ID SPAC15E1 standard; DNA; FUN; 12855 BP. XX AC AL109770; XX SV AL109770.1 XX DT 09-AUG-1999 (Rel. 60, Created) DT 25-NOV-1999 (Rel. 61, Last updated, Version 2) XX DE S.pombe chromosome I cosmid c15E1. XX KW acetyltransferase complex subunit; actin-interacting protein; ard1 family; KW fat1; glutaredoxin; phosphoethanolamine cytidylyltransferase; KW ribosomal protein l44; thioltransferase; KW thymidylate synthase-like DNA metabolism protein; vacuolar sorting protein; KW yeast Bud6/Aip3p homolog. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-12855 RA Murphy L., Harris D., Barrell B.G., Rajandream M.A., Lyne M.H.; RT ; RL Submitted (09-AUG-1999) to the EMBL/GenBank/DDBJ databases. RL Schizosaccharomyces pombe chromosome I sequencing project, Sanger Centre, RL Hinxton Hall, Hinxton, Cambridge CB10 1RQ E-mail: barrell@sanger.ac.uk XX DR GOA; O13735; O13735. DR GOA; Q9UTI2; Q9UTI2. DR GOA; Q9UTI3; Q9UTI3. DR GOA; Q9UTI5; Q9UTI5. DR GOA; Q9UTI6; Q9UTI6. DR GOA; Q9UTI7; Q9UTI7. DR GOA; Q9UTI8; Q9UTI8. DR SPTREMBL; Q9UTI1; Q9UTI1. DR SPTREMBL; Q9UTI3; Q9UTI3. DR SPTREMBL; Q9UTI4; Q9UTI4. DR SPTREMBL; Q9UTI5; Q9UTI5. DR SPTREMBL; Q9UTI7; Q9UTI7. DR SPTREMBL; Q9UTI8; Q9UTI8. DR SPTREMBL; Q9UTI9; Q9UTI9. DR SWISS-PROT; O13735; FAT1_SCHPO. DR SWISS-PROT; Q9UTI2; GLR2_SCHPO. DR SWISS-PROT; Q9UTI6; ECT1_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe) CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPAC5H10.01c. CC SP (S. pombe), A (chromosome 1), c5H10 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c15E1 is overlapped at the 5' end by cosmid c15A10. XX FH Key Location/Qualifiers FH FT source 1..12855 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c15E1" FT /map="ICEN" FT misc_feature 1..35 FT /note="nominal overlap with cosmid SPAC15A10, EM:Z97208 S. FT pombe chromosome 1" FT CDS 1..1093 FT /codon_start=2 FT /db_xref="GOA:O13735" FT /db_xref="SWISS-PROT:O13735" FT /label=fat1 FT /note="SPAC15E1.01, len:>363" FT /partial FT /gene="SPAC15E1.01" FT /gene="SPAC15A10.15" FT /gene="fat1" FT /product="yeast actin-interacting protein Bud6/Aip3p FT homolog" FT /protein_id="CAB52420.1" FT /translation="NVVEKFDEVNDQIELMRSDVLLRKVRPGLDQTSQLNEESAYLEKR FT IQTLERSLEEVTPIWKKQWERELNAIVQEQEFLDSHTVLISDLKRDLSALSTVLSNVSA FT IAELQAKSSIKSKPLTLKTATESEIKGYRDQIQLEVLNLKPDSEARLQAIERSELLQKK FT RLLQRVDEFSKEVKTFVENEKLNKIGGAEEADRIRTIQDEKVRKILWDDFVSSKRNGKN FT GGSFIEESSDTVLDEHVVPDNSAKATVAEIDYGSQVDTENFMLERSPLATPKPLKQPDF FT NIYETPIVRSTAHETDDEQTPSKYSDNRVESSSDTVFENTDLKYDNNVQMSKVTHHVRH FT DTISTDDYDAYEDAEDVEETSLT" FT CDS complement(1440..1886) FT /db_xref="SPTREMBL:Q9UTI9" FT /label=SPAC15E1.02c FT /note="SPAC15E1.02c, len:148" FT /gene="SPAC15E1.02c" FT /product="hypothetical protein" FT /protein_id="CAB52421.1" FT /translation="MPSYTHMPYVRPSAILLGIAFDHAASFLVYGPLMGDIWKRAMSTA FT PHVEYDAGSKTKKVATTYVSNFLSTAVQSYSIAALLQLTGTVTLKGAFFVGLYVFGASG FT LPDVVDYMFTESRGTPYILVKTISSLVKSVGLSVALIGYGVRRI" FT CDS join(2639..2938,3129..3149) FT /db_xref="GOA:Q9UTI8" FT /db_xref="SPTREMBL:Q9UTI8" FT /label=SPAC15E1.03 FT /note="SPAC15E1.03, len:106, SIMILARITY:Phaffia rhodozyma, FT RL44_PHARH, 60s ribosomal protein l44, (105 aa), fasta FT scores: opt: 608, E():0, (81.9% identity in 105 aa)" FT /gene="SPAC15E1.03" FT /product="60s ribosomal protein l44" FT /protein_id="CAB52422.1" FT /translation="MVNIPKTRKTYCPGKNCRKHTVHRVTQYKKGPDSKLAQGKRRYDR FT KQSGFGGQTKPVFHKKAKVTKKVVLRLECVSCKYKNQLVLKRCKHFELGGEKKTKGAAI FT QF" FT misc_feature 2693..2923 FT /note="Match to PF00935 Ribosomal_L44, Ribosomal protein FT L44 Score 174.98" FT misc_feature 2939..2944 FT /note="gtatgt, splice donor sequence" FT intron 2939..3128 FT /note="confirmed intron" FT misc_feature 3113..3128 FT /note="ctaacaatcattttag, splice branch and acceptor" FT CDS 3963..5840 FT /db_xref="GOA:Q9UTI7" FT /db_xref="SPTREMBL:Q9UTI7" FT /label=SPAC15E1.04 FT /note="SPAC15E1.04, len:625, N-term SIMILARITY:Candida FT tropicalis, SIS2_CANTR, SIS2 PROTEIN (HALOTOLERANCE PROTEIN FT HAL3), (531 aa), fasta scores: opt: 613, E(): 1.3e-29, FT C-term SIMILARITY:Saccharomyces cerevisiae, TYSY_YEAST, FT thymidylate synthase, (304 aa), fasta scores: opt: 1403, FT E():0, (65.7% identity in 303 aa)" FT /gene="SPAC15E1.04" FT /product="thymidylate synthase-like DNA metabolism protein" FT /protein_id="CAB52423.1" FT /translation="MSQPLHARFATRAVKNPMILEKERQLTDSKYHILVAATGSVAAIK FT LTLIVKSLLTYKGVDVQVVLTDPARNFVEKEDLTALGVNVYNNADDWKNWDGLECPITH FT IELRRWAHLLLIAPLSANTMAKMANGLCDNLLTSLIRAWAPLKPILLAPAMNTLMWTNP FT ITQEHLSAISRIYKNSEFIMPIEKVLACGDIGMGGMAEWRNIVGRVADKLQLEQKSVLP FT NAVKNIDGQDDDSSEQTAAFEEYDDDDDDDVDDNEQSNSMIETSANADITPKASLLPST FT TESSISKDHETSQAPLGSESVDTQASENVTTKPEPPVPFTSSEYRNTEEEQYLNLIRYI FT LENGQSRPDRTGTGTRSVFAPPQLRFSLRNNTLPLLTTKRVFLRGVLEELLWFIHGDTN FT ANHLSEKGIHIWDGNGSREFLDSRGLTDRKVGDLGPIYGFQWRHFGAQYVDCDTDYTNK FT GVDQLAQVISTLKLNPYDRRIILSAWNPLAIPEMALPPCHIFCQFYVSEPCKPGGKPQL FT SSMMYQRSADMGLGVPFNIASYSLLTHMIAHMCGYEAAEFVHVMGDCHIYNDHLEALQT FT QLERVPKAFPKLFFKRDAKDIGSIDSFSVDDFAVEGYNPYGPIKMKMSV" FT misc_feature 4944..5837 FT /note="Match to PF00303 thymidylat_synt, Thymidylate FT synthase Score 685.78" FT CDS join(complement(7138..7204),complement(6052..7082)) FT /db_xref="GOA:Q9UTI6" FT /db_xref="SWISS-PROT:Q9UTI6" FT /label=SPAC15E1.05c FT /note="SPAC15E1.05c, len:365, SIMILARITY:Homo sapiens, FT Q99447, phosphoethanolamine cytidylyltransferase., (389 FT aa), fasta scores: opt: 713, E():0, (37.0% identity in 357 FT aa)" FT /gene="SPAC15E1.05c" FT /product="phosphoethanolamine cytidylyltransferase (EC FT 2.7.7.14)" FT /protein_id="CAB52424.1" FT /translation="MASSSNIKHRLWLDGCMDFFHYGHSNAILQAKQLGETLVIGIHSD FT EEITLNKGPPVMTLEERCLSANTCKWVDEVVPSAPYVFDLEWMRRYGCQYVVHGDDIST FT DANGDDCYRFAKAADQYLEVKRTEGVSTTELLDRLLSSVPLEIYSTPVSVLSSQIDLLR FT RFATDSDGLTPFTDVFIYNTEKPETLISGTTLLRLNPEKNIIYIDGDWDLFTEKHISAL FT ELCTRMFPGIPIMAGIFADEKCFEKPMLNLLERILNLLQCKYISSILVGPPPASLFASS FT KYIKLCFDEQISKVYYPIFSTDVSIPALDISLSNTPNNSFYKFDKLGSDLIKQRVMLRR FT QHYEERQRRKMGKNATEQTTIKTYA" FT misc_feature join(complement(7138..7171),complement(6727..7082)) FT /note="Match to PF01467 Cytidylyltransf, FT Cytidylyltransferase Score 117.35" FT misc_feature complement(7083..7096) FT /note="ctaacactctatag, splice branch and acceptor" FT misc_feature complement(7132..7137) FT /note="gtagga, splice donor sequence" FT CDS join(7593..7655,7734..8234) FT /db_xref="GOA:Q9UTI5" FT /db_xref="SPTREMBL:Q9UTI5" FT /label=SPAC15E1.06 FT /note="SPAC15E1.06, len:187, SIMILARITY:Arabidopsis