ID SPAC1556 standard; DNA; FUN; 13936 BP. XX AC AL132984; XX SV AL132984.1 XX DT 15-NOV-1999 (Rel. 61, Created) DT 18-JAN-2001 (Rel. 66, Last updated, Version 2) XX DE S.pombe chromosome I cosmid c1556. XX KW 5'-AMP-activated, gamma subunit family; azr1; azr1 protein; CBS domain; KW coiled-coil; cytidine deaminase; DNA repair protein; FAD binding domain; KW phosphomannomutase; pmm1; rad50 homolog; KW succinate dehydrogenase flavoprotein subunit precursor. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-13936 RA Saunders D., Harris D., McDougall R.C., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (14-NOV-1999) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; Q09189; Q09189. DR GOA; Q09190; Q09190. DR GOA; Q9UTJ2; Q9UTJ2. DR GOA; Q9UTJ7; Q9UTJ7. DR SPTREMBL; Q9HFC0; Q9HFC0. DR SPTREMBL; Q9UTJ3; Q9UTJ3. DR SPTREMBL; Q9UTJ4; Q9UTJ4. DR SPTREMBL; Q9UTJ7; Q9UTJ7. DR SPTREMBL; Q9UTJ8; Q9UTJ8. DR SWISS-PROT; Q09189; AZR1_SCHPO. DR SWISS-PROT; Q09190; CDD_SCHPO. DR SWISS-PROT; Q10343; YL28_SCHPO. DR SWISS-PROT; Q9UTJ2; PMM_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c1556 is overlapped at the 3' end by cosmid c1F12, EMBL CC entry SPAC1F12, accession number Z69944. XX FH Key Location/Qualifiers FH FT source 1..13936 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c1556" FT /map="ICEN" FT CDS join(complement(1943..2065),complement(1810..1893), FT complement(1..1766)) FT /db_xref="SPTREMBL:Q9UTJ8" FT /label=SPAC1556.01c FT /note="SPAC1556.01c, len:657, SIMILARITY:Saccharomyces FT cerevisiae, RA50_YEAST, dna repair protein rad50, (1312 FT aa), fasta scores: opt: 1175, E():0, (33.7% identity in 667 FT aa)" FT /partial FT /gene="SPAC1556.01c" FT /gene="SPAP4C9.01c" FT /product="putative DNA repair protein, yeast rad50 homolog" FT /protein_id="CAB61212.1" FT /translation="MSCIDRMSIMGIRSFDNRSRESIQFFSPLTLIVGQNGSGKTTIIE FT CLKYATTGILPPNTKGGAFIHDPKICGEKEVLAQVKLAFRNTNQVKMICTRSLQLSVKK FT TTRQQKTLDGQLLILKDNERTTISNRCAELDSQVPLSLGVSKALLDYVIFCHQEESFWP FT LSEPANLKKRFDEIFESLRYAKALDQIKGLKRDQETQVKVDQATLTHYRSDKERAEKIE FT LRVHESLKRISCIRSKVEELDQEITETARLQDELFKSTEEYEQQMITIRHLESQSDIIN FT TTINDLKSQMTITDESSEDLEKLHSNFAEKVKEEQELYKSLEKKRSDLESLLKSRRELL FT EKLTGDLGKIQGEIESLEKLKVKKSTMINEIVHRYNINEINEEGIMTEVSKYASLVNKN FT YEISSGKLKERQVAVRARIEGIKAHEMFLNNRVSEINSSLEKQLTTQKELRSRFEILFP FT VKLQREDFTKDVEKSDLWIKSLRQEYESKNLLELLDKHQTALSSVENRLDEISEIVDSY FT HKYSGVRTKLQVFEENKTNKSAILANQLMTLKSSFSEVMSYELKDDDNYNEELDKLVED FT VRKKLQEKEEAESSLRSVRERLEIRISLSVQSINDLTENKKIKTKTLKSYSGTFASMIS FT EIKALESEIEENRKTLHSLQFGS" FT misc_feature complement(1767..1778) FT /note="ctaacctgttag, splice branch and acceptor" FT misc_feature complement(1804..1809) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(1894..1905) FT /note="ttaatctaaaag, splice branch and acceptor" FT misc_feature complement(1937..1942) FT /note="gtatgt, splice donor sequence" FT CDS join(complement(4557..4655),complement(2609..4435)) FT /db_xref="GOA:Q9UTJ7" FT /db_xref="SPTREMBL:Q9UTJ7" FT /label=SPAC1556.02c FT /note="SPAC1556.02c, len:641, SIMILARITY:Saccharomyces FT cerevisiae, DHSA_YEAST, succinate dehydrogenase FT [ubiquinone] flavoprotein subunit precursor(ec 1.3.5.1), FT (640 aa), fasta scores: opt: 3141, E():0, (71.2% identity FT in 643 aa)" FT /gene="SPAC1556.02c" FT /product="probable succinate dehydrogenase flavoprotein FT subunit precursor(ec 1.3.5.1)" FT /protein_id="CAB61213.1" FT /translation="MLRFRKVAPSLKNGGNLKLFSTSSTLKKIASSQPLRAKQVSTSES