ID SPAC13C5 standard; DNA; FUN; 16500 BP. XX AC Z50112; XX SV Z50112.1 XX DT 20-JUL-1995 (Rel. 44, Created) DT 29-OCT-1999 (Rel. 61, Last updated, Version 5) XX DE S.pombe chromosome I cosmid c13C5. XX KW cytoplasmic organisation; dna repair; nuclear fusion protein; KW phosphoacetylglucosamine mutase; phosphomannomutase phosphoserine; KW proteasome subunit; proteosome A-type subunit; rad32; tht1. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-16500 RA Devlin K., Churcher C.M., Barrell B.G., Rajandream M.A., Walsh S.V.; RT ; RL Submitted (18-JUL-1995) to the EMBL/GenBank/DDBJ databases. RL Schizosaccharomyces pombe chromosome I sequencing project, Sanger Centre, RL Hinxton Hall, Hinxton, Cambridge CB10 1RQ E-mail: barrell@sanger.ac.uk XX DR GOA; Q09682; Q09682. DR GOA; Q09683; Q09683. DR GOA; Q09684; Q09684. DR GOA; Q09687; Q09687. DR SWISS-PROT; Q09682; PSA4_SCHPO. DR SWISS-PROT; Q09683; RA32_SCHPO. DR SWISS-PROT; Q09684; THT1_SCHPO. DR SWISS-PROT; Q09685; YA12_SCHPO. DR SWISS-PROT; Q09686; YA14_SCHPO. DR SWISS-PROT; Q09687; AGM1_SCHPO. DR SWISS-PROT; Q09688; YA16_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites CC CDS are numbered using the following system eg SPAC5H10.01c. CC SP (S. pombe), A (chromosome 1), c5H10 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c13C5 is overlapped at the 5' end by cosmid c31A2 and CC at the 3' end by cosmid c24H6. XX FH Key Location/Qualifiers FH FT source 1..16500 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c13C5" FT /map="1L" FT misc_feature 1..664 FT /note="nominal overlap with cosmid SPAC31A2 S. pombe FT chromosome I" FT CDS complement(335..1081) FT /db_xref="GOA:Q09682" FT /db_xref="SWISS-PROT:Q09682" FT /label=SPA13C5.01c FT /note="SPA13C5.01c, len:248, SIMILARITY:Saccharomyces FT cerevisiae, PRC9_YEAST, proteasome component y13, (258 aa), FT fasta scores: opt: 985, E():0, (61.2% identity in 245 aa)" FT /product="proteasome component y13" FT /gene="SPA13C5.01c" FT /protein_id="CAA90452.1" FT /translation="MSRSYDSRTTIFSPEGRLYQVEYALEAINHAGVALGIVAKDGIVL FT AAEKKVTSKLLEQEESAEKLYHIGDNMLCAVAGLTADANILINYARRVGQQYLQTFNEE FT MPCEQLVRRVCDLKQGYTQYGGLRPFGVSFLYAGWDHIRGYQLFQSNPSGNYGSWQANS FT IGGNSTSVQSLMRQEYKDDINLDEASAMAVKFLSKTLDSNSLTHEKIEFATITKDTTKN FT KMVCKIWKSDEINEVLNKYQETQRQS" FT misc_feature complement(521..985) FT /note="Pfam match to entry proteasome PF00227, Proteasome A FT -type and B-type" FT misc_feature complement(1001..1069) FT /note="PS00388 Proteasome A-type subunits signature" FT CDS join(1888..1927,1964..2180,2222..3200) FT /db_xref="SWISS-PROT:Q09685" FT /label=SPAC13C5.02 FT /note="SPAC13C5.02, len:411" FT /gene="SPAC13C5.02" FT /product="hypothetical WW domain protein" FT /protein_id="CAA90453.1" FT /translation="MSQPLPPGWTEHKAPSGIPYYWNAELKKSTYQRPSFIEKNHSSSV FT TASQASLAFNTSEKLFVNENAEERKNSRDLRKQLPDRPKFKKRIPNNDSWVVVFTKKNR FT YFFHNLKSHESYWEPPLEISKDLKILRLPIRKQISKDSSQSQNVDSGKTNHEEIHESRH FT LQTEIEEPSGLEESSEESVLYSEEFYEKSDEEEDEEKSHSAEELEFGEEDIMYQLQQLD FT DETVSYDIQEQATNLSTDDARRVFTELLKDKNIGAYQPWELVYPKLLDDDRFYVLDSGE FT RRKEVFEEYCKSVVSTKKITRRKNTLSDFWTLLHSLPSTLLWPQFKRKYRKSSTLQIPG FT YSERDFEKLFREFQILRKQPMQDKLLNFKKLCKSKTVDPKNPDEFTESILNDTRYAVLT FT REELDSLACSSN" FT misc_feature join(1900..1927,1964..2025) FT /note="Match to PF00397 WW_rsp5_WWP, WW domain Score 41.98" FT misc_feature 1928..1933 FT /note="splice donor sequence, gtaaat" FT misc_feature 1953..1963 FT /note="splice branch and acceptor sequence, ctaactcatag" FT misc_feature 2181..2186 FT /note="splice donor sequence, gtatgt" FT misc_feature 2206..2221 FT /note="splice branch and acceptor sequence, ttaacttttttttta FT g" FT misc_feature 2235..2324 FT /note="Match to PF00397 