ID SPAC139 standard; DNA; FUN; 12770 BP. XX AC AL132667; XX SV AL132667.1 XX DT 26-OCT-1999 (Rel. 61, Created) DT 26-OCT-1999 (Rel. 61, Last updated, Version 1) XX DE S.pombe chromosome I cosmid c139. XX KW Aldehyde dehydrogenase; excision-repair; fructosyl amino acid oxidase; KW Fungal Zn(2)-Cys(6) binuclear cluster domain; KW histone acetyltransferase type b catalytic subunit; KW Mitochondrial carrier proteins; KW mitochondrial oxaloacetate transport protein; KW succinate semialdehyde dehydrogenase; transcriptional activator; KW XPG N-terminal domain. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-12770 RA McDougall R.C., Rajandream M.A., Barrell B.G., Saunders D., Harris D.; RT ; RL Submitted (26-OCT-1999) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk and XX DR GOA; Q9UTM7; Q9UTM7. DR GOA; Q9UTM8; Q9UTM8. DR GOA; Q9UTM9; Q9UTM9. DR GOA; Q9UTN0; Q9UTN0. DR GOA; Q9UTN1; Q9UTN1. DR GOA; Q9UTN2; Q9UTN2. DR SPTREMBL; Q9UTM7; Q9UTM7. DR SPTREMBL; Q9UTM8; Q9UTM8. DR SPTREMBL; Q9UTM9; Q9UTM9. DR SPTREMBL; Q9UTN0; Q9UTN0. DR SPTREMBL; Q9UTN1; Q9UTN1. DR SPTREMBL; Q9UTN2; Q9UTN2. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c139 is overlapped at the 3' end by cosmid c23C4, EMBL CC entry SPAC23C4, accession number Z99753. XX FH Key Location/Qualifiers FH FT source 1..12770 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c139" FT /map="IL" FT CDS join(complement(639..645),complement(1..597)) FT /db_xref="GOA:Q9UTN2" FT /db_xref="SPTREMBL:Q9UTN2" FT /label=SPAC139.01c FT /note="SPAC139.01c, len:201, SIMILARITY:Saccharomyces FT cerevisiae, MKT1_YEAST, mkt1 protein., (830 aa), fasta FT scores: opt: 165, E():0.00064, (28.3% identity in 223 aa)" FT /partial FT /gene="SPAC139.01c" FT /product="putative excision-repair protein" FT /protein_id="CAB59615.1" FT /translation="MTIRSLNLFIIDKKHQHKSSLSSFQNCKLGIDASFYLTQIIHSFT FT PQELQSLAVNGESEYLQHRISEFLEQLRTENITPIFVFNGIPLTFEASSQLEVPGKQKS FT HSALTDFEAFDPYDANIQRNMYRMDASGPANYGESKPTLLYTNQRDHLDRLCDQVKFYL FT DQCNVEYFVAPYLAMAQLAYFLNGTSSPYIDAIYGSTD" FT misc_feature complement(319..645) FT /note="Pfam match to entry PF00752 XPG_N, XPG N-terminal FT domain," FT misc_feature complement(598..609) FT /note="ctaattttttag, splice branch and acceptor" FT misc_feature complement(633..638) FT /note="gtaagt, splice donor sequence" FT CDS complement(1382..2344) FT /db_xref="GOA:Q9UTN1" FT /db_xref="SPTREMBL:Q9UTN1" FT /label=SPAC139.02c FT /note="SPAC139.02c, len:320, SIMILARITY:Saccharomyces FT oviformis, CAB52216, mitochondrial oxaloacetate transport FT protein., (324 aa), fasta scores: opt: 1060, E():0, (54.8% FT identity in 301 aa)" FT /gene="SPAC139.02c" FT /product="probable mitochondrial oxaloacetate transport FT protein" FT /protein_id="CAB59616.1" FT /translation="MSEKQTIKALPAHNPTQVKKLGPVSGFLSGGLAACGAVTLTNPFE FT VIKTRFQLQGQLTKLDPSKRIYKSVGQAFSLIARHEGIRGLQRGLGTAYVYQICLNGCR FT LGFYEPIRRTLNTWFLDDPKGNKLAINVASGAGSGLCGALFGSPFFLVKTRMQSYSPKF