FT VKYPVIDHTYDAIVVGAGGAGLRATFGLAEAGFNTACITKLFPTRSHTVAAQGGINAAL FT GNMTKDDWRWHFYDTVKGSDWLGDQDAIHYMTKEAPKAVLELEHFGVPFSRTKEGKIYQ FT RAFGGQSLEYGKGGQAYRCAAVADRTGHSILHTLYGQSLKHNTNFFIEYFAMDLIMEGG FT ECRGVIAMNLEDGSIHRFRAHKTILATGGYGRAYFSCTSAHTCTGDGNAMVSRAGLPLQ FT DLEFVQFHPTGIYGAGCLITEGCRGEGGYLLNSKGERFMERYAPTAKDLASRDVVSRAM FT TVEIREGRGVGPEKDHCYLQLSHLPAEILKERLPGISETAAIFAGVDVTKEPIPVLPTV FT HYNMGGIPTRFTGEVLTIDENGKDKIVPGLYAAGEAACVSVHGGNRLGANSLLDIVVFG FT RACALHIKDTLEPNTPHKPLAADAGLDSLKFLDQIRTSQGPKHTSEIRLDMQKTMQRDV FT SVFRMEETLQEGVKNIARVDGTYKDIGIRDRGLIWNTDLVEALELRNLLTCAVQTANAA FT LNRKESRGAHAREDYPERDDKNWIKHTLTWQHKTGDPVTLKYRAVTRTTMDENEVKPVP FT PFKRVY" FT misc_feature complement(3086..4072) FT /note="Match to PF00890 FAD_binding_2, FAD binding domain FT Score 823.72" FT misc_feature complement(4436..4447) FT /note="ctaacaatgtag, splice branch and acceptor" FT misc_feature complement(4551..4556) FT /note="gtatgt, splice donor sequence" FT CDS join(5453..5889,5940..6369) FT /db_xref="GOA:Q09189" FT /db_xref="SWISS-PROT:Q09189" FT /label=azr1 FT /note="SPAC1556.03, len:288" FT /gene="azr1" FT /gene="SPAC1556.03" FT /product="azr1 protein" FT /protein_id="CAB61214.1" FT /translation="MNVTRLYFRVAGTKQFARYVHKYAAYSSTSFQKKKSHFPSPATLD FT HPDAGEDAFINLRNENYILNAVFDGVGGWANVGIDPSIFSWGLVREIKKVFNNSDEFQP FT SPLTLLSKAYAALKKSNTVEAGSSTACLTLFNCGNGKLHSLNLGDSGFLILRNGAIHYA FT SPAQVLQFNMPYQLAIYPRNYRSAENIGPKMGQATVHDLKDNDLVILATDGIFDNIEEK FT SILDIAGVVDFSSLSNVQKCLDDLAMRICRQAVLNSLDTKWESPFAKTAKSFGFKFQGG FT YDKIIYM" FT misc_feature 5890..5895 FT /note="gtacgt, splice donor sequence" FT misc_feature 5924..5939 FT /note="ctaactttatttcaag, splice branch and acceptor" FT CDS join(complement(7009..7147),complement(6895..6956), FT complement(6744..6826),complement(6602..6680), FT complement(6522..6560)) FT /db_xref="GOA:Q09190" FT /db_xref="SWISS-PROT:Q09190" FT /label=pcd1 FT /note="SPAC1556.04c, len:133" FT /gene="pcd1" FT /gene="SPAC1556.04c" FT /product="putative cytidine deaminase" FT /protein_id="CAB61215.1" FT /translation="MEKEDIEKLFQEVKKSLQYSYCPYSNFAVGACVVSDDKNTYIYGA FT NVENASYGNCICAERVAITKAVSMGYTKFMAIGVMSAKGRVTPCGICRQVIREFSKDIN FT VYMFHDDGGYDMKTIEELLPDSFGPDDLK" FT misc_feature complement(6561..6576) FT /note="ttaacatgattggcag, splice branch and acceptor" FT misc_feature complement(6596..6601) FT /note="gtatgc, splice donor sequence" FT misc_feature complement(6681..6699) FT /note="ctaacaaaacgttgttaag, splice branch and acceptor" FT misc_feature complement(6738..6743) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(6827..6845) FT /note="ctcacatcaaccttaaaag, splice branch and acceptor" FT misc_feature complement(6839..7084) FT /note="Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine FT and deoxycytidylate deaminase zinc-binding region," FT misc_feature complement(6889..6894) FT /note="gtaaga, splice donor sequence" FT misc_feature complement(6957..6972) FT /note="ctaacgtatcaaacag, splice branch and acceptor" FT misc_feature complement(7003..7008) FT /note="gtaaaa, splice donor sequence" FT CDS join(complement(7893..7926),complement(7843..7852), FT complement(7651..7798),complement(7457..7600)) FT /db_xref="SPTREMBL:Q9UTJ4" FT /label=SPAC1556.05c FT /note="SPAC1556.05c, len:111, SIMILARITY:Saccharomyces FT cerevisiae, YGC9_YEAST, hypothetical 14.4 kd protein in FT rpl30-cwh41 intergenic region., (120 aa), fasta scores: FT opt: 279, E():1.1e-09, (49.1% identity in 110 aa)" FT /note="second intron