FT thaliana, CAB41864, hypothetical 21.0 kd protein., (190 FT aa), fasta scores: opt: 609, E():0, (45.7% identity in 186 FT aa)" FT /gene="SPAC15E1.06" FT /product="similar to yeast vacuolar sorting protein FT VPS29/PEP11" FT /protein_id="CAB52425.1" FT /translation="MLVLVIGDFHIPDRAPKLSEKFRQLLIPGKISQIICLGNLTSTSV FT YEYLKHVCSDLKLVKGAFDISSKAPIAGKITLGSFKIGYTNGHLVVPQDSPEALSILAR FT EMDADILLFGGTHKFAAYELDGCFFVNPGSATGAPNVSAVEDDEKIVPSFVLMDVQGAV FT LILYVYRIFDGEVRVEKMQYRKPE" FT misc_feature 7656..7661 FT /note="gtaaga, splice donor sequence" FT misc_feature 7712..7733 FT /note="ctaatttaaatattaaatgaag, splice branch and acceptor" FT CDS complement(8646..9164) FT /db_xref="SPTREMBL:Q9UTI4" FT /label=SPAC15E1.07c FT /note="SPAC15E1.07c, len:172" FT /gene="SPAC15E1.07c" FT /product="hypothetical protein" FT /protein_id="CAB52426.1" FT /translation="MAINNENELEYKLIKKNKNPKISNSKKKNSTRPALQDKTNQTLPI FT HQNQAFSNILPSDFSIIKTPETKTADDFPVNGYEGLNILKFDLELFYKLKPVATSTPKS FT CMRTGSNLFLNETVKHVPDERLVSNIKNTQTKDSITRDSAYYHRKTMTESIIKTLAAFD FT AEVDEIILF" FT CDS join(9937..10027,10114..10308,10624..10726,10774..10830, FT 11034..11121) FT /db_xref="GOA:Q9UTI3" FT /db_xref="SPTREMBL:Q9UTI3" FT /label=SPAC15E1.08 FT /note="SPAC15E1.08, len:177, SIMILARITY:Homo sapiens, FT ARDH_HUMAN, n-terminal acetyltransferase complex ard1 FT subunit homolog., (235 aa), fasta scores: opt: 691, E():0, FT (66.4% identity in 149 aa)" FT /gene="SPAC15E1.08" FT /product="putative n-terminal acetyltransferase complex FT subunit; ard1 family" FT /protein_id="CAB52427.1" FT /translation="MDIRPARISDLTGMQNCNLHNLPENYQLKYYLYHAISWPMLSYVA FT TDPKGRVVGYVLAKMEEEPKDGIPHGHITSVSVMRSYRHLGLAKRLMVQSQRAMVEVYG FT AKYMSLHVRKSNRAAIHLYRDTLQFDVQGIESKYYADGEDAYAMHKDFSTLKFDTPETN FT DELAKTVQSLALNN" FT misc_feature join(9943..10027,10114..10308,10624..10709) FT /note="Match to PF00583 Acetyltransf, Acetyltransferase FT (GNAT) family Score 56.38" FT misc_feature 10028..10033 FT /note="gtaagt, splice donor sequence" FT misc_feature 10100..10113 FT /note="ctaatttaatgtag, splice branch and acceptor" FT misc_feature 10309..10314 FT /note="gtaagt, splice donor sequence" FT misc_feature 10604..10623 FT /note="ctaactacttaaatgaacag, splice branch and acceptor" FT misc_feature 10727..10732 FT /note="gtatgt, splice donor sequence" FT misc_feature 10759..10773 FT /note="ctaacattattttag, splice branch and acceptor" FT misc_feature 10831..10836 FT /note="gtaagt, splice donor sequence" FT misc_feature 11020..11033 FT /note="ctaacaatttttag, splice branch and acceptor" FT CDS join(11401..11554,11802..11822,11870..11938,12023..12111) FT /db_xref="GOA:Q9UTI2" FT /db_xref="SWISS-PROT:Q9UTI2" FT /label=SPAC15E1.09 FT /note="SPAC15E1.09, len:110, SIMILARITY:Schizoscacharomyces FT pombe, O36032, hypothetical glutaredoxin-like protein, (108 FT aa), fasta scores: opt: 284, E():1.8e-14, (39.8% identity FT in 90 aa)" FT /gene="SPAC15E1.09" FT /product="putative thioltransferase (glutaredoxin)" FT /protein_id="CAB52428.1" FT /translation="MTSIAKAFVEKAISNNPVTVFSKSFCPFCKAAKNTLTKYSAPYKA FT YELDKIENGSDIQAYLHEKTKQSTVPSIFFRNQFIGGNSDLNKLRSSGTLTKMIAELKE FT NKSSIL" FT misc_feature 11555..11560 FT /note="gtaagt, splice donor sequence" FT misc_feature 11787..11801 