FT PVGQQYGYKHIFNAFSRIIKENGVKGLFVGADAAILRTVSGSSVQLPIYNWAKRMIEHY FT NLLEEGMIKHLTASAVSGFGVCCTMQIFDTVMTRMYNQKNKELYKNPIDCILKTIRSEG FT FFALYKGFGAHLARIAPHTIFCLTFVEQTNKLFLKFQKD" FT misc_feature complement(1403..2281) FT /note="Pfam match to entry PF00153 mito_carr, Mitochondrial FT carrier proteins," FT CDS join(3687..4577,4617..5564,5606..5644) FT /db_xref="GOA:Q9UTN0" FT /db_xref="SPTREMBL:Q9UTN0" FT /label=SPAC139.03 FT /note="SPAC139.03, len:625, SIMILARITY:Schizosaccharomyces FT pombe, O14130, putative 88.0 kd transcriptional regulatory FT protein c3c7.04 inchromosome i., (783 aa), fasta scores: FT opt: 297, E():5.5e-12, (23.6% identity in 585 aa)" FT /gene="SPAC139.03" FT /product="putative transcriptional activator" FT /protein_id="CAB59617.1" FT /translation="MSETTKSGSKKSGQTSRRAIHSCLACRRKKLKCDHGRPCSNCLKR FT STIQSCIYIDPGKTNYDKRFERGSEADELIDQLLSRVSMLEKRLNEVGTKSQSDYENQQ FT SHNLPSTPSADAETQRNIGSLSVLDDTKSQYANYSSSSHVLWHLRNYHYLNLDQDIQEE FT NDSLISPFFFRISPNESAYDYLPPKKVSDILIEQFFFRCHMLINVLHRPTFYVRYNDFW FT EKPHLRKPAFTSLLYAIYASALLATPVEVQKTWALGEDERYLQVDYHQAFRYALASSNF FT LFEPDLNALQALVLCQVVFDSDRIRAPPSLVGLILHVALCMGLHRDGSLYGLNPVISEI FT RRRVWANIVLSDLRTSETIGYPPQIVEGNYDTRLPSALPDEIHNVDSSVIISEATFVNI FT ITKVSRAYSKCLKVLLGIIAPNYTRLLELDRELSNFFKELIEVNIPTSNTMHERHIRLL FT VSYLSNRFPILLHFPFLLKKNSAQFAYSHSRALESATLALNQLYELGSNPEYSKYSWYL FT WRYPPFHPCIVLLLDLLNSQKIIYLDDERVVLLNKIFSLFPRSSGKEHYQKAWALLQTS FT RAKVWEKLGLSTVDVSTTDVRLTNFEFFDANNLDINWDDWDAIFQHCPF" FT misc_feature 3747..3869 FT /note="Pfam match to entry PF00172 Zn_clus, Fungal FT Zn(2)-Cys(6) binuclear cluster domain," FT misc_feature 4578..4583 FT /note="gtttgt, splice donor sequence" FT misc_feature 4603..4616 FT /note="ctaactcaatttag, splice branch and acceptor" FT misc_feature 5565..5570 FT /note="gtatgt, splice donor sequence" FT misc_feature 5592..5605 FT /note="ctaacaactgctag, splice branch and acceptor" FT CDS complement(5946..7247) FT /db_xref="GOA:Q9UTM9" FT /db_xref="SPTREMBL:Q9UTM9" FT /label=SPAC139.04c FT /note="SPAC139.04c, len:433, SIMILARITY:Penicillium FT janthinellum, Q92261, fructosyl amino acid oxidase., (437 FT aa), fasta scores: opt: 695, E():0, (30.7% identity in 420 FT aa)" FT /gene="SPAC139.04c" FT /product="putative fructosyl amino acid oxidase" FT /protein_id="CAB59618.1" FT /translation="MSRTIVIVGCGVFGLSTAVELAKNHSFDNIIAIDAEPVPSSMSAA FT NDINKIVRPEYADLKYMKLALEAMEKWRNDPELSSVYFECGRLSTISKDPYRARFDEVA FT QRNLRKLLGDSALINLSSSEEIRKKYPSLFSNSPLRSDMQAVVNEHAGYANSAASLKLL FT ELKARELGVEFVFGKAGKFKKFVVNHSETDIDKNDNHVSVQTEDGTIYHADTILLAVGA FT YLNAYLNTSHRVCAKGLPVAHIQLTDEEFKTYKNMPIIFDPDCAYAFPPYPVTKLIKLA FT STGYEYVCNVETDYDENSKVVSIPHSGPSKSSLPKYAIIQMRRFLDTFLPDLADRSLIN FT TKMCWISDTEDANFLIDKVPQFDNVFVANGDSGHAFKFLPNIGRYIAQRILGDLSEEWK FT DAWRWREDDKASELKWRCVRSLIDYKDAEFTYDK" FT CDS 10086..11567 FT /db_xref="GOA:Q9UTM8" FT /db_xref="SPTREMBL:Q9UTM8" FT /label=SPAC139.05 FT /note="SPAC139.05, len:493, SIMILARITY:Rattus norvegicus, FT SSDH_RAT, succinate