WW_rsp5_WWP, WW domain Score 47.70" FT CDS join(3441..3801,3844..4448,4511..5176) FT /db_xref="GOA:Q09684" FT /db_xref="SWISS-PROT:Q09684" FT /label=tht1 FT /note="SPAC13C5.03; tht1; nuclear fusion protein, has FT different N term to D87337 which is frameshifted in FT upstream reg ion w.r.t Z50112, len: 543, possibly spliced FT to upstream SP AC13C5.03" FT /note="SPAC13C5.03, len:543" FT /gene="tht1" FT /gene="spac13c5.03" FT /product="nuclear fusion protein tht1" FT /protein_id="CAA90454.1" FT /translation="MKYSNVAFSEGLAGFDSLAHVYQALLKKSTCYQEVAATLISKCSL FT LNTELTIDNRIHSAIQMTLCDFERSQILAPSECVRGSQSECVSKLESTSTWWLSFTSHF FT HDVNHLCRLANLEMQKELSIEVNMNVTLVQKQFLEMVILHLRNFESVTDKMNQRIDKFD FT GKFNSVIENSFKDINFRVNQEIMGLVELQNHQQEGMVQQKEILSTIKQLKSEIFDINSF FT FANFIEESAGYSNSLIEKLNEKFTSENAIALSAIGKYTSEFSAFMEKRIKNLITTTEDS FT LQQSVQSNIDFVNSGFQPLYDLTIQLKEELQSLKRLSSEQQNLQHEQILQWKSDFLNVS FT KDHLKVLQQLRPLIDIVEKFMNVYFKGLSNIISSFAFIGFTLFATLSSLFFKVLKIHRR FT PIIVFGSLSIIFIHIYCFKITSWVNLYGWITCTIARTLSFIKLNIRTFYLTAFLCALLN FT FLRYLKYRNSKKDTELSLFLPAPEECNIYHNEHIQVQEDNYLCPIENSLIDLFGSENNK FT EKLGKQENVRFAFLNSESLEQSPWWD" FT misc_feature 3802..3807 FT /note="splice donor sequence, gtaaac" FT misc_feature 3828..3843 FT /note="splice branch and acceptor sequence, ctaacaatataacaa FT g" FT misc_feature 4449..4454 FT /note="splice donor sequence, gttagt" FT misc_feature 4494..4510 FT /note="splice branch and acceptor sequence, ctaacagtactgtat FT ag" FT CDS 5988..6734 FT /db_xref="SWISS-PROT:Q09686" FT /label=SPAC13C5.04 FT /note="SPAC13C5.04, len:248, SIMILARITY:Saccharomyces FT cerevisiae, Q12288, orf ylr126c., (251 aa), fasta scores: FT opt: 442, E():5.3e-22, (32.5% identity in 249 aa)" FT /gene="SPAC13C5.04" FT /product="hypothetical protein" FT /protein_id="CAA90455.1" FT /translation="MDYHIAILNADTPMVEITSAYGDYADMVKSLLQSGSEYYSTEWNL FT VTKTYEVYKNPNDYPQKEDFPNINAIIITGSKASATSDAPWIKKLISFVKDVLFKYPHI FT KIVGLCFGHQIVAKAAGVPIIQNPKGWEVSSTVVQLTENGEKFFGRKVININQMHQDMA FT VDVPEGFELLGSTEDCEFQIFYKPRQALTFQGHPEFSTEVVNTMVKVLRGTEVFTEQQK FT EEALKRSENPADNDFLAVSIVKFLLE" FT misc_RNA 7078..7159 FT /note="putative snoRNA Sp-snR40, complements Sp-18S-rRNA FT and modifies Gm1288 and Um1286. Yeast snR40 and snR55 FT homolog. (Todd Lowe)" FT CDS join(complement(9012..9061),complement(8886..8971), FT complement(7420..8840)) FT /db_xref="GOA:Q09687" FT /db_xref="SWISS-PROT:Q09687" FT /label=SPAC13C5.05c FT /note="SPAC13C5.05c, len:518, SIMILARITY:Homo sapiens, FT AAD55097, n-acetylglucosamine-phosphate mutase, (542 aa), FT fasta scores: opt: 1327, E():0, (45.0% identity in 516 aa)" FT /gene="SPAC13C5.05c" FT /product="n-acetylglucosamine-phosphate mutase" FT /protein_id="CAA90456.1" FT /translation="MTKNKKYSYGTAGFRTKASDLEAAVYSSGVAAALRSMELKGKTIG FT VMITASHNPVEDNGVKIIDADGGMLAMEWEDKCTQLANAPSKAEFDFLIKQFLTPTTCQ FT PKVIIGYDTRPSSPRLAELLKVCLDEMSASYIDYGYITTPQLHWLVRLINKSTAASFLE FT EGPPITEYYDTLTSAFSKIDPSMQDSPTVSRVVVDCANGVGSQPLKTVAGLVKDSLSIE FT LVNTDVRASELLNNGCGADFVKTKQSPPLALEGKIKPNQLYASIDGDADRLIFYYINQN FT RKFHLLDGDKISTALVGYLNILVKKSGMPFSLGVVQTAYANGASTEYLQDLGITTVFTP FT TGVKHLHKAAKEFDIGVYFEANGHGTVLFSDKALANLAHPFFTPSPVQAAAIEQLQSYS FT VLINQAIGDAISDLLATISVLNALHWDASAWSNTYKDLPNKLAKVKVSDRTIYKSTDAE FT RRLVSPDGLQEKIDALVAKYEKGRSFVRASGTEDVVRVYAEASTKQAADELCEKVCQLV FT L" FT misc_feature complement(8841..8857) FT /note="splice branch and acceptor sequence, ttaataataataaat FT ag" FT misc_feature complement(8879..8929) FT /note="Pfam match to entry PGM_PMM PF00408, Phosphoglucomut FT ase and phosphomannomutase phosphoserine" FT misc_feature complement(8880..8885) FT /note="splice donor sequence, gtatgt" FT misc_feature complement(8972..8986) FT /note="splice branch and acceptor sequence, ttaacttgatcaaag FT " FT