ID SPAC16C9 standard; DNA; FUN; 14071 BP. XX AC Z54366; XX SV Z54366.1 XX DT 13-OCT-1995 (Rel. 45, Created) DT 18-OCT-1999 (Rel. 61, Last updated, Version 7) XX DE S.pombe chromosome I cosmid c16C9. XX KW methylthioadenosine phosphorylase; NAM7 protein homologue; KW nonsense-mediated mrna factor; NOT4 homologue; PHD finger protein; KW PNP/MTAP family 2 phosphorylase; KW regulator of nonsense transcript stability; KW serine/threonine protein kinase; transcriptional repressor. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-14071 RA Badcock K., Churcher C.M., Barrell B.G., Rajandream M.A., Walsh S.V.; RT ; RL Submitted (12-OCT-1995) to the EMBL/GenBank/DDBJ databases. RL Schizosaccharomyces pombe chromosome I sequencing project, Sanger Centre, RL Hinxton Hall, Hinxton, Cambridge CB10 1RQ E-mail: barrell@sanger.ac.uk XX DR GOA; Q09815; Q09815. DR GOA; Q09816; Q09816. DR GOA; Q09818; Q09818. DR GOA; Q09819; Q09819. DR GOA; Q09820; Q09820. DR SWISS-PROT; Q09815; KAB7_SCHPO. DR SWISS-PROT; Q09816; YAC2_SCHPO. DR SWISS-PROT; Q09817; YAC3_SCHPO. DR SWISS-PROT; Q09818; YAC4_SCHPO. DR SWISS-PROT; Q09819; YAC5_SCHPO. DR SWISS-PROT; Q09820; RNT1_SCHPO. DR SWISS-PROT; Q09839; YAC1_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe) CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPAC5H10.01c. CC SP (S. pombe), A (chromosome 1), c5H10 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c16C9 is overlapped by cosmid c4G8 at the 5' end and CC by cosmid c2G11 at the 3' end. XX FH Key Location/Qualifiers FH FT source 1..14071 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c16C9" FT /map="IL" FT misc_feature 1..110 FT /note="nominal overlap with c4G8 EM:Z56276" FT CDS join(complement(217..256),complement(103..179)) FT /db_xref="SWISS-PROT:Q09839" FT /label=SPAC16C9.01c SPAC4G8.14c FT /note="SPAC16C9.01c, len:>39, SIMILARITY:Saccharomyces FT cerevisiae, MK32_YEAST, P23060, MAK32 protein (46.7% FT identity in 30 aa overlap)" FT /partial FT /product="hypothetical protein" FT /gene="SPAC16C9.01c" FT /gene="SPAC4G8.14c" FT /protein_id="CAB43513.1" FT /translation="MDYPSKDVEFVTTGMFIIDEIEFDGGKKIKDIIGGAGSF" FT misc_feature complement(180..193) FT /note="ctaacgaatgcaag, splice branch and acceptor" FT misc_feature complement(211..216) FT /note="gtaaaa, splice donor sequence" FT CDS join(complement(1747..1848),complement(1137..1697), FT complement(777..1037)) FT /db_xref="GOA:Q09816" FT /db_xref="SWISS-PROT:Q09816" FT /label=SPAC16C9.02c FT /note="SPAC16C9.02c, len:306, SIMILARITY:Saccharomyces FT cerevisiae, YL17_YEAST, hypothetical 37.9 kd protein in FT ppr1-snf7 intergenic region., (337 aa), fasta scores: opt: FT 919, E():0, (48.5% identity in 305 aa)" FT /gene="SPAC16C9.02c" FT /product="putative Methylthioadenosine phosphorylase" FT /protein_id="CAA91190.1" FT /translation="MNKQAEPILLGVIGGSGFYDLPGFDIVESVNPITPWGYPASPISI FT ARTTSGFLIAFLARHGVGHIYTPTEVPSRANIAALKSLGVLAIVSFSAVGSLREDIPPE FT DFVLPTQIIDRTLCARPNTFFESGCVAHVSFGDPFDQDLYEILSSCGSNLKNGSKLHTK FT RKGDDLTVVCMEGPAFSTRAESNLYRSWGASIINMSVIPEAKLAREAEIAYQMVCMATD FT YDCWRMNEEPVTVETVMEHISNNKDNAKIFLLEAVKKLEAPLLQGFLGRNLRESVQNGI FT QTNHKHRNPDAIRRLQFLFPNLTIPH" FT misc_feature complement(1038..1051) FT /note="ttaacaaaaaatag, splice