ID SPAC16 standard; DNA; FUN; 11922 BP. XX AC AL121745; XX SV AL121745.2 XX DT 04-OCT-1999 (Rel. 61, Created) DT 07-OCT-1999 (Rel. 61, Last updated, Version 2) XX DE S.pombe chromosome I cosmid c16. XX KW conserved hypothetical; dihydroorotase; pre-mRNA splicing factor; KW ras family; rho2; RNA recognition motif; RNP domain; RRM; srp2; KW zinc finger. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-11922 RA Davis P., Churcher C.M., McDougall R.C., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (04-OCT-1999) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; P78814; P78814. DR GOA; Q10133; Q10133. DR GOA; Q9UTH9; Q9UTH9. DR GOA; Q9UTI0; Q9UTI0. DR SPTREMBL; Q9UTH8; Q9UTH8. DR SPTREMBL; Q9UTH9; Q9UTH9. DR SWISS-PROT; P78814; SRP2_SCHPO. DR SWISS-PROT; Q10133; RHO2_SCHPO. DR SWISS-PROT; Q9UTI0; PYRC_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c16 is overlapped at the 3' end by cosmid c9E9. XX FH Key Location/Qualifiers FH FT source 1..11922 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c16" FT /map="IR" FT CDS join(85..110,195..273,390..395,449..487,600..640,709..727, FT 776..868,913..1047,1095..1259) FT /db_xref="GOA:Q10133" FT /db_xref="SWISS-PROT:Q10133" FT /label=rho2 FT /note="SPAC16.01, len:200" FT /gene="rho2" FT /gene="SPAC16.01" FT /product="rho2 protein" FT /protein_id="CAB57399.1" FT /translation="MLQSQPIRRKLVVVGDGACGKTSLLSVFTLGYFPTEYVPTVFENY FT VSDCRVDGKSVQLALWDTAGQEEYERLRPMSYAKAHIILVGFAIDSPDSLENVSTKWIE FT EINTLCPNVPFILVGMKADLRSDPVAIEEMRRRNQNFVKSQQAELVAQRIGARKYMECS FT SLTGDGVDDVFEAATRAALTVRDSENDKSSTKCCIIS" FT misc_feature 111..116 FT /note="gtacga, splice donor sequence" FT intron 111..194 FT /note="confirmed intron" FT misc_feature 181..194 FT /note="ttaatatttttaag, splice branch and acceptor" FT misc_feature 274..279 FT /note="gtaagt, splice donor sequence" FT misc_feature 372..389 FT /note="ctaacttactggcgatag, splice branch and acceptor" FT misc_feature 396..401 FT /note="gtaatg, splice donor sequence" FT misc_feature 430..448 FT /note="ttaataacagttactatag, splice branch and acceptor" FT misc_feature join(452..487,600..640,709..727,776..868) FT /note="Match to PF00071 ras, Ras family Score 74.82" FT misc_feature 488..493 FT /note="gtatgt, splice donor sequence" FT intron 488..599 FT /note="confirmed intron" FT misc_feature 587..599 FT /note="ctaactaaaatag, splice branch and acceptor" FT misc_feature 641..646 FT /note="gtaagt, splice donor sequence" FT misc_feature 693..708 FT /note="ctaattcttgttttag, splice branch and acceptor" FT misc_feature 728..733 FT /note="gtttgt, splice donor sequence" FT intron 728..775 FT /note="intron confirmed by est" FT misc_feature 762..775 FT /note="ttaacccaatgcag, splice branch and acceptor" FT misc_feature 869..874 FT /note="gttcgt, splice donor sequence" FT intron 869..912 FT /note="confirmed intron" FT misc_feature 899..912 FT /note="ttaacattatatag, splice branch and acceptor" FT misc_feature 1048..1053 FT /note="gtatat, splice donor sequence" FT intron 