Last updated: 2025-03-13 429297 annotations 4738 curated publications
Contact curators ...
Ontology term: lagging chromosomes (FYPO:0002090)
Definition Parents
A cellular process phenotype in which homologous chromosomes or sister chromatids do not move towards the spindle poles at the same time during nuclear division, but instead one or more chromosomes remain distant from the spindle pole after the bulk of the DNA has separated. Segregation may stop before completing separation of chromosomes, or may eventually be completed.
External links: BioPortal
Single locus phenotype annotations for FYPO:0002090 and its descendants
Cell
Show details ...
Filters:
+ lagging chromosomes
ccp1+[Overexpression] ,   ccp1-4A(L10A,F17A,I24A,F32A aa)
+ abnormal chromosome segregation during meiosis I with premature sister kinetochore separation, lagging chromosomes, and normal chromosome separation
clr4-F449Y(aa)/clr4-F449Y(aa)
+ abnormal mitotic sister chromatid segregation with lagging chromosomes and decreased rate of mitotic spindle elongation
rad21-K1(unknown)
+ abnormal mitotic sister chromatid segregation with lagging chromosomes, complete sister chromatid separation, and decreased rate of mitotic spindle elongation
chp1Δ ,   csp10-439(unknown) ,   alp13Δ
+ lagging chromosomes during meiosis I
csm1Δ ,   sgo2Δ ,   klp6Δ ,   dbl2Δ/dbl2Δ
+ lagging chromosomes during meiosis II
csm1Δ ,   sgo1Δ ,   klp6Δ ,   dbl2Δ/dbl2Δ
+ lagging meiotic chromosomes
dus3Δ ,   mph1Δ ,   dli1Δ/dli1Δ
+ lagging mitotic chromosomes
alp7Δ(307-312)(aa) ,   ams2::ura4[Null] ,   asp1-D333A(aa) ,   bub1-KD(K762R,D900N aa) ,   bub1Δ ,   ccp1Δ ,   clr4-S5(unknown) ,   cnp3Δ ,   cos1-22(A574D aa) ,   csi1-I463N,P464N(aa) ,   csi1Δ ,   csi2Δ ,   ddb1Δ ,   dsh1Δ ,   epe1Δ ,   eso1-G799D(aa) ,   fta1-ts(unknown) ,   gtb1-93(P302L aa) ,   hrk1Δ ,   hsp104Δ ,   klp5-Q582P(aa) ,   mde4-12A(S147A,S242A,S247A,S252A,S270A,T275A,S290A,S295A,S316A,S349A,S354A,S401A aa) ,   mhf2Δ ,   mis4-242(G1326E aa) ,   mph1-ΔK(323-678 Δnt) ,   mph1Δ ,   mzt1-T27W(aa) ,   ndc80-NH12(F420S aa) ,   ned1-1(G402D aa) ,   nsk1-18A(S71A,S103A,S113A,S140A,S171A,S195A,S206A,S221A,S236A,T240A,T255A,S257A,S289A,S344A,S379A,S399A,T411A,T437A aa) ,   pds5Δ ,   pof3Δ ,   prp13-1(G35A nt) ,   psc3-1T(unknown) ,   psc3-407(T234I aa) ,   psf2Δ ,   rik1::LEU2(disruption)[Null] ,   rpb2-m203(N44Y aa) ,   scm3-106(L73F aa) ,   scm3-139(L56F aa) ,   scm3-15(S281L aa) ,   sgo2Δ ,   sim1-(unknown) ,   sim3-143(G81E aa) ,   sim3-205(E207K aa) ,   sim4-193(unknown) ,   stc1Δ ,   swi6::his1(disruption) ,   swi6Δ ,   top2-2A(S1363A,S1364A aa) ,   acr1-936(unknown) ,   ago1Δ ,   alm1Δ ,   ark1-T7(unknown) ,   bir1-46(C976T aa) ,   bub1Δ ,   bub3Δ ,   cbp1::ura4(disruption) ,   cid12-DADA(D77A,D79A aa) ,   cid12Δ ,   clr4Δ->clr4+(reintroduced clr4+) ,   clr6-1(G269D aa) ,   cnd2-3A(S5A,S41A,S52A aa) ,   cnp3-T28E(aa) ,   cos1-17(V233A aa) ,   cos1-22(A574D aa) ,   cos1-38(G622E aa) ,   cos1-7(G242R aa) ,   cos1-86(Q765*) ,   cul4-1(marker gene insertion at 3'-UTR) ,   cut17-275(A990T aa) ,   dbl2Δ ,   dcr1Δ ,   dis1-6A(T279A,S293A,S300A,S551A,S556A,S590A aa) ,   elf1Δ ,   hip1Δ ,   hip3Δ ,   hrp1Δ ,   hrp3Δ ,   mcl1-1(W109*) ,   mde4-12A(S147A,S242A,S247A,S252A,S270A,T275A,S290A,S295A,S316A,S349A,S354A,S401A aa) ,   mis4-367(G1487D aa) ,   mts4-1(unknown) ,   nrm1Δ ,   pob3Δ ,   prp16-2(Q140*) ,   pst1-1(W1305*) ,   rdp1-D903A(aa) ,   res2Δ ,   sal3Δ ,   slm9Δ ,   swi6-115(W269R aa) ,   swi6Δ ,   wip1Δ ,   yox1Δ ,   dis1Δ ,   swi6Δ ,   bub1Δ/bub1Δ
hhf1+[Overexpression] affecting cnp1
+ lagging mitotic chromosomes, with complete sister chromatid separation
bir1+[Knockdown] ,   bir1-1(T194A aa) ,   csm1Δ ,   klp5Δ ,   klp6Δ ,   mde4Δ ,   ask1Δ ,   dam1Δ ,   dcn1Δ ,   dhc1Δ ,   klp5Δ ,   klp6Δ ,   mad2Δ
+ meroterically attached lagging mitotic chromosomes
clr4Δ ,   csm1Δ ,   cdc13-117(C379Y aa) ,   cdc13-M7(E255G aa) ,   hrk1-pim(K8A,T9A,Y10A,G11A aa) ,   pds5-him(P84A,D85A,P87A aa) ,   rad21-K1(unknown) ,   bir1-8A(S202A,S229A,S244A,S278A,S294A,T393A,T831A,T908A aa)
Multi-locus phenotype annotations for FYPO:0002090 and its descendants
Cell
Show details ...
