ID SPAC1399 standard; DNA; FUN; 17256 BP. XX AC AL512491; XX SV AL512491.1 XX DT 04-JAN-2001 (Rel. 66, Created) DT 04-JAN-2001 (Rel. 66, Last updated, Version 1) XX DE S.pombe chromosome II cosmid c1399. XX KW maltose fermentation; MFS drug transporter; purine permease; KW uracil permease uracil phosphoribosyltransferase. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-17256 RA Zimmermann W., Wambutt R., Wood V., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (01-JAN-2001) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk and Agowa GmbH, Glienicker Weg 185, 12489 Berlin, RL Germany XX DR GOA; Q10279; Q10279. DR GOA; Q9HE12; Q9HE12. DR GOA; Q9HE13; Q9HE13. DR GOA; Q9HE15; Q9HE15. DR GOA; Q9HE16; Q9HE16. DR SPTREMBL; Q9HE12; Q9HE12. DR SPTREMBL; Q9HE13; Q9HE13. DR SPTREMBL; Q9HE16; Q9HE16. DR SWISS-PROT; Q10279; FUR4_SCHPO. DR SWISS-PROT; Q9HE15; UPP2_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c1399 is overlapped at the 5' end by cosmid c1002, CC EMBL entry SPAC1002, accession number AL136078. XX FH Key Location/Qualifiers FH FT source 1..17256 FT /chromosome="II" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c1399" FT /map="IIL" FT misc_feature 1..219 FT /note="nominal overlap with SPAC1002 S. pombe chromosome 1" FT misc_feature complement(229..256) FT /note="polyA 28 bases" FT CDS join(899..1164,1282..2605) FT /db_xref="GOA:Q9HE16" FT /db_xref="SPTREMBL:Q9HE16" FT /label=SPAC1399.05c FT /note="SPAC1399.05c, len:530, SIMILARITY:Saccharomyces FT cerevisiae, Q06719, mutant mal2-8cp malp, (470 aa), fasta FT scores: opt: 154, E():0.014, (23.6% identity in 140 aa)" FT /gene="SPAC1399.05c" FT /product="putative involvement in maltose fermentation" FT /protein_id="CAC19742.1" FT /translation="MGEVERTRQSSSSLLTFKRKRALEACDSCRKQKTRCLAGSVEDEN FT RACLRCRSLNMDCSLADPNHFIRKVENDNMDAISANINSKLENRLKVLEKAISSITNSP FT IAGQISLKSEKDVFLQGLLSMDEIELLLEIFIERYGKRWLSVDYSASQYMELLYTKSHL FT MLATACLIALRHNPSLKARIYTDVLNIVDRLISEELLTTSPSLQFFEAVSMLTLYRPLR FT LSQKQDLWLLSGFALQHRTLSSTKGWFNGFAGSSATLTYLDIVPARTWNHLCHGHLVMC FT MGYRRHAMLDENTFDDCRNILTNTKANEFDGNILGMLSVYSMLYRMLRSPTLDLDYAIF FT QLEEWRKEWCHLWEQPEPQYSRIAYFYSYNVVYEASIQTATDGNDFANIPRYVSMVQSY FT ALKTIDAIFELSAYDMSRCSDHVLFHAGFASASLLRLIYAAKTKEVDTSIVQPKVLNDL FT VTKIWKWLLVISVDQYHLATKFANYLKEYQKTVNEGTAESTWFKGPLRPVSSTTLQALK FT PYNLGVATVERG" FT misc_feature 1165..1170 FT /note="gtatga, splice donor sequence" FT misc_feature 1252..1281 FT /note="ctaacaaatttactaaactgcttattatag, splice branch and FT acceptor" FT CDS 2933..3595 FT /db_xref="GOA:Q9HE15" FT /db_xref="SWISS-PROT:Q9HE15" FT /label=SPAC1399.04c FT /note="SPAC1399.04c, len:221, SIMILARITY:Toxoplasma FT gondii.toxoplasma gondii., UPP_TOXGO, uracil FT phosphoribosyltransferase, (244 aa), fasta scores: opt: FT 710, E():0, (52.9% identity in 210 aa)" FT /gene="SPAC1399.04c" FT /product="putative uracil phosphoribosyltransferase" FT /protein_id="CAC19743.1" FT /translation="MSIPLEQPENVVVLRQTMYLLSLMTILRDQQTGHSEFVRTANLII FT NMLMQEALSALPYKKCLIKTSSGGTYTGVQPARDICGVSILRAGESMEYGLAAACNYSV FT PVGKLLVQRDETTFEAKLMFCKLPKDAQDRLVLLLDPLLATGNSVILAIQTLINKGIPE FT ENIVFVNLIACNEGITNVFAKFPKLRMVTASIDPELNANKYVVPGCGDFGDRYFGTC" FT CDS complement(4248..5993) FT /db_xref="GOA:Q10279" FT /db_xref="SWISS-PROT:Q10279" FT /label=fur4 FT /note="SPAC1399.03, len:582" FT /gene="fur4" FT /gene="SPAC1399.03" FT /product="uracil permease" FT /protein_id="CAC19744.1" FT /translation="MESVDNNSFFSRIRNSNAYRKVKDFVILDHRPGMTMAERMLTNKD FT LYPVPPSKRLWGPWNFISFWLADAVNINTWMISATAIELGLNWWEAWICVWVGYLICGI FT LVATTGRPGAVYHISFPVLSRSSFGTWGSLWPILNRSVLACVWYGVQAWIGGECVVLMI FT RSIWPSFSHIPNTMAKSGTETYQWVGFFIFWLLSNIAIWFPVHQIRHLFTFKAIVAPPA FT AIAFLIWALVKAHGAGPVIHEPTKLGQYEHAWVVINGIVTCIDGFATLIVNNPDFARFA FT TTPGAVHWPQIITVPLAFGVTSLIGVLVSSASKAIYGTTLWDPTQLLASFLDHSNAHGV FT RAGVFFIAFGLCIAQLGVNIAANSVSAGNDLSALLPTVINVRRGGYIASIIALCMCPWN FT LLSSNNNFTTYLSSYSVFLSSFAGVIIADYYFVRKGLIRVAPLYSSSSSSPYYFWKGIN FT FRAFASYICGMLINIVGMAGSTGQKVPKVANTMFNLNYFLGITVACLSHIIICKIFPVT FT ECGEKMLSEVPEEADDYLLTLASEDSIDKDSTSEIYIDGLPTEKEVEKDDVLSITSKKL FT SGCFP" FT CDS complement(8433..10202) FT /db_xref="GOA:Q9HE13" FT /db_xref="SPTREMBL:Q9HE13" FT /label=SPAC1399.02 FT /note="SPAC1399.02, len:590, SIMILARITY:Schizosaccharomyces FT pombe, YAN6_SCHPO, hypothetical 63.5 kda protein c3h1.06c FT in chromosome i., (589 aa), fasta scores: opt: 3469, E():0, FT (89.0% identity in 589 aa)" FT /gene="SPAC1399.02" FT /product="MFS drug transporter of unknown specificity" FT /protein_id="CAC19745.1" FT /translation="MNPSTSPNRNLASPKSLQLYTTGSEVAWYPTALDEANEIKSINSK FT AFSFKNQDQIYGAGSLKSRFSTHEISSEKNDSPDFTLVLPSNRLYIVIPGLMLSIFLAA FT LDQTVITTAIPTIVANLDGGSSYSWIGTAYSLAETSILPFCGIMSEVVGRKIVLYTSIV FT LFLFGSAMCGAAQNMLWLVLCRAVQGIGGGGIMSLVTIVIADITPLQTRPYYTGCMGVT FT WGVASVMGPLIGGAISQNTTWRWIFFINLPTGGLSLALLIFFLNLVPKPTVSFCVFLRD FT FDFVGIVTITTGVVLFLLGLNIGSTTGHWAHANVLCYLIFGILCIAGFVVNELYTTRTR FT IIAPSAFQTLSLSSVMVTSFLHYYIMSTVTYYIPIYFQSIKGDGPLMSGVHTLSLAVVS FT SVVSAISGMGIGKLKNYRYPMIGGWIVLLAGTGSMIAIYYDTPIPRTMGFLALTAVGIG FT NLFQPNLIAIQASVPPALMATSCSAFMLLRNMGASVGISIGAVIYDQQLTTLLKGTEYS FT TGLSYSQIASIPSVSERNFVFNVYANAIRTIWIVNCPVAGVGMLLSFFTKQEKLSQSVT FT EYKEKDKGFKDAP" FT misc_feature complement(10203..14939) FT /note="low complexity gene free region with strand FT inversion (ie (G-C)/(G+C) inversion)" FT misc_feature 12550..12633 FT /note="low complexity sequnece around point of inflection" FT CDS 14939..16744 FT /db_xref="GOA:Q9HE12" FT /db_xref="SPTREMBL:Q9HE12" FT /label=SPAC1399.01c FT /note="SPAC1399.01c, len:602, SIMILARITY:Emericella FT nidulans, UAPC_EMENI, purine permease., (580 aa), fasta FT scores: opt: 2173, E():0, (56.4% identity in 560 aa)" FT /gene="SPAC1399.01c" FT /product="putative purine permease" FT /protein_id="CAC19746.1" FT /translation="MSESIQDQDHEKTTIIEKTRRFVLSIFTKDFWIGDYDYSFLLPAI FT PFTKQKPKSPPFFSLNAKVPVLLALLLGFQHALAMVGGVTSPPRIIAASANLTTEQTNY FT LVSAGLISSGIMTLIQIARVHIPKTKYYIGTGMLSVLGISFTSVSVAPKVLSQMYENGY FT CPKDENGTKLPCPDGYGAFLATACVCSLLEIFMSFIPPRILKRLFPPIVTGPVVLLIGT FT SLISSGLNDWAGGEGSCTGRPTEAEAPGYSLCPSDTSPHALGWGSAQFIGLGFSVFATI FT IIIERFGPPLMKTTSVVLGLVVGMIISAATGYWDHSIIDAAPVVTFNWVHTFRLRIYGP FT AVLPMLALYIVNMMEAIGDIGATSDVSMLEVDGPAFDARVQGGILGDGLASLIASLMTT FT TPLTTFAQNNGVISLTKCANRRAGFFCAVILFFMGLFAKFAAVFVAIPSPVLGGMTTFL FT FSSVAVSGIAIISQIPFNRRNRFILTASMTLGMGAILVPDWFTYFFEYSGPNKALVGFL FT DAITLVMENGFAIGAFISIFLNLILPYEFDPDLTNDSPGLSTTNGVNNGIVEVRGIDPN FT DSLSNTDTEYANENKKDEVDVDKVV" FT misc_feature 15143..16435 FT /note="Match to PF00860 xan_ur_permease, Xanthine/uracil FT permeases family Score 497.47" XX SQ Sequence 17256 BP; 5488 A; 3181 C; 3341 G; 5246 T; 0 other; agattctttt gcgaaaaagt tagcttggcg atacaagagt gatggtgtgt tcaatgacca 60 gcaaatgcaa aagctttaca attttaacga ttaataaaaa ttagtgagaa aagctttatg 120 taatcttgtt cttaaattaa ttcaacattg ctgaaactca caaattcttt tattgcaaat 180 atctgtcggc agtgttggat