Last updated: 2024-12-30 427965 annotations 4705 curated publications
Ontology term: abnormal meiotic chromosome organization (FYPO:0006759)
Definition Parents
A cellular process phenotype in which chromosome organization is abnormal during the meiotic cell cycle. is_a abnormal chromosome organization
is_a abnormal meiotic cell cycle process
Single locus phenotype annotations for FYPO:0006759 and its descendants
Cell
Filters:
+ abnormal chromatin loop formation during meiotic prophase I
rec8-F204S(aa)/rec8-F204S(aa)
+ abnormal chromatin remodeling during meiosis I
mre11Δ/mre11Δ ,   rad50Δ/rad50Δ
+ abnormal chromosome segregation during meiosis I with premature sister kinetochore separation, lagging chromosomes, and normal chromosome separation
clr4-F449Y(aa)/clr4-F449Y(aa)
+ abnormal homologous chromosome pairing
num1Δ
+ abnormal homologous chromosome pairing at cis-acting homologous chromosome pairing region during meiotic prophase I
rec8-F204S(aa)/rec8-F204S(aa) ,   wpl1Δ/wpl1Δ
+ abnormal linear element assembly
rec8-110(unknown) ,   rec8Δ ,   rec8-F204S(aa)/rec8-F204S(aa)
+ abnormal linear element maturation
cdc2-asM17(K79E,F84G aa)/cdc2-asM17(K79E,F84G aa)
+ abnormal meiotic centromere clustering
dhc1-d2(unknown)
+ abnormal meiotic centromere clustering during meiotic prophase I
alp14Δ ,   dis1Δ ,   klp2Δ
+ abnormal meiotic centromere clustering resulting in centromere-spindle pole body colocalization during prophase
pat1-114(V155G,P219S,L291F aa)
+ abnormal meiotic centromere clustering with centromeres dissociated from spindle pole body
sad1.2(T3S,S52P aa)
+ abnormal meiotic chromosome condensation
top2-191(unknown)
+ abnormal meiotic sister chromatid cohesion
rec8-S552P(aa)/rec8-S552P(aa) ,   mes1Δ/mes1Δ
+ abnormal meiotic sister chromatid segregation
nup132Δ ,   psc3-2T(unknown)/psc3-2T(unknown) ,   pof3Δ/pof3Δ
+ abnormal meiotic telomere clustering
bqt3Δ ,   bqt4-ΔN(1-262 Δaa) ,   bqt4-F61A(aa) ,   bqt4Δ ,   dlc1Δ ,   kms1-1(1039 Δnt) ,   lot2-s17(unknown) ,   rap1-D499A,E500A(aa) ,   rap1-DD337AA(D337A,D338A aa) ,   rik1Δ ,   taz1-uv3(A606V aa) ,   taz1Δ ,   dot2-439(E33*)/dot2+ ,   mat1-Mi+/mat1-Mm143(unknown) ,   mei4-512(unknown)/mei4+ ,   mei4-550(unknown)/mei4+ ,   mei4-636(unknown)/mei4+
+ abolished meiotic sister chromatid cohesion at centromere during meiosis I
moa1Δ ,   eso1-G799D(aa) ,   psm3-K105R,K106R(aa) ,   bub1Δ/bub1Δ ,   moa1Δ/moa1Δ ,   rec8-2A(S449A,S450A aa)/rec8-2A(S449A,S450A aa) ,   rec8-S450A(aa)/rec8-S450A(aa) ,   sgo1Δ/sgo1Δ
+ abolished meiotic telomere clustering
bqt1Δ ,   bqt2Δ ,   bqt4-F46A(aa) ,   rap1-F503R(aa) ,   rap1Δ
+ decreased global homologous chromosome pairing
rec8-110(unknown)
+ decreased homologous chromosome pairing at cis-acting homologous chromosome pairing region
bqt1Δ ,   rec8Δ/rec8Δ
+ decreased homologous chromosome pairing at cis-acting homologous chromosome pairing region on chromosome 1