branch site deviates from consensus" FT /gene="SPAC1556.05c" FT /product="hypothetical coiled-coil protein" FT /protein_id="CAB61216.1" FT /translation="MVNGTKGVCVSGKPWKTEKKAYNRSGLADAQRTPYEKRMEQKRKL FT DEIKEREKELKREKEEQRAAHAEKIRTRRQAKADRERMELLQAKLHQKVIDRRRRREKR FT NKMLKER" FT misc_feature complement(7601..7615) FT /note="ctaattattcataag, splice branch and acceptor" FT misc_feature complement(7645..7650) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(7837..7842) FT /note="gtatgc, splice donor sequence" FT misc_feature complement(7853..7864) FT /note="ctaattctttag, splice branch and acceptor" FT misc_feature complement(7887..7892) FT /note="gtatgg, splice donor sequence" FT CDS join(8760..10796,10870..11163) FT /db_xref="SPTREMBL:Q9UTJ3" FT /label=meu1 FT /note="SPAC1556.06, len:776" FT /gene="SPAC1556.06" FT /gene="meu1" FT /gene="meu2" FT /product="meiotic expression upregulated gene" FT /protein_id="CAB61217.1" FT /translation="MSIPANVLMEISFQELTSKKSEEYERKRLNEIGDLLTPQKIEEVL FT NCKDTKQRNVSLEDIFQDFLNFIITKNQEMFSMDCNSICKSYVLKVAEEKIEKLLKENG FT TLKNEEKCLRMQIVAQEEYVAPLIQKLEIIEKKLDKSFRKNMEDELRITRLASENNVLI FT SRIDRTKRHFSELFTQKQMLQLQNENFKDDYEKIKEENKRLYKERKSFLSKIEKSACEI FT HDLKESDSFKDHEILRLKEERTAAMQAIDDISGTIETIKSDCYKVESENKGLINEVMDM FT RNFVQQLEQELYAFEDDYSRIQNDEELLKVGMIHLNKSENRTVEEMKIGDFGNTEEAKD FT VCVSDEDIHNVNIKQITTLIGKMSQVQIECKRLRKENLFLQSERTHLLRELEELRHLAT FT SAKEDFVKVEKLNKIIKDENENLKEYIRNNSLSFQATAGELTQCKQLPQPRITGNDQEN FT SHYTGAGNNCLELVGKENNCKNQYPQYFSNIDESNAFINNQCLELEALNRKNDLIRGEL FT DSLKEKNLVAQKQLKSANNTLHVRAKHIQILENTNQSLKKNLENGRAEFRLKEIALIDL FT ANQQIKNQDKTIHDLNTELCSLTLDYCNTAVERDTLRFRALEYLDHNKQTNPLPYHIVY FT MFSFETSPTVFQTSPEEDKENVNNIKISQPRNSLQTNGYIEGMANNVLDASFNVEDESH FT AISDSELGYFCEDQSNIYEVEDMRYYLFYTEEEKNMLPGFIVNARPANLDLFPCCYETT FT DKRSKHLKNMLNKKKLIKHIFHL" FT CDS join(10791..10796,10870..11163) FT /db_xref="SPTREMBL:Q9HFC0" FT /label=meu2 FT /note="SPAC1556.06, len:776" FT /gene="meu2" FT /gene="SPAC1556.06" FT /product="meiotic expression upregulated gene" FT /protein_id="CAC22717.1" FT /translation="MANNVLDASFNVEDESHAISDSELGYFCEDQSNIYEVEDMRYYLF FT YTEEEKNMLPGFIVNARPANLDLFPCCYETTDKRSKHLKNMLNKKKLIKHIFHL" FT misc_feature 10797..10802 FT /note="gtaagt, splice donor sequence" FT intron 10797..10869 FT /note="intron confirmed by mRNA" FT misc_feature 10850..10869 FT /note="ttaaccaaaacacaaaccag, splice branch and acceptor" FT CDS join(12053..12139,12372..13058) FT /db_xref="GOA:Q9UTJ2" FT /db_xref="SWISS-PROT:Q9UTJ2" FT /label=pmm1 FT /note="SPAC1556.07, len:257" FT /gene="pmm1" FT /gene="SPAC1556.07" FT /product="phosphomannomutase" FT /protein_id="CAB61218.1" FT /translation="MAVIPIEERKFPKTLVLFDVDGTLTPARLSVSPEMLETLQNLRKV FT VAIGFVGGSDLSKQQEQLSVNGENVIDSFDYAFAENGLTAYRYGQQLASQSFIAWLGEE FT KYQKLVNFCLHYIADLDIPVKRGTFIEFRNGMINISPVGRNANTEERNEFERFDKGRKI FT RATMVDVLREKFKDYGLTFSIGGQISFDVFPAGWDKTYCLQHVEKEGFDTIHFFGDKTY FT KGGNDYEIFVDPRTIGHSVTNPDDTIAELKKIFNI" FT misc_feature 12140..12145 FT /note="gtaagt, splice donor sequence" FT intron 12140..12371 FT /note="intron confirmed from EST" FT misc_feature 12358..12371 FT /note="ctaacattttaaag, splice branch and acceptor" FT CDS complement(13656..13936) FT /codon_start=3 FT /db_xref="SWISS-PROT:Q10343" FT /label=SPAC1556.08c FT /note="SPAC1556.08c, len:92, SIMILARITY:Saccharomyces FT cerevisiae, SNF4_YEAST, nuclear protein snf4, (322 aa), FT fasta scores: opt: 261, E():9.3e-13, (53.5% identity in 71 FT aa)" FT /partial FT /gene="SPAC1556.08c" FT /gene="SPAC1F12.01c" FT /product="yeast snf4 like protein possible involvement in FT derepression of glucose-repressed genes putative FT 5'-AMP-activated, gamma subunit family" FT /protein_id="CAB61219.1" FT /translation="DGDYSNLDLSVGEALLKRPANFDGVHTCRATDRLDGIFDAIKHSR FT VHRLFVVDENLKLEGILSLADILNYIIYDKTTTPGVPEQTDNFESAV" FT misc_feature complement(13722..13856) FT /note="Match to PF00571 CBS, CBS domain Score 34.01" FT misc_feature 13838..13936 FT /note="nominal overlap with cosmid SPAC1F12, EM:Z69944 S. FT pombe chromosome 1" XX SQ Sequence 13936 BP; 4510 A; 2585 C; 2449 G; 4392 T; 0 other; gatccaaatt gcaatgagtg aagggttttc ctattttctt ctatttcact ttccaaagct 60 ttaatttcag atatcataga agcgaaggtc ccactataag atttcaaagt tttagttttt 120 atcttcttat tctcggttaa atcattaata ctttgtacag ataacgaaat tctaatttca 180 agtctttccc tgacggaccg aagtgatgat tcggcctctt ctttttcttg taacttttta 240 cgtacatctt cgactagttt atccaattct tcattgtaat tatcatcatc ctttaattcg 300 taagacataa cttctgaaaa cgaacttttc aatgtcatca gttggttagc cagtatagca 360 gatttattgg ttttattctc ttcgaaaact tgtaacttgg tacgaactcc agagtattta 420 tggtatgaat cgacgatttc tgaaatttca tctaaacggt tttcaactga agacagagct 480 gtttgatgtt tgtcaagtaa ctccagcaaa tttttacttt catactcttg acgcaatgat 540 ttaatccaca aatccgattt ttcaacatct ttagtaaaat cttctcgctg taactttaca 600 ggaaaaagga tttcaaagcg tgagcgcaat tctttttgag ttgtgagttg tttttcaagt 660 gaagagttga tttccgaaac acgattatta aggaacatct cgtgagcttt aattccttcg 720 atgcgtgctc tcacggccac ctgtcgctct tttagtttac cactggaaat ctcataattt 780 ttatttacaa ggctagcgta tttagacacc tctgtcatga tcccttcttc atttatttca 840 ttaatattgt agcgatgaac aatttcgtta atcatagtcg atttttttac cttcaatttc 900 tccaagcttt ctatctctcc ttggatttta cccaaatctc cagtgagttt ttcaaggagt 960 tcccttcttg atttgaggag actttctaaa tcagaacgct tcttctctaa agatttgtaa 1020 agttcctgtt cctctttaac cttttcagca aaattcgaat gaagtttctc caaatcttca 1080 gaactttcgt cagttatagt catttgactt ttaaggtcgt tgatagtagt attaataatg 1140 tcactttgac tttccaaatg tctgattgta atcatttgtt gttcatattc ttcagtggat 1200 ttgaaaagct catcttgtag cctagccgtt tcagttatct cttggtcaag ctcttcgact 1260 ttagatcgga tacaggatat acgcttcaaa gattcatgta ccctcaattc aattttctcg 1320 gctctttctt tgtctgagcg gtaatgtgtc aatgtcgctt gatcgacctt cacttgagtt 1380 tcctggtcgc gctttaaacc ctttatttga tccagagcct ttgcatatcg caatgattca 1440 aatatctcat caaacctttt ttttaaatta gcaggctcac ttaatggcca gaagctctct 1500 tcctgatgac aaaaaatgac atagtctaat aaagctttac tcacacccaa gctgagcggt 1560 acttgagaat ctaattcggc acaacgattg ctaattgtag ttctttcatt gtctttcaat 1620 attagcaatt gtccgtccaa ggttttctgt tgtcgagtag tttttttaac agataattgt 1680 aatgatctgg tacagatcat cttaacttgg ttcgtatttc gaaacgccaa tttgacctga 1740 gcaaggacct ctttttcacc gcatatctaa caggttaggc taacgtaaac attaatttac 1800 tgcacttact tttggatcat gaatgaaggc tccacctttt gtatttgggg ggagtattcc 1860 tgttgttgcg tactttaagc attcaattat tgtcttttag attaacattt gtttaaatat 1920 gaaattaggc aatgtaacat acagtctttc cagacccatt ttgtcctact attagcgtta 1980 atggggagaa aaattgaatg ctttctcgtg aacgattgtc aaacgaccgt atgcccatga 2040 tggacattct gtcaatgcac gacattttaa attacttaaa ctgaacacac tttctttaat 2100 tttaaggatt tacaactgta tagtaaaata gatgcatcca gtgaccttca attttgcaat 2160 ataatagtag aagaaacaaa gaaattgtgt gtcagtagat gcaaagcgtt ttgttaatgt 2220 gttgtatcag tgctattata gagtttctat attataataa tcgtaattgt ccttaaggtg 2280 gcggactaga ttttattgag gatatgagca taaacagtta attattcaaa tagcgatgac 2340 cagtttgact gcccaaggat tacaaatact agtgggtttg aattgtcata gaaaagtatt 2400 attatgatta