Last updated: 2025-03-13 429297 annotations 4738 curated publications
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Ontology term: increased DNA damage (FYPO:0003546)
Definition Parents
A cell phenotype in which the amount of DNA damage measured in a cell is greater than normal. The number, extent, or both of damage sites may be increased.
External links: BioPortal
Single locus phenotype annotations for FYPO:0003546 and its descendants
Cell
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+ increased DNA damage at rDNA during G0
dcr1Δ
+ increased DNA damage at stalled replication fork
pfh1+[Knockdown]
+ increased DNA damage at tRNA genes
maf1Δ
+ increased DNA damage during mitotic S phase
mrc1Δ
+ increased DNA damage during vegetative growth
alp13Δ ,   clr6-1(G269D aa) ,   cnd2-1(A114T aa) ,   nap1Δ
+ increased number of DNA breakpoint junctions
tlh2+[Overexpression]
+ increased number of DNA breakpoint junctions during stationary phase
sir2Δ
+ increased number of double-strand break sites during meiotic cell cycle
ctp1Δ ,   hop1Δ
+ increased number of double-strand break sites during mitotic S phase
cdc21-M68(unknown) ,   mcm4-tstd(Ub-DHFRts-mcm4)
+ increased number of double-strand break sites during vegetative growth
hrq1-HD(D444A,E445A aa)[Overexpression] ,   mcb1+[Overexpression] ,   mcl1-102(269-815,L268LKPSLAMVIIVS) ,   mcl1Δ ,   pof3Δ ,   swi1Δ ,   tel2+[Knockdown] ,   asf1-33(A16T,L61P,E119K,L121P,N156S,E180G aa) ,   cdc17-K42(E298K aa) ,   cdc19-P1(P257L,T272I aa) ,   cdc22-M45(unknown) ,   cdc27-K3(G57R aa) ,   cdc6-23(E229K aa) ,   cds1Δ ,   mcm7-98(G1931A nt) ,   mis5-268(unknown) ,   rad3Δ ,   rad51Δ ,   rad52Δ
+ increased transcription-induced DNA damage
cut14+[Knockdown]
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