misc_feature complement(9006..9011) FT /note="splice donor sequence, gtaagt" FT CDS join(complement(10734..10959),complement(10382..10689)) FT /db_xref="SWISS-PROT:Q09688" FT /label=SPAC13C5.06c FT /note="SPAC13C5.06c, len:177" FT /gene="SPAC13C5.06c" FT /product="hypothetical protein" FT /protein_id="CAA90457.1" FT /translation="MKGFVVISRFILTLFILITPGLAGVVNYAENSEWNVPKYGNVLDS FT NCQGQKPVTFFGSVTEHVSNSWWIKLYDYMMTFISGEKLCMQNVAYEFEDISLCMDVVG FT SKCIPTLQSTDIEKVVNSTSAYLENSESDLTLGCFQIQRFQEESTLYIRALKSSEPVSC FT DTVRCIHFNHIPYV" FT misc_feature complement(10690..10702) FT /note="splice branch and acceptor sequence, ctaattatatttag" FT misc_feature complement(10728..10733) FT /note="splice donor sequence, gtacgt" FT CDS join(12072..12239,12288..12793,12864..13438,13482..13665, FT 13711..14227) FT /db_xref="GOA:Q09683" FT /db_xref="SWISS-PROT:Q09683" FT /label=rad32 FT /note="SPAC13C5.07, len:649" FT /gene="rad32" FT /gene="SPAC13C5.07" FT /product="dna repair protein rad32" FT /protein_id="CAA90458.1" FT /translation="MPNDPSDMNNELHNENTIRILISSDPHVGYGEKDPVRGNDSFVSF FT NEILEIARERDVDMILLGGDIFHDNKPSRKALYQALRSLRLNCLGDKPCELELLSDTSL FT TTGDTAVCNINYLDPNINVAIPVFSIHGNHDDPSGDGRYSALDILQVTGLVNYFGRVPE FT NDNIVVSPILLQKGFTKLALYGISNVRDERLYHSFRENKVKFLRPDLYRDEWFNLLTVH FT QNHSAHTPTSYLPESFIQDFYDFVLWGHEHECLIDGSYNPTQKFTVVQPGSTIATSLSP FT GETAPKHCGILNITGKDFHLEKIRLRTVRPFIMKDIILSEVSSIPPMVENKKEVLTYLI FT SKVEEAITEANAQWYEAQGTVPVVENEKPPLPLIRLRVDYTGGYQTENPQRFSNRFVGR FT VANATDVVQFYLKKKYTRSKRNDGLYTSAVEDIKINSLRVESLVNEYLKTNRLECLPED FT SLGEAVVNFVEKDDRDAIKECVETQLNKQINLLVKKRVTEENLEQEISSIINDLPKIST FT TKRKDYEELPEEVSETSINIAEHTPVLKHTSSLLDHHSPLATSSSEHEMEATPSPALLK FT KTNKRRELPSSLTKKNTRTPQRSKEVKKVPARKLSQSTKKSDKNTQSTLLFYDPSSTTE FT AQYLDNEDDEILDD" FT misc_feature 12794..12799 FT /note="splice donor sequence, gtaagt" FT misc_feature 12851..12863 FT /note="splice branch and acceptor sequence, ctaatgctttaag" FT misc_feature 13439..13444 FT /note="splice donor sequence, gtaaga" FT misc_feature 13468..13481 FT /note="splice branch and acceptor sequence," FT misc_feature 13666..13671 FT /note="splice donor sequence, gtgagt" FT misc_feature 13692..13710 FT /note="splice branch and acceptor sequence, tactaaccgattaca FT ttag" FT misc_feature 15842..16500 FT /note="nominal overlap with c23E2, SPAC23E2 EM:Z68887 S. FT pombe chromosome 1" XX SQ Sequence 16500 BP; 5594 A; 2854 C; 2813 G; 5239 T; 0 other; ggaaatacta taattttaaa tatgccggaa tggtgtactc aagtagaaat tgacgttatg 60 aagggaatga gaaagaaagg tctaagtata aaagaaactt gaaaaaagcc ttttttaaaa 120 cggcataaga attcataaga taatgattta gcgtagataa aaagaaagca agcctatatt 180 gagacggaat aaggctcatg atggaactta gtttgcttca aattgtttac aaaaaccatg 240 agctaattac aaggagatta aagggtaacg acgaaagcta taaaaaacag ctatacactt 300 aaagtgtttt cccaatgaat tgagtaaggc aatattaaga ttgccgctgg gtctcttggt 360 acttattgag cacttcattt atttcatctg acttccatat tttgcaaacc attttgtttt 420 tcgtggtatc ctttgttatt gttgcaaatt caattttttc atgagttagg gagttactgt 480 ccaacgtttt actcaaaaat ttcacggcca tagcagaagc ctcatctaag tttatatcat 540 ccttatactc ctgtcgcatt aagctttgaa cactagtact atttcctccg atactatttg 600 cttgccagct tccgtaattt ccagatggat tagattggaa tagctgatat ccacgaatat 660 gatcccatcc agcatataag aatgaaacac cgaatggacg tagcccacca tactgtgtat 720 aaccttgttt gaggtcacaa acgcgacgaa ctaattgctc acaaggcatc tcttcattaa 780 aagtctgcaa gtattgttgc ccaacccttc tagcgtagtt aattaggatg tttgcatctg 840 cggtaagccc tgccacagca cataacatat tgtctcctat atgatataac ttttctgcgg 900 attcttcttg ttctaatagt ttgctggtaa ccttcttttc agcagctaaa acaattccat 960 ctttagctac aatccctaaa gcaacgccag catggttgat cgcttccaat gcatattcaa 1020 cctggtataa acgaccttca ggtgaaaaaa tagtcgtgcg agaatcgtag cttcttgaca 1080 taatgaattt ggttgatgac aagttcgaaa