ttagcacaat taaatttgag ttattaatac ccaagctcca tttatcggta 2460 aaaactacat tctttatacc gatattttat aataaatcat attgattaaa taaagatgtt 2520 aattaaattc tggtcactta tttcatgaaa tcaatttaat gttattatca aatagcaaat 2580 cttaaactta agaaatgaac gaagctcact aataaacacg tttgaaagga ggcactggtt 2640 taacttcatt ctcatccata gtggttctgg tgacagcgcg atacttcaag gtgacagggt 2700 cgcctgtttt gtgttgccaa gtcaatgtat gcttgatcca attcttgtca tcacgctcag 2760 gatagtcttc acgagcatgg gcaccgcgag attctttgcg gttgagagct gcattagcag 2820 tttgcacagc acaagttaaa aggttacgta attcaagggc ttcaacaaga tcggtgttcc 2880 agattaaacc acggtccctg attccaatat ccttgtaagt gccgtcaaca cgagcaatgt 2940 tcttaacacc ttcttgaaga gtttcttcca tacggaaaac tgagacatca cgttgcatcg 3000 tcttttgcat atccaaacga atttcactgg tatgtttagg gccttgcgaa gtgcgaattt 3060 ggtccaaaaa ttttagagaa tccaatccgg catcagctgc aagcggttta tgaggggtat 3120 tgggttcaag cgtatcctta atatgtaaag cacaggcacg tccaaaaaca acaatgtcca 3180 gaagagagtt ggcaccaaga cggttacctc catggacaga tacacaagca gcttcaccag 3240 cagcatacaa tccaggaaca atcttatcct tcccattttc gtcaatagtg aggacttcac 3300 cggtgaaacg ggtaggaata ccacccatat tgtagtgaac tgtaggtaaa acggggatag 3360 gctctttagt aacatctaca ccagcaaaga tagcagcagt ttcggaaatg ccaggaagac 3420 gctctttcaa aatttcagcg gggaggtgag aaagctgcaa ataacaatga tccttttcag 3480 ggccaacacc acggccttca cgaatttcaa cagtcatagc acgagaaacg acatcacgag 3540 aagccaaatc cttagcggta ggagcatagc gttccataaa acgctcaccc ttgctgttca 3600 aaagataacc accttcacca cggcaacctt cagtaattaa acaaccagca ccatagatac 3660 cagtagggtg aaattgaaca aactcgagat cttgtagagg aagtccagca cgagaaacca 3720 tggcattacc atcaccagta caggtatgag ctgaggtgca agagaaatag gcacgtccat 3780 aaccaccagt agccaaaata gtcttgtgag cacggaatct gtgaatacta ccgtcttcca 3840 aattcatagc aatgacacca cgacattcac caccttccat gattaaatcc attgcaaaat 3900 actcaataaa aaagtttgtg ttatgtttaa gagattgccc gtaaagagtg tgcaagatag 3960 aatgtccagt acgatcggca acagcagcac agcgatatgc ctgtccacct ttaccatatt 4020 caagggattg accgccaaaa gcacgttgat aaatctttcc ctccttcgtt cttgaaaaag 4080 gtacaccaaa atgttccaac tccaaaactg ctttgggtgc ttctttagtc atgtaatgaa 4140 tagcatcttg atcacccaac caatctgatc ctttgacagt gtcatagaaa tgccagcgcc 4200 agtcatcttt tgtcatatta ccgagtgcag cgttgatacc accttgggca gcgacagtat 4260 gggacctcgt aggaaagagc ttagtaatac atgcagtatt aaagccggct tctgccaaac 4320 caaaagtagc acgaagaccg gcacctccgg cacctacaac gatagcatcg tatgtatggt 4380 caatgactgg atatttaacg gattctgatg ttgaaacttg ctttgctctt aaaggctaca 4440 ttgttagatt gtttagaaaa ctgttcatag agtagagaaa caaagaaggg ttgcttaaaa 4500 atcataaaat ttgcaccgct tccaaaaata agacgagtca ctaaaaaaaa acatacctgg 4560 cttgaagcta ttttttttaa agttgaagaa gtagaaaata gcttcagatt ccctccattt 4620 tttagacttg gagcgacttt tcgaaatctg agcattatat gtgttggatg tggtggaagg 4680 agaagctttg gtaattgggc atctcttaag gaagtacagc atcgttaagt gcggaagttt 4740 gaaataccgc ccttcttatt cgtcaactcc ataagcgaaa tctaatcaat actcttctat 4800 ttccgtgtct ttaactttaa cttacattat tggcttaacc cacatctcgg tttaatgaca 4860 caaactgctt caataccatc atcattcagc tcgttaagaa aagcagtttt agtactactc 4920 ggtgaaaacc caagaactac gtataaaata tatttttact attgctttgt gcctccaaac 4980 ttttccgata aaaattagct agctaaatct cgaggacaag acgcttagtt cttccagagt 5040 gttagtaaac aattgtgcaa gtgcattgaa gcaacagtca gtattttttt ttgttaatct 5100 caaacattta tatcgtgaaa tattaattaa actgctccta agttatgatt tatcaagatg 5160 ctcctcgctc actattatac cgcattacat gatagtttgg taaatatata aggactcttg 5220 gaagttcaat aatagtacag gcacttacta caaactcatc aatcatatcc ccaccgttta 5280 tttatataat tagatgggta tacaaaacta