branch and acceptor" FT misc_feature complement(1131..1136) FT /note="gtaagt, splice donor sequence" FT misc_feature join(complement(1747..1821),complement(1137..1697)) FT /note="Match to PF00896 Mtap_PNP, phosphorylases family 2 FT Score 370.63" FT misc_feature complement(1698..1713) FT /note="ctaacgttttattcag, splice branch and acceptor" FT misc_feature complement(1741..1746) FT /note="gtatga, splice donor sequence" FT CDS 3172..4668 FT /db_xref="SWISS-PROT:Q09817" FT /label=SPAC16C9.03 FT /note="SPAC16C9.03, len:497, SIMILARITY:Saccharomyces FT cerevisiae, NMD3_YEAST, nonsense-mediated mrna decay FT protein 3, (518 aa), fasta scores: opt: 1735, E():0, (55.0% FT identity in 504 aa)" FT /gene="SPAC16C9.03" FT /product="putative nonsense-mediated mrna decay protein" FT /protein_id="CAA91191.1" FT /translation="MDMDSGSMGVAFQPSEPIASTILCCECGVPTPPNAAAMCMDCIKM FT TTDITSGIPRESTVNHCRECERYMQPPNNWMIAPLESRELMAICLKKLRGLNQVRLVDA FT NFIWTEPHSRRIKVKLTVQKEAFTNTILQQSFQVEFYVNNTQCPDCARTYTPHIWKAVC FT QVRQKVLHKRTFLYLEQIILKHKAHMNTVNIKETKDGIDFYFGQRAHAIKMVEFLSAVV FT PIRYKGSEELISEDFKSNTANYKFTYSIEIVPICKDDLVCLPKTVAKAHGNIAQLVVCT FT KVGPTIRFLDPLTLQTCDMLPSIYWRTPFPALADIPELTEFIVADVDLLGPTNGKYALA FT DVELIKSSDGSTHLTRTHLGGILNAGNTVLAYHLAVTNFNNEVYDTLREDSIPEVVIVK FT KTYPQTKKKNRNWRLKTIGMQKAEDVKKQDIERQERDYELFLQNLEEDPELRQGVNLYK FT APVKAIAVADTDMDEEDEVDEDIPQISVDELLDDVEAMHI" FT CDS join(complement(6636..6688),complement(6406..6585), FT complement(5081..6317)) FT /db_xref="GOA:Q09818" FT /db_xref="SWISS-PROT:Q09818" FT /label=SPAC16C9.04c FT /note="SPAC16C9.04c, len:488, SIMILARITY:Mus musculus, FT AAD00181, potential transcriptional repressor not4hp., (575 FT aa), fasta scores: opt: 891, E():0, (44.5% identity in 328 FT aa)" FT /gene="SPAC16C9.04c" FT /product="putative transcriptional repressor" FT /protein_id="CAA91192.1" FT /translation="MLKTQEIYSSEDEDDMCCPLCMEEIDISDKNFKPCQCGYRVCRFC FT WHHIKEDLNGRCPACRRLYTEENVQWRPVTAEEWKMDLHRKNERKKREKERKEVELSNR FT KHLANIRVVQKNLAYVNGLSPKVANEENINVLKGPEYFGQYGKIIKIAINKKAAANSAN FT GHVGVYITYQRKEDAARAIAAIDGSVSDGRHLRASYGTTKYCTSYLRNQQCPNPSCMYL FT HEPGDEVDSYTKEDLASLQHTRPLSTKPNVVNGATHSPSPSLPFKTPLLPVTKTPLEEA FT NSSPAAQNQHITTVDHVHPQVSMTPSLSTNNTATSVPAPYSSAASVNVVPGHATTILHH FT EESSALPPTAAWAKLSPSVLQERLRAAVNQQPLDALKSSSTQTSIPKIQKLKAAKLPSE FT EENTTKWLNKAINDLVSSLSKINFSTEGTEFDKKQIEMIQNLPPLFVFNARSVIDKEVV FT PEQEKSAENQPPTSLGINNGNPVMPPPGFQS" FT misc_feature complement(5963..6196) FT /note="Match to PF00076 rrm, RNA recognition motif. (a.k.a. FT RRM, RBD, or RNP domain) Score 27.22" FT misc_feature complement(6318..6330) FT /note="ctaatgtttttag, splice branch and acceptor" FT misc_feature complement(6400..6405) FT /note="gtatgt, splice donor sequence" FT misc_feature complement(6586..6601) FT /note="ctgacaattgcaacag, splice branch and acceptor" FT misc_feature complement(6630..6635) FT /note="gtatgt, splice donor sequence" FT CDS 7638..8852 FT /db_xref="GOA:Q09819" FT /db_xref="SWISS-PROT:Q09819" FT /label=SPAC16C9.05 FT /note="SPAC16C9.05, len:403" FT /gene="SPAC16C9.05" FT /product="PHD finger protein" FT /protein_id="CAA91193.1" FT /translation="MASSINNSSQPTVPSISNNSHGDSFVNEGPPSNFKNNSLTSSTHS FT STDHVNVLPISQDKEMDISSPVKKQKASYSNKSPNKAPIQKSRGSSLKSHLETESQQTP FT VKRRRRKATIRNVDYCSACGGRGLFICCEGCPCSFHLSCLEPPLTPENIPEGSWFCVTC