atgcgcgaag cactagatca cgaacattaa 1140 tgaggtctac cgaagtgcga ttaccacact tgctttattc tttatgtgct tactacacta 1200 ctataacagg actgactttt acctgtcttc taatacaatt aatctattat gatttaaatt 1260 agtatgttgt taatccgctt atttttacaa gctatgctgt acaacaaatg tctttataaa 1320 tgagagctat ttttacgata atcaatttac ctttagtact ttcatatcct caagatataa 1380 agttatcagt gtaggttgct aataattaaa atctgcttgt aaaaatattt gaaccagagg 1440 agtcaatact agtgtaaaaa tgtagctgct tacaaatact tccagcctgc cgtttaacga 1500 tttaccacga gttatgaatt gctcgtaaat ttatgcgggt tgttgtaaat tgacaatatt 1560 aaaattgaag ttctcgaaaa tgttttatta tattgtactt ggtagaccat ttcattaact 1620 tcttatttgt tctaaaggaa atacttggga agacgctacg tgcggtgctg ttatgaggtt 1680 tttgtagtat attcaataat gttaactaca cctatgaatt tatgcaattt atacagattt 1740 tttttaatag tttgtagaaa tttttttgta attgacataa ctattcagct ggattttgca 1800 aaactgttct atctattctc acacacacgc ccactgaata ctacctaaca tagtgtcgaa 1860 cttaacttct tgattgtaca tatcttaatg tcacagcctt tgcctcctgg atggactgaa 1920 cataaaggta aatttaatga gcagtttatt tgctaactca tagcacccag tgggattcct 1980 tattactgga atgccgagtt aaaaaaaagc acttaccagc gcccaagttt cattgagaaa 2040 aaccattcat cttctgttac tgcttcgcaa gcttctttgg cgtttaacac aagcgaaaag 2100 ctgtttgtta atgaaaatgc tgaagagcgc aaaaattctc gagatttgag gaaacaatta 2160 ccggacagac caaaattcaa gtatgtgagg cgtaaaattt tgttattaac ttttttttta 2220 gaaaaagaat tcctaataat gattcatggg tggttgtttt tactaagaaa aatcggtatt 2280 tctttcacaa tttaaaaagc catgaatcat attgggaacc tcctttggaa attagtaaag 2340 acttgaagat attacgtctt ccgatacgga agcaaatcag taaagattcc tcacagagtc 2400 agaacgttga tagtggtaaa accaaccacg aagaaataca tgaatctagg catttacaaa 2460 cagagattga agagccctct ggtttagaag aatcatcgga ggaatccgtt ttatattctg 2520 aagaatttta tgaaaaatct gatgaagaag aggatgagga aaaatcacac tccgctgaag 2580 agttggagtt tggtgaggaa gatattatgt atcaacttca acaattggat gatgaaacag 2640 tttcctatga tatacaggaa caagctacaa atttatctac tgatgatgct agaagagtat 2700 ttactgaact tttgaaggac aaaaacatcg gggcatacca accgtgggaa ctagtttatc 2760 caaagttatt agacgatgat cgtttttacg tattagattc gggagagaga cgaaaagagg 2820 tgtttgagga atattgcaag tcggtggttt ctaccaaaaa aattacgcgt agaaaaaata 2880 ccttatcgga tttttggact ttgcttcatt cacttccatc taccttgcta tggcctcaat 2940 ttaaacgtaa atatagaaag tcgtcgactc ttcaaattcc aggatattcg gaacgtgatt 3000 ttgagaaact tttccgtgag tttcagattc tacgaaaaca gcctatgcag gacaaactgt 3060 taaattttaa aaagctatgc aagtcaaaaa ctgtagatcc taaaaacccc gacgaattca 3120 cagaaagcat acttaatgac acacgatatg ccgtactgac gcgtgaagaa ctggattcct 3180 tggcttgttc aagtaattaa tgaatttttt attaaatagg tgcttagaga atttctcatt 3240 tattaattta tttggaaaaa aattattttt tttcgcgtac tcttttaagc aagtagtttg 3300 tcgacgggtg agtttctttg tttaccatct actacaatta tgaaatttca tccgacgcgt 3360 cctttgggtt atatttcgag ttttttatta ttatttcttt tttctttact agtgagtcta 3420 ccggagatgt agaatcattt atgaaatatt cgaatgtggc cttttccgag gggttagccg 3480 gttttgattc tttagctcac gtatatcaag cactcttgaa aaaatccact tgctatcagg 3540 aagttgctgc aactttaatt tccaaatgta gcttattgaa tactgagttg actatcgata 3600 atcgaattca ctcagccatt caaatgactc tttgcgattt tgaacggtct caaattttgg 3660 ctccttcaga atgcgttcgt ggctcgcaaa gtgaatgtgt atcgaagttg gagtcaactt 3720 ctacctggtg gctttcattc actagtcact ttcatgatgt aaatcactta tgccggttag 3780 caaatctgga aatgcaaaaa ggtaaacttt aaataaactc taacaaacta acaatataac 3840 aagaattatc aatcgaggtg aatatgaatg taactcttgt gcaaaagcaa tttttggaaa 3900 tggtaatttt gcatttgcga aactttgaga gcgtgacaga taaaatgaat caacgtattg 3960 ataagtttga tggaaaattt aattcagtta tcgaaaattc tttcaaagat atcaactttc 4020 gtgtcaacca agaaattatg ggcttagtcg aattgcaaaa ccatcaacag gaaggaatgg 4080 tacaacaaaa agaaatacta agtacaatca aacaactaaa atcggaaata tttgatataa 4140 actccttttt cgctaatttt attgaagaaa gtgctggtta ttccaatagt ttaattgaaa 4200 