acatatcata caattctctt actttgagtc 5340 tgatatctgt ttttgtaagt cgtgttcata cacactttat aaagtgttga acagaaagca 5400 attgttataa cttcttagac agggtgatta aaacaatttc tatgatccct caatgaatgt 5460 tactcgtctt tactttcgtg tcgctggaac aaaacagttc gcccgatatg tgcacaaata 5520 tgctgcatat tcctctacga gctttcaaaa aaagaaatct catttcccat ctcctgctac 5580 gctcgatcac ccggatgccg gagaagacgc ttttataaat ttaaggaatg aaaactatat 5640 cttaaatgca gtatttgacg gagttggagg ctgggcgaat gtggggattg atccgtcaat 5700 atttagttgg ggattggttc gggaaataaa aaaagtcttt aacaattctg acgaattcca 5760 accaagtcct ctcactttac tttccaaagc atatgcagct ttgaagaaaa gtaacactgt 5820 tgaggctggc tcaagcactg cttgccttac attgttcaat tgcggaaacg gtaaacttca 5880 ttcattaaag tacgttattt gttcattggt tcataaattc ttactaactt tatttcaagc 5940 cttggtgact caggatttct tatccttaga aatggtgcta tccattatgc atcacctgcc 6000 caagtactcc aatttaatat gccatatcaa ttggctatat atcctaggaa ctatcgttcc 6060 gctgaaaaca ttgggcctaa aatgggacaa gcaactgtgc acgaccttaa agacaatgac 6120 ttggtaattt tagctaccga tggcatattt gataatatag aggaaaagtc gatcttagac 6180 atcgctggcg tcgttgattt tagctctctt tcgaatgttc agaaatgcct tgatgatttg 6240 gctatgcgca tttgtaggca agcagttttg aattcgttgg atacgaaatg ggaatctcca 6300 ttcgcaaaaa cggcaaagag ttttggtttc aagtttcaag gagggtacga taaaataatt 6360 tatatgtgaa aatatattaa caagcacatt aggaaagtgg atgatactac cattacatgt 6420 ttactgataa agtccaaaaa ttatgagtaa aattagtatc ttcttcgaac gaaatacgct 6480 tatattgaat tactttagtt cattaagggt ccttgaatcg ttcatttcaa atcatctgga 6540 ccaaaagagt caggaagtaa ctgccaatca tgttaatgac attcaagtaa cgcttgcata 6600 cctcttctat cgttttcata tcataacccc cgtcgtcatg aaacatataa acatttatat 6660 ccttcgaaaa ttcacgaatt cttaacaacg ttttgttagt aaattcaacg gaaggatttc 6720 tttttcctta actgtcaact tacacttgac gacaaatacc acagggcgta actcttccct 6780 tggcactcat cactccaata gccataaatt tagtgtaacc catgctcttt taaggttgat 6840 gtgagttata atggtcaaag cggtagcaac tcttcacgcg caacttaatc ttaccactgc 6900 ttttgtaatt gctactcgtt cggcacagat gcaattgcca tatgatgcgt tttcaactgt 6960 ttgatacgtt agatttcata ttttttgaat tcggtacaat ctttttacca ttagctccat 7020 aaatatatgt atttttatcg tcggatacta cgcatgcacc tactgcgaag ttggagtagg 7080 gacaatatga atattgtaaa ctctttttta cttcttgaaa taacttctca atatcttctt 7140 tttccatttt ttgagtgcga ctagatttat tttgtgaaaa aaaaataact ccgatgcaca 7200 aaaaaattgc agaatatata tacaacctac taaaacgata ttatctagca atgttggaag 7260 aaatgttgtg agctgagctc ccggtatatc ctcggggcaa cgaataccaa agcgtatcca 7320 ctattccgtt aactactatc attatttttc taatacaatg atgttattac gagttgaaga 7380 ttgaaactgt aaaagtgatc aatgttatac cacttcaaaa gaatattatt tttccaatta 7440 tgtaaccgaa ttccattcat cgctctttca acattttgtt acgcttctct ctgcgtcgcc 7500 gacgatctat caccttttgg tgaagtttag cttgcaacaa ttccattcgt tcacggtctg 7560 cttttgcttg acgacgggta cggatttttt cggcatgagc cttatgaata attagtaatg 7620 gatatgatac tactgataaa gaatacttac agcacgctgt tcttctttct ctcttttcaa 7680 ttccttttca cgctctttaa tctcatctaa cttccgcttt tgttccatac gcttttcata 7740 cggagttctt tgagcatcag caaggccact tctgttgtac gcctttttct cagttttcct 7800 aattgtttaa taaaagcttt ctcatactga taaaaagcat accatggttt tcctaaagaa 7860 ttagtactta ataaacttgc tcaattccat acctgaaaca catacaccct tagttccatt 7920 aaccattgtg tatctggttt ttggtacaaa atttcttcta aacctctatt gaaccatcgg 7980 tcaaactcat taaatttggt taacgtagtc tcgtttttac agtctaaatt atttcagtca 8040 gtaaactaat tcggttgtaa aattgtcttt tgtaaagtga taatcgccta atattgaaaa 8100 ccaaagttct aaaagatagc agtttatctt aacaaatgaa acgaaactag acataatgac 8160 tcctgccaac gagagtgttt tggggatttt ttttacaaaa ttgtcttgag