FT /note="ttgatgttacactag, splice branch and acceptor" FT misc_feature 11823..11828 FT /note="gtgtgt, splice donor sequence" FT misc_feature 11841..11869 FT /note="ctgattttatcatatgcttacctgagcag, splice branch and FT acceptor" FT misc_feature 11939..11944 FT /note="gtatga, splice donor sequence" FT misc_feature 12005..12022 FT /note="ctaatacattatataaag, splice branch and acceptor" FT CDS 12573..12855 FT /db_xref="SPTREMBL:Q9UTI1" FT /label=SPAC15E1.10 FT /note="SPAC15E1.10, len:94" FT /partial FT /gene="SPAC15E1.10" FT /product="hypothetical protein" FT /protein_id="CAB52429.1" FT /translation="MNNPTSDDRLRFQQKCHKSMLNTGAIFKNCKLRNGDVLQEVTESL FT TEDSEFNYIVNESQNVSTRLIFWNKWIYILCANTSSNITATRIFRLDDD" XX SQ Sequence 12855 BP; 4047 A; 2231 C; 2398 G; 4179 T; 0 other; aaacgtagtt gaaaagtttg atgaggtaaa tgatcagatt gaacttatgc gttctgatgt 60 gctgttgcgc aaagtacgac caggcttaga tcaaacatct caattaaatg aggaaagcgc 120 atacttggaa aaaaggattc aaacccttga aagatctctt gaggaagtaa ctccaatttg 180 gaagaagcaa tgggaacgag agttaaatgc aattgtacaa gagcaagaat ttctggatag 240 tcatactgtt cttatatcag atcttaagag ggatctttcc gcattatcca ctgtcctttc 300 aaatgtttcc gcgatagctg aattgcaagc caagtcctcc attaaaagca aacccttaac 360 tttgaaaact gccactgagt ctgagattaa aggttatcgt gatcaaattc agctagaagt 420 actaaatcta aaacccgaca gtgaagcacg actacaggct attgagcgta gtgaactgtt 480 gcagaaaaaa cgactgttgc aacgagtaga tgaattttca aaagaagtta aaacttttgt 540 tgagaacgaa aagttgaata agatcggagg agcggaagag gctgatcgaa ttcgaacaat 600 tcaagatgaa aaagtacgta aaattctatg ggatgacttt gtgtcatcga aacgcaatgg 660 aaaaaatgga ggtagtttca ttgaggaatc gagtgacact gttttagacg aacatgttgt 720 gcctgataat tctgctaaag caactgttgc agaaatagac tacggttcac aggtggatac 780 agagaatttt atgttagaac gcagtccatt ggcaactcca aagccattga agcaacctga 840 ttttaatata tatgagacgc cgatcgtccg tagtacagct catgaaacag atgatgaaca 900 aaccccttct aaatactccg ataacagagt cgaaagttct agtgatacag tgtttgagaa 960 tactgatctt aagtacgata acaatgtaca gatgagtaaa gtgactcatc atgtaagaca 1020 cgatacgata tccactgatg actatgacgc ttacgaagat gccgaagatg ttgaagagac 1080 aagcctaact taatgtgcat aagttttatt cgatttggca atgattgtat gccagtttgt 1140 gtattttttt tttacttttt ttaactttaa ttgttacgag agaaattacc ctgtattaca 1200 ctaggactga tgcaaatctt gtgaatcaag gatttgctga atagagttac aacatacctt 1260 aatatgtaca gttataacaa gcaaaggaag cttcgatgtt gtccaatacc actattggga 1320 tactattttc acttacagtc taaccaaata tgagataaac acagaaaaga aatcttagat 1380 attaaagaaa atttgattaa cttgtcgttt taaaaatcag atattgaacc atcggaatct 1440 taaatacgac gtacgccgta accgatcaag gcaacactta agcctactga tttcactaga 1500 gaagatatag ttttgacaag gatgtaaggg gtacctctgc tttctgtgaa catatagtcg 1560 actacgtcgg gcaatccaga tgcaccaaat acataaagac ccacgaaaaa ggcacctttg 1620 agtgtcacag tgcctgtaag ttgcaacaat gcagcgatcg agtacgactg aactgctgta 1680 ctaaggaaat tgctaacata agttgtagca accttcttgg ttttacttcc agcgtcatat 1740 tcgacgtgag gtgcagtgct cattgccctt ttccaaatat cgcccattag gggtccataa 1800 acgaggaaag aagcagcatg gtcgaaggca atccccaaga gaattgcact agggcgtaca 1860 tacggcatgt gagtgtagga tggcatttct tgtattaata tttagtttga gttagaacaa 1920 gattaatatg aatgtgaata ttttgtaaaa taaatgtttt gtaattaaag gatttaaggg 1980 cgctaccact aaatatatag tatactcaag gtccaattat ggatttaggt acagattaat 2040 ttggggcgtc actttgacgt gtcgatgaag