aattgaatga aaagtttacc tcagaaaatg caattgctct ttccgctatc ggcaaatata 4260 ccagtgagtt ctctgctttt atggaaaaaa ggataaaaaa tttaattact acaaccgagg 4320 attcattaca gcaatcagtg caatccaaca tcgattttgt taactcaggt tttcaaccgt 4380 tatacgatct tacaattcaa ttgaaagagg agcttcaatc attgaaacgt ttatcctctg 4440 agcaacaggt tagttttact taatggtttt tatattcatc gttattgctt tgtctaacag 4500 tactgtatag aatttgcaac acgaacagat acttcaatgg aagtcagact tcttaaatgt 4560 cagtaaagat caccttaagg tacttcaaca gttaaggcct cttattgaca ttgttgagaa 4620 gtttatgaat gtatatttta aaggattgtc caacattatt agcagttttg cttttatagg 4680 cttcacgctg ttcgctacct taagcagttt atttttcaaa gttttaaaaa tacatcgccg 4740 accgattatt gtattcggct ccttatcaat aatctttatt catatttact gctttaagat 4800 tacctcatgg gtgaatcttt acggatggat cacttgcact attgcgcgaa ctctctcgtt 4860 tattaaatta aatatccgta ctttctatct gacagcattt ttatgtgctt tattaaattt 4920 tctgcgatat ctaaaatacc gaaattccaa aaaagatacg gagctatctc ttttccttcc 4980 agcaccagag gagtgcaata tatatcataa tgaacatatt caagttcaag aagacaatta 5040 tctatgccca atagaaaact cgttaatcga cctctttggc tctgaaaata ataaggaaaa 5100 actgggcaaa caggaaaatg ttaggtttgc tttcctgaat agtgaaagtt tggagcaatc 5160 tccatggtgg gattagtcat ctttctaatt cgaattaata aattctacat cttaagaatc 5220 ttttttactc gttttcattc acatgacatc aaagcgtgat gtgaacgagc atttcgactt 5280 agagcaatta ccgatacctg tatgatatgg tagaaaattt taggcgcata aaaaatgtca 5340 acgtgtatga ctatgtttga gttaaaacaa ttgaagatta atccctatga aatacaaaac 5400 tccttgttca ttatttccta aagtggtgaa ctattactat caatatttag aggacattaa 5460 gtcattttca tgaacaatca tgcgatacat aaatctgaac acctgttcca tcaccttctt 5520 caacatcaat ttattcaact aattgaaatg gattaaactt actaaaaata tcttatattc 5580 aaactttttg caaatcgttc tctctgtcat caccttagca aaaaccttat tatactaagt 5640 aagaaaataa ccgaaaaagt cgaaggcaaa taattttctt cttaattgaa gtggtactaa 5700 aggtttttgt gatccaaacg attataatat gttacgtaac gttgacaaaa acagtagttt 5760 acgaaatggt ttatctagat tcttcagtga atgtgaaata ctagcttaac gcctgtcgtc 5820 aattgcttga ccatttatcc cgtttgttca ttcatgctac acacatgagg acataacgta 5880 attatagcgg ttagaactcg caaaattcct acatatatat actacccgtc tagttcatat 5940 tttttccaag gcttttattt atcaactaaa aagattttaa tttgaaaatg gattatcata 6000 ttgcgattct gaacgcagat acaccaatgg tagaaatcac cagcgcatac ggtgattatg 6060 cagatatggt taaatcgttg cttcaatcag gttccgaata ttattctaca gaatggaact 6120 tagttaccaa aacttacgag gtatataaga atccaaacga ttatcctcaa aaagaagatt 6180 ttccaaatat aaacgcaatc attataaccg gctccaaagc atctgcaaca agcgacgctc 6240 cttggataaa gaaattgata agctttgtga aagacgtttt atttaaatac ccacatatta 6300 aaattgtagg tctctgtttt ggtcatcaaa tcgttgccaa agctgccggc gttcctatta 6360 ttcaaaatcc taaaggatgg gaagtttctt ctactgttgt tcaacttact gaaaacgggg 6420 agaagttctt tggtagaaaa gtcatcaata ttaaccaaat gcatcaagac atggcagttg 6480 atgttcccga agggtttgag ctattgggtt ctactgaaga ttgtgaattt caaatatttt 6540 acaagcctcg acaggcacta acatttcaag gacatccaga gtttagcaca gaagttgtca 6600 atacgatggt aaaagttctc cgcggaactg aagtatttac cgaacagcaa aaagaagaag 6660 cattgaaacg ctcagaaaat ccagccgaca atgacttcct cgcggtatca attgttaaat 6720 ttcttttgga ataagttaaa tctgttatga caagagtgtt tgcttataat gtttctacac 6780 ttcttcccta cattacttat taacgcttta atgactttca ctagatatct tccactaaat 6840 gtctaatgat atatcagttt aaatcaatta aaaacttaaa cgattatata ctttattgta 6900 tatttgcatg acaaaaattg caatagcaaa atgaccgtcg gctttagaaa gacagtcacg 6960 tgcagaccta tttatttgta aactgaaaac cattacagta aattaaccaa actccaaata 7020 tgtttaaacc gtcaacttat tagttttggt aagtaaaaag aaaaagttta attttacttt 7080 aatgatgata cactgtctca tgcaccactc tcagacattt atttgtcagt gaagaggaac 7140 agacccttta tttctgaaag taaaaattgt tcaaaaaacg aatattattt ttaattttat 7200 aaattaaaat tttactaaca ttttcatcag ttctttgcaa ttttgcttac ttgtgattat 7260 tacttttaag catcacatgg ctctataatt agatagaata aagcacggtt