Filters:
+ abnormal chromosome segregation during meiosis I with premature sister kinetochore separation, lagging chromosomes, and normal chromosome separation
rec12Δ sgo1Δ
+ abnormal mitotic sister chromatid segregation with lagging chromosomes and decreased rate of mitotic spindle elongation
bub1Δ csp10-439(unknown) ,   bub1Δ csp10-439(unknown) dma1Δ
+ lagging chromosomes during meiosis I
moa1Δ/moa1Δ rec12Δ/rec12Δ
+ lagging mitotic chromosomes
bub1-KD(K762R,D900N aa) hta1-S121A(S122A aa) hta2-S121A(S122A aa) ,   bub1Δ mph1Δ ,   dam1-A8-ts(H126R,E149G aa) klp5Δ ,   dis1Δ klp5-Q582P(aa) ,   eso1-G799D(aa) pds5Δ ,   eso1-G799D(aa) spt2Δ ,   hta1-S121A(S122A aa) hta2-S121A(S122A aa) ,   alm1Δ ark1-T7(unknown) ,   bdf2Δ dcr1Δ ,   bir1-CD(bir1-CD-fusion) hht1-T3A(T4A aa) hht2-T3A(T4A aa) hht3-T3A(T4A aa) hta1-S121A(S122A aa) hta2-S121A(S122A aa) ,   cbh1Δ cbp1::ura4(disruption) ,   chp1-D48S,D51S(aa) clr4Δ->clr4+(reintroduced clr4+) ,   chp1-E23V(aa) clr4Δ->clr4+(reintroduced clr4+) ,   chp1-N59A(aa) clr4Δ->clr4+(reintroduced clr4+) ,   chp1-V24M(aa) clr4Δ->clr4+(reintroduced clr4+) ,   chp2Δ dfp1-3A(P448A,V450A,I452A aa) ,   chp2Δ dfp1-3A(P448A,V450A,I452A aa) swi6Δ ,   chp2Δ swi6Δ ,   clr6-1(G269D aa) pst1-1(W1305*) ,   dfp1-3A(P448A,V450A,I452A aa) swi6Δ ,   dfp1-CFP-2CD(dfp1-CFP-swi6(69-215)-swi6(69-215)) swi6Δ ,   hht1-T3A(T4A aa) hht2-T3A(T4A aa) hht3-T3A(T4A aa) ,   hht1-T3A(T4A aa) hht2-T3A(T4A aa) hht3-T3A(T4A aa) hta1-S121A(S122A aa) hta2-S121A(S122A aa) ,   hht1-T3A(T4A aa) hht2-T3A(T4A aa) hht3-T3A(T4A aa) sgo2Δ ,   hrk1Δ sgo2Δ ,   hrp1Δ hrp3Δ ,   hta1-R18A(R19A aa) hta2-R18A(R19A aa) pht1+[Knockdown] ,   hta1-S121A(S122A aa) hta2-S121A(S122A aa) ,   mis4-367(G1487D aa) pef1-as(F78A aa) ,   mis4-367(G1487D aa) pef1Δ ,   mis4-I803M(aa) pph3Δ psm3-K105N,K106N(aa) ,   nda3-KM311(G93E aa) pds5Δ ,   pph3Δ psm3-K105N,K106N(aa) ,   ras1Δ tea1Δ ,   alp14Δ mal2-1(E277K aa) ,   eso1-G799D(aa) sor1Δ
+ lagging mitotic chromosomes, with complete sister chromatid separation
klp5Δ klp6Δ ,   ase1Δ klp5Δ ,   dcn1Δ mad2Δ
+ meroterically attached lagging mitotic chromosomes
bir1-8D(S202D,S229D,S244D,S278D,S294D,T393D,T831D,T908D aa) cdc13-M7(E255G aa) ,   hrk1-KD-CD(hrk1-K184R-CD) pds5-him(P84A,D85A,P87A aa)
Mastodon