ID SPAC1142 standard; DNA; FUN; 15999 BP. XX AC AL159951; XX SV AL159951.1 XX DT 07-MAR-2000 (Rel. 63, Created) DT 07-MAR-2000 (Rel. 63, Last updated, Version 1) XX DE S.pombe chromosome I cosmid c1142. XX KW arsenite-translocating atpase; copper transport; forkhead/HNF3 family; KW glucose derepression; swi2. XX OS Schizosaccharomyces pombe (fission yeast) OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. XX RN [1] RP 1-15999 RA Stevens K., Churcher C.M., Lyne M., Rajandream M.A., Barrell B.G.; RT ; RL Submitted (02-MAR-2000) to the EMBL/GenBank/DDBJ databases. RL European Schizosaccharomyces genome sequencing project, Sanger Centre, The RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: RL barrell@sanger.ac.uk XX DR GOA; O14270; O14270. DR GOA; Q9P7F7; Q9P7F7. DR GOA; Q9P7F8; Q9P7F8. DR GOA; Q9P7F9; Q9P7F9. DR GOA; Q9P7G0; Q9P7G0. DR SPTREMBL; O13797; O13797. DR SPTREMBL; Q10668; Q10668. DR SPTREMBL; Q9P7F5; Q9P7F5. DR SPTREMBL; Q9P7F7; Q9P7F7. DR SPTREMBL; Q9P7F8; Q9P7F8. DR SPTREMBL; Q9P7G0; Q9P7G0. DR SWISS-PROT; O13796; YKY1_SCHPO. DR SWISS-PROT; O14270; YKY8_SCHPO. DR SWISS-PROT; Q9P7F9; CTR5_SCHPO. XX CC Notes: CC Details of yeast sequencing at the Sanger Centre are available on CC the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CC During 1995 to 1996 about 66% of S. pombe chromosome 1 was sequenced CC by the Sanger Centre. The sequencing of the S. pombe genome is now CC being continued with funding from The European Commission. CC Fourteen European sequencing laboratories, including the Sanger Centre, CC are participating in the project. CC Protein coding regions (CDS) have been predicted with the help CC of computer analysis using the Genefinder program in PomBase CC (an ACEDB database) with additional predictions for the CC branch-acceptor sites supplied by the program Sp3splice. CC CAUTION: It is possible that for any individual CDS we may have CC underestimated or overestimated the number of introns/exons or CC we may not have chosen the correct splice donor/acceptor sites. CC CDS are numbered using the following system eg SPBC25H2.01c. CC SP (S. pombe), B (chromosome 2), c25H2 (cosmid name), CC .01 (first CDS), c (complementary strand). CC The more significant matches with motifs in the PROSITE CC database are also included but some of these may be fortuitous. CC The length in codons is given for each CDS. CC IMPORTANT: This sequence MAY NOT be the entire insert of CC the sequenced clone. It may be shorter because we only CC sequence overlapping sections once, or longer, because we CC arrange for a small overlap between neighbouring submissions. CC Cosmid c1142 is overlapped at the 5' end by cosmid c17G6, CC EMBL entry SPAC17G6, accession number Z99162, and at the 3' CC end by cosmid c8C9, EMBL entry SPAC8C9, CC accession number Z99168. XX FH Key Location/Qualifiers FH FT source 1..15999 FT /chromosome="I" FT /db_xref="taxon:4896" FT /organism="Schizosaccharomyces pombe" FT /strain="972h-" FT /clone="cosmid c1142" FT /map="IL" FT CDS 1..789 FT /codon_start=1 FT /db_xref="SWISS-PROT:O13796" FT /label=SPAC1142.01 FT /note="SPAC1142.01, " FT /partial FT /gene="SPAC1142.01" FT /gene="SPAC17G6.18" FT /product="hypothetical protein with putative coiled-coil FT region" FT /protein_id="CAB77008.1" FT /translation="IIDFANYLENSNKISDTPNMLYSSALAMFYVHGDTTDTRASMLAA FT FERAPYMLSELLDTLNISFTKSSIPSPQDPVQELHSAMYALYAKDSWSDPTVLAFINSI FT LEKETVTLHDVEGQFAELTENLSRRVILLNEQSLRKFLPQRILQGTILSFDPLPPDTYL FT SESQVFGRDISRRIASFLSDYLSRAREVNENEEEPPAHEFDLPPAEQLLQQIESEVGEE FT SEDGTPVMTRLRSFFGSLFTSTNSETEPAEESTEEMGQGD" FT misc_feature 1..4055 FT /note="nominal overlap with cosmid SPAC17G6 EM:Z99162 S. FT pombe chromosome 1" FT CDS join(complement(2029..2131),complement(1368..1988), FT complement(1090..1319)) FT /db_xref="SPTREMBL:O13797" FT /label=SPAC1142.02c