ttaaagcatc 7320 actcaatgtt tttattattt taaacataac gtcaagcgat aaattttttg attatgtcgt 7380 aaacaaatga gtagtaattt cgaaaaggaa atttaacaat tataatacta gctgacaaac 7440 tttttcacaa agttcatctg ccgcttgttt tgtgctggcc tcagcgtaaa ctcgtacaac 7500 gtcttctgtt ccagatgctc taacaaatga tcttcccttt tcgtactttg caacaagtgc 7560 gtcaattttc tcttgtaatc catctgggct cacaagtctt cgttcagcat ctgtactttt 7620 atatattgtg cgatcggaaa ctttaacctt agctagtttg ttaggcaagt ccttataagt 7680 attgctccat gcactagcat cccaatgtaa tgcattaagt accgaaatcg tagcaagaag 7740 atcactaatt gcatcaccta tagcttggtt gatcaaaacg gaatagcttt gtaattgctc 7800 tatagcagcc gcttgaactg gtgaaggtgt aaagaaagga tgtgctaagt tagcaagcgc 7860 cttgtcgctg aacaaaacag taccatggcc atttgcctcg aagtagacac caatatcaaa 7920 ctctttggct gctttatgaa gatgtttaac accagtggga gtgaagacag tagtaatgcc 7980 caaatcttga agatactcag ttgaagcgcc attggcgtac gcggtttgga caacgcctaa 8040 agaaaaaggc ataccggact ttttaaccaa tatgttcaag tagccaacga gagcagtact 8100 aattttgtct ccatcaagaa gatgaaattt cctattttga tttatgtaat agaagatcag 8160 tcgatcggca tcaccatcaa tggaagcgta gagttgattt ggcttaattt ttccttcaag 8220 ggcaagcgga ggggactgtt tcgtctttac aaagtctgct ccacagccat tgttaagtaa 8280 ctcactggcc cgaacatctg tgttaacgag ttctatagaa aggctgtcct taacaaggcc 8340 cgctactgtt tttaagggtt gcgatcctac accatttgca cagtctacta caacgcgaga 8400 aaccgtaggg ctatcctgca ttgaaggatc tattttagaa aaggctgacg ttaatgtatc 8460 ataatactca gtaatgggtg gcccttcttc aagaaaagaa gctgcggtag atttgtttat 8520 caacctcacc agccaatgca actgtggtgt tgtaatatac ccataatcta tgtagcttgc 8580 agacatttca tccaagcata ccttcagtaa ctcagcgagt ctgggtgagg agggtctggt 8640 atcataacct ataataactt tgggctggca ggtagtagga gtcaaaaatt gcttgattaa 8700 aaaatcaaat tctgccttgg aaggggcgtt cgcaagttgt gtgcatttat cctcccattc 8760 catagcgagc ataccgccat cggcgtcaat gatcttcaca ccattatctt ccacaggatt 8820 atgagaagca gtaatcatta ctatttatta ttattaatca aatatttcta cttgactaca 8880 cataccgcca atagttttcc cttttagctc catgctacgc aaagctgctg caactccaga 8940 actataaaca gctgcttcca aatcactagc tctttgatca agttaatgaa agctgcatta 9000 tattaactta ctttgttcga aaaccagcag ttccatatga atattttttg ttcttggtca 9060 ttgtgttagt tgctgttagt aaataaagaa gcgagtttgt cacgcaataa gtaaattcag 9120 tcgaaaataa caactcagcc tctctgcatt tcgcttctgc agattgatag attttaaatt 9180 atttgatagc aattcgttta aaacctcgaa cgtgttttgg agctaaaagt actctgcaca 9240 attttatatc ctctcgtttt cttccaatgt ttacataaag cccatcatag taatgttttt 9300 atttcaaatt aggaaccgct gtttctaata caatttttaa gatttggctc agattaatca 9360 attgcggttt gcctaaagaa taaacgtaaa tgtttacact ttaagatttt atgctaaact 9420 caactaagat tgtttttaat cccagtttta aaaatttgtt tatgttgttt tgataaaaat 9480 agttgatagc ttattaattg taaggaaact acgtatcgaa aagctattaa ataaaacagt 9540 tttaattgac tttcaatgag ctgaatggac aagtaacctt tttaatatag ttttacggat 9600 ttctctatat tgtctttata gtcgcattag catgttctgt agaatttttg ggcaacaaac 9660 atgtcaacaa tagtttggat ttctcacttc ctgtactagt tagaatacac ttaagtattt 9720 cgactaagtg aacagactta catttcctaa gtttgtaata gcaattactc attctaaatt 9780 cacaagcaca taaatatctt gtattaagcg agaagagcaa tagagcgttt caacacattg 9840 tttaaattgc ggtttaaaca gcatacatgc taataacaag attttaaaac acatctggac 9900 aatttgcaag atcttattat gccaataaat tacgaaatac accaattaca atatactgat 9960 tcgagaatca cataaaaatt tttttgaagc ctgtatacta aagcaattca aacttatata 10020 ataaaaaggc tttcacattc cattcagaaa cgtaagtaaa aattaacggg ataaataata 10080 tcataaaaca cagcaaaaag cttgatctcc caagctcaca acaaggtaaa caaattatct 10140 ctagtttctg agtctaattt aaaatatcct tgcagtcttg ttgaccaaat gaactagctg 10200 ctgcaacaca acaacaatcc aaatttgttc agaaaatttt gtgaatacaa ctctataaaa 10260 gacaacataa atcgatgaaa acggactcat taatctttgc ggtatgccta ttcaaaaaaa 10320 aaaacttctc aattcattga accgttgtag ttgtaagtaa aaagcatgtc aaaagatcat 10380 tctatacgta