tatgataatt gggaaatact gcttagcctg 2100 acttgacttg ttttaagtcg ctatttcgct atttacatag tgatatctac atcattttcc 2160 taaacttttg gtggagcaat atctcatact gttcggatgc tgtgccaagt cttgcataaa 2220 gaaatcagtg aagtcgataa atataagatt tggagtgcag cgatggtaac aactagtgat 2280 taaaaataga aatttactac aataattttc gcatgtttta cattaaaaag ccctcacaga 2340 agaatcaaag ttggattgaa attccagcac taaaacaatg tagcttagaa attttgtttg 2400 ctggcccaca tttgatatat tgcaagcttg atcttacgca gtaaacactt ttagggtagc 2460 tatcggttgt tcacactatt gcgaacagtg cgttgaacga cattacagca gcaagtaaac 2520 ctaacctaga ggaataagaa acagtcacat ttgtacaaca agggtttagc agagaaactt 2580 tatgctgtcg agttcctaat caccaccatc taaccatcac ttataaaagt atcaaaaaat 2640 ggtgaacatt cccaagaccc gtaagactta ctgtcctggt aagaactgcc gcaagcacac 2700 tgtccacaga gtcacccaat acaagaaggg acctgattcc aagcttgctc agggtaagcg 2760 tcgttatgac cgcaagcaaa gtggttttgg tggtcaaact aagcccgttt tccacaagaa 2820 ggctaaggtt accaagaagg ttgtccttcg tttggaatgc gtctcttgca aatacaagaa 2880 tcaattggtt ttgaagcgtt gcaagcattt cgagcttggt ggtgaaaaga agactaaggt 2940 atgtcgaaga atgctgataa cgagtggatt ggatttagac gaatttgtaa aagagttttt 3000 gccgtggttg aatacctctc aaatccagaa aaaaaatttt gcaaagcgct tttatgaatt 3060 gtcttttgtt gagtttcatc cttattatcg atcattttct ttatttcatc tactaacaat 3120 cattttaggg tgctgctatc caattctaag tgttttagca aatacaattt tcttctttta 3180 cggtgatcct aaaagcaatt caaagtagtg tttcatttgt attgtataaa taatgacatg 3240 attccgatag agtagcacac aaagtgatga gttgtcatca attagcagtt cgctaacgct 3300 aaggtctgtt ctcaatattg gagcaatctt tttcgagtgt ttctagttcc atcggtttga 3360 gtcagagctt ttcaagactt gtattactgc ttgagtagaa gacaggtgtt gtgatttcgg 3420 aaaataaccc atcacatttg tcagcatgtt aactaagata aaagtaatca aacaagtaca 3480 gcgtaaaata gcgagagtac taaagcatca aatatgcttt caagtattgc aaaaaaattt 3540 tctttaaatt atccatgctt acgggtcttc taaggtttag gagactatgc catttgccga 3600 attatggata tattaagtaa ctaattgcta atagtgagag tgtagtgcat ccttgcataa 3660 cggcacttgg atttcacact gcaggcataa taaataatta cttttttttg gtactaaagc 3720 aacgtacgtt ctttgttttt ctgcgtacga cgtgtacaat tcccttgcaa aactaaggtt 3780 cgcttgttca attgctaaat ttgtttttgt ggacgaccat tataacgcgc ttcaatgagt 3840 ttataaaagt ttcattaaat tgcagtacca gataaatcga tatctaacct tctccctgca 3900 tctataatct ctagcttcac caacattaag gcccgtcaat tactttcgtt tcgttggcca 3960 atatgtcaca acctttgcat gccaggtttg ctaccagggc tgtaaaaaat cccatgatcc 4020 ttgagaaaga gcgacaactt acggattcta aatatcatat tttggtcgct gcaacgggtt 4080 cggttgcggc gataaaattg acattaatcg ttaaatccct actgacatac aagggcgtcg 4140 acgttcaagt cgttttaacg gatccggctc gtaactttgt tgagaaagag gacttaacgg 4200 ctttgggtgt caatgtttat aacaatgcgg atgattggaa aaattgggac ggactcgaat 4260 gtcctatcac acatattgag ctacgtcgat gggcacatct tttgttaatt gcccctttaa 4320 gtgcaaatac tatggccaaa atggcaaatg gtctctgtga caatttactt acctctctta 4380 tacgtgcctg ggccccttta aaaccaattc tcttggctcc cgcaatgaat accttgatgt 4440 ggactaatcc tataactcag gaacatttga gcgctattag cagaatatac aagaatagtg 4500 aatttatcat gccaatcgag aaagtgcttg cctgtggtga tattggcatg ggcggtatgg 4560 ccgaatggag aaacattgta ggcagagttg ccgataaatt gcagctagaa caaaagtctg 4620 tcttgccgaa cgctgtgaaa aacatcgatg gacaagatga tgactctagt gaacaaactg 4680 ctgcttttga agagtacgat gatgatgatg atgacgatgt tgatgataat gaacaatcca 4740 acagtatgat tgaaacttct gcaaatgcag atattacccc