actgatgtaa gtggtgatca ccgatatgtt tttttttttt 240 tttttttttt ttttttgcca ggtgttttga ggggatacac tgaaacacta caattactta 300 ctcaactaca cctcctgaca taaaacaagc caactcagaa agcattgttc gcccgttccg 360 tttcaaacga gtatgcaaac ataaacttgc tgtattgcat ttttttccaa catattcgtt 420 ttagtcatca cttacccttc aatatgtatc agcgagtata gcatcgatta cttttcaaca 480 aatgactcat caataataaa ggattcaaca accgctatcg ctttgtttac catcgcaaaa 540 tttcgcatcg ctccgaatct ctttttttta actgtccgtg tcgtaaaccc gtccctgttc 600 ttacgccaac agtatcagat agacttcttt cggcagacga aaatccgagt aagcacctta 660 tcaatattac ggaggtatga gtccaaccca caaatttatt gatactacca ggtttctcta 720 gcgagctcta ctgattttaa ccgtaattac gctaatagtt gctccaaggt gcttttgccc 780 ggagaccaga atagataacc attgttaagg aaacctatat atttattgag cgagagtcgt 840 tgtctgatat aaattccttc tattacctac atggtggaga aatttcaagt aggaaagaat 900 gggcgaagtg gaacggacgc gtcagtcatc ctcgtctcta ttaacattta aaaggaaacg 960 tgctcttgaa gcgtgcgact cttgccgtaa gcaaaaaacg agatgcctgg caggttctgt 1020 tgaggatgaa aaccgcgcgt gcttaagatg ccgctctttg aacatggatt gtagcttggc 1080 tgatccaaat cactttatac gaaaagtgga aaatgacaat atggatgcta ttagcgcgaa 1140 tatcaactca aaactagaaa acaggtatga atatatttgt tttattctta agacttttta 1200 aaaacccatt cctcttactg tagtcttgtt gttgtaatac catctttcaa actaacaaat 1260 ttactaaact gcttattata gactcaaggt attggagaag gccatcagtt ctatcacaaa 1320 ttctcctatt gcaggccaga tttccctcaa atccgaaaaa gacgttttcc tccagggttt 1380 actctccatg gatgaaatcg aattgctctt ggaaattttt atagagcgct atggtaagcg 1440 ctggctctct gtcgactaca gtgcttccca gtacatggaa ctactataca caaaatcaca 1500 tttgatgctt gcaaccgctt gtctcattgc tttaagacac aatccctctc tgaaagctag 1560 gatttacacg gacgtactaa acatcgtgga ccgccttatc tcagaggaat tgctcactac 1620 ttcaccttcc ctacagtttt tcgaggctgt atctatgcta accctttatc gaccgcttcg 1680 gctttcccaa aaacaagatc tctggctcct cagcgggttt gctttgcaac acagaacgct 1740 ttcgagcacc aagggatggt tcaacggttt tgcgggatct agcgctacac taacttatct 1800 cgatatcgtt cccgcaagaa cgtggaatca cctctgccat ggtcatttgg ttatgtgcat 1860 gggatatcgt cgtcatgcta tgttggatga aaatactttt gatgattgtc gtaatatatt 1920 aacaaatact aaggctaatg aatttgacgg aaacattttg ggaatgctct ctgtatactc 1980 catgctatac agaatgctgc gatcccctac cctcgatttg gattatgcaa tatttcagct 2040 tgaagaatgg cgcaaggaat ggtgtcatct ttgggaacaa cccgagccgc aatattctcg 2100 gattgcctat ttttattcct acaatgtcgt ttacgaggcc agcatccaaa cagctacgga 2160 tggtaatgac tttgcgaaca taccgcggta tgttagcatg gtgcaaagtt atgcgctaaa 2220 aacaattgat gcaatttttg aattgtcagc ttacgatatg tctcgttgct ccgatcatgt 2280 cttgtttcac gcgggttttg catctgcaag tttactgcga ttgatttacg ctgcaaaaac 2340 aaaggaggta gacacttcta tcgtccagcc taaagttttg aatgaccttg taactaaaat 2400 atggaaatgg ttgcttgtta tcagtgtcga ccaatatcat ttggctacaa agtttgctaa 2460 ttacctgaag gaatatcaaa aaaccgttaa tgaaggcact gctgaaagca cctggtttaa 2520 aggaccactg cgacctgttt caagcactac gttacaagct cttaaaccgt acaaccttgg 2580 agtcgctact gtggaacgtg gctaatcttt gccccataga gcccgcgttt gtgcctcggt 2640 gcgatagcgc ggttgttccg caatagctta atcaaagacg gtcggaaatt ccgcggttga 2700 aaatcggctg taaagtgtct gaaaaaaact aaaaactggc gatctaaaag atataaagga 2760 agaattcttg gccctgaata gagaaaaaag tttccacatt tgactgttta cgaacttacc 2820 tctatcttac gaattttgta aaaaattcct tttgttacat caaccttttc ttatcgaatt 2880 tcagtttttt tttgaattga atcgttttgt taaattaaaa tttccatcca atatgtccat 2940 tcctcttgaa cagcccgaga atgtcgtggt tctccgtcag accatgtact tgttatcatt 3000 gatgactatt cttcgcgatc agcaaaccgg ccattcagag tttgtgcgca cagccaatct 3060 cattatcaac