acagcaaatc 8220 aaagatacct gaaatactta atactatttt tcatgctaat ttttgttctg ttttctactc 8280 gaaataaata tcctcggtaa agtgtttggc agtaggaaaa aatacacctt aaactttctg 8340 aggggttctc attgtttttt ttttaatatt ttactgatat ttcgattaat cgaattatgc 8400 gtgaacgaat acgtttatta acggttaaaa tacctgttgg cgtatgatca tacacaatcg 8460 aatgtttgtt gacacctgca catattgagg tgtttgttta taaatcacag gagcataagc 8520 gaatggattt gtcacttacc aaacagttct aacatattac cctcaaggaa aattttgctt 8580 taatttactt gtgttgaata atttggaatt ttttttagag cataatcgca taatacacaa 8640 aatctcgatt aagcataaac tcccagaacg ttaacatata accgaatctt ctaaactctt 8700 agtatatgag atatcagaaa taataaagga atttcttaaa taatataaag aaaagaaata 8760 tgtctatacc ggctaacgtt ctgatggaaa tatcatttca ggagctgaca tctaagaagt 8820 ccgaagaata tgaaagaaag agactcaacg agatcgggga tcttcttaca cctcagaaaa 8880 tagaagaagt tttgaactgc aaagatacta aacaacggaa tgtttcccta gaagatatct 8940 tccaggattt cttaaatttt ataattacga aaaaccagga aatgtttagt atggattgca 9000 attctatctg caagtcatat gtcttaaagg tagcagaaga aaaaatagaa aagctcttga 9060 aggaaaacgg gactctcaaa aatgaagaaa aatgcttgcg aatgcaaatt gtagcgcaag 9120 aagaatatgt agccccgttg attcaaaagt tagaaatcat tgaaaaaaaa ctggataaat 9180 cgtttagaaa gaatatggaa gatgaattac gaataacacg gttggcttca gaaaacaatg 9240 tattaatttc aaggattgac cgaacaaagc gtcatttttc tgagttgttc actcaaaaac 9300 aaatgctgca acttcagaac gagaatttta aagacgacta tgagaagata aaagaagaga 9360 acaaaagatt atataaagaa aggaaaagtt ttctctccaa gatcgaaaaa tcagcgtgcg 9420 aaattcatga tctcaaggag tctgatagtt tcaaagatca cgaaatatta aggctgaaag 9480 aggaaaggac tgctgctatg caagcaatag atgatattag tggaacaatt gaaactatta 9540 agagtgattg ttataaggtt gaaagtgaaa acaaaggctt aatcaatgaa gttatggata 9600 tgagaaactt tgttcaacag cttgaacaag agttgtatgc ctttgaggat gactatagcc 9660 gaatacaaaa tgacgaagag ttattgaagg ttggtatgat acatttaaat aaatccgaaa 9720 atcgtaccgt agaagaaatg aagattggtg attttggaaa tactgaagaa gcaaaagacg 9780 tttgcgtttc tgacgaagat atacacaatg ttaacataaa acaaatcact acgttaattg 9840 gaaagatgag ccaagtgcaa atagaatgta aaaggttaag aaaggaaaac ctctttttac 9900 agagtgaaag aactcaccta ctcagagaat tagaagaatt acgacatttg gctacttctg 9960 ctaaagaaga ttttgtaaaa gttgaaaaac taaacaaaat cattaaggac gaaaacgaaa 10020 acctcaagga atacatccga aacaacagtc tttcctttca agccactgcg ggtgaattaa 10080 ctcagtgtaa gcaattacca cagcctcgga ttactggtaa cgatcaagaa aattcacact 10140 acacaggagc aggtaataat tgccttgaat tagtaggaaa ggaaaacaat tgtaaaaacc 10200 aatatcctca atacttctca aatattgatg aatccaacgc atttataaat aatcagtgtc 10260 ttgagttaga ggctctgaac aggaaaaacg atttaattag aggagaacta gattcactca 10320 aggagaagaa tctcgttgcc caaaagcaat taaagtcggc taacaacacg cttcacgttc 10380 gggctaagca catccaaata ctcgaaaaca caaatcaatc tttaaaaaag aacctggaga 10440 atggaagagc agagtttagg ttgaaagaaa ttgcccttat tgatttagct aaccaacaga 10500 tcaaaaacca agacaagacg attcacgatt tgaataccga gctatgtagc ttaacactgg 10560 actattgcaa taccgcagtg gaacgagaca cactgcgctt ccgtgcttta gaatatttag 10620 atcataacaa acaaacaaac cctctgccat accacattgt ctacatgttt agcttcgaaa 10680 cctcgccaac tgtttttcaa acttctcctg aggaggataa agagaacgtc aacaatataa 10740 aaatttctca accgagaaac tcattgcaaa ccaatggata tattgaaggc atggctgtaa 10800 gtgttgattc ataaagcaat atttcaatag gatttcaaag aataagaact taaccaaaac 10860 acaaaccaga ataatgtttt agatgcctct tttaatgttg aagacgaatc ccatgccatt 10920 agcgatagtg aattgggcta tttttgcgag gatcaatcaa atatttacga agttgaagat 10980 atgcgttatt atttgtttta cactgaggag gaaaaaaata tgcttcccgg attcattgta 11040 aatgcaagac cggctaactt agatctattt ccttgttgtt atgaaaccac