FT SIKSHHPPKHPLSIWSQLYDWIDSQNPSQYRLPDDLVHYFHGISRGDTGAYKETEGEMD FT TDEFSALPTGSSITNLAYCGYCSKPSMGACWVYGCQLCDTFYHKNCKEHAKKCSHDSIG FT KKGMRVPKNAVVIRTPLVLDTTSNTLNPKVMISGWQFLMGEFPSDELLYFPRLPVSCLY FT KVSEDGLIKDFLYAIGIEAKKFNNERKKRELEVIPPDVKSALLPARTHPNLPIALRTLF FT NKART" FT misc_feature 7986..8135 FT /note="Match to PF00628 PHD, PHD-finger Score 75.39" FT CDS complement(9398..12175) FT /db_xref="GOA:Q09820" FT /db_xref="SWISS-PROT:Q09820" FT /label=SPAC16C9.06c FT /note="SPAC16C9.06c, len:934, SIMILARITY:Homo sapiens, FT O43343, pnorf1, (1118 aa), fasta scores: opt: 3436, E():0, FT (57.8% identity in 872 aa)" FT /gene="SPAC16C9.06c" FT /product="putative regulator of nonsense transcript FT stability" FT /protein_id="CAA91194.2" FT /translation="MSLGLQPNNDISSLVSSKNMTSENGLEHQFEELLVEKQYSEEHCA FT YCHIKNPNSILKCLHCNKWFCNVRGKSGASHIISHLVRARHKQVALHSHSSLSDTVLEC FT YNCGTRNVFLLGFIPAKAKTVVVLLCRQPCARASIAKDMNWDLTQWQPIISDRQFLPWL FT ITPPSEEEQKLAIPITSQQMVRLEELWRKDPNANLEDLDKPIEDDSLPSVELRYKDAHA FT YQAVLSPLIQAEADYDKRLKESQTQKDVVVRWDQAINKRYTAWFLLPKLESGEIRLAIG FT DEMKLTYEGELRAPWSSTGYVIKIPNNVSDEVGLELKRSDKVPIECTHNFSVDYVWKST FT SFDRMQTALRLFATDGSRLSSFLYHKLLGHDIPPSFLKPKLPSDLSVPNLPKLNASQSE FT AVRAVLSKPLSLIQGPPGTGKTVTSASVVYHLATMQSRKRKSHSPVLVCAPSNVAVDQL FT AEKIHRTGLRVVRVAAKSREDIESSVSFLSLHEQIKNYKFNPELQRLLKLRSENNELSI FT QDEKKLRILVAAAEKELLRAAHVICCTCVGAGDRRISKYKFRSVLIDEATQASEPECMI FT PLVLGAKQVVLVGDHQQLGPVVMNKKVALASLSQSLFERLIILGNSPFRLVVQYRMHPC FT LSEFPSNTFYEGTLQNGVTTSERIARHVDFPWIQPDSPLMFYANFGQEELSASGTSFLN FT RTEASTCEKIVTTFLRSNVLPEQIGIVTPYDGQRSYIVQYMQNNGSMQKDLYKAVEVAS FT VDAFQGREKDFIILSCVRSSEHQGIGFVNDPRRLNVALTRAKYGVIVLGNPKVLAKHAL FT WYHFVLHCKEKGYLVEGTLNSLQKFSLTLTPPQKPQKFKRDLNVQRSLSPIQNAGSAML FT PSFSNLPNLYSSSYLEEWNVFAQYKRRESNATDFEDFRSQVGDDESKFDEPTRF" FT misc_feature complement(10913..10936) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 13084..14070 FT /db_xref="GOA:Q09815" FT /db_xref="SWISS-PROT:Q09815" FT /label=SPAC16C9.07 SPAC2G11.01 FT /note="SPAC16C9.07, len:>328" FT /partial FT /product="putative serine/threonine protein kinase" FT /gene="SPAC16C9.07" FT /gene="SPAC2G11.01" FT /protein_id="CAA91195.1" FT /translation="MVGLISTSETLPKQESKSSSAPVSNFLSPNNLTEQTCSPLRAHST FT FKEPVFLLSQRQYSHNSKILTELINSVKRPNKPDQNEEKSAVGIEEKSFKDEHLAQKKG FT LHHFADLKEIFLNKNLSTLDGLQDASLHDNIQSGKLDNPVISQNRRIVLEKLANPNSSK FT EYETIPTVENRHPLNKLSKTKTLAYEETINQLDETPGGTNYPMNKKKTLSSETNKYEYP FT QQSKFHECSQFASPRSSIVNGPRTLGKNSKRADDTARMASRMKPSNFNNNIQSSSYGHA FT SQSTKLTSQRDNDHQKDLNFSPYKSIPLNNRPYSPMSEIVGFSGSTTP" FT misc_feature 13963..14071 FT /note="nominal overlap with cosmid c2G11 EM:Z54354" XX SQ Sequence 14071 BP; 4537 A; 2552 C; 2494 G; 4488 T; 0 other; ttctaaggga gaggatttca accttcgata aacagatatg cttcaccaat gaagttcgca 60 aatcgctccg cttaaaattt taaaaagaat tagacactta ccaaaagatc ctgcacctcc 120 aataatatct ttaatcttct ttccgccgtc gaattcaatt tcatctataa taaacatgcc 180 ttgcattcgt tagcacttat atgtgaaagt ttttaccagt tgtgacgaat tccacatctt 240 tcgaaggata atccattttg ttaatcccaa aaaattactg taagttgttt ttttcttaat 300 tataagaaca tatattgctt taatgttggt gcattaaaag tcagagttag cgaacatctg 360 cagataatct acgtaattat caataaacat cctgcactct gtatagtaat ttaaaggtaa 420 catggcgaat aattaaataa aatatttcat atttatgaag gaagtgttga atcatgctga 480 aaattaagta tccgtaaaaa