caaggcctct cttttaccct 4800 ctactacaga atcttctata agcaaagatc acgagacctc ccaagctcca ttaggctcgg 4860 aatcggtgga tactcaggcc tctgaaaatg ttactaccaa acccgaacct cctgtaccat 4920 ttacttcctc cgaatataga aatacagaag aagagcaata cctaaatttg attcgatata 4980 tccttgaaaa tggccagtcg cggcccgatc gcacgggaac tggtacgaga tcggtatttg 5040 ctcctccaca actacgcttt tctttaagga ataatactct acctcttctc actacaaagc 5100 gtgttttttt acgtggtgtg cttgaagagt tactttggtt tattcacggt gatactaatg 5160 ccaatcattt aagtgaaaaa gggattcata tatgggatgg caatggcagt agagaattcc 5220 tagacagcag agggcttact gatcgtaaag ttggtgacct cggtcctata tatggttttc 5280 aatggagaca tttcggagcg caatatgttg attgcgatac tgactatacc aataaaggag 5340 tggatcagct ggctcaggtt atatctaccc tcaaattaaa cccttatgac cgtcgtataa 5400 ttctttcagc ttggaaccca ttagctattc ctgaaatggc tttaccacct tgccatatat 5460 tttgccagtt ttatgtcagt gagccttgca agcctggggg aaagccccaa ctttctagta 5520 tgatgtatca gcgctctgcc gacatggggc ttggagttcc ttttaacatt gcttcttatt 5580 ctctcttaac acatatgata gctcacatgt gcggctatga agctgccgaa tttgttcacg 5640 taatgggtga ttgtcatata tacaatgatc atttagaggc attacaaact cagttggaaa 5700 gagttcctaa agctttccct aagttgtttt tcaaacgtga tgctaaagac atagggtcta 5760 ttgatagttt cagcgttgat gatttcgcag ttgaaggtta taatccttat ggccctatta 5820 aaatgaaaat gagtgtctaa ttattagcct ttcttatata cgtttgcttc gttgatgatt 5880 tttgaagttg aaacacaatt tctctgtaat agatttttta gttaatggat atcaaaagtt 5940 taatagcgat tgtatatgtt catttataaa agttgctaaa gcttatttaa aagaaacgac 6000 aagatgttta aaaggatatt atgctgttaa ttactaagac caggagcaaa attatgcgta 6060 agttttaatg gtcgtttgtt ctgtagcatt tttacccatt tttcgacgct gccgttcttc 6120 ataatgctgc cgacgtaaca taacccgctg cttaatcaaa tcagaaccca gcttatcaaa 6180 tttataaaaa ctattatttg gggtattgga aaggctaatg tcaagcgctg gtatgctcac 6240 gtcagtggaa aatattgggt aatatacttt cgagatctgc tcatcaaaac ataactttat 6300 gtatttagaa gatgcaaaca aagatgctgg tggaggacca acgaggattg aagatatata 6360 tttgcattgt agtaaattca agatacgctc taacagatta agcataggct tttcgaaaca 6420 tttctcatcc gcgaaaatac ctgccataat tggaataccc ggaaacattc gagtacagag 6480 ttctaaagca gaaatatgct tctctgtaaa caaatcccaa tcaccatcaa tgtatattat 6540 gttcttttcg ggattcaacc ttagcaaggt tgtgcccgaa ataagggttt ctggcttctc 6600 agtgttatat ataaaaacat cagtaaaagg agttagcccg tcggaatcag ttgcaaatct 6660 tctgaggaga tcaatttggg aagaaagtac cgatacaggt gtagaataaa tctctaaagg 6720 aaccgaacta agtaatcgat ctaggagctc ggtagtgctc actccctccg tccttttaac 6780 ttctaagtat tggtctgctg ctttagcaaa tctataacaa tcgtctccat tggcgtctgt 6840 agatatatcg tcaccatgta caacatactg acacccatat cttctcatcc attccaaatc 6900 aaacacatat ggtgcagagg gtaccacttc atcgacccat ttacaagtgt tagcagataa 6960 acaacgctcc tcaagagtca taacaggcgg tcccttgttt agggtaattt cttcatccga 7020 atgtatacca ataacaagcg tttcgcccaa ctgcttagct tgaagaatgg cattactatg 7080 acctatagag tgttaggtga ttagatatac tagagataat tgatagaaaa gtcctaccat 7140 aatggaagaa atccatgcac ccgtctaacc aaagacgatg ttttatattg gaagaagatg 7200 ccatgttatt ggatcaaaaa gataaagcta aaccaatatt atttcttccc tcaatatgaa 7260 tctgagaaat gtctttgtaa acctctatta gttaaagcac aatcataaaa atcgtttccg 7320 gtgatattca tttgaacacc atctacaatg atttatagag cctttaatga acctttagta 7380 ctaactaata attaatcaaa cggctcttct tttagctaat aacttacagc ttaaatttag 7440 taaaagtgtc gtagattaag tttcctgaat ccacgagtgt tttggtatac