tgataagcga 11100 tcaaagcatc tcaaaaacat gttaaacaaa aaaaagctta tcaagcatat cttccattta 11160 taatcttgaa atggttagtc cgcataaaga taacagttga agaaagcatc ttggaattta 11220 agtacgcgtg gacttgtgct gccagactag aaattatggc ttttgtctga ctctaataaa 11280 tccaggatga ttaaacataa aaaccttgac ccaaatttct accagattag agagctagaa 11340 agattaaacc tgttattcat tgtcttttaa actatgaaac tctcattaaa atggtaatgg 11400 caaggacact ccgagagctg ttgcttcatc tacatctttc tctattaaat aaatatttta 11460 ataagattta ttggaataac aaagttacat gtgttttaaa tgttcggctt tttaataatt 11520 ggaacattga taatttacat ctagtaagcc attttcacgg agtacgagga attgtagagt 11580 tgcagaatgc cgtttcaatg tttaaaagtt taaaacaaaa tattgatttc ataccatttt 11640 catccatctt ataaaaatac tttttttaaa caccgcgggt tcacacgcgt ctattttcat 11700 tatacgttac gcgctacacg aaatagaaaa aaatgaagtt ttgataaaaa tatcttcaaa 11760 aacacatttt ttgaaatatt tttctgtgcg aatacgactt tctatgtaaa atcccgattg 11820 attaattcaa attcctacga cacaagggta cctgaaatca acatttatga tattgtagag 11880 ctaatataat ataccttcct atgaatgttt ttgctataaa attttgttgt aagagtgtct 11940 aatgctttga aggtagaagg gggcttattg tttaccttga tcgagggggc ttcatcgacg 12000 cgttaccacc ataccactac cagttgcact taccttcgac caaattctca aaatggcagt 12060 tatccctatt gaagagcgta aatttcctaa gaccctagtt ttatttgacg ttgatggaac 12120 gctcactcct gcacgtttgg taagtttaga ttattgcagt cgagctttct tggattcaat 12180 ctgaatagcc ggcttgtatc aaatttccta ttttccaatc acattctcta tggtcatcac 12240 cattatttaa tcagagatgg cttgaaagga agttttaatt atccaaaata tttcgggagc 12300 aagctattca tgctctatga cctagtttat ttctctttcc attttgtaat aacaagacta 12360 acattttaaa gagtgtctcc cctgaaatgc tcgaaacttt gcaaaatctt cgcaaggttg 12420 tcgctatcgg cttcgtaggc ggtagtgatt tgagcaagca acaagagcaa ctgagtgtca 12480 acggtgaaaa cgtaattgat tcttttgatt atgcgtttgc tgaaaacgga ttaactgctt 12540 atcgttatgg acagcaatta gctagtcagt cattcatcgc ctggttggga gaagaaaaat 12600 accaaaaact ggttaatttc tgcttacatt acattgctga tctggatatt cccgtgaagc 12660 gtggtacttt cattgaattc cgcaacggta tgatcaacat atctcctgta ggacgcaatg 12720 ccaatactga ggaacgcaat gaatttgaac gttttgataa gggtcgtaaa attcgcgcta 12780 ccatggtcga tgttcttcgc gaaaaattca aggattatgg attgacattt tccattggag 12840 gtcaaatctc ttttgatgtg ttccctgctg gttgggataa gacatattgc ttgcaacacg 12900 tagagaaaga gggatttgat acaattcact tttttggaga caagacatac aaaggcggca 12960 atgattatga aatttttgtc gaccctcgta ctatcggaca ttctgttact aatcctgacg 13020 ataccattgc tgaactcaag aaaattttta acatatagat gagtttgtag tgtgttgatt 13080 agatatgcgt ccctctctta tcattacgga aaaggttagc tttcttagtt gtaaataact 13140 acttcatatg ctcggcgagt gtgaagtttc ttgcacacaa ttgatctgtc atttaactcg 13200 tacatcttcc ataattattg gtagcatgga atgcgaagaa cattaaatta ttgtaatcta 13260 ctgccaacgc agcttttaat actcatacct gaacaatatg catatatgaa agaatattta 13320 caagaaaatt acacttacga tcggttaatt gatgcattcc tagaaaaatg cgaacttagt 13380 agctaatgaa aggcatgtgt tagttattta attagatagg cattagcata atggtacaag 13440 tcacatcata ttatatagac agaagttgta ataaccgaat taatactttt tgaaataaaa 13500 gaagcctcat tcgagtacac tgaattagat accacctcga gctgccatgc aaaaaaaaag 13560 aaacaactca acggtttaac ttcaaatatc atgagacttg gcaatgtttt caacagatta 13620 tgaatgcatt caggctgaag cgcacgagaa tcaaattata cggcagattc aaaattatca 13680 gtttgttcgg gaacgccggg cgtagtcgtt ttatcgtata ttatgtaatt taaaatatca 13740 gccaaagata aaataccttc gagcttcaag ttttcatcaa ccacgaaaag acgatgaacc 13800 ctggaatgct taatagcatc aaaaatacca tccaaacgat cagtagctcg acaagtgtgg 13860 acgccatcaa agttagctgg tcttttcaat aaagcctcgc ctacgctcaa gtctaaatta 13920 ctataatcac catctt 13936 //