omt3Δ affecting omt3
rhn1Δ affecting omt3
+ decreased homologous chromosome pairing at cis-acting homologous chromosome pairing region on chromosome 2
ctf1Δ affecting sme2
pab2Δ affecting sme2
pcf11-degron(disruption)[Knockdown] affecting sme2
rhn1Δ affecting sme2
rna15-degron(disruption)[Knockdown] affecting sme2
seb1-E38(R340*)[Knockdown] affecting sme2
+ decreased homologous chromosome pairing at cis-acting homologous chromosome pairing region on chromosome 3
rhn1Δ affecting lncRNA584
seb1-E38(R340*)[Knockdown] affecting lncRNA584
+ decreased meiotic sister chromatid cohesion
rec11Δ ,   rec8-110(unknown) ,   pds5-him(P84A,D85A,P87A aa) ,   rec11Δ/rec11Δ ,   rec11Δ/rec11Δ
+ decreased meiotic sister chromatid cohesion along chromosome arms
rec11Δ ,   rec8Δ ,   psm3-ED(T182E,S1001D aa)/psm3-ED(T182E,S1001D aa) ,   rec8Δ/rec8Δ
+ decreased meiotic sister chromatid cohesion at centromere
rad21-K1(unknown) ,   mrc1Δ ,   pat1-as1(L95G)(aa)[Knockdown]
+ decreased meiotic sister chromatid cohesion at centromere during meiosis I
bub1-KD(K762R,D900N aa) ,   moa1Δ ,   psm3-K105R,K106R(aa) ,   rec8Δ ,   bub1-KD(K762R,D900N aa) ,   spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
sgo1Δ affecting rec8
+ decreased meiotic sister chromatid separation
spo6Δ
+ decreased regional homologous chromosome pairing
hop1Δ ,   mek1Δ ,   rec10Δ ,   rec25Δ/rec25Δ ,   rec27Δ/rec27Δ
+ delayed onset of homologous chromosome pairing at cis-acting homologous chromosome pairing region
sme2-m(CU329671.1:g.33962T>C,CU329671.1:g.33960T>C,CU329671.1:g.33955T>C,CU329671.1:g.33950A>G)[Null] ,   sme2ΔA((-1030)-1586 Δnt) ,   sme2ΔB((-1030)-582 Δnt) ,   sme2ΔC((-925)-(-54))[Null] ,   sme2ΔE(1058-1586 Δnt) ,   sme2ΔF(1425-1586 Δnt)
+ equational sister chromatid segregation during achiasmatic meiosis I
mis4-14A(S60A,S61A,S80A,S134A,S147A,T192A,T202A,S288A,S351A,S794A,S831A,S868A,T909A,S1407A aa)/mis4-14A(S60A,S61A,S80A,S134A,S147A,T192A,T202A,S288A,S351A,S794A,S831A,S868A,T909A,S1407A aa) ,   psm3-2A(T182A,S1001A aa)/psm3-2A(T182A,S1001A aa) ,   psm3-3A(S110A,T182A,S1001A aa)/psm3-3A(S110A,T182A,S1001A aa) ,   psm3-S110A(aa)/psm3-S110A(aa) ,   psm3-S110D(aa)/psm3-S110D(aa) ,   wpl1Δ/wpl1Δ
+ equational sister chromatid separation at meiosis I
bub1(1-179)(180-1044 Δaa) ,   bub1(1-585)(586-1044 Δaa) ,   bub1-K762M(aa) ,   bub3Δ ,   mph1Δ ,   fta2-9A(S2A,S7A,S10A,S15A,S16A,S17A,S18A,S21A,S23A aa) ,   fta2-9D(S2D,S7D,S10D,S15D,S16D,S17D,S18D,S21D,S23D aa)
+ increased duration of meiotic sister chromatid cohesion at centromere during meiosis I
rec8-2E(S449E,S450E aa)/rec8-2E(S449E,S450E aa)
+ increased homologous chromosome pairing at cis-acting homologous chromosome pairing region
mmi1-48(G485E aa)
+ increased length of chromatin loops during meiotic prophase I
wpl1Δ/wpl1Δ
+ lagging chromosomes during meiosis II
csm1Δ ,   sgo1Δ ,   klp6Δ ,   dbl2Δ/dbl2Δ