gttacttgac 7500 atgtgcacac cactcaacaa catcaataaa ttcagcaatt gattgattta atagtggttt 7560 atgctttatt tcattctttc aaaaacagtg ttatgcttgt tttagttatt ggggattttc 7620 atatcccaga ccgagctcct aagctctctg agaaggtaag aacataaaag ggataatgga 7680 attgtttata attgttagtt tatgttaaat gctaatttaa atattaaatg aagtttcgac 7740 aacttctaat tcccggaaaa atcagtcaaa tcatatgctt gggaaaccta actagcacaa 7800 gtgtatatga atatttgaag catgtttgtt ctgatttgaa gctagttaaa ggtgcttttg 7860 atattagcag taaggctcca atcgccggga aaataactct tggttctttt aaaatcgggt 7920 acacaaacgg tcacttggta gtacctcagg acagtccaga ggcactaagt attttagctc 7980 gagaaatgga cgctgatatc cttttgtttg gaggcacaca taaatttgca gcatatgaac 8040 ttgacggctg tttttttgtt aaccctggat cagctacagg tgcacctaat gtttctgctg 8100 tagaagatga tgaaaaaatc gttccaagct ttgttttaat ggatgttcaa ggagcagttt 8160 taatacttta tgtttatagg atttttgatg gagaggtccg ggttgaaaaa atgcagtaca 8220 gaaaaccaga ataatctcat gaaatatacg attgaaccac ggaatatgcg gtcttttcat 8280 cgtaaagaag tgttaaatga taattagatg tttttctgtt tattatagca taatccgtat 8340 cttaatttac cgagtatgta gactaccgaa aagtatgtgc tttccttact tgctttttta 8400 aaatgaaaga aatgtttgaa ggttaaattt atgcgctgac tttatccact tttctttgtc 8460 ggcctttcgc gtcaaatatt gttgaacatg ctatcgtttg tcctgatcga tatgtataaa 8520 taaaatcgta gtcaaggttg atttgtaaag caggtttgta aatctttttt aataaatata 8580 tcatatgaaa aatagatgcg ttagtacttg aaaagtacga ttatattcca gtgtcagtta 8640 gagatttaaa acaatataat ctcatcaacc tcagcatcaa atgcagcgag tgttttgatt 8700 atgctttctg tcatagtttt tctgtgataa tacgcagaat ctcttgtgat agagtccttt 8760 gtttgggtat tcttgatgtt tgaaactaac cgttcatctg gaacatgttt aacagtttca 8820 tttaaaaata aattggagcc cgtcctcatg caagacttcg gggtcgacgt tgctacaggt 8880 ttaagtttgt aaaataactc gagatcaaat tttaaaatgt ttaagccttc gtaaccattt 8940 acggggaaat cgtcagcagt ttttgtctca ggtgtcttaa ttattgaaaa atcagatgga 9000 agaatgtttg aaaaggcttg attttgatga attggtaatg tttgattagt tttgtcttgt 9060 aaagctggac gtgtcgaatt cttttttttt gaatttgata ttttaggatt cttgtttttt 9120 tttattaatt tatactctaa ttcgttttca ttatttatag ccataaatgc aatctattgt 9180 tttttttcgc ttaatgtttt atatgattaa tgcggttttg tttacatttt taccaatggg 9240 aaaacctaat gttcgaggtc tactagctga atttacgaat aacaaatctt aatgtttttt 9300 cgttgagttt acttagccta agtgaaacca caaggctgct gttaaaactt ttaaaggaaa 9360 accaaggtag tgtgacttta agataataaa ggattcaatc aagcatcgct aatccttttt 9420 gattccacag taaacaaaat atgttatggt gattataagt attaacttag attatataat 9480 taatggctaa ttaatataaa gttttgattt aatgtcttta agtgtgcaat ccatcgtaaa 9540 catcattgtc tatttataat aaggatttct catcatctgc attgaaaatc aaaacaactt 9600 aggaaacgca acattaagta attagaaatt tggttatgca atgtgtacta aacggcttgt 9660 aacttaaaag gagcttaacg tcgaacattg tgagtctcca aaaaacatag tttttttagc 9720 aaagcagtaa atatttgacg ttaaaatact tgacagataa tattaacatc aaatgaatct 9780 tatcatttct aaaagctttg cagtagttgc tttgcattcc ctgaatttcg ttttacattc 9840 actgcgcttt cttaaaatat ggtatgctgg aaatttgatt ccaaccacta acaaacaaaa 9900 atcatagata ttgctaaaaa ttaaacgatt ggcaagatgg atattcggcc agctcgtata 9960 agtgacctta ctgggatgca gaactgcaac ttacataact tgcctgaaaa ttatcagtta 10020 aaatattgta agttcaattc attgtaattc ttgctgcacg gcaatgaact tccagtatta 10080 aaacaatgat tcttattttc taatttaatg tagaccttta tcatgctatt tcttggccta 10140 tgctttctta tgttgctact gatccgaaag gacgtgtcgt aggatatgtt cttgcaaaaa 