aggaatatgg ttgaaatgaa tgcaacgcac tgtgtcgcat gaaacgggtt 10440 cagatgattt gagggccctg atatacaatg tgctttcttc ctgaaatctt tggatttgaa 10500 aacatcccaa agttaagtcg gactcggaat tttctaagta agcagatgtt gaattgacaa 10560 ctttctcaat atccgttgat tgcaaagttg gaatgcattt actgcctact acatccatac 10620 ataaagaaat atcttcaaat tcgtacgcaa cattctgcat gcacaacttt tcaccactaa 10680 taaaagtcac taaatataat tagccaattg gaatggatgt atcatcaacg tactcatata 10740 atcgtaaagt ttaatccacc aggaatttga aacatgttca gttacagatc caaaaaatgt 10800 aacaggtttc tgcccttgac agttagaatc taagacgttt ccgtacttag gaacattcca 10860 ttcactattt tctgcataat tgactacacc ggccaaaccg ggagtgataa gtatgaaaag 10920 tgtcaaaatg aatcgggaaa tgacaacaaa acccttcata agtgttgttt tcactcaaaa 10980 cttaaaaact tgcactcaaa tgttgaaaga aagcatggct aattccgttg tttttatatt 11040 gcttccgtta gagaaataac tttaggatta aacctaaccg agccggcaat gccgcttaca 11100 acgatgatat aaacattacg ctaaatactc attatatgat aaacaatgca gagagaatct 11160 taaaaagtcc aggtaaaccc ataacaatca atcgaaactc caaagtaatt ttgattaatt 11220 ctttcacggt acaaaaaacg ttcaaaaaca cagaatgtac ttctgcaaga aatcggatat 11280 aaccaaccaa tacaataagg ttatgtgatt taaatcagtt ttccaacatt aaccttactt 11340 tcatgaaagg caatattgct ttatgaccta aatttaaaga atccgaagtt gcgtattgta 11400 gcttcacatt tgcagcacca aatttaatat agcggatttt tcaaatggct tagaagttta 11460 ccaatggcag tattggtaca taaaatagat tttggtcaaa tttatttttg gagcacaaag 11520 taatgtaaga aacatcacat tcactaattt aaatctttgt tttagtagtt acacggcttt 11580 aaggtcctcg cattatcggt aggttttgat ttcaacggac caaaaaactt tccgtctacc 11640 gatcccttct tggttcaaag aaggatatag cccaagttag aaaacttttg ccatcaacct 11700 aaggaaacaa gtaacatgcg tcatatgtaa cagcaaaaat ccaaaagaag aaaccttcct 11760 agtaggctat gagtgtactt ttatcttctc aatcatgttg gcataggtca aataagttga 11820 ccagaataat tgtttaaaac cccatacaaa aatcgtgaga tttctttcgc cagcgctttg 11880 taggaaagta gtagcaattt gaacgatata ttcacaagac ttttaaagta ttgtattgat 11940 gtatccttac gttgccttaa aaatgcattg tatcgtataa ggtagtacat aattattcta 12000 aagctgtaaa aggtgtcgcg tcttcgtgaa gcagtcatct catatatgga gttttattta 12060 ctgcaattgc aatgccaaat gacccctcag atatgaataa tgaacttcat aatgaaaata 12120 ctattagaat cttaatatct tctgacccac atgtgggata tggggagaaa gatcctgttc 12180 gtggtaacga ttcctttgtt agtttcaacg aaattttaga aattgctcgt gaaagagatg 12240 taggcataat atgatagcta ttcacgttaa tttattaact ttcataggtg gatatgattt 12300 tgttaggcgg tgatatattt catgacaaca aaccgtcaag aaaggctttg tatcaagcac 12360 ttcgctcact cagattaaac tgtttaggag acaaaccatg tgaacttgag ctattaagtg 12420 acacatcctt aaccactggg gatacggctg tttgcaatat taattactta gatccgaaca 12480 tcaacgtggc tataccagtt ttctcaattc atggtaatca cgatgaccct tctggtgatg 12540 gtcgttatag tgctttggat attcttcaag taactggctt agtgaactac tttggtcgtg 12600 ttccagagaa tgataacatt gtggtgagtc caatattgct gcaaaaaggt ttcacaaaac 12660 ttgcattata cggaatttca aatgttcgag atgaaagact ttatcactct tttcgtgaaa 12720 ataaggttaa atttttacgt cctgatctat atcgggatga atggttcaac ttattgaccg 12780 tacatcaaaa tcagtaagtc tgaaaaaact ttatatattt ttttcttttc accattaagt 12840 atatttttta ctaatgcttt aagctctgcc catacaccaa cgagctattt acctgaaagc 12900 ttcatccaag atttctatga cttcgtgtta tggggacacg aacacgagtg tctgatagat 12960 ggcagctata atcctacaca aaaatttaca gtggtacaac caggatcaac tattgcaact 13020 tctttaagtc ctggtgaaac tgcacccaag cattgtggta tcttaaatat tactgggaaa 13080 gattttcatt tagagaagat tcgtttgcga acggttcggc catttataat gaaggacatt 13140 attctctcag aggtttcttc catcccccca atggtggaaa ataaaaagga agtattaacg 13200 tatttaatct caaaagttga agaggcaatt actgaagcaa atgcacaatg gtacgaagct 13260 caaggaaccg ttccagtggt tgaaaacgaa aagccacctc ttcctttaat tcggttacgt 13320 gtcgattata caggtggata ccaaacggaa aatccccagc ggttttctaa tagatttgtt 13380 ggcagggttg caaatgcaac agatgttgtc caattttatc ttaaaaaaaa atacactagt 13440 aagaaaattt