atgctaatgc aagaagcatt gagtgcttta ccttataaga aatgcttaat 3120 aaagactagt tccggcggca cctatactgg cgtccaacca gctagagata tatgcggcgt 3180 cagcatttta agagctggag agagtatgga atatggattg gccgctgctt gcaactactc 3240 agttcccgtc ggcaagttat tggtgcaaag agatgaaact acgtttgaag ctaaattgat 3300 gttctgcaag ttacccaagg atgcacagga tcgtttggtt ttgttgctag atcccttatt 3360 ggctacggga aattctgtaa ttctcgccat tcaaactctg atcaacaagg ggatcccaga 3420 agaaaacatt gtgtttgtta atctcattgc atgcaatgag gggattacta atgtctttgc 3480 taagtttccc aagcttagaa tggttacagc gtctattgat cccgaattga atgctaataa 3540 atacgttgtt cctggatgcg gtgatttcgg tgaccgctac tttggcactt gctagaatcg 3600 ttgatctttc atctcatcag tgtatatctc tttctgatcc attcattgta ttttaattac 3660 cctaattttt attcgttctc gttcatttcg atatattaac cttagatata atcaattgta 3720 acatctattt catcaaagcc ctgtacactg catatcctcg cgatttattt aatttattat 3780 actcaagtcc ataccgtgac attcgacaaa cctttaatta ataaacataa ttttacatcc 3840 attttttcac gagttatttc agtaatcttt aatctctgtt ttccaacatt ctgtgttcaa 3900 taaggcgtgt tatttccatt tgatgtttga tttttataga acatcctatg ttacttctgt 3960 aactattacc ataataaaga tatgtcgctt acttactttt gaagtcatcc ctttagtaga 4020 taaacagctt tatttagtgt aatatgaata cgcttactgt ctaaacgcaa caaatatgca 4080 taacctatta atacacttca ttcattaact agcaatacat tataaacaaa gatgatctaa 4140 aaaattttta tgacaaacta aaaacaaaaa ataatttaat aaagaacctt caataaacct 4200 tgaaaaatta ctattaagac gagatcaaac cacaaaaagt aatttaccta aggaaaacaa 4260 cccgataatt ttttgctcgt aatactgaga acgtcgtcct tctcaacctc cttctcagtg 4320 ggaagtccat caatataaat ttcagatgta ctgtccttgt cgatggagtc ttctgaggca 4380 agggtaagca aatagtcatc agcttcttcg ggaacctcag aaagcatttt ctcaccgcat 4440 tcggtaacag ggaagatttt gcaaatgatt atatgagata aacaggcgac ggtaataccc 4500 aaaaagtaat ttaaattaaa catggtatta gcaacttttg ggactttttg tccagttgaa 4560 ccagccatac caacaatatt gataagcata ccacaaatgt aagaagcaaa tgcccggaag 4620 ttgataccct tccaaaagta ataggggctg ctagaagagg aagagtataa aggagcaact 4680 ctaatcaagc ctttgcgcac gaaatagtag tcggcaatga taacgccagc aaatgaagac 4740 aaaaagacgg agtatgagga taaataagtt gtgaagttat tgtttgagct taataaattc 4800 catgggcaca tgcagagggc aataatagag gcgatgtaac caccacgacg aacattaatt 4860 acagtaggca agagagctga caaatcgtta cccgcagaaa ccgaattagc agcaatgttg 4920 acaccgagtt gagcgataca caaaccaaat gcgatgaaaa agacaccggc acgaacaccg 4980 tgggcgttag agtgatcgag gaaagaggca agcaattgag taggatccca aagagtcgtg 5040 ccataaatgg ctttggatgc agaactaaca agaacaccga ttagcgaagt tacaccaaag 5100 gcaaggggaa cggtgatgat ttgaggccag tgtacggcgc caggggtggt cgcaaagcgt 5160 gcaaaatcag gattattgac aataagagtc gcaaagccat caatacaggt tacaattcca 5220 ttaattacca cccaagcatg ttcatactga cctaattttg taggttcatg aataacagga 5280 ccggcgccgt gggctttaac gagcgcccaa attaggaaag caatggctgc aggaggagcg 5340 acaatggcct taaaagtgaa gaggtgacga atttgatgta ctggaaacca aatggcaata 5400 tttgaaagga gccaaaagat aaaaaagcca acccattggt atgtctccgt accacttttt 5460 gccatggtgt tagggatatg ggagaaagaa ggccaaattg agcgaatcat caaaacaaca 5520 cattcaccac caatccaagc ctgcacaccg taccagacgc atgccaggac actacgatta 5580 agaataggcc ataatgaacc ccatgtacca aaggaagaac gagaaagaac agggaatgaa 5640 atgtgatata ctgcaccagg gcgaccagta gttgcaacta aaataccgca aataagatag 5700 ccaacccaaa cgcaaatcca tgcctcccac cagttcaagc caagctcgat agcggtggca 5760 gaaatcatcc aagtgttgat gttgacagca tcagctaacc aaaaagaaat gaagttccaa 5820 ggcccccaaa ggcgcttgga aggaggaaca ggatatagat ccttgttagt caacattctc 5880 tcggccatag tcataccagg cctatgatcc aatataacaa aatccttgac