FT /note="SPAC1142.02c, len:317, SIMILARITY:Caenorhabditis FT elegans., Q21746, similar to tpr domain repeats. ncbi gi: FT 1109816., (337 aa), fasta scores: opt: 505, E():4.2e-22, FT (30.8% identity in 321 aa)" FT /gene="SPAC1142.02c" FT /gene="SPAC17G6.19c" FT /product="conserved hypothetical protein" FT /protein_id="CAB77009.1" FT /translation="MSSNKVTAAIIDYLKQAITTGSISEEEKESLEVAAQCIQDSFKIK FT PEEIKPKSGDRLVAAFEEYEKLHPVEEDSTAHVNKEEAEKLKLEGNNAIAAKDYQKALD FT LYTKAIEIDPTSPVYYSNRAAAYNQLGQFENAVEDALTCLSLDPHHARAFGRLGRAKLS FT LGDAAAAADAYKKGLDFDPNNEVLKRGLEAANKQLNQPSDSSATSGADQARTSAGAAPD FT LGSIFGGGMPDLGSLMNNPAVMNMARNLMQSGALNNIMNDPNIANMARNFQSGGGMPDL FT SSLANNPQLQNLARNFMNNNNNGNTDNNNQGNPPPQ" FT misc_feature complement(1320..1336) FT /note="ttaataagtgattttag, splice branch and acceptor" FT misc_feature complement(1362..1367) FT /note="gtaagt, splice donor sequence" FT misc_feature complement(1989..2002) FT /note="ctaaccaaaatcag, splice branch and acceptor" FT misc_feature complement(2023..2028) FT /note="gtatgt, splice donor sequence" FT CDS complement(2418..4586) FT /db_xref="SPTREMBL:Q10668" FT /label=swi2 FT /note="SPAC1142.03c, len:722" FT /gene="swi2" FT /gene="SPAC17G6.20c" FT /gene="SPAC1142.03c" FT /product="swi2 protein" FT /protein_id="CAB77010.1" FT /translation="MNVNKKQESIPVNTGSESISSNDNERFEQGKGVGSNLGSHFFEPV FT EYYYSDGKPMNQTEASQMKGTFSRDFSLNEMNNEFITDSFFCTTTPDPKTESPSFVKYN FT AHCDDHPEISGHVSSNDKDFAYFEDKSENQPLVTLPNENNQVIEPLSSQSCKSQLSTQN FT YSESDFGWNQLCDLDPIFKSLAFTDDTNLFPAFADSEAALIMLKKREMTRVKHRAGRPR FT KYSYVNKDLNFEEGLPRRRGRPTGWRKYPEKEEIYPTLSPRIKKPRKVFDAVVIPVTIK FT PSIYTEPSLPHHIDWNNGCSEEFDFEPSREDEDFPDLTSDSTGQDPLSSEPTIFDISPL FT PSDMEPTFSENSLITINKMAIEERKQSRRLEQPLAESQHQEDLLNPYGVDQDFDETCIN FT ESEQQATHIPNSSIKFNYDYTPPKSATSHKHKRVDLLASRKENVWTGLYGKVQTEMVSN FT RGEAVLNENNSKNRTNVTKPNSYKNSVLSIGNNHSNHSNIIKPNTYKNTILSNENNTPN FT YSNVCLSTSLINRSLPSLKSTMHPGVNKDLITRPFKNVNKMSVRKALIKPFHPPISKIS FT RTRLTVSSPERLYCAKPISMATAPSETDSKLINRIRNLELEIGGLKEQLSVVELALDTD FT KNSKQIQVVERKIQNWRKSAQLAVEVLFPVFSLKFTTMLQEVPQSVLRTSANDLRTKPC FT SIGTYLEQLQIPFHLLQYNSETESWDLE" FT CDS 4781..6904 FT /db_xref="GOA:Q9P7G0" FT /db_xref="SPTREMBL:Q9P7G0" FT /label=SPAC1142.04 FT /note="SPAC1142.04, len:707, SIMILARITY:Saccharomyces FT cerevisiae, Q08625, chromosome xv reading frame orf FT yor206w., (710 aa), fasta scores: opt: 973, E():0, (36.4% FT identity in 706 aa), NOTE: Yeast protein interacts by FT two-hybrid assay with Ymr117p, a protein interacting with FT U2snRNP component" FT /gene="SPAC1142.04" FT /product="conserved hypothetical protein with putative FT coiled-coil regions" FT /protein_id="CAB77011.1" FT /translation="MVKLSSIIKARKANALAKKNDKIKKKDTDKGIRQKHSKKEGKDET FT LKRDVEKFIQNVNSEDTPSEDDSMSMDAFLEGGFEELDSANSNDAGSSRKRKNLPNENT FT QDSTSESSEEEEDGLESYQKQLEGLKEKDPEFYKFLEQNDQDLLEFNAAETDAMAKEID FT ENERLKSSSGKIVLTSDTIQQWQKLLETNHSLTTLQKVVQAFKAAAFLNEEEAEDLKYT FT ISDSKVFNDLLLLAIQYVPKVLNYHVPIQEDAKGKKFINTDSKVLPKLRPVLKSYGFSI FT LRLLEGMTDAKNISLLLREAQNVLPYMITYRKFLKQFTQATVEVWSSTRDDSVRFSAVV FT LLRTLCLTADITLLEFVLKEVYLGMARQSAYTTVHTLDKINFLKNSAVNLFLLDAESCY FT LIGFRYIRQLAITLRNTIHQPSKDSRKPVQSWSYVHSLDFWARLLSQAAWLSREKGVAS FT ELQSLVYPLVQIALGVIMSSPSSQLFPMRFHIIRSLIYLSRHTGVFIPLAPSLFEVLDS FT SYVSRKAKASTLKPLDFDVELRASSSYLRTKVYQDGLIDQLLELLSEYYVLYATDISFP FT ELVIPAIVRSKRFAKRSKNAKLNRGLLTLVNRLEQQSKFMTEKRNQQKFAPIDSDSVEQ FT FAQTIDWQQTPLGIYVVTQRQTREEQRKLIRESVQQDQEHKEQMRQKKKQALKSDDIEL FT DDLSEEEAEDIDE" FT rRNA 7615..7749 FT /note="SPRG5SA yeast (s.pombe) 5s rrna gene" FT CDS 9010..9531 FT /db_xref="GOA:Q9P7F9" FT /db_xref="SWISS-PROT:Q9P7F9" FT /label=SPAC1142.05 FT /note="SPAC1142.05, len:173, SIMILARITY:Schizosaccharomyces FT pombe, CAB52305, high affinity copper transporter ctr4, FT (289 aa), fasta scores: opt: 426, E():7.3e-22, (39.2% FT identity in 176 aa)" FT /gene="SPAC1142.05" FT /product="possible copper transport protein" FT /protein_id="CAB77012.1" FT /translation="MSLSKMSMSGMSGMGMGSSSNSSAATCRMSMLWNWYIHDSCFLAK FT SWHINTGNKFAGSIIGIFFFAVAIEGLSLVQRMFDRWIVAHSNGKTLSGPLRIFFPSST FT VHVTVWQQLIRAAMYSSFYLSATILMLIVMSFNGYAILFGFVGAWIGFFLFASDTYGTP FT STGTGCCESR" FT CDS 10347..11336 FT /db_xref="GOA:Q9P7F8" FT /db_xref="SPTREMBL:Q9P7F8" FT /label=SPAC1142.06 FT /note="SPAC1142.06, len:329, SIMILARITY:Mus musculus, FT O54984, arsenite-translocating atpase, (350 aa), fasta FT scores: opt: 1226, E():0, (55.0% identity in 329 aa)" FT /gene="SPAC1142.06" FT /product="putative arsenite-translocating atpase" FT /protein_id="CAB77013.1" FT /translation="MSFDPLPGTLENLLEQTSLKWIFVGGKGGVGKTTTSCSLAIQMSK FT VRSSVLLISTDPAHNLSDAFGTKFGKDARKVPGFDNLSAMEIDPNLSIQEMTEQADQQN FT PNNPLSGMMQDLAFTIPGIDEALAFAEILKQIKSMEFDCVIFDTAPTGHTLRFLNFPTV FT LEKALGKLGGLSSRFGPMINQMGSIMGVNANEQDLFGKMESMRANISEVNKQFKNPDLT FT TFVCVCISEFLSLYETERMIQELTSYEIDTHNIVVNQLLLDPNTTCPQCMARRKMQQKY FT LAQIEELYEDFHVVKVPQVPAEVRGTEALKSFSEMLVKPYVYPTSGKE" FT misc_feature 10422..10445 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS join(complement(12631..12805),complement(12016..12509)) FT /db_xref="GOA:Q9P7F7" FT /db_xref="SPTREMBL:Q9P7F7" FT /label=SPAC1142.07c FT /note="SPAC1142.07c, len:222, SIMILARITY:Homo sapiens, FT AAF29098, hspc134., (223 aa), fasta scores: opt: 482, FT E():2.4e-20, (39.6% identity in 227 aa)" FT /gene="SPAC1142.07c" FT /product="similar to yeast Snf7 protein involved in glucose FT derepression and in protein sorting in pre-vacuolar FT endosome" FT /protein_id="CAB77014.1" FT /translation="MSGFLRWFGGNRSKDTTKDTIVRFQEMLALYDKKEEVLERQIAEQ FT TEIARKNATTNKRLALTALKRKKMHENELVKIEGSRNNIEQQLFSIQNANLNFETLQAM FT RQGAEAMKSIQRGMDADKVDQIMDKIRDQQTISEEISTMISTPVGLNAEIDEDELANEL FT DELQQMELDSKMLGAEKPPVHTPAVPAVPSQVKDLPSISKPQELDEEEELRKLQAEFSL FT " FT misc_feature complement(12510..12524) FT /note="ctaacttacatatag, splice branch and acceptor" FT misc_feature complement(12625..12630) FT /note="gtacgt, splice donor sequence" FT CDS 13233..15464 FT /db_xref="GOA:O14270" FT /db_xref="SWISS-PROT:O14270" FT /label=SPAC1142.08 FT /note="SPAC1142.08, len:743, SIMILARITY:Saccharomyces FT cerevisiae, FHL1_YEAST, pre-rrna processing protein fhl1., FT (936 aa), fasta scores: opt: 428, E():1.2e-13, (25.4% FT identity in 755 aa)" FT /gene="SPAC1142.08" FT /gene="SPAC8C9.01" FT /product="similar to N-term of yeast FhlI transcriptional FT activator of the forkhead/HNF3 family" FT /protein_id="CAB77015.1" FT /translation="MPVAEIKNATQQPSSTNRVQAYAKLEFEKFSFFVQTLQVTMGRKA FT SNSSDCDVHLGDTKAISRQHAKIFYSFPNQRFEISVMGKNGAFVDGEFVERGKSVPLRS FT GTRVQIGQISFSFLLPEGSEEDGHLKETGITPLSLQQGKIAYSDEFGGKPTGSFHTVTS FT NQEKDLLFSHIKHESDLPLGLSPADTNISNATSIIEHPDAANAHTLASLNQPPKHLTVS FT PSSIQRLSPQPYVRPTSDERPIETDSSVSAPKVANHDEELKQGKSTSPSDTVLHPDLNG FT SPDTGDATQKPNLSYANLIARTLIANPNKKMTLGDICEWIANNWSYYRHQPPAWHNSIR FT HNLSLNKAFIRIPRRQNEPGKGSFWMLDPSYIDQFEGNFFRRTKKPTPSATPAAHPDTA FT RENELAAIQTKGISAGKTEQLNPQKETSRSKTHTSRGENVEDRPQSLLQNGIQPIIMRD FT GKLALNPEFFKNANGEQQAPNEQAVQAISLLQQHINKQLGPAAANNPEQATAIANALAV FT ALAQKLQKQQTQMQGPQQVQQQAKRRKAYTSQQLNPAPTAMPHPNITSPSPSISVTQRP FT AVNVGPPPYVRPSAPSKLPDTRQSIGDPLPPGAMANVSAGPSSVRSSSYNSTASESKSE FT ITSHQNLHTIPINKPFTSDRPLYSSPNDTLERVETGNQGQRMNSIGNASSFSKRDIMEN FT ENGSFDTNAKNGNNVDDSSSVRGMNLPSNSSDALRGVKRPLDETSSSYT" FT misc_feature 13356..13565 FT /note="Match to PF00498 FHA, FHA domain Score 66.35" FT misc_feature 14103..14387 FT /note="Match to PF00250 Fork_head, Fork head domain Score FT 156.92" FT misc_feature 14334..15999 FT /note="nominal overlap with cosmid SPAC8C9 EM:Z99168 S. FT pombe chromosome 1" FT CDS 15743..15999 FT /db_xref="SPTREMBL:Q9P7F5" FT /label=SPAC1142.09 FT /note="SPAC1142.09, len:85" FT /partial FT /gene="SPAC1142.09" FT /gene="SPAC8C9.02" FT /product="hypothetical protein" FT /protein_id="CAB77016.1" FT /translation="MEDSLLLSVNISDSLFTFSLKPLFSQYRKHIYFNDCFYSTFNKTK FT