tgattaccga atatttgcta acgaacttta gggtctaaaa gaaacgacgg 13500 cctatatact tccgcagtag aagatatcaa aattaactct cttcgagttg agtcattggt 13560 aaacgaatac ttaaaaacaa ataggctaga atgtcttcct gaagatagtc ttggtgaagc 13620 ggtggttaac tttgttgaaa aagacgacag agatgctatt aaagagtgag tttaattctt 13680 ttcatcgtac gtactaaccg attacattag atgcgtcgaa acacagctta ataaacaaat 13740 caacttattg gttaaaaaac gagttacgga ggaaaatctt gaacaagaaa taagctctat 13800 catcaatgat cttccaaaaa tttcaactac aaaacggaaa gattacgaag agttaccaga 13860 ggaggtatca gaaacttcta taaatattgc tgagcacaca cctgtactta aacataccag 13920 ctcactgttg gatcatcatt caccgttagc gacttcttcg agtgagcatg aaatggaagc 13980 aacaccttct ccagcacttt tgaaaaaaac taataagcga cgagaattac cgtcttcttt 14040 aacgaagaaa aataccagaa caccacaaag aagcaaagaa gtgaaaaaag taccagctcg 14100 taaattgtca caatcaacga aaaagagtga caaaaataca caatctacgc ttctatttta 14160 cgacccatcc agcaccacag aagcgcagta cttggataac gaggatgacg aaattttaga 14220 tgattgattg atcttatcaa atttttgttt aagtgtacct atatttggat actgtaatgt 14280 taagcccatt gttgtaggtt ctaatctggt caggcttctt tacctgatgt tcgtggatcg 14340 ctgccaaaat acaactaatt tagtaataga gttattaaat gataaagaac ctttgtggta 14400 caaataacat atccagagtg aattcatata tagtgtcgat actttaacta tggcccactg 14460 aattacgatc taccggtcca cgtggaatac tttggtcata acataacagg gagcctaatt 14520 tgtctctaca acgcgatgta acgtactcca ctttattgtc tccattcaaa aacttagcta 14580 cattagttgc tacactaaga gggcgtgact gcttacctct tcactacata taaatttaac 14640 tcatacacaa tagacgagat caagttttgc aagtttgaaa gaagactctg cttataatgt 14700 gagtcttgcc aaatcatgtt tgaacttgtt tggataaagg taagtgtttc atttgaagca 14760 gaaggattgt gtagaatgtt tcggttacga ggaaagtata tatgcaagga cgagaattag 14820 gtacttgaaa cattacatcg caactgtaat gttttatgaa aatactataa attaaccaat 14880 tgttcctact gagcaaatac ctgtaatggc tttctttact tttcaattcc aacttcttaa 14940 cttaaaagga aaagatacta acattggacg tttaggttct attttgctta atatagttag 15000 ttagttggaa cgcacacaaa gcgatagtgc gaaatatgta tggtaaagcg ttatgaatta 15060 gtactgtttg ataaaaacaa ggggggaaag gatgaggaaa aactgtaaat gatgaaatag 15120 taataaaaag tttatagcca cgattaaagg catgtaaact gatttggtat tgtctatgaa 15180 aatcataaaa ggaacgaaaa gccgttttac ttgtactatc atattagcaa aacaagaaaa 15240 agaatgagaa agtgagggaa atttttcatg caataaacaa catttaacta atttttgtac 15300 taaactcggt ccagccgatg gaagttgcta tcgaaggtga aacattcatc atctagcctt 15360 ccattaccat gtgtggttta gcgatcatac ggtcttgggc attaatggat ctttatctta 15420 tatgattcgt tagtggcgga tttacaatta tcttatcaga gacagtcata caaatcgaac 15480 cggggagacc atcccgtggc atctaatttc ttaaaaattt tggagctcca ttagttcatt 15540 ttgacaaatt tcacttgtca tggatactag ggtttgccta gctcacctaa aaatttagtg 15600 tagggttggc cgaaatgaaa caaaatttac caagtttgta acgagaagtg cgacctttgt 15660 tcgagaaaat tttagaacat ttgagtttga ttgttctcga aaataaatgt ccattcttta 15720 gttaactatt gttaaaaatt taatgtgaat cttactaatg atgaaacagt aaaagcatcc 15780 tatgtatcat caacgattta agtaaattga cgtgcgaata aaccgtagaa tattggataa 15840 agtgacagtt tgacggatcc atgcatcgag aagatgaaga cttattacat aaagttatga 15900 tgaaattgac ggatttcata aactgtgcaa gttagctttt ttaaaaaaaa aaaaaaaaaa 15960 aaaaaatatt attattgcgc gtatatttga aattgttttt ggtcagcaat gtagtagaat 16020 tcatcgtgag aaagaaactt aaattctata tttattttct aattaactga atttaattaa 16080 tgaattaatt gattaagtgt caaccaatgc gtaggctaga aataaaaaat tgaaactaaa 16140 aaatcgataa aataaaataa taaaaaatat gcgacagatg aatgaaataa tactttaaaa 16200 atataaaaac aaatgaaatc aataaaacta aataaaataa ataataaatt acattcaatg 16260 aaataaggta aagttaactc gactcaaaaa agtaaataag ttcataccat gatattctac 16320 gtacaatcaa tagacatcag taaagactat atccatgaga ctagttcgtg aacaatatgg 16380 gaatatcaaa ttcagatatg aaaagaacag tctttacaag ttaagttaat aagccatatg 16440 taatgaactc tacctaattt caaaacaacc aaagcatacg ttgaaatatt aaataagatc 16500 //