ctttctatag 5940 gcattgctat ttctaattcg tgaaaaaaaa gaattattat ccacagactc catgatttaa 6000 caagattaat gtttcagacg ataagaaaaa acaaacgaca aaaatgagaa aacttttttc 6060 aagacttttg tagggaaaga aaagatgagc gaaattaatt aagtgacttt aaataacaga 6120 ttgaaatatt aaacgagctg agtgaattcg ttaatgaagg aaaaaacgtt cgtaaacaaa 6180 aaaaaagagc cgacaaaaaa aatggaggaa accaacaagt gccgtaaaat atttcacctt 6240 tacaaataat agcagttatg tagtattaaa aaatcctaca aaggtttgac aaaggccttg 6300 cactgtggct tgagtagaag aaaaagtgga atgttgaaat attttcagag caatctaaga 6360 ggtaacaatg accagaggta acagaaattt ctccacaata aaagtggcga gcaagcgatc 6420 tttggaaaaa agatgagtga aaagctgtgt gctattacaa aacagatcgt taaatgtttt 6480 attttatgtc gcctttcaat tccctcaatg ttaagcctat aaagtttgca aatatgtatt 6540 ttcttaggaa gaaacctttg tttatatgta gagaaaattt tttatttcgc agcgcaatca 6600 gaggagatag agatatcttt cgcgtgtaag tttaaatcca aaacgctaac taacttaatg 6660 tgatagaaag ccaaccaaga ggctgaattc gtagattgta aggaatatgg gtattatcaa 6720 atgacgaaga ttagattacg ccgccgtcct taatataaat taatgataag tatatgaacg 6780 gatgcacaat agagataatt gataaaaact tggctgtgca gctgacctga ttctcaaaag 6840 ctttacttga ggtatagata aagcaacgaa ataagatatt ttcgctaagt ctgcaagtac 6900 gagaaatcgg gcgtaggctg atctatgtgc aaaacggtat gttaactcaa aagccaaaat 6960 ataggatgat agagtaaact cgtataatca atatgagtca aaaaaaagta tgaatggaat 7020 gcagggtaat gctttttgaa cgaacaatca aagaaatgaa ggaggaaaac agtgcgaatt 7080 gaagttaaca aacgaatgga aaagatgaat atcgacgata aaacaaacgt gtaatgccaa 7140 acaaaataga aaaaaatgaa atgtagaaaa actcaagaaa aagacagtgt ggactttggt 7200 aaaagctagt gatcaattaa tttccggatc caaaagaaac ggatagatgc aaacaatggt 7260 gtcgaaagta atgtcgactc ctacaagaaa ctaattagtc gtatcaaaaa ttgattttga 7320 taattgatga actttgctta ggttttatag ttaaactagt ttgcttggaa taggtcgata 7380 acgggtcgtc catttcgtct ttcaatataa caagctatta actatacttg ttttcattca 7440 ttttttttga taggaagctc accgcggcaa gcctttttgt agttttctgt tgatttcgtg 7500 gttttgttgt cgcatctatt tttttgagtt taaagttgtc aagataaaaa taaggccagc 7560 agttgaacac atcgcttaat cttatcagtt agtttttcac gtaagtaaaa agagttttcg 7620 acgaagattc tcaagtagtg ttttggtttt aaatttttct aaaaagaaat gatattagaa 7680 tgccgcgctt caaacggctt gttccaccaa aaaggtatag tctcagaaag tgcgatgatt 7740 tttttatcca tcgttacctt gttcgggaat gctgctacgg tctgcgcagt atgaaaacaa 7800 gtgaacaact gatcaatcag taaacataag aaatccttag ttgcgcagtt tagaaaagat 7860 gcaactatag caccttttgc aagcaaagca attgagctag gaagagataa atgattttat 7920 taaaaaatat taaaattaag taaagagtaa tccctacacc gtaaaccaaa ataaaaaaga 7980 aagagagagg gagaaaaact agtaaacatt gtttgcgaca gatcatggca gtaatcatga 8040 atttttaaca cttttaactc cttatggcga aagattttgt tttaacatgc aatacacttt 8100 agctccctgc ctctaatgcg aaatgaagaa atgtagtgta aaaacaaaaa gcagattaat 8160 tatttttgta aacttatcga agaaaaaatc attagcatac aacaatatca gaaaaaaatt 8220 ataacaatca agttcgatcc ttggttaaaa aaaaaaaaac cgaaacaaac attaaacact 8280 agtaatagaa aacacaatgt ttttaccagt caaacgtaga taaaaaaaat caagtaaata 8340 gacaatgacc ttattctgca atgtaaagaa aaataaattt aataaacagt tgttttggga 8400 ttcttcaaca aaagcttttt aaaaaataag tttcaaggag catctttaaa tcccttatcc 8460 ttttctttgt actccgtgac gctttgagat aatttctctt gctttgtaaa aaacgacaga 8520 agcattccta ctcctgcaac tggacaattt acaatccaga ttgtacgaat ggcattagca 8580 tagacattga atacaaagtt tctctcgctt acgctgggaa ttgaagcaat ttgagagtat 8640 gaaagccctg tagaatattc cgttcctttt agaagtgtcg taagttgctg atcataaatt 8700 accgctccta tcgatattcc cacagatgca cccatattcc ttagcagcat aaatgcggaa 8760 caagaagtcg ccatcaaagc aggaggtaca