atgtactttt gcatttgctt acttttgtat gagatgaatg 540 ggcatactac tacataccat atatcaagca cacatgtcat acttagaaca ttgtattttc 600 ctaacgatat ataggaagta ctcatcattc tcaaaaagga attatcactt tccaatataa 660 aattaactaa tctaagtgtt agcaatgcaa cagtcctgac cagtcaatta gcaagcaata 720 tagctaagtc tactctttta taaaatttca aatgttactt cccaaagctt tgctctttag 780 tgcggaatgg taagattggg aaaaagaaat tgaagtcgtc taattgcatc tgggttacga 840 tgcttgtgat ttgtttgaat cccattttga acactttctc gcaagttcct tcccaaaaat 900 ccttgcaaaa gtggagcttc taactttttg acggcttcca gtaaaaagat ttttgcatta 960 tctttattgt tactgatatg ttccatcacg gtttcaacag taacaggctc ctcattcatg 1020 cgccagcaat cataatccta ttttttgtta aaattccttc ctaataataa gttcaaagta 1080 cttgtctaaa aagcatggct ttgatttgag aggtacattg aatgttaaaa acttactgta 1140 gccatgcaaa ccatttggta ggcaatctca gcttcgcgag ctagtttggc ttcgggaatg 1200 actgacatgt tgataatact ggctccccag cttctgtata aattgctttc tgcacgcgta 1260 ctaaatgcag gaccctccat acacacgaca gtaagatcat ctcctttgcg tttggtatgt 1320 aatttagaac cattttttaa gttggagccg catgaactta aaatttcata caagtcttga 1380 tcaaatggat caccaaacga aacatgagct acacaaccag attcaaaaaa agtgtttgga 1440 cgagcacaaa gggtgcgatc aataatctgt gtaggcagaa caaaatcctc cggtggaata 1500 tcctccctca aagatccaac agcgctgaac gaaacaattg ccaaaacacc taaacttttt 1560 aaagctgcga tatttgctcg agatggaact tctgtaggtg tataaatgtg accgacacca 1620 tgtctagcca aaaatgcaat caaaaaacca gaggttgtgc gggcaatgga aattggagaa 1680 gctggataac cccatggctg aataaaacgt tagcaaatcc caacttccag ttaatcttca 1740 tcataccgta ataggattga cactttcgac aatatcaaat cctgggaggt cataaaaacc 1800 gctacctcca attactccaa gaagaattgg ctcagcttgt ttgttcatac ttttttcaat 1860 gagggaatgg ataaagtgct gaaaatgggt agcaaaacta cacctttagg gcagatgaaa 1920 atttttgcga gttgtcaatg tcaaggaata aaagattttc aagatattta aaagaaagtt 1980 atttgttatt tatacatttt aattattttt tttttttttt ttttttgttg taaaaaaaat 2040 tattatttat ttagctagtc attacaaaat aacgattctt tttttgatga agtaaatttg 2100 ttttcttctt tttatccaac tgctatgttt tttacatttt ttctaatact caggagtgct 2160 ctagtggttt ataaatatag gtactttaat tgaatacgaa aatataccga ttaacagtaa 2220 tattcaaaac ttctgttttt gtatatcatt gagcttgtgt taactagagt acatatttta 2280 caaatgttaa atttatgttt attttccaaa cctgttgtct aaaattttaa ctataatgag 2340 aagttttcga agtatatgat acttgctttt ttaataaaaa acattttttc caattatagc 2400 agaataataa atgccttggc ttactttcta gactattctc aataaaatga ctacttaatt 2460 tagttaaaca tatacaaaaa catccgatat ttgttttcct aaatgaaata caaaagtttt 2520 taagatacaa ccatatgata caacaatgac aaacgtggga ttacttctaa tattataaaa 2580 tcgttttgat aattaaaatt gttttggcca tggcttcagc aatatatact atgcatagta 2640 tgatacataa ctttcactgt tcgatatttt ctataatctg atgctatgat tatttttaga 2700 aattagcgta agactcataa gttgctttgc tgtgtaaact agctataaaa ctaagaaact 2760 cacgtttcct tggatcagtt gaaagttcaa tcttaatata gttataatac tatttagtat 2820 tttccgatat ttttgtagct agcttcatta tttgtggtaa gcatactagc atcattttca 2880 gtagatctaa gtcacgagga acactcggca tagtcttttg gatttttaaa agcattttac 2940 cgattcctca tagctctact aataactatg tgccccttat aaaataaggt gctttagcag 3000 aaaatgaaaa aatctcgtta aagatttact gcgaatttaa ttacagtagg gaaaaaaatt 3060 actttcctta agactgtaca tttgaagtta tcttcttcca attcagtgcc aacaattgtt 3120 aattgaaact cccatatatt ggccttgcat taagggtttt cagtaaaaat aatggatatg 3180 gacagtggaa gtatgggggt tgcttttcaa ccctcagagc ctattgcttc aacaatcttg 