10200 tggaagaaga gcctaaggat gggatccctc atggtcatat cacaagtgtc tcagtaatgc 10260 gctcctatcg tcatctagga cttgctaaac gtctcatggt tcaaagtcgt aagtgttaat 10320 tgagagcgaa gtagattacg gatatatcca aggaggagct agagggaaat cttaagcttt 10380 tttgcagttg ttatcgatga ttattccaat atgtatatat tttattttgt gcaagacttg 10440 gtctgctaat actttgaatt gttcatttgg tgagttggtt ttttccttgc aacaattcat 10500 tttttttacc taatttgttt tcgacaatgt ttccttcctg ctgattcctt gatattttcg 10560 gtccattcct taaacaaaat ttttttaaaa aaagtaaaag atactaacta cttaaatgaa 10620 cagaaagagc catggtcgaa gtttatggcg ccaaatatat gagtcttcat gttcgtaaaa 10680 gcaacagagc tgctattcat ctttatcgtg atactttgca atttgagtat gtttttactc 10740 gccatcattg aagagattct aacattattt tagcgttcaa gggattgaaa gcaaatatta 10800 tgctgatggt gaagatgctt atgctatgca gtaagtactt tgttgtaaaa actaggttgg 10860 ggatggttgc atggatcgtt taatgagtat tctttccaaa aactatatac aatctttgtg 10920 acaatcgttc tttctttagt ttggtcaact tctgtataat tacctacgtt gtttcagaca 10980 atatatgact gttcaacgtc atcacaacta tctaggttac taacaatttt tagcaaagat 11040 ttttctactt tgaaattcga tacaccagaa accaacgacg aactagcaaa aaccgttcaa 11100 tctcttgcat tgaacaacta ataaaatata taccgttatt tctaattagt gaattagggt 11160 gtagtgtacg atactgcagt tataacttcg tgatagcgta tttaacattt gattgtactc 11220 gcttactggt gtactaaata tatttcgaaa taactcttgt aatttcgagt ttttgtttat 11280 cacatctaac tgcctaatcg tgtcgtttgg tgttaggtag cccaacacct cgatagtcat 11340 actgtattac ttgtcaccaa tatccactgc atttttagac gaatacctat ttaagctgaa 11400 atgacttcta tagcaaaagc ttttgttgaa aaggcgatct caaacaatcc ggttactgtc 11460 tttagtaaat cgttctgtcc tttctgcaaa gcagccaaaa atactcttac aaagtactct 11520 gctccgtata aggcttatga gttagataaa ataggtaagt atggtattct tcatttgttt 11580 aagagctgaa gattcagttg atcgattgta aagtttcttg agttatgtct acataaatta 11640 agtatatgaa ataatagtct aattgggttt tcgaaacctc ataattgtgt aatgaaacta 11700 cgaaaatttt tgtttccttc catgatcttg agaaatagcg aaacatttca agttttttgt 11760 tctgcttttc atccttttta actaacttga tgttacacta gaaaatggat ctgacatcca 11820 aggtgtgttt agttaacaaa ctgattttat catatgctta cctgagcagc ttatttacat 11880 gaaaagacca aacagtctac agtacccagc atattctttc gcaaccaatt cattggaggt 11940 atgaacccaa atttgttttc cttgaccatt aatattctcg ttggtttttc tctgttgttt 12000 attactaata cattatataa aggcaattcc gatttgaaca aacttcgtag ctcaggcact 12060 ttgacgaaga tgatagcaga gcttaaggaa aacaaatctt caattttatg attatcttta 12120 ggatttatat agcgaacgac tttacaatat tattttttag ggaaacgaga taacgaactg 12180 aatgtgcagt tgcaaaacaa ttctattata acattaaagg tatctttatc ttcaatcagt 12240 ttctagtttc ctgctcactt tgaacagcaa gttttcttca gttgcaaaac acacagtgtg 12300 tgcttttttt tggaaaaagt tatttagcca gattactttt ctacttacta tataccaagt 12360 ttaatagtga aatcatttga cttcaatctc atcacctcta gtagtcgcca tgcattgatt 12420 gccacttggt aatataaatg acacaacaga agcgacctca cgaagacaca cacacagtac 12480 gtacaaagtg atgtactttt cctttgttca ctgaacccaa gtaatacaat tggtttttcg 12540 tatatattta tttatattat ttttcactga tcatgaataa cccgacttcc gacgatcgtt 12600 tacgcttcca acaaaaatgc cataaatcca tgctaaacac tggggcgata tttaaaaact 12660 gtaaattacg aaacggagat gttttgcaag aagtcactga aagcttaact gaagacagtg 12720 aattcaacta cattgtaaat gagtctcaga atgtttctac tcgtttaata ttttggaata 12780 aatggattta tattttgtgt gctaatactt catcaaatat cacagctaca aggattttcc 12840 gtttagatga tgatc 12855 //