gaagcctgaa tagcaataag attgggttgg 8820 aacaggttgc caattccaac agctgtcaaa gccaagaatc ccatggtacg tggtataggt 8880 gtgtcatagt atattgcgat catactaccg gtaccagcta ataaaactat ccatcctcca 8940 atcattggat atcgataatt tttcaatttt cctattccca taccactaat ggcagaaaca 9000 actgaagata caactgccag agataaagta tgaacaccag acattaacgg accatcaccc 9060 ttgatgcttt gaaagtagat tggaatgtaa taagtcacag ttgacatgat ataataatgt 9120 aagaaggagg ttaccatcac agaagataaa gagagtgttt gaaacgccga gggagcaata 9180 attctagtgc gggtggtata aagttcattg acgacaaaac cggcaatgca aaggatacca 9240 aaaattaaat agcacaagac attggcatgg gcccaatgtc ctgttgtaga tccgatgttc 9300 aagccaagta aaaataacac aacaccagtc gtaatggtta caatgcccac aaagtcaaaa 9360 tcacgtaaaa acacgcaaaa cgaaactgta ggcttgggta caagattgag gaaaaaaatc 9420 aagagtgcaa gcgaaagacc accagtaggt agattaatga agaaaatcca gcgccatgta 9480 gtattctgtg aaattgcacc tccaattaaa ggacccataa cagaagcaac cccccaagtg 9540 actcccatac aacctgtgta ataaggtctg gtctgtaaag gagtaatgtc agctataacg 9600 attgtaacta aagacataat acccccaccg ccgatgccct gcacagcacg gcatagtaca 9660 agccaaagca tattttgggc agcaccacac atggcactac cgaagaggaa aagaacaatg 9720 gaagtataga ggacaatttt cctaccgact acttcactca taataccaca aaatggaagg 9780 atagatgttt ctgccaatga ataagcagta ccaatccacg aatacgatga accgccgtcg 9840 agatttgcta caatagtggg aatagccgta gtaatgacgg tttgatccaa ggcagccaag 9900 aaaatcgaca acataagtcc tggaataacg atgtacaatc gattggaggg caacacaagg 9960 gtgaaatcag gagaatcatt tttttcagac gagatttcat gggttgaaaa ccgagacttt 10020 agagaaccgg caccataaat ttgatcttga ttcttgaaag aaaaggcttt cgagtttata 10080 gactttattt cgtttgcttc atcaagcgca gttggatacc aagctacttc actgcctgtg 10140 gtatagagtt gtaaactctt tggggaggcc aaattacgat ttggagaagt agaaggattc 10200 attatgttta gtaactttat aacacaaata cactagggaa aaaaatccgt aaggaagagg 10260 gtgaatgcag ctaggagaaa aagagatatt gctaggaaaa aaaataatat tgaaggaaag 10320 aatataaata atcaagacaa cgaatgcaat tttaatgaaa caattgagta agtctgttac 10380 aatcagaaag gggggaaatt ttaactaaat cacagaataa aaacactact tccaggatgc 10440 ctagttttgg ttatggtaga gttttttttc tacttgcctg gaatgagtac gttttgagaa 10500 aacacataga taggaaatta taaggaagga aaattgacgc ggctttaagt gcacatattc 10560 ttagtttaaa aataagaaaa tatgcacatt aggccaagta attaccgagt aagcattttc 10620 atgtagaaaa tttgaatacg atctttagag gcaatattta tacaggattt ttctaacgat 10680 ggagcaaagg gagagcaaaa aaaaaaaagc cgcgctaata tccggaaaat agggacactg 10740 aaataaggag gttcgtcgag aaaagtctac agagtgtcta tgcataagaa aatgaaggga 10800 agtcgaaaaa agcaggcatt taaaaacgac gagaaaatga atgaagagta ttcctttttg 10860 agtgagcaaa aacgataatg ccgtgaagaa atgagcaaat ttaccaagat aagaggatat 10920 cgggatagtt gattaatatt gatatagatg taatgacagc aatgtatagt attataaatt 10980 tgtaatcttt taaaatgtga ggaatgtaga aataatcgta aacatgtatg atattataaa 11040 gggaaaatag gggatcggag taaacaagta agtgaatgaa gagagagagg gttgacaaaa 11100 tattgcatat caatggaatg gttaagcaaa cattgaaatg agtaagtaag caatgaaatg 11160 attaagaaaa gttttaatga gtcaaaagaa tgtttgtgga tcaacaaggt gcttttgagg 11220 gtcgataaag tgctcctttt aaggattttg taacaatatt acaataacgc ttctatatgt 11280 ctttagttgt acgtcttaca aaatctacag caacgatttt ttttatggat tgaaaagtgt 11340 gcgtatgtac aggcctgtaa tacaactctt tttttcaaag aattgcaatg tttattgtac 11400 atttgacttt ttagtctgac tggctgaaac agcatgtcgg aattgttaat ggcctttacc 11460 tactatttcc cactttagcg atgctttatt atacactatc ctaagatacc gagcaagatg 11520 cagaaatgca gaattccctg attagaagaa agagaagtga tgtttttaaa aaaaaaagtg 11580 aattctactc acaaaccttt tttttttttt tttgggggtt gtaagactgt