TIIVVILSGKLSDLIDFKSYIEFVLKTNNSYSAILISYYR" XX SQ Sequence 15999 BP; 4983 A; 2979 C; 2949 G; 5088 T; 0 other; ataattgatt ttgcgaatta cctggaaaat tcaaacaaaa tttcggacac gccaaatatg 60 ttatattcgt cagcacttgc catgttttac gtacatggtg atactaccga cacacgagcg 120 agtatgcttg ccgcctttga acgtgcacct tacatgctaa gtgaattgtt ggacactttg 180 aatatctctt tcacaaaatc ctctattcca tcccctcaag atccagttca agagttacat 240 tctgctatgt atgctttata tgctaaggat agctggtctg atcctacggt attagcattc 300 attaattcca ttcttgaaaa agaaaccgtg accctgcacg atgtagaagg acaattcgca 360 gaactcactg aaaatctctc taggcgtgtt atcctgttaa atgagcaaag cttgagaaaa 420 tttctaccac agagaatctt gcaaggaact attttatcct ttgatcctct acctcctgat 480 acatatttaa gcgagtcaca agtctttggt agagatatat ctcgtcgaat tgcgtcgttc 540 ttgtccgatt atttatccag agcaagagaa gttaatgaaa atgaggaaga accccctgct 600 catgagtttg atcttcctcc tgctgaacaa ttgctacaac agattgaatc ggaggttggt 660 gaagaatcag aagatggaac tccggtgatg acccgactac gttcattttt tggaagcttg 720 tttacatcaa caaactcaga gacggaacct gcagaagaaa gcacagaaga gatgggtcaa 780 ggggattgaa ttatttcaaa agaattgttt aatgaagtcc ttattttcat acaacgaaag 840 ctattgtaaa attatcaata aaaattagat gaactattta aaaataatac gaaaaacgat 900 gcaaacgcta ctgtaaatac ggtaatctta acaaacatgt acaatatgat tgattagcag 960 aatgattgta tatgcaaggt actaaaaaat gtcaaagcaa ttcttcaagt attcaaaatg 1020 aatttaaatg caagatataa actgcttgaa tgaaaagcaa aaacaaacaa atcaatatac 1080 acctatactt tattgagggg gaggatttcc ttggttattg ttatcagtgt tgccattatt 1140 gttattgttc ataaaattgc gagccaaatt ttgcagttgg gggttattgg caagagaact 1200 caagtcaggc atacctcctc cagattgaaa gttacgggcc atgttggcaa tattagggtc 1260 attcataata ttattcaaag cacccgattg catcaagtta cgcgccatgt tcataacagc 1320 taaaatcact tattaacaat gaataatgta tacactaaaa aacttaccag gattgttcat 1380 caaagaacct aaatcaggca tacctcctcc aaaaatggat ccaagatcag gagcggcacc 1440 agcagaagtg cgagcttggt cagctccaga agtagcggat gaatccgatg gttgattcaa 1500 ttgcttgtta gcagcttcca aacctctctt taaaacctca ttattgggat caaagtctaa 1560 gcccttctta taagcatcag ctgccgctgc tgcatcgcca agtgacaatt tggcacgacc 1620 aagtcgtcca aaggctcgag catgatgagg atctaaactt aagcatgtta aagcatcttc 1680 tacagcattt tcgaattgcc ctagctgatt atacgcggct gcacgattgg agtagtaaac 1740 tggagaggta ggatcgattt ctatggcttt agtgtataaa tccaaagctt tttgataatc 1800 ctttgccgca atggcattat ttccttcaag ttttaatttc tcagcctctt ctttattaac 1860 atgagcagtg gaatcctcct ccactggatg cagtttttcg tactcctcaa aagcagcaac 1920 taaacgatcc cctgacttgg gcttaatttc ttctggtttg attttaaaag aatcttgaat 1980 acattgagct gattttggtt agattatctt aaatggggtt acacatacca gcaacctcca 2040 agctttcctt ttcttcttca gaaatcgaac cggtggtaat agcttgcttc aaatagtcaa 2100 taatagccgc agtaactttg ttagagctca ttttcctaat cgttttaaga accgattttt 2160 ttcgtattac tgaaagtata tcgtgagatg cgcgaagggc aaaattattc caagcgccgt 2220 tatagatttt tatatacgta aacatgcaaa taataaaatg aatttttgat tcctaattat 2280 attgctatta aaataacatt agataactat agtaccttta atgtgaatca tgaactgtaa 2340 aatactgata tgacaaaaaa aaacaaaaat agatagaaac aacagacagg aagcaaagaa 2400 aaaactaaaa acatatatta ttccaggtcc cagctttctg tctcagaatt atattgaagg 2460 agatggaagg gtatttgcaa ctgttcaagg tacgtaccaa tggaacatgg cttggtgcgt 2520 aaatcattag ctgatgtgcg taaaacagac tgtggaactt cttgaagcat ggttgtaaac 2580 ttcaaagaaa aaacaggaaa tagcacttcg actgctaatt gcgcagattt tcgccaattt 2640 tggatttttc tttcaaccac ctgtatctgt ttagaatttt tgtcagtgtc aagagcgagc 2700 tctacaacgg ataattgttc tttcaagcca ccaatttcta attcaaggtt acggattctg 2760 ttaattagtt tgctatccgt ttcacttgga gcagtagcca ttgagatagg cttggcacaa 2820 tacagccgtt caggtgagga aacagttaag cgggttcgcg aaatcttcga aatcggagga 2880 tgaaatggtt taatgagagc ctttcgtaca gacattttat taacattctt aaatggccgc 2940 gtaattaaat ctttgttgac ccctgggtgc atagtagatt taagagatgg aaggcttcga 3000 tttatcaaag aggtagaaag acagacatta gaatagtttg gagtattgtt ctcattggac 3060 aaaatagtat ttttataggt gttcggttta ataatattag aatggtttga atgattattc 3120 ccaattgata aaacactgtt tttgtatgaa ttcggcttag