3240 tgttgtgaat gtggagttcc aacacctcct aatgcggctg ctatgtgtat ggattgtata 3300 aaaatgacaa cggacatcac tagtggtatt ccacgggaaa gcacagttaa ccattgtcgt 3360 gaatgtgaac gatacatgca accacctaat aactggatga ttgcaccatt ggaatctaga 3420 gaattgatgg ctatttgctt aaaaaagctt cgaggcttga atcaagtacg ccttgtagat 3480 gccaatttta tctggaccga accacattcc cgacgaatta aagtcaaatt aacggtacag 3540 aaagaagcct ttacaaacac catcttgcag caaagttttc aagttgaatt ctatgttaat 3600 aatacacaat gtcctgattg tgctagaact tacactccac atatatggaa agcagtttgt 3660 caggttcgtc aaaaagtgtt acataagaga acgtttttgt atttggagca gattatttta 3720 aagcataaag ctcacatgaa cactgtaaat attaaagaaa ctaaagacgg aattgatttt 3780 tactttggcc agagagcaca tgcgattaaa atggttgaat ttttaagtgc tgttgttcct 3840 attcgctaca agggcagtga agagctcatt agcgaagatt ttaaatccaa taccgcaaat 3900 tataaattta cttattcaat tgaaattgtt cctatctgca aagacgatct tgtatgttta 3960 ccaaaaacgg tagcaaaagc ccatgggaac attgctcaac ttgtggtatg tacaaaagtc 4020 ggacctacga tccgctttct tgatccgctt actttacaaa cctgtgatat gcttccctca 4080 atttattggc gtaccccgtt ccctgcactt gcagatattc ccgaacttac tgagttcatt 4140 gttgccgatg tcgatttatt aggcccaaca aatggaaagt atgccctcgc cgatgtggaa 4200 ttgattaaat catccgatgg gtcaacgcac ttaacacgca cccatcttgg tggtattcta 4260 aatgcgggca ataccgtcct tgcgtatcat ttagctgtta ccaattttaa caatgaagta 4320 tatgatactc ttcgtgaaga ttctattccg gaagttgtaa ttgttaagaa aacttatcct 4380 caaacgaaaa agaagaatcg gaattggcgt ctcaaaacta tcggaatgca aaaagccgag 4440 gatgtcaaga aacaagacat tgaacgtcaa gaacgtgatt atgagttatt cttgcagaac 4500 ttggaggagg atcctgagct tcgccaaggc gtcaacttat acaaagcacc agttaaggct 4560 attgccgttg cagatactga tatggatgag gaggatgagg ttgatgaaga cattcctcaa 4620 ataagcgtcg atgagttgtt agatgacgtt gaggcaatgc atatttaaaa atgctttagg 4680 ttaccaaacc ttttttagtt tttattttgt tcttgaaccg ttttggattg ggttatcaga 4740 tgggattggt tattcacgta ctttaatttt agaagtttta tttaaacaaa gctttcttcc 4800 acattttttt tagaaattag tgattcgttt taatgagttg aggacaaatc gactttaaat 4860 ggcttttaaa agtaaataaa actttcgtaa gatgatatga cttactaaga taactagatc 4920 agtatgtgct atgtatgagg tggtaaaatt ataagtaaag aataggcttt ttttaccatt 4980 tttagtcaat ctactatatg aggaacccat agagaattta tctttaaaat tttttaataa 5040 tatttatgta aatactacaa aacttaaatg aaaaagaaga ctaactttgg aaaccaggag 5100 gaggcattac agggttgccg ttattaattc ctagagaagt aggaggttga ttctcggcgc 5160 ttttttcctg ttcagggaca acctccttgt caataacaga acgcgcgttg aatacaaaca 5220 acggaggaag attctgaatc atttcgattt gctttttatc aaattcagtt ccttccgtgc 5280 taaaattgat tttactcaac gatgaaacca agtcattaat tgctttgtta agccactttg 5340 tagtgttttc ttcttccgag ggtaatttcg cagctttcag tttttggatt ttaggtattg 5400 aagtctgggt tgatgaggat ttcagtgcat ctaaaggttg ctgattaaca gcggcacgta 5460 atcgttcttg taatacgctt ggagataatt ttgcccaagc agcagttggt ggaagagcag 5520 aactctcttc gtgatgaaga atagttgttg catgtccagg aacgacgttt acagaagcag 5580 cagaagaata aggggcagga acgctggtag cagtgttatt agtggataag gaaggtgtca 5640 ttgacacttg tggatgaaca tgatcaactg ttgtaatatg ctgattttgt gcagctggac 5700 tactattagc ctcttctaac ggtgttttcg taacaggaag tagaggtgtt ttgaatggaa 5760 gagaaggaga aggagaatga gtagcaccat ttaccacatt aggtttagtg gaaagaggac 5820 gggtatgttg aagagatgcc aagtcttctt tagtataact atccacctcg tcaccgggtt 5880 catgtaaata catgcaagaa ggattggggc attgctgatt ccgtaaataa gaagtgcaat 5940 atttagtggt accataagat