agcatcatat 11640 tatttggaaa gatttcatca ctcacacggt aaggaaggaa ggaagaaggg aggtgggtat 11700 agcggaagta gccacctgca cacttggacg aaaggggatt gagtgaggaa aggcccgaat 11760 tttcgaaggt ttggaatttg tcgaatgtgc agaggaaaag tgcagctgaa taagcaaggt 11820 gaatctagga aggtgggcta gaagaaagtg aaaactaagc aagtgttttg ggtatttagt 11880 tttacaaagc aagctggaga ggtttagaga ggcagtaggt aactcaataa taatgcgacc 11940 ggggggaggg aggattaaaa aagatggata taataatttt tactcatttt gcggttcttt 12000 tgcatataaa gaactttaaa caccacgctg tgaaagacga gtgacattga taactggagt 12060 gaatgggatt gcatcggtct ttaatagata ttacgtttta aagcactaca agcactagtc 12120 aaagttgacc attactgaca agtagcgtag ataaacaacg taggtgggaa gggcacacta 12180 gagcgtatat aaggagaaag aacgcatgta aacgttaaag ggatatagtg tgatgcgctg 12240 cacaaacatt gattaattta tccaaccaaa aaccacgcat ggtagagcga tttgtttaca 12300 tttcaaggaa gcgctcgaat ggattgattt ttgatatttg aattatgaaa caaaaggatc 12360 ggttgtttga tgagagtaag attccgtgat tgaggaggtt tctagctttt ctaagtatgg 12420 taaaccagca attcccactt tgcatatcct tcgttggtcg gaaagagtgg gtgagggtgc 12480 ctttttcgtt tacgtgtgag cgatagatag gggaacgaaa gttcgcggac ttttttgtca 12540 gcaagtctcg ataagatagc gcagtgcagt gtaggcggta tggtggaagg gaggaagagt 12600 gtgtgtgaga gagagagaga gacggtatga gagaaggatg gaaaaaatgg agcagggaaa 12660 gcagaaacat cgttcgattt gaaacaaaag gaaaagtata aagagagaag aaagtaggaa 12720 agtaatgaga gtaagagcag taatagtaac ataggtattg ctggatacaa tgggatacaa 12780 tgggtagaat gttgatattg tagatgtaac tatatgtgta agtgtagctt gtcgcatagc 12840 aagtatagta agcaggctga cagaaacaca gacagataaa tacacaaata gacacaaaga 12900 ctatccatct acatcgtttc caacttcaac ttctgcaact gcaactccca cttcaatttc 12960 aatctcattt tcataatcgt tttcttgcat cgcctttgcc tttccccaat ctccctctct 13020 ctttaccctc ctctaccatc tttttcgtcg caaaaatcct tactcacaca ctctctttcc 13080 gcctctttat ttctccctcc gcctctttat ttctatcaac gctctcggcc ctctattatc 13140 gctctcgtcc taaagcgatt gactaagcta aaagtacttt gttcatccac tctatctagc 13200 ctgtccaatc cgtgctatat ctaccccgac aacctccctg acttgtcgtt tcttctttta 13260 cgcatcgccc aatgcctgta agctgcgtca acgatgatta gatagttttg tgttggacga 13320 aagcgccaaa cgaatcggat tggtttgagg tacaaggcga tgaatgctga gtggtggatt 13380 cggctgcgaa tacaaagaca aaacaaaatc ggcgtttgct cattgataat caatgctcct 13440 atgggtggtg agtgatgtga gatgttggaa tgggcaaatc gcatttgttc acccctgctt 13500 ttcctaagat tagttactaa gtatgtatta aaatttcctt gtatagcgga cttgccaaaa 13560 tgtaatcgcc gctattctgg aaaagaaagt agttcttgag agtgttgaat ttgtatttaa 13620 taaggcttat tgacacgatt tcattccaac gaattgcgct tcacaagcaa agcaaagcaa 13680 aggcaacagc aaaagcgaaa acaaaaacaa aaaagtaaat ccaagtcaag tcgagtccag 13740 taaagagtat tgtatccttt aggtataata cccttgttta attacaattt tcacttgttt 13800 aattacactc ttcacttgtt taattacact cttcacttgt ttaattacac ttcttcctct 13860 atcaagttag tgtttcgatt gctttcatct gaattgtttg gtaggtaaaa acaacgccta 13920 tttttttttt gtcgcaccat ccaaattact ttgtatcaat cccatcactc ctcgcagtgc 13980 tttgtctcgc ttttacagta ggatttttgc gttgtaccat atacttcacg aaattttgcg 14040 cttcattaaa ttgtctctct ctctattgac tctttgtgtg tgtgtctagc attttctgac 14100 tacttgtagt tgttatcctt tgctatcgcg ctctatctaa tcagctcatt tttatttatt 14160 tacatccatc actccttgtt gcaaggttag agatttgact agttccatcc ttcttcttaa 14220 tcactgaagt catttttgta cttgtcattc attccaactt gtttatctca agtcattcat 14280 ttattatcct ccctataaat tgactaggtt gttcccccct taacaattca ctcattctta 14340 aaacaaccca aagttactat agtagcgtat ccttgacata atctaaattg attgcgtcga 14400 aaaaagaaaa cactaaaaga gcaccttgtc gttttttttg