+ sister chromatid nondisjunction at meiosis II
akr1Δ ,   bub1-KD(K762R,D900N aa) ,   csm1Δ ,   hta1-K119E(K120E aa) ,   hta1-S121A(S122A aa) ,   hta2-K119D(K120D aa) ,   hta2-K119E(K120E aa) ,   hta2-S121A(S122A aa) ,   mde4Δ ,   par1Δ ,   rec8Δ ,   sey1Δ ,   tht1Δ ,   csm1Δ ,   swi6Δ ,   ctf18::ura4+(nt1603)(disruption)[Null]/ctf18::ura4+(nt1603)(disruption)[Null] ,   dcc1::ura4+(nt180)(disruption)[Null]/dcc1::ura4+(nt180)(disruption)[Null] ,   acb1Δ/acb1Δ ,   cid12-DADA(D77A,D79A aa)/cid12-DADA(D77A,D79A aa) ,   clr4Δ/clr4Δ ,   dbl2Δ/dbl2Δ ,   par1Δ/par1+ ,   ppa2Δ/ppa2+ ,   psm3-ED(T182E,S1001D aa)/psm3-ED(T182E,S1001D aa) ,   rec8Δ/rec8Δ ,   sgo1Δ/sgo1+ ,   sgo2Δ/sgo2+ ,   swi6Δ/swi6Δ
+ sister kinetochore dissociation in meiotic metaphase I with equational sister chromatid segregation in meiosis I
bub1-KD(K762R,D900N aa) ,   bub1Δ ,   cnp3-A552T(aa) ,   cnp3-Y607C(aa) ,   rec8Δ ,   sgo1Δ ,   bub1-KD(K762R,D900N aa) ,   ctf8-(unknown) ,   dcc1-(unknown) ,   moa1Δ ,   pds5-(unknown) ,   rec12-Y98F(aa) ,   rec12Δ ,   rec7Δ ,   rec8Δ ,   sgo1Δ ,   bub1-Δkinase(631-1044 Δaa)/bub1-Δkinase(631-1044 Δaa) ,   bub1-P*(T340A,T423A,T455A,S466A aa)/bub1-P*(T340A,T423A,T455A,S466A aa) ,   bub1Δ/bub1Δ ,   rec12Δ/rec12Δ ,   bub1Δ/bub1Δ ,   cid12-DADA(D77A,D79A aa)/cid12-DADA(D77A,D79A aa) ,   clr4-F449Y(aa)/clr4-F449Y(aa) ,   ctf8Δ/ctf8Δ ,   dam1Δ/dam1Δ ,   dcc1Δ/dcc1Δ ,   mad2Δ/mad2Δ ,   moa1Δ/moa1Δ ,   pds5Δ/pds5Δ ,   psm3-ED(T182E,S1001D aa)/psm3-ED(T182E,S1001D aa) ,   rec8Δ/rec8Δ
+ sister kinetochore dissociation in meiotic metaphase I, normal chromosome segregation in meiosis I, and sister chromatid non-disjunction in meiosis II
hta1-K119D(K120D aa) ,   ark1-as3(L166A,S229A,Q28R,Q176R aa) ,   bub1-K762M(aa) ,   bub1Δ ,   bub3Δ ,   moa1-T101A(aa) ,   moa1Δ ,   mph1Δ ,   rec11Δ ,   rec12-Y98F(aa) ,   rec12Δ ,   rec7Δ ,   sgo1Δ ,   moa1Δ/moa1Δ ,   rec11Δ/rec11Δ ,   rec8-2A(S449A,S450A aa)/rec8-2A(S449A,S450A aa)
+ unstable meiotic telomere clustering
crs1Δ/crs1Δ
Multi-locus phenotype annotations for FYPO:0006759 and its descendants
Cell
Filters:
+ abnormal chromosome segregation during meiosis I with premature sister kinetochore separation, lagging chromosomes, and normal chromosome separation
rec12Δ sgo1Δ
+ abnormal linear element maturation
cig1Δ/cig1Δ crs1Δ/crs1Δ
+ abnormal meiotic sister chromatid cohesion
acb1Δ/acb1Δ mes1Δ/mes1Δ ,   dms1Δ/dms1Δ mes1Δ/mes1Δ
+ abolished meiotic sister chromatid cohesion at centromere during meiosis I
clr6-1(G269D aa) eso1-G799D(aa) psm3-K105R,K106R(aa) ,   moa1Δ psm3-KKQQ(K105Q,K106Q aa)
+ abolished meiotic telomere clustering
bqt2Δ mcp6Δ
+ decreased meiotic sister chromatid cohesion
rec11Δ rec8-RDRD(D369R,D370R,R373E,E379R,E381R,R384E aa) ,   eso1Δ pds5-him(P84A,D85A,P87A aa) wpl1Δ ,   eso1Δ wpl1Δ ,   psc3+[Overexpression]/psc3+[Overexpression] rec11Δ/rec11Δ
+ decreased meiotic sister chromatid cohesion at centromere during meiosis I