gcgcgaagat gtcgcccatc acttacgctg ccatcaattg 6000 cagcaatcgc tcgtgcagca tcttcttttc tttggtatgt aatataaact ccaacatgac 6060 catttgcaga atttgcagca gccttcttat ttattgcaat tttaataatc tttccgtatt 6120 gaccaaagta ttcaggtccc ttcagaacgt tgatattctc ctcatttgca actttgggag 6180 aaaggccgtt tacataggca aggttctttt gtacaacacg aatatttgca agatgcttcc 6240 tgtttgaaag ctcgacttcc ttcctctctt tctcgcgttt cttcctctcg ttttttcgat 6300 gtaagtccat cttccatcta aaaacattag cgacatgttt aaaaataaaa gtgaatttaa 6360 acaagattat gcttaaacaa gaattctata atctgaatta catactcctc tgccgtgaca 6420 ggccgccatt gaacattttc ttcagtgtac agacggcgac atgcaggaca acggccattt 6480 agatcttctt tgatatggtg ccagcaaaat ctacaaactc tgtatccgca ttggcatggt 6540 ttgaagtttt tatcagagat atcaatttct tccatacata gaggactgtt gcaattgtca 6600 gttaattttg atactaatcg gctagtaaaa cataccaaca catgtcatcc tcatcttctg 6660 aagaatatat ctcttgcgtt tttaacattt tgtgtgaaat atgtcaaatc tccgtcacag 6720 tgctctccaa atcgatactg tttaaggtcg ctcgttatac aatacagagg aagtcttcaa 6780 atatcttaaa tcaaatcttt gattttaatt taatttagtt aattccctta atattcatta 6840 gacttcaaac aaatattttt taaagggcaa accgagttgt ggttggttat aagtttactt 6900 acaacttagt gtaaaagaag gaggcaatga ctaggtgaga ggttggattt gaacagtata 6960 taccacacga aaaatagcaa ttaatagaca tgaattaaga aatttgagaa aattcttatt 7020 ccaaaggttt ttggaattgt gtttgaacaa caaaaagtac ccttaaaagt ttcaccgtct 7080 ataatttcat cttgataatt aattgcagta aacgtttgta aacgaatgta ttatatatac 7140 aactttttca cgttgtggtc aaattcttta gttatttcat cttctaagta attagtgaat 7200 atattgaatt gacgaaaaaa cgatgaacaa cataataaga ggcataaagt gcttctctac 7260 ttaatttacg ctccatgttc catcaaatgg ataatagttt ttaacaaaat gttcaaatat 7320 tttacatata gaagggaatt tattcttatg ataatcattt atactaaatg ctcctctcga 7380 aaatcagata tctttaagta gttttctaag tctaattgca acgacgtttg gcgttcaaag 7440 acttgttgta acttagcatc ttcataacag cgttgcttca ctataatata cttacaacct 7500 cgaccattgt tcttttttac gataaccatt aattttacct ttaatattcc ttaaaacatt 7560 aaggatagta ttgatatttc taagtgctaa ccgtcgcgta ttacatgttg ctttgctcat 7620 agcatgggaa gtatctaatg gcatcctcta taaacaattc atctcaacct acagtacctt 7680 caatttctaa taatagtcat ggcgactctt tcgtaaatga aggtccccct tctaatttta 7740 aaaataattc tttaacatca tcaactcact cttcaactga ccatgtaaat gtcttgccaa 7800 ttagccaaga caaagagatg gatataagtt ctccagtgaa aaaacaaaaa gctagttatt 7860 cgaataaatc tccaaataaa gcacctattc aaaaaagccg gggtagttcc ctaaaaagtc 7920 atctcgaaac cgaatctcaa caaactcctg taaagcgacg gagacgaaaa gcgactatac 7980 gcaacgtcga ctattgtagt gcatgcggag gaagaggtct ttttatttgt tgcgagggat 8040 gtccttgcag tttccatctt tcatgcttgg aacctccctt gactcctgaa aatattccag 8100 aaggatcttg gttttgtgtg acttgctcaa tcaaatcgca tcaccctcct aagcaccctc 8160 ttagtatatg gtcccagctt tacgattgga ttgattctca gaatccctcg cagtaccgat 8220 tgcccgacga ccttgtgcat tatttccatg gaatatctcg tggggataca ggtgcttata 8280 aggaaactga aggagaaatg gatactgacg agttttctgc tttgccgact ggctcctcta 8340 tcactaatct agcttactgt ggttattgct ctaagccatc aatgggtgct tgttgggtct 8400 atggttgcca gctgtgtgac accttctatc ataaaaattg taaagagcat gctaaaaaat 8460 gctctcatga ctccattgga aaaaaaggta tgagagtacc aaaaaacgcc gtggtgataa 8520 ggacgccctt ggtgttggat acaacttcta atactcttaa tcctaaagtc atgatttcag 8580 gatggcaatt tcttatggga gagtttccaa gtgatgaact tctctatttc ccaagattac 8640 ccgtgagttg tctctacaaa gtttcagaag acggtctcat caaagatttt