1048..1094 FT /note="confirmed intron" FT misc_feature 1085..1094 FT /note="ttgatatcag, splice branch and acceptor" FT CDS join(complement(4006..4048),complement(3876..3961), FT complement(3783..3819),complement(3737..3742), FT complement(3660..3684),complement(3542..3610), FT complement(3282..3351),complement(3120..3193), FT complement(2976..3075),complement(2333..2920)) FT /db_xref="GOA:P78814" FT /db_xref="SWISS-PROT:P78814" FT /label=srp2 FT /note="SPAC16.02c, len:365" FT /gene="srp2" FT /gene="SPAC16.02c" FT /product="putative pre-mRNA splicing factor" FT /protein_id="CAB57400.1" FT /translation="MSETRLFVGRIPPQATREDMMDFFKGYGQILDCKLMNGFGFVEVE FT DARDARDIVNDFQGKEFMGSRIVVEPARGERRRRENFRESAASKYPRPRRTGFRLIVEN FT LSEDVSWQDLKDVMRKAGEPTFTDAHRENPGAGVVEFSTEEDMRNALTSLNGEVIKGQA FT VTLREDPDAANEPLPEVPSRFRSRSPPARRRYRDDYRRGGDYRRDAYRPGRDDERRYAP FT RGEYRRNNRDEYRRGGRDEYRRNSRSDYRRPHDDEYRRPRGDEYRPGRDEYRRSRDDGR FT PSHDDEYRRDAYSRSPSPRRDREENRSPAYEGSKSYSAAPEASMESSAPTESYDKPAAS FT EEQQPLQNHSDVGNGSAEGQVAAEW" FT misc_feature complement(2921..2934) FT /note="ctaacgattagcag, splice branch and acceptor" FT intron complement(2921..2975) FT /note="confirmed intron" FT misc_feature complement(2970..2975) FT /note="gtaagc, splice donor sequence" FT misc_feature complement(3076..3090) FT /note="ctaactttaatgcag, splice branch and acceptor" FT intron complement(3076..3119) FT /note="confirmed intron" FT misc_feature complement(3114..3119) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(3194..3209) FT /note="ttaacacttttcatag, splice branch and acceptor" FT intron complement(3194..3281) FT /note="confirmed intron" FT misc_feature complement(3276..3281) FT /note="gtaaga, splice donor sequence" FT misc_feature complement(3352..3363) FT /note="ctaacgtatcag, splice branch and acceptor" FT intron complement(3352..3541) FT /note="confirmed intron" FT misc_feature complement(3536..3541) FT /note="gtacgt, splice donor sequence" FT misc_feature complement(3611..3623) FT /note="ctaatgttcgaag, splice branch and acceptor" FT intron complement(3611..3659) FT /note="confirmed intron" FT misc_feature complement(3654..3659) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(3685..3701) FT /note="ctaatcttataaaaaag, splice branch and acceptor" FT misc_feature complement(3731..3736) FT /note="gtatgc, splice donor sequence" FT misc_feature complement(3743..3754) FT /note="ctaacagtttag, splice branch and acceptor" FT misc_feature complement(3777..3782) FT /note="gtacgt, splice donor sequence" FT misc_feature complement(3820..3833) FT /note="ctaacttgatgtag, splice branch and acceptor" FT intron complement(3820..3875) FT /note="confirmed intron" FT misc_feature complement(3843..3962) FT /note="Match to PF00076 rrm, RNA recognition motif. (a.k.a. FT RRM, RBD, or RNP domain) Score 20.68" FT misc_feature complement(3870..3875) FT /note="gtaaat, splice donor sequence" FT misc_feature complement(3962..3976) FT /note="ttaacaaaaatttag, splice branch and acceptor" FT intron