bub1-KD(K762R,D900N aa) hta1-S121A(S122A aa) hta2-S121A(S122A aa) ,   clr6-1(G269D aa) eso1-G799D(aa) ,   hta1-S121A(S122A aa) hta2-S121A(S122A aa)
+ equational sister chromatid segregation during achiasmatic meiosis I
rec12Δ/rec12Δ rec8-2A(S449A,S450A aa)/rec8-2A(S449A,S450A aa)
+ equational sister chromatid separation at meiosis I
bub1(1-179)(180-1044 Δaa) sgo1Δ ,   bub1(1-179)(180-1044 Δaa) sgo2Δ ,   bub1(1-585)(586-1044 Δaa) sgo1Δ ,   bub1(1-826)(827-1044 Δaa) sgo1Δ
+ sister chromatid nondisjunction at meiosis II
bub1-KD(K762R,D900N aa) hta1-S121A(S122A aa) hta2-S121A(S122A aa) ,   hta1-S121A(S122A aa) hta2-S121A(S122A aa) ,   sgo1Δ sgo2Δ ,   cut7Δ pkl1Δ ,   sgo1-CD-fusion swi6Δ ,   sgo1-VE-CD((sgo1-VE)-swi6(69-215)) swi6Δ ,   psc3Δ/psc3Δ rec11+[Overexpression]/rec11+[Overexpression] rec8+[Overexpression]/rec8+[Overexpression]
+ sister kinetochore dissociation in meiotic metaphase I with equational sister chromatid segregation in meiosis I
bub1-KD(K762R,D900N aa) hta1-S121A(S122A aa) hta2-S121A(S122A aa) ,   bub1Δ nup132Δ ,   hhp1+[Knockdown] hhp2Δ sgo1Δ ,   hta1-S121A(S122A aa) hta2-S121A(S122A aa) ,   mad2Δ nup132Δ ,   mad2Δ nup132Δ sgo1Δ ,   mad2Δ sgo1Δ ,   moa1-101A(102-172 Δaa) rec12Δ ,   moa1Δ rec12Δ ,   nup132Δ sgo1Δ ,   plo1-TEVAA341(plo1(1-341)-(ENLYFQGAS)-plo1(342-405)-(ENLYFQGAS)-plo1(406-683)) rec12Δ ,   rec12Δ sgo1Δ ,   sgo1Δ sgo2Δ ,   mad2Δ rec12Δ ,   ark1+[Knockdown]/ark1+[Knockdown] rec12Δ/rec12Δ sgo1Δ/sgo1Δ ,   ark1+[Knockdown]/ark1+[Knockdown] sgo1Δ/sgo1Δ ,   bub1Δ/bub1Δ rec8Δ/rec8Δ ,   ctf8Δ/ctf8Δ rec12Δ/rec12Δ ,   dam1Δ/dam1Δ rec12Δ/rec12Δ sgo1Δ/sgo1Δ ,   dam1Δ/dam1Δ sgo1Δ/sgo1Δ ,   dcc1Δ/dcc1Δ rec12Δ/rec12Δ ,   mad2Δ/mad2Δ sgo1Δ/sgo1Δ ,   moa1Δ/moa1Δ plo1-CD(2 x Chromodomain fusion) ,   moa1Δ/moa1Δ plo1-cnp3C(cnp3C fusion) ,   moa1Δ/moa1Δ rec12Δ/rec12Δ ,   pds5Δ/pds5Δ rec12Δ/rec12Δ ,   psm3-3A(S110A,T182A,S1001A aa)/psm3-3A(S110A,T182A,S1001A aa) wpl1Δ/wpl1Δ ,   rec12Δ/rec12Δ rec8-2A15A(T113A,S131A,S148A,S160A,T169A,T175A,S176A,S180A,S186A,S187A,S193A,S197A,T198A,T216A,S225A,S449A,S450A aa)/rec8-2A15A(T113A,S131A,S148A,S160A,T169A,T175A,S176A,S180A,S186A,S187A,S193A,S197A,T198A,T216A,S225A,S449A,S450A aa) ,   rec12Δ/rec12Δ rec8Δ/rec8Δ ,   rec12Δ/rec12Δ sgo1Δ/sgo1Δ
+ sister kinetochore dissociation in meiotic metaphase I, normal chromosome segregation in meiosis I, and sister chromatid non-disjunction in meiosis II
ark1-as3(L166A,S229A,Q28R,Q176R aa) rec12Δ ,   cnp3C-TEV plo1-TEVAA341(plo1(1-341)-(ENLYFQGAS)-plo1(342-405)-(ENLYFQGAS)-plo1(406-683)) ,   mad2Δ rec12Δ ,   moa1Δ mph1Δ ,   moa1Δ mph1Δ spc7-12E(T77E,S221E,T257E,T338E,T366E,T395E,T413E,T422E,T453E,T507E,T529E,T552E aa) ,   moa1Δ plo1-cnp3C-TEV ,   sgo1-VE(V242E aa) spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa) ,   spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa) swi6Δ
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