ttgtacgcga 8700 ttggcataga agctaaaaag tttaataatg aaaggaaaaa acgagagtta gaggttattc 8760 ctccagacgt aaaaagcgca ctacttcctg cgagaacgca cccaaaccta cctattgcac 8820 tacgcacttt attcaataag gcacgcactt gaatttttac gatattttta cattttgtat 8880 aaaatcagac tacgttaatc taatctgtcg tgttcaaatc gtcagaaaag gttgttttct 8940 gttatttttt tgctaatgtt gtatttataa aacctcttag aactggctat ctgttgtaat 9000 tggcttattt tacattactt ttctccatta aggcttttaa aaaattttcg ttatgcaatt 9060 aatcattgca aatccttcct aatagggcaa aagttctatt ttatactaac aacttctcaa 9120 tacttaaatt ttatacgcgt attgtaccgt gtgagtatat ataagtatat ataagtatat 9180 ataagtatat atgagtaaga tgcatttact agacaaagag gaataaaata aaagaaagtg 9240 ataaggaaag gttctattac taaagtctat ttaacagcca tatcaatggt ttaaaacgct 9300 tacagaccaa acggtccata aaacttgaac accaaaaata tcaacaaata aaagatatgt 9360 tggcattcgt aattacaagt aagcaaatac ttattaacta gaacctagta ggttcgtcga 9420 acttgctttc atcatcacca acctgacttc taaagtcttc aaagtcggta gcgttgcttt 9480 ctcttcgttt gtattgagca aagacattcc attcttcaag atacgaggaa gagtataagt 9540 tcggaagatt agaaaacgaa ggtaacatgg cagaaccggc attctgtata ggagatagtg 9600 atctttgtac attgaggtct cttttaaatt tttgaggttt ctgaggagga gtaagggtta 9660 aggaaaactt ttgtaagctg ttcaaagtgc cttcaactaa atatcctttt tccttgcaat 9720 ggaggacaaa atgataccat aaagcatgtt tagcaaggac ttttggatta ccgagaacaa 9780 ttacaccata ctttgctcga gtcaatgcaa cgttcaacct tcttggatcg ttaacaaaac 9840 caataccttg gtgttcacta gaacgtacac acgacaaaat aatgaagtcc ttttctcttc 9900 cttggaacgc atccaccgat gctacttcaa cagctttata aagatccttc tgcattgatc 9960 cgttattttg catgtactga acaatatagg aacgctgacc atcatatgga gtaacaatac 10020 caatttgctc aggaagcacg ttgcttctta aaaatgtggt aacaattttt tcacacgttg 10080 aggcttccgt tctgtttaaa aatgatgtac cgctagccga cagctcttcc tgaccgaaat 10140 ttgcataaaa cattaatggc gaatcaggtt gtatccatgg aaaatcaaca tgtctagcaa 10200 tacgctcaga agtagtgaca ccattttgaa gagtaccttc ataaaaagtg ttcgatggaa 10260 attctgaaag acagggatgc atacgatatt gcacaactaa tctgaaagga gagtttccta 10320 atataatcag tcgctcaaaa agtgattggg aaaggctagc taatgcaacc tttttattca 10380 taacaaccgg tcccagttgt tggtgatcac caacaagtac tacttgtttg gcgcctaaaa 10440 ctaaaggaat catgcattca ggttctgaag cctgtgtagc ttcgtcaata agtactgaac 10500 gaaatttgta cttggaaatc cttctatcac cagcaccaac acaagtacaa caaatgacat 10560 gagccgcacg taatagttct ttttcggcag cagcaaccaa aatacgcagt tttttttcat 10620 cctgaataga taattcgtta ttttcacttc gtagcttcaa taaacgttgt aactctggat 10680 taaacttata gtttttaatt tgctcatgaa gagataaaaa ggaaaccgat gattctatgt 10740 cttctctaga ctttgcggca actcgaacga cacgaagtcc tgtacgatgt attttttcag 10800 caagttggtc aacagcaaca ttcgaaggtg cacaaactaa tacgggagaa tgggatttac 10860 gcttgcgtga ttgcatcgtg gccaggtgat agactacaga tgctgaggtg acagtttttc 10920 cagtacctgg cggcccttga attaacgaga gtggcttact taatactgca cgaacagctt 10980 cgctctgact agcattcaat tttggcagat taggcaccga taaatcagac ggtaattttg 11040 gtttcaggaa ggaaggaggg atatcgtgtc ctagcaattt atgatacaaa aagcttgaaa 11100 gacgtgatcc gtctgtagca aataacctca aagcagtctg cattcgatca aatgaagtag 11160 atttccaaac ataatcgacg gaaaaattat gagtacattc gataggtact ttatctgaac 11220 gcttcagttc taaacctacc tcatctgaaa cgttgttagg aattttaata acatatcctg 11280 tggagctcca gggtgctctt agttctcctt catatgtaag cttcatttca tctcctatgg 11340 ccaaccgaat ttcaccagat tcaagtttgg gaaggagaaa ccaagcagta