attcgttgaa ctgctctgtt 28800 gcagtcatgc caaacgccaa aagctttttc cctgaatctc atccaaatta tgcgggaatt 28860 tattggggac aggcaagcac actaggtgct gaatccatta tcaactggtc ggattgtatc 28920 atttgcgctg gaacaacatt tactgattat agctcaaatg gatggacttc gctaccaccg 28980 aaggccaatg tgttacatgt tgatgttgat cgtgtaactg tttctgatgc cgaatttggt 29040 ggagttttgt taagggattt ccttcatgaa ctagcaaaaa aggtgaaagc aaacaatgca 29100 agtgttgttg agtacaaacg tatacggcca gaatcacttg aaatacctat ggaaaacccc 29160 aaggctgcac tcaatcgaaa agagattatt cgccaggttc aaaacctcgt taatcaggaa 29220 acaactctat tcgttgatac tggtgattct tggtttggag gaatgagaat aactctgcca 29280 gaaaaagcga gatttgaaat agaaatgcaa tggggtcaca ttggatggtc cgtgccatct 29340 gcatttggat acgctatcgg agcacctaag cgcaatgtgg tagttttcgt tggagatgga 29400 tcatttcaag aaactgtaca agaagtgtcg caaatggttc gactaaattt accaatcatc 29460 atgtttttaa tcaacaacag aggatatact attgaagttg aaattcacga tggtccttat 29520 aaccgtatta aaaactggga ttatgcagca attgttgaag cattcaatgc tggagaaggt 29580 catgccaaag gattccgtgt tggaaatgga catgagctag ctgaagcaat tcgacaagct 29640 aaagaaaatt cccaagggcc aaccctcatt gagtgcaata ttgaccaaga cgactgtagt 29700 aaagaactaa tcaactgggg tcataacgtt ggagcagcta acggaaagcc acctgctaaa 29760 gagtaaaaga ttgcacaaac ctttccacct tttcagcaat tgcttatgca tttgcatact 29820 tttaatatag ataccttggt agaaatttga atacaacgaa atgattatat aaagagagaa 29880 aataatttat tctcttatct tattattttc caatgaaata agcttaattt cacttttatt 29940 cgtgattatt acagatgtgg gatgaactta aaaataagat acgaaataaa aaataaaaat 30000 aaaaaaggta ttgaaatgaa catattgtta agtgaaaacc taaacattta tttttttttt 30060 gcattgtttt aaaaaaaaag tggtccattt attgtttgct aatgtaaata aatttaatcc 30120 tttccgattg tagttcataa aaaatcatat accccaattg caaaatcctc atgatc 30176 //