complement(3962..4005) FT /note="confirmed intron" FT misc_feature complement(4000..4005) FT /note="gtttgt, splice donor sequence" FT CDS join(complement(5772..5888),complement(4798..5694)) FT /db_xref="GOA:Q9UTI0" FT /db_xref="SWISS-PROT:Q9UTI0" FT /label=SPAC16.03c FT /note="SPAC16.03c, len:337, SIMILARITY:Ustilago maydis, FT PYRC_USTMA, dihydroorotase, (391 aa), fasta scores: opt: FT 914, E():0, (45.0% identity in 358 aa)" FT /gene="SPAC16.03c" FT /product="putative dihydroorotase" FT /protein_id="CAB57401.1" FT /translation="MSLKIPGLADMHVHLRQDNMLKAVVPTVAEGGVSVAYVMPNLIPP FT ITTVDACLQYKKEIEQLDSKTTYLMSLYLSPETTPEVIYEAAKKGIRGVKSYPKGATTN FT SESGVESYEPFYPTFAAMQETGMILNIHGEVPPSKDNTVFTAEPKFLPTLLDLHQRFPK FT LKIVLEHCTTADAVEAVKACGESVAGTITAHHLYLTQKDWQDDPYCFCKPVAKTERDRR FT ALIEAATSKNPKFFFGSDSAPHPRSSKLKTPPAAGVFTQPFAASYLAEVFDKEGRLDAL FT KDFACIFGRKFYCIPLDFKESNIVLKKESFRVPESVANDLVPFHPNEVLQWHCSWE" FT misc_feature complement(5695..5710) FT /note="ttaacgcgtataacag, splice branch and acceptor" FT misc_feature complement(5766..5771) FT /note="gtatgt, splice donor sequence" FT CDS join(6767..6807,6856..8668) FT /db_xref="GOA:Q9UTH9" FT /db_xref="SPTREMBL:Q9UTH9" FT /label=SPAC16.04 FT /note="SPAC16.04, len:617, SIMILARITY:Saccharomyces FT cerevisiae, YL01_YEAST, hypothetical 69.8 kd protein in FT bdf1-sfp1 intergenic region., (609 aa), fasta scores: opt: FT 1279, E():0, (41.0% identity in 549 aa)" FT /gene="SPAC16.04" FT /product="conserved hypothetical protein" FT /protein_id="CAB57402.1" FT /translation="MAELETGAVPIREEFLVKQDGNKKRKRKERGQNKRREKIHVKENN FT ALCPAISIGNECPYKENCKFPHDVEAYLATKAPDIGDKCPIFERYGVCPAGFKCRWLAG FT HVVINADGKYELIKKPDGQFTLFTVNTVGKEVQRKLRTKQLDLSKAESIISAVLGEEKP FT DPSSKVSNIPEENRDATSAISEGKETESVSLEETGVLKNQTVSVNVDLKEISSQARSNI FT ALPTLRPQEKNLIDWRDRKILAPLTTVGNPPFRRLCGSLGADTFYSEMAMCYPLMQGHQ FT PEWALVRGLNYEREMMRGGRRGILGVQLATGKLWQATKTAQVIAEQCDGVDFLDLNCGC FT PIDLVFRQGAGSSLLENPGRLLRNLQGMDAVSGQIPVTVKLRMGNKDDHPVVKNLIGRI FT FNETNTSAATLHGRSRQQRYSKNANWDYIGEIASKVKSMNERIDELPEDSLRTQPLSLI FT GNGDCYSWQDWYDGVNKGVDTVMIARGALVKPWIFEEIEARQFIDKSSTQRLEMLEQYC FT NNGLEYWGSDSQGVNTTRRFFLEFMSFFHRYTPIALYEVQRPRLNDRPPLYTARDEMET FT LLASNKVTDWVKLSEFFLGPTPERFTFTPKHKSNSVEEAEG" FT misc_feature 6808..6813 FT /note="gtatgc, splice donor sequence" FT misc_feature 6841..6855 FT /note="ctaactataccttag, splice branch and acceptor" FT misc_feature 7538..8479 FT /note="Match to PF01207 UPF0034, Uncharacterized protein FT family UPF0034 Score 137.34" FT CDS complement(9387..10715) FT /db_xref="SPTREMBL:Q9UTH8" FT /label=SPAC16.05c FT /note="SPAC16.05c, len:442, SIMILARITY:Saccharomyces FT cerevisiae, SFP1_YEAST, zinc finger protein sfp1., (683 FT aa), fasta scores: opt: 213, E():0.00011, (25.3% identity FT in 513 aa)" FT /gene="SPAC16.05c" FT /product="hypothetical zinc finger protein" FT /protein_id="CAB57403.1" FT /translation="MPSLALPINKPSHHNVNYNGNSFNSIHATSFGMSPQSWGNSFSGQ FT AWLRDTIPSLSNVVESQTIPEEDSTSYLNRLEEAFCRDFRCCGQTLEDLHQLIHHYEEQ FT HAVLATDSAVPQEYSLDSNNAAQSNHSHIQALKQRERIRMHDLADQLGTSEISDNSAVL FT PFAFPANGGAPGPYRVSVVVPAAAAAAAAAASSDMSSDEASSQAETTGTPKKMPESLVM FT DASSPLSDMSMSIDVGESAANNVFAFNQKDMVDSTYLPPFNYDHDVFSFAPSVASADQF FT TESSMSPTPEVVSPAATNSAISSPFVRKSSSDLEAKPSKKQRSTPAFSHDSPLTIDYPG FT SNLVVVDKPYKCPVPNCDKAYKNQNGLKYHKLHGHCSPITTPTPAPIPHQGFVVENKPY FT RCEVCSKRYKNLNGLKYHRTHSHLQVSMAQAQREVQMNFMRTA" FT misc_feature complement(9450..9521) FT /note="Match to PF00096 zf-C2H2, Zinc finger, C2H2 type FT Score 23.74" FT misc_feature complement(9591..9668) FT /note="Match to PF00096 zf-C2H2, Zinc finger, C2H2 type FT Score 26.57" FT misc_RNA complement(11404..11558) FT /note="mRNA not asssociated with an ORF" FT misc_feature 11827..11922 FT /note="nominal overlap with cosmid SPAC9E9 S. pombe FT chromosome 1" XX SQ Sequence 11922 BP; 3946 A; 2147 C; 2285 G; 3544 T; 0 other; gatctgcagt gaatcattct ttaagaaaaa tttgcataga aaaaacctca tacagtgttt 60 aatccgctcc ctattaaaaa gtacatgttg caatctcaac cgattagaag gtacgattct 120 atggcctaat atctttttgc ttcttttatt tcttctactc aaattcattt tctttaaata 180 ttaatatttt taaggaaact agtagttgta ggcgatggtg cctgcgggaa gacgtctttg 240 ttatccgttt tcactttggg atattttcct actgtaagta cagatgtcat aaaagtgagc 300 tttggcttat cgcatattgc acgatacgca aatacttatt gtcttttcta ccttatttat 360 ttatttattt actaacttac tggcgatagg aatatgtaat gcttttttct ctttatttcg 420 tagagttttt taataacagt tactataggt tccgactgtg tttgaaaact atgtttcaga 480 ttgtcgagta tgtgtgatta acaagttatt gagctttttc agttggttac agaaagttac 540 tttcccactg gtcccttttc tttgggtttt gctaatacat ttgatactaa ctaaaatagg 600 ttgatggaaa atcagttcaa ctggcattgt gggataccgc gtaagtactt ttttttctga 660 tgttaaaact atatgttatg tattcctgca tactaattct tgttttagag gtcaagagga 720 atatgaggtt tgtttcgtta ttaatagtga gaaatacgtc gttaacccaa tgcagagatt 780 aagaccaatg tcttacgcta aagcacacat tattttggtt gggtttgcga tagactctcc 840 tgattcactt gaaaatgttt ctacgaaggt tcgtttcatt aattgttttt tccagtcatt 900 aacattatat agtggattga ggaaattaat acactttgcc caaatgttcc gtttatttta 960 gtgggcatga aagccgactt aaggtcagat cccgttgcta ttgaagaaat gcgacgtcga 1020 aatcaaaatt ttgtaaaatc acaacaggta tatattaata attcaaacac gtgaatacta 1080 attcttgata tcaggctgaa ttagtagctc agcggattgg tgcgagaaag tatatggaat 1140 gttcttcatt gactggtgac ggcgtggacg atgtatttga agctgctact agggcagcac 1200 taacagttcg ggattcggaa aatgacaaga gttctacaaa atgctgcatc atttcataat 1260 tactaatatc ctaacgattg caaacattca tgtttcagtt tataggaaag cctatcagtt 1320 tatgcgacct acatttacaa aaagctgata gacttttttg cttttcttcg catttgttct 1380 ttgccgttgt ttcatttcgt tttcactttc acttctgtcg tttacttttt tctttttctc 1440 ccctatacct caaatttagt tcctatttta ttttgagact caggagtatt attattattt 1500 tcatcattat aatcttcacg catcggtcga acgacactag cctccttttt catttcatta 1560 agcaaaccgc attcagttat tattaccttt tttttttact cttaaacatc tttcattctt 1620 tttcagcatc tattgtcctc atgaaaacta ctttttgttt aaaagatcat aggactttat 1680 ttttagaact gccgcttgcg ctcattatga agtacaaaat tcatatatgt acatatgctt 1740 ttgttctctt aggctaatag aaaatgtcag ttttccttat tgatacattt aatacgtagg 1800 ctcacttcgc taagtaattt tatggggcgg tcaaattcaa aattctggct catttaagct 1860 aaatattaag acaccgccaa aggtatacaa ccatatcaaa atttatcacc tactaaagtt 1920 tcgagcctat ttttttctgg gcattaatgg gttggaaatc aagactggca agagttaaag 1980 tggtcactct catcaaacaa ctatgtgaaa ttatataccc tttaaacacc catactccaa 2040 caactaactt ttcttcgggc gttcacttca ttaagaacaa caaccaaaaa aaaacaacca 2100 aaatccatcc aaatgataaa gaatgacaaa tacgcggcaa aaatccggaa ctacactaaa 2160 aattacacat tcctttcatt cttgatcgta agaaaggaaa tcgccaataa agagagataa 2220 attcatactc aaatacatca cagacaaagg atattaagac cacagacata tgacaggaaa 2280 atctagtaag cagacactaa aaaatagttt accaaaggaa aaatttctat gtttaccatt 2340 cagcagcgac ctgtccttca gcgctaccgt tacctacatc agaatggttt tgcaaaggct 2400 gttgttcttc cgaagcagca ggtttgtcat atgattcagt gggagcagat gactccattg 2460 atgcttcagg agcagctgaa taggatttgg aaccttcata ggcaggggag cgattctctt 2520 ctctatcacg tctaggagaa ggactacggc tataagcgtc acgtcgatac tcatcatcat 2580 gggaagggcg tccatcatca cgagaacgac ggtattcgtc tcgtccaggg cgatattcat 2640 cacctctagg acgacgatac tcatcatcat gaggacgacg ataatcactt ctggaattac 2700 gtctatactc atcgcgacca ccacgacggt attcatcacg attattacgc ctgtattcac 2760 cacgaggagc ataacgacgt tcatcatctc tgccgggacg ataagcgtca cgacggtaat 2820 cgcctcctct acgataatca tcacgataac gacggcgagc aggtggagaa cgtgaacgga 2880 agcgggaggg tacttcggga aggggctcat tagcggcatc ctgctaatcg ttagaaaatt 2940 tacgcaagga tctttaaaaa agattagatg cttacagggt cttcgcgtaa agtaactgct 3000 tggcctttaa tgacttcacc attaaggctc gtcaaagcgt ttctcatatc ctcttcagta 3060 gaaaattcaa caacactgca ttaaagttag gtgaaaaaat gatcaaagta gaaacttacc 3120 cagcaccagg gttttcacgg tgagcatctg tgaaagtggg ttcaccagct ttacgcatta 3180 catccttcag gtcctatgaa aagtgttaac actgaaatat agatatatga aaaaaatcat 3240 gcattgacgc aaaggtcatt aaatgtataa aattgtctta cctgccaact gacatcttct 3300 gagagatttt ccacaatcaa acggaaaccg gtgcgacggg gacgggggta tctgatacgt 3360 tagtataaaa atattgccgt aatttttata ggacaatgcg attttgcaag cgataacacc 3420 gtatatagtc actactcaga gctgattcac atgtgaagtg aacaaaatcg ttagaaccag 3480 caatcgcgtg caatgccaaa tcgcccacta atcacatatt aatggaaacg taacaacgta 3540 cttagaagca gcactttctc taaagttctc tcttcttctt ctttcaccgc gagcaggttc 3600 tacaacaata cttcgaacat tagcatattt taatctaaat tcataatgta ttgacttacc 3660 ggctgcccat aaactctttg ccctcttttt tataagatta gtaaataaag tcgaatatta 3720 aacctttgaa gcatacgaaa gtctaaactg ttagcaaaag ttttaagatg gtatgaacgt 3780 accatttacg atatcacgag catcgcgagc gtcttcaacc tacatcaagt tagtcacata 3840 gggattacaa aaagaaggct aatggtttta tttacctcaa caaagccaaa tccattcatc 3900 agcttgcaat caaggatttg accgtaacct ttaaaaaaat ccatcatatc ctcgcgagtc 3960 gctaaatttt tgttaaaata ctatttacat tatttagtta caaaccttga ggaggaatac 4020 ggccaacaaa caatctagtc tccgacattt ttttttggtg tagttggttc ttgctgggtg 4080 aagttcgacc ctcagtcggc agtcttgagg ctgaaggccg gcgaaaccca agttacaaaa 4140 tataagataa tgaaataaaa tataaaatca aattaaaaga gatggtgtta atcaaacctt 4200 gtctaacgat tttatgcatt catcggtcca cactttttcc taatattgta taaatgaaat 4260 ctgagtaact atcaaccata cttcagagtg tctattgaaa tgattaagaa ggttagataa 4320 taattaatta atggatcaag atggcgatga taatttcatc gacgggatac tgtaagttta 4380 attaatcatg attaaggagc taggatatct agtagtcaag atgcaacttc aagaagtaac 4440 tgttgtcttt acagtcatgt acgtaggttc ttatacgtat aattttcttt ttctatatta 4500 attataaata actataaagt attttagtaa acttcaatga ataatccgaa tttgagataa 4560 tgaaaacaag tttctgctca ttcaccagtt ctctatctgg atgaaaaact ttacgaaaat 4620 tttggaattc tgaaaagact cttgccagat gacacgcaat gtttgcattc gccgacgcat 4680 aatgattaac ccaattaact tcaaatgtta tttaaaaatt cgtaaatcca aaacataaaa 4740 gccgacaagt tcaaaaaaat agatagaaaa aaaaacacat aatcaacatg tactgaatta 4800 ctcccatgaa cagtgccatt gaagaacttc gtttggatga aaaggaacca aatcattggc 4860 aacactttca ggtacgcgaa acgactcctt ttttaagacg atattagact ctttgaagtc 4920 taaaggaata caataaaatt tcctaccaaa aatacatgca aaatccttca aagcatctaa 4980 acgaccctct ttatcaaaca cttcagctaa gtacgaagca gcgaaaggtt gggtaaaaac 5040 accagctgcc ggtggcgtct tcagtttaga agacctagga tgaggtgcag aatcactccc 5100 aaagaaaaac ttgggatttt tactggtagc agcttcaata agagcacgtc ggtctcgttc 5160 ggttttggct accggcttgc agaaacaata aggatcatcc tgccaatctt tttgtgtgag 5220 ataaagatga tgggcagtta tagtacccgc aacactttca ccgcatgctt ttactgcctc 5280 aacagcgtcg gcagtggtgc aatgttcaag cacaatcttg agttttggaa atctttggtg 5340 aaggtctagt aaagtaggaa gaaacttggg ctcagccgta aaaacggtgt tatccttaga 5400 ggggggaact tctccgtgaa tgttcagaat catacctgtt tcttgcattg cagcaaaggt 5460 aggataaaag ggttcgtagc tttcaacacc actttcagaa ttggtagtag ctcctttcgg 5520 atatgattta actcctcgaa ttcccttttt tgcagcttcg taaataacct caggtgtagt 5580 ttccggtgag agataaagac tcattaaata ggtggtcttg gagtcaagct gctcaatttc 5640 ttttttatat tgcaaacagg catcaacggt agtaattggg gggattaaat taggctgtta 5700 tacgcgttaa aaagttaaac ctttgtaacc ttcaaataaa ttttttgaat agcacaatac 5760 ttattacata ccattacata cgcaacagag actccaccct ctgcgaccgt tggaactaca 5820 gcttttaaca tattatcttg ccttagatga acatgcatat cagccaaacc aggtattttc 5880 aaactcatct tgtataggta gtgggtattg tcaagttgag taactagaaa ggtgcacttt 5940 atacttagtg ctaaattaaa ccaagaataa acaatcttaa caattggtaa aaaaatacta 6000 cttaaaatta gtatgtttct ttcaatataa attagtgagg gtaatataat tacttcaaaa 6060 aaatttacta taccgataat tctccaacta atttcaaaga tttaattgat cggagttaaa 6120 ccaaatatta tttcttaatt ctttttatta aagttcagat gcctaattct aaacataaga 6180 attcaccaac agcttaatta ttagaccacc gtcctgactc ttcggaagca tagagctact 6240 tgcttaatca ttgaagctcc attattagat ctaccttagt ataaaagaaa tccgaaacgt 6300 gtaactacta gcatttcctg tttatgtgta aatatacagg tacataatat gaagaattat 6360 ggtcatcagt acaaagcagt ttaaatttaa cttagtaata tcttggcatc tgaagaatat 6420 acaactcaat gaatagcagc atctcaaaag tgtgcattct aaacgtcttt aagatttata 6480 catttctaat ttcaatagac agttacagcc attgttacgt tttacaaaac ataactgtgt 6540 acctaaaagc atatagcgtt aatattacta tgcagtttta gagttttttt ttatctatta 6600 ggcaatatga ttgcttttcg aatctatcat gtaaaccgtt aattttgaat attgcactgc 6660 tacgtcgtat cttattttca cagacgcgca cagaatctag agaaaatatg cagtttgcat 6720 aaagcaaact actaaattca agggaaatcg gatttttggg tacttaatgg cagaattgga 6780 gactggagcg gttcctattc gggaagagta tgcttgaacc tcgctttcaa tagtcaatta 6840 ctaactatac cttagatttt tggtgaaaca agatggaaat aaaaaacgaa agcgtaaaga 6900 gaggggtcaa aataaacgga gagaaaaaat tcacgtaaaa gagaacaacg ctctttgtcc 6960 agctatatct attgggaatg agtgtccata taaagaaaac tgcaaattcc cacacgatgt 7020 ggaggcttac cttgctacca aggcacctga cattggagac aaatgcccta tattcgagcg 7080 gtatggagta tgcccagctg gtttcaaatg tcgctggcta gcgggccatg ttgttatcaa 7140 tgcagacgga aagtacgagc ttataaaaaa acccgatggg cagtttacgc tttttaccgt 7200 aaatactgtt ggaaaagagg tacagagaaa gctaagaaca aaacagttag atctatcaaa 7260 ggctgaaagt attatatccg cagttttagg tgaagaaaag cccgaccctt cttcaaaagt 7320 atccaatatt cctgaggaaa atagagatgc cactagtgct atttccgaag gaaaagagac 7380 agaatctgtt tcactggaag aaactggggt gttaaaaaat caaaccgtct cggtcaatgt 7440 cgatttaaaa gaaatctctt cacaagctcg gtcaaacatc gctttaccta ctttacggcc 7500 tcaagaaaaa aatctcattg actggcgaga cagaaagatt ctagctcctc ttaccaccgt 7560 tggaaatcca ccttttcgtc gtctttgtgg ctctctgggt gctgatacgt tttactccga 7620 aatggcgatg tgttatccac ttatgcaagg tcatcaacct gagtgggctc ttgttcgtgg 7680 gctaaactat gagcgtgaaa tgatgcgagg tggtcgtcgt ggtatattag gggtccaact 7740 agctaccgga aaactttggc aggccactaa aactgcacaa gtaatagctg aacaatgtga 7800 tggcgttgat tttctcgatt taaattgcgg ttgccctata gatttggtat ttcgtcaagg 7860 cgccggttct tctcttctcg agaatcctgg caggttactt cgtaatctcc aaggtatgga 7920 tgcggtatct ggccaaattc ctgtcaccgt aaaacttcgt atgggaaaca aagacgacca 7980 cccagttgtc aaaaatttaa ttggtagaat tttcaacgaa acaaacactt cagctgctac 8040 attacatgga agatctcgcc aacagcgata tagtaaaaac gcaaattggg attatattgg 8100 tgaaattgct tctaaagtaa aaagtatgaa tgagagaata gatgaacttc ctgaggactc 8160 cttgcgtacc caacctcttt cgctgattgg aaatggagac tgttattcat ggcaggattg 8220 gtatgatggt gttaacaagg gtgttgatac tgtgatgatt gcccgaggtg cactcgttaa 8280 gccatggatt tttgaagaaa ttgaagctcg tcagtttatt gataagtcat caactcaacg 8340 actcgaaatg ttggaacaat actgtaataa tggtttagag tattggggtt ctgactctca 8400 aggagtcaat acgactagga gatttttctt ggagtttatg agctttttcc atcgttatac 8460 acctatagct ttgtacgaag ttcaaaggcc cagattaaat gatagaccgc ctctatatac 8520 cgcgagagat gagatggaaa ctctcttggc cagtaataaa gttacggact gggttaaatt 8580 gagtgagttc ttcctaggtc ctactcctga gcgattcacc tttacaccaa agcacaaaag 8640 caatagtgtg gaagaggcag agggataaac aacttatggt cttagtgtat cgagcattca 8700 ctttcttcat atgcatcatc aacttttcat acttaatact ggcttatcat ctggattgaa 8760 ttaagtagat taataaaata tctggtgact tatatacgag tgatctgtgt ttgtctcgta 8820 aaatgcgcaa atgactaggc aaattggtaa tgaatctaac gttatatagt caacttaccc 8880 aatgggaact aaccaacgat cttacagtac tctacaatta ctatcgaaac tacgttgtga 8940 aataacttag caaatatatg gtaaataaca ctgccataca tatttattaa cttaaaaggt 9000 ataataataa cagcaagagg atatttggta caaaaataac ttaatacaca ataaaaacca 9060 ttaaaaatcc agaatcccaa aatgacaaaa caaaaaatta aaaaacaaaa aaaaagcaaa 9120 caaaacaaac acagccatca tgtaggtaat aaagtaagtg caaaattaac gggaatgaat 9180 caaaggagac aggttcactt tacagctaat tcgattgttg tatgcagata aatgcaagcc 9240 cgtaaacatc aagcaaactc cacacaacat gtctaccctt ctcaaactta aaagcaaaga 9300 tagacataaa agtattcaaa cttgaagata cgaaactgag atacaaatct catgttcaaa 9360 tattacaaag gcaaaaaaga gcatatttat gcggtgcgca taaagttcat ttgaacttcc 9420 cgttgagctt gggccataga cacttgtaga tgactatgtg tacgatgata tttcaaaccg 9480 tttaagtttt tatatctttt actacaaact tcacagcgat aaggcttgtt ttccacaaca 9540 aacccttgat gaggaattgg agctggtgtt ggagtagtaa tgggggaaca gtgtccatga 9600 agtttgtgat acttcaaacc attttgattc ttataagcct tatcacaatt agggacaggg 9660 catttgtatg gcttgtctac aaccaccaag ttagagcctg ggtaatcaat agtgagcggt 9720 gaatcgtgtg agaatgcagg agtagaacgc tgctttttag atggcttagc ttccaaatca 9780 ctagaagatt tcctaacaaa tggggatgag attgctgagt ttgtggctgc gggtgaaact 9840 acttcaggag taggagacat gctagactct gtgaattgat cggcggatgc gacagatgga 9900 gcaaatgaaa aaacatcgtg atcgtaattg aatgggggaa gatatgtaga gtcaaccatg 9960 tccttttgat tgaacgcaaa aacattattg gcagcggact caccaacgtc aatagacatg 10020 ctcatgtcac tgagagggga gcttgcatcc attaccaatg attcaggcat ctttttcggg 10080 gtaccagttg tctctgcttg actactggcc tcgtcactgc tcatgtcgga gctggcagcg 10140 gcagcagcag cagcagcagc ggcaggtacg acaacggaaa cgcggtaagg gccaggagca 10200 ccaccgttag caggaaaggc aaatggtaaa acagcagaat tatcagaaat ttcagaagtt 10260 ccaagctgat cagcaagatc atgcatacgg atgcgctcac gctgtttgag cgcttgaata 10320 tgagaatgat tagattgagc agcgttgttg ctatccaaag aatattcttg aggaacagca 10380 gaatcagttg ccagaacggc gtgctgctct tcataatggt gaataagttg atgcaaatct 10440 tcgagagttt gaccacagca gcggaaatca cggcaaaatg cttcttctaa ccggtttaga 10500 taagaggtag aatcctcttc gggaatcgtt tgtgactcaa ccacgttaga aagagatgga 10560 atagtatcac gaagccaagc ttgtccacta aagctatttc cccaagactg tggactcatt 10620 ccaaaagagg tagcatgaat gctgttaaag gaatttccgt tgtagttgac attgtgatgg 10680 gaaggcttat tgataggcaa tgcgagagat ggcatattga aaagttttta agggaattaa 10740 taaaattaaa gagataaaag agaaaattaa aagataaacc gataaataga aaccaaatta 10800 aaaattatat accaatgatg aaaaaataga ataaaaataa caaaataatt tagtaagtta 10860 ttttttgaga aatcagggaa taatgcactt agaaaactcg acttaaggaa ggcaagttct 10920 tagagagcgc tgagaggggt aaaaaaaggc aattaaaaaa agactgaatg taaaatctaa 10980 tgaaattcga cgaactataa attcgaaaaa aaaaggaaaa agtttctaaa agaagaattt 11040 accaagcaaa aaaatgaagg taaactattt ttaagcacta aattacccaa gtgtaattag 11100 tgtattgtaa tgttttaagt ggaaacccca aagtgactta tctaattttt tcagtctaaa 11160 caaattggcg attaacggat gataaatgta taatataaat aagatgaaaa gaaagggagt 11220 aaaaaccttt taaagaatcc tttttaatca acaaagaaag tcaagtaata acgaatcgag 11280 tcgaggaaac tgttcgattc gacttttttt taaaataaag cgaaatagta aataatttac 11340 gctttgattc aatgaacaat cgagatcaat cgaaaagagt ggtgatactt caaaagagta 11400 atcttttttt tgcaggcaac tagtggacgc aatatatgtt gcaagcgaat tttttttata 11460 aatatgttta atttttttta agttgaatat atggtattca acaacaattc tatgattgta 11520 ctaactccct taagttaagt aagtatattt gcttctgctt ccttcgtgtc gtcctcacgt 11580 tgaagttagt cagaataagg cgttaagaag ggtaggacgg tgtttaagta gtaattgata 11640 aggtgattta gcaagccttc tcgttacgta tgtataaagg taacaaggat aaaagggtca 11700 agtaacagtg acgccgacta tgcgagcgaa taacagtgaa gctttcagac ttaaacacct 11760 aatgaggggc ccttaaatat aagaaagcca atcagagtac acagagtgga tcgaacttgg 11820 atcaaagtaa ttaggggtaa caatgcaact tcgtcagtgc cgtatcggaa ggtcgttact 11880 tccaatagat ggggccgaag acaaggggcg aatagtttct ag 11922 //