tatcgtttat 11400 tgatagcttg atcccaccga accacaacat ctttttgagt ctgcgattct ttgagtcgtt 11460 tatcatagtc agcctccgct tgaatgagcg gagaaagaac tgcttgatac gcgtgagcat 11520 ctttatatcg aagttctact gaaggtaatg aatcatcctc aatgggctta tccaagtctt 11580 cgaggttagc attagggtct ttacgccaaa gttcttcaag cctaaccatt tgctgtgaag 11640 tgattgggat tgcaagcttt tgttcctctt cggatggagg agttatcaac catggaagaa 11700 actgacgatc tgaaataatg ggttgccatt gagtcaagtc ccagttcata tccttagcta 11760 tgctagctct agcacaaggt tgtcggcata ataaaacaac cactgtctta gcttttgctg 11820 gtataaatcc taatagaaac acatttctcg ttccacaatt ataacactca agtactgtgt 11880 ctgaaagaga agaatggcta tgtaaagcaa cctgcttatg tcgagcacga actaggtgac 11940 taatgatatg cgaagctcca gatttccctc ttacattaca aaaccattta ttacaatgca 12000 aacatttcaa tatagaattt ggattcttta tgtggcaata ggcacagtgt tcttcagaat 12060 attgtttttc gactaataat tcttcaaatt gatgctctag tccattttca gaagtcatat 12120 tttttgaact aactaaagat gaaatatcat tattaggttg tagccctaaa gacatggaaa 12180 gacaacttga tatgttatta agccgtcaat ttgcaaagtg taaataattg taacacattt 12240 ttagaaagaa aggttagtca tttagtgagg tttaatgagt taaaatgtgc tgctaggaag 12300 ctccctaaaa cgtaaacaaa aaacgccgtt aatgggaaaa actaacaata gcaagactca 12360 tttacttgta agatattata tctattcagg gtagataaat tttgtcagtt tcgagatgat 12420 catttacgtt cttgaaacag ctggtcgtac tatagattac taaataaggt agagcactgt 12480 agtattgtga cacaaatcgg tgctcactat tggaattaaa caaaattata taaacggttg 12540 ctgagaccat gtaaacaatc atattgaaga ctattaattt tttgactaac agttgtcgaa 12600 aagtaataaa cagatatttt taacttaata tcggactcta tacaaattta ttaacatgag 12660 agttgtatct actcgctctg gaagttagca taccaagtgt accgttaccc attttgaact 12720 tttcaaggag tgtgttactt ccacctatac aacaactgcc cgtgtgaaac tatccaaatt 12780 gaaataattt taagaatttc aggcctctta attgtctgaa cttcttggag tttatgtggt 12840 gcttagcggc aaactcttca tgaactgaag aggcttcaaa gaggggactt cgaatgctgc 12900 gtttaacaag ttgatttact tgtaagtatt tgttctccaa atccgggttt aattccttct 12960 tttaaaatta tttttcgttt cacaacattt catttttccc caccctggtt taagcagcta 13020 gtgcctttaa ttatttgatt tttctacttt ctttacgtta atcaacttcg acaacaatta 13080 taaatggtgg ggttaataag tacaagcgaa acgctgccta aacaggagag taaaagttcc 13140 tcagccccag tgtctaattt cctttctcct aataatctga ctgaacagac atgcagtcct 13200 ctaagagctc attctacttt taaagagccc gtatttctgt tatcgcaacg ccaatattca 13260 cacaatagca aaatacttac agaattaata aatagtgtga aaaggcctaa caagcccgat 13320 caaaatgaag aaaaatcggc tgttggaata gaagagaagt cctttaaaga tgaacacttg 13380 gcacagaaaa aaggattgca tcattttgca gatctaaaag aaatctttct gaataaaaat 13440 ttgagtactt tggatggttt acaagatgca tcgcttcatg acaacataca gagtggaaaa 13500 ttagacaacc cagttatatc tcaaaaccgt cgcattgtac tagaaaagct tgctaatccc 13560 aattccagca aagaatatga aaccatccct acagtcgaaa accgacatcc actcaacaaa 13620 ttaagcaaga caaaaacttt agcttacgaa gaaactatta atcagctaga tgaaacccca 13680 ggaggaacga attatcccat gaacaaaaaa aaaacattat cttctgaaac taacaaatat 13740 gaatatccac aacaatcgaa attccatgaa tgttctcaat ttgcttcacc acggtcttct 13800 atagtaaatg gacccagaac cctcggaaaa aattctaaaa gagctgatga tactgcaaga 13860 atggcttcgc gaatgaaacc atccaatttt aataataata ttcagagcag ttcatacgga 13920 catgcatcac aatctacgaa attaacgtcc caaagagaca atgatcatca aaaagatctc 13980 aactttagtc catataaaag tattccttta aataataggc cttattctcc tatgtcagaa 14040 attgttggtt tttctggttc tacaactcct c 14071 //