tgacattagt acgatttttg 3180 ctattatttt cattcaacac agcttcgcct ctgttggaaa ccatttcagt ttgtactttc 3240 ccatacaatc cagtccaaac attctccttc cgagatgcta gaagatcgac cctcttatgc 3300 ttatgggagg tagcagactt agggggagtg taatcatagt taaatttaat acttgaatta 3360 ggaatatgcg tggcttgttg ttcagactca ttgatgcaag tttcatcaaa gtcttgatct 3420 acaccgtagg gattcaacaa atcttcttga tgttgagatt cagctagtgg ttgctcaagt 3480 cgacgtgatt gtttccgttc ttctattgcc attttgttaa tggtaattaa tgaattttcg 3540 gaaaaagttg gctccatatc actaggtaat ggagaaatgt caaaaatagt cggctcacta 3600 gacaatggat cttgaccagt agaatcagaa gttaaatcag ggaagtcttc atcctctctt 3660 gatggctcaa aatcaaattc ctcagaacaa ccattgttcc aatcgatatg atgaggtaac 3720 gagggctctg tatatatact aggttttatg gtaaccggaa tgactacagc atcgaaaact 3780 tttctcggtt tcttaatcct tggagacaga gtaggatata tttcctcctt ttcaggatac 3840 ttcctccagc ctgtaggtct tccccttctt cttggcaatc cttcctcgaa gttcaaatct 3900 ttattaacat acgaatactt tcttggcctt cctgccctat gcttcactct cgtcatttct 3960 cttttcttca gcataatcag tgcggcttca gagtctgcaa atgcagggaa tagattagta 4020 tcgtctgtaa aagccaaaga tttaaatata ggatcgagat cacacagctg gttccaacca 4080 aaatcacttt ccgaataatt ttgggttgat aattgagatt tacaactttg tgagcttaac 4140 ggttcaataa cctgattatt ctcgttagga agagtaacca gtggttgatt ttcagattta 4200 tcttcaaagt atgcaaagtc tttatcattc gaggacacat ggccgctaat ctctgggtgg 4260 tcatcacaat gggcattgta tttcacaaaa gagggagatt cagtttttgg atcaggagtc 4320 gttgtacaaa agaaagaatc tgtgataaat tcattattca tttcatttaa agaaaaatct 4380 ctagaaaagg ttcccttcat ctggcttgct tctgtttgat tcatcggttt accatcagaa 4440 taatagtatt ctaccggctc aaagaaatgg gatccaaggt ttgagccgac gccctttcct 4500 tgctcaaacc tttcattgtc gttagaggaa atactttcag atccggtgtt tactggtatc 4560 gactcctgct ttttgttcac attcataagg cctataaggt ttctcacgat tctcaaaaag 4620 caaaattctg ttcaaagcaa tatacattta ataaatttgc cggagtatga ttattaagga 4680 catatctttg gtgtggaaat tgtgaagaaa tttggactga gtatggtggg cactaattct 4740 tgaaggaggt attctaacaa cctctgtgca cataccacac atggtgaagt tatcttccat 4800 tataaaagcc agaaaagcta atgctttggc taaaaagaat gacaaaataa aaaagaaaga 4860 cactgataaa ggcatacgac aaaagcattc taaaaaggag ggaaaagatg aaacattgaa 4920 aagagacgta gaaaagttta ttcaaaacgt gaatagcgaa gacacccctt ctgaagatga 4980 ctccatgtca atggatgctt ttttggaagg cggatttgaa gaattagact ctgcgaattc 5040 gaatgatgca ggttcctcaa gaaaaagaaa aaatttgcca aatgaaaata cacaagactc 5100 tacctctgaa tcatcggaag aagaagagga tggcttggaa tcttatcaaa agcaattgga 5160 aggcctaaag gaaaaggatc cagaatttta caagttcctt gagcagaatg accaagactt 5220 gcttgaattc aacgccgctg aaacagacgc aatggcgaag gaaattgatg agaatgaacg 5280 tttgaaatct tctagcggaa aaatcgttct gacaagtgat acaattcaac aatggcaaaa 5340 gcttttggag acgaaccatt cattgaccac actacaaaag gtcgtgcaag cgtttaaggc 5400 agcagcattc ttaaatgagg aggaggctga agatttgaaa tacactatta gcgattcaaa 5460 agttttcaat gacctcttgt tgttagccat ccagtacgtc cccaaagtgt tgaattatca 5520 tgttcccatt caagaggatg cgaaaggaaa aaaatttata aacactgatt caaaggtgct 5580 tccgaagcta cgccctgtgt taaaatccta tggattttcg attttacgtt tgctagaagg 5640 gatgaccgat gccaagaata tctctttact acttcgggaa gctcagaatg tattgcctta 5700 tatgattacc tatcgaaaat tccttaaaca gtttacacag gcaactgttg aagtatggag 5760 ttcgactcgt gatgacagcg ttcggttttc agctgttgta ttgcttcgta cattatgctt 5820 gacagctgac ataactctgc tggaattcgt tttaaaagag gtttatcttg gtatggctcg 5880 acaatcagct tacactaccg ttcatacact cgataaaatt aatttcctga aaaatagtgc 5940 tgttaatctt tttttattgg acgctgaatc atgttattta atcggattcc gttacattcg 6000 acaacttgct attactcttc gtaacaccat tcatcaacct agtaaggatt ctcgaaagcc 6060 tgttcaaagc tggagttatg tgcattctct agacttttgg gctcgtttat tgagtcaagc 6120 agcctggttg agtagagaaa agggagttgc ttcagaatta caatctttgg tctatccttt 6180 agtccaaata gcccttggag ttataatgag ttcaccgtca tcgcaattat ttccaatgag 6240 atttcacatc atccgaagtc taatttactt atcgcgccat actggtgtgt ttatccctct 6300 tgcaccttcg ctattcgagg tcttggattc ttcttatgtg tcaagaaaag ccaaagctag 6360 tacgcttaag ccattggatt ttgacgttga