ccttacacca aaaaaaaaac 14460 tctttgtata tctctgaaag aaaaagtttt gaagcaaacc ttttatttct tcactttttt 14520 tttacttact ctgtattctt ttattctctc aactctgcct tttcattaag cgctgtcgat 14580 agcataccct ctttgccata tcgcttcgtt tcaccttgtc tactcttctt ctactaaagg 14640 aaataaagtt ttttaatttt taatttgctc ttttcctttc tctttattta attggcttat 14700 tgttcgattc ctcttttgtt caattgtgga tttcttgggg tttcttattt actagctgat 14760 tgttctttgg tagttttaga ggtaattgtt tttttcctgt acgaactttt cttaaagttt 14820 gttgcgttga gatttccttt cgtcctaact tgtaatatct aattcttatt aatatctttt 14880 ctcttttttt tttcgttttc gtctcttctt attttttttt atctttaatt tttctacaat 14940 gtcggaatcc atccaagatc aagatcacga aaagactact attatcgaaa agactcgtcg 15000 ctttgtttta tccatcttta ccaaagactt ttggattggc gattatgatt attccttttt 15060 gctacctgcc atccctttca ccaaacaaaa gccaaaatct cccccttttt tctcgttaaa 15120 tgccaaagtc cctgtcttgt tggctttgct tttgggattc caacacgctt tagccatggt 15180 cggcggtgtc actagtcctc ctcgtattat tgctgcttct gccaatctta ctactgaaca 15240 aacaaattat ttggtctctg ctggcctcat cagtagtggt atcatgacac ttattcaaat 15300 tgcccgggtt catattccaa aaacaaaata ctatattggt acgggtatgc tttcggtgct 15360 aggtatttcc tttactagtg tcagtgttgc tcccaaagtt ctctctcaaa tgtacgaaaa 15420 tggctactgt ccaaaagatg agaacggcac aaaacttccc tgtccagatg gctatggtgc 15480 tttccttgca accgcttgcg tttgctctct cttagaaatc tttatgtctt tcattcctcc 15540 acgcattttg aagcgtctat ttcctcccat cgttactggc cccgtcgttt tacttatcgg 15600 tacttctctc atcagtagtg gtcttaatga ttgggccggt ggtgaaggct cttgtactgg 15660 tcgtcccact gaagctgaag ctcctggtta ttccttatgt ccttccgata cctctcctca 15720 tgctttaggt tggggtagtg cacaatttat tggtctcggt tttagcgtat tcgcaaccat 15780 cattatcatc gagcgctttg gtcctccact tatgaaaact acttcagttg ttttaggact 15840 tgttgttggt atgattattt ccgctgctac tggttattgg gatcattcta tcattgatgc 15900 tgctccggta gttaccttca attgggttca taccttccgt cttcgtatct atggtcctgc 15960 cgttcttcca atgcttgcac tgtacattgt aaacatgatg gaggcaatcg gcgatatagg 16020 tgccacgtct gatgtctcca tgctggaagt agatggccct gcctttgatg caagagttca 16080 gggtggtatt cttggtgatg gcctagcttc acttatcgct tctcttatga ctactacacc 16140 actgactact ttcgctcaaa acaacggtgt catcagtttg acaaagtgtg caaaccgtcg 16200 tgctggattc ttttgtgcgg taatcttatt ttttatgggt ttgttcgcta agtttgctgc 16260 tgtctttgtt gccattccgt ctcctgtctt aggtggaatg accacatttc tcttttcatc 16320 tgttgctgtc tctggtattg ctattatctc ccaaattccc tttaatcgtc gtaataggtt 16380 tattttaact gcctccatga ctttgggtat gggtgctatt ttggtcccag attggtttac 16440 ttatttcttt gaatacagcg gaccaaataa ggctcttgtt ggatttctgg acgccattac 16500 ccttgtgatg gagaatggtt ttgccatcgg agcctttatc tccattttcc tgaacttaat 16560 tttgccttac gagtttgacc ctgatttgac aaatgacagt cctggtcttt ccactacgaa 16620 tggtgttaac aatggcattg ttgaagtccg tggtatagat cccaacgatt ctctttccaa 16680 tacggacacg gaatatgcta acgaaaataa aaaagatgaa gttgatgttg ataaggttgt 16740 ttaaattttt ttatgtttta catgattatc cttataagaa gaacaatgaa agcaatgctt 16800 tcattgtttc tataaatgcc ttattcctaa atttgccgct ttgtttgttt ccgatttcat 16860 ttcttttcgt tgttgcattt tatttaatgg cttacatatt ttgtttaata atatttacat 16920 gtgttaattg gttgttaggt ttttcatcta tgtatacatt cacatcaaaa tttgatcagt 16980 ataatgtgct gatagcttgt ttatatattt catttcaata ataaaaatct ttacttagat 17040 gcttgtatta ctccgtttat aaaccatgta ttttccgact agtgaattta gttggattga 17100 tataaataat taaaagcgat aatatttgta tattgttata gaagaaaccc aaaaatcgta 17160 gtatgaaatt tgcagtattt tatttgctaa gaggaaatta agcagttaaa gaagcgaggt 17220 tttctttcaa gcgtgaatcc gtgtaacgtt gattta 17256 //