semialdehyde dehydrogenase, (488 aa), FT fasta scores: opt: 1522, E():0, (47.5% identity in 484 aa)" FT /gene="SPAC139.05" FT /product="probable succinate semialdehyde dehydrogenase" FT /protein_id="CAB59619.1" FT /translation="MAPQFKRPELFGFDKSHAQSFVQGKWISSPNNKTFEVDNPATGEI FT IGKVADVSVEETKKAISAANEAFKTYKNFTHVQRSQLLERWAELIMENKDDLVKMLTLE FT NGKPLSQAEMEVTTCSGYLKWYAAEAVRTFGDVAPSSLQSQNFLISIKQPVGVSALITP FT WNFPAAMIARKGGAALAAGCTAIFLPAFRTPYVCLGLVRLAQEAGFPDGVLNVITSSDA FT SAHGKELTTNPIVRKVSFTGSTNVGKILMGQSASTIKKVSMELGGNAPFIVFPDFPIDQ FT AVESFCTIKFNSCGQVCVCPNRVYVHKNVYDEFVSKLTEKVKTIKVGDGFDSSSAVGPL FT ISQDGCKKVSKHIEDAVSKGAKITVGGKEISSSKGYFFEPTVLSGVTQDMLVASEETFG FT PLASVFKFDDTEEVIEWANDSDVGLAGYVFTNNLSTMIHVAKELEVGLVGANIEMVDEP FT FISFGGIKQSGFGKEAGRLGVQEFMVVKEINLKTL" FT misc_feature 10158..11561 FT /note="Pfam match to entry PF00171 aldedh, Aldehyde FT dehydrogenase," FT CDS join(12000..12057,12108..12211,12273..12491,12581..12696, FT 12768..12770) FT /db_xref="GOA:Q9UTM7" FT /db_xref="SPTREMBL:Q9UTM7" FT /label=SPAC139.06 FT /note="SPAC139.06, len:166, SIMILARITY:Saccharomyces FT cerevisiae, HAT1_YEAST, histone acetyltransferase type b FT catalytic subunit, (374 aa), fasta scores: opt: 187, FT E():7.6e-06, (34.1% identity in 185 aa)" FT /partial FT /gene="SPAC139.06" FT /product="putative histone acetyltransferase type b FT catalytic subunit" FT /protein_id="CAB59620.1" FT /translation="MSAVDEWVHNANECIEIVQVNEKHEKDCQYHPSNTYAIFGDAEVI FT YGYKDLNVTITYECPLMVPKLEISYSERLAPDSGVEPTDIEGTLNTYLKDRSIKVEGNS FT FDVHSANSIHNYSFNGKTFKILQATVLEASEIMQHLQIFSLFFIEGGSFIDLNDPRWMV FT YLL" FT misc_feature 12058..12063 FT /note="gtatgc, splice donor sequence" FT misc_feature 12094..12107 FT /note="ttaacacctgtcag, splice branch and acceptor" FT misc_feature 12212..12217 FT /note="gtaaga, splice donor sequence" FT misc_feature 12246..12272 FT /note="ttgattgcaaatagtaacagttattag, splice branch and FT acceptor" FT misc_feature 12492..12497 FT /note="gtatgt, splice donor sequence" FT misc_feature 12557..12580 FT /note="ctaataatcgtaatgtattaatag, splice branch and FT acceptor" FT misc_feature 12671..12770 FT /note="nominal overlap with cosmid SPAC23C4 S. pombe FT chromosome 1" FT misc_feature 12697..12702 FT /note="gtaagt, splice donor sequence" FT misc_feature 12754..12767 FT /note="ttaacaaaaataag, splice branch and acceptor" XX SQ Sequence 12770 BP; 4146 A; 2225 C; 2299 G; 4100 T; 0 other; gatccgtgga accatagatg gcatcgatgt aaggtgaaga tgtgccgttt agaaaatatg 60 ctaattgagc catagccaga tacggggcga caaaatactc cacattacat tgatctaagt 120 aaaactttac ctggtcgcaa agacgatcta aatgatctcg ctgattggtg tacaaaagtg 180 ttggtttact ttcgccgtaa ttcgcaggac cacttgcgtc catgcggtac atattacgct 240 gaatatttgc atcataagga tcaaaagctt cgaaatctgt caatgcacta tgactttttt 300 gctttcccgg cacttccagc tggctgctgg cttcaaaggt aagaggtata ccattgaaaa 360 caaaaatggg tgtgatattc tcagttctca actgctcaag gaattccgaa attctgtgtt 420 gtagatattc ggattcacca tttactgcca aactttgaag ttcctgtggg gtaaaggaat 480 gaataatttg agtcaagtaa aaacttgcgt caatacccaa cttacagttt tgaaaactgc 540 tcaagctaga tttatgttga tgctttttgt ctatgataaa caaattcaat gaacgaacta 600 aaaaattagc agatgagtag caaggtattt taacttactt gtcatttttt ttcttttttt 660 taactgaatt taccaaacag cagtttaaac cgtaaggcgg ttttttttta ctaaaccttt 720 aatagatcct taaaaacaaa cagattattt ttatatgtaa cggatatatt cagattttat 780 tatgttgtac tgaatagagg tgtccgatcc gtttattaga gtcagcagga acgagcaaat 840 tagtgaacac gaatactacg ataagaagtt cagaaaatat tttattaaac taacatgatt 900 tatctaaaaa acatataact gttggcgaaa tgtaaagatt tcaaataaaa acgacgcaaa 960 atgaagaaat ttatccattg tgactacaca aagcggtaat gtttccaatc tttaattata 1020 gagaaaataa gtatattaat aactaaataa aaggtaagtt gatatacaaa cgcagccaga 1080 tgcctgaaat ccaaaaacaa atacgtacat atattgagat aactgacgga tatatattac 1140 aaaagacaaa aacatgccga ttgatcaaaa acagcttgaa aagaaaaatc gacttttaaa 1200 tgaaagtaga gtggaaataa gtaacgagac aacgaatgta aataaaaatc gttcttagat 1260 acaaacatca tttctttaca atttaactgt tcacttgata tacaccaaag ccactggggg 1320 tttttatggt ttagtaccaa aattatttat aaataaagaa acgtgcgttt gaaaaaacaa 1380 cttaatcctt ttggaatttc aaaaagagtt tattggtttg ctccacgaag gtaagacaga 1440 aaattgtgtg aggagcgatt ctggccaagt gagcaccaaa acccttatat aaggcaaaga 1500 atccttcaga gcggattgtt ttaaggatgc aatcaatcgg atttttataa agctccttgt 1560 tcttttggtt gtacatacga gtcataacag tatcgaaaat ttgcatggtg cagcatacac 1620 caaatccaga aacagcacta gcagttaagt gtttgatcat accctcttcc aatagattgt 1680 aatgctcaat catgcgttta gcccaattat agataggaag ctgaacagag gaaccagaga 1740 cagtacggag aatggcagca tcagcaccaa caaacaaacc cttaacacca ttttccttaa 1800 taatacgact gaatgcatta aatatatgct tgtaaccata ctgctggcca acgggaaatt 1860 taggagaata cgactgcatg cgagtcttaa ccaagaaaaa gggagagcca aacaaggcac 1920 cacataaacc tgaaccggcg ccacttgcaa cgttaatagc taatttatta cccttgggat 1980 catcaaggaa ccacgtattc agagtacgtc gaatcggttc gtaaaacccg agacgacagc 2040 cattgaggca gatttgataa acataagcag taccaaggcc tcgttgaaga cctcttatac 2100 cttcatgtct agcgattaga gaaaatgcct gaccgacgct tttgtaaatt cgcttagaag 2160 gatccaattt tgtcaattga ccttgaagtt gaaaacgcgt tttaataact tcgaaaggat 2220 ttgtcagtgt tacagcacca caagctgcaa gaccacctga caaaaatcca ctaacgggac 2280 caagtttttt cacctgagta ggattgtgtg caggaagggc tttgatagtt tgtttctcag 2340 acatgactta atattgggat tttttcttcg aatttaaaca aaaaaatctg cctcaaatgg 2400 caattcaatt tgcgtagcaa gtgttggccg aaggaaaaag aattcttgca gttgagattt 2460 tttcagtgat aatagccttg attaaattgt gcgcggaaaa tttaccattg cggcaatttg 2520 ggaaggcaaa acgtaacttt cgtacggact caaaaaataa gcaaaatgat actaataaaa 2580 aaattataga ttgaattgca atttttttat ttacaaggca ccctaattgc tctatacttt 2640 ttccatttta atgctaaatt aaacaggtca catgttactt atgtttacta tttgaaaata 2700 cagatactag aacgcactta acctctttaa attaaggatt tacctacaat catatatatt 2760 ttttttttct ttctctgtcc tacaaatatt tggtagaatt ttaaaatttt ttgaataaaa 2820 gtcatttgaa agtttgagta atgtttgtca acaataaatg cgatcgttcg aaggaaggaa 2880 ggtacacaca gttaacattt aactgacttt acactttaaa ataggattcg ttggaaacgc 2940 atggtagata atgttaaagt aagacaaatg caaaatcata gtagcagtag ctttagatgt 3000 cattcacttc tgcaatgttg tactattata aagaaaatgc cataaagtga ttcaaataag 3060 tgcatgctct caaccgtcta cccttaacca aagttcttac tcagacaatt aagatgcctt 3120 ttagtaagat tttatacata cggggtataa attgtgatca atgaaaaaaa tgcaagtact 3180 aaatttgatg gatagtttgt cgcaaggcag gcaattgaat tttgaaatag aaatcagtca 3240 tatttaagaa tggtaatttg ttagtaaatg cattaaatcc ctgtgtaaat tatatgtttc 3300 tatttgagtg ctttacgtat ctaacgcatg ttatccgaaa gctgtctgct gttgagattg 3360 cttactattg aaattagtgg atatttataa aagttgtcca gtgtgccttg tgtttggtgt 3420 tacgaattta cttttcgcca acatccaaac acaagtgtct ttggttcaaa atcagtatag 3480 caataagatt taaagatata attcttgcct atttaaagcc aagactactt ttttatatat 3540 tacggaatta acttcttttc gctcctgtca attggtcgca agtatcattt ttttgacgtc 3600 tattgattca agaattagaa gaatctagca ttcaattgta ctttatcttt cacaatatta 3660 tataacttga tgtttaagaa gagcatatga gtgaaacaac caagtctggt tctaaaaaat 3720 cagggcagac atcacgtagg gcgatccatt cgtgtttggc ttgtcgaaga aaaaaactta 3780 aatgtgatca tggaagacct tgttccaatt gcttaaagcg atcaacaatc cagtcatgta 3840 tttatataga tcctgggaaa actaattatg acaagcgctt tgaacggggt agcgaagctg 3900 acgaattgat agatcagtta ctatcccgag ttagcatgct ggaaaaacgt ttaaatgagg 3960 tcggcactaa atcgcaatct gattatgaaa accaacaatc tcataatctt ccttccacgc 4020 cttcggcaga tgctgagaca cagcgaaaca ttggttctct ttcagtatta gatgatacaa 4080 aatcacaata tgctaactac tcgtcctctt cacacgtact ctggcattta aggaattatc 4140 attatcttaa cttagatcaa gatattcaag aagaaaacga ttctctgatt agtccgtttt 4200 tttttcgaat atcccccaat gaatctgcat acgactattt accccccaaa aaagtatcgg 4260 atattttaat tgagcagttc ttttttcggt gtcatatgct cattaatgtt ttacacagac 4320 caacttttta tgtacgatat aatgattttt gggaaaaacc gcacttgcga aaaccagctt 4380 ttactagttt attatacgca atctatgcta gtgcattact agctacacct gttgaagtgc 4440 aaaagacatg ggcgcttggt gaagacgaga gatatcttca ggtagattat catcaagctt 4500 ttcgctacgc actggcttcg tctaattttc tgtttgaacc agatcttaat gctttgcaag 4560 ctcttgttct ttgtcaggtt tgtgatattg aaatgggttt aactaactca atttaggttg 4620 tctttgattc tgaccgcatt cgcgctccac cttccttagt cggcttgatt cttcacgtag 4680 cgctatgcat gggccttcac agagatggct cgctttatgg acttaatccg gtaatttccg 4740 agattagacg tcgtgtgtgg gcgaatatag tcttgtcgga tcttagaact tctgaaacta 4800 ttggttatcc tcctcaaatt gttgagggaa attatgatac acgtcttccc tctgctttac 4860 ctgatgaaat tcataatgta gattcttccg ttattatttc tgaggccact tttgttaaca 4920 ttatcacgaa ggtttcacga gcatattcaa agtgtttgaa agttttgcta ggcattatag 4980 ctcctaatta tacacgttta ttagagcttg acagggagct ttccaatttt tttaaagaat 5040 tgatagaagt gaatattcca actagtaata ctatgcacga acggcatatt cgacttttag 5100 tttcctattt gtcaaacaga ttcccaattc tcttgcattt tccgttcctt ttaaaaaaaa 5160 attctgcaca attcgcctac agtcattcgc gtgctttgga gtccgcgact ctggctttaa 5220 accagctgta cgaactaggc agcaatccag aatactcaaa gtattcatgg tatctttgga 5280 gatatccgcc gtttcatccc tgcatcgtgc ttttgctcga tttactaaat tctcaaaaaa 5340 tcatttattt ggatgatgaa cgagttgttc ttttaaacaa aatattttct ctttttcctc 5400 gcagttctgg taaagagcat tatcaaaaag cctgggcact tttacaaact tcaagggcaa 5460 aagtttggga aaagcttggg ttgagcactg tcgacgtatc gaccactgat gtgaggctta 5520 caaattttga attttttgat gctaacaatc ttgatatcaa ttgggtatgt attatgtgtt 5580 tgtgtttcca gctaacaact gctaggatga ttgggatgct atatttcaac attgtccatt 5640 ctaaagctta ttgcaaatgt ctatttttta ttattttatt tcgtcacatt acgcgccaat 5700 tttgtattta aaaatttatt tatgccagtt cttacaatta cagaacaact acgtccgcta 5760 aagcgataag gttagtgaaa tgtcaactgg tcagatttaa agagttattt acgtttgttt 5820 gttgtcttat aatacgctgt agtttatcta tcgaaaataa taacataata aacagatagt 5880 taaatatata aatgcagcaa caaaactgtg agtaaaacta taggatataa aacaaaaaat 5940 taaactcact tgtcgtaagt aaactctgca tccttgtaat ctatcaaaga gcgaacacat 6000 ctccatttca gttctgaagc tttatcatcc tctctccaac gccatgcatc tttccattct 6060 tcagataaat cccctaaaat acgttgtgct atgtatctgc caatattggg aagaaatttg 6120 aaagcatgtc cgctatctcc gtttgcgaca aaaacgttat caaattgagg gaccttgtca 6180 ataaggaagt ttgcatcttc ggtgtcagaa atccaacaca tcttcgtgtt tatcaggctg 6240 cggtctgcaa gatcaggcaa aaaggtgtca aggaaacggc gcatttgaat aatggcatat 6300 tttggtagac tacttttaga tggtccggaa tgaggaatgg aaacaacttt tgagttttcg 6360 tcgtagtcgg tctcaacgtt acatacgtat tcatatccgg tgctggccaa ttttatgagc 6420 tttgtcacag gataaggagg gaaagcataa gcgcaatctg gatcaaaaat aataggcata 6480 tttttgtaag tcttaaattc ttcatcggtt agctgaatat gcgcgaccgg taaaccctta 6540 gcacagacac gatgagaagt atttaaataa gcgttcaaat aagcaccaac agctagtaaa 6600 atagtatcag catgatatat agtaccgtcc tctgtttgta ctgatacatg attgtcgttt 6660 ttatcaatat cagtttcgga atgattgacc acaaattttt tgaatttacc ggctttacca 6720 aaaacaaact caactcctag ctccctagcc tttaactcaa gtaattttag agaagcagct 6780 gaattcgcat aaccagcgtg ttcatttacg acagcttgca tgtctgagcg cagcggtgaa 6840 ttagaaaaaa gtgaaggata tttttttctt atttcttctg aactggaaag attaataaga 6900 gcagagtctc ctaaaagctt tctcaagttt cgttgggcta cctcatcgaa acgagctctg 6960 tatgggtctt tggaaatggt gcttaagcgg ccgcattcga aataaacaga ggacaattct 7020 gggtcatttc tccatttttc cattgcttcc aacgccaatt tcatatactt aagatctgca 7080 tattctggcc gaacaatctt gttgatatcg tttgctgcag acatgctgga aggaacgggt 7140 tcggcatcaa tagcaatgat attatcaaag gaatgatttt ttgccaattc aactgcagtt 7200 gaaaggccaa aaactccaca tccaactatg acaatggttc tcgacatggc tcagtgggta 7260 cttgattatg gctaacggaa tgaataaggg agccatcaac ctcgtggtct atgcaatgaa 7320 caattttagc atccaggctt ctcgcaataa atttatatca atcagtcaca atgagaacaa 7380 tatagtgttg caaagatatt gattgattga ttcattagca aaaaaagaag ccttcattca 7440 gctagataac catgtagtaa tcggttccat ttgattttgt aagaaaatgg ttaagaaatt 7500 atcctcaaca tagggtaagg tacataacaa agatcaagca attcgaccaa caaaggaagc 7560 agagatgtct cagaaattct tcattatttg aatctccaat ttaatgcatt attaacatag 7620 gcacgtgcta ttcgttttaa caattattta ggcacaacgg tattggtgtt gctggattga 7680 gcgcaaagga tgcaaacgta atgctgtgct gcgttatatg ttccagctga tagttttaaa 7740 agcctaagtt tctttattcg acctgcaaat gccaagttgc gttactgtat tataaatttt 7800 ggactgattc agctctggct ttatgttgat ctgataaacc gaatgagcta gcaggattgc 7860 agcattcatt atgctgtttc ctcgtcctca cagttaatat taactatctt cttccttatt 7920 tggcaaacca gtaaggcatc acaataatcc gctttccata aacagcggca tatgagttgc 7980 agagctttgt ttaccaaata ctgtatcgta acgaagagca agaatagagg gctacgtaat 8040 aaaaaaatcg ccgctgtgct aatgcaatcg ttacgtttca tttaaaagca tcaatccata 8100 tcgttatact aaatcaatgt ttacaaaatt cgcagaatgt tgctaaattg taatgcaaac 8160 aaactattgt attagtaaaa tattatcttt ttgtatgtct ggttcatgaa aatctctaga 8220 aaaaaaaagt agtaaatttt tcttccacct taataaccta acctatgtgt caataataac 8280 ccaagttagt ctcgcattat gatttcagtg tgacataaat cgacttttgt cagttaagtg 8340 atagttaaaa aataattaag aaatttatga attgttgttg catggaaaat tttcttggca 8400 caccaaacat atgaaaattc gtttaatgat ttaactgccg tctgtctgag tttaagaaaa 8460 taataaacct tagcagaaac cagaagtaag aaaagaaggt atgtagcata gaagattcac 8520 agacataaag ccgatatagc tttgtatgac aatgaaaatt taatggcagg atgagaaata 8580 gcaaaataaa tcaggtttga gcttttttca attgttgcgc atgtccaatt ttattttatt 8640 tttttttgtc aaatttttaa ttgataaaat aagatatcac caaaaataac gagtatatat 8700 tgtcgatctt cattcttcaa aagtgataaa acattacaaa gatttattca atgttaattt 8760 tgtaagcatt ttcatgttat gggattttta atcatttact tgttttttat tcgatactac 8820 agattaatgt tatttgcatg gtaaattgta tagtattact ttaagcgccg atcagtaata 8880 aagaaatttt aaagaaatta tcgattcttt catattcttc caaaaattac gtgcccatat 8940 caatcggaca tgcttcttcc attgctgcac tgaaaaaaaa gccattgtgt attcgtaaag 9000 cagtaaaaaa tggaaacatt gcgattacaa aattttaaaa ctatgtaaac aaacggtgaa 9060 tgcactgtat aagatccatg cagcatatac caattgagtt ttttattttt ttttgggtac 9120 tatatgataa ttgtcaactt taaaataaaa gttggacacc atatgaataa atgaattttt 9180 aaaattaaat atgaaataaa atatatggaa aaaatacgaa aaaaattgat ggtaaataaa 9240 ttaattaaaa ttaaattaaa tatgtaactt actatactga taactttaat aatcgttaga 9300 aaagcaagga aaaattaagc acggatacca caaatgttta attttatttt ttgataaaag 9360 tttcaatact attttagtta tttatttcac tccaattatg tcgctaaaaa aaaaaaaaaa 9420 aaaaaaaaaa aaaaaaaaga aaccgcatta atacaaaata cattttttaa tatgaaaagc 9480 gaagcgattt tacccactgt tcttttcata ctcattcaca gtagctgtag cttatattac 9540 tgccattcag tatagtaaag tcggtacata ttcacatatg gtggcactca attatatgat 9600 gtaaaaaatg caattccacc aagttcgcta tatacatcat tgaagaagac gggagccgta 9660 agctaacaaa ccagacacta tgatttataa gttagtctgc cgatatttac gcaaattcaa 9720 tacgcctttc tttttttcca ggggaaatgt ttgcatacac caagaacatg atgttgagac 9780 gtaaatctag tacggaaaac caagatgcat acgttatggt ttgatcatta aatgtcttgt 9840 tgaaaaatta taaatatgca tcgtttctct cgatgtttac actacattaa aaaaaagaaa 9900 tctgcagctt aatttgaaaa cactaaaaaa acctgcattc ttcttttttc cacgaaagat 9960 ctgttgctgc ttacgctatt atttgttatt attataaata ataataacat ttctatcgat 10020 aacttcgttt catatagttt ttaacattta ctccttccca cttttttgta taatactctt 10080 caaaaatggc ccctcaattc aaacgccctg agctctttgg ctttgataag tctcatgctc 10140 aatcttttgt tcaaggaaaa tggatttctt ctcctaacaa caaaactttt gaggttgata 10200 acccagctac tggtgaaata atcggtaaag tggccgatgt ctcagtagag gaaacaaaaa 10260 aagccatcag tgccgctaac gaggccttca aaacttataa aaattttact catgtccaac 10320 gtagtcagtt attggaacgc tgggcagagc ttattatgga gaacaaagac gacttggtca 10380 agatgcttac cttagaaaac ggcaagcctt tgagccaagc tgagatggag gtcaccacat 10440 gtagcggata tcttaaatgg tatgctgctg aagccgttcg tacctttggc gatgtagctc 10500 cttccagctt acaaagtcaa aactttctca tctccatcaa acagccagtt ggtgtcagtg 10560 ccttgattac tccttggaac ttccccgccg ccatgattgc tcgtaaaggt ggtgccgctt 10620 tggctgctgg ttgtaccgct attttcttgc ctgctttccg cactccctac gtttgcttag 10680 gtttagtcag gttggcgcaa gaggccggtt tccctgacgg tgtcttaaat gtgatcactt 10740 cttctgatgc atctgctcat ggtaaagaac tgactaccaa ccctatcgtt cgtaaggttt 10800 ccttcactgg tagtactaat gtcggtaaaa ttcttatggg acaaagtgcc agcacaatca 10860 agaaggtttc aatggagtta ggaggtaatg cccctttcat tgtattccct gacttcccca 10920 ttgatcaggc tgtcgaatct ttctgcacta tcaagtttaa ctcttgtggt caagtttgtg 10980 tctgccctaa cagagtttac gttcacaaga atgtttacga cgaattcgtc agcaagctta 11040 ccgaaaaagt caagaccatt aaagtaggag atggatttga ctcttcttct gctgttggcc 11100 ctttgatttc tcaagatgga tgcaaaaagg tcagcaagca cattgaagat gctgtttcaa 11160 agggtgccaa aatcactgtt ggtggaaagg agatttcctc aagcaaaggt tatttttttg 11220 aaccaaccgt gctctccggt gtaactcaag acatgttggt tgctagcgag gaaacattcg 11280 gcccactcgc ctctgtcttc aagttcgacg acaccgaaga ggtgatcgaa tgggctaacg 11340 acagtgatgt tggcttggcc ggttacgtct ttaccaataa cttgtccaca atgatccacg 11400 ttgccaaaga actagaggtg ggtcttgtag gtgccaatat cgaaatggtt gacgaaccat 11460 ttatttcctt tggcggcatc aaacagagcg gttttggcaa ggaagccggt cgtttgggcg 11520 ttcaagaatt tatggtggtt aaggaaatca atctcaagac tctttaagga ttttcgcttt 11580 agaaagctgc atattattga acaagcaatg atgtcctctt ttggttaatg actaaaaaat 11640 cctgatgtta tgactgtttt acatgtttgc gatacaaatc gtattttagt ttaatgatat 11700 caaaaaaatt taatacctga acatcgtggg tcatcgatga agaatggatt gttgtgtcag 11760 aaaatctata cttgtagtta ttgttctgag caatctgaaa agttataaag aattgtaggt 11820 tctaaaattg gcaatactgg agctagaaat ctatataata gtaaatattt tttaataata 11880 acaggtgtag cacgtgaaat tttgcgtcgc cttgtagttt gttacttcca actagacaca 11940 tgtatttttt gttgtttgac ttgaaatagg gtcaggtatt caattttccg tatgcagtga 12000 tgagtgctgt tgatgaatgg gtacataatg ccaatgaatg catagaaatt gtacaaggta 12060 tgctatgtta aattataatg tttttacctt gtgttaacac ctgtcagtaa acgaaaagca 12120 tgaaaaagat tgtcaatacc atcctagcaa tacatatgca atatttggag atgctgaggt 12180 tatttatgga tataaagatc taaatgtcac tgtaagatta aatcagcaag ttttagtcat 12240 gaaatttgat tgcaaatagt aacagttatt agataaccta tgaatgccca ttgatggtcc 12300 caaaactgga aatctcatat tcagagcgcc tagcaccaga ttcaggagtg gaaccaactg 12360 atattgaagg aacattaaac acttatctaa aagatcgttc cattaaggtt gaaggaaact 12420 catttgacgt tcattcggca aatagtattc ataactattc ctttaatgga aaaacattca 12480 agattttaca agtatgttcg attacctttc aattggagaa gtattcaatt attgaatatc 12540 cctatatgtt ctttggctaa taatcgtaat gtattaatag gcaacggttc ttgaagctag 12600 tgagattatg cagcatttgc aaatattttc cttatttttt attgaagggg gctcttttat 12660 tgaccttaat gatccaagat ggatggtata tttactgtaa gtttgttatt ttctacgcgt 12720 ctactttcct tttacctttt tatcgaggtt ttattaacaa aaataagtta 12770 //