gttgcgtgca tcttcgtcat acttaagaac 6420 aaaggtctac caggacggtt taattgatca attattggaa ctcttgagcg aatattatgt 6480 tttatatgcc actgacattt cattccctga gctcgttata cccgctattg tcagaagtaa 6540 gcgatttgct aaaagaagca aaaatgctaa acttaatcgt ggattgttga ctttggtgaa 6600 tcgccttgaa caacaatcaa agtttatgac tgagaagcga aatcaacaga agtttgctcc 6660 cattgattcc gattccgtag aacagtttgc acagacaata gattggcagc aaacgcctct 6720 tggtatttat gttgtaacgc aacgccaaac cagagaagag caaagaaaac tcattcgtga 6780 atcagttcag caagatcaag aacataagga gcaaatgcgg cagaaaaaga aacaagcgct 6840 caaaagtgat gatattgaat tggatgacct gagtgaagaa gaagcagagg atatcgatga 6900 gtaattattg gtgccttgta cgaaatgttt ttaagataat ctgtttgaca gttcagttta 6960 ggaaattcgt gctttgtaaa aattattaga taaacgtcaa gagtatatct ctttcggtct 7020 tgggttttta attaggagat acaaaaagaa aatatattgg gtttggttca atttagttta 7080 ctttatttgg tataatatat tttgaattta ttgtttttta accttaagta agtgatagag 7140 tatagcagtg tatcaatgta ggttttccag gttatacatt tccaaacata taaatacttt 7200 ttgacaggct tttataaata gacttgctta atctcttgca atataagtaa tggttgtcaa 7260 atataatggt ttaatatatt accacatgcg acaacgatgg caacacgtca atttgtatca 7320 agtatgtcca ttgttttcaa tttatcttca taatcattga ccaacccaaa ttgcgggaaa 7380 aaatacttcc ctactgaata cactcaataa aacaataact ggtatgtagt gattgatcat 7440 cataaaccat ttttcaaaag aaaacctaat tgatcgattt tattgccttt ttgtagtatt 7500 gttctacgca gtttttctta ctacgaacta ttcttctgca ctgataacaa gctacactta 7560 agggctgcat tcaagatttc ttgactatat aatttataaa ctagacatgt ttaatgtcta 7620 cggccatacc taggcgaaaa caccagttcc cgtccgatca ctgcagttaa gcgtctgagg 7680 gcctcgttag tactatggtt ggagacaaca tgggaatccg gggtgctgta ggcttcattt 7740 cgtttttttg tttttgtttc tgtgcaaaaa gaatgtttgt gttttcaatg cttcgataca 7800 attattgtct tgaactcgct gaaaccataa actgataatg aataaaccat taaagtacca 7860 aaaatataaa tgtgtacgat ttgaaatatt tttttttttt tttttttttt tttttttttt 7920 taggccatga atgacaactt tgttttaatt ttcttgtaat atctcataaa ggtttggttt 7980 ttataaccca ctcaatattt ggtgattttt attttatttt atttaaatgg accatacgtt 8040 cattccttat taagcaatta tgtcaagaat aaaaaaagaa tttaaaatca taatcgtttt 8100 aaaaaaaaaa ttttaaaagg agcagctaaa ttaaattaat gtgacattgc atggttattt 8160 ataaattatc ttctacaaat aattaaacca attaagtgta taaatgctcc tgtagtgctt 8220 taatcaaaag aagaatctta attgttattg tattcataca aatcttactt tacttttata 8280 tctatttaca acgtacgaaa atcgtatttg aatatcaatt taggcaaacc tcatttgttt 8340 attttttttg gagtttcttg taactcttaa tgtatacgat aacatcaccg ggattaaaat 8400 ttacatattc atattcatcc aaattccttt gtatgtttga tttaattaat taattaattt 8460 tgcttttttt ttttattttt atattctttt cgattaacgc gacccgccgc aataccttaa 8520 tcaccatttg gcgggaattt tgctgagcga ttatagctgg tagtttttac ccaaaggaga 8580 aaaagtcgca tatcagtaga tgatgctttt aaactgctat aaaaggtaat cctacccccg 8640 ttcactttga agcgatattt gagcgttcag cttaattgaa cattcaggac ttgaaaaaaa 8700 cctgtagtga tcattctaat tcaagtgtat aggtagcagt aagaagttgc taaattatac 8760 attttgtctg tctgcgaaaa aggcccagct catagagaga tatttcgctt aaaggtggta 8820 aaactagtgt tattaactta ctttcaacaa aagacatttg ttttcgcatt gttccggtta 8880 tacttgttat tttagtttaa gacgctttcc attgagtgtc ttcttttctt tctttttatc 8940 ggctcttatc ctttattgac agatacctaa gatacttctc aatatttggc taacgcttct 9000 tgcaacaaaa tgagcttaag taagatgagt atgagtggca tgagtggcat gggtatgggt 9060 agctccagta actcgagtgc tgcgacatgt cgcatgagta tgctatggaa ttggtatata 9120 catgactcgt gtttcctggc taaatcctgg catatcaaca ctggaaacaa attcgccggt 9180 agtattattg gaattttttt cttcgccgtc gctattgaag gtttgtccct cgttcaaaga 9240 atgtttgatc gctggattgt tgctcactct aatggcaaaa ctttaagtgg acctctgcgt 9300 atcttctttc caagttccac tgtgcatgtt actgtctggc aacaactaat acgagcagcc 9360 atgtattcat cgttttactt gtccgctacc atcctcatgt tgattgtaat gtcgtttaac 9420 ggatatgcca ttttgttcgg tttcgtaggt gcttggatag gatttttcct tttcgcgagt 9480 gatacttatg gaaccccatc cactggtact ggatgctgcg aatcaagata gtcatattta 9540 attgtacagg ggtattcata aggatccgat tttaatgtac tattaatact ttttacgatt 9600 gtttttgttt ggtgttgggt ttcgatagtg tgttttatgt ttttctttgt ttgcttatca 9660 gggattatat tcagacttag aaataataac tttttcttta attcagttta atatatctcc 9720 tctatcggta tgcaaaaact ggtagtttac taaatatgtt gttgatatgg atgcaaattt 9780 atatgatggt acaaaatagt atattctctg ctcagtatga ttcaaagttg ttccttgatt 9840 tcttgtgagt gctttagtca tcaacaaaca tctgtagctc tgatccttga tttacgttga 9900 atgattccat gtagttcttt tctttataac gaatatggta atcgagcttc agcaggccaa 9960 aacatattat acgattagaa aatccattta aaggaatttt tttaattatg aaatttcagc 10020 ataccgtatt tagcattcta ctagcatggc tttacgaatc cttgataaaa aacttactta 10080 attgttatat tgctagcgta tcaaaaatag gaacaaaaca tgctatacac tattaattgt 10140 agttgcaatg tacaattatt aagtctttaa ttaaattttt atctctgatc gttgggaact 10200 gatctgccgc gtacttagga tcttcatttt cacttgcaaa ctgtcgtaac acctatcctc 10260 agcatatcgc atcgtgcatc tggtcaacga gagtctataa gaagactagc ttcagattaa 10320 aaaaaaaaat tctctaataa agtaaaatgt ccttcgaccc attgcctgga accttagaaa 10380 accttcttga gcaaacttcc ttaaaatgga tttttgtagg aggaaaaggc ggtgtaggaa 10440 aaacaactac gtcgtgttca ttggccattc aaatgtcaaa agttagatcc tctgttctac 10500 ttatctccac ggatcctgct cacaatcttt ctgatgcctt tggcacgaaa tttggaaaag 10560 acgctcgtaa ggttcctggt tttgataatc tgagtgccat ggagatcgat cctaatttat 10620 ccattcagga aatgacagag caagctgacc aacaaaatcc caataatcct ttatctggaa 10680 tgatgcagga tttggctttt acaataccag gtatcgacga ggcattggca ttcgctgaaa 10740 tccttaagca gatcaaatct atggaatttg attgtgtcat tttcgatacc gctcctactg 10800 gacatacgtt aagatttttg aattttccaa ctgttttgga aaaagctctc ggcaagcttg 10860 gcggtctctc cagtagattt ggccctatga ttaaccaaat gggtagcata atgggtgtaa 10920 atgccaatga acaagatcta tttggaaaga tggaaagcat gcgtgctaat atttctgaag 10980 ttaacaagca atttaagaat ccagatctta ctacttttgt gtgtgtatgt atttccgagt 11040 tcctttctct ttatgaaact gaaagaatga ttcaagaact tactagttat gaaattgata 11100 ctcacaacat cgttgttaac caacttttgc ttgatcccaa caccacttgt ccccagtgta 11160 tggctagaag aaaaatgcaa caaaaatatt tggcgcaaat tgaagagctc tatgaagact 11220 ttcatgttgt caaagtaccg caagttccag ctgaagttcg cggtactgaa gctttgaagt 11280 ctttctctga gatgttggtc aagccttacg tttatcctac ttctggcaaa gaataatgta 11340 ttttttcaat cttatccact gctgttaata agggtgtcaa aagcctctaa atgtatattt 11400 tttaacaaat tgattgacag cttgaatatg catattagaa tggctgtttc taagttttta 11460 cattactttt attttgttga agaattctta tcgtttcctc agttgagctt gactatttgc 11520 caaagcaaat aaaccaaaag cgctaggttg atacactgtt taatgattaa acacaacagg 11580 attctgagca cactgtttag attaatatta atcaatttga caagatatga acgtgtctgg 11640 aataactcaa aacattaaaa agttaacttg aactaacagt catttgatac agttgtttta 11700 gtagaatgaa gaagacgtaa tatgtaaaat tcttcagcta gtttttccgt agattattta 11760 actacaccaa ttattaaaat acaatgaaaa aacacacatc cgaacatgag gacggagacc 11820 tataagttat agtctaataa tggtattgta cataaaattt gtatttaggc ttccatgatg 11880 actcataaca aggaaaacat agaatactaa caactgacaa attaaataat tccataagtt 11940 ataacagaaa ccttagaaga tgactttaac atattgagaa aataataaaa ataccgagca 12000 agcgtactgg tcactttaaa gagagaattc agcctgtagt tttcgaagtt cttcttcttc 12060 atccaattct tgaggctttg aaatagaagg gaggtctttg acttgagacg ggacagcagg 12120 aacagcagga gtgtgtacag gaggtttctc agctcccaac atcttgctat caagttccat 12180 ttgctggagt tcatctaact cgttggccaa ttcatcttca tcaatctcag cattcaaacc 12240 gacaggagtg ctaatcatag tagaaatttc ctcagagatt gtctgttggt cacgaatctt 12300 atccatgatc tgatccactt tatcagcatc cataccacgt tgaatgctct tcatagcttc 12360 agctccttgt ctcatagctt gtaatgtctc aaagttgagg ttggcattct gtattgagaa 12420 aagttgctgc tcaatattgt ttctactacc ctctatttta accagttcat tttcgtgcat 12480 tttctttcgc tttaaagcag tgagggccac tatatgtaag ttagtttata aaaatcattt 12540 aatttacatg cacatcgttg cttcaccgag actacaaatg tgatcaagca aacggtacat 12600 ttcctgatgg aagtttaact atagacgtac atcgtttgtt tgtcgtagca ttttttctag 12660 caatttctgt ttgctctgca atttgacgct ctaaaacctc ttccttctta tcatataatg 12720 cgagcatctc ttgaaatctt acaatcgtat cttttgtagt atccttagag cgattgcccc 12780 caaaccatct taaaaatcca gacattttat caattgtaca attttaaaac aaatctatca 12840 agtgtaaacc gataacaaat cagaatttga gtttttcgtt ataatggaag taaaggcgca 12900 ataacgagat actaaacgaa aatttcgaga cttatgaatc gaaatttccg ctagataagt 12960 ttactgatga gaatttactt agacagaaac cctttggctt ctctaggata atggagttgg 13020 taggtggtaa tcaaccgtat ttaacaattg tattccacca actacacaaa cggtagaaaa 13080 ttcgtaattt ctgctgtaaa gccgaagaga cgttgttaca gcgtcagaaa gctatttttg 13140 atatagaaat aagctttcta gtctcattgt gctttcaatt ggctagaagt ttagcttact 13200 ataaaaaaag gaagtctttg ggtcattaag gcatgcctgt tgcagagata aaaaatgcga 13260 cgcaacaacc atcaagcacg aatagagttc aggcatatgc caagctcgaa ttcgagaagt 13320 tttccttttt cgtgcaaacg ttacaagtga caatgggtcg aaaggcgagc aattcaagtg 13380 attgcgatgt tcacttgggc gatactaaag ccatctctcg ccagcatgca aagatatttt 13440 acagctttcc taaccaaaga tttgaaattt cggttatggg aaagaatggt gcctttgttg 13500 atggcgaatt tgtggaaaga ggaaaatcag tccctttgcg cagcgggacg cgggttcaaa 13560 tcggtcaaat ttcgttttcg tttctattgc cagaaggatc ggaggaggac gggcatctaa 13620 aagaaacagg aatcaccccg ctatcattac aacaagggaa aatagcatat tcagatgaat 13680 ttggaggaaa accgacaggt tcatttcaca ccgtgacgtc taatcaagaa aaggacttat 13740 tgtttagtca tattaagcat gagtctgatc ttccgttagg tctttcacct gctgacacga 13800 atatctcaaa tgccacctct ataatcgaac atcctgacgc tgcaaatgct cacactttag 13860 cttccctaaa ccaacctcct aagcatctta ctgtttcccc ttcttcaatc cagagattga 13920 gtccccaacc ttacgttcga cctacatctg atgaacggcc tattgaaacc gactcttccg 13980 tttctgcacc taaagtcgca aaccatgatg aagagttaaa acaagggaaa tctacttctc 14040 catctgatac agtgttacat ccggatttaa atggatcacc cgatacaggc gatgctactc 14100 aaaaacctaa tctctcgtat gctaatttaa tcgcacgtac tctaattgcc aaccccaaca 14160 aaaagatgac actgggagac atatgtgaat ggattgctaa caattggtcc tattatcgac 14220 atcagcctcc tgcttggcat aattccatac gacataactt atcattaaac aaagcattca 14280 ttcggattcc gagaaggcaa aacgagccag gaaaaggctc cttttggatg cttgacccct 14340 cttacataga tcaatttgag ggtaatttct ttagaagaac aaaaaagccc accccttctg 14400 ctacaccagc tgctcatcct gatactgcta gggagaatga attagccgct atccagacaa 14460 agggtatatc agctggaaaa accgaacagc ttaatccgca aaaagaaact agtcgtagta 14520 aaactcatac ttcccgagga gaaaatgtag aggatcgacc acaatcctta cttcaaaatg 14580 gcattcaacc tatcattatg cgcgatggga aacttgcttt gaaccccgag tttttcaaga 14640 atgcaaatgg agagcaacag gctcccaacg agcaagccgt tcaagcaatt tcactactcc 14700 aacagcacat taataagcag ctaggacctg ccgctgccaa caacccggag caagccacag 14760 cgattgcgaa tgctctcgct gtggctttag cccaaaaact tcaaaagcag caaacgcaaa 14820 tgcaagggcc ccaacaagtg caacaacagg caaagcgtcg taaagcttat acttcacagc 14880 aacttaatcc ggcgccgact gcaatgccgc accctaacat aacatcaccg tctcctagta 14940 tctcagtcac tcaacgtcct gcagtaaacg ttggaccacc tccatatgtt aggccatctg 15000 ctccttcgaa gttaccagat acacgccaga gtattggaga cccgttaccc ccaggagcaa 15060 tggctaatgt gtccgcgggg ccatcgtcag ttcgatcatc gtcgtacaac tccactgctt 15120 ctgaaagcaa atcagagata acaagccatc aaaatctaca caccatacca ataaacaaac 15180 cattcacttc tgatcggcct ttatactctt cgcctaatga tactttagag agagttgaaa 15240 caggcaatca aggacaaagg atgaattcca ttggaaatgc atcaagcttt agtaaaagag 15300 atataatgga aaacgaaaat ggatcttttg atactaatgc aaagaacgga aacaatgttg 15360 acgactcatc ttcagtaagg ggcatgaatt taccatcaaa ctcaagcgac gctttacgag 15420 gagtaaagcg accgttggac gagacatcat cctcttatac ctgaatttac taatgctcat 15480 gcacgtaacg ttgttgatga cttcttaatt aatacattag tgccgaaaat tacacttacc 15540 agcatgcata agctgtttca tttttctttt tttgacagtg attgcacaac ttggtctttg 15600 ggtggtttct acttttattt ctcatgtgtt taatgtttac cttagttaat actttacata 15660 ataaattgcc gtctggtttt atttcattta ataagcattt tcgttttctt gtcgaaaaag 15720 ttaatagcaa agcaggaagg gtatggagga ttcgcttttg ttatctgtga acattagcga 15780 ttccttattt acgttttcat tgaaaccttt gtttagccaa tacagaaagc atatttactt 15840 caatgattgt ttttatagca cttttaataa gaccaaaact attattgttg taatcctgtc 15900 gggcaagctc tctgatctga tagacttcaa aagttacatt gaatttgttt